Original Article
A Randomized Trial of Tai Chi for Fibromyalgia
N Engl J Med 2010; 363:743-754August 19, 2010
- Abstract
Background
Previous research has suggested that tai chi offers a therapeutic benefit in patients with fibromyalgia.
Methods
We conducted a single-blind, randomized trial of classic Yang-style tai chi as compared with a control intervention consisting of wellness education and stretching for the treatment of fibromyalgia (defined by American College of Rheumatology 1990 criteria). Sessions lasted 60 minutes each and took place twice a week for 12 weeks for each of the study groups. The primary end point was a change in the Fibromyalgia Impact Questionnaire (FIQ) score (ranging from 0 to 100, with higher scores indicating more severe symptoms) at the end of 12 weeks. Secondary end points included summary scores on the physical and mental components of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). All assessments were repeated at 24 weeks to test the durability of the response.
Results
Of the 66 randomly assigned patients, the 33 in the tai chi group had clinically important improvements in the FIQ total score and quality of life. Mean (±SD) baseline and 12-week FIQ scores for the tai chi group were 62.9±15.5 and 35.1±18.8, respectively, versus 68.0±11 and 58.6±17.6, respectively, for the control group (change from baseline in the tai chi group vs. change from baseline in the control group, −18.4 points; P<0.001). The corresponding SF-36 physical-component scores were 28.5±8.4 and 37.0±10.5 for the tai chi group versus 28.0±7.8 and 29.4±7.4 for the control group (between-group difference, 7.1 points; P=0.001), and the mental-component scores were 42.6±12.2 and 50.3±10.2 for the tai chi group versus 37.8±10.5 and 39.4±11.9 for the control group (between-group difference, 6.1 points; P=0.03). Improvements were maintained at 24 weeks (between-group difference in the FIQ score, −18.3 points; P<0.001). No adverse events were observed.
Conclusions
Tai chi may be a useful treatment for fibromyalgia and merits long-term study in larger study populations. (Funded by the National Center for Complementary and Alternative Medicine and others; ClinicalTrials.gov number, NCT00515008.)
Media in This Article
Figure 1
Screening, Randomization, and Completion of 12-Week and 24-Week Evaluations.Figure 2
Mean Changes in Nine Secondary Outcomes at 12 and 24 Weeks, According to Treatment Group.Article Activity
- Article
Fibromyalgia is a common and complex clinical syndrome characterized by chronic and widespread musculoskeletal pain, fatigue, sleep disturbance, and physical and psychological impairment.1,2 Evidence-based guidelines suggest that fibromyalgia is typically managed with multidisciplinary therapies involving medication, cognitive behavioral therapy, education, and exercise.3-5
Although exercise is beneficial for fibromyalgia and has been advocated as a core component of its treatment,6-8 most patients continue to be in considerable pain years after the original diagnosis and require medication to control symptoms; they also remain aerobically unfit, with poor muscle strength and limited flexibility.9 New approaches are needed to reduce musculoskeletal pain in patients with fibromyalgia and to improve their physical and emotional functioning and quality of life.
Tai chi is a mind–body practice that originated in China as a martial art. It combines meditation with slow, gentle, graceful movements, as well as deep breathing and relaxation, to move vital energy (or qi) throughout the body. It is considered a complex, multicomponent intervention that integrates physical, psychosocial, emotional, spiritual, and behavioral elements.10 Because of its mind–body attributes, tai chi could be especially well suited to the treatment of fibromyalgia. In fact, tai chi is practiced preferentially in the United States by persons with musculoskeletal and mental health conditions.11,12 A small, nonrandomized study showed that tai chi reduced symptoms and improved quality of life in patients with fibromyalgia,13 and it has also been shown to have potential therapeutic benefits in patients with other chronic rheumatic conditions, such as rheumatoid arthritis and osteoarthritis.14,15
We conducted a single-blind, randomized, controlled trial to compare the physical and psychological benefits of tai chi with those of a control intervention that consisted of wellness education and stretching. We hypothesized that at the end of the 12-week intervention period, patients in the tai chi group would have a greater reduction in musculoskeletal pain and greater improvements in sleep quality, physical and psychological function, and health-related quality-of-life scores than those in the control group.
