Original Article
Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
N Engl J Med 2002; 346:877-883March 21, 2002DOI: 10.1056/NEJMoa013474
- Abstract
Background
Patients with reduced left ventricular function after myocardial infarction are at risk for life-threatening ventricular arrhythmias. This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients.
Methods
Over the course of four years, we enrolled 1232 patients with a prior myocardial infarction and a left ventricular ejection fraction of 0.30 or less. Patients were randomly assigned in a 3:2 ratio to receive an implantable defibrillator (742 patients) or conventional medical therapy (490 patients). Invasive electrophysiological testing for risk stratification was not required. Death from any cause was the end point.
Results
The clinical characteristics at base line and the prevalence of medication use at the time of the last follow-up visit were similar in the two treatment groups. During an average follow-up of 20 months, the mortality rates were 19.8 percent in the conventional-therapy group and 14.2 percent in the defibrillator group. The hazard ratio for the risk of death from any cause in the defibrillator group as compared with the conventional-therapy group was 0.69 (95 percent confidence interval, 0.51 to 0.93; P=0.016). The effect of defibrillator therapy on survival was similar in subgroup analyses stratified according to age, sex, ejection fraction, New York Heart Association class, and the QRS interval.
Conclusions
In patients with a prior myocardial infarction and advanced left ventricular dysfunction, prophylactic implantation of a defibrillator improves survival and should be considered as a recommended therapy.
Media in This Article
Figure 2
Kaplan–Meier Estimates of the Probability of Survival in the Group Assigned to Receive an Implantable Defibrillator and the Group Assigned to Receive Conventional Medical Therapy.Figure 1
Sequential Monitoring in the Triangular Design.Article Activity
- Article
Patients with myocardial infarction and reduced left ventricular function are at risk for congestive heart failure and arrhythmia-related sudden death. In 1996, the implantation of a defibrillator was reported to improve survival in patients with coronary heart disease, reduced ventricular function, unsustained ventricular tachycardia, and inducible ventricular tachycardia,1 and this finding was confirmed in 1999.2 In both studies, patients underwent invasive electrophysiological testing to determine their risk of arrhythmia. The prognostic value of electrophysiological testing for the identification of patients with coronary heart disease who are at risk for ventricular arrhythmias is uncertain.3 We reasoned that in patients with a prior myocardial infarction and advanced left ventricular dysfunction, the scarred myocardium would serve as a trigger for malignant ventricular arrhythmias. The Multicenter Automatic Defibrillator Implantation Trial II was designed to evaluate the potential survival benefit of a prophylactically implanted defibrillator (in the absence of electrophysiological testing to induce arrhythmias) in patients with a prior myocardial infarction and a left ventricular ejection fraction of 0.30 or less.
Methods
Organization of the Trial
The trial began on July 11, 1997, and enrolled patients from 76 hospital centers (71 in the United States and 5 in Europe). The protocol was approved by the institutional review boards of the participating hospitals. A data and safety monitoring board independently reviewed the results at regular intervals throughout the trial. All investigators agreed to abide by the conflict-of-interest guidelines described by Healy et al.4 A description of the design and study protocol has been published previously.5
Recruitment and Follow-up
Patients of either sex who were more than 21 years of age (there was no upper age limit) were eligible for the study if they had had a myocardial infarction one month or more before entry, as documented by the finding of an abnormal Q wave on electrocardiography, elevated cardiac-enzyme levels on laboratory testing during hospitalization for suspected myocardial infarction, a fixed defect on thallium scanning, or localized akinesis on ventriculography with evidence of obstructive coronary disease on angiography, and an ejection fraction of 0.30 or less within three months before entry, as assessed by angiography, radionuclide scanning, or echocardiography. Potentially eligible patients were referred by local cardiologists, internists, and primary care physicians. Patients were not required to undergo electrophysiological screening for inducible ventricular arrhythmias.
Patients were excluded from enrollment if they had an indication approved by the Food and Drug Administration (FDA) for an implantable defibrillator; were in New York Heart Association functional class IV at enrollment; had undergone coronary revascularization within the preceding three months; had had a myocardial infarction within the past month, as evidenced by measurement of cardiac-enzyme levels; had advanced cerebrovascular disease; were of childbearing age and were not using medically prescribed contraceptive measures; had any condition other than cardiac disease that was associated with a high likelihood of death during the trial; or were unwilling to sign the consent form for participation.
When the trial began in July 1997, eligible patients had to have frequent or repetitive ventricular ectopic beats during 24-hour Holter monitoring. On January 1, 1998, after the enrollment of 23 patients, the executive committee eliminated this requirement because almost all eligible patients had such arrhythmias. On May 4, 2001, the executive committee increased the enrollment goal from 1200 to 1500 patients, so that enrollment would be ongoing while data on outcomes were still accruing.
Randomization
After patients had provided written informed consent, a base-line clinical history and 12-lead electrocardiogram were obtained and a physical examination was conducted. The patients were randomly assigned in a 3:2 ratio to receive either an implantable defibrillator or conventional medical therapy. Patients who were assigned to the defibrillator group were not responsible for the costs of the defibrillator, implantation, or the hospitalization for the procedure.
Therapy
Transvenous defibrillator systems (Guidant, St. Paul, Minn.) that had been approved by the FDA were used in the trial. Standard techniques were used to implant the defibrillators. The defibrillators were tested during the implantation procedure, and every effort was made to achieve defibrillation within a 10-J safety margin. Programming the defibrillator and prescribing medications were left to the discretion of the patients' physicians. The appropriate use of beta-blockers, angiotensin-converting–enzyme inhibitors, and lipid-lowering drugs was strongly encouraged in both study groups.
Statistical Analysis
The primary end point was death from any cause. Analysis was performed according to the intention-to-treat principle. The trial was designed to have 95 percent power to detect a 38 percent reduction in the two-year mortality rate among the patients in the defibrillator group, given a postulated two-year mortality rate of 19 percent among patients assigned to conventional therapy, with a two-sided significance level of 0.05. For proportional-hazards modeling, power was maintained for a true hazard ratio of 0.63, after allowance for crossovers. We used a triangular sequential design, which was modified for two-sided alternatives6 and corrected for the lag in obtaining data accrued but not reported before the termination of the trial, for weekly monitoring, with preset boundaries to permit termination of the trial if the defibrillator therapy was found to be superior to, inferior to, or equal to conventional medical therapy. Secondary analyses were performed with use of the Cox proportional-hazards regression model.7 We determined survival curves according to the method of Kaplan and Meier,8 with comparisons of cumulative mortality based on logarithmic transformations. P values were termed nominal when they were not adjusted for sequential monitoring. All P values were two-tailed.
