Original Article
Electronic Alerts to Prevent Venous Thromboembolism among Hospitalized Patients
N Engl J Med 2005; 352:969-977March 10, 2005
- Abstract
Background
Prophylaxis against deep-vein thrombosis in hospitalized patients remains underused. We hypothesized that the use of a computer-alert program to encourage prophylaxis might reduce the frequency of deep-vein thrombosis among high-risk hospitalized patients.
Methods
We developed a computer program linked to the patient database to identify consecutive hospitalized patients at risk for deep-vein thrombosis in the absence of prophylaxis. The program used medical-record numbers to randomly assign 1255 eligible patients to an intervention group, in which the responsible physician was alerted to a patient's risk of deep-vein thrombosis, and 1251 patients to a control group, in which no alert was issued. The physician was required to acknowledge the alert and could then withhold or order prophylaxis, including graduated compression stockings, pneumatic compression boots, unfractionated heparin, low-molecular-weight heparin, or warfarin. The primary end point was clinically diagnosed, objectively confirmed deep-vein thrombosis or pulmonary embolism at 90 days.
Results
More patients in the intervention group than in the control group received mechanical prophylaxis (10.0 percent vs. 1.5 percent, P<0.001) or pharmacologic prophylaxis (23.6 percent vs. 13.0 percent, P<0.001). The primary end point occurred in 61 patients (4.9 percent) in the intervention group, as compared with 103 (8.2 percent) in the control group; the Kaplan–Meier estimates of the likelihood of freedom from deep-vein thrombosis or pulmonary embolism at 90 days were 94.1 percent (95 percent confidence interval, 92.5 to 95.4 percent) and 90.6 percent (95 percent confidence interval, 88.7 to 92.2 percent), respectively (P<0.001). The computer alert reduced the risk of deep-vein thrombosis or pulmonary embolism at 90 days by 41 percent (hazard ratio, 0.59; 95 percent confidence interval, 0.43 to 0.81; P=0.001).
Conclusions
The institution of a computer-alert program increased physicians' use of prophylaxis and markedly reduced the rates of deep-vein thrombosis and pulmonary embolism among hospitalized patients at risk.
Media in This Article
Figure 1
Kaplan–Meier Estimates of the Absence of Deep-Vein Thrombosis or Pulmonary Embolism in the Intervention Group and the Control Group.Table 1
Baseline Characteristics of the Patients.Article Activity
- Article
Despite the existence of detailed European1 and North American2 consensus guidelines, the use of prophylaxis against venous thromboembolism continues to be spotty. Randomized, controlled trials of hospitalized medical patients3-5 have shown that certain measures safely prevent venous thromboembolism, yet European6,7 and North American8-10 surveys show persistent underuse of prophylaxis. In a registry of 5451 consecutive patients with ultrasonographically confirmed deep-vein thrombosis at 183 U.S. institutions,10 only 42 percent of inpatients had received prophylaxis within 30 days before deep-vein thrombosis developed. Although approaches involving continuing medical education11 and computerized electronic alerts12,13 can increase physicians' use of prophylaxis against venous thromboembolism, it is not known whether the use of an electronic alert system can actually reduce the rate of deep-vein thrombosis.
Brigham and Women's Hospital in Boston has made concerted efforts to increase physicians' awareness of risk factors for venous thromboembolism and their understanding of the effectiveness of prevention strategies. Frequent educational programs that focus on the necessity of venous thromboembolism prophylaxis are convened. The order-entry system is programmed to suggest prophylaxis if an order for bed rest is entered. Nevertheless, a two-year audit found that prophylaxis was used in only 52 percent of patients in whom deep-vein thrombosis developed while they were hospitalized for other reasons.14 Therefore, as a quality-improvement initiative, we undertook a randomized, controlled study of 2506 hospitalized patients to evaluate a strategy of issuing or withholding electronic alerts to physicians whose patients were not receiving prophylaxis against deep-vein thrombosis.
Methods
Study Design
We developed a computer program to identify consecutive hospitalized patients at increased risk for venous thromboembolism. The program was linked to the patient database (Partners Information Systems) of Brigham and Women's Hospital. The study was approved by the human research committee of Partners HealthCare System. The requirement for informed consent was waived.
From September 2000 to January 2004, we identified 2506 consecutive hospitalized patients from medical and surgical services who were at least 18 years of age and who were at increased risk for venous thromboembolism. Patients from the Department of Neurology, the Newborn Service, and the Neonatal Intensive Care Unit were excluded, as were patients receiving mechanical or pharmacologic prophylaxis.
The principal investigator (Dr. Goldhaber) designed the study, edited the manuscript, and vouches for the data and analyses. Drs. Koo, Quiroz, and Cooper gathered data. Dr. Kucher performed data analyses and drafted the manuscript.
Identification of Patients at Risk for Venous Thromboembolism
The computer program used eight common risk factors to determine each hospitalized patient's risk profile for venous thromboembolism. Each risk factor was weighted according to a point scale: the major risk factors of cancer, prior venous thromboembolism, and hypercoagulability were assigned a score of 3; the intermediate risk factor of major surgery was assigned a score of 2; and the minor risk factors of advanced age, obesity, bed rest, and the use of hormone-replacement therapy or oral contraceptives were assigned a score of 1. An increased risk of venous thromboembolism was defined as a cumulative risk score of at least 4, so that patients who had at least one major risk factor and at least one intermediate risk factor or minor risk factor were eligible for the study. In the absence of a major risk factor, patients who had at least one intermediate risk factor and at least two minor risk factors were also eligible. Daily screening of the computer-alert program permitted us to identify and enroll patients who initially had a venous thromboembolism risk score of less than 4 but whose score increased to 4 or higher during hospitalization.
The program used current lists of inpatient diagnoses to identify patients with the following types of cancer: cervical, colon, lung, ovarian, prostate, rectal, renal, thyroid, uterine, pancreatic, liver, stomach, brain, esophageal, and head and neck, as well as sarcoma and melanoma. In addition, the admitting diagnoses were screened for cancer coded according to the International Classification of Diseases, 9th Revision (ICD-9), as codes 149.0 to 172.99 and 174.0 to 209.99. Inpatient and outpatient records were checked to identify patients with a personal history of deep-vein thrombosis or pulmonary embolism, as well as those with a history of venous thromboembolism, as indicated by ICD-9 codes 415.1, 415.19, 453.8, 453.9, and 671.31 to 671.50.
Hypercoagulable states were identified on the basis of laboratory test results, including the presence of factor V Leiden, lupus anticoagulant, and anticardiolipin antibodies, in the database. Major surgery was defined as any surgery lasting more than 60 minutes. Bed rest was defined as an active order for bed rest that was not related to surgery. Advanced age was defined as an age of more than 70 years. If data on weight and height were available, the program calculated the body-mass index (the weight in kilograms divided by the square of the height in meters). Obesity was defined as a body-mass index of more than 29. If weight and height data were not available, inpatient and outpatient records were screened for a diagnosis of obesity and for the ICD-9 code for obesity (278.0). Ongoing use of hormone-replacement therapy or oral contraceptives was identified by reviewing patients' active medications.
Screening for Venous Thromboembolism Prophylaxis
If the cumulative risk score for venous thromboembolism was at least 4, the computer program reviewed orders to identify the ongoing use of mechanical or pharmacologic prophylactic measures. Electronic orders were searched for mechanical prophylactic measures, including the use of graduated-compression stockings or intermittent pneumatic-compression boots. Lists of active medications were screened for the presence of prophylactic pharmacologic measures, including the use of unfractionated heparin, enoxaparin, dalteparin, danaparoid, hirudin, or warfarin. Of 13,922 patients with a risk score for venous thromboembolism of at least 4, 11,416 (82.0 percent) had received mechanical or pharmacologic prophylaxis a priori and 2506 (18.0 percent) had not received it.
Randomization and Electronic Alerts
Patients with even medical-record numbers were assigned to the intervention group, and those with odd medical-record numbers were assigned to the control group, without further stratification. Among the 2506 eligible patients, 1255 were assigned to the intervention group, in which the responsible physician received one electronic alert about the risk of venous thromboembolism, and 1251 to the control group, in which no alert was issued. Overall, 120 physicians were responsible for the study patients: 104 physicians were assigned to a median of 12 patients in the intervention group (range, 2 to 19), and 102 physicians to a median of 13 patients in the control group (range, 2 to 18). Thirty-four physicians (28.3 percent) were assigned to treat only patients in one group: 18 to the intervention group alone and 16 to the control group alone. Physicians responsible for patients in the control group were not aware that these patients were being followed for clinical events.
Each responsible physician had to acknowledge the computer alert and could then withhold prophylaxis or, on the same computer screen, order prophylaxis with options that included graduated-compression stockings, intermittent pneumatic-compression boots, unfractionated heparin, low-molecular-weight heparin, or warfarin. In addition, the computer-alert screen was linked to the hospital's venous-thromboembolism–prevention guidelines, which provided drug regimens for various indications according to published consensus guidelines.2 Guidelines for the prevention of venous thromboembolism were also available for patients in the control group, but no specific prompt was provided to use them.
Follow-up
We conducted a 90-day follow-up of all study patients, reviewing their medical records in the patient database of Brigham and Women's Hospital. Clinical events were identified with the use of information from the index hospitalization, subsequent hospitalizations, and office visits, including discharge summaries, physician's notes, blood-test results, vascular-laboratory reports, nuclear-medicine reports, and radiology reports. In addition, the Social Security Death Index was used to identify patients who died during the 90-day period.
Overall, 2361 patients (94.2 percent) had follow-up data beyond the index hospitalization, and 145 patients (5.8 percent) were lost to follow-up. Of the patients lost to follow-up, 78 were in the intervention group and 67 were in the control group (P=0.39). A total of 2007 patients (80.1 percent) had outpatient visits, and 1008 (40.2 percent) were rehospitalized during the 90 days after randomization.
