Original Article
Efficacy of an Acellular Pertussis Vaccine among Adolescents and Adults
N Engl J Med 2005; 353:1555-1563October 13, 2005
- Abstract
Background
Pertussis immunization of adults may be necessary to improve the control of a rising burden of disease and infection. This trial of an acellular pertussis vaccine among adolescents and adults evaluated the incidence of pertussis, vaccine safety, immunogenicity, and protective efficacy.
Methods
Bordetella pertussis infections and illnesses were prospectively assessed in 2781 healthy subjects between the ages of 15 and 65 years who were enrolled in a national multicenter, randomized, double-blind trial of an acellular pertussis vaccine. Subjects received either a dose of a tricomponent acellular pertussis vaccine or a hepatitis A vaccine (control) and were monitored for 2.5 years for illnesses with cough that lasted for more than 5 days. Each illness was evaluated with use of a nasopharyngeal aspirate for culture and polymerase-chain-reaction assay, and serum samples from patients in both acute and convalescent stages of illness were analyzed for changes in antibodies to nine B. pertussis antigens.
Results
Of the 2781 subjects, 1391 received the acellular pertussis vaccine and 1390 received the control vaccine. The groups had similar ages and demographic characteristics, and the median duration of follow-up was 22 months. The acellular pertussis vaccine was safe and immunogenic. There were 2672 prolonged illnesses with cough, but the incidence of this nonspecific outcome did not vary between the groups, even when stratified according to age, season, and duration of cough. On the basis of the primary pertussis case definition, vaccine protection was 92 percent (95 percent confidence interval, 32 to 99 percent). Among unimmunized controls with illness, 0.7 percent to 5.7 percent had B. pertussis infection, and the percentage increased with the duration of cough. On the basis of other case definitions, the incidence of pertussis in the controls ranged from 370 to 450 cases per 100,000 person-years.
Conclusions
The acellular pertussis vaccine was protective among adolescents and adults, and its routine use might reduce the overall disease burden and transmission to children.
Media in This Article
Table 1
Summary of Pertussis Case Definitions.Table 2
Characteristics of Subjects in the Acellular Pertussis and Control Groups.Article Activity
- Article
Bordetella pertussis infects the human respiratory tract and in nonimmune persons causes whooping cough, a severe illness associated with prolonged cough.1,2 The severity of illness varies with age, immune status (prior immunization or infection), and probably such factors as the extent of exposure and the virulence of the organism. Disease risk and severity are greatest in unimmunized infants.3-5 During the past 50 years, routine pediatric pertussis immunization has dramatically decreased the pediatric disease burden.1,2 In the United States, the annual incidence of pertussis fell from 157 per 100,000 persons in the prevaccine era to less than 1 per 100,000 persons; mortality was even more dramatically reduced.6 Nonetheless, pediatric immunization has not decreased the incidence of disease in older persons or the occurrence of outbreaks, nor has it eliminated the transmission of infections to unimmunized children.
Infections among adolescents and adults result from waning immunity, since immunization or infection does not induce long-lived immunity. Infections can be asymptomatic, mildly symptomatic, or classic in presentation.1 Pertussis vaccines have not been recommended for persons older than six years of age; consequently, pertussis continues to circulate among older persons, which creates a source of contagion for young children.7-13 During the 1990s, both the number and the proportion of reported pertussis cases among adolescents and adults more than doubled in the United States and Canada.5,14 Most adult cases are not suspected, detected, or reported, and the possibility of a case of pertussis is usually considered only when it occurs in association with classic whooping cough in children.1,7-10,13 Many factors contribute to the failure to detect pertussis, including the lack of clinical awareness, the lack of availability and insensitivity of culture and polymerase-chain-reaction (PCR) assay, a lack of standardized serologic testing for pertussis, the difficulty of obtaining appropriate specimens, and the absence of clear serologic diagnostic criteria.
Component vaccines that combine diphtheria and tetanus toxoids with acellular pertussis are safe and effective in children and are routinely used worldwide.1,2 The safety and immunogenicity of several acellular pertussis vaccines have been evaluated in formulations with diphtheria and tetanus toxoids and have been shown to be safe and immunogenic.14-17 The adult vaccines have lower concentrations of acellular pertussis and diphtheria toxoids than do the pediatric vaccines, and two of these preparations have recently been licensed in the United States (www.fda.gov/cber).
The objectives of the Adult Pertussis Trial (APERT), which was sponsored by the National Institutes of Health (NIH), were to ascertain among adolescents and adults the clinical spectrum, incidence, and epidemiology of infection and disease, assess the safety of the acellular pertussis vaccine, characterize both natural and vaccine-induced immune responses, and (with the use of multiple outcome measures) assess the protective efficacy of an acellular pertussis vaccine. In this article, we focus on protective efficacy.
Methods
Study Population
Between July 1997 and December 1999, 2781 healthy subjects between the ages of 15 and 65 years were recruited at eight participating U.S. sites: Baylor College of Medicine, Houston; Cincinnati Children's Hospital, Cincinnati; Saint Louis University, St. Louis; the University of Maryland, Baltimore and College Park; the University of Rochester, Rochester, New York; Vanderbilt University, Nashville; the University of Pittsburgh, Pittsburgh; and the UCLA Center for Vaccine Research at Harbor–UCLA Medical Center, Torrance, California.
Subjects were ineligible if they had participated in other clinical trials, were immunocompromised, had chronic disease, had received pertussis vaccine within the previous five years, had received immune globulin therapy or blood products within the previous three months, had vaccine hypersensitivity, had received erythromycin or a related antibiotic recently, or had been diagnosed with pertussis within the previous five years. Women of childbearing age were tested for pregnancy and were required to use birth control for the month after vaccination.
Study Design
This randomized, multicenter, double-blind, parallel-group, controlled trial was designed to evaluate subjects who had received a single intramuscular dose of either an acellular pertussis vaccine or a hepatitis A vaccine (control). Written informed consent was obtained from all participants. After recruitment and immunization, subjects were followed for up to 2.5 years with twice-monthly phone calls to ascertain all illnesses with cough. There were five scheduled visits for blood sampling in addition to paired visits during acute illness and convalescence to obtain microbiologic and serologic evaluations for each illness lasting more than five days. All subject-months of observation were included; 94 percent of the subjects completed 12 to 17 months of follow-up, and 80 percent completed 18 to 24 months.
Vaccines and Blinding
Vaccines were manufactured by GlaxoSmithKline Biologicals. Each 0.5-ml dose of the three-component acellular pertussis vaccine (without diphtheria or tetanus toxoid) contained 8 μg of toxoided pertussis toxin, 8 μg of filamentous hemagglutinin, and 2.5 μg of pertactin — a dose whose pertussis-antigen content was approximately one third that of the acellular pertussis vaccine for children (Infanrix, GlaxoSmithKline). The hepatitis A vaccine (Havrix) contained hepatitis A virus (strain HM 175, 720 enzyme-linked immunosorbent assay [ELISA] units). The vaccines were visually indistinguishable and identically packaged and were administered intramuscularly with the use of standard techniques.