Methods
Study Participants
We conducted the trial from July 2007 through May 2009 at Tufts Medical Center, a tertiary care academic hospital in Boston. The institutional review board of the Tufts University Health Sciences Campus approved the study protocol. Eligible patients were 21 years of age or older and fulfilled the American College of Rheumatology 1990 diagnostic criteria for fibromyalgia. These criteria include a history of widespread musculoskeletal pain on the right and left sides of the body as well as above and below the waist, with a minimum duration of 3 months, and tenderness on pressure at 11 or more of 18 specific sites (tender points), with moderate or more severe tenderness reported on digital palpation.16 We excluded persons who had participated in tai chi training within the past 6 months; those with serious medical conditions that might limit their participation; those with other diagnosed medical conditions known to contribute to fibromyalgia symptoms, such as thyroid disease, inflammatory arthritis, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, myositis, vasculitis, or Sjögren's syndrome; women who had a positive pregnancy test or who were planning to become pregnant during the study period; and persons who were unable to pass the Mini–Mental State Examination (i.e., those with a score less than or equal to 24 [out of 30] points).17 Participants were allowed to continue routine medications and maintain usual visits with their primary care physicians or rheumatologists throughout the study. All patients provided written informed consent.
Study Design
We assigned participants to tai chi or the control intervention in three randomization cycles, using computer-generated numbers. The randomized treatment assignments were sealed in opaque envelopes and were opened individually for each patient who agreed to be in the study.
The sponsors had no role in the design and conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. The study was conducted in accordance with the trial protocol.
Tai Chi Intervention
The tai chi intervention took place twice a week for 12 weeks, and each session lasted for 60 minutes. Classes were taught by a tai chi master with more than 20 years of teaching experience. In the first session, he explained the theory behind tai chi and its procedures and provided participants with printed materials on its principles and techniques. In subsequent sessions, participants practiced 10 forms from the classic Yang style of tai chi18 under his instruction. Each session included a warm-up and self-massage, followed by a review of principles, movements, breathing techniques, and relaxation in tai chi. Throughout the intervention period, participants were instructed to practice tai chi at home for at least 20 minutes each day. At the end of the 12-week intervention, participants were encouraged to maintain their tai chi practice, using an instructional DVD, up until the follow-up visit at 24 weeks.
Control Intervention
Our wellness education and stretching program similarly included 60-minute sessions held twice a week for 12 weeks.19 At each session, a variety of health professionals provided a 40-minute didactic lesson on a topic relating to fibromyalgia, including the diagnostic criteria; coping strategies and problem-solving techniques; diet and nutrition; sleep disorders and fibromyalgia; pain management, therapies, and medications; physical and mental health; exercise; and wellness and lifestyle management.20 For the final 20 minutes of each class, participants practiced stretching exercises supervised by the research staff. Stretches involved the upper body, trunk, and lower body and were held for 15 to 20 seconds. Participants were instructed to practice stretching at home for 20 minutes a day.
Adherence to Programs
Participants in both groups were encouraged to continue their routine activities during the 12-week intervention period but were asked not to take part in any new, additional exercise programs. Adherence was maximized by an oral and written commitment from all participants at the baseline evaluation. The research staff asked participants who missed a class to attend a make-up class. Throughout the 12-week intervention period, we tracked the number of missed sessions and asked subjects to complete daily logs indicating the amount of time they practiced tai chi or stretching exercises.
Outcome Measures and Follow-up
The primary outcome measure was the change in the Fibromyalgia Impact Questionnaire (FIQ) score from baseline to the end of the 12-week intervention. The FIQ is a well-validated, multidimensional measure of the overall severity of fibromyalgia as rated by patients. Categories include the intensity of pain, physical functioning, fatigue, morning tiredness, stiffness, depression, anxiety, job difficulty, and overall well-being.21 The total score ranges from 0 to 100, with higher scores indicating more severe symptoms.
Secondary outcomes during the 12-week intervention included FIQ scores (obtained weekly). Global pain status was assessed separately by the participant and the study physician, who was unaware of the group assignment, with the use of a visual-analogue scale (VAS) (range, 0 to 10, with higher scores indicating greater pain). The study physician also determined the number of tender sites (of 18 sites in total) according to the standardized protocol.16,22 The research staff, who were also unaware of the group assignments, evaluated participants' physical performance by measuring the time to completion of the 6-minute walk test (measured in yards).23 Additional measures included the score on the Pittsburgh Sleep Quality Index (PSQI) (range, 0 to 21, with higher scores indicating worse sleep quality),24 the score on the depression scale of the Center for Epidemiologic Studies (CES-D) (range, 0 to 60, with higher scores indicating more severe depression),25 the score on the Outcome Expectations for Exercise Scale (range, 1 to 5, with 1 indicating no expectations for exercise and 5 the highest expectations for exercise),26 the score on the Chronic Pain Self-Efficacy Scale (CPSS) (range, 1 to 10, with higher scores indicating greater self-efficacy with respect to the management of chronic pain),27 and the summary scores for the physical and mental quality-of-life components of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) (range, 0 to 100, with higher scores indicating better health status).28
Participants continued to take their regular medications, and we recorded any changes in the use of analgesics, antidepressants, anticonvulsants, muscle relaxants, benzodiazepines, dopamine agonists, or 5-hydroxytryptamine agonists. To test durability of the response, outcome measurements were repeated at the 24-week follow-up visit.
Throughout the entire intervention period, we monitored adverse events, using a standard adverse-event case report form at each visit. This form included a description of all unanticipated benefits and undesirable experiences, particularly falls and exacerbations of fibromyalgia symptoms. Lack of an effect with tai chi or with stretching and wellness education was not considered an adverse event. By the nature of an exercise program, delayed muscle soreness (mild muscle pain or discomfort that occurred after exercise, did not require medical intervention, and resolved within 72 hours) was an expected outcome and thus was not considered an adverse event.
Statistical Analysis
A trial conducted in Sweden, in which 58 participants were assigned to 32 weeks of either aquatic exercise or education (control), showed a significant effect size (i.e., standardized mean difference between groups) of 0.7 points in the FIQ score (mean [±SD] change, –0.9±1.3 in the exercise group vs. 0.0±1.4 in the control group).29 Guided by these results, we randomly assigned 66 patients to two groups (33 patients to each), which provided 78% power to detect a difference between means at a significance level of 5% with the use of a two-sided t-test.
We compared between-group changes in outcomes at 0, 12, and 24 weeks (and weekly FIQ scores during the 12-week intervention) with mixed models, using time and group as categorical fixed factors, interactions between time and group, random intercepts, and an unstructured covariance matrix. Effects were evaluated on an intention-to-treat basis, and participants who did not complete the follow-up period were considered not to have had any changes in scores. We tested for potential interactions between treatment and covariates, including age, sex, body-mass index, fibromyalgia duration, pain-severity score, coexisting illnesses, health status, and medication use. A two-sided P value of less than 0.05 indicated statistical significance. Results are presented as between-group differences with 95% confidence intervals.
Results
Between July 2007 and December 2008, we screened 356 patients by telephone. Of the 124 patients who resided near Boston, 90 qualified for the baseline evaluation; 24 patients in this group were excluded for various reasons, and the 66 eligible participants were randomly assigned in equal numbers to either the tai chi intervention or the control intervention (Figure 1Figure 1
Screening, Randomization, and Completion of 12-Week and 24-Week Evaluations.).Baseline Characteristics of the Patients
Table 1Table 1
Baseline Characteristics of the Study Participants. shows baseline data for the 66 participants before randomization. Participants had a mean age of 50 years, 86% were women, and 56% were white; the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 32.7. On average, participants had had fibromyalgia for 11 years. Baseline characteristics were reasonably well balanced between the two groups, except that the tai chi group had a lower CES-D score. The average score on the physical component of the SF-36 was about 2 SD below normal, indicating a cohort with poor health.The rate of attendance during the 12-week intervention was 77% for the tai chi group and 70% for the control group. Five patients withdrew from the study by 12 weeks, and seven by 24 weeks (Figure 1).
Table 2Table 2
Changes in Primary and Secondary Outcomes. and Figure 2Figure 2Mean Changes in Nine Secondary Outcomes at 12 and 24 Weeks, According to Treatment Group. show changes from baseline to 12 and 24 weeks in the two groups for all outcomes.At 12 weeks, the tai chi group had a significantly greater decrease in the total FIQ score than did the control group (−27.8 points [95% confidence interval {CI}, −33.8 to −21.8] vs. −9.4 points [95% CI, −15.5 to −3.4]). The mean between-group difference was −18.4 points (95% CI, −26.9 to −9.8). Figure 3Figure 3
Fibromyalgia Impact Questionnaire (FIQ) Scores during the 12-Week Intervention Period, According to Treatment Group. shows that the mean between-group difference in FIQ scores gradually increased during the intervention. Similarly, at 24 weeks the tai chi group had a significant reduction in symptoms (change in the total FIQ score from baseline to 24 weeks, −28.6 points [95% CI, −34.8 to −22.4]), which was greater than the improvement in the control group; the mean between-group difference in the change from baseline to 24 weeks was −18.3 points (95% CI, −27.1 to −9.6; P<0.001).At 12 weeks, the tai chi group had greater mean improvement in sleep quality than the control group, as measured by the change in the PSQI score (mean between-group difference, −2.9 points [95% CI, −4.6 to −1.2]; P=0.001). In addition, the tai chi group had greater improvement as measured by the change in the patient's global assessment (mean between-group difference, −1.9 points [95% CI, −3.1 to −0.7]; P=0.002). The change from baseline to 12 weeks in the physician's objective global assessment also differed significantly between the two groups (mean between-group difference, −1.1 points [95% CI, −1.9 to −0.2]; P=0.02). The 6-minute walk test was significantly better with tai chi at 12 weeks (mean between-group difference, 44.4 yd [95% CI, 12.3 to 76.4]; P=0.007). At 12 weeks, the tai chi group also had greater improvement in the scores for the SF-36 physical component (mean between-group difference, 7.1 points [95% CI, 3.1 to 11.1]; P=0.001), the SF-36 mental component (mean between-group difference, 6.1 points [95% CI, 0.7 to 11.6]; P=0.03), and the CES-D (mean between-group difference, −5.9 points [95% CI, −9.8 to −1.9]; P=0.005). The tai chi group had greater improvement in the CPSS score, but the difference was not significant (mean between-group difference, 1.0 point [95% CI, −0.03 to 2.0]; P=0.06). The body-mass index remained stable in both groups.
Improvements with tai chi were maintained at 24 weeks for sleep quality, the patient's and physician's global assessments, the scores for the SF-36 physical and mental components, and the CES-D score. The changes from baseline to 24 weeks in the 6-minute walk test and the CPSS score also favored tai chi over the control intervention, but the between-group difference was not significant.
Table 3Table 3
Patients with Clinically Meaningful Improvement. shows that, with a clinically meaningful change in the FIQ score defined as 8.1 points,30 significantly more patients in the tai chi group than in the control group had improvement: 79% versus 39% (P=0.001) at 12 weeks, and 82% versus 53% (P=0.009) at 24 weeks. The tai chi group also met standards for clinically meaningful improvement in the patient's VAS score for pain and in sleep-quality, CES-D, and SF-36 scores significantly more often than did controls (Table 3).All treatment effects remained significant after adjusting for the baseline CES-D score, and no interactions with treatment were found. No adverse events were noted during the study interventions.
Medication Use
At 12 weeks, more subjects had discontinued medication used to treat fibromyalgia in the tai chi group than in the control group, but the difference was not significant (11 of 31 patients vs. 4 of 26, P=0.09).
Discussion
This randomized, controlled trial shows that tai chi is potentially a useful therapy for patients with fibromyalgia. The effect was evident in the FIQ score, a well-validated, multidimensional instrument for the assessment of fibromyalgia, and in other measures of pain and quality of life and was consistent with both subjective and objective assessments. The observed benefits exceeded the specified thresholds for clinically significant improvement in the FIQ score30 and in the measures used to assess pain,31 sleep quality,24 depression,32 and quality of life,28,33 and these benefits were sustained at 24 weeks. No adverse events were reported in the study participants, indicating that tai chi is probably a safe therapy for patients with fibromyalgia.
Our results are consistent with those of a previous, nonrandomized trial of tai chi for fibromyalgia, as well as with the findings in other studies showing the benefits of tai chi with regard to musculoskeletal pain, depression, and quality of life.13,34 Our findings are also consistent with observations from other clinical trials and meta-analyses that support the benefits of physical exercise and mind–body practice for symptom management in fibromyalgia.35-41
The biologic mechanisms by which tai chi might affect the clinical course of fibromyalgia remain unknown. As a complex, multicomponent intervention, tai chi may act through many intermediate variables along the pathway to improved health outcomes. Physical exercise has been shown to increase muscle strength and blood lactate levels in some patients with fibromyalgia.42 Mind–body interventions may improve psychosocial well-being, increase confidence, and help patients overcome fear of pain.43 Furthermore, controlled breathing and movements promote a restful state and mental tranquility, which may raise pain thresholds and help break the “pain cycle.”44 All these components may influence neuroendocrine and immune function as well as neurochemical and analgesic pathways that lead to enhanced physical, psychological, and psychosocial well-being and overall quality of life in patients with fibromyalgia.40,45,46
Our study had some limitations. We did not use a double-blind study design, since this would have required the use of sham tai chi, for which no validated approach currently exists. Devising a sham mind–body intervention poses a set of unique challenges when one attempts to separate the various mind and body components. Nevertheless, the development of some form of sham intervention for use in future studies of tai chi is a desirable goal. To minimize the influence of preexisting beliefs and expectations with respect to tai chi (e.g., its possible placebo effect), we informed participants only that the study was designed to test the effects of two different types of exercise training programs, one of which was combined with education. Deemphasizing tai chi may have lessened participants' expectations and minimized biases. Notably, the baseline outcome expectations of benefit from an exercise intervention were similar in the tai chi and control groups (3.7±0.8 and 3.9±0.7, respectively), indicating that our neutral presentation of the interventions may have been successful.
The fact that treatment was delivered by a single tai chi master at a single center also potentially limits the generalizability of our results. However, the group of patients with poor health status at baseline may in general resemble patients with fibromyalgia. For these reasons, it would be prudent to further explore the benefits of tai chi for fibromyalgia in other settings with other instructors. Since tai chi is a complex mind–body intervention with a variety of active ingredients, such as social support, relaxation, and cognitive behavioral elements,47 assessment of its placebo effect might require separate evaluations of these ingredients. Finally, we followed participants for only 24 weeks, so the long-term effectiveness of tai chi in patients with fibromyalgia remains to be determined.
In conclusion, our preliminary findings indicate that tai chi may be a useful treatment in the multidisciplinary management of fibromyalgia. Longer-term studies involving larger clinical samples are warranted to assess the generalizability of our findings and to deepen our understanding of this promising therapeutic approach.
The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Complementary and Alternative Medicine or the National Institutes of Health.
Supported by a grant (R21AT003621) from the National Center for Complementary and Alternative Medicine of the National Institutes of Health, the American College of Rheumatology Research and Education Foundation Health Professional Investigator Award, and the Boston Claude D. Pepper Older Americans Independence Center Research Career Development Award.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
We thank the data and safety monitoring board members, Drs. Daniel S. Rooks, Karen H. Costenbader, and Lee-Jen Wei, for their insightful suggestions concerning the study protocol; Marcie Griffith, Judith L. Ramel, Melynn Nuite, Xiaogang Gao, and Drs. Irwin Rosenberg, John Griffith, Ronenn Roubenoff, Raveendhara Bannuru, Aghogho Okparavero, and Paola DePablo; the Clinical Research Center nurses for their help with various aspects of the study and Drs. Haewook Han and Harry Pino for their expertise in teaching the control group; and the study participants, whose cooperation, encouragement, and enthusiasm were an inspiration to us.
Source Information
From the Division of Rheumatology (C.W., R.K., J.Y., T.M.) and the Institute for Clinical Research and Health Policy Studies (C.H.S., Y.L.), Tufts Medical Center, Tufts University School of Medicine; and Mind–Body Therapies (R.R.) — both in Boston; and Newton–Wellesley Hospital, Newton, MA (D.L.G.).
Address reprint requests to Dr. Wang at the Division of Rheumatology, Tufts Medical Center, 800 Washington St., Box 406, Tufts University School of Medicine, Boston, MA 02111, or at cwang2@tuftsmedicalcenter.org.
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- Citing Articles (21)
Citing Articles
1
Stephanie A. Reid-Arndt, Sandy Matsuda, Cathy R. Cox. (2012) Tai Chi effects on neuropsychological, emotional, and physical functioning following cancer treatment: A pilot study. Complementary Therapies in Clinical Practice 18:1, 26-30
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Marko Nedeljkovic, Brigitte Ausfeld-Hafter, Konrad Streitberger, Roland Seiler, Petra H. Wirtz. (2012) Taiji practice attenuates psychobiological stress reactivity – A randomized controlled trial in healthy subjects. Psychoneuroendocrinology
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Elizabeth M. Tait, Sarah B. Laditka, James N. Laditka, Mary A. Nies, Elizabeth F. Racine. (2012) Use of Complementary and Alternative Medicine For Physical Performance, Energy, Immune Function, and General Health Among Older Women and Men in the United States. Journal of Women & Aging 24:1, 23-43
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Don L. Goldenberg, Daniel J. Clauw, Mary-Ann Fitzcharles. (2011) New Concepts in Pain Research and Pain Management of the Rheumatic Diseases. Seminars in Arthritis and Rheumatism 41:3, 319-334
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Angela J. Busch, Sandra C. Webber, Mary Brachaniec, Julia Bidonde, Vanina Dal Bello-Haas, Adrienne D. Danyliw, Tom J. Overend, Rachel S. Richards, Anuradha Sawant, Candice L. Schachter. (2011) Exercise Therapy for Fibromyalgia. Current Pain and Headache Reports 15:5, 358-367
CrossRef6
Suely Roizenblatt, Nilton Salles Rosa Neto, Sergio Tufik. (2011) Sleep Disorders and Fibromyalgia. Current Pain and Headache Reports 15:5, 347-357
CrossRef7
Catherine M Fetherston, Li Wei. (2011) The benefits of tai chi as a self management strategy to improve health in people with chronic conditions. Journal of Nursing and Healthcare of Chronic Illness 3:3, 155-164
CrossRef8
Lauren Terhorst, Michael J. Schneider, Kevin H. Kim, Lee M. Goozdich, Carol S. Stilley. (2011) Complementary and Alternative Medicine in the Treatment of Pain in Fibromyalgia: A Systematic Review of Randomized Controlled Trials. Journal of Manipulative and Physiological Therapeutics 34:7, 483-496
CrossRef9
J. Cabane. (2011) Qu’est-ce qui se cache derrière la fibromyalgie ?. La Revue de Médecine Interne 32:8, 455-460
CrossRef10
Kate Louise Franklyn, Emma Kathryn Guymer, Geoffrey Owen Littlejohn. (2011) Targeting fibromyalgia pain: brain–spinal cord and peripheral contributions. International Journal of Clinical Rheumatology 6:4, 463-474
CrossRef11
Tobias Schmidt-Wilcke, Daniel J. Clauw. (2011) Fibromyalgia: from pathophysiology to therapy. Nature Reviews Rheumatology 7:9, 518-527
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Emma S. Sjöquist, Nina Brodin, Jon Lampa, Irene Jensen, Christina H. Opava, . (2011) Physical Activity Coaching of Patients with Rheumatoid Arthritis in Everyday Practice: A Long-term Follow-up. Musculoskeletal Care 9:2, 75-85
CrossRef13
Afton L. Hassett, David A. Williams. (2011) Non-pharmacological treatment of chronic widespread musculoskeletal pain. Best Practice & Research Clinical Rheumatology 25:2, 299-309
CrossRef14
Hsiang-Yang Chen, Chao-Hua Chuang. (2011) The learning effectiveness of nursing students using online testing as an assistant tool: A cluster randomized controlled trial. Nurse Education Today
CrossRef15
Ana Carbonell-Baeza, Alejandro Romero, Virginia A. Aparicio, Pablo Tercedor, Manuel Delgado-Fernández, Jonatan R. Ruiz. (2011) T'ai-Chi Intervention in Men with Fibromyalgia: A Multiple-Patient Case Report. The Journal of Alternative and Complementary Medicine 17:3, 187-189
CrossRef16
Chenchen Wang. (2011) Tai Chi and Rheumatic Diseases. Rheumatic Disease Clinics of North America 37:1, 19-32
CrossRef17
Nadya M. Dhanani, Thomas J. Caruso, Adam J. Carinci. (2011) Complementary and Alternative Medicine for Pain: An Evidence-based Review. Current Pain and Headache Reports 15:1, 39-46
CrossRef18
Gustav Dobos, Iven Tao. (2011) The model of western integrative medicine: The role of Chinese medicine. Chinese Journal of Integrative Medicine 17:1, 11-20
CrossRef19
Kim D Jones, Laurie A King, Scott D Mist, Robert M Bennett, Fay B Horak. (2011) Postural control deficits in people with fibromyalgia: a pilot study. Arthritis Research & Therapy 13:4, R127
CrossRef20
(2010) A Randomized Trial of Tai Chi for Fibromyalgia. New England Journal of Medicine 363:23, 2265-2267
Full Text21
Yeh, Gloria Y., Kaptchuk, Ted J.Shmerling, Robert H., . (2010) Prescribing Tai Chi for Fibromyalgia — Are We There Yet?. New England Journal of Medicine 363:8, 783-784
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