Data Collection and Study End Points
The primary end point was clinically diagnosed deep-vein thrombosis or pulmonary embolism at 90 days. For patients with more than one event, only the first event was counted. Safety end points included total mortality at 30 days and the rate of hemorrhagic events at 90 days. We defined major bleeding as intracranial, intraocular, retroperitoneal, or pericardial bleeding, or bleeding that required surgical intervention or that resulted in a hemoglobin loss of more than 3 g per deciliter.15
Deep-vein thrombosis was diagnosed if there was ultrasonographic evidence of the loss of vein compressibility or evidence of a filling defect on conventional contrast venography.16 Pulmonary embolism was diagnosed on the basis of findings on ventilation–perfusion scanning,17 computed tomography of the chest with contrast medium,18 or conventional pulmonary angiography.19 Events clinically suspected to be related to venous thromboembolism without objective confirmation of the diagnosis were not counted. Three investigators who were unaware of patients' group assignments adjudicated all end points.
Statistical Analysis
We initially estimated that we would need to enroll 1400 patients for the study to have a statistical power of 90 percent (two-sided alpha of 5 percent), given an estimated 50 percent rate of use of prophylaxis against venous thromboembolism in the intervention group, a 10 percent rate of the primary end point in the control group, and an odds ratio of 0.50 for the primary end point in the intervention group as compared with the control group. After 700 patients had been enrolled, the protocol was modified to increase the sample size to 2500 patients, because the rate of use of prophylaxis against venous thromboembolism in the intervention group was lower than expected. At that time, no clinical end-point data had been obtained. An interim analysis of efficacy and safety undertaken after approximately half the expected information was obtained indicated that the predefined boundaries for early stopping had not been crossed, on the basis of the O'Brien–Fleming spending function according to the method of Lan and DeMets.20
We used Wilcoxon rank-sum tests to compare the distributions of continuous variables between groups and chi-square tests or Fisher's exact tests to compare categorical variables. The primary analysis was performed with the use of Greenwood's formula for the difference between the intervention group and the control group in the Kaplan–Meier estimates of freedom from deep-vein thrombosis or pulmonary embolism on day 90. The log-rank test was used to estimate the cumulative probability of the primary end point in the intervention and control groups. We used the proportional-hazards model to estimate the relative hazard of clinical end points associated with the computer alert and obtained 95 percent confidence intervals from this model. We also used the proportional-hazards model to evaluate the effect of the computer alert on the primary end point in clinically important subgroups. In addition, we assessed the effect of the computer alert in subgroups by including a term for the interaction between group assignment and each clinical factor. All reported P values are two-sided.
Results
Characteristics of the Patients
The intervention and control groups were well balanced with respect to baseline characteristics (Table 1Table 1
Baseline Characteristics of the Patients.). Overall, 52.9 percent were women, and 47.1 percent were men. Almost two thirds had a risk score for venous thromboembolism of 4; 37.2 percent had a risk score ranging from 5 to 8. Overall, 434 of the patients (17.3 percent) had undergone surgery or had trauma. The remaining 2072 (82.7 percent) had been hospitalized for other reasons. The most common coexisting conditions were cancer (in 79.7 percent), hypertension (in 34.4 percent), and infection (in 30.3 percent); 20.3 percent had prior venous thromboembolism.Prophylaxis against Venous Thromboembolism
Prophylactic measures were ordered for 421 of the 1255 patients in the intervention group (33.5 percent) and 182 of the 1251 patients in the control group (14.5 percent, P<0.001). The intervention group had higher rates of use of both mechanical prophylaxis (10.0 percent vs. 1.5 percent, P<0.001) and pharmacologic prophylaxis (23.6 percent vs. 13.0 percent, P<0.001) than the control group (Table 2Table 2
Prophylactic Measures against Venous Thromboembolism.). The difference in the use of prophylaxis between the groups was mainly driven by increased use of graduated-compression stockings, intermittent pneumatic-compression boots, and subcutaneous unfractionated heparin in the intervention group.Patients who received prophylaxis were older than those who did not receive prophylaxis (mean [±SD] age, 66±15 vs. 59±17 years; P<0.001), and they had a lower rate of cancer (70.7 percent vs. 82.6 percent, P<0.001) and higher frequencies of congestive heart failure (16.6 percent vs. 8.8 percent, P<0.001), coronary artery disease (21.6 percent vs. 15.1 percent, P<0.001), chronic lung disease (15.3 percent vs. 11.5 percent, P=0.01), prior venous thromboembolism (32.8 percent vs. 16.3 percent, P<0.001), hypertension (39.3 percent vs. 32.9 percent, P=0.004), and recent surgery or trauma (37.3 percent vs. 14.2 percent, P<0.001). These covariates were predictive of the use of prophylaxis in both the intervention and control groups.
End Points
Efficacy
The primary end point of deep-vein thrombosis or pulmonary embolism at 90 days occurred in 61 patients in the intervention group (4.9 percent), as compared with 103 patients in the control group (8.2 percent); the Kaplan–Meier estimates of the absence of venous thromboembolism at 90 days were 94.1 percent (95 percent confidence interval, 92.5 to 95.4 percent) and 90.6 percent (95 percent confidence interval, 88.7 to 92.2 percent), respectively (P<0.001) (Figure 1Figure 1
Kaplan–Meier Estimates of the Absence of Deep-Vein Thrombosis or Pulmonary Embolism in the Intervention Group and the Control Group.). The computer alert reduced the risk of venous thromboembolism at 90 days by 41 percent (hazard ratio, 0.59; 95 percent confidence interval, 0.43 to 0.81; P=0.001). The computer alert was similarly effective in reducing the rates of deep-vein thrombosis of the legs and pulmonary embolism (Table 3Table 3
Study End Points.).The electronic alert also reduced the rates of venous thromboembolism at 90 days in clinically important subgroups (Table 4Table 4
Hazard Ratios for the Primary End Point at 90 Days in Clinically Important Subgroups.). Proportional-hazards models did not reveal any significant interaction between the effect of the computer alert and any subgroup.At 90 days, venous thromboembolism had occurred in 31 of 603 patients who received prophylaxis (5.1 percent), as compared with 133 of 1903 patients who did not receive prophylaxis (7.0 percent); the Kaplan–Meier estimates of the absence of venous thromboembolism at 90 days were 93.6 percent (95 percent confidence interval, 91.0 to 95.5 percent) and 92.0 percent (95 percent confidence interval, 90.5 to 93.2 percent), respectively (P=0.08). In the intervention group, venous thromboembolism occurred in 20 of 421 patients who received prophylaxis (4.8 percent), as compared with 41 of 834 who did not receive prophylaxis (4.9 percent); the Kaplan–Meier estimates of the absence of venous thromboembolism at 90 days were 94.3 percent (95 percent confidence interval, 92.3 to 95.3 percent) and 93.8 percent (95 percent confidence interval, 90.6 to 96.0 percent), respectively (P=0.82). In the control group, venous thromboembolism occurred in 11 of 182 patients who received prophylaxis (6.0 percent), as compared with 91 of 1069 patients who did not receive prophylaxis (8.5 percent), and the respective Kaplan–Meier estimates were 93.1 percent (95 percent confidence interval, 87.8 to 96.1 percent) and 90.2 percent (95 percent confidence interval, 88.1 to 91.9 percent) (P=0.23).
Safety
The overall rate of death was 13.2 percent at 30 days and 22.4 percent at 90 days, with no significant difference between the groups (Table 3). There was no increase in the rate of major or minor hemorrhage at 30 days in the intervention group.
Discussion
The computer program facilitated the identification of hospitalized patients at increased risk for venous thromboembolism in the absence of prophylaxis, more than doubling the rate of orders for prophylaxis (from 14.5 percent to 33.5 percent), and reduced the overall rate of venous thromboembolism at 90 days by 41 percent, without an increase in bleeding or mortality rates. The reduction in clinically diagnosed and objectively confirmed venous thromboembolism was due mainly to a decreased frequency of pulmonary embolism and proximal-leg deep-vein thrombosis.
Our study population consisted mostly of medical patients (82.7 percent) who were severely ill; there was a high prevalence of cancer (79.7 percent) and a three-month mortality rate that exceeded 20 percent. The rate of deep-vein thrombosis of the upper extremities was high among patients with cancer and most likely due to the frequent use of chemotherapy through central venous catheters.21 The prophylaxis rate in the intervention group was low (33.5 percent) in this ill population; many may have had conditions precluding the use of pharmacologic prophylaxis, but there is no obvious explanation for the failure to order mechanical prophylaxis, such as graduated-compression stockings or intermittent pneumatic-compression boots. Although we did not track contraindications to prophylaxis, they were probably evenly distributed between the intervention and control groups owing to the randomized design of the trial.
The computer alert was effective in patients with a wide spectrum of major risk factors for venous thromboembolism, such as advanced age, prior venous thromboembolism, and cancer. The computer alert was similarly efficacious in reducing the rate of the primary end point in patients with a risk score for venous thromboembolism of 4 and those with higher risk scores. However, the use of prophylaxis against venous thromboembolism has not significantly reduced the overall mortality rate in any major study of prevention of venous thromboembolism among hospitalized medical patients,3-5,22,23 including ours; none were adequately powered to investigate the effect of prophylaxis against venous thromboembolism on overall mortality.
In our study, the reduction in events related to venous thromboembolism may be explained only partly by increased use of prophylaxis. Assignment to the intervention group itself decreased such events through day 90: for patients in this group, the computer alert itself may have increased the physicians' awareness of a high-risk situation, even though they did not administer mechanical or pharmacologic prophylaxis. Our study design did not allow the assessment of additional preventive measures, such as early ambulation or physiotherapy, that may have decreased the rate of venous thromboembolism among patients in the intervention group. In addition, the fact that physicians treating patients in the intervention group were aware that their patients were monitored may have further affected the rate of venous thromboembolism. However, since the use of prophylaxis was not randomized but was up to the individual physician, it may not be appropriate to compare patients who received prophylaxis with those who did not receive prophylaxis. Therefore, the results of analyses of the study groups according to prophylaxis status must be interpreted with caution.
We cannot rule out the possibility of diagnostic bias, since the administration of prophylaxis was not blinded and testing for venous thromboembolism was not routinely performed. It is therefore possible that physicians were more likely to order an imaging test for patients with symptoms who had not received prophylaxis than for those who had received prophylaxis. On the other hand, testing may not have been performed in symptomatic patients with limited life expectancy or contraindications to anticoagulation therapy, even if prophylaxis was not administered.
Because of the high rate of use of prophylaxis among the 13,922 patients with a risk score for venous thromboembolism of at least 4, the overall effect of the computer program was weak. The rate of use of prophylaxis among these patients might have increased from 84.6 percent without the computer-alert program to 88.0 percent if computer reminders had been issued for all 2506 eligible patients. The study intervention involved physicians, but randomization involved patients. Therefore, we were not able to assess whether physicians had an effect on the use of prophylaxis and rate of events related to venous thromboembolism. Since most physicians treated both intervention and control patients, it is likely that receiving computer reminders for patients in the intervention group also affected physicians' use of prophylaxis in some patients in the control group.
Computer-based clinical decision-making systems may be less effective for the management of chronic disease than they are for the management of acute disease,24 but they appear to be particularly useful for preventive care and dosing regimens in hospitals.25-29 In a randomized, controlled trial of 6371 hospitalized patients,12 the use of computerized reminders increased orders for unfractionated heparin from 18.9 percent in the control group to 32.2 percent in the intervention group. In a French orthopedic-surgery department, the use of electronic reminders increased compliance with guidelines for the prevention of venous thromboembolism from 82.8 percent in the control group to 94.9 percent in the intervention group.13 These two studies, however, did not analyze outcomes among the patients. Thus, our data — taken together with these two prior studies — support the use of a computer-generated alert to reduce clinical events among hospitalized patients at increased risk for venous thromboembolism.
Key elements in making the study software work were the availability of a full and integrated database, which allowed us to gather the data needed to determine each patient's risk score for venous thromboembolism; a robust, rule-based alerting system capable of being triggered in a variety of ways; and an existing and well-accepted notification system with which our physicians were already familiar. Our design may be useful at other institutions; however, it may require modification, because other hospitals may use different computer languages and database layouts, may not have an integrated data system, and may use different terms to identify patients who are at high risk in the absence of prophylaxis.
Our results suggest that hospitals with adequate information-systems resources should consider implementing electronic alerts to increase physicians' awareness of the risk of venous thromboembolism, to increase the use of prophylaxis, and to reduce the rates of deep-vein thrombosis and pulmonary embolism.
Dr. Goldhaber reports having received clinical research support from Bristol-Myers Squibb and GlaxoSmithKline and having served as a consultant for Sanofi-Aventis, Pfizer, and AstraZeneca.
Source Information
From the Departments of Medicine (N.K., S.K., R.Q., S.Z.G.), Cardiovascular Division, Harvard Medical School and Brigham and Women's Hospital, Boston; the Department of Medicine, University of Pennsylvania Medical Center, Philadelphia (J.M.C.); and Partners HealthCare System, Wellesley, Mass. (M.D.P., B.S.).
Address reprint requests to Dr. Goldhaber at the Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, or at sgoldhaber@partners.org.
- References
References
1
Nicolaides AN ,Breddin HK ,Fareed J , et al. Prevention of venous thromboembolism: International Consensus Statement: guidelines compiled in accordance with the scientific evidence. Int Angiol 2001;20:1-37
CrossRef | Web of Science | Medline2
Geerts WH ,Heit JA ,Clagett GP , et al. Prevention of venous thromboembolism. Chest 2001;119:Suppl:132S-175S
CrossRef | Web of Science | Medline3
Leizorovicz A ,Cohen AT ,Turpie AGG ,Olsson CG ,Vaitkus PT ,Goldhaber SZ . Randomized placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients. Circulation 2004;110:874-879
CrossRef | Web of Science | Medline4
Samama MM ,Cohen AT ,Darmon JY , et al. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. N Engl J Med 1999;341:793-800
Full Text | Web of Science | Medline5
Cohen AT ,Gallus AS ,Lassen MR , et al. Fondaparinux versus placebo for the prevention of venous thromboembolism in acutely ill medical patients (ARTEMIS). J Thromb Haemost 2003;1:Suppl 1:2040-2040 abstract.
CrossRef | Web of Science6
Ageno W ,Squizzato A ,Ambrosini F , et al. Thrombosis prophylaxis in medical patients: a retrospective review of clinical practice patterns. Haematologica 2002;87:746-750
Web of Science | Medline7
Alikhan R ,Wilmott R ,Agrawal S . Use of thromboprophylaxis in nonsurgical patients: survey of a London teaching hospital. Blood 2001;98:Suppl:271a-271a abstract.
Web of Science8
Keane MG ,Ingenito EP ,Goldhaber SZ . Utilization of venous thromboembolism prophylaxis in the medical intensive care unit. Chest 1994;106:13-14
CrossRef | Web of Science | Medline9
Hirsch DR ,Ingenito EP ,Goldhaber SZ . Prevalence of deep venous thrombosis among patients in medical intensive care. JAMA 1995;274:335-337
CrossRef | Web of Science | Medline10
Goldhaber SZ ,Tapson VF . A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol 2004;93:259-262
CrossRef | Web of Science | Medline11
Anderson FA Jr ,Wheeler HB ,Goldberg RJ ,Hosmer DW ,Forcier A ,Patwardhan NA . Prospective study of the impact of continuing medical education and quality assurance programs on use of prophylaxis for venous thromboembolism. Arch Intern Med 1994;154:669-677
CrossRef | Web of Science | Medline12
Dexter PR ,Perkins S ,Overhage JM ,Maharry K ,Kohler RB ,McDonald CJ . A computerized reminder system to increase the use of preventive care for hospitalized patients. N Engl J Med 2001;345:965-970
Full Text | Web of Science | Medline13
Durieux P ,Nizard R ,Ravaud P ,Mounier N ,Lepage E . A clinical decision support system for prevention of venous thromboembolism: effect on physician behavior. JAMA 2000;283:2816-2821
CrossRef | Web of Science | Medline14
Goldhaber SZ ,Dunn K ,MacDougall RC . New onset of venous thromboembolism among hospitalized patients at Brigham and Women's Hospital is caused more often by prophylaxis failure than by withholding treatment. Chest 2000;118:1680-1684
CrossRef | Web of Science | Medline15
Kucher N ,Castellanos LR ,Quiroz R ,Koo S ,Fanikos J ,Goldhaber SZ . Time trends in warfarin-associated hemorrhage. Am J Cardiol 2004;94:403-406
CrossRef | Web of Science | Medline16
Becker DM ,Philbrick JT ,Abbitt PL . Real-time ultrasonography for the diagnosis of lower extremity deep venous thrombosis: the wave of the future? Arch Intern Med 1989;149:1731-1734
CrossRef | Web of Science | Medline17
The PIOPED Investigators
CrossRef | Web of Science18
Remy-Jardin M ,Remy J ,Deschildre F , et al. Diagnosis of pulmonary embolism with spiral CT: comparison with pulmonary angiography and scintigraphy. Radiology 1996;200:699-706
Web of Science | Medline19
Stein PD ,Athanasoulis C ,Alavi A , et al. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation 1992;85:462-468
Web of Science | Medline20
Lan KKG ,DeMets DL . Discrete sequential boundaries for clinical trials. Biometrika 1983;70:659-663
CrossRef | Web of Science21
Joffe HV ,Kucher N ,Tapson VF ,Goldhaber SZ . Upper extremity deep vein thrombosis: a prospective registry of 592 patients. Circulation 2004;110:1605-1611
CrossRef | Web of Science | Medline22
Gardlund B . Randomised, controlled trial of low-dose heparin for prevention of fatal pulmonary embolism in patients with infectious diseases. Lancet 1996;347:1357-1361
CrossRef | Web of Science | Medline23
Bergmann JF ,Caulin C . Heparin prophylaxis in bedridden patients. Lancet 1996;348:205-206
CrossRef | Web of Science | Medline24
Eccles M ,McColl E ,Steen N , et al. Effect of computerised evidence based guidelines on management of asthma and angina in adults in primary care: cluster randomised controlled trial. BMJ 2002;325:941-941
CrossRef | Web of Science | Medline25
Kuperman GJ ,Gibson RF . Computer physician order entry: benefits, costs, and issues. Ann Intern Med 2003;139:31-39
Web of Science | Medline26
Bates DW ,Gawande AA . Improving safety with information technology. N Engl J Med 2003;348:2526-2534
Full Text | Web of Science | Medline27
Berwick DM . Errors today and errors tomorrow. N Engl J Med 2003;348:2570-2572
Full Text | Web of Science | Medline28
Bobb A ,Gleason K ,Husch M ,Feinglass J ,Yarnold PR ,Noskin GA . The epidemiology of prescribing errors: the potential impact of computerized prescriber order entry. Arch Intern Med 2004;164:785-792
CrossRef | Web of Science | Medline29
Hunt DL ,Haynes RB ,Hanna SE ,Smith K . Effects of computer-based clinical decision support systems on physician performance and patient outcomes: a systematic review. JAMA 1998;280:1339-1346
CrossRef | Web of Science | Medline
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Moshe Vardi, Michal Haran. (2011) Venous thromboembolism prophylaxis of acutely ill hospitalized medical patients. Are we over-treating our patients?. European Journal of Internal Medicine
CrossRef9
R. Samuel Mayer, Michael B. Streiff, Deborah B. Hobson, Daniel E. Halpert, Sean M. Berenholtz. (2011) Evidence-based Venous Thromboembolism Prophylaxis is Associated With a Six-fold Decrease in Numbers of Symptomatic Venous Thromboembolisms in Rehabilitation Inpatients. PM&R 3:12, 1111-1115.e1
CrossRef10
J. D. Mitchell, J. F. Collen, S. Petteys, A. B. Holley. (2011) A Simple Reminder System Improves Venous Thromboembolism Prophylaxis Rates and Reduces Thrombotic Events For Hospitalized Patients. Journal of Thrombosis and Haemostasisno-no
CrossRef11
M. Chavez-MacGregor, H. Zhao, M. Kroll, S. Fang, N. Zhang, G. N. Hortobagyi, T. A. Buchholz, Y.- C. Shih, S. H. Giordano. (2011) Risk factors and incidence of thromboembolic events (TEEs) in older men and women with breast cancer. Annals of Oncology 22:11, 2394-2402
CrossRef12
Sharon A. Van Wicklin. (2011) Implementing AORN Recommended Practices for Prevention of Deep Vein Thrombosis. AORN 94:5, 443-454
CrossRef13
Meyer M. Samama, Sophie Combe, Jacqueline Conard, Marie-Helene Horellou. (2011) Risk assessment models for thromboprophylaxis of medical patients. Thrombosis Research
CrossRef14
Raquel Barba, Antonio Zapatero, Javier Marco, Juan E. Losa, Susana Plaza, Jose Manuel Casas, Jesús Canora. (2011) Venous thromboembolism in COPD hospitalized patients. Journal of Thrombosis and Thrombolysis
CrossRef15
Kenneth C. Wilson, Geno J. Merli. (2011) Performance measures for improving the prevention of venous thromboembolism: achievement in clinical practice. Journal of Thrombosis and Thrombolysis 32:3, 293-302
CrossRef16
Scott C. Woller, Scott M. Stevens, Jason P. Jones, James F. Lloyd, R. Scott Evans, Valerie T. Aston, C. Gregory Elliott. (2011) Derivation and Validation of a Simple Model to Identify Venous Thromboembolism Risk in Medical Patients. The American Journal of Medicine 124:10, 947-954.e2
CrossRef17
Patricia Gallardo Jiménez, Ricardo Guijarro Merino, Verónica Vallejo Herrera, David Sánchez Morales, Aurora Villalobos Sánchez, Juan Ignacio Perelló González-Moreno, Ricardo Gómez-Huelgas. (2011) Riesgo de enfermedad tromboembólica venosa en pacientes hospitalizados no quirúrgicos. Grado de acuerdo entre la guía PRETEMED y las recomendaciones de la viii conferencia del American College of Chest Physicians. Medicina Clínica
CrossRef18
J. E. Stark, W. J. Smith. (2011) Standard or extended-duration prophylaxis in medical patients? A review of the evidence. Journal of Thrombosis and Thrombolysis 32:3, 318-327
CrossRef19
Edward Janus, Anmol Bassi, David Jackson, Harshal Nandurkar, Mark Yates. (2011) Thromboprophylaxis use in medical and surgical inpatients and the impact of an electronic risk assessment tool as part of a multi-factorial intervention. A report on behalf of the elVis study investigators. Journal of Thrombosis and Thrombolysis 32:3, 279-287
CrossRef20
Behnood Bikdeli, Babak Sharif-Kashani, Sasan Raeissi, Solmaz Ehteshami-Afshar, Neda Behzadnia, Mohammad-Reza Masjedi. (2011) Chest physicians’ knowledge of appropriate thromboprophylaxis. Blood Coagulation & Fibrinolysis1
CrossRef21
Moshe Vardi, Lorenzo Dagna, Michal Haran, Roger Duckit. (2011) Attitudes towards and practice of venous thromboembolism prevention in general internal medicine wards. Thrombosis Research
CrossRef22
Greg Maynard, Ian Jenkins, Brian Clay, Michael Montazeri, Doug Humber. 2011. Optimizing Inpatient Anticoagulation: Strategies for Quality Improvement. , 377-414.
CrossRef23
Alex C. Spyropoulos, Charles E. Mahan. 2011. Prevention of Venous Thromboembolism in Medical Patients. , 81-106.
CrossRef24
Ho Kwok M, Litton Edward. (2011) Venous thromboembolism prophylaxis in hospitalized elderly patients: Time to consider a MUST strategy. Journal of Geriatric Cardiology 8:2, 114-120
CrossRef25
Frederic W.-B. Deleyiannis, Julio A. Clavijo-Alvarez, Benson Pullikkotil, Rami Zanoun, Tiffany Behringer, Tae W. Chong, J. Peter Rubin, Jonas T. Johnson. (2011) Development of consensus guidelines for venous thromboembolism prophylaxis in patients undergoing microvascular reconstruction of the mandible. Head & Neck 33:7, 1034-1040
CrossRef26
Markus Guzek, Olesya I. Zorina, Alexander Semmler, Roman R. Gonzenbach, Martin Huber, Gerd A. Kullak-Ublick, Michael Weller, Stefan Russmann. (2011) Evaluation of drug interactions and dosing in 484 neurological inpatients using clinical decision support software and an extended operational interaction classification system (Zurich Interaction System). Pharmacoepidemiology and Drug Safetyn/a-n/a
CrossRef27
Geert Meyfroidt, Pieter Wouters, Wilfried Becker, Dominiek Cottem, Greet Berghe. (2011) Impact of a computer-generated alert system on the quality of tight glycemic control. Intensive Care Medicine 37:7, 1151-1157
CrossRef28
R. LECUMBERRI, E. PANIZO, A. GOMEZ-GUIU, S. VAREA, E. GARCÍA-QUETGLAS, M. SERRANO, A. GARCÍA-MOURIZ, M. MARQUÉS, A. GÓMEZ-OUTES, J. A. PÁRAMO. (2011) Economic impact of an electronic alert system to prevent venous thromboembolism in hospitalised patients. Journal of Thrombosis and Haemostasis 9:6, 1108-1115
CrossRef29
Shahriar Zehtabchi, Daniel K. Nishijima, Mary Pat McKay, N. Clay Mann. (2011) Trauma Registries: History, Logistics, Limitations, and Contributions to Emergency Medicine Research. Academic Emergency Medicine 18:6, 637-643
CrossRef30
Jason D. Wright, Sharyn N. Lewin, Monjri Shah, William M. Burke, Shing M. Lee, Xuming Sun, Thomas J. Herzog. (2011) Quality of Venous Thromboembolism Prophylaxis in Patients Undergoing Oncologic Surgery. Annals of Surgery 253:6, 1140-1146
CrossRef31
Michael B. Rothberg, Peter K. Lindenauer, Maureen Lahti, Penelope S. Pekow, Harry P. Selker. (2011) Risk factor model to predict venous thromboembolism in hospitalized medical patients. Journal of Hospital Medicine 6:4, 202-209
CrossRef32
Michael J. Beck, Paul Haidet, Krista Todoric, Erik Lehman, Chris Sciamanna. (2011) Reliability of a point-based VTE risk assessment tool in the hands of medical residents. Journal of Hospital Medicine 6:4, 195-201
CrossRef33
B. D. Kent, P. Nadarajan, N. B. Akasheh, I. Sulaiman, S. Karim, S. Cooney, S. J. Lane, E. D. Moloney. (2011) Improving venous thromboembolic disease prophylaxis in medical inpatients: a role for education and audit. Irish Journal of Medical Science 180:1, 163-166
CrossRef34
Gregory Piazza, Samuel Z. Goldhaber, Darleen M. Lessard, Robert J. Goldberg, Catherine Emery, Frederick A. Spencer. (2011) Venous Thromboembolism in Heart Failure: Preventable Deaths During and After Hospitalization. The American Journal of Medicine 124:3, 252-259
CrossRef35
Michael H. Huo, Alex C. Spyropoulos. (2011) The eighth American college of chest physicians guidelines on venous thromboembolism prevention: implications for hospital prophylaxis strategies. Journal of Thrombosis and Thrombolysis 31:2, 196-208
CrossRef36
Richard J. Friedman, Sylvia Haas. (2011) Strengths and Limitations of Standards of Care to Guide the Orthopedic Surgeon in VTE Prevention. Orthopedics 34:2, 121-128
CrossRef37
Leila Ahmadian, Mariette van Engen-Verheul, Ferishta Bakhshi-Raiez, Niels Peek, Ronald Cornet, Nicolette F. de Keizer. (2011) The role of standardized data and terminological systems in computerized clinical decision support systems: Literature review and survey. International Journal of Medical Informatics 80:2, 81-93
CrossRef38
Paolo Prandoni, Khaled M Musallam, Ali T Taher. (2011) Predicting venous thromboembolism in hospitalized medical patients: are we there yet?. Expert Review of Hematology 4:1, 1-3
CrossRef39
Nicola H Chapman, Steven P Lazar, Margaret Fry, Marissa N Lassere, Beng H Chong. (2011) Clinicians adopting evidence based guidelines: a case study with thromboprophylaxis. BMC Health Services Research 11:1, 240
CrossRef40
P. E. Beeler, N. Kucher, J. Blaser. (2011) Sustained impact of electronic alerts on rate of prophylaxis against venous thromboembolism. Thrombosis and Haemostasis 106:4, 734-738
CrossRef41
C. E. Mahan, M. T. Holdsworth, S. M. Welch, M. Borrego, A. C. Spyropoulos. (2011) Deep-vein thrombosis: A United States cost model for a preventable and costly adverse event. Thrombosis and Haemostasis 106:3, 405-415
CrossRef42
Helen C. Koenig, Barbara B. Finkel, Satjeet S. Khalsa, Paul N. Lanken, Meeta Prasad, Richard Urbani, Barry D. Fuchs. (2011) Performance of an automated electronic acute lung injury screening system in intensive care unit patients*. Critical Care Medicine 39:1, 98-104
CrossRef43
Gregg Stashenko, Renato D. Lopes, David Garcia, John H. Alexander, Victor F. Tapson. (2011) Prophylaxis for venous thromboembolism: guidelines translated for the clinician. Journal of Thrombosis and Thrombolysis 31:1, 122-132
CrossRef44
Sumit R. Majumdar. (2011) Successful high-quality knowledge translation research: three case studies. Journal of Clinical Epidemiology 64:1, 21-24
CrossRef45
Nathan M Souza, Rolf J Sebaldt, Jean A Mackay, Jeanette C Prorok, Lorraine Weise-Kelly, Tamara Navarro, Nancy L Wilczynski, R Brian Haynes, . (2011) Computerized clinical decision support systems for primary preventive care: A decision-maker-researcher partnership systematic review of effects on process of care and patient outcomes. Implementation Science 6:1, 87
CrossRef46
Mrinal Dutia, Richard H. White, Ted Wun. (2011) Risk assessment models for cancer-associated venous thromboembolism. Cancern/a-n/a
CrossRef47
P. Rojnuckarin, N. Uaprasert, L. Vajragupta, N. Numkarunarunrote, N. Tanpowpong, P. Sutcharitchan. (2011) Risk factors for symptomatic venous thromboembolism in Thai hospitalised medical patients. Thrombosis and Haemostasis 106:6,
CrossRef48
G. Piazza, S. Z. Goldhaber, D. M. Lessard, R. J. Goldberg, C. Emery, F. A. Spencer. (2011) Venous thromboembolism in patients with symptomatic atherosclerosis. Thrombosis and Haemostasis 106:6,
CrossRef49
Nancy S. Lloyd, James D. Douketis, Ji Cheng, Holger J. Schünemann, Deborah J. Cook, Lehana Thabane, Menaka Pai, Frederick A. Spencer, R. Brian Haynes. (2011) Barriers and potential solutions toward optimal prophylaxis against deep vein thrombosis for hospitalized medical patients: A survey of healthcare professionals. Journal of Hospital Medicinen/a-n/a
CrossRef50
Scott M. Stevens, James D. Douketis. (2010) Deep Vein Thrombosis Prophylaxis in Hospitalized Medical Patients: Current Recommendations, General Rates of Implementation, and Initiatives for Improvement. Clinics in Chest Medicine 31:4, 675-689
CrossRef51
Kiyoaki Niimi, Masayoshi Kobayashi, Hiroshi Narita, Kiyohito Yamamoto, Kimihiro Komori. (2010) Evaluation of the efficacy of venous thromboembolism prophylaxis guideline implementation in Japan. Surgery Today 40:12, 1129-1136
CrossRef52
José Ignacio Abad Rico, Juan Vicente Llau Pitarch, José Antonio Páramo Fernández. (2010) Topical Issues in Venous Thromboembolism. Drugs 70, 11-18
CrossRef53
Andrew Friedrich. (2010) Managing Complex Systems in Perioperative Medicine. International Anesthesiology Clinics 47:4, 1-11
CrossRef54
Ursula A. Galway, Brian M. Parker, Raymond G. Borkowski. (2010) Prevention of Postoperative Surgical Site Infections. International Anesthesiology Clinics 47:4, 37-53
CrossRef55
Shaun P. Keegan, Danielle M. Patrick, Neil E. Ernst, Eric W. Mueller. (2010) Prevention of Perioperative Venous Thromboembolism. International Anesthesiology Clinics 47:4, 55-64
CrossRef56
Peter Henke. (2010) Prevention and treatment of the postthrombotic syndrome. Journal of Vascular Surgery 52:5, 21S-28S
CrossRef57
S. BARBAR, F. NOVENTA, V. ROSSETTO, A. FERRARI, B. BRANDOLIN, M. PERLATI, E. DE BON, D. TORMENE, A. PAGNAN, P. PRANDONI. (2010) A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. Journal of Thrombosis and Haemostasis 8:11, 2450-2457
CrossRef58
Elmer V. Bernstam, William R. Hersh, Ida Sim, David Eichmann, Jonathan C. Silverstein, Jack W. Smith, Michael J. Becich. (2010) Unintended consequences of health information technology: A need for biomedical informatics. Journal of Biomedical Informatics 43:5, 828-830
CrossRef59
P. Dobesh. (2010) The importance of appropriate prophylaxis for the prevention of venous thromboembolism in at-risk medical patients. International Journal of Clinical Practice 64:11, 1554-1562
CrossRef60
Raquel Barba, Antonio Zapatero, Juan E. Losa, Javier Marco, Susana Plaza, Jesús Canora, Jose Manuel Casas. (2010) Venous thromboembolism in acutely ill hospitalized medical patients. Thrombosis Research 126:4, 276-279
CrossRef61
Joseph A. Caprini. (2010) Individual Risk Assessment Is the Best Strategy for Thromboembolic Prophylaxis. Disease-a-Month 56:10, 552-559
CrossRef62
Babak Sharif-Kashani, Sasan Raeissi, Behnood Bikdeli, Payman Shahabi, Neda Behzadnia, Leila Saliminejad, Mojgan Samiei-Nejad, Fatemeh Nasiri, Maryam Khayyami, Batool Forootan, Saviz Pozhan, Mohammad-Reza Masjedi. (2010) Sticker reminders improve thromboprophylaxis appropriateness in hospitalized patients. Thrombosis Research 126:3, 211-216
CrossRef63
James Muntz. (2010) Duration of deep vein thrombosis prophylaxis in the surgical patient and its relation to quality issues. The American Journal of Surgery 200:3, 413-421
CrossRef64
Timothy K. Liem, Thanh M. Huynh, Shannon E. Moseley, Renee C. Minjarez, Gregory J. Landry, Erica L. Mitchell, Thomas G. DeLoughery, Gregory L. Moneta. (2010) Symptomatic perioperative venous thromboembolism is a frequent complication in patients with a history of deep vein thrombosis. Journal of Vascular Surgery 52:3, 651-657
CrossRef65
Joseph A Caprini. (2010) Risk assessment as a guide to thrombosis prophylaxis. Current Opinion in Pulmonary Medicine 16:5, 448-452
CrossRef66
Laura E. Butkievich, Zachary A. Stacy, Michael W. Daly, Way Y. Huey, Charles T. Taylor. (2010) Impact of a Student-Supported Pharmacy Assessment Program on Venous Thromboembolism Prophylaxis Rates in Hospitalized Patients. American Journal of Pharmaceutical Education 74:6, 105
CrossRef67
Alex C Spyropoulos. (2010) Risk assessment of venous thromboembolism in hospitalized medical patients. Current Opinion in Pulmonary Medicine 16:5, 419-425
CrossRef68
Charles E. Mahan, Mario Pini, Alex C. Spyropoulos. (2010) Venous thromboembolism prophylaxis with unfractionated heparin in the hospitalized medical patient: the case for thrice daily over twice daily dosing. Internal and Emergency Medicine 5:4, 299-306
CrossRef69
Sophie Gerkens, Ralph Crott, Marie-Christine Closon, Yves Horsmans, Claire Beguin. (2010) Comparing the quality of care across Belgian hospitals from medical basic datasets: the case of thromboembolism prophylaxis after major orthopaedic surgery. Journal of Evaluation in Clinical Practice 16:4, 685-692
CrossRef70
Marianna Dávid, Hajna Losonczy, Miklós Udvardy, Zoltán Boda, György Blaskó, Attila Tar, György Pfliegler. (2010) Vénásthromboembolia-kockázati kérdőív kórházban kezelt sebészeti és nem sebészeti betegek részére „A thromboemboliák kockázatának csökkentése és kezelése” című, 4. magyar antithromboticus irányelvben. Orvosi Hetilap 151:34, 1365-1374
CrossRef71
John Winters, David Garcia. (2010) Cancer-Associated Thrombosis. Hematology/Oncology Clinics of North America 24:4, 695-707
CrossRef72
Paul D. Stein, Fadi Matta. (2010) Acute Pulmonary Embolism. Current Problems in Cardiology 35:7, 314-376
CrossRef73
Grace D. Candelario, Charles W. Francis, Robert Panzer, Kelly S. McAdam, Diane Cockrell, Tracy Baird, Alok A. Khorana. (2010) A Computerized Prompt for Thromboprophylaxis in Hospitalized Cancer Patients. Thrombosis Research 126:1, 32-34
CrossRef74
Gregory Piazza, Samuel Z. Goldhaber. (2010) Physician alerts to prevent venous thromboembolism. Journal of Thrombosis and Thrombolysis 30:1, 1-6
CrossRef75
Diane Sliwka, Margaret C. Fang. (2010) Venous Thromboembolism Prophylaxis in the United States: Still Room for Improvement. Journal of General Internal Medicine 25:6, 484-486
CrossRef76
John Fanikos, Leslie Ann Stevens, Matthew Labreche, Gregory Piazza, Elaine Catapane, Lena Novack, Samuel Z. Goldhaber. (2010) Adherence to Pharmacological Thromboprophylaxis Orders in Hospitalized Patients. The American Journal of Medicine 123:6, 536-541
CrossRef77
Samuel Z. Goldhaber. (2010) Risk Factors for Venous Thromboembolism. Journal of the American College of Cardiology 56:1, 1-7
CrossRef78
M. R. NENDAZ, P. CHOPARD, C. LOVIS, N. KUCHER, L. M. ASMIS, J. D
RFFLER, D. SPIRK, H. BOUNAMEAUX. (2010) Adequacy of venous thromboprophylaxis in acutely ill medical patients (IMPART): multisite comparison of different clinical decision support systems. Journal of Thrombosis and Haemostasis 8:6, 1230-1234
CrossRef79
Carlos Palacio, Jeffrey P. Harrison, David Garets. (2010) Benchmarking Electronic Medical Records Initiatives in the US: a Conceptual Model. Journal of Medical Systems 34:3, 273-279