Safety Assessments
Each subject was observed for 30 minutes after vaccination. Diary cards were used to record temperature and local or systemic adverse events for 14 days after vaccination. Telephone calls were also made, and purported reactions were referred for evaluation. Late reactions were assessed at the one-month and one-year follow-up visits. Serious adverse events and pregnancies were monitored for the entire study period. A safety monitor and a data monitoring and safety committee provided ongoing study oversight.
Detection of Illness and Microbiologic Assessment
All illnesses with cough of a duration of five days or more were ascertained by telephone surveillance every other week during the trial and by self-reporting by subjects. Each episode was evaluated clinically, serologically, and microbiologically (nasopharyngeal aspirate for culture and PCR assay by a method modified from Hallander et al.18). Cultures were processed as previously described,19 and throughout the trial, blinded evaluations of proficiency culture testing were conducted at each study site to validate results. PCR analysis was carried out at a centralized laboratory (UCLA Clinical Laboratory) with the use of primers PTp1 and PTp2 with methods previously described.20-22 The sensitivity of the assay was from 10 to 100 organisms per milliliter, and specificity and sensitivity were evaluated with the use of blinded controls, as well as with primers for β globin.23
Serologic Assessments
In all study subjects, blood specimens for antibody assays were obtained before immunization and one month and one year after vaccination. To assess decay of antibody to acellular pertussis antigens after vaccination, additional blood samples were obtained from the first 10 percent of subjects who were enrolled at each study site 6 and 18 months after vaccination.24 In addition, for each episode of prolonged illness with cough, an acute-phase specimen was collected 5 to 14 days after the onset of cough, and a convalescent-phase specimen was obtained 21 to 45 days after the onset. Serum samples were stored at –70°C until the assays could be performed in a blinded manner in a central laboratory with the use of standardized procedures validated by the Food and Drug Administration (FDA). ELISA serologic assays were performed for IgG and IgA antibodies to pertussis toxin, filamentous hemagglutinin, pertactin, and fimbriae (types 2 and 3), as well as by microagglutination assay with the use of B. pertussis strain B 460.12,24-28 The sensitivity, reproducibility, and specificity were carefully assessed for each assay, and the lower limit of quantitation was used as the lower limit for assessment of the increases in titer in paired serum samples that were run in the same microtiter plates.24
Pertussis Case Definitions
The primary pertussis case definition was established before the trial began and required the presence of illness with cough lasting 5 days or more that was clinically, microbiologically, and serologically evaluated within 14 days after onset and that occurred more than 28 days after vaccination. Confirmation required a positive culture, PCR analysis, or stringent serologic evidence of B. pertussis infection (an increase in the titer of antibody to pertussis toxin by a factor of two or more or a similar response to two other pertussis antigens). The primary and secondary case definitions are specified in Table 1Table 1
Summary of Pertussis Case Definitions..Statistical Analysis
All patient-months of observation and prolonged (>5 day) episodes of illness with cough are included in rate analyses. Approximately 25 percent of subjects had more than a single prolonged illness with cough (50 percent had none), but none had evidence of B. pertussis infection more than once during the trial. The comparisons of baseline characteristics between vaccine groups were performed with use of the chi-square test for categorical variables and t-test for numeric variables. The comparisons of outcomes of illness with cough between the two groups were performed with use of a two-tailed Fisher's exact test. Vaccine efficacy was calculated (as a percentage) as follows: (1 – IR) × 100, where IR is the case incidence-rate ratio between the group that received acellular pertussis vaccine and the group that received hepatitis A vaccine. The estimate of vaccine efficacy was further adjusted for the duration of illness by means of multivariable Poisson regression analysis. This estimate was calculated with the use of a time-homogeneous Poisson model, and the 95 percent confidence interval was constructed with the use of the method for exact Poisson distribution available in LogXact 5 software.
Results
A total of 1391 subjects were randomly assigned to receive the acellular pertussis vaccine, and 1390 subjects to receive the hepatitis A vaccine (controls). Subjects ranged in age from 15 to 65 years (average, 34.8) and included health care workers (32 percent), students (21 percent), and community volunteers (47 percent). Sixty-seven percent of the subjects were female; 71 percent were white. Demographic characteristics of the subjects in the two study groups were similar, and there was no meaningful difference in follow-up (Table 2Table 2
Characteristics of Subjects in the Acellular Pertussis and Control Groups., and Table 1 of the Supplementary Appendix, available with the full text of this article at www.nejm.org). The groups were similar in the types of preexisting medical conditions, history of smoking, and the age of household contacts; there were no recognized outbreaks or clusters of pertussis during the two-year study period. A total of 547 subjects withdrew during the trial, but most of these withdrawals occurred during the final six months of a trial extension period. All patient-months of follow-up were included in the analyses. The median duration of follow-up for all subjects was 22 months, with no difference between the groups.Vaccine Safety
A total of 165 serious adverse events, as defined by established FDA criteria, occurred in 140 subjects, including 5 deaths, 14 cases of cancer, 1 emergency room visit, and 145 hospitalizations. A total of 86 serious adverse events occurred among 69 subjects in the acellular pertussis group and 79 among the 71 control subjects. Four hospitalizations (two in each group) occurred within 14 days after immunization. None of the serious adverse events were deemed by the data monitoring and safety committee to be vaccine-related. Sixty pregnancies were reported during the trial (10 within two months after vaccination); none were associated with neonatal abnormalities.
All Illnesses with Cough
A total of 2672 illnesses with cough that lasted five days or more were evaluated, yielding an average incidence of prolonged illness with cough of 0.63 episode per subject-year. Approximately half the subjects had no prolonged episodes of illness with cough, but 24 percent had two or more episodes. The mean duration of illness was 24 days (median, 18); 66 percent of the illnesses lasted more than 15 days, and 46 percent lasted more than 20 days. The peak seasonal incidence occurred between December and March, and there was little difference according to age. There was no significant difference in the incidence of prolonged illness between patients who received the acellular pertussis vaccine and controls, even after stratification according to season, age, study site, and duration of cough.
Primary Pertussis Cases
As shown in Table 3Table 3
Summary of Pertussis Cases Meeting the Primary Case Definition., there were 10 cases of pertussis that met the primary case definition; 4 of the cases were culture-positive, and 5 were PCR-positive. All the cases met the primary serologic case criteria. The five B. pertussis isolates were analyzed by pulsed-field gel electrophoresis at the Centers for Disease Control and Prevention, and all isolates were clonally different. Two potential cases were ruled out by the data monitoring and safety committee after blinded consideration. One subject, whose illness was not included as a case, had a positive culture for B. bronchiseptica and a negative test for B. pertussis on PCR assay and serologic analysis. The other excluded case involved 16 days of illness with cough and a positive B. pertussis culture but a negative PCR assay (which was repeated blindly three times), and all serologic analyses were negative. The subject also had a consistent decline in all B. pertussis antibodies as assessed in 10 sequential serologic specimens over a period of two years. Although the isolate from this subject was confirmed to be B. pertussis, it was probably a laboratory contaminant, since other B. pertussis cultures were in the incubator at the same time. There was one vaccine failure (in Subject 10), with clinical illness indistinguishable from that in the controls, and this episode was confirmed by serologic analysis alone.There were few distinguishing epidemiologic or clinical characteristics among the 10 primary cases and the other prolonged illnesses with cough of undefined cause. The pertussis cases tended to be in younger subjects (P=0.027), and the duration of cough was significantly greater than in subjects who had an illness with cough from other causes (P<0.001). Fever was significantly less common among those with pertussis than among others with a prolonged illness with cough (P=0.047). There were no significant differences in the rate of coryza, malaise, sore throat, chest congestion, chest pain, productive cough, or difficulty in breathing between the subjects with primary pertussis and those with prolonged illness with cough of undefined cause.
Vaccine Efficacy
As shown in Table 4Table 4
Vaccine Efficacy with Use of Various Case Definitions., nine cases of pertussis in the control group and one in the acellular pertussis vaccine group met the primary case definition, yielding an overall vaccine efficacy of 92 percent (95 percent confidence interval, 32 to 99 percent) when adjusted for the duration of illness and 89 percent (95 percent confidence interval, 19 to 99 percent) when unadjusted for the duration of illness. Among cases that were confirmed by culture or PCR assay, five were in the control group and none were in the acellular pertussis vaccine group. When less stringent and less specific serologic secondary case definitions were employed, there was a trend toward lower vaccine efficacy. No additional cases were identified when a serum sample obtained before illness was evaluated (with serologic analysis performed within six months after the onset of illness) relative to the convalescent-phase sample. This was a secondary case definition for 681 subjects with such serum samples available, and it was thought to be more sensitive for the detection of early antibody increases (before the acute-illness specimen was obtained).Estimate of Disease Incidence
The incidence of pertussis is best assessed in the unimmunized control group. For the primary case definition, there were nine cases per 2444 persons during two years of observation, which yielded 370 cases per 100,000 person-years. When various pertussis case definitions were used (Table 1), the incidence among controls was estimated to be 370 to 450 cases per 100,000 persons per year.
Proportion of Prolonged Illnesses Due to B. Pertussis Infection
In Table 5Table 5
Incidence of Cases of Confirmed Pertussis According to the Duration of Illness with Cough., the proportion of subjects meeting the primary case definition of pertussis in each study group is stratified according to duration of illness. Among the controls who had illnesses with cough of a duration of five days or more, 0.7 percent had evidence of B. pertussis infection. If illnesses of longer duration are considered, the proportion of subjects with B. pertussis infection increases sequentially to 5.7 percent for illnesses lasting more than 56 days. This finding is also shown in the adjusted values for efficacy in Table 4, since there is a higher vaccine efficacy in the prevention of pertussis when the analysis accounts for the duration of illness with cough.Discussion
Illness with cough that is prolonged (five days or more) is common and is associated with substantial morbidity and health care costs. During this trial, 63 percent of subjects had a prolonged illness with cough each year, with an average duration of 24.4 days. Such illnesses can have many causes, but we found that B. pertussis accounted for 0.7 to 5.7 percent of the episodes, depending on the duration of cough. Risk factors for pertussis included adolescent age, an absence of fever, and a prolonged duration of cough. Immunization with the acellular pertussis vaccine prevented pertussis but did not decrease the overall burden of prolonged illnesses with cough, because pertussis constituted only a small proportion of these illnesses.
In adolescents and adults, it is difficult to establish the diagnosis of pertussis. Consequently, pertussis in older persons is rarely suspected, detected, reported, or well studied, and the disease burden is underappreciated. Furthermore, since older persons are partially immune from previous immunizations and natural infections, it is difficult to distinguish infections by serologic analysis without carefully assessing changes in antibody levels (changes in titer between the acute and convalescent phases). Some antibody levels wane quickly (especially pertussis toxin), and other antibodies lack specificity for pertussis (especially pertactin and filamentous hemagglutinin).13,24,25,29
In this study, prospective data obtained from unimmunized controls over a period of 2.5 years are particularly useful to assess the incidence of pertussis in older age groups. On the basis of the primary case definition, the overall annual incidence was 370 cases of pertussis per 100,000 persons between the ages of 15 and 65 years. This rate is similar to that measured in another active surveillance study.30 If these rates are extrapolated to the total U.S. population, almost a million pertussis cases per year occur in the United States in persons 15 years of age and older. This does not include asymptomatic or mildly symptomatic infections or infections that are identified with less specific diagnostic criteria.31 Data from this study that are not presented here showed that the number of asymptomatic patients (those with seroconversion) exceeded the number of symptomatic patients by a factor of 5 to 10. A high proportion of the disease burden is potentially preventable by vaccination, which might reduce community transmission.
Since immunity to pertussis wanes, the disease continues to occur in adolescents and adults in spite of high levels of administration of acellular pertussis vaccine in children.24,31,32 Therefore, the control of pertussis will probably require immunization of all adolescents and adults in addition to children. Two acellular pertussis vaccines formulated for adolescents and adults have recently been licensed.33 Although the vaccines differ slightly in formulation, they are thought to have equivalent safety, immunogenicity, and protective efficacy. Both of these vaccines have one third the concentration of pertussis toxin that is found in the pediatric formulation; with a single dose, both vaccines induce an antibody response to B. pertussis antigens that is significantly greater in adults than that observed in infants at seven months of age after three doses of the two manufacturers' pediatric vaccines. Such data suggest that both of the newly licensed acellular pertussis vaccines will be efficacious among adolescents and adults. In this trial, the efficacy of a single dose of acellular pertussis vaccine among adolescents and adults (92 percent) supports this conclusion, because pertussis antigen components of the monovalent vaccine that was used in this trial are identical to the acellular pertussis components in one recently licensed vaccine (Boostrix, GlaxoSmithKline) and are similar to those in the other acellular pertussis vaccine (Adacel, Sanofi Pasteur). The duration of protection and prevention of secondary disease were not assessed.
Pertussis is one of the least well controlled illnesses that are preventable by vaccine, and optimal control will probably require routine immunization of adolescents and adults to reduce disease burden and transmission.31 Older persons serve as a reservoir of infection for young children, who have greater morbidity than adults.7-10 Several strategies for the delivery of acellular pertussis vaccines to adolescents and adults have been evaluated,34,35 including the routine immunization of all adolescents and adults, targeted immunizations of special groups, and the use of vaccine during outbreaks. The immunization of adolescents between the ages of 10 and 19 years may be the most cost-beneficial initial strategy in view of the ease and cost of implementation. Our data provide additional support for the use of acellular pertussis vaccines among adolescents and adults for the enhanced control of pertussis.
Supported by the NIH's Division of Microbiology and Infectious Diseases and the National Institute of Allergy and Infectious Diseases (grant no. N01-AI-45249) under a cooperative research and development agreement with GlaxoSmithKline. None of the authors have a financial interest in the vaccine or the manufacturer.
Dr. Bernstein reports having received grant support from GlaxoSmithKline and Sanofi Pasteur and royalties related to a rotavirus vaccine licensed to GlaxoSmithKline. Dr. Cherry and Dr. Edwards report having received consultation and lecture fees from GlaxoSmithKline and Sanofi Pasteur and grant support from Sanofi Pasteur. Dr. Greenberg reports having received consultation and lecture fees from GlaxoSmithKline and Sanofi Pasteur, and is currently an employee of Sanofi Pasteur. Dr. Ward reports having received lecture fees and grant support from GlaxoSmithKline.
Source Information
From the UCLA Center for Vaccine Research, Research and Education Institute, Harbor–UCLA Medical Center, David Geffen School of Medicine, UCLA, Torrance, Calif. (J.I.W., J.D.C., S.-J.C., S.P., H.L.); University of Rochester, Rochester, N.Y. (J.T.); University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh (D.P.G.); Baylor College of Medicine, Houston (W.K.); Saint Louis University, St. Louis (S.B.); Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati (D.I.B.); Department of Medicine and the Center for Vaccine Development, University of Maryland School of Medicine, Baltimore (R.E.); and the Pediatric Clinical Research Office, Vanderbilt University Medical Center, Nashville (K.E.).
Address reprint requests to Dr. Ward at the UCLA Center for Vaccine Research, LA Biomed, Harbor–UCLA Medical Center, David Geffen School of Medicine, UCLA, Torrance, CA 90502.
Other participants in the Adult Pertussis Trial (APERT) are listed in the Appendix.
Appendix
The following persons supported and contributed to the APERT trial: members of the data monitoring and safety committee — N. Halsey (chair), S. Halperin, W. Schaffner, J. Elashoff, M. Deloria, and E. Hewlett; investigators — R. Rabinovich, M. Decker, M. Pichichero, and D. Klein; data-management personnel — J. Jing, J. Alvarado, P. Madrigal, and J. Straube; research coordinators — P. Chatfield, C. Rangel, N. Bond, A. Jenkins, R. Barnes, K. Yeager, H. Secrest, K. Smail, C. Bimlee, K. Geldmacher, C. Stefanski, D. O'Brien, J. Harris, S. Foster, and L. Willis; and laboratory personnel — T. Patel, E. Pineda, A. Garakian, and M. Miller.
- References
References
1
Cherry JD, Heininger U. Pertussis and other Bordetella infections. In: Feigin RD, Cherry JD, Demmler GJ, Kaplan S, eds. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: W.B. Saunders, 2004:1588-608.
2
Edwards KM, Decker MD. Pertussis vaccine. In: Plotkin SA, Orenstein WA, eds. Vaccines. 4th ed. Philadelphia: W.B. Saunders, 2004:471-528.
3
Tanaka M ,Vitek CR ,Pascual FB ,Bisgard KM ,Tate JE ,Murphy TV . Trends in pertussis among infants in the United States, 1980-1999. JAMA 2003;290:2968-2975
CrossRef | Web of Science | Medline4
Vitek CR ,Pascual FB ,Baughman AL ,Murphy TV . Increase in deaths from pertussis among young infants in the United States in the 1990s. Pediatr Infect Dis J 2003;22:628-634
CrossRef | Web of Science | Medline5
Pertussis -- United States, 1997-2000. MMWR Morb Mortal Wkly Rep 2002;51:73-76
Medline6
Cherry JD . The epidemiology of pertussis and pertussis immunization in the United Kingdom and the United States: a comparative study. Curr Probl Pediatr 1984;14:1-78
CrossRef | Medline7
Deen JL ,Mink CA ,Cherry JD , et al. Household contact study of Bordetella pertussis infections. Clin Infect Dis 1995;21:1211-1219
CrossRef | Web of Science | Medline8
Bisgard KM ,Pascual FB ,Ehresmann KR , et al. Infant pertussis: who was the source? Pediatr Infect Dis J 2004;23:985-989
CrossRef | Web of Science | Medline9
Crowcroft NS ,Booy R ,Harrison T , et al. Severe and unrecognised: pertussis in UK infants. Arch Dis Child 2003;88:802-806
CrossRef | Web of Science | Medline10
Baron S ,Njamkepo E ,Grimprel E , et al. Epidemiology of pertussis in French hospitals in 1993 and 1994: thirty years after a routine use of vaccination. Pediatr Infect Dis J 1998;17:412-418
CrossRef | Web of Science | Medline11
Pertussis. In: Pickering L, ed. Red book: 2003 report of the Committee on Infectious Diseases. Elk Grove Village, Ill.: American Academy of Pediatrics, 2003:472.
12
Mink CM ,Cherry JD ,Christenson P , et al. A search for Bordetella pertussis infection in university students. Clin Infect Dis 1992;14:464-471
CrossRef | Web of Science | Medline13
Cherry JD . Epidemiological, clinical, and laboratory aspects of pertussis in adults. Clin Infect Dis 1999;28:Suppl 2:S112-S117
CrossRef | Web of Science | Medline14
Keitel WA ,Muenz LR ,Decker MD , et al. A randomized clinical trial of acellular pertussis vaccines in healthy adults: dose-response comparisons of 5 vaccines and implications for booster immunization. J Infect Dis 1999;180:397-403
CrossRef | Web of Science | Medline15
Pichichero ME, Blatter MM, Kennedy WA, et al. Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents. Pediatrics (in press).
16
Van der Wielen M ,Van Damme P ,Joossens E ,Francois G ,Meurice F ,Ramalho A . A randomised controlled trial with a diphtheria-tetanus-acellular pertussis (dTpa) vaccine in adults. Vaccine 2000;18:2075-2082
CrossRef | Web of Science | Medline17
Southern J ,Andrews N ,Burrage M ,Miller E . Immunogenicity and reactogenicity of combined acellular pertussis/tetanus/low dose diphtheria vaccines given as a booster to UK teenagers. Vaccine 2005;23:3829-3835
CrossRef | Web of Science | Medline18
Hallander HO ,Reizenstein E ,Renemar B ,Rasmuson G ,Mardin L ,Olin P . Comparison of nasopharyngeal aspirates with swabs for culture of Bordetella pertussis. J Clin Microbiol 1993;31:50-52
Web of Science | Medline19
Heininger U ,Cherry JD ,Eckhardt T ,Lorenz C ,Christenson P ,Stehr K . Clinical and laboratory diagnosis of pertussis in the regions of a large vaccine efficacy trial in Germany. Pediatr Infect Dis J 1993;12:504-509
CrossRef | Web of Science | Medline20
Schlapfer G ,Cherry JD ,Heininger U , et al. Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis vaccine efficacy trial in Germany. Pediatr Infect Dis J 1995;14:209-214
CrossRef | Web of Science | Medline21
Houard S ,Hackel C ,Herzog A ,Bollen A . Specific identification of Bordetella pertussis by the polymerase chain reaction. Res Microbiol 1989;140:477-487
CrossRef | Web of Science | Medline22
Nelson S ,Matlow A ,McDowell C , et al. Detection of Bordetella pertussis in clinical specimens by PCR and a microtiter plate-based DNA hybridization assay. J Clin Microbiol 1997;35:117-120
Web of Science | Medline23
Bauer HM ,Ting Y ,Greer CE , et al. Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA 1991;265:472-477
CrossRef | Web of Science | Medline24
Le T ,Cherry JD ,Chang SJ , et al. Immune responses and antibody decay after immunization of adolescents and adults with an acellular pertussis vaccine: the APERT Study. J Infect Dis 2004;190:535-544
CrossRef | Web of Science | Medline25
Hodder SL ,Cherry JD ,Mortimer EA Jr ,Ford AB ,Gornbein J ,Papp K . Antibody responses to Bordetella pertussis antigens and clinical correlations in elderly community residents. Clin Infect Dis 2000;31:7-14
CrossRef | Web of Science | Medline26
Cherry JD ,Beer T ,Chartrand SA , et al. Comparison of values of antibody to Bordetella pertussis antigens in young German and American men. Clin Infect Dis 1995;20:1271-1274
CrossRef | Web of Science | Medline27
Manclark CR, Meade BD, Burstyn DG. Serological response to Bordetella pertussis. In: Rose NR, Friedman H, Fahey JL, eds. Manual of clinical laboratory immunology. 3rd ed. Washington, D.C.: American Society for Microbiology, 1986:388-94.
28
Cherry JD ,Chang SJ ,Klein D , et al. Prevalence of antibody to Bordetella pertussis antigens in serum specimens obtained from 1793 adolescents and adults. Clin Infect Dis 2004;39:1715-1718
CrossRef | Web of Science | Medline29
Vincent JM ,Cherry JD ,Nauschuetz WF , et al. Prolonged afebrile nonproductive cough illnesses in American soldiers in Korea: a serological search for causation. Clin Infect Dis 2000;30:534-539
CrossRef | Web of Science | Medline30
Strebel P ,Nordin J ,Edwards K , et al. Population-based incidence of pertussis among adolescents and adults, Minnesota, 1995-1996. J Infect Dis 2001;183:1353-1359
CrossRef | Web of Science | Medline31
Cherry JD . The epidemiology of pertussis: a comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection. Pediatrics 2005;115:1422-1427
CrossRef | Web of Science | Medline32
Heininger U ,Cherry JD ,Stehr K . Serologic response and antibody-titer decay in adults with pertussis. Clin Infect Dis 2004;38:591-594
CrossRef | Web of Science | Medline33
Cherry JD . Pertussis vaccines for adolescents and adults. Pediatrics 2005;116:755-756
CrossRef | Web of Science | Medline34
Purdy KW ,Hay JW ,Botteman MF ,Ward JI . Evaluation of strategies for use of acellular pertussis vaccine in adolescents and adults: a cost-benefit analysis. Clin Infect Dis 2004;39:20-28
CrossRef | Web of Science | Medline35
Van Rie A ,Hethcote HW . Adolescent and adult pertussis vaccination: computer simulations of five new strategies. Vaccine 2004;22:3154-3165
CrossRef | Web of Science | Medline
- Citing Articles (91)
Citing Articles
1
W. P. Goins, K. M. Edwards, C. L. Vnencak-Jones, M. T. Rock, M. Swift, V. Thayer, W. Schaffner, T. R. Talbot. (2012) A Comparison of 2 Strategies to Prevent Infection Following Pertussis Exposure in Vaccinated Healthcare Personnel. Clinical Infectious Diseases
CrossRef2
D. M. Skowronski, N. Z. Janjua, E. P. Sonfack Tsafack, M. Ouakki, L. Hoang, G. De Serres. (2011) The Number Needed to Vaccinate to Prevent Infant Pertussis Hospitalization and Death Through Parent Cocoon Immunization. Clinical Infectious Diseases
CrossRef3
David E. Hiebeler, Isaac J. Michaud, Hamilton Hoxie Ackerman, Shannon Reed Iosevich, Andre Robinson. (2011) Multigeneration Reproduction Ratios and the Effects of Clustered Unvaccinated Individuals on Epidemic Outbreak. Bulletin of Mathematical Biology 73:12, 3047-3070
CrossRef4
M. H. ROZENBAUM, R. De VRIES, H. H. LE, M. J. POSTMA. (2011) Modelling the impact of extended vaccination strategies on the epidemiology of pertussis. Epidemiology and Infection1-12
CrossRef5
Scott A. Halperin, David Scheifele, Gaston De Serres, Francisco Noya, William Meekison, Paul Zickler, Luc Larrivée, Joanne M. Langley, Shelly A. McNeil, Simon Dobson, Emilia Jordanov, Manoj Thakur, Michael D. Decker, David R. Johnson. (2011) Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose. Vaccine
CrossRef6
Pierre Van Damme, Peter McIntyre, Emmanuel Grimprel, Sherine Kuriyakose, Jeanne-Marie Jacquet, Karin Hardt, Marc Messier, Olivier Van Der Meeren. (2011) Immunogenicity of the reduced-antigen-content dTpa vaccine (Boostrix®) in adults 55 years of age and over: A sub-analysis of four trials. Vaccine 29:35, 5932-5939
CrossRef7
Qi Zhang, Fulian Han, Qing Nie, Hongyu Ren, Baoqiang Zhang, Qiyong Liu, Qiushui He, Zhujun Shao. (2011) Seroprevalence of antibodies to pertussis and diphtheria among healthy adults in China. Journal of Infection
CrossRef8
Jon Smith, Marc Lipsitch, Jeffrey W Almond. (2011) Vaccine production, distribution, access, and uptake. The Lancet 378:9789, 428-438
CrossRef9
Fred Zepp, Ulrich Heininger, Jussi Mertsola, Ewa Bernatowska, Nicole Guiso, John Roord, Alberto E Tozzi, Pierre Van Damme. (2011) Rationale for pertussis booster vaccination throughout life in Europe. The Lancet Infectious Diseases 11:7, 557-570
CrossRef10
J. A. Grogan, C. Logan, J. O'Leary, R. Rush, N. O'Sullivan. (2011) Real-time PCR-based detection of Bordetella pertussis and Bordetella parapertussis in an Irish paediatric population. Journal of Medical Microbiology 60:6, 722-729
CrossRef11
Inma Crespo, Neus Cardeñosa, Pere Godoy, Gloria Carmona, M. Rosa Sala, Irene Barrabeig, Josep Álvarez, Sofia Minguel, Neus Camps, Joan Caylà, Joan Batalla, Gemma Codina, Ángela Domínguez. (2011) Epidemiology of pertussis in a country with high vaccination coverage. Vaccine 29:25, 4244-4248
CrossRef12
Rachel L. Zastrow. (2011) Emerging Infections: Pertussis on the Rise. AJN, American Journal of Nursing 111:6, 51-56
CrossRef13
Kay Wang, Anthony Harnden. (2011) Pertussis-induced cough. Pulmonary Pharmacology & Therapeutics 24:3, 304-307
CrossRef14
Tae Hyong Kim, Jennie Johnstone, Mark Loeb. (2011) Vaccine herd effect. Scandinavian Journal of Infectious Diseases1-7
CrossRef15
Amir Rouhani. (2011) Commentary. Annals of Emergency Medicine 57:5, 508-509
CrossRef16
Brady L. Miller, Katrina Kretsinger, Gary L. Euler, Peng-Jun Lu, Faruque Ahmed. (2011) Barriers to early uptake of tetanus, diphtheria and acellular pertussis vaccine (Tdap) among adults—United States, 2005–2007. Vaccine 29:22, 3850-3856
CrossRef17
Paul F. Walsh, Lauren Kimmel, Melanie Feola, Ty Tran, Christina Lim, Lisa De Salvia, James Pusavat, Scott Michaelson, Tuan Anh Nguyen, Kirt Emery, Eli Mordechai, Martin E. Adelson. (2011) Prevalence of Bordetella pertussis and Bordetella parapertussis in Infants Presenting to the Emergency Department with Bronchiolitis. The Journal of Emergency Medicine 40:3, 256-261
CrossRef18
Carl Llor, Ana Moragas, Carolina Bayona, Rosa Morros, Helena Pera, Josep M Cots, Yvonne Fernández, Marc Miravitlles, Albert Boada. (2011) Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol. BMC Pulmonary Medicine 11:1, 38
CrossRef19
David N Fisman, Patrick Tang, Tanya Hauck, Susan Richardson, Steven J Drews, Donald E Low, Frances Jamieson. (2011) Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modeling. BMC Public Health 11:1, 694
CrossRef20
Elizabeth A. Talbot, Kristin H. Brown, Kathryn B. Kirkland, Andrew L. Baughman, Scott A. Halperin, Karen R. Broder. (2010) The safety of immunizing with tetanus–diphtheria–acellular pertussis vaccine (Tdap) less than 2 years following previous tetanus vaccination: Experience during a mass vaccination campaign of healthcare personnel during a respiratory illness outbreak. Vaccine 28:50, 8001-8007
CrossRef21
Kenji Okada, Takako Komiya, Akihiko Yamamoto, Motohide Takahashi, Kazunari Kamachi, Takashi Nakano, Takao Nagai, Nobuhiko Okabe, Hitoshi Kamiya, Tetsuo Nakayama. (2010) Safe and effective booster immunization using DTaP in teenagers. Vaccine 28:48, 7626-7633
CrossRef22
Tjalke A. Westra, Robin de Vries, Johannes J. Tamminga, Christophe J. Sauboin, Maarten J. Postma. (2010) Cost-effectiveness analysis of various pertussis vaccination strategies primarily aimed at protecting infants in the Netherlands. Clinical Therapeutics 32:8, 1479-1495
CrossRef23
Philippe Gautret, Annelies Wilder-Smith. (2010) Vaccination against tetanus, diphtheria, pertussis and poliomyelitis in adult travellers. Travel Medicine and Infectious Disease 8:3, 155-160
CrossRef24
Ulrich Heininger. (2010) Update on pertussis in children. Expert Review of Anti-infective Therapy 8:2, 163-173
CrossRef25
Maarten J. Postma, Robin de Vries, John Roord. (2009) Conclusions on (cost-)effectiveness of pertussis booster vaccination strategies highly dependent on selections made in evidence review. Vaccine 27:52, 7242-7243
CrossRef26
Alexandre Borovkov, D. Mitch Magee, Andrey Loskutov, Jose A. Cano, Cheryl Selinsky, Jason Zsemlye, C. Rick Lyons, Kathryn Sykes. (2009) New classes of orthopoxvirus vaccine candidates by functionally screening a synthetic library for protective antigens. Virology 395:1, 97-113
CrossRef27
Wen-Chen Li, Tsung-Zu Wu, Yhu-Chering Huang, Li-Min Huang. (2009) Boostrix™: a reduced-dose acellular pertussis vaccine for use in adolescents and adults. Expert Review of Vaccines 8:10, 1317-1327
CrossRef28
N. K. Fry, J. Duncan, K. Wagner, O. Tzivra, N. Doshi, D. J. Litt, N. Crowcroft, E. Miller, R. C. George, T. G. Harrison. (2009) Role of PCR in the diagnosis of pertussis infection in infants: 5 years' experience of provision of a same-day real-time PCR service in England and Wales from 2002 to 2007. Journal of Medical Microbiology 58:8, 1023-1029
CrossRef29
James M Fleckenstein, Koushik Roy. (2009) Purification of recombinant high molecular weight two-partner secretion proteins from Escherichia coli. Nature Protocols 4:8, 1083-1092
CrossRef30
Peter McIntyre, Nicholas Wood. (2009) Pertussis in early infancy: disease burden and preventive strategies. Current Opinion in Infectious Diseases 22:3, 215-223
CrossRef31
Amanda F. Dempsey, Anne E. Cowan, Karen R. Broder, Katrina Kretsinger, Shannon Stokley, Sarah J. Clark. (2009) Adolescent Tdap Vaccine Use Among Primary Care Physicians. Journal of Adolescent Health 44:4, 387-393
CrossRef32
Natalia Mendoza, Parisa Ravanfar, Anita Satyaprakah, Sivaprabha Pillai, Rosella Creed. (2009) Existing antibacterial vaccines. Dermatologic Therapy 22:2, 129-142
CrossRef33
Peter B. McIntyre, Margaret A. Burgess, Annemarie Egan, Lode Schuerman, Bernard Hoet. (2009) Booster vaccination of adults with reduced-antigen-content diphtheria, Tetanus and pertussis vaccine: Immunogenicity 5 years post-vaccination. Vaccine 27:7, 1062-1066
CrossRef34
Claudia Rank, Helen E. Quinn, Peter B. McIntyre. (2009) PERTUSSIS VACCINE EFFECTIVENESS AFTER MASS IMMUNIZATION OF HIGH SCHOOL STUDENTS IN AUSTRALIA. The Pediatric Infectious Disease Journal 28:2, 152-153
CrossRef35
Mark Blatter, Leonard R. Friedland, Wayde M. Weston, Ping Li, Barbara Howe. (2009) Immunogenicity and safety of a tetanus toxoid, reduced diphtheria toxoid and three-component acellular pertussis vaccine in adults 19–64 years of age. Vaccine 27:5, 765-772
CrossRef36
Tanner W. Higginbotham, Kevin W. Cleveland. (2008) Decreasing Childhood Pertussis Infection Through Vaccination of the Elderly. The Consultant Pharmacist 23:12, 976-981
CrossRef37
Rolando Ulloa-Gutierrez, María L Avila-Aguero. (2008) Pertussis in Latin America: current situation and future vaccination challenges. Expert Review of Vaccines 7:10, 1569-1580
CrossRef38
Kathryn Sykes. (2008) Progress in the development of genetic immunization. Expert Review of Vaccines 7:9, 1395-1404
CrossRef39
Robert S. Wigton, Carol A. Darr, Kitty K. Corbett, Devin R. Nickol, Ralph Gonzales. (2008) How Do Community Practitioners Decide Whether to Prescribe Antibiotics for Acute Respiratory Tract Infections?. Journal of General Internal Medicine 23:10, 1615-1620
CrossRef40
Nicholas Wood, Peter McIntyre. (2008) Pertussis: review of epidemiology, diagnosis, management and prevention. Paediatric Respiratory Reviews 9:3, 201-212
CrossRef41
Ellyn Matthews, Gail Armstrong, Tammy Spencer. (2008) Pertussis Infection in a Baccalaureate Nursing Program: Clinical Implications, Emerging Issues, and Recommendations. The Journal of Continuing Education in Nursing 39:9, 419-426
CrossRef42
Marissa B Wilck, Lindsey R Baden. (2008) Vaccination after stem cell transplant: a review of recent developments and implications for current practice. Current Opinion in Infectious Diseases 21:4, 399-408
CrossRef43
Roy Roberts, Griselda Moreno, Daniela Bottero, Maria Emilia Gaillard, Matías Fingermann, Augusto Graieb, Martin Rumbo, Daniela Hozbor. (2008) Outer membrane vesicles as acellular vaccine against pertussis. Vaccine 26:36, 4639-4646
CrossRef44
Grace M. Lee, Marion Riffelmann, Carl Heinz Wirsing von Konig. (2008) Cost-effectiveness of adult pertussis vaccination in Germany. Vaccine 26:29-30, 3673-3679
CrossRef45
Courtney A Gidengil, Thomas J Sandora, Grace M Lee. (2008) Tetanus–diphtheria–acellular pertussis vaccination of adults in the USA. Expert Review of Vaccines 7:5, 621-634
CrossRef46
Qiushui He, Jussi Mertsola. (2008) Factors contributing to pertussis resurgence. Future Microbiology 3:3, 329-339
CrossRef47
L. COUDEVILLE, A. VAN RIE, P. ANDRE. (2008) Adult pertussis vaccination strategies and their impact on pertussis in the United States: evaluation of routine and targeted (cocoon) strategies. Epidemiology and Infection 136:05,
CrossRef48
Ellen S. Bamberger, Isaac Srugo. (2008) What is new in pertussis?. European Journal of Pediatrics 167:2, 133-139
CrossRef49
M. Abu Sin, N. Suttorp. (2008) Prävention von Infektionskrankheiten in Industrieländern. Der Internist 49:2, 162-169
CrossRef50
Ziad M. Shehab. 2008. Pertussis. , 589-595.
CrossRef51
Magda Campins Martí, Fernando A. Moraga Llop. (2008) Vacunación frente a la tos ferina en el adolescente y el adulto. Enfermedades Infecciosas y Microbiología Clínica 26, 12-19
CrossRef52
W A Orenstein, G T Mootrey, K Pazol, A R Hinman. (2007) Financing Immunization of Adults in the United States. Clinical Pharmacology & Therapeutics 82:6, 764-768
CrossRef53
Thuan Tong Tan, Kristian Riesbeck. (2007) Current progress of adhesins as vaccine candidates for Moraxella catarrhalis. Expert Review of Vaccines 6:6, 949-956
CrossRef54
William P. Goins, William Schaffner, Kathryn M. Edwards, Thomas R. Talbot. (2007) Healthcare Workers’ Knowledge and Attitudes About Pertussis and Pertussis Vaccination • . Infection Control and Hospital Epidemiology 28:11, 1284-1289
CrossRef55
D. Pinquier, C. Dumesnil, S. Galène-Gromez, S. Marret, L. Marpeau. (2007) Qui faut-il vacciner contre la coqueluche ?. Gynécologie Obstétrique & Fertilité 35:10, 1064-1068
CrossRef56
Jaffar A. Al-Tawfiq, Abbas AbuKhamsin. (2007) Bordetella pertussis infection in a highly vaccinated population in Saudi Arabia, 1996–2004. Journal of Infection 55:3, 249-253
CrossRef57
Sean R Bennett, Beth Brennan, Henry H Bernstein. (2007) Immunizations, neonatal hyperbilirubinemia and animal-induced injuries. Current Opinion in Pediatrics 19:4, 492-502
CrossRef58
Timothy J. Brickman, Mark T. Anderson, Sandra K. Armstrong. (2007) Bordetella iron transport and virulence. BioMetals 20:3-4, 303-322
CrossRef59
&NA;. (2007) Pertussis Vaccination of Health Care Workers. Journal of Occupational and Environmental Medicine 49:6, 700-702
CrossRef60
K. Edelman, Q. He, J. Makinen, A. Sahlberg, M. Haanpera, L. Schuerman, J. Wolter, J. Mertsola. (2007) Immunity to Pertussis 5 Years after Booster Immunization during Adolescence. Clinical Infectious Diseases 44:10, 1271-1277
CrossRef61
Annelies Wilder-Smith, Irving Boudville, Arul Earnest, Soh Low Heng, Hans L. Bock. (2007) Knowledge, Attitude, and Practices With Regard to Adult Pertussis Vaccine Booster in Travelers. Journal of Travel Medicine 14:3, 145-150
CrossRef62
John B. Robbins, Rachel Schneerson, Jerry M. Keith, Joseph Shiloach, Mark Miller, Birger Trollors. (2007) The rise in pertussis cases urges replacement of chemically-inactivated with genetically-inactivated toxoid for DTP. Vaccine 25:15, 2811-2816
CrossRef63
Allen S. Craig, Seth W. Wright, Kathryn M. Edwards, John W. Greene, MaryLou Haynes, Anthony D. Dake, William Schaffner. (2007) Outbreak of Pertussis on a College Campus. The American Journal of Medicine 120:4, 364-368
CrossRef64
Irini Daskalaki, Patricia Hennessey, Robin Hubler, Sarah S. Long. (2007) Resource Consumption in the Infection Control Management of Pertussis Exposure Among Healthcare Workers in Pediatrics • . Infection Control and Hospital Epidemiology 28:4, 412-417
CrossRef65
Kevin D. Forsyth, Carl-Heinz Wirsing von Konig, Tina Tan, Jaime Caro, Stanley Plotkin. (2007) Prevention of pertussis: Recommendations derived from the second Global Pertussis Initiative roundtable meeting. Vaccine 25:14, 2634-2642
CrossRef66
Margaret M. Cortese, Andrew L. Baughman, Kristin Brown, Pamela Srivastava. (2007) A “New Age” in Pertussis Prevention. American Journal of Preventive Medicine 32:3, 177-185.e1
CrossRef67
L. A. Mandell, R. G. Wunderink, A. Anzueto, J. G. Bartlett, G. D. Campbell, N. C. Dean, S. F. Dowell, T. M. File, D. M. Musher, M. S. Niederman, A. Torres, C. G. Whitney. (2007) Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults. Clinical Infectious Diseases 44:Supplement 2, S27-S72
CrossRef68
Grace M. Lee, Trudy V. Murphy, Susan Lett, Margaret M. Cortese, Katrina Kretsinger, Stephanie Schauer, Tracy A. Lieu. (2007) Cost Effectiveness of Pertussis Vaccination in Adults. American Journal of Preventive Medicine 32:3, 186-193.e2
CrossRef69
Jan T Poolman, Hans O Hallander. (2007) Acellular pertussis vaccines and the role of pertactin and fimbriae. Expert Review of Vaccines 6:1, 47-56
CrossRef70
J. Raymond, J.-B. Armengaud, C. Cosnes-Lambe, M. Chalumeau, E. Bosdure, H. Reglier-Poupet, M.-J. El Hajje, J.-L. Iniguez, F. Moulin, C. Poyart, D. Gendrel. (2007) Pertussis in young infants: apnoea and intra-familial infection. Clinical Microbiology and Infection 13:2,
CrossRef71
Joel I. Ward, James D. Cherry, Martin Lee, Swei‐Ju Chang. (2007) Reply to Baughman et al.. Clinical Infectious Diseases 44:1, 150-151
CrossRef72
J.A. Stockman. (2007) Combined Tetanus, Diphtheria, and 5-Component Pertussis Vaccine for Use in Adolescents and Adults. Yearbook of Pediatrics 2007, 224-226
CrossRef73
Sarah E Raguckas, Heather L VandenBussche, Carrie Jacobs, Michael E Klepser. (2007) Pertussis Resurgence: Diagnosis, Treatment, Prevention, and Beyond. Pharmacotherapy 27:1, 41-52
CrossRef74
Andrew L. Baughman, Margaret M. Cortese, Barbara A. Slade. (2007) Incidence of Bordetella pertussis Infection in Adolescents and Adults. Clinical Infectious Diseases 44:1, 149-150
CrossRef75
Joanne M. Langley, Gerald Predy, R. Guasparini, Barbara Law, Francisco Diaz-Mitoma, Paul Whitstitt, Bruce Tapiero, Marc Dionne, A. Tomovici, Elaine Mills, Scott A. Halperin. (2007) An adolescent–adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4–6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. Vaccine 25:6, 1121-1125
CrossRef76
Alberto E. Tozzi, Elisabetta Pandolfi, Lucia Pastore Celentano, Marco Massari, Stefania Salmaso, Marta L. Ciofi degli Atti. (2007) Comparison of pertussis surveillance systems in Europe. Vaccine 25:2, 291-297
CrossRef77
Wenzel, Richard P., Fowler, Alpha A. III, . (2006) Acute Bronchitis. New England Journal of Medicine 355:20, 2125-2130
Full Text78
Peter Vranken, Michelle Pogue, Christine Romalewski, Raoult Ratard. (2006) Outbreak of pertussis in a neonatal intensive care unit--Louisiana, 2004. American Journal of Infection Control 34:9, 550-554
CrossRef79
Joseph R. DiPersio. (2006) Snapshots for November 2006. Infectious Diseases in Clinical Practice 14:6, 341-344
CrossRef80
Joel I. Ward, James D. Cherry, Swei‐Ju Chang, Susan Partridge, Wendy Keitel, Kathryn Edwards, Martin Lee, John Treanor, David P. Greenberg, Stephen Barenkamp, David I. Bernstein, Robert Edelman, . (2006) Bordetella Pertussis Infections in Vaccinated and Unvaccinated Adolescents and Adults, as Assessed in a National Prospective Randomized Acellular Pertussis Vaccine Trial (APERT). Clinical Infectious Diseases 43:2, 151-157
CrossRef81
Ulrich Heininger, James D Cherry. (2006) Pertussis immunisation in adolescents and adults – Bordetella pertussis epidemiology should guide vaccination recommendations. Expert Opinion on Biological Therapy 6:7, 685-697
CrossRef82
Jennifer N. Post. (2006) Immunizations, neonatal jaundice and animal-induced injuries. Current Opinion in Pediatrics 18:3, 330-335
CrossRef83
C Mary Healy, Carol J Baker. (2006) Prospects for prevention of childhood infections by maternal immunization. Current Opinion in Infectious Diseases 19:3, 271-276
CrossRef84
Natasha S Crowcroft, Richard G Pebody. (2006) Recent developments in pertussis. The Lancet 367:9526, 1926-1936
CrossRef85
Kathryn M. Edwards, Thomas R. Talbot. (2006) The Challenges of Pertussis Outbreaks in Healthcare Facilities: Is There A Light at the End of the Tunnel? • . Infection Control and Hospital Epidemiology 27:6, 537-540
CrossRef86
Jann Storsaeter, Joanne Wolter. (2006) Is there a need for a new generation of vaccines against pertussis?. Expert Opinion on Emerging Drugs 11:2, 195-205
CrossRef87
A. Calugar, I. R. Ortega-Sanchez, T. Tiwari, L. Oakes, J. A. Jahre, T. V. Murphy. (2006) Nosocomial Pertussis: Costs of an Outbreak and Benefits of Vaccinating Health Care Workers. Clinical Infectious Diseases 42:7, 981-988
CrossRef88
G Kochethu, F J Clark, C F Craddock. (2006) Pertussis: should we vaccinate post transplant?. Bone Marrow Transplantation 37:8, 793-794
CrossRef89
Sylvia H Yeh, ChrisAnna M Mink. (2006) Shift in the Epidemiology of Pertussis Infection. Drugs 66:6, 731-741
CrossRef90
D SNYDMAN. (2006) Efficacy of an Acellular Pertussis Vaccine Among Adolescents and AdultsWard JI, for the APERT Study Group (UCLA, Torrance, Calif; et al) N Engl J Med 353:1555–1563, 2005§. Yearbook of Medicine 2006, 118-119
CrossRef91
Halperin, Scott A., . (2005) Pertussis — A Disease and Vaccine for All Ages. New England Journal of Medicine 353:15, 1615-1617
Full Text