At the recommendation of the data and safety monitoring board the trial was stopped on November 20, 2001, shortly after an analysis revealed that the difference in mortality between the two groups had reached the prespecified efficacy boundary (P=0.027) (Figure 1Figure 1
Sequential Monitoring in the Triangular Design.). Analyses used version 2.0 of the data base, which was released on January 16, 2002. The investigators had full access to the data and performed the data analysis with no limitations imposed by the sponsor.Results
Study Population
The clinical characteristics of the 1232 randomized patients are provided in Table 1Table 1
Clinical Characteristics of the 1232 Patients.. Follow-up averaged 20 months (range, 6 days to 53 months). The base-line characteristics and the prevalence of the use of various cardiac medications at the time of the last follow-up visit were similar in the two groups. Fifty-four crossovers occurred. Twenty-two patients in the conventional-therapy group (4.5 percent) received a defibrillator during the trial, 21 for documented or suspected malignant ventricular arrhythmias and 1 at the physician's discretion. Twenty-one patients assigned to the defibrillator group (2.8 percent) did not have a defibrillator implanted, and 11 had their defibrillator removed during the trial (1.5 percent), including 9 who underwent heart transplantation. Twelve patients had their defibrillator deactivated during the trial, usually as a result of terminal illness.There were 8749 scheduled follow-up visits during the trial, with a 94 percent rate of attendance in the conventional-therapy group and a 97 percent rate in the defibrillator group. The status of three patients was not known at the termination of the trial (one patient in the conventional-therapy group and two in the defibrillator group). All three patients were known to be alive within six months before the trial ended.
Outcome
The sample path of the sequential trial is presented in Figure 1. The trajectory of the path indicates the superiority of defibrillator therapy over nondefibrillator therapy, with P=0.016 (two-sided, adjusted for the stopping rule).
The numbers of deaths in each group and the hazard ratio for death per unit of time are presented in Table 2Table 2
Hazard Ratio for Death.. The hazard ratio of 0.69 indicates a 31 percent reduction in the risk of death at any interval among patients in the defibrillator group as compared with patients in the conventional-therapy group.Kaplan-Meier estimates of survival in the two groups are shown in Figure 2Figure 2
Kaplan–Meier Estimates of the Probability of Survival in the Group Assigned to Receive an Implantable Defibrillator and the Group Assigned to Receive Conventional Medical Therapy.. The two survival curves began to diverge at approximately nine months and continued their separate paths thereafter (nominal P=0.007). These survival curves represent reductions in the rates of death after defibrillator therapy of 12 percent at one year (nominal 95 percent confidence interval, –27 to 40 percent), 28 percent at two years (nominal 95 percent confidence interval, 4 to 46 percent), and 28 percent at three years (nominal 95 percent confidence interval, 5 to 46 percent). There were no significant differences in the effect of defibrillator therapy on survival in subgroup analyses stratified according to age, sex, ejection fraction, New York Heart Association class, or the QRS interval (Figure 3Figure 3
Hazard Ratios and 95 Percent Confidence Intervals for Death from Any Cause in the Defibrillator Group as Compared with the Group Assigned to Receive Conventional Medical Therapy, According to Selected Clinical Characteristics.). There were also no significant differences in the effect of defibrillator therapy on survival in subgroup analyses classified according to the presence or absence of hypertension, diabetes, left bundle-branch block, or atrial fibrillation; the interval since the most recent myocardial infarction (six months or less vs. more than six months); the type of defibrillator implanted (single chamber vs. dual chamber); or the blood urea nitrogen level (25 mg per deciliter or less vs. more than 25 mg per deciliter).Adverse Effects
Serious complications related to defibrillator therapy were infrequent. No deaths occurred during implantation. Thirteen lead problems (1.8 percent) and five nonfatal infections (0.7 percent) required surgical intervention in the defibrillator group. The incidence of new or worsened heart failure was slightly higher in the defibrillator group than in the conventional-therapy group. Specifically, 73 patients (14.9 percent) in the conventional-therapy group and 148 in the defibrillator group (19.9 percent) were hospitalized with heart failure, representing 9.4 and 11.3 patients so hospitalized per 1000 months of active follow-up, respectively (nominal P=0.09).
Discussion
Our findings indicate that the implantation of a defibrillator improves survival among patients with a prior myocardial infarction and a left ventricular ejection fraction of 0.30 or less. As compared with conventional medical therapy, defibrillator therapy was associated with a 31 percent reduction in the risk of death. Electrophysiologic testing or inducible ventricular arrhythmias were not eligibility criteria. The two groups were balanced and received appropriate therapy with standard cardiac agents; high percentages of patients in both groups received angiotensin-converting–enzyme inhibitors, beta-blockers, diuretics, and lipid-lowering statin drugs.
In contrast with the earlier Multicenter Automatic Defibrillator Implantation Trial, in which the survival rate improved within the first few months after the implantation of the device,1 in the current study the survival benefit began approximately nine months after the device was implanted. The difference may reflect a somewhat lower mortality rate in the conventional-therapy group in the current study, the absence of risk stratification for arrhythmia as an entry criterion, the use of a lower cutoff value for the ejection fraction as a criterion for eligibility, and the use of more vigorous medical treatment. These same population differences may also explain the relatively higher hazard ratio in our study than in the earlier study (0.69 vs. 0.46).1
We are concerned by the finding that new or worsened heart failure requiring hospitalization was slightly more frequent in the defibrillator group than in the conventional-therapy group. Patients saved from malignant ventricular arrhythmias by the implantation of a defibrillator live longer than conventionally treated patients and would thus have more time for heart failure to develop. Defibrillator shocks might contribute to rehospitalization9 and myocardial injury.10 Backup ventricular pacing may impair ventricular function.11 Patients with a reduced ejection fraction who receive an implantable defibrillator should be carefully monitored for the development or exacerbation of heart failure.
An estimated 3 million to 4 million patients have coronary heart disease and advanced left ventricular dysfunction in the United States, and there are approximately 400,000 new cases annually.12,13 If a meaningful number of these patients receive an implantable defibrillator prophylactically, the cost to the health care system would be substantial. We hope that market forces will drive down the cost of this therapy.
Our findings show that the implantation of a defibrillator improves survival in patients with a prior myocardial infarction and advanced left ventricular dysfunction. Thus, prophylactic implantation of a defibrillator is recommended in these patients.
Supported by a research grant from Guidant, St. Paul, Minn., to the University of Rochester School of Medicine and Dentistry.
Drs. Cannom, Daubert, and Higgins have given lectures sponsored by Guidant.
We are indebted to the patients who participated in this trial, to the study coordinators at each of the enrolling centers, and to Guidant Corporation for its support, sustained commitment, and the independence it provided to the investigators in the conduct of this study.
Source Information
From the Cardiology Unit of the Department of Medicine (A.J.M, W.Z., J.P.D, M.W.B., M.L.A.) and the Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, N.Y.; the Division of Cardiology, University Hospital, Magdeburg, Germany (H.K.); the Cardiology Unit, Loyola University Medical Center, Maywood, Ill. (D.J.W.); Cardiology Associates, Good Samaritan Hospital, Los Angeles (D.S.C.); and the Department of Cardiology, Scripps Memorial Hospital, La Jolla, Calif. (S.L.H.).
Address reprint requests to Dr. Moss at the Heart Research Follow-up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, or at heartajm@heart.rochester.edu.
The investigators who participated in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II) are listed in the Appendix.