CrossRef80
Christopher J. Pannucci, Adam J. Oppenheimer, Edwin G. Wilkins. (2010) Practice Patterns in Venous Thromboembolism Prophylaxis. Annals of Plastic Surgery 64:6, 732-737
CrossRef81
M. Mandala, A. Falanga, R. Labianca. (2010) Video meliora proboque sed deteriora sequor: the case of thromboprophylaxis in hospitalized cancer patients. Annals of Oncology 21:5, 911-913
CrossRef82
Hajna Losonczy, Attila Tar. (2010) Az ENDORSE-2-HUNGARIA vizsgálat eredményei. Az akut kórházi betegek vénásthromboembolia-kockázatának és -profilaxisának ismételt hazai felmérése. Orvosi Hetilap 151:21, 843-852
CrossRef83
N. Kucher, D. Spirk, I. Baumgartner, L. Mazzolai, W. Korte, D. Nobel, M. Banyai, H. Bounameaux. (2010) Lack of prophylaxis before the onset of acute venous thromboembolism among hospitalized cancer patients: the SWIss Venous ThromboEmbolism Registry (SWIVTER). Annals of Oncology 21:5, 931-935
CrossRef84
A. Amin, A. C. Spyropoulos, P. Dobesh, A. Shorr, M. Hussein, E. Mozaffari, J. S. Benner. (2010) Are hospitals delivering appropriate VTE prevention? The venous thromboembolism study to assess the rate of thromboprophylaxis (VTE start). Journal of Thrombosis and Thrombolysis 29:3, 326-339
CrossRef85
Alexander T. Cohen, Bharathi Nandini, Jack O. Wills, Satoshi Ota. (2010) VTE prophylaxis for the medical patient: where do we stand? – A focus on cancer patients. Thrombosis Research 125, S21-S29
CrossRef86
R.M. Bauersachs, S. Haas. (2010) Thromboembolieprophylaxe in der Inneren Medizin und der hausärztlichen Versorgung. Der Internist 51:3, 314-324
CrossRef87
Sarah Jane Novis, George E. Havelka, Denise Ostrowski, Betsy Levin, Laurie Blum-Eisa, Jay B. Prystowsky, Melina R. Kibbe. (2010) Prevention of thromboembolic events in surgical patients through the creation and implementation of a computerized risk assessment program. Journal of Vascular Surgery 51:3, 648-654
CrossRef88
Dimitrios Scarvelis, Josdalyne Anderson, Laurie Davis, Melissa Forgie, James Lee, Linn Petersson, Tim Ramsay, Philip S. Wells. (2010) Hospital mortality due to pulmonary embolism and an evaluation of the usefulness of preventative interventions. Thrombosis Research 125:2, 166-170
CrossRef89
Vinita Bahl, Hsou Mei Hu, Peter K. Henke, Thomas W. Wakefield, Darrell A. Campbell, Joseph A. Caprini. (2010) A Validation Study of a Retrospective Venous Thromboembolism Risk Scoring Method. Annals of Surgery 251:2, 344-350
CrossRef90
Dale W. Bratzler. (2010) Development of national performance measures on the prevention and treatment of venous thromboembolism. Journal of Thrombosis and Thrombolysis 29:2, 148-154
CrossRef91
Silvy Laporte, Patrick Mismetti. (2010) Epidemiology of thrombotic risk factors: The difficulty in using clinical trials to develop a risk assessment model. Critical Care Medicine 38, S10-S17
CrossRef92
Greg Maynard, Jason Stein. (2010) Designing and implementing effective venous thromboembolism prevention protocols: lessons from collaborative efforts. Journal of Thrombosis and Thrombolysis 29:2, 159-166
CrossRef93
Joseph A. Caprini. (2010) Risk assessment as a guide for the prevention of the many faces of venous thromboembolism. The American Journal of Surgery 199:1, S3-S10
CrossRef94
M. BODDI, F. BARBANI, R. ABBATE, M. BONIZZOLI, S. BATACCHI, E. LUCENTE, M. CHIOSTRI, G. F. GENSINI, A. PERIS. (2010) Reduction in deep vein thrombosis incidence in intensive care after a clinician education program. Journal of Thrombosis and Haemostasis 8:1, 121-128
CrossRef95
Marc A. Passman. (2010) Mandated quality measures and economic implications of venous thromboembolism prevention and management. The American Journal of Surgery 199:1, S21-S31
CrossRef96
Jeffrey M. Riggio, Rachel Sorokin, Elizabeth D. Moxey, Paul Mather, Stuart Gould, Gregory C. Kane. (2009) Effectiveness of a Clinical-Decision-Support System in Improving Compliance With Cardiac-Care Quality Measures and Supporting Resident Training. Academic Medicine 84:12, 1719-1726
CrossRef97
Jeny George, Peter S Bernstein. (2009) Using electronic medical records to reduce errors and risks in a prenatal network. Current Opinion in Obstetrics and Gynecology 21:6, 527-531
CrossRef98
Thilo Bertsche, Vasileios Askoxylakis, Gregor Habl, Friederike Laidig, Jens Kaltschmidt, Simon P.W. Schmitt, Hamid Ghaderi, Angelika Zabel-du Bois, Stefanie Milker-Zabel, Jürgen Debus, Hubert J. Bardenheuer, Walter E. Haefeli. (2009) Multidisciplinary pain management based on a computerized clinical decision support system in cancer pain patients. PAIN 147:1-3, 20-28
CrossRef99
Biren Saraiya, Susan Goodin. (2009) Management of Venous Thromboembolism and the Potential to Impact Overall Survival in Patients with Cancer. Pharmacotherapy 29:11, 1344-1356
CrossRef100
Zeina Awar, Marwan Sheikh-Taha. (2009) Use of deep vein thrombosis prophylaxis in hospitalized cancer patients. Blood Coagulation & Fibrinolysis 20:7, 571-574
CrossRef101
David A Garcia, Jessica Highfill, Katie Finnerty, Eugene Varoz, Shawn McConkey, Keith Hutchinson, Edward Libby. (2009) A prospective, controlled trial of a pharmacy-driven alert system to increase thromboprophylaxis rates in medical inpatients. Blood Coagulation & Fibrinolysis 20:7, 541-545
CrossRef102
José A. Páramo, Ramón Lecumberri. (2009) Enfermedad tromboembólica venosa: una llamada urgente a la acción. Medicina Clínica 133:14, 547-551
CrossRef103
Franklin Michota, Patrick J. Connor, Sylvia C. McKean, Steven B. Deitelzweig, Arthur Sasahara, Anne Jacobson. (2009) Improving thromboprophylaxis: Performance measures and practical strategies. Journal of Hospital Medicine 4:S2, S24-S30
CrossRef104
Matthew C. Byrnes, Douglas J. E. Schuerer, Marilyn E. Schallom, Carrie S. Sona, John E. Mazuski, Beth E. Taylor, Wendi McKenzie, James M. Thomas, Jeffrey S. Emerson, Jennifer L. Nemeth, Ruth A. Bailey, Walter A. Boyle, Timothy G. Buchman, Craig M. Coopersmith. (2009) Implementation of a mandatory checklist of protocols and objectives improves compliance with a wide range of evidence-based intensive care unit practices. Critical Care Medicine 37:10, 2775-2781
CrossRef105
A. A. Khorana. (2009) Cancer and thrombosis: implications of published guidelines for clinical practice. Annals of Oncology 20:10, 1619-1630
CrossRef106
Alpesh N. Amin, Stephen Stemkowski, Jay Lin, Guiping Yang. (2009) Inpatient thromboprophylaxis use in U.S. hospitals: Adherence to the seventh American College of Chest Physician's recommendations for at-risk medical and surgical patients. Journal of Hospital Medicine 4:8, E15-E21
CrossRef107
S. L. COHN. (2009) Prophylaxis of venous thromboembolism in the US: improving hospital performance. Journal of Thrombosis and Haemostasis 7:9, 1437-1445
CrossRef108
Jeffrey M. Riggio, Mandelin K. Cooper, Benjamin E. Leiby, Jeanine M. Walenga, Geno J. Merli, Jonathan E. Gottlieb. (2009) Effectiveness of a clinical decision support system to identify heparin induced thrombocytopenia. Journal of Thrombosis and Thrombolysis 28:2, 124-131
CrossRef109
Paul P Dobesh. (2009) Economic Burden of Venous Thromboembolism in Hospitalized Patients. Pharmacotherapy 29:8, 943-953
CrossRef110
Andre Carlos Kajdacsy-Balla Amaral, Gordon David Rubenfeld. (2009) The future of critical care. Current Opinion in Critical Care 15:4, 308-313
CrossRef111
N. KUCHER, M. PUCK, J. BLASER, G. BUCKLAR, E. ESCHMANN, T. F. LÜSCHER. (2009) Physician compliance with advanced electronic alerts for preventing venous thromboembolism among hospitalized medical patients. Journal of Thrombosis and Haemostasis 7:8, 1291-1296
CrossRef112
Kaveh G Shojania, Alison Jennings, Alain Mayhew, Craig R Ramsay, Martin P Eccles, Jeremy Grimshaw, Kaveh G Shojania. 2009. The effects of on-screen, point of care computer reminders on processes and outcomes of care. .
CrossRef113
W. GEERTS. (2009) Prevention of venous thromboembolism: a key patient safety priority. Journal of Thrombosis and Haemostasis 7, 1-8
CrossRef114
A. C. SPYROPOULOS. (2009) Upper vs. lower extremity deep vein thrombosis: outcome definitions of venous thromboembolism for clinical predictor rules or risk factor analyses in hospitalized patients. Journal of Thrombosis and Haemostasis 7:6, 1041-1042
CrossRef115
M.E. Durán García, C. Pérez Sanz, A.B. Jiménez Muñoz, A. Giménez Manzorro, A. Muiño Miguez, L.A. Álvarez-Sala Walter, M. Sanjurjo Sáez. (2009) Intervenciones farmacoterapéuticas realizadas mediante un programa de prescripción electrónica en una unidad de medicina interna. Revista Clínica Española 209:6, 270-278
CrossRef116
José Antonio Nieto Rodríguez. (2009) Riesgo de enfermedad tromboembólica venosa y profilaxis antitrombótica en los pacientes ingresados en hospitales españoles (estudio ENDORSE). Medicina Clínica 133:1, 1-7
CrossRef117
Edward N. Libby, Agnes Y. Lee. 2009. Anticoagulants in Cancer. , 221-236.
CrossRef118
Gregg J. Stashenko, Victor F. Tapson. (2009) Prevention of venous thromboembolism in medical patients and outpatients. Nature Reviews Cardiology 6:5, 356-363
CrossRef119
Deborah Cook, Andrea Tkaczyk, Kristina Lutz, Joseph McMullin, R. Brian Haynes, James Douketis. (2009) Thromboprophylaxis for hospitalized medical patients: A Multicenter Qualitative study. Journal of Hospital Medicine 4:5, 269-275
CrossRef120
Geert Meyfroidt. (2009) How to implement information technology in the operating room and the intensive care unit. Best Practice & Research Clinical Anaesthesiology 23:1, 1-14
CrossRef121
Gregory Piazza, Samuel Z. Goldhaber. (2009) Improving Clinical Effectiveness in Thromboprophylaxis for Hospitalized Medical Patients. The American Journal of Medicine 122:3, 230-232
CrossRef122
Beverley J. Hunt. (2009) The prevention of hospital-acquired venous thromboembolism in the United Kingdom. British Journal of Haematology 144:5, 642-652
CrossRef123
Gregory A. Maynard. (2009) Medical admission order sets to improve deep vein thrombosis prevention: A model for others or a prescription for mediocrity?. Journal of Hospital Medicine 4:2, 77-80
CrossRef124
James M. Blum, Grant H. Kruger, Kathryn L. Sanders, Jorge Gutierrez, Andrew L. Rosenberg. (2009) Specificity Improvement for Network Distributed Physiologic Alarms Based on a Simple Deterministic Reactive Intelligent Agent in the Critical Care Environment. Journal of Clinical Monitoring and Computing 23:1, 21-30
CrossRef125
Tarek Hamieh, Frank Michota. (2009) Educational interventions alone are not sufficient to change outcomes in venous thromboembolism. Journal of Hospital Medicine 4:2, 142-143
CrossRef126
Marc Carrier, Agnes YY Lee. (2009) Prophylactic and therapeutic anticoagulation for thrombosis—major issues in oncology. Nature Clinical Practice Oncology 6:2, 74-84
CrossRef127
Chris O'Connor, Neill K.J. Adhikari, Katharine DeCaire, Jan O. Friedrich. (2009) Medical admission order sets to improve deep vein thrombosis prophylaxis rates and other outcomes. Journal of Hospital Medicine 4:2, 81-89
CrossRef128
Jeffrey I. Weitz. (2009) Unanswered questions in venous thromboembolism. Thrombosis Research 123, S2-S10
CrossRef129
R. Selby, W. Geerts. (2009) Prevention of venous thromboembolism: consensus, controversies, and challenges. Hematology 2009:1, 286-292
CrossRef130
N. KUCHER, D. SPIRK, C. KALKA, L. MAZZOLAI, D. NOBEL, M. BANYAI, B. FRAUCHIGER, H. BOUNAMEAUX. (2008) Clinical predictors of prophylaxis use prior to the onset of acute venous thromboembolism in hospitalized patients SWIss Venous ThromboEmbolism Registry (SWIVTER). Journal of Thrombosis and Haemostasis 6:12, 2082-2087
CrossRef131
Nicolas H. Osborne, Thomas W. Wakefield, Peter K. Henke. (2008) Venous Thromboembolism in Cancer Patients Undergoing Major Surgery. Annals of Surgical Oncology 15:12, 3567-3578
CrossRef132
Jeffrey B. Hoag. (2008) How Do You Teach an Old Dog New Tricks? Lessons from Venous Thromboembolism Prophylaxis Guidelines. Southern Medical Journal 101:12, 1195-1196
CrossRef133
Daniel P. Schauer, Anthony C. Leonard, Richard W. Hornung, Joseph A. Johnston, Mark H. Eckman. (2008) Patient-specific decision modeling to guide the use of drotrecogin α (activated) in patients with severe sepsis. Journal of Critical Care 23:4, 484-492
CrossRef134
Thomas W. Wakefield, Joseph Caprini, Anthony J. Comerota. (2008) Thromboembolic Diseases. Current Problems in Surgery 45:12, 844-899
CrossRef135
Glenn C. Shedd, Christine Franklin, Autumn M. Schumacher, Dale E. Green. (2008) Improving Inpatient Venous Thromboembolism Prophylaxis. Southern Medical Journal 101:12, 1209-1215
CrossRef136
James D Douketis. (2008) Prevention of venous thromboembolism in hospitalized medical patients: addressing some practical questions. Current Opinion in Pulmonary Medicine 14:5, 381-388
CrossRef137
Ashish Atreja, Jean-Paul Achkar, Anil K. Jain, C. Martin Harris, Bret A. Lashner. (2008) Using Technology to Promote Gastrointestinal Outcomes Research: A Case for Electronic Health Records. The American Journal of Gastroenterology 103:9, 2171-2178
CrossRef138
A Veiraiah, HGM Shetty, PA Routledge. (2008) Prevention and treatment of venous thromboembolism in older people. Reviews in Clinical Gerontology 18:03, 219
CrossRef139
Sophie Gerkens, Claire Beguin, Ralph Crott, Marie-Christine Closon, Yves Horsmans. (2008) Assessing the quality of pharmacological treatments from administrative databases: the case of low-molecular-weight heparin after major orthopaedic surgery. Journal of Evaluation in Clinical Practice 14:4, 585-594
CrossRef140
Steven R. Shackford, Frederick B. Rogers, Christopher M. Terrien, Patricia Bouchard, John Ratliff, Rebecca Zubis. (2008) A 10-year analysis of venous thromboembolism on the surgical service: The effect of practice guidelines for prophylaxis. Surgery 144:1, 3-11
CrossRef141
Lohrmann, Jens, Becker, Richard C., . (2008) New Anticoagulants — The Path from Discovery to Clinical Practice. New England Journal of Medicine 358:26, 2827-2829
Full Text142
Trevor Baglin. (2008) Venous thromboembolism in hospitalised patients: a public health crisis?. British Journal of Haematology 141:6, 764-770
CrossRef143
Aaron W. Calhoun, Gordon H. Guyatt, Michael D. Cabana, Downing Lu, David A. Turner, Stacey Valentine, Adrienne G. Randolph. (2008) Addressing the Unit of Analysis in Medical Care Studies. Medical Care 46:6, 635-643
CrossRef144
Paolo Prandoni, Michel M. Samama. (2008) Risk stratification and venous thromboprophylaxis in hospitalized medical and cancer patients. British Journal of Haematology 141:5, 587-597
CrossRef145
Gregory A. Coté, John P. Rice, William Bulsiewicz, John P. Norvell, Keri Christensen, Anne Bobb, Michael Postelnick, Colin W. Howden. (2008) Use of Physician Education and Computer Alert to Improve Targeted Use of Gastroprotection Among NSAID Users. The American Journal of Gastroenterology 103:5, 1097-1103
CrossRef146
Jürgen Graf, U. Janssens. (2008) Historie des Qualitätsmanagements. Intensivmedizin und Notfallmedizin 45:4, 171-181
CrossRef147
Steven Baroletti, Kristin Munz, Jonathan Sonis, John Fanikos, Karen Fiumara, Marilyn Paterno, Samuel Z. Goldhaber. (2008) Electronic alerts for hospitalized high-VTE risk patients not receiving prophylaxis: a cohort study. Journal of Thrombosis and Thrombolysis 25:2, 146-150
CrossRef148
Alan E. Jones, Zachary Fordham, Vasilios Yiannibas, Charles L. Johnson, Jeffrey A. Kline. (2008) Frequency of thromboprophylaxis and incidence of in-hospital venous thromboembolism in a cohort of emergency department patients. Journal of Thrombosis and Thrombolysis 25:2, 160-164
CrossRef149
Abel N. Kho, Paul R. Dexter, Jeff S. Warvel, Anne W. Belsito, Marie Commiskey, Stephen J. Wilson, Siu L. Hui, Clement J. McDonald. (2008) An effective computerized reminder for contact isolation of patients colonized or infected with resistant organisms. International Journal of Medical Informatics 77:3, 194-198
CrossRef150
Renee P. Bullock-Palmer, Steven Weiss, Charles Hyman. (2008) Innovative approaches to increase deep vein thrombosis prophylaxis rate resulting in a decrease in hospital-acquired deep vein thrombosis at a tertiary-care teaching hospital. Journal of Hospital Medicine 3:2, 148-155
CrossRef151
Saul N. Weingart, Hope E. Hamrick, Sharon Tutkus, Alexander Carbo, Daniel Z. Sands, Anjala Tess, Roger B. Davis, David W. Bates, Russell S. Phillips. (2008) Medication safety messages for patients via the web portal: The MedCheck intervention. International Journal of Medical Informatics 77:3, 161-168
CrossRef152
Walter Ageno, Francesco Dentali. (2008) Prevention of in-hospital VTE: why can't we do better?. The Lancet 371:9610, 361-362
CrossRef153
Cynthia L. Leibson, Tanya M. Petterson, Kent R. Bailey, L. Joseph Melton, John A. Heit. (2008) Risk Factors for Venous Thromboembolism in Nursing Home Residents. Mayo Clinic Proceedings 83:2, 151-157
CrossRef154
C. L. Leibson, T. M. Petterson, K. R. Bailey, L. J. Melton, J. A. Heit. (2008) Risk Factors for Venous Thromboembolism in Nursing Home Residents. Mayo Clinic Proceedings 83:2, 151-157
CrossRef155
D. Q. Pham, A. Q. Pham, E. Ullah, S. I. McFarlane, R. Payne. (2008) Evaluating the appropriateness of thromboprophylaxis in an acute care setting using a computerised reminder, through order-entry system. International Journal of Clinical Practice 62:1, 134-137
CrossRef156
Richard J. Friedman, Alexander S. Gallus, Fred D. Cushner, Gordon FitzGerald, Frederick A. Anderson. (2008) Physician compliance with guidelines for deep-vein thrombosis prevention in total hip and knee arthroplasty. Current Medical Research and Opinion 24:1, 87-97
CrossRef157
Parminder S Chaggar, Kevin S Channer. (2008) Current Issues in Thromboprophylaxis in the Elderly. Drugs & Aging 25:12, 1049-1060
CrossRef158
A. Själander, J.-H. Jansson, D. Bergqvist, H. Eriksson, B. Carlberg, P. Svensson. (2008) Efficacy and safety of anticoagulant prophylaxis to prevent venous thromboembolism in acutely ill medical inpatients: a meta-analysis. Journal of Internal Medicine 263:1, 52-60
CrossRef159
Scott M Nelson, Ian A Greer. (2007) Thromboembolic events in pregnancy: pharmacological prophylaxis and treatment. Expert Opinion on Pharmacotherapy 8:17, 2917-2931
CrossRef160
Franklin A. Michota. (2007) Bridging the Gap Between Evidence and Practice in Venous Thromboembolism Prophylaxis: The Quality Improvement Process. Journal of General Internal Medicine 22:12, 1762-1770
CrossRef161
Michael F. Mayo-Smith, Abha Agrawal. (2007) Factors associated with improved completion of computerized clinical reminders across a large healthcare system. International Journal of Medical Informatics 76:10, 710-716
CrossRef162
Mark R. Hemmila, Jill L. Jakubus, Wendy L. Wahl, Saman Arbabi, William G. Henderson, Shukri F. Khuri, Paul A. Taheri, Darrell A. Campbell. (2007) Detecting the blind spot: Complications in the trauma registry and trauma quality improvement. Surgery 142:4, 439-449
CrossRef163
Peter Henke, James Froehlich, Gilbert Upchurch, Thomas Wakefield. (2007) The Significant Negative Impact of In-Hospital Venous Thromboembolism after Cardiovascular Procedures. Annals of Vascular Surgery 21:5, 545-550
CrossRef164
Samuel Z. Goldhaber. (2007) Venous thromboembolism risk among hospitalized patients: Magnitude of the risk is staggering. American Journal of Hematology 82:9, 775-776
CrossRef165
S. Z. GOLDHABER. (2007) Preventing pulmonary embolism and deep vein thrombosis: a ?call to action? for vascular medicine specialists. Journal of Thrombosis and Haemostasis 5:8, 1607-1609
CrossRef166
A. AMIN, S. STEMKOWSKI, J. LIN, G. YANG. (2007) Thromboprophylaxis rates in US medical centers: success or failure?. Journal of Thrombosis and Haemostasis 5:8, 1610-1616
CrossRef167
Sunny Dzik. (2007) Use of a computer-assisted system for blood utilization review. Transfusion 47:s2, 142S-144S
CrossRef168
Scott M Nelson, Ian A Greer. (2007) Thrombophilia and maternal mortality: risk factors and preventive approaches. Expert Review of Obstetrics & Gynecology 2:4, 477-488
CrossRef169
Selwyn O. Rogers, Ravi K. Kilaru, Patrick Hosokawa, William G. Henderson, Michael J. Zinner, Shukri F. Khuri. (2007) Multivariable Predictors of Postoperative Venous Thromboembolic Events after General and Vascular Surgery: Results from the Patient Safety in Surgery Study. Journal of the American College of Surgeons 204:6, 1211-1221
CrossRef170
Francis, Charles W., . (2007) Prophylaxis for Thromboembolism in Hospitalized Medical Patients. New England Journal of Medicine 356:14, 1438-1444
Full Text171
D. Bergqvist. (2007) Update on In Hospital Venous Thromboembolism Prophylaxis. European Journal of Vascular and Endovascular Surgery 33:3, 343-350
CrossRef172
Sachin Kheterpal, Ruchika Gupta, James M. Blum, Kevin K. Tremper, Michael O???Reilly, Paul E. Kazanjian. (2007) Electronic Reminders Improve Procedure Documentation Compliance and Professional Fee Reimbursement. Anesthesia & Analgesia 104:3, 592-597
CrossRef173
Chethan Gangireddy, John R. Rectenwald, Gilbert R. Upchurch, Thomas W. Wakefield, Shukri Khuri, William G. Henderson, Peter K. Henke. (2007) Risk factors and clinical impact of postoperative symptomatic venous thromboembolism. Journal of Vascular Surgery 45:2, 335-342.e1
CrossRef174
Walter H. Dzik. (2007) New technology for transfusion safety. British Journal of Haematology 136:2, 181-190
CrossRef175
Susan R. Kahn, Akbar Panju, William Geerts, Graham F. Pineo, Louis Desjardins, Alexander G.G. Turpie, Stanislav Glezer, Lehana Thabane, Rolf J. Sebaldt. (2007) Multicenter evaluation of the use of venous thromboembolism prophylaxis in acutely ill medical patients in Canada. Thrombosis Research 119:2, 145-155
CrossRef176
Stephen F. Spring, Warren S. Sandberg, Shaji Anupama, John L. Walsh, William D. Driscoll, Douglas E. Raines. (2007) Automated Documentation Error Detection and Notification Improves Anesthesia Billing Performance. Anesthesiology 106:1, 157-163
CrossRef177
S. NOBOA, D. MOTTIER, E. OGER, . (2006) Estimation of a potentially preventable fraction of venous thromboembolism: a community-based prospective study. Journal of Thrombosis and Haemostasis 4:12, 2720-2722
CrossRef178
Gregory Piazza, Samuel Z. Goldhaber. (2006) Venous Thromboembolism Guidebook. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine 5:4, 211-227
CrossRef179
Jason Stein. (2006) The language of quality improvement: Therapy classes. Journal of Hospital Medicine 1:6, 327-330
CrossRef180
Steven L. Cohn, Ayoola Adekile, Vishal Mahabir. (2006) Improved use of thromboprophylaxis for deep vein thrombosis following an educational intervention. Journal of Hospital Medicine 1:6, 331-338
CrossRef181
A. FONTAINE, I. MAHÉ, J. F. BERGMANN, J. N. FIESSINGER, R. DHOTE, P. COHEN, P. VINCENEUX. (2006) Effectiveness of written guidelines on the appropriateness of thromboprophylaxis prescriptions for medical patients: a prospective randomized study. Journal of Internal Medicine 260:4, 369-376
CrossRef182
Carla M Peterman, Daniel M Kolansky, Sarah A Spinler. (2006) Prophylaxis Against Venous Thromboembolism in Acutely Ill Medical Patients: An Observational Study. Pharmacotherapy 26:8, 1086-1090
CrossRef183
J.-L. BOSSON, D. POUCHAIN, J.-F. BERGMANN, . (2006) A prospective observational study of a cohort of outpatients with an acute medical event and reduced mobility: incidence of symptomatic thromboembolism and description of thromboprophylaxis practices. Journal of Internal Medicine 260:2, 168-176
CrossRef184
Sam Schulman. (2006) Can fondaparinux safely prevent the occurrence of venous thromboembolism in acutely ill medical patients?. Nature Clinical Practice Cardiovascular Medicine 3:7, 358-359
CrossRef185
Sylvia McKean, Jason Stein, Greg Maynard, Tina Budnitz, Alpesh Amin, Scott Johnson, Larry Wellikson. (2006) Curriculum development: The venous thromboembolism quality improvement resource room. Journal of Hospital Medicine 1:2, 124-132
CrossRef186
Johann Motsch, Andreas Walther, Matthias Bock, Bernd W. B??ttiger. (2006) Update in the prevention and treatment of deep vein thrombosis and pulmonary embolism. Current Opinion in Anaesthesiology 19:1, 52-58
CrossRef187
C. Trivalle, G. Ongaro. (2006) Utilisation des héparines de bas poids moléculaire en prévention médicale par les gériatres européens. La Revue de Médecine Interne 27:1, 10-15
CrossRef188
Sylvia C. W. McKean, Tina L. Budnitz, Daniel D. Dressler, Alpesh N. Amin, Michael J. Pistoria. (2006) How to useThe Core Competencies in Hospital Medicine: A Framework for Curriculum Development. Journal of Hospital Medicine 1:1, 57-67
CrossRef189
Sylvia C. W. McKean, Tina L. Budnitz, Daniel D. Dressler, Alpesh N. Amin, Michael J. Pistoria. (2006) How to usethe core competencies in hospital medicine: A framework for curriculum development. Journal of Hospital Medicine 1:S1, 57-67
CrossRef190
Paula A. Rochon, Terry S. Field, David W. Bates, Monica Lee, Linda Gavendo, Janet Erramuspe-Mainard, James Judge, Jerry H. Gurwitz. (2005) Computerized Physician Order Entry with Clinical Decision Support in the Long-Term Care Setting: Insights from the Baycrest Centre for Geriatric Care. Journal of the American Geriatrics Society 53:10, 1780-1789
CrossRef191
Harlan M. Krumholz. (2005) The Year in Epidemiology, Health Services, and Outcomes Research. Journal of the American College of Cardiology 46:7, 1362-1370
CrossRef192
Arpana Vidyarthi, Andrew Auerbach. (2005) Is 80 the Cost of Saving Lives? Reduced Duty Hours, Errors, and Cost. Journal of General Internal Medicine 20:10, 969-970
CrossRef193
(2005) Electronic Alerts to Prevent Venous Thromboembolism. New England Journal of Medicine 352:22, 2349-2350
Full Text194
Samuel Z. Goldhaber. (2005) Venous Thromboembolism: An Ounce of Prevention. Mayo Clinic Proceedings 80:6, 725-726
CrossRef195
Durieux, Pierre, . (2005) Electronic Medical Alerts — So Simple, So Complex. New England Journal of Medicine 352:10, 1034-1036
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