Original Article
Pallidal Deep-Brain Stimulation in Primary Generalized or Segmental Dystonia
N Engl J Med 2006; 355:1978-1990November 9, 2006
- Abstract
Background
Neurostimulation of the internal globus pallidus has been shown to be effective in reducing symptoms of primary dystonia. We compared this surgical treatment with sham stimulation in a randomized, controlled clinical trial.
Methods
Forty patients with primary segmental or generalized dystonia received an implanted device for deep-brain stimulation and were randomly assigned to receive either neurostimulation or sham stimulation for 3 months. The primary end point was the change from baseline to 3 months in the severity of symptoms, according to the movement subscore on the Burke–Fahn–Marsden Dystonia Rating Scale (range, 0 to 120, with higher scores indicating greater impairment). Two investigators who were unaware of treatment status assessed the severity of dystonia by reviewing videotaped sessions. Subsequently, all patients received open-label neurostimulation; blinded assessment was repeated after 6 months of active treatment.
Results
Three months after randomization, the change from baseline in the mean (±SD) movement score was significantly greater in the neurostimulation group (−15.8±14.1 points) than in the sham-stimulation group (−1.4±3.8 points, P<0.001). During the open-label extension period, this improvement was sustained among patients originally assigned to the neurostimulation group, and patients in the sham-stimulation group had a similar benefit when they switched to active treatment. The combined analysis of the entire cohort after 6 months of neurostimulation revealed substantial improvement in all movement symptoms (except speech and swallowing), the level of disability, and quality of life, as compared with baseline scores. A total of 22 adverse events occurred in 19 patients, including 4 infections at the stimulator site and 1 lead dislodgment. The most frequent adverse event was dysarthria.
Conclusions
Bilateral pallidal neurostimulation for 3 months was more effective than sham stimulation in patients with primary generalized or segmental dystonia. (ClinicalTrials.gov number, NCT00142259.)
Media in This Article
Video
Four Patients with Dystonia.
Figure 1
Enrollment of Patients and Treatment Assignments.Article Activity
- Article
Video
Four Patients with Dystonia.
Primary dystonia comprises a group of idiopathic, incurable movement disorders that vary with respect to age at onset, body distribution, and genetic association.1 All these disorders are characterized by twisting, repetitive movements or abnormal postures caused by involuntary muscle contractions.2 The mainstay of treatment for focal or segmental dystonia is the injection of botulinum toxin to denervate the affected muscles.3 When this approach fails (because too many muscles are involved, the movement pattern is too complex, or neutralizing antibodies develop4), the management of dystonia becomes difficult. Drug therapy is often unsatisfactory,5 which leaves many patients with a profound incapacity of movement and the related stigma. Therefore, surgical approaches that have a favorable risk–benefit ratio, such as deep-brain stimulation,6 deserve investigation.
Reports on case series have described the highly successful use of continuous, high-frequency neurostimulation of the internal globus pallidus in severely disabled children7,8 and adults8-16 with primary generalized dystonia. There have been isolated case reports and small, uncontrolled cohort studies of the effect of this treatment on focal or segmental dystonia.17-24 Recently, the French multicenter Stimulation du Pallidum Interne dans la Dystonie (SPIDY) study10 reported prospective data with blinded assessments but did not include a control group.25 Sham-controlled trials are of particular importance, given the well-known placebo effect in pharmacologic trials involving dystonia.26 The placebo effect could be even greater with invasive therapies and could augment a possible rating bias by the treating physician. We report on the clinical efficacy and safety of bilateral pallidal deep-brain stimulation (delivered by means of permanently implanted brain electrodes connected through an extension to a fully implanted neurostimulator) for severe primary dystonia in a series of 40 patients who participated in a prospective trial of neurostimulation.
Methods
Study Design
We designed the study as a 3-month randomized, double-blind, sham-controlled trial, followed by either 3 or 6 months of open-label treatment, for a total of 6 months of neurostimulation in each group. During the study, we evaluated whether bilateral pallidal neurostimulation was effective in reducing symptoms of severe primary dystonia. The study was conducted at 10 academic centers in Germany, Norway, and Austria in collaboration with the Institute for Medical Informatics and Statistics at the University of Rostock, in Rostock, Germany. Data monitoring and management were performed by the Clinical Coordination Center in Marburg, Germany. A writing committee consisting of seven coauthors was responsible for analyzing and interpreting the data and writing the manuscript. The authors vouch for the completeness and veracity of the data and data analyses. The study sponsors were not involved in the design or execution of the trial, data analysis, or reporting of the trial results. The ethics committee of each participating center approved the study protocol, and all patients or their guardians provided written informed consent.
Eligibility
Eligible patients were between the ages of 14 and 75 years and had marked disability owing to primary generalized or segmental dystonia, despite optimal pharmacologic treatment, with a disease duration of at least 5 years. Exclusion criteria were previous brain surgery; cognitive impairment (<120 points on the Mattis Dementia Rating Scale, ranging from 0 to 144, with higher scores indicating higher functioning); moderate-to-severe depression (>25 points on the Beck Depression Inventory, ranging from 0 to 63, with higher scores indicating more severe depression); marked brain atrophy, as detected by magnetic resonance imaging (MRI) or computed tomography (CT); or other medical or psychiatric coexisting disorders that could increase the surgical risk or interfere with completion of the trial.
Baseline Measurements
Patients were videotaped with the use of a standardized protocol at baseline (within 6 weeks before surgery). Baseline measurements included ratings of movement and disability (as assessed by the Burke–Fahn–Marsden Dystonia Rating Scale,27 with scores ranging from 0 to 120 and 0 to 30, respectively, and higher scores indicating greater impairment). Quality of life was assessed with the Medical Outcomes Study 36-item Short-Form General Health Survey (SF-36), which evaluates both physical and mental components of functioning on a scale of 0 to 100, with higher scores indicating a higher level of function.28 The severity of dystonia and pain was assessed with the use of a visual analogue scale of pain and dystonia severity, with scores ranging from 0 to 10 and higher scores indicating greater severity. Measurements of walking (the duration and number of steps taken in a 14-m walk with one turn) and finger tapping (the number of taps in 30 seconds) were also performed. Cognitive and mental status were assessed with the Mattis Dementia Rating Scale (with scores ranging from 0 to 144 and lower scores indicating more severe dementia),29 the Brief Psychiatric Rating Scale30 (with scores ranging from 24 to 168 and higher scores indicating greater severity), the Beck Depression Inventory (with scores ranging from 0 to 63 and higher scores indicating more severe depression), and the Beck Anxiety Inventory31 (with scores ranging from 0 to 63 and higher scores indicating more severe anxiety).
Surgical Procedure
Permanent quadripolar electrodes (Medtronic model 3387 or 3389) were implanted bilaterally in the posteroventrolateral portion of the internal globus pallidus during one session, while the patient was under general anesthesia. The initial implantation target was 2 mm anterior to, 20 to 21 mm lateral to, and 2 to 6 mm below the midcommissural point; the localization of the site was further refined by a combination of direct visualization on MRI, microelectrode recordings, and intraoperative stimulation (depending on local resources). The electrodes were connected to a fully implanted neurostimulator (Kinetra, Medtronic) during the same or a subsequent surgical session. Postoperative MRI was performed in 24 patients to exclude asymptomatic hemorrhage and confirm adequate localization of electrodes at the ventral border of the posterolateral internal globus pallidus. In the remaining patients, target confirmation was obtained by postoperative stereotactic radiography or fusion of CT and MRI scans.
Randomization and Treatment
After surgery, patients were randomly assigned in a 1:1 ratio without stratification to receive either neurostimulation or sham stimulation with the use of a central randomization list. The numbers of patients in the two groups were balanced with the use of permuted blocks of four.
Within 1 week after surgery, a programming session was performed, during which the acute effects of increasing amplitudes of high-frequency neurostimulation were tested for each electrode contact (a trial of at least 30 seconds) in monopolar mode (frequency, 130 Hz; pulse width, 120 μsec). The contact for prolonged stimulation was selected on the basis of a reduction of dystonic hyperkinesia or the induction of phosphenes at a low threshold (suggesting proximity to the optic tract) or on the basis of neuroimaging studies (suggesting an electrode location at the ventral border of the pallidum in patients without acute stimulation effects). According to the group assignment, patients were either programmed to receive neurostimulation, with an amplitude of 0.5 V below the threshold of inducing acute adverse effects, or sham stimulation, with an amplitude of 0 V. Adjustments to measures of stimulation were not allowed during the first 3 months of the study unless intolerable adverse effects occurred. However, adjustments were performed at any time thereafter to maximize the clinical benefit or reduce adverse effects. Investigators adjusted doses of medication throughout the entire study as needed.
Patients were unaware of their group assignment until they had been reassessed at 3 months. Then the assignments were revealed, and neurostimulation was also initiated in the sham-stimulation group.
Serial Monitoring and Outcome Measures
Patients were reassessed with the use of baseline instruments 3 months after randomization and after 6 months of active neurostimulation (i.e., 6 months after randomization in the neurostimulation group and 9 months after randomization in the sham-stimulation group). Two independent experts on dystonia, who were unaware of the group assignments and order of the examinations, rated the severity of dystonia while watching videos of the patients, with the use of the movement score on the Burke–Fahn–Marsden Dystonia Rating Scale.27
Safety was assessed according to the frequency and severity of spontaneously reported adverse events. Both new symptoms and a worsening of preexisting symptoms were classified as adverse events. Serious adverse events were defined as death, life-threatening illness, hospital admission or prolonged hospitalization, persistent disability, and an event requiring intervention to avoid any of these outcomes.
Statistical Analysis
The primary null hypothesis was an outcome of no significant difference in the change in the movement score (an average of the two scores recorded by observers who were unaware of the group assignments) from baseline to 3 months between patients receiving active neurostimulation and those receiving sham stimulation. We calculated that we would need a sample of 40 patients to provide the study with 90% power to detect a 25% difference between treatment groups while allowing for an overall dropout rate of 10%, with a 5% probability of a type I error on the basis of a two-sided Mann–Whitney test. Data from all patients who underwent randomization were analyzed; missing values were imputed with the last observation carried forward.
Secondary end points were the effect of neurostimulation on activities of daily living, the disability score on the Burke–Fahn–Marsden Dystonia Rating Scale, and quality of life (as assessed with the SF-36).28 Exploratory end points were the rate of response (the number of patients with >25% improvement in the movement score on the Burke–Fahn–Marsden Dystonia Rating Scale), scores on the visual analogue scale for dystonia and pain, psychiatric scores (on the Beck Depression and Anxiety Inventories and the Brief Psychiatric Rating Scale), and chronometric tests of walking and tapping at 3 months.
Disease-related ratings after 6 months of active neurostimulation were compared with baseline ratings with the use of the Wilcoxon signed-rank test for matched pairs. All analyses of the secondary and exploratory outcomes were descriptive. The chi-square test was used for categorical data. All statistical tests were two-tailed and were not adjusted for multiple testing. No interim analysis was conducted. Statistical analyses were performed with the JMP statistical package, version 6.0 (SAS Institute).
Results
Between August 2002 and May 2004, 60 patients with dystonic syndromes were referred to the participating centers for deep-brain stimulation. Forty entered the trial and were randomly assigned to the two study groups after surgery (Figure 1Figure 1
Enrollment of Patients and Treatment Assignments.). Their clinical characteristics are summarized in Table 1Table 1
Characteristics of the Study Population..Sixteen patients had segmental dystonia, which always affected the neck in combination with the face, shoulder, arm, or upper trunk. Patients with segmental dystonia, as compared with those with generalized dystonia, were older at the onset of disease (32.6±16.5 vs. 12.3±10.8 years, P<0.001) and at the time of surgery (48.9±13.5 vs. 33.8±10.1 years, P<0.001) and had a shorter duration of disease (16.3±7.1 vs. 21.9±7.9 years, P=0.05). The patients had previously taken multiple medications, which had been discontinued because of inefficacy or adverse effects. Thirty-five patients had received injections of botulinum toxin, but 21 patients had discontinued its use owing to an insufficient control of symptoms. The medications for dystonia that patients were taking at the time of surgery and that provided a partial but insufficient benefit are listed in Table 1.
Randomized Study Period
Three months after randomization, severity scores were significantly lower in the neurostimulation group than in the sham-stimulation group (P<0.001) (Figure 2AFigure 2
Changes in Movement Scores from Baseline to 3 Months and the Effects of 6 Months of Neurostimulation, as Compared with Sham Stimulation.). The movement score improved by a mean of 15.8±14.1 points (a 39.3% reduction in symptoms) in the neurostimulation group, as compared with 1.6±4.0 points (a 4.9% reduction) in the sham-stimulation group (Table 2Table 2
Results of the 3-Month Study Phase.). In the neurostimulation group, 15 patients fulfilled our criterion of a positive response to treatment (>25% reduction in the movement score), as compared with only 3 patients in the sham-stimulation group.Likewise, disability scores improved significantly in the neurostimulation group, by a mean of 3.9±2.9 points (a 37.5% reduction in disability), as compared with a mean of 0.8±1.2 points (8.3%) in the sham-stimulation group (Table 2). Neurostimulation was significantly superior on all symptom subscores of the Burke–Fahn–Marsden Dystonia Rating Scale and most of the disability items. Quality of life, as assessed on the basis of the score for the physical component of the SF-36, improved in the neurostimulation group by 10.1±7.4 points (a 29.8% improvement), which differed significantly from the change in the placebo group (3.8±8.4 points, an 11.4% improvement). The effects on primary and secondary outcomes are summarized in Table 2.
Open-Label Study Extension
Among the patients who had been randomly assigned to the sham-stimulation group during the first 3 months, the movement score on the Burke–Fahn–Marsden Dystonia Rating Scale improved by an average of 12.0±10.0 points (36.8%) after 6 months of continuous neurostimulation (Figure 2B). Among patients originally assigned to receive neurostimulation, the movement score further improved, with a decline from 24.5±22.8 at 3 months to 19.8±15.1 at 6 months, but this additional improvement was not significant (P=0.24).
A comparison of the outcome measures at baseline and after 6 months of neurostimulation was used to assess the magnitude of the treatment effect in the entire study group (Table 3Table 3
Results of the 6-Month Open-Label Extension Phase.). All movement symptoms (except for speech and swallowing), all disability scores, the scores on the physical and mental components of the SF-36, and the global clinical assessments showed pronounced and significant improvements among patients in the neurostimulation group. The severity of dystonia as reflected by the movement score decreased by more than 75% in 5 patients, more than 50% in 18 patients, and more than 25% in 30 patients. Six patients, including one who had the DYT1 mutation in the torsin A gene, had a reduction in symptoms of 25% or less; treatment was considered to have failed in these patients. On average, the decline in the severity of movement symptoms did not differ significantly among 5 patients with primary generalized dystonia who had the DYT1 mutation (−21.7±14.4) and 13 patients who did not have the mutation (−18.8±15.5) (P=0.80). A post hoc comparison of the relative decline in movement scores among the patients with generalized dystonia (a reduction of 41.9±26.5%) and those with segmental dystonia (a reduction of 52.6±23.6%) revealed no significant difference (P=0.41).In the 20 patients receiving ongoing medical treatment for dystonia at enrollment, drug dosages were reduced by an average of 32.1% at 6 months; pharmacotherapy had been entirely discontinued in 5 of the patients. Stimulation measurements remained remarkably stable over time (Table 1).
Neurostimulation significantly decreased depression, as measured by the Beck Depression Inventory, but did not otherwise significantly alter mental or cognitive status (as measured by the Mattis Dementia Rating Scale, the Beck Anxiety Inventory, and the Brief Psychiatric Rating Scale) (Table 3).
Adverse Events
During the initial 3-month randomized phase of the study, nine adverse events were reported in eight patients, of which six events occurred in the neurostimulation group and three in the sham-stimulation group (Table 4Table 4
Adverse Events.). Most of the events were well-known complications of the surgical procedure. Infection at the stimulator site, which occurred in three patients, was the most frequent source of perioperative complications, requiring the temporary removal of the implant in two patients. All adverse events during the randomized phase resolved without permanent sequelae.During the open-label extension phase, 11 patients had a total of 13 adverse events (Table 4). Dysarthria (manifested as slurred but understandable speech), the most common event, occurred in five patients (12%). The adverse events during the extension phase were typically related to stimulation and resolved or improved by changing the stimulation measures. Dysarthria in one patient and dysesthesias in two patients persisted despite adjustments in neurostimulation and were accepted as permanent side effects because the best possible improvement of dystonia could not be achieved without the side effects. In one patient who had mild diabetes, a recurrent infection led to permanent removal of the neurostimulation system shortly after completion of the study.
Discussion
In this 3-month, randomized trial with a sham control, we evaluated the effects of bilateral pallidal deep-brain stimulation for primary generalized and segmental dystonia. We found that 3 months of neurostimulation led to a reduction in the severity of dystonia as reflected by the movement score (a 39% improvement), a reduction in disability (38%), and an improvement in the physical aspects of the quality of life (30%); these improvements were significantly superior to those associated with sham stimulation. Patients who were initially assigned to the sham-stimulation group were switched to neurostimulation after 3 months, and similar benefits were observed across the entire study group after 6 months of continuous neurostimulation, with an average improvement in the movement score of 46%, as compared with baseline. Half the patients had more than a 50% reduction in symptoms. This symptomatic benefit translated into significant improvements in all activities of daily living, as assessed with the Burke–Fahn–Marsden Dystonia Rating Scale, and in significant improvement in the physical and mental dimensions of quality of life, as measured by the SF-36.
The benefits were evident despite the relatively short follow-up period. Previous studies have shown a delayed and progressive course of reduction in dystonia with pallidal neurostimulation. This divergence may reflect different clinical features of dystonia that were not adequately captured by current clinical rating scales. We saw first signs of improvement in mobile dystonia within hours to days after initiating effective neurostimulation, whereas fixed dystonic postures were more resistant and often continued to improve beyond the study period. Although a 6-month follow-up period may have been too short to assess the full range of improvement in all aspects of dystonia, our results closely match those of the only other prospective study on pallidal deep-brain stimulation for primary generalized dystonia, which reported an average 51% reduction in the movement score after 12 months.10
The clinical significance of the benefits of neurostimulation that we observed were greater than was the effect of high-dosage trihexyphenidyl, the most potent drug for the treatment of dystonia.32 In this crossover trial for generalized dystonia, the average difference in scores on the Burke–Fahn–Marsden Dystonia Rating Scale between placebo and trihexyphenidyl was 6.9 points (25%), and only 19% of the patients had a reduction in scores of more than 50% with treatment.
Patients with generalized or segmental dystonia had a similar symptomatic benefit after 6 months of neurostimulation, which suggests that the two conditions are equally likely to respond favorably. Most important for the patients with segmental dystonia was the reduction of axial symptoms by an average of 50%, because cervical dystonia was the predominant clinical symptom in all cases. This observation may have important implications when one is considering neurostimulation for patients with focal cervical dystonia that is inadequately controlled by botulinum toxin.
Like other investigators,16,33 we found a variable response to therapy among patients, but no single factor among the baseline variables predicted the magnitude of improvement. After 6 months of neurostimulation, 17% of patients had a poor response (defined as ≤25% improvement or a worsening of the condition), despite correct positioning of electrodes, as verified by postoperative neuroimaging. One of these patients had the DYT1 mutation. The mean improvement among patients with generalized dystonia who had the DYT1 mutation and among those who did not have the mutation was the same in the open-label extension phase (38% in each group) — a finding that does not corroborate a previous hypothesis that the presence of this mutation would increase the therapeutic benefit.33 Such factors as the age at the time of the onset of disease, the duration of disease, and the distribution of dystonia were not related to the outcome.
We did not observe changes in cognitive status associated with bilateral pallidal deep-brain stimulation. In contrast to a recent report suggesting an increased risk of suicide after pallidal neurostimulation for dystonia,34 mood actually improved significantly among the patients in our study, and we found no behavioral abnormalities. Device-related complications — including infections at the stimulator site, seroma, and lead dislodgment or breakage — amounted to 18% and were more frequent than previously reported for neurostimulation in Parkinson's disease.35,36 One reason could be that the implant undergoes more mechanical stress in patients with dystonia, suggesting a need for an improvement in the device for patients with this condition.10,37 None of our patients had intracranial hemorrhage, but the assessment of such an infrequent surgical complication may require a larger series of patients. Neurologic adverse events related to high-frequency stimulation were not severe and usually resolved with adequate programming, except for mild dysarthria in one patient and mild dysesthesia in two patients.
In conclusion, in this randomized comparison of the effects of neurostimulation and sham stimulation, we found that bilateral high-frequency stimulation of the internal globus pallidus is efficacious in the reduction of movement impairment and disability in patients with primary generalized or segmental dystonia. Extended follow-up studies are now needed to assess the long-term efficacy and safety of this treatment.
Videos showing four patients with dystonia are available with the full text of this article at www.nejm.org.
Supported by an unrestricted research grant (to Drs. Volkmann and Benecke) from Medtronic, by a grant (FK-01GI0201) from the German Ministry of Research and Technology, and by grants from the universities involved in the study.
Drs. Kupsch, Müller, Schneider, Eisner, Deuschl, Krause, Schnitzler, Tronnier, Voges, and Volkmann report having received speaking fees from Medtronic; Drs. Kupsch and Volkmann, consulting fees from Medtronic; and Drs. Kupsch, Benecke, Krause, and Volkmann, grant support from Medtronic. No other potential conflict of interest relevant to this article was reported.
We thank Drs. C. Oehlwein (Gera, Germany), G. Reichel (Zwickau, Germany), and Dr. A. Schneider (Linz, Austria) for their referral of patients for the trial.
Source Information
From Charité Universitätsmedizin Berlin, Campus Virchow, Berlin (A.K., T.T., G.-H.S.); University of Rostock, Rostock (R.B., A.W.); Ernst Moritz Arndt University, Greifswald (J.-U.M.); Christian Albrechts University, Kiel (G.D., M.O.P., J. Volkmann); University of Münster, Münster (J.V.-H., A.B.); University of Heidelberg, Heidelberg (M.K., V.T.); Heinrich Heine University, Düsseldorf (A.S.); University of Cologne, Cologne (J. Voges); University of Freiburg, Freiburg (G.N., J. Vesper); and University of Würzburg, Würzburg (M.N.) — all in Germany; Medical University Innsbruck, Innsbruck, Austria (J.M., W.P., W.E.); and University of Oslo, Oslo (I.M.S., G.K.R.).
Address reprint requests to Dr. Volkmann at the Department of Neurology, Christian Albrechts University, Schittenhelmstr. 10, D-24105 Kiel, Germany, or at j.volkmann@neurologie.uni-kiel.de.
The members of the Deep-Brain Stimulation for Dystonia Study Group are listed in the Appendix.
Appendix
Members of the Deep Brain Stimulation for Dystonia Study Group were as follows: Study Design and Principal Investigators — R. Benecke, J. Volkmann; Statistical Adviser — L. Gierl, Institute for Medical Informatics and Statistics, University of Rostock, Rostock, Germany; External Raters — K.P. Bathia, Institute of Neurology, Queen Square, London, and J.L. Vitek, Center for Neurological Restoration, Cleveland Clinic, Cleveland; Writing Committee — R. Benecke, G. Deuschl, A. Kupsch, J. Müller, M. Pinsker, W. Poewe, J. Volkmann; Neurosurgical Monitoring — H.M. Mehdorn, Department of Neurosurgery, Christian Albrechts University, Kiel, Germany.
Investigators were associated with the following institutions: Charité Universitätsmedizin Berlin, Campus Virchow, Berlin — D. Gruber, A. Kivi, A.A. Kühn, A. Kupsch, T. Trottenberg, G.-H. Schneider; Heinrich Heine University, Düsseldorf — A. Schnitzler, L. Timmermann, L. Wojtecki; University of Cologne, Cologne — V. Sturm, J. Voges; University of Freiburg, Freiburg — G. Nikkhah, T. Prokop, J. Vesper; Ernst Moritz Arndt University, Greifswald — J.-U. Müller; University of Heidelberg, Heidelberg — M. Kloss, M. Krause, V. Tronnier; Christian Albrechts University, Kiel — G. Deuschl, J. Herzog, M.M. Mehdorn, M.O. Pinsker, M. Pötter, F. Steigerwald, J. Volkmann; University of Münster, Münster — H.-W. Boothe, A. Brentrup, J. Vollmer-Haase; University of Rostock, Rostock — R. Benecke, M. Wittstock, A. Wolters; University of Würzburg, Würzburg — M. Naumann, A. Schramm — all in Germany; Medical University Innsbruck, Innsbruck, Austria: W. Eisner, T. Fiegele, J. Müller, W. Poewe; and University of Oslo, Oslo — G.K. Roeste, I.M. Skogseid.
- References
References
1
Klein C ,Ozelius LJ . Dystonia: clinical features, genetics, and treatment. Curr Opin Neurol 2002;15:491-497
CrossRef | Web of Science | Medline2
Fahn S ,Bressman SB ,Marsden CD . Classification of dystonia. Adv Neurol 1998;78:1-10
Medline3
Balash Y ,Giladi N . Efficacy of pharmacological treatment of dystonia: evidence-based review including meta-analysis of the effect of botulinum toxin and other cure options. Eur J Neurol 2004;11:361-370
CrossRef | Web of Science | Medline4
Dressler D . Clinical presentation and management of antibody-induced failure of botulinum toxin therapy. Mov Disord 2004;19:Suppl 8:S92-S100
CrossRef | Web of Science | Medline5
Horn S, Comella CL. Treatment of dystonia. In: Jankovic JJ, Tolosa E, eds. Parkinson's disease and movement disorders. Philadelphia: Lippincott Williams & Wilkins, 2002:358-64.
6
Benabid AL ,Koudsie A ,Benazzouz A , et al. Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease: extension to new indications such as dystonia and epilepsy. J Neurol 2001;248:Suppl 3:III-37
CrossRef7
Coubes P ,Roubertie A ,Vayssiere N ,Hemm S ,Echenne B . Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus. Lancet 2000;355:2220-2221
CrossRef | Web of Science | Medline8
Cif L ,El Fertit H ,Vayssiere N , et al. Treatment of dystonic syndromes by chronic electrical stimulation of the internal globus pallidus. J Neurosurg Sci 2003;47:52-55
Medline9
Kumar R ,Dagher A ,Hutchison WD ,Lang AE ,Lozano AM . Globus pallidus deep brain stimulation for generalized dystonia: clinical and PET investigation. Neurology 1999;53:871-874
Web of Science | Medline10
Vidailhet M ,Vercueil L ,Houeto J-L , et al. Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. N Engl J Med 2005;352:459-467
Full Text | Web of Science | Medline11
Tronnier VM ,Fogel W . Pallidal stimulation for generalized dystonia: report of three cases. J Neurosurg 2000;92:453-456
CrossRef | Web of Science | Medline12
Halbig TD ,Gruber D ,Kopp UA ,Schneider GH ,Trottenberg T ,Kupsch A . Pallidal stimulation in dystonia: effects on cognition, mood, and quality of life. J Neurol Neurosurg Psychiatry 2005;76:1713-1716
CrossRef | Web of Science | Medline13
Yianni J ,Bain P ,Giladi N , et al. Globus pallidus internus deep brain stimulation for dystonic conditions: a prospective audit. Mov Disord 2003;18:436-442
CrossRef | Web of Science | Medline14
Krauss JK ,Loher TJ ,Weigel R ,Capelle HH ,Weber S ,Burgunder JM . Chronic stimulation of the globus pallidus internus for treatment of non-dYT1 generalized dystonia and choreoathetosis: 2-year follow up. J Neurosurg 2003;98:785-792
CrossRef | Web of Science | Medline15
Zorzi G ,Marras C ,Nardocci N , et al. Stimulation of the globus pallidus internus for childhood-onset dystonia. Mov Disord 2005;20:1194-1200
CrossRef | Web of Science | Medline16
Krause M ,Fogel W ,Kloss M ,Rasche D ,Volkmann J ,Tronnier V . Pallidal stimulation for dystonia. Neurosurgery 2004;55:1361-1370
CrossRef | Web of Science | Medline17
Bereznai B ,Steude U ,Seelos K ,Botzel K . Chronic high-frequency globus pallidus internus stimulation in different types of dystonia: a clinical, video, and MRI report of six patients presenting with segmental, cervical, and generalized dystonia. Mov Disord 2002;17:138-144
CrossRef | Web of Science | Medline18
Houser M ,Waltz T . Meige syndrome and pallidal deep brain stimulation. Mov Disord 2005;20:1203-1205
CrossRef | Web of Science | Medline19
Bittar RG ,Yianni J ,Wang S , et al. Deep brain stimulation for generalised dystonia and spasmodic torticollis. J Clin Neurosci 2005;12:12-16
CrossRef | Web of Science | Medline20
Chou KL ,Hurtig HI ,Jaggi JL ,Baltuch GH . Bilateral subthalamic nucleus deep brain stimulation in a patient with cervical dystonia and essential tremor. Mov Disord 2005;20:377-380
CrossRef | Web of Science | Medline21
Eltahawy HA ,Saint-Cyr J ,Poon YY ,Moro E ,Lang AE ,Lozano AM . Pallidal deep brain stimulation in cervical dystonia: clinical outcome in four cases. Can J Neurol Sci 2004;31:328-332
Web of Science | Medline22
Foote KD ,Sanchez JC ,Okun MS . Staged deep brain stimulation for refractory craniofacial dystonia with blepharospasm: case report and physiology. Neurosurgery 2005;56:E415-E415
CrossRef | Web of Science | Medline23
Islekel S ,Zileli M ,Zileli B . Unilateral pallidal stimulation in cervical dystonia. Stereotact Funct Neurosurg 1999;72:248-252
CrossRef | Web of Science | Medline24
Krauss JK . Deep brain stimulation for cervical dystonia. J Neurol Neurosurg Psychiatry 2003;74:1598-1598
CrossRef | Web of Science | Medline25
Greene P . Deep-brain stimulation for generalized dystonia. N Engl J Med 2005;352:498-500
Full Text | Web of Science | Medline26
Truong D ,Duane DD ,Jankovic J , et al. Efficacy and safety of botulinum type A toxin (Dysport) in cervical dystonia: results of the first US randomized, double-blind, placebo-controlled study. Mov Disord 2005;20:783-791
CrossRef | Web of Science | Medline27
Burke RE ,Fahn S ,Marsden CD ,Bressman SB ,Moskowitz C ,Friedman J . Validity and reliability of a rating scale for the primary torsion dystonias. Neurology 1985;35:73-77
Web of Science | Medline28
Ware JE Jr ,Sherbourne CD . The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473-483
CrossRef | Web of Science | Medline29
Matthis S. Mental status examination for organic mental syndrome in the elderly patient. In: Bellak L, Karatsu T, eds. Geriatric psychiatry: a handbook for psychiatrists and primary care physicians. New York: Grune and Stratton, 1976:77-121.
30
Flemenbaum A ,Zimmermann RL . Inter- and intra-rater reliability of the Brief Psychiatric Rating Scale. Psychol Rep 1973;32:783-792
CrossRef | Web of Science | Medline31
Beck A. Beck depression inventory (BDI). San Antonio, TX: Psychological Corporation, 1997.
32
Burke RE ,Fahn S ,Marsden CD . Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl. Neurology 1986;36:160-164
Web of Science | Medline33
Vercueil L ,Krack P ,Pollak P . Results of deep brain stimulation for dystonia: a critical reappraisal. Mov Disord 2002;17:Suppl 3:S89-S93
CrossRef | Web of Science | Medline34
Foncke EM ,Schuurman PR ,Speelman JD . Suicide after deep brain stimulation of the internal globus pallidus for dystonia. Neurology 2006;66:142-143
CrossRef | Web of Science | Medline35
Goodman RR ,Kim B ,McClelland S III , et al. Operative techniques and morbidity with subthalamic nucleus deep brain stimulation in 100 consecutive patients with advanced Parkinson's disease. J Neurol Neurosurg Psychiatry 2006;77:12-17
CrossRef | Web of Science | Medline36
Lyons KE ,Wilkinson SB ,Overman J ,Pahwa R . Surgical and hardware complications of subthalamic stimulation: a series of 160 procedures. Neurology 2004;63:612-616
Web of Science | Medline37
Yianni J ,Nandi D ,Shad A ,Bain P ,Gregory R ,Aziz T . Increased risk of lead fracture and migration in dystonia compared with other movement disorders following deep brain stimulation. J Clin Neurosci 2004;11:243-245
CrossRef | Web of Science | Medline
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1
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CrossRef2
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CrossRef3
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CrossRef4
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CrossRef5
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CrossRef6
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CrossRef7
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CrossRef8
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CrossRef9
M. Stamelou, M. J. Edwards, M. Hallett, K. P. Bhatia. (2011) The non-motor syndrome of primary dystonia: clinical and pathophysiological implications. Brain
CrossRef10
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CrossRef11
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CrossRef12
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CrossRef13
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CrossRef14
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CrossRef15
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CrossRef16
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CrossRef17
M. K. Lyons. (2011) Deep Brain Stimulation: Current and Future Clinical Applications. Mayo Clinic Proceedings 86:7, 662-672
CrossRef18
Naomi Lubarr, Susan Bressman. (2011) Treatment of Generalized Dystonia. Current Treatment Options in Neurology 13:3, 274-289
CrossRef19
C. Blahak, H.-H. Capelle, H. Baezner, T. M. Kinfe, M. G. Hennerici, J. K. Krauss. (2011) Battery lifetime in pallidal deep brain stimulation for dystonia. European Journal of Neurology 18:6, 872-875
CrossRef20
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CrossRef21
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CrossRef22
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CrossRef23
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CrossRef24
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CrossRef25
Daniel J. Kuyper, Veronica Parra, Shanae Aerts, Michael S. Okun, Benzi M. Kluger. (2011) Nonmotor manifestations of dystonia: A systematic review. Movement Disorders 26:7, 1206-1217
CrossRef26
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CrossRef27
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CrossRef28
Anthony E. Lang. (2011) Deep brain stimulation for dystonia. Movement Disorders 26:S1, S3-S4
CrossRef29
Elena Moro, Alberto Albanese, Joachim K. Krauss, Leo Verhagen Metman, Marie Vidailhet, Marwan I. Hariz. (2011) Guest Editors' introduction. Movement Disorders 26:S1, S1-S2
CrossRef30
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CrossRef31
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CrossRef32
Laurie J. Ozelius, Naomi Lubarr, Susan B. Bressman. (2011) Milestones in dystonia. Movement Disorders 26:6, 1106-1126
CrossRef33
(2011) Proceedings of the 157 th meeting of the Society of British Neurological Surgeons. British Journal of Neurosurgery 25:2, 148-192
CrossRef34
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CrossRef35
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CrossRef36
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CrossRef37
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CrossRef38
Jose A. Aguilar, Theodor S. Vesagas, Roland Dominic Jamora, Rosalia A. Teleg, Lourdes Ledesma, Raymond L. Rosales, Hubert H. Fernandez, Lillian V. Lee. (2011) The Promise of Deep Brain Stimulation in X-Linked Dystonia Parkinsonism. International Journal of Neuroscience 121:S1, 57-63
CrossRef39
Erin N. Kiehna, Robert M. Starke, Nader Pouratian, Aaron S. Dumont. (2011) Standards for reporting randomized controlled trials in neurosurgery. Journal of Neurosurgery 114:2, 280-285
CrossRef40
Nova B Thani, Arul Bala, Thomas E Kimber, Christopher R P Lind. (2011) High-frequency Pallidal Stimulation for Camptocormia in Parkinsonʼs disease. Neurosurgery1
CrossRef41
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CrossRef42
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CrossRef43
Thomas L. Ellis. (2011) Dystonia and the Role of Deep Brain Stimulation. ISRN Surgery 2011, 1-5
CrossRef44
Stanley Fahn, Joseph Jankovic, Mark Hallett. 2011. Surgical treatment of Parkinson disease and other movement disorders. , 157-182.
CrossRef45
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CrossRef46
Stanley Fahn, Joseph Jankovic, Mark Hallett. 2011. Treatment of dystonia. , 293-310.
CrossRef47
John Yianni, Alexander L. Green, Tipu Z. Aziz. 2011. Surgical Treatment of Dystonia. , 573-589.
CrossRef48
M. Ensslen, J.-H. Mehrkens, K. Bötzel, A.S. Schröder, W. Müller-Felber, F. Heinen, I. Borggräfe. (2011) Dystonien im Kindesalter. Monatsschrift Kinderheilkunde 159:1, 17-24
CrossRef49
A. Albanese, F. Asmus, K. P. Bhatia, A. E. Elia, B. Elibol, G. Filippini, T. Gasser, J. K. Krauss, N. Nardocci, A. Newton, J. Valls-Solé. (2011) EFNS guidelines on diagnosis and treatment of primary dystonias. European Journal of Neurology 18:1, 5-18
CrossRef50
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CrossRef51
Marian L. Evatt, Alan Freeman, Stewart Factor. 2011. Adult-onset dystonia. , 481-511.
CrossRef52
Karl Nowak, Eilhard Mix, Jan Gimsa, Ulf Strauss, Kiran Kumar Sriperumbudur, Reiner Benecke, Ulrike Gimsa. (2011) Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation. Parkinson's Disease 2011, 1-19
CrossRef53
Hong Souk Park, Eun Sook Park, Jin Woo Chang, Ki Seok Lee, Young Joo Suh, Sung-Rae Cho. (2011) Combined Therapy of Orthopedic Surgery after Deep Brain Stimulation in Cerebral Palsy Mixed Type - A Case Report -. Annals of Rehabilitation Medicine 35:5, 742
CrossRef54
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CrossRef55
Erwin B. Montgomery. 2011. The Electrode – Principles of the Neural Interface. , 169-192.
CrossRef56
Yakov Gologorsky, Ron Alterman. 2011. Cerebral – Deep. , 47-72.
CrossRef57
Lutz M. Weise, Gerd H. Schneider, Andreas Kupsch, Jens Haumesser, Karl T. Hoffmann. (2010) Postoperative MRI examinations in patients treated by deep brain stimulation using a non-standard protocol. Acta Neurochirurgica 152:12, 2021-2027
CrossRef58
Jelle Demeestere, Wim Vandenberghe. (2010) Experimental Surgical Therapies for Huntington's Disease. CNS Neuroscience & Therapeuticsno-no
CrossRef59
Ninith Kartha. (2010) Therapeutic Challenges in Dystonia. Neurologic Clinics 28:4, 927-940
CrossRef60
A. Albanese, F. Asmus, A. Berardelli, K. Bhatia, A. E. Elia, B. Elibol, G. Filippini, T. Gasser, J. K. Krauss, N. Nardocci, A. Newton, J. Valls-Solé, M. Vidailhet. 2010. Diagnosis and Treatment of Primary (Idiopathic) Dystonia. , 191-206.
CrossRef61
Paul Krack, Marwan I. Hariz, Christelle Baunez, Jorge Guridi, Jose A. Obeso. (2010) Deep brain stimulation: from neurology to psychiatry?. Trends in Neurosciences 33:10, 474-484
CrossRef62
Luigi M. Romito, Antonio E. Elia, Angelo Franzini, Orso Bugiani, Alberto Albanese. (2010) Low-Voltage Bilateral Pallidal Stimulation for Severe Meige Syndrome in a Patient With Primary Segmental Dystonia. Neurosurgery 67, onsE308
CrossRef63
Jerrold L. Vitek, Kelly E. Lyons, Roy Bakay, Alim-Louis Benabid, Guenther Deuschl, Mark Hallett, Roger Kurlan, Joseph J. Pancrazio, Ali Rezai, Benjamin L. Walter, Anthony E. Lang. (2010) Standard guidelines for publication of deep brain stimulation studies in Parkinson's disease (Guide4DBS-PD). Movement Disorders 25:11, 1530-1537
CrossRef64
Doreen Gruber, Andrea A. Kühn, Thomas Schoenecker, Anatol Kivi, Thomas Trottenberg, Karl-Titus Hoffmann, Alireza Gharabaghi, Ute A. Kopp, Gerd-Helge Schneider, Christine Klein, Friedrich Asmus, Andreas Kupsch. (2010) Pallidal and thalamic deep brain stimulation in myoclonus-dystonia. Movement Disorders 25:11, 1733-1743
CrossRef65
Vivianne L. Tawfik, Su-Youne Chang, Frederick L. Hitti, David W. Roberts, James C. Leiter, Svetlana Jovanovic, Kendall H. Lee. (2010) Deep Brain Stimulation Results in Local Glutamate and Adenosine Release. Neurosurgery 67:2, 367-375
CrossRef66
Adam P. Burdick, Hubert H. Fernandez, Michael S. Okun, Yueh-Yun Chi, Charles Jacobson, Kelly D. Foote. (2010) Relationship between higher rates of adverse events in deep brain stimulation using standardized prospective recording and patient outcomes. Neurosurgical FOCUS 29:2, E4
CrossRef67
Mark K. Lyons, Barry D. Birch, Renee A. Hillman, Orland K. Boucher, Virgilio Gerald H. Evidente. (2010) Long-term follow-up of deep brain stimulation for Meige syndrome. Neurosurgical FOCUS 29:2, E5
CrossRef68
Hans-Holger Capelle, Christian Blahak, Christoph Schrader, Hansjörg Baezner, Thomas M. Kinfe, Jan Herzog, Reinhard Dengler, Joachim K. Krauss. (2010) Chronic deep brain stimulation in patients with tardive dystonia without a history of major psychosis. Movement Disorders 25:10, 1477-1481
CrossRef69
Daniel Harnack, Andreas Kupsch. (2010) The Impact of Subthalamic Deep Brain Stimulation on Nigral Neuroprotection-Myth or Reality?. Neuromodulation: Technology at the Neural Interface 13:3, 160-167
CrossRef70
J. D. Speelman, M. F. Contarino, P. R. Schuurman, M. A. J. Tijssen, R. M. A. De Bie. (2010) Deep brain stimulation for dystonia: patient selection and outcomes. European Journal of Neurology 17, 102-106
CrossRef71
J. K. Krauss. (2010) Surgical treatment of dystonia. European Journal of Neurology 17, 97-101
CrossRef72
J. Voges, J.K. Krauss. (2010) Neurochirurgische und technische Aspekte der tiefen Hirnstimulation. Der Nervenarzt 81:6, 702-710
CrossRef73
Kelly L. Collins, Emily M. Lehmann, Parag G. Patil. (2010) Deep brain stimulation for movement disorders. Neurobiology of Disease 38:3, 338-345
CrossRef74
L. Timmermann, J. Volkmann. (2010) Tiefe Hirnstimulation zur Behandlung von Dystonie und Tremor. Der Nervenarzt 81:6, 680-687
CrossRef75
Zinovia Kefalopoulou, Anna Paschali, Elli Markaki, John Ellul, Elisabeth Chroni, Pavlos Vassilakos, Constantine Constantoyannis. (2010) Regional cerebral blood flow changes induced by deep brain stimulation in secondary dystonia. Acta Neurochirurgica 152:6, 1007-1014
CrossRef76
Niels Allert, Daniela Kelm, Christian Blahak, Hans-Holger Capelle, Joachim K. Krauss. (2010) Stuttering induced by thalamic deep brain stimulation for dystonia. Journal of Neural Transmission 117:5, 617-620
CrossRef77
Elli Markaki, Zinovia Kefalopoulou, Miltiadis Georgiopoulos, Anna Paschali, Constantine Constantoyannis. (2010) Meige's syndrome: A cranial dystonia treated with bilateral pallidal deep brain stimulation. Clinical Neurology and Neurosurgery 112:4, 344-346
CrossRef78
Nada Yousif, Nuri Purswani, Richard Bayford, Dipankar Nandi, Peter Bain, Xuguang Liu. (2010) Evaluating the impact of the deep brain stimulation induced electric field on subthalamic neurons: A computational modelling study. Journal of Neuroscience Methods 188:1, 105-112
CrossRef79
Mario Manca, Martina Mancini, Giovanni Ferraresi, Lorenzo Chiari, Mariachiara Sensi, Michele Cavallo, Rocco Quatrale. (2010) Effect of Globus Pallidus internus stimulation on gait in multifocal dystonia: A case study. Clinical Neurophysiology 121:3, 453-456
CrossRef80
M. Carbon, M. Argyelan, C. Habeck, M. F. Ghilardi, T. Fitzpatrick, V. Dhawan, M. Pourfar, S. B. Bressman, D. Eidelberg. (2010) Increased sensorimotor network activity in DYT1 dystonia: a functional imaging study. Brain 133:3, 690-700
CrossRef81
L. Timmermann, K. A. M. Pauls, K. Wieland, R. Jech, G. Kurlemann, N. Sharma, S. S. Gill, C. A. Haenggeli, S. J. Hayflick, P. Hogarth, K. L. Leenders, P. Limousin, C. J. Malanga, E. Moro, J. L. Ostrem, F. J. Revilla, P. Santens, A. Schnitzler, S. Tisch, F. Valldeoriola, J. Vesper, J. Volkmann, D. Woitalla,, S. Peker. (2010) Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation. Brain 133:3, 701-712
CrossRef82
Ingo Borggraefe, Jan Hinnerk Mehrkens, Mila Telegravciska, Steffen Berweck, Kai Bötzel, Florian Heinen. (2010) Bilateral pallidal stimulation in children and adolescents with primary generalized dystonia – Report of six patients and literature-based analysis of predictive outcomes variables. Brain and Development 32:3, 223-228
CrossRef83
Laura Cif, Xavier Vasques, Victoria Gonzalez, Patrice Ravel, Brigitte Biolsi, Gwenaelle Collod-Beroud, Sylvie Tuffery-Giraud, Hassan Elfertit, Mireille Claustres, Philippe Coubes. (2010) Long-term follow-up of DYT1 dystonia patients treated by deep brain stimulation: An open-label study. Movement Disorders 25:3, 289-299
CrossRef84
Friederike Sixel-Döring, Claudia Trenkwalder, Christoph Kappus, Dieter Hellwig. (2010) Skin complications in deep brain stimulation for Parkinson’s disease: frequency, time course, and risk factors. Acta Neurochirurgica 152:2, 195-200
CrossRef85
Monica M. Kurtis, Marta San Luciano, Qiping Yu, Robert R. Goodman, Blair Ford, Deborah Raymond, Seth L. Pullman, Rachel Saunders-Pullman. (2010) Clinical and neurophysiological improvement of SGCE myoclonus–dystonia with GPi deep brain stimulation. Clinical Neurology and Neurosurgery 112:2, 149-152
CrossRef86
Harvey S. Singer, Jonathan W. Mink, Donald L. Gilbert, Joseph Jankovic. 2010. Dystonia. , 97-109.
CrossRef87
A.M. Lozano. 2010. Surgery for Movement Disorders, Overview, Including History. , 199-200.
CrossRef88
Thomas Wichmann, Mahlon R. DeLong. 2010. Deep-Brain Stimulation for Neurologic and Psychiatric Disorders. , 659-681.
CrossRef89
Ju-Young Ghang, Myung-Ki Lee, Sung-Man Jun, Chang-Ghu Ghang. (2010) Outcome of Pallidal Deep Brain Stimulation in Meige Syndrome. Journal of Korean Neurosurgical Society 48:2, 134
CrossRef90
Frandy Susatia, Irene A. Malaty, Kelly D. Foote, Samuel S. Wu, Pamela R. Zeilman, Mitushi Mishra, Ramon L. Rodriguez, Ihtsham ul Haq, Charles E. Jacobson, Anqi Sun, Michael S. Okun. (2010) An evaluation of rating scales utilized for deep brain stimulation for dystonia. Journal of Neurology 257:1, 44-58
CrossRef91
Tipu Z. Aziz, Alexander L. Green. (2009) Dystonia: a surgeon's perspective. Parkinsonism & Related Disorders 15, S75-S80
CrossRef92
Fabian Klostermann, Michael Wahl, Jesko Schomann, Andreas Kupsch, Gabriel Curio, Frank Marzinzik. (2009) Thalamo-cortical processing of near-threshold somatosensory stimuli in humans. European Journal of Neuroscience 30:9, 1815-1822
CrossRef93
Giovanna Zorzi, Federica Zibordi, Barbara Garavaglia, Nardo Nardocci. (2009) Early onset primary dystonia. European Journal of Paediatric Neurology 13:6, 488-492
CrossRef94
Nada Yousif, Xuguang Liu. (2009) Investigating the depth electrode–brain interface in deep brain stimulation using finite element models with graded complexity in structure and solution. Journal of Neuroscience Methods 184:1, 142-151
CrossRef95
Mariachiara Sensi, Michele A. Cavallo, Rocco Quatrale, Silvio Sarubbo, Sara Biguzzi, Cristian Lettieri, Jay G. Capone, Valeria Tugnoli, Maria Rosaria Tola, Roberto Eleopra. (2009) Pallidal stimulation for segmental dystonia: Long term follow up of 11 consecutive patients. Movement Disorders 24:12, 1829-1835
CrossRef96
René Reese, Giselle Charron, Agnès Nadjar, Incarnation Aubert, Marie-Laure Thiolat, Melanie Hamann, Angelika Richter, Erwan Bezard, Wassilios G Meissner. (2009) High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster. Neurobiology of Disease 35:3, 399-405
CrossRef97
Paolo Gubellini, Pascal Salin, Lydia Kerkerian-Le Goff, Christelle Baunez. (2009) Deep brain stimulation in neurological diseases and experimental models: From molecule to complex behavior. Progress in Neurobiology 89:1, 79-123
CrossRef98
Joseph Jankovic. (2009) Peripherally Induced Movement Disorders. Neurologic Clinics 27:3, 821-832
CrossRef99
Benzi M. Kluger, Olga Klepitskaya, Michael S. Okun. (2009) Surgical Treatment of Movement Disorders. Neurologic Clinics 27:3, 633-677
CrossRef100
Uwe Walter, Alexander Wolters, Matthias Wittstock, Reiner Benecke, Henry W. Schroeder, Jan-Uwe Müller. (2009) Deep brain stimulation in dystonia: Sonographic monitoring of electrode placement into the globus pallidus internus. Movement Disorders 24:10, 1538-1541
CrossRef101
Nasir Raza Awan, Andres Lozano, Clement Hamani. (2009) Deep brain stimulation: current and future perspectives. Neurosurgical FOCUS 27:1, E2
CrossRef102
M. O. Pinsker, J. Volkmann, D. Falk, J. Herzog, F. Steigerwald, G. Deuschl, H. M. Mehdorn. (2009) Deep brain stimulation of the internal globus pallidus in dystonia: target localisation under general anaesthesia. Acta Neurochirurgica 151:7, 751-758
CrossRef103
C. Schrader, R. Benecke, G. Deuschl, R. Hilker, A. Kupsch, M. Lange, F. Sixel-Döring, L. Timmermann, J. Volkmann, W. Fogel. (2009) Tiefe Hirnstimulation bei Dystonie. Der Nervenarzt 80:6, 656-661
CrossRef104
Adrian Mundt, Julia Klein, Daphna Joel, Andreas Heinz, Anais Djodari-Irani, Daniel Harnack, Andreas Kupsch, Helmut Orawa, Georg Juckel, Rudolf Morgenstern, Christine Winter. (2009) High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. European Journal of Neuroscience 29:12, 2401-2412
CrossRef105
Tina Islam, Andreas Kupsch, Harald Bruhn, Christian Scheurig, Sein Schmidt, Karl-Titus Hoffmann. (2009) Decreased bilateral cortical representation patterns in writer’s cramp: a functional magnetic resonance imaging study at 3.0 T. Neurological Sciences 30:3, 219-226
CrossRef106
P. F. Katsakiori, Z. Kefalopoulou, E. Markaki, A. Paschali, J. Ellul, G. C. Kagadis, E. Chroni, C. Constantoyannis. (2009) Deep brain stimulation for secondary dystonia: results in 8 patients. Acta Neurochirurgica 151:5, 473-478
CrossRef107
C. Stephani, M.A. Nitsche, W. Paulus. (2009) Invasive Hirnstimulationsverfahren in der Epilepsietherapie. Zeitschrift für Epileptologie 22:2, 80-88
CrossRef108
Xavier Vasques, Laura Cif, Victoria Gonzalez, Claire Nicholson, Philippe Coubes. (2009) Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation. Movement Disorders 24:6, 846-853
CrossRef109
Alexis M. Kuncel, Dennis A. Turner, Laurie J. Ozelius, Paul E. Greene, Warren M. Grill, Mark A. Stacy. (2009) Myoclonus and tremor response to thalamic deep brain stimulation parameters in a patient with inherited myoclonus–dystonia syndrome. Clinical Neurology and Neurosurgery 111:3, 303-306
CrossRef110
J. Volkmann. (2009) Finding the best way of stimulating the brain. European Journal of Neurology 16:4, 442-443
CrossRef111
E. Moro, P. Piboolnurak, T. Arenovich, S. W. Hung, Y.-Y. Poon, A. M. Lozano. (2009) Pallidal stimulation in cervical dystonia: clinical implications of acute changes in stimulation parameters. European Journal of Neurology 16:4, 506-512
CrossRef112
Kiyoka Kinugawa, Marie Vidailhet, Fabienne Clot, Emmanuelle Apartis, David Grabli, Emmanuel Roze. (2009) Myoclonus-dystonia: An update. Movement Disorders 24:4, 479-489
CrossRef113
Xavier Vasques, Laura Cif, Olivier Hess, Sophie Gavarini, Gerard Mennessier, Philippe Coubes. (2009) Prognostic value of globus pallidus internus volume in primary dystonia treated by deep brain stimulation. Journal of Neurosurgery 110:2, 220-228
CrossRef114
Beka Serdans. (2009) DBS. Journal of Neuroscience Nursing 41:1, 53-56
CrossRef115
S. Elizabeth Zauber, Nidhi Watson, Cynthia L. Comella, Roy A. E. Bakay, Leo Verhagen Metman. (2009) Stimulation-induced parkinsonism after posteroventral deep brain stimulation of the globus pallidus internus for craniocervical dystonia. Journal of Neurosurgery 110:2, 229-233
CrossRef116
Alim Louis Benabid, Stephan Chabardes, John Mitrofanis, Pierre Pollak. (2009) Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. The Lancet Neurology 8:1, 67-81
CrossRef117
Seong-Gyu Jeong, Myung-Ki Lee, Ju-Young Kang, Sung-Man Jun, Won-Ho Lee, Chang-Ghu Ghang. (2009) Pallidal Deep Brain Stimulation in Primary Cervical Dystonia with Phasic Type : Clinical Outcome and Postoperative Course. Journal of Korean Neurosurgical Society 46:4, 346
CrossRef118
Hans-Holger Capelle, Joachim K. Krauss. (2009) Neuromodulation in Dystonia: Current Aspects of Deep Brain Stimulation. Neuromodulation: Technology at the Neural Interface 12:1, 8-21
CrossRef119
Patric Blomstedt, Marwan I. Hariz, Stephen Tisch, Monica Holmberg, Tommy A. Bergenheim, Lars Forsgren. (2009) A family with a hereditary form of torsion dystonia from Northern Sweden treated with bilateral pallidal deep brain stimulation. Movement DisordersNA-NA
CrossRef120
David Grabli, Claire Ewenczyk, Maria-Clara Coelho-Braga, Christelle Lagrange, Valerie Fraix, Philippe Cornu, Alim-Louis Benabid, Marie Vidailhet, Pierre Pollak. (2009) Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia. Movement DisordersNA-NA
CrossRef121
Thomas Fiegele, Gudrun Feuchtner, Florian Sohm, Richard Bauer, Jürgen Volker Anton, Thaddäus Gotwald, Klaus Twerdy, Wilhelm Eisner. (2008) Accuracy of stereotactic electrode placement in deep brain stimulation by intraoperative computed tomography. Parkinsonism & Related Disorders 14:8, 595-599
CrossRef122
Matthis Synofzik, Thomas E. Schlaepfer. (2008) Stimulating personality: Ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes. Biotechnology Journal 3:12, 1511-1520
CrossRef123
Mi J. Kim, Sang R. Jeon, Han-Wook Yoo, Gu-Hwan Kim, Myoung C. Lee, Sun J. Chung. (2008) Effect of thalamotomy on focal hand dystonia in a family with DYT1 mutation. Movement Disorders 23:15, 2251-2255
CrossRef124
Mathieu Anheim, Laurent Vercueil, Valerie Fraix, Stéphan Chabardès, Eric Seigneuret, Paul Krack, Alim-Louis Benabid, Marie Vidailhet, Pierre Pollak. (2008) Early stimulation of DYT1 primary generalized dystonia prevents from its secondary irreversible complications. Movement Disorders 23:15, 2261-2263
CrossRef125
Constance Hammond, Rachida Ammari, Bernard Bioulac, Liliana Garcia. (2008) Latest view on the mechanism of action of deep brain stimulation. Movement Disorders 23:15, 2111-2121
CrossRef126
Andrea A. Kühn, Christof Brücke, Gerd-Helge Schneider, Thomas Trottenberg, Anatol Kivi, Andreas Kupsch, H. Holger Capelle, Joachim K. Krauss, Peter Brown. (2008) Increased beta activity in dystonia patients after drug-induced dopamine deficiency. Experimental Neurology 214:1, 140-143
CrossRef127
Michael S. Okun, Ramon L. Rodriguez, Kelly D. Foote, Atchar Sudhyadhom, Frank Bova, Charles Jacobson, Brian Bello, Pamela Zeilman, Hubert H. Fernandez. (2008) A case-based review of troubleshooting deep brain stimulator issues in movement and neuropsychiatric disorders. Parkinsonism & Related Disorders 14:7, 532-538
CrossRef128
Wataru Sako, Satoshi Goto, Hideki Shimazu, Nagako Murase, Kazuhito Matsuzaki, Tetsuya Tamura, Hideo Mure, Yusuke Tomogane, Norio Arita, Hiroo Yoshikawa, Shinji Nagahiro, Ryuji Kaji. (2008) Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia. Movement Disorders 23:13, 1929-1931
CrossRef129
Theresa E. Pretto, Arif Dalvi, Un Jung Kang, Richard D. Penn. (2008) A prospective blinded evaluation of deep brain stimulation for the treatment of secondary dystonia and primary torticollis syndromes. Journal of Neurosurgery 109:3, 405-409
CrossRef130
A. Schmidt, S. A. Schneider, J. Hagenah, C. Klein. (2008) Dystonien. Der Nervenarzt 79:S2, 53-66
CrossRef131
P. Blomstedt, S. Tisch, M. I. Hariz. (2008) Pallidal deep brain stimulation in the treatment of Meige syndrome. Acta Neurologica Scandinavica 118:3, 198-202
CrossRef132
V. K. Neychev, X. Fan, V. I. Mitev, E. J. Hess, H. A. Jinnah. (2008) The basal ganglia and cerebellum interact in the expression of dystonic movement. Brain 131:9, 2499-2509
CrossRef133
I. U. Isaias, R. L. Alterman, M. Tagliati. (2008) Outcome predictors of pallidal stimulation in patients with primary dystonia: the role of disease duration. Brain 131:7, 1895-1902
CrossRef134
John C. Morgan, Kapil D. Sethi. (2008) A single-blind trial of bilateral globus pallidus internus deep brain stimulation in medically refractory cervical dystonia. Current Neurology and Neuroscience Reports 8:4, 279-280
CrossRef135
T. J. Loher, H.-H. Capelle, A. Kaelin-Lang, S. Weber, R. Weigel, J. M. Burgunder, J. K. Krauss. (2008) Deep brain stimulation for dystonia: outcome at long-term follow-up. Journal of Neurology 255:6, 881-884
CrossRef136
Christof Brücke, Florian Kempf, A. Kupsch, Gerd-Helge Schneider, Joachim K. Krauss, Tipu Aziz, Kielan Yarrow, Alek Pogosyan, Peter Brown, Andrea A. Kühn. (2008) Movement-related synchronization of gamma activity is lateralized in patients with dystonia. European Journal of Neuroscience 27:9, 2322-2329
CrossRef137
I. M. Skogseid. (2008) Pallidal deep brain stimulation is effective, and improves quality of life in primary segmental and generalized dystonia. Acta Neurologica Scandinavica 117:s188, 51-55
CrossRef138
Jill L. Ostrem, Philip A. Starr. (2008) Treatment of dystonia with deep brain stimulation. Neurotherapeutics 5:2, 320-330
CrossRef139
Robert E. Gross. (2008) What happened to posteroventral pallidotomy for Parkinson’s disease and dystonia?. Neurotherapeutics 5:2, 281-293
CrossRef140
Clement Hamani, Elena Moro, Cindy Zadikoff, Yu-Yan Poon, Andres M. Lozano. (2008) LOCATION OF ACTIVE CONTACTS IN PATIENTS WITH PRIMARY DYSTONIA TREATED WITH GLOBUS PALLIDUS DEEP BRAIN STIMULATION. Neurosurgery 62, 217-225
CrossRef141
N. Yousif, R. Bayford, S. Wang, X. Liu. (2008) Quantifying the effects of the electrode–brain interface on the crossing electric currents in deep brain recording and stimulation. Neuroscience 152:3, 683-691
CrossRef142
Ali R. Rezai, Andre G. Machado, Milind Deogaonkar, Hooman Azmi, Cynthia Kubu, Nicholas M. Boulis. (2008) SURGERY FOR MOVEMENT DISORDERS. Neurosurgery 62:Supplement 2, SHC-809???SHC-839
CrossRef143
C. Blahak, J. C. Wöhrle, H. H. Capelle, H. Bäzner, E. Grips, R. Weigel, K. Kekelia, J. K. Krauss. (2008) Health-related quality of life in segmental dystonia is improved by bilateral pallidal stimulation. Journal of Neurology 255:2, 178-182
CrossRef144
Maria G. Cersosimo, Gabriela B. Raina, Fabian Piedimonte, Julio Antico, Pablo Graff, Federico E. Micheli. (2008) Pallidal surgery for the treatment of primary generalized dystonia: Long-term follow-up. Clinical Neurology and Neurosurgery 110:2, 145-150
CrossRef145
Stephen Tisch, John C. Rothwell, Ludvic Zrinzo, Kailash P. Bhatia, Marwan Hariz, Patricia Limousin. (2008) Cortical evoked potentials from pallidal stimulation in patients with primary generalized dystonia. Movement Disorders 23:2, 265-273
CrossRef146
X. Liu, S. Wang, J. Yianni, D. Nandi, P. G. Bain, R. Gregory, J. F. Stein, T. Z. Aziz. (2008) The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia. Brain 131:6, 1562-1573
CrossRef147
Joerg Mueller, Inger M. Skogseid, Reiner Benecke, Andreas Kupsch, Thomas Trottenberg, Werner Poewe, Gerd H. Schneider, Wilhelm Eisner, Alexander Wolters, J.U. Müller, Günther Deuschl, Marcus O. Pinsker, Geir K. Roeste, Juliane Vollmer-Haase, Angela Brentrup, Martin Krause, Volker Tronnier, Alfons Schnitzler, Jüergen Voges, Guido Nikkhah, Jan Vesper, Markus Naumann, Jens Volkmann, . (2008) Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial. Movement Disorders 23:1, 131-134
CrossRef148
Jason M. Schwalb, Clement Hamani. (2008) The history and future of deep brain stimulation. Neurotherapeutics 5:1, 3-13
CrossRef149
Daniel Harnack, Wassilios Meissner, Raik Paulat, Hannes Hilgenfeld, Wolf-Dieter Müller, Christine Winter, Rudolf Morgenstern, Andreas Kupsch. (2008) Continuous high-frequency stimulation in freely moving rats: Development of an implantable microstimulation system. Journal of Neuroscience Methods 167:2, 278-291
CrossRef150
Spiridon Papapetropoulos, Sheila Baez, Jennifer Zitser, Cenk Sengun, Carlos Singer. (2008) Retrocollis: Classification, Clinical Phenotype, Treatment Outcomes and Risk Factors. European Neurology 59:1-2, 71-75
CrossRef151
Hong Yu, Joseph S. Neimat. (2008) The treatment of movement disorders by deep brain stimulation. Neurotherapeutics 5:1, 26-36
CrossRef152
Jörg B. Schulz, . (2007) Hereditäre Bewegungsstörungen. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 50:12, 1524-1530
CrossRef153
Ludy C. Shih, Daniel Tarsy. (2007) Deep brain stimulation for the treatment of atypical parkinsonism. Movement Disorders 22:15, 2149-2155
CrossRef154
Morten L Kringelbach, Sarah LF Owen, Tipu Z Aziz. (2007) Deep-brain stimulation. Future Neurology 2:6, 633-646
CrossRef155
Jill L. Ostrem, William J. Marks, Monica M. Volz, Susan L. Heath, Philip A. Starr. (2007) Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome). Movement Disorders 22:13, 1885-1891
CrossRef156
Zelma HT Kiss. (2007) Bilateral pallidal neurostimulation—long-term motor and cognitive effects in primary generalized dystonia. Nature Clinical Practice Neurology 3:9, 482-483
CrossRef157
Erlick AC Pereira, Alexander L Green, Dipankar Nandi, Tipu Z Aziz. (2007) Deep brain stimulation: indications and evidence. Expert Review of Medical Devices 4:5, 591-603
CrossRef158
Drew S. Kern, Rajeev Kumar. (2007) Deep Brain Stimulation. The Neurologist 13:5, 237-252
CrossRef159
Nada Yousif, Xuguang Liu. (2007) Modeling the current distribution across the depth electrode–brain interface in deep brain stimulation. Expert Review of Medical Devices 4:5, 623-631
CrossRef160
Sascha Hering, Gregor K. Wenning, Klaus Seppi, Werner Poewe, Joerg Mueller. (2007) An open trial of levetiracetam for segmental and generalized dystonia. Movement Disorders 22:11, 1649-1651
CrossRef161
Ron L. Alterman, Michele Tagliati. (2007) Deep brain stimulation for torsion dystonia in children. Child's Nervous System 23:9, 1033-1040
CrossRef162
Clement Hamani, Elena Moro. (2007) Surgery for other movement disorders: dystonia, tics. Current Opinion in Neurology 20:4, 470-476
CrossRef163
Sam H. Horng, Franklin G. Miller. (2007) Placebo-controlled procedural trials for neurological conditions. Neurotherapeutics 4:3, 531-536
CrossRef164
S. Tisch, J.C. Rothwell, P. Limousin, M.I. Hariz, D.M. Corcos. (2007) The Physiological Effects of Pallidal Deep Brain Stimulation in Dystonia. IEEE Transactions on Neural Systems and Rehabilitation Engineering 15:2, 166-172
CrossRef165
Daniel Tarsy. (2007) Deep-brain stimulation for dystonia: new twists in assessment. The Lancet Neurology 6:3, 201-202
CrossRef166
Marie Vidailhet, Laurent Vercueil, Jean-Luc Houeto, Pierre Krystkowiak, Christelle Lagrange, Jerôme Yelnik, Eric Bardinet, Alim-Louis Benabid, Soledad Navarro, Didier Dormont, Sylvie Grand, Serge Blond, Claire Ardouin, Bernard Pillon, Katy Dujardin, Valérie Hahn-Barma, Yves Agid, Alain Destée, Pierre Pollak. (2007) Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: a prospective 3 year follow-up study. The Lancet Neurology 6:3, 223-229
CrossRef167
Norra MacReady. (2007) Noteworthy Advances in Movement Disorders. Neurology Today 7:4, 4-5
CrossRef168
John Rothwell. (2007) Transcranial magnetic stimulation as a method for investigating the plasticity of the brain in Parkinson's Disease and dystonia. Parkinsonism & Related Disorders 13, S417-S420
CrossRef169
Elizabeth Stump. (2006) DNA Screening Program Launched for Women. Neurology Today 6:23, 17-18
CrossRef170
Kurt Samson. (2006) SHAM STIMULATION TRIAL SHOWS MAJOR GAINS IN PRIMARY DYSTONIA PATIENTS RECEIVING DBS. Neurology Today 6:23, 12-13
CrossRef