Appendix
The following investigators also participated in the MADIT-II (listed in descending order of the number of randomly assigned patients): Investigators — L. Berenbom, Mid-America Research Organization and University of Kansas Medical Center Research Institute, Kansas City; D. Glascock, Toledo Hospital, Toledo, Ohio; H. Klein, University Hospital Magdeburg, Magdeburg, Germany; H. Pitschner, Kerkhoff Clinic, Bad Nauheim, Germany; J. Butler, Florida Heart Association, Fort Myers; A. Leon, Crawford Long Hospital, Atlanta; J. Steinberg, St. Luke's–Roosevelt Hospital Center, New York, and Valley Hospital, Ridgewood, N.J.; S. Wittenberg, Baystate Medical Center, Springfield, Mass.; D. Switzer, Buffalo Medical Group, Buffalo, N.Y.; R. Corbisiero, Deborah Heart & Lung Center, Brown Mills, N.J.; D.J. Wilber, University of Chicago, Chicago; Northwest Community Hospital, Chicago; Loyola University Medical Center, Maywood, Ill.; W. Brodine, Kansas City Cardiology Associates, Kansas City, Kans.; D. Weiss, Florida Arrhythmia Consultants, Fort Lauderdale; A. Waldo, University Hospitals of Cleveland, Cleveland; J. Jentzer, Northeast Cardiology Associates, Bangor, Me.; M. Akhtar, Heart Care Associates, Milwaukee; K. Tucker, Orange County Heart Institute, Orange, Calif.; J. Baker, Heart Group, Nashville; D. Cannom, Good Samaritan Heart Institute, Los Angeles; C. Schuger, Henry Ford Hospital, Detroit; D. Hoch, St. Francis Hospital–Heart Center, Roslyn, N.Y.; J. Daubert, University of Rochester Medical Center, Rochester, N.Y.; M. Rashtian, Foothill Cardiology, Pasadena, Calif.; S. Higgins, Scripps Memorial Hospital, La Jolla, Calif.; G. Ziady, University of Pittsburgh Medical Center, Pittsburgh; B. Crevey, Clarian Health Methodist Hospital, Indianapolis; J. Herre, Sentara Norfolk General Hospital, Norfolk, Va.; S. Klein, Le Bauer Cardiovascular Research Foundation, Greensboro, N.C.; J. Merillat, Valley Heart Associates, Modesto, Calif.; C. Sueta, University of North Carolina, Chapel Hill; C. Kim, Rochester General Hospital, Rochester, N.Y.; S. Compton, Alaska Heart Institute, Anchorage; I. Singer, University of Louisville, Louisville, Ky.; K. Adams, Jacksonville Heart Center, Jacksonville, Fla.; J. Patterson, St. Vincent's Medical Center, Jacksonville, Fla.; M. Estes, New England Medical Center, Boston; D. Zhu, Minnesota Heart Clinic, Edina; S. Saksena, Eastern Heart Institute, Passaic, N.J.; J. Ruskin, Massachusetts General Hospital, Boston; G. Sosa-Suarez, St. Peter's Hospital, Albany, N.Y.; D. Wilkinson, Swedish Medical Center–Providence Campus, Seattle; D. Fitzgerald, Wake Forest University, Winston-Salem, N.C.; Y. Greenberg, Maimonides Medical Center, Brooklyn, N.Y.; T. Talbert, Park Ridge Medical Center, Chattanooga, Tenn.; R. Jadonath, North Shore University Hospital, Manhasset, N.Y.; J. Windle, University of Nebraska Medical Center, Omaha; L. Siddoway, York Hospital, York, Pa.; D. Borowski, Consultants in Cardiology, Inc., Erie, Pa.; E. Nsah, Peninsula Cardiology Associates, Salisbury, Md.; S. Geraci, University of Florida, Jacksonville; S. Brownstein, St. Vincent Mercy Medical Center, Toledo, Ohio; M. Schalij, Leiden University Hospital, Leiden, the Netherlands; A. Medina, Bikur Cholim Hospital, Jerusalem, Israel; E. Platia, Washington Hospital Center, Washington, D.C.; P. Friedman, Cardiovascular Specialists, Hyannis, Mass.; J. Zebede, Mount Sinai Medical Center, Miami; F. Leonelli, Cardiology Associates of Mobile, Mobile, Ala.; E.W. Grogan, Wisconsin Heart, Madison; W. Crawford, Montgomery Cardiovascular Associates, Montgomery, Ala.; D. Wattoo, Heart Center of Nevada, Las Vegas; J. Souza, Asheville Cardiology Associates, Asheville, N.C.; C. Fuenzalida, Western Cardiology Associates, Aurora, Colo.; S. Lanza, Florida Heart Group, Orlando; B. Belhassen, Tel Aviv Medical Center, Tel Aviv, Israel; R. Winkle, Sequoia Hospital, Palo Alto, Calif.; M. Illovsky, National Naval Medical Center, Bethesda, Md.; A. Dougherty, University of Texas, Houston; O. Fujimura, State University of New York Upstate Medical University, Syracuse; H. Lee, University of Iowa Health Care, Iowa City; C. Rizo-Patron, Cardiology Associates of Lubbock, Lubbock, Tex.; D. Pederson, Austin Heart, Austin, Tex.; F. Gilliam, Virginia Cardiovascular Specialists, Richmond; Data and Safety Monitoring Committee — D. Oakes (chair), T. Pearson, R. Pomerantz; End-Point Review Committee — H. Greenberg (chair), R. Case; Noninvasive Electrocardiology — W. Zareba (head), J. Palma, D. Passantino; Rochester Coordination and Data Center — M. Brown (head), M. Andrews, D. Johnsen, D. Ramsell, B. MacKecknie, A. Sorce, P. Severski, E. Carroll; Biostatisticians — W. Hall (head), V. Dragalin, P. Huang, K. Ding, C. Feng, J. Whitehead (consultant); Executive Committee — A. Moss (chair), M. Brown, D. Cannom, J. Daubert, W. Hall, S. Higgins, H. Klein, D. Wilber, W. Zareba.
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A. Proclemer, M. Ghidina, D. Gregori, D. Facchin, L. Rebellato, P. Fioretti, M. Brignole. (2008) Impact of the main implantable cardioverter-defibrillator trials in clinical practice: data from the Italian ICD Registry for the years 2005-07. Europace 11:4, 465-475
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M. Santini, M. Russo, G. Botto, M. Lunati, A. Proclemer, B. Schmidt, A. Erdogan, E. Helmling, W. Rauhe, M. Desaga, E. Santi, M. Messier, G. Boriani. (2008) Clinical and arrhythmic outcomes after implantation of a defibrillator for primary prevention of sudden death in patients with post-myocardial infarction cardiomyopathy: The Survey to Evaluate Arrhythmia Rate in High-risk MI patients (SEARCH-MI). Europace 11:4, 476-482
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RONG BAI, LUIGI DI BIASE, CLAUDE ELAYI, CHI KEONG CHING, CONOR BARRETT, KAREN PHILIPPS, PASCAL LIM, DIMPI PATEL, TOM CALLAHAN, DAVID O. MARTIN, MAURICIO ARRUDA, ROBERT A. SCHWEIKERT, WALID I. SALIBA, BRUCE WILKOFF, ANDREA NATALE. (2008) Mortality of Heart Failure Patients After Cardiac Resynchronization Therapy: Identification of Predictors. Journal of Cardiovascular Electrophysiology 19:12, 1259-1265
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Michael J. Root. (2008) Implantable Cardiac Rhythm Device Batteries. Journal of Cardiovascular Translational Research 1:4, 254-257
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Alfred P. Hallstrom, D. George Wyse, John McAnulty, . (2008) Clinical criteria for predicting benefit of ICD/PM in post myocardial infarction patients: an AVID and CAST analysis. Journal of Interventional Cardiac Electrophysiology 23:3, 159-166
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Jerry P. Nolan, Robert W. Neumar, Christophe Adrie, Mayuki Aibiki, Robert A. Berg, Bernd W. Böttiger, Clifton Callaway, Robert S.B. Clark, Romergryko G. Geocadin, Edward C. Jauch, Karl B. Kern, Ivan Laurent, W.T. Longstreth, Raina M. Merchant, Peter Morley, Laurie J. Morrison, Vinay Nadkarni, Mary Ann Peberdy, Emanuel P. Rivers, Antonio Rodriguez-Nunez, Frank W. Sellke, Christian Spaulding, Kjetil Sunde, Terry Vanden Hoek. (2008) Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication. Resuscitation 79:3, 350-379
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Ori Galante, Guy Amit, Doron Zahger, Abraham Wagshal, Reuben Ilia, Amos Katz. (2008) B-type Natruiretic Peptide Levels Stratify the Risk for Arrhythmia Among Implantable Cardioverter Defibrillator Patients. Clinical Cardiology 31:12, 586-589
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MITESH S. AMIN, AARON D. FOX, GAUTHAM KALAHASTY, RICHARD K. SHEPARD, MARK A. WOOD, KENNETH A. ELLENBOGEN. (2008) Benefit of Primary Prevention Implantable Cardioverter-Defibrillators in the Setting of Chronic Kidney Disease: A Decision Model Analysis. Journal of Cardiovascular Electrophysiology 19:12, 1275-1280
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Christian G. Wollmann, Dirk Böcker, Andreas Löher, Hans H. Scheld, Günter Breithardt, Rainer Gradaus. (2008) Diagnostik und Therapie von ICD-Elektrodendefekten. Herzschrittmachertherapie + Elektrophysiologie 19:4, 169-180
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Martin Seifert, Jana Hoffmann, Jürgen Meyhöfer, Christian Butter. (2008) Verbesserung der linksventrikulären Kontraktilität durch Stimulation in der absoluten Refraktärperiode –. Herzschrittmachertherapie + Elektrophysiologie 19:S1, 69-76
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Antonio Curnis, Giosue Mascioli, Luca Bontempi, Manuel Cerini, Tommaso Bignotti, Gabriele Bonetti, Livio Dei Cas. (2008) Is it safe to allow patients with implantable cardioverter-defibrillators to drive? Learnings from a single center experience. Journal of Cardiovascular Medicine 9:12, 1241-1245
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Alessia Gimelli, Patrizia Landi, Paolo Marraccini, Rosa Sicari, Paolo Frumento, Antonio L’Abbate, Daniele Rovai. (2008) Left ventricular ejection fraction measurements: accuracy and prognostic implications in a large population of patients with known or suspected ischemic heart disease. The International Journal of Cardiovascular Imaging 24:8, 793-801
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Lorne J. Gula, George J. Klein, Anne S. Hellkamp, David Massel, Andrew D. Krahn, Allan C. Skanes, Raymond Yee, Jill Anderson, George W. Johnson, Jeanne E. Poole, Daniel B. Mark, Kerry L. Lee, Gust H. Bardy. (2008) Ejection fraction assessment and survival: An analysis of the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). American Heart Journal 156:6, 1196-1200
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Giovanni B. Perego, Maurizio Landolina, Giuseppe Vergara, Maurizio Lunati, Gabriele Zanotto, Alessia Pappone, Gabriele Lonardi, Giancarlo Speca, Saverio Iacopino, Annamaria Varbaro, Shantanu Sarkar, Doug A. Hettrick, Alessandra Denaro, . (2008) Implantable CRT device diagnostics identify patients with increased risk for heart failure hospitalization. Journal of Interventional Cardiac Electrophysiology 23:3, 235-242
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ILAN GOLDENBERG, ARTHUR J. MOSS. (2008) Implantable Cardioverter Defibrillator Efficacy and Chronic Kidney Disease: Competing Risks of Arrhythmic and Nonarrhythmic Mortality. Journal of Cardiovascular Electrophysiology 19:12, 1281-1283
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C. A. Muratore, L. A. Batista Sa, P. A. Chiale, R. Eloy, M. C. Tentori, J. Escudero, A. M. C. Lima, L. E. Medina, R. Garillo, J. Maloney. (2008) Implantable cardioverter defibrillators and Chagas' disease: results of the ICD Registry Latin America. Europace 11:2, 164-168
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Yasushi Akutsu, Kyouichi Kaneko, Yusuke Kodama, Hui-Ling Li, Mitsuharu Kawamura, Taku Asano, Kaoru Tanno, Akira Shinozuka, Takehiko Gokan, Youichi Kobayashi. (2008) Cardiac sympathetic nerve abnormality predicts ventricular tachyarrhythmic events in patients without conventional risk of sudden death. European Journal of Nuclear Medicine and Molecular Imaging 35:11, 2066-2073
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MICHAEL O SWEENEY, ANNE S HELLKAMP, KENNETH A ELLENBOGEN, GERVASIO A LAMAS. (2008) Reduced Ejection Fraction, Sudden Cardiac Death, and Heart Failure Death in the Mode Selection Trial (MOST): Implications for Device Selection in Elderly Patients with Sinus Node Disease. Journal of Cardiovascular Electrophysiology 19:11, 1160-1166
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Theodore Chow, Dean J. Kereiakes, John Onufer, Alan Woelfel, Sinan Gursoy, Brett J. Peterson, Mark L. Brown, Wenji Pu, David G. Benditt. (2008) Does Microvolt T-Wave Alternans Testing Predict Ventricular Tachyarrhythmias in Patients With Ischemic Cardiomyopathy and Prophylactic Defibrillators?. Journal of the American College of Cardiology 52:20, 1607-1615
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FELIX YANG, BINDI SHAH, SEI IWAI, STEVEN M. MARKOWITZ, BRUCE B. LERMAN, KENNETH M. STEIN. (2008) ICD Implantation and Arrhythmia-Free Survival in Patients with Depressed LV Function Following Surgery for Valvular Heart Disease. Pacing and Clinical Electrophysiology 31:11, 1419-1424
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RITUPARNA S. SHINDE, YASH LOKHANDWALA, SUNIL V. SATHE, CHANDRASHEKAR N. MAKHALE, PURVEZ K. GRANT, MANUEL DURAIRAJ. (2008) Last Ditch CRT: Right Is Not Always Wrong!. Pacing and Clinical Electrophysiology 31:11, 1500-1502
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George Crossley, Andrew Boyle, Holly Vitense, Lou Sherfesee, R. Hardwin Mead. (2008) Trial design of the clinical evaluation of remote notification to reduce time to clinical decision: The Clinical evaluation Of remote NotificatioN to rEduCe Time to clinical decision (CONNECT) study. American Heart Journal 156:5, 840-846
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Maurizio Gasparini, Maurizio Lunati, Maurizio Landolina, Massimo Santini, Luigi Padeletti, Gianni Perego, Antonio Vincenti, Antonio Curnis, Angelo Carboni, Alessandra Denaro, Alessia Spotti, Andrea Grammatico, François Regoli, Giuseppe Boriani. (2008) Electrical storm in patients with biventricular implantable cardioverter defibrillator: Incidence, predictors, and prognostic implications. American Heart Journal 156:5, 847-854
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GIANNI PASTORE, FRANCO NOVENTA, PIERGIUSEPPE PIOVESANA, ROBERTO CAZZIN, SILVIO AGGIO, ROBERTO VERLATO, FRANCESCO ZANON, ENRICO BARACCA, LORIS RONCON, LUIGI PADELETTI, S. SERGE BAROLD. (2008) Left Ventricular Dyssynchrony Resulting from Right Ventricular Apical Pacing: Relevance of Baseline Assessment. Pacing and Clinical Electrophysiology 31:11, 1456-1462
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John P. Boehmer, Mark D. Carlson, Teresa Marco, Brian E. Jaski, Steven L. Higgins, Charles Kennergren, Andrew E. Epstein. (2008) Adjudication of mortality events in a heart failure–arrhythmia trial by a multiparameter descriptive method: Comparison with methods used in heart failure trials and methods used in arrhythmia trials. Journal of Interventional Cardiac Electrophysiology 23:2, 101-110
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Rajesh Subbiah, Lorne J. Gula, George J. Klein, Allan C. Skanes, James White, Raymond Yee, Andrew D. Krahn. (2008) Workup of the Cardiac Arrest Survivor. Progress in Cardiovascular Diseases 51:3, 195-203
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Stefan Brunner, Markus G Engelmann, Wolfgang-Michael Franz. (2008) Stem cell mobilisation for myocardial repair. Expert Opinion on Biological Therapy 8:11, 1675-1690
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Vera M.L. Gimenes, Marcelo L.C. Vieira, Mercedes M. Andrade, Jairo Pinheiro, Viviane T. Hotta, Wilson Mathias. (2008) Standard Values for Real-Time Transthoracic Three-Dimensional Echocardiographic Dyssynchrony Indexes in a Normal Population. Journal of the American Society of Echocardiography 21:11, 1229-1235
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MANISH UNDAVIA, NATHAN E. GOLDSTEIN, PILAR COHEN, KAMOLTIP SINTHAWANARONG, MAGDALENA SINGSON, DIVAYA BHUTANI, TRACEY MUNSON, JOSEPH ANTHONY GOMES, AVI FISCHER, DAVENDRA MEHTA. (2008) Impact of Implantable Cardioverter-Defibrillator Recalls on Patients' Anxiety, Depression, and Quality of Life. Pacing and Clinical Electrophysiology 31:11, 1411-1418
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Mark M. Gallagher, Giovanni B. Forleo, Elijah R. Behr, Giulia Magliano, Lucia De Luca, Valeria Morgia, Fabio De Liberato, Francesco Romeo. (2008) Prevalence and significance of Brugada-type ECG in 12,012 apparently healthy European subjects. International Journal of Cardiology 130:1, 44-48
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Margit Strauß, Anselm Kai Gitt, Torsten Becker, Thomas Kleemann, Rudolf Schiele, Harald Darius, Claus Jünger, Jochen Senges, Karlheinz Seidl, . (2008) Prehospital cardiac arrest: a marker for higher mortality in patients with acute myocardial infarction and moderately reduced left ventricular function: results from the MITRA plus registry. Clinical Research in Cardiology 97:10, 748-752
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Sana M. Al-Khatib, Gillian D. Sanders, Mark Carlson, Aida Cicic, Anne Curtis, Gregg C. Fonarow, Peter W. Groeneveld, David Hayes, Paul Heidenreich, Daniel Mark, Eric Peterson, Eric N. Prystowsky, Philip Sager, Marcel E. Salive, Kevin Thomas, Clyde W. Yancy, Wojciech Zareba, Douglas Zipes. (2008) Preventing tomorrow's sudden cardiac death today. American Heart Journal 156:4, 613-622
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Yaariv Khaykin, Allan Skanes, Bonnie Whaley, Carol Hill, Marianne Beardsall, Catherine Seabrook, Zaev Wulffhart, Richard Oosthuizen, Lorne Gula, Atul Verma. (2008) Real-time integration of 2D intracardiac echocardiography and 3D electroanatomical mapping to guide ventricular tachycardia ablation. Heart Rhythm 5:10, 1396-1402
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Saadia Sherazi, James P. Daubert, Robert C. Block, Vinodh Jeevanantham, Khalid Abdel-Gadir, Michael R. DiSalle, James M. Haley, Abrar H. Shah. (2008) Physicians' Preferences and Attitudes About End-of-Life Care in Patients With an Implantable Cardioverter-Defibrillator. Mayo Clinic Proceedings 83:10, 1139-1141
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SANA M AL-KHATIB, ANNE S. HELLKAMP, KERRY L LEE, JILL ANDERSON, JEANNE E. POOLE, DANIEL B. MARK, GUST H. BARDY, . (2008) Implantable Cardioverter Defibrillator Therapy in Patients with Prior Coronary Revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Journal of Cardiovascular Electrophysiology 19:10, 1059-1065
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Jeffrey J. Goldberger, Michael E. Cain, Stefan H. Hohnloser, Alan H. Kadish, Bradley P. Knight, Michael S. Lauer, Barry J. Maron, Richard L. Page, Rod S. Passman, David Siscovick, William G. Stevenson, Douglas P. Zipes. (2008) American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. Heart Rhythm 5:10, e1-e21
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Paul Dorian, Hussein R. Al-Khalidi, Stefan H. Hohnloser, Jose M. Brum, Preston M. Dunnmon, Craig M. Pratt, Michael J. Holroyde, Peter Kowey. (2008) Azimilide Reduces Emergency Department Visits and Hospitalizations in Patients With an Implantable Cardioverter-Defibrillator in a Placebo-Controlled Clinical Trial. Journal of the American College of Cardiology 52:13, 1076-1083
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Matthew E. Harinstein, James D. Flaherty, Gregg C. Fonarow, Mihai Gheorghiade. (2008) Directions for Research in the Post-Myocardial Infarction Patient with Left Ventricular Dysfunction. The American Journal of Cardiology 102:5, 57G-61G
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Lutz Frankenstein, Christian Zugck, Manfred Nelles, Dieter Schellberg, Andrew Remppis, Hugo Katus. (2008) Primary ICD-therapy in patients with advanced heart failure: selection strategies and future trials. Clinical Research in Cardiology 97:9, 594-600
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Suhny Abbara, Benjamin J.W. Chow, Antonio J. Pena, Ricardo C. Cury, Udo Hoffmann, Koen Nieman, Thomas J. Brady. (2008) Assessment of left ventricular function with 16- and 64-slice multi-detector computed tomography. European Journal of Radiology 67:3, 481-486
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Jeffrey J. Goldberger, Michael E. Cain, Stefan H. Hohnloser, Alan H. Kadish, Bradley P. Knight, Michael S. Lauer, Barry J. Maron, Richard L. Page, Rod S. Passman, David Siscovick, William G. Stevenson, Douglas P. Zipes. (2008) American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. Journal of the American College of Cardiology 52:14, 1179-1199
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MANINDER S. BEDI, LISA A. POSTAVA, SRINIVAS MURALI, GUY A. MACGOWAN, MICHAEL MATHIER, DENNIS M. MCNAMARA, BARRY LONDON. (2004) Interaction of Implantable Defibrillator Therapy with Angiotensin-Converting Enzyme Deletion/Insertion Polymorphism. Journal of Cardiovascular Electrophysiology 15:10, 1162-1166
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Heather M. Ross, Dusan Z. Kocovic. (2004) Cardiac resynchronization therapy for heart failure. Current Treatment Options in Cardiovascular Medicine 6:5, 365-370
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Roy M. John. (2004) Sudden cardiac death. Current Treatment Options in Cardiovascular Medicine 6:5, 347-355
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Philip B. Adamson, William T. Abraham, Charles Love, Dwight Reynolds. (2004) The evolving challenge of chronic heart failure management. Journal of the American College of Cardiology 44:7, 1354-1357
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Shrikanth P.Y. Upadya, Artyom Sedrakyan, Clara Saldarriaga, Karin Nystrom, Janis Bozzo, Forrester A. Lee, Stuart D. Katz. (2004) Comparative costs of home positive inotropic infusion versus in-hospital care in patients awaiting cardiac transplantation. Journal of Cardiac Failure 10:5, 384-389
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Abrar H. Shah, David T. Huang, Spencer Z. Rosero, James P. Daubert. (2004) Update on implantable cardioverter defibrillator trials. Current Cardiology Reports 6:5, 327-332
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ANNE B. CURTIS. (2004) Prevention of Sudden Cardiac Death:. When Is a Woman Just Like a Man?. Journal of Cardiovascular Electrophysiology 15:9, 999-1001
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Anne B. Curtis, Kenneth A. Ellenbogen, Stephen C. Hammill, David L. Hayes, Dwight W. Reynolds, David J. Wilber, Michael E. Cain. (2004) Clinical competency statement: Training pathways for implantation of cardioverter defibrillators and cardiac resynchronization devices. Heart Rhythm 1:3, 371-375
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BRUCE L. WILKOFF, MIKE HESS, JAMES YOUNG, WILLIAM T. ABRAHAM. (2004) Differences in Tachyarrhythmia Detection and Implantable Cardioverter Defibrillator Therapy by Primary or Secondary Prevention Indication in Cardiac Resynchronization Therapy Patients. Journal of Cardiovascular Electrophysiology 15:9, 1002-1009
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BRIAN F. MCBRIDE, DANETTE GUERTIN, C. MICHAEL WHITE, JEFFREY KLUGER. (2004) Inappropriate Implantable Cardioverter Defibrillator Discharge Following Consumption of a Dietary Weight Loss Supplement. Pacing and Clinical Electrophysiology 27:9, 1317-1320
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Sidney Goldstein. (2004) The changing epidemiology of sudden death in heart failure. Current Heart Failure Reports 1:3, 93-97
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ANDREA M. RUSSO, NICHOLAS J. STAMATO, MICHAEL H. LEHMANN, GAIL E. HAFLEY, KERRY L. LEE, KAREN PIEPER, ALFRED E. BUXTON, . (2004) Influence of Gender on Arrhythmia Characteristics and Outcome in the Multicenter UnSustained Tachycardia Trial. Journal of Cardiovascular Electrophysiology 15:9, 993-998
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Samuel F. Sears, Eva R. Serber, Tara Saia Lewis, Robyn L. Walker, Nancy Conners, John T. Lee, Anne B. Curtis, Jamie B. Conti. (2004) Do Positive Health Expectations and Optimism Relate to Quality-of-Life Outcomes for the Patient With an Implantable Cardioverter Defibrillator?. Journal of Cardiopulmonary Rehabilitation 24:5, 324-331
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Steven Kang, David S. Cannom. (2004) Current role of device therapy to reduce sudden cardiac death in heart failure. Current Heart Failure Reports 1:3, 104-110
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Sri Sundaram, Jeffrey J. Goldberger. (2004) Risk stratification and epidemiology of sudden death. Current Cardiology Reports 6:5, 333-338
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T.Jared Bunch, Roger D. White, Paul A. Friedman, Thomas E. Kottke, Lambert A. Wu, Douglas L. Packer. (2004) Trends in treated ventricular fibrillation out-of-hospital cardiac arrest: A 17-year population-based study. Heart Rhythm 1:3, 255-259
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Hein J.J. Wellens. (2004) Cardiac arrhythmias: The quest for a cure. Journal of the American College of Cardiology 44:6, 1155-1163
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Tomasz Siminiak, Ryszard Kalawski, Dorota Fiszer, Olga Jerzykowska, Janusz Rzeźniczak, Natalia Rozwadowska, Maciej Kurpisz. (2004) Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: Phase I clinical study with 12 months of follow-up. American Heart Journal 148:3, 531-537
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Liviu Klein, Mihai Gheorghiade. (2004) Coronary artery disease and prevention of heart failure. Medical Clinics of North America 88:5, 1209-1235
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Leonard I. Ganz. (2004) Primary prevention of sudden cardiac death. Current Cardiology Reports 6:5, 339-347
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Merritt H. Raitt. (2004) Have increasing rates of defibrillator implantation reduced the incidence of out-of-hospital cardiac arrest?. Heart Rhythm 1:3, 260-261
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Susan C. Brozena, Carol Twomey, Lee R. Goldberg, Shashank S. Desai, Brian Drachman, Andrew Kao, Eric Popjes, Ross Zimmer, Mariell Jessup. (2004) A prospective study of continuous intravenous milrinone therapy for status IB patients awaiting heart transplant at home. The Journal of Heart and Lung Transplantation 23:9, 1082-1086
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Islam Bolad, Carolyne MacLellan, Sree Karanam, Florence Parrella, Gregory Michaud, Richard D'Agostino, David Shahian, Roy John, David Martin. (2004) Effectiveness of early implantation of cardioverter defibrillator for postoperative ventricular tachyarrhythmia. The American Journal of Cardiology 94:3, 376-378
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ANDREW E. EPSTEIN. (2004) Jumping in Before the Water Is Hot:. Journal of Cardiovascular Electrophysiology 15:8, 867-869
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JOHN R. PAISEY, ARTHUR M. YUE, FREDERICK BESSOULE, STUART ALLEN, PAUL R. ROBERTS, JOHN M. MORGAN. (2004) Examination of a Middle Cardiac Vein Defibrillation Coil as Stand-Alone Anode, Auxiliary Anode, and Bystander Electrode in a Transvenous Defibrillation Circuit. Pacing and Clinical Electrophysiology 27:8, 1089-1093
1893
Béatrice Brembilla-Perrot, Christine Suty-Selton, Daniel Beurrier, Pierre Houriez, Marc Nippert, Arnaud Terrier de la Chaise, Pierre Louis, Olivier Claudon, Marius Andronache, Ahmed Abdelaah, Nicolas Sadoul, Yves Juillière. (2004) Differences in Mechanisms and Outcomes of Syncope in Patients With Coronary Disease or Idiopathic Left Ventricular Dysfunction as Assessed by Electrophysiologic Testing. Journal of the American College of Cardiology 44:3, 594-601
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VITHIDA SUEBLINVONG, MARC OVADIA. (2004) Defibrillator for Primary Prevention in Congenital Heart Disease. Pacing and Clinical Electrophysiology 27:8, 1167-1169
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LEONARD GANZ. (2004) Mechanisms of Ventricular Tachycardia Induction. Journal of Cardiovascular Electrophysiology 15:8, 908-910
1896
S SHAH. (2004) Highlights from the American College of Cardiology Annual Scientific Sessions 2004: March 9?12, 2004. American Heart Journal 148:2, 254-262
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Arthur J Moss, Anant Vyas, Henry Greenberg, Robert B Case, Wojciech Zareba, W.Jackson Hall, Mary W Brown, Scott A McNitt, Mark L Andrews. (2004) Temporal aspects of improved survival with the implanted defibrillator (MADIT-II). The American Journal of Cardiology 94:3, 312-315
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CENGIZ ERMIS, KEITH G. LURIE, ALAN X. ZHU, JOANNE COLLINS, LAURA VANHEEL, SCOTT SAKAGUCHI, FEI LU, SCOTT PHAM, DAVID G. BENDITT. (2004) Biventricular Implantable Cardioverter Defibrillators Improve Survival Compared with Biventricular Pacing Alone in Patients with Severe Left Ventricular Dysfunction. Journal of Cardiovascular Electrophysiology 15:8, 862-866
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Peter Ammann, Hanspeter Brunner-La Rocca, Thomas Fehr, Thomas M
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Olaf Hedrich, Mark Jacob, Paul J. Hauptman. (2004) Progression of coronary artery disease in non-ischemic dilated cardiomyopathy. Coronary Artery Disease 15:5, 291-297
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Peter A McCullough. (2004) Opportunities for improvement in the cardiovascular care of patients with end-stage renal disease. Advances in Chronic Kidney Disease 11:3, 294-303
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Tom D.J Smilde, Hans L Hillege, Adriaan A Voors, Peter H.J Dunselman, Dirk J van Veldhuisen. (2004) Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction. The American Journal of Cardiology 94:2, 240-243
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S.Adam Strickberger, George J Klein. (2004) Is defibrillation testing required for defibrillator implantation?. Journal of the American College of Cardiology 44:1, 88-91
1904
Amy N Solan, Merrill J Solan, Greg Bednarz, Michael B Goodkin. (2004) Treatment of patients with cardiac pacemakers and implantable cardioverter-defibrillators during radiotherapy. International Journal of Radiation Oncology*Biology*Physics 59:3, 897-904
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Rajan Krishnamani, David DeNofrio. (2004) Device therapy for the management of advanced heart failure. Expert Review of Cardiovascular Therapy 2:4, 573-580
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Julia H Indik. (2004) The evolution and revolution of the implantable cardioverter defibrillator. Expert Review of Cardiovascular Therapy 2:4, 461-464
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F. JAMES BRENNAN. (2004) Ethical Issues with Implantable Defibrillators. Pacing and Clinical Electrophysiology 27:7, 897-898
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Gerald V Naccarelli. (2004) Implantable cardioverter-defibrillators: expanding indications. Current Opinion in Cardiology 19:4, 317-322
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Alexander Berkowitsch, Wojciech Zareba, Thomas Neumann, Ali Erdogan, Scott Mc Nitt, Arthur J. Moss, Heinz F. Pitschner. (2004) Risk Stratification Using Heart Rate Turbulence and Ventricular Arrhythmia in MADIT II: Usefulness and Limitations of a 10-Minute Holter Recording. Annals of Noninvasive Electrocardiology 9:3, 270-279
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Mitchell I Cohen, Larry A Rhodes, Thomas L Spray, J.William Gaynor. (2004) Efficacy of prophylactic epicardial pacing leads in children and young adults. The Annals of Thoracic Surgery 78:1, 197-202
1911
Terrence UH Chun, Kathryn K Collins, Anne M Dubin. (2004) Implantable cardioverter defibrillators in children. Expert Review of Cardiovascular Therapy 2:4, 561-571
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Vincent Dor. (2004) Left ventricular reconstruction: The aim and the reality after twenty years. The Journal of Thoracic and Cardiovascular Surgery 128:1, 17-20
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Nanette K. Wenger, Gabriel Gregoratos, Dalane W. Kitzman, Stephen Scheidt, Michael A. Weber, Joseph S. Alpert. (2004) Guidelines of the Cardiogeriatrics Department of the Brazilian Cardiology Society: Commentary by Editorial Board Members of The American Journal of Geriatric Cardiology. CARDIAC ARRHYTHMIAS. HEART FAILURE. CORONARY ARTERY DISEASE (CHRONIC STABLE ANGINA, ACUTE CORONARY SYNDROME, ACUTE MI). SYSTEMIC ARTERIAL HYPERTENSION. VALVULOPATHIES. CARDIOVASCULAR RISK PREVENTION. The American Journal of Geriatric Cardiology 13:4, 209-209
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RAKESH K. PAI, STEVEN A. PERGAM, ANITA KEDIA, CHRISTOPHER S. CADMAN, LARRY A. OSBORN. (2004) Pacemaker Lead Infection Secondary to Haemophilus Parainfluenzae. Pacing and Clinical Electrophysiology 27:7, 1008-1010
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Harald P Kühl, Marcus Schreckenberg, Dierk Rulands, Markus Katoh, Wolfgang Schäfer, Georg Schummers, Arno Bücker, Peter Hanrath, Andreas Franke. (2004) High-resolution transthoracic real-time three-dimensional echocardiography. Journal of the American College of Cardiology 43:11, 2083-2090
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Eric D Peterson, John W Hirshfeld, T.Bruce Ferguson, Judith M Kramer, Robert M Califf, Larry G Kessler. (2004) Part II: sealing holes in the safety net. American Heart Journal 147:6, 985-990
1917
MARK H. SCHOENFELD, STEVEN J. COMPTON, R. HARDWIN MEAD, DANIEL N. WEISS, LOU SHERFESEE, JENNIFER ENGLUND, LUC R. MONGEON. (2004) Remote Monitoring of Implantable Cardioverter Defibrillators:. A Prospective Analysis. Pacing and Clinical Electrophysiology 27:6p1, 757-763
1918
George A. Diamond, Sanjay Kaul. (2004) Prior convictions. Journal of the American College of Cardiology 43:11, 1929-1939
1919
MICHAEL GLIKSON, IGOR LIPCHENCA, SAMI VISKIN, KARLA V. BALLMAN, JANE M. TRUSTY, OSNAT T. GUREVITZ, DAVID M. LURIA, MICHAEL ELDAR, STEPHEN C. HAMMILL, PAUL A. FRIEDMAN. (2004) Long-Term Outcome of Patients Who Received Implantable Cardioverter Defibrillators for Stable Ventricular Tachycardia. Journal of Cardiovascular Electrophysiology 15:6, 658-664
1920
Sarah J. Goodlin, Paul J. Hauptman, Robert Arnold, Kathleen Grady, Ray E. Hershberger, Jean Kutner, Frederick Masoudi, John Spertus, Kathleen Dracup, James F. Cleary, Ruth Medak, Kathy Crispell, Ileana piña, Brad Stuart, Christy Whitney, Thomas Rector, Joan Teno, Dale G. Renlund. (2004) Consensus statement: palliative and supportive care in advanced heart failure. Journal of Cardiac Failure 10:3, 200-209
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Gillick , Muriel R. , . (2004) Medicare Coverage for Technological Innovations — Time for New Criteria?. New England Journal of Medicine 350:21, 2199-2203
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Kadish , Alan , Dyer , Alan , Daubert , James P. , Quigg , Rebecca , Estes , N.A. Mark , Anderson , Kelley P. , Calkins , Hugh , Hoch , David , Goldberger , Jeffrey , Shalaby , Alaa , Sanders , William E. , Schaechter , Andi , Levine , Joseph H. , . (2004) Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy. New England Journal of Medicine 350:21, 2151-2158
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Bristow , Michael R. , Saxon , Leslie A. , Boehmer , John , Krueger , Steven , Kass , David A. , De Marco , Teresa , Carson , Peter , DiCarlo , Lorenzo , DeMets , David , White , Bill G. , DeVries , Dale W. , Feldman , Arthur M. , . (2004) Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure. New England Journal of Medicine 350:21, 2140-2150
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P CAWLEY. (2004) Amiodarone versus implantable cardioverter defibrillator for asymptomatic nonsustained ventricular tachycardia in nonischemic dilated cardiomyopathy. American Heart Journal 147:5, 790-791
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Andrew D Krahn, Stuart J Connolly, Robin S Roberts, Michael Gent. (2004) Diminishing proportional risk of sudden death with advancing age: implications for prevention of sudden death. American Heart Journal 147:5, 837-840
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Francois Philippon. (2004) Cardiac Resynchronization Therapy:. Device-Based Medicine for Heart Failure. Journal of Cardiac Surgery 19:3, 270-274
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ANTONIS A. ARMOUNDAS, CHRISTINE M. ALBERT, RICHARD J COHEN, THEOFANIE MELA, . (2004) Utility of Implantable Cardioverter Defibrillator Electrograms to Estimate Repolarization Alternans Preceding a Tachyarrhythmic Event. Journal of Cardiovascular Electrophysiology 15:5, 594-597
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JOSEPH JOHN and, GERALD C. KAYE. (2004) Shock Coil Failure Secondary to External Irradiation in a Patient with Implantable Cardioverter Defibrillator. Pacing and Clinical Electrophysiology 27:5, 690-691
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Tapan Rami, Hue-Teh Shih. (2004) Update of implantable cardioverter/defibrillator and cardiac resynchronization therapy in heart failure. Current Opinion in Cardiology 19:3, 264-269
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Jenny Tagney. (2004) Can nurses in cardiology areas prepare patients for implantable cardioverter defibrillator implant and life at home?. Nursing in Critical Care 9:3, 104-114
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JAMES N. WEISS, PENG-SHENG CHEN, TSU-JUEY WU, CARIN SIEGERMAN, ALAN GARFINKEL. (2004) Ventricular Fibrillation: New Insights into Mechanisms. Annals of the New York Academy of Sciences 1015:1, 122-132
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T. Jared Bunch, Roger D. White, Bernard J. Gersh, Win-Kuang Shen, Stephen C. Hammill, Douglas L. Packer. (2004) Outcomes and In-hospital Treatment of Out-of-Hospital Cardiac Arrest Patients Resuscitated From Ventricular Fibrillation by Early Defibrillation. Mayo Clinic Proceedings 79:5, 613-619
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Charles A. Herzog. (2004) Cardiac Arrest in Dialysis Patients: Taking a Small Step. Seminars in Dialysis 17:3, 184-185
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Paul A. Friedman. (2004) Will all postinfarction patients receive defibrillators? Recent trials and expanding indications. International Congress Series 1262, 360-363
1936
Henry Krum, Danny Liew. (2004) Eplerenone in the treatment of chronic heart failure. Expert Review of Cardiovascular Therapy 2:3, 315-320
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ANDREW D. KRAHN, GEORGE J. KLEIN, ALLAN C. SKANES, RAYMOND YEE. (2004) Insertable Loop Recorder Use for Detection of Intermittent Arrhythmias. Pacing and Clinical Electrophysiology 27:5, 657-664
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Irandi Jayatilleke, Alessandra Doolan, Jodie Ingles, Mark McGuire, Virginia Booth, David R. Richmond, Christopher Semsarian. (2004) Long-term follow-up of implantable cardioverter defibrillator therapy for hypertrophic cardiomyopathy. The American Journal of Cardiology 93:9, 1192-1194
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ERIC J. RASHBA. (2004) Assessment of Ventricular Repolarization Abnormalities in Congenital Long QT Syndrome. Journal of Cardiovascular Electrophysiology 15:5, 557-559
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DAVID NEWMAN, EUGENE CRYSTAL, BERNARD GOLDMAN. (2004) The Recall Genie:. Time to Go Back in the Bottle. Pacing and Clinical Electrophysiology 27:4, 435-436
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Chandra Kunavarapu, Daniel M. Bloomfield. (2004) Role of noninvasive studies in risk stratification for sudden cardiac death. Clinical Cardiology 27:4, 192-197
1942
Shrikanth Upadya, Forrester A Lee, Clara Saldarriaga, Sumit Verma, Artyom Sedrakyan, Karin Nystrom, Stuart D Katz. (2004) Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure. The Journal of Heart and Lung Transplantation 23:4, 466-472
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Henry Greenberg, Robert B. Case, Arthur J. Moss, Mary W. Brown, Elizabeth R. Carroll, Mark L. Andrews. (2004) Analysis of mortality events in the multicenter automatic defibrillator implantation trial (MADIT-II). Journal of the American College of Cardiology 43:8, 1459-1465
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Douglas P Zipes. (2004) The year in electrophysiology. Journal of the American College of Cardiology 43:7, 1306-1314
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Elena Biagini, Tjebbe W Galema, Arend F.L Schinkel, Willem B Vletter, Jos R.T.C Roelandt, Folkert J Ten Cate. (2004) Myocardial wall thickness predicts recovery of contractile function after primary coronary intervention for acute myocardial infarction. Journal of the American College of Cardiology 43:8, 1489-1493
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WILLIAM H. MAISEL. (2004) Physician Management of Pacemaker and Implantable Cardioverter Defibrillator Advisories. Pacing and Clinical Electrophysiology 27:4, 437-442
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Eldrin F. Lewis, Sui W. Tsang, James C. Fang, Gilbert H. Mudge, John A. Jarcho, Carol M. Flavell, Anju Nohria, Michael M. Givertz, Gregory S. Couper, John G. Byrne, Lynne Warner Stevenson. (2004) Frequency and impact of delayed decisions regarding heart transplantation on long-term outcomes in patients with advanced heart failure. Journal of the American College of Cardiology 43:5, 794-802
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WILLIAM J. GROH, DEEPAK BHAKTA, MIRIAM R. LOWE, SUSAN J. BENNETT. (2004) Come See the Softer Side of Clinical Outcomes:. Journal of Cardiovascular Electrophysiology 15:3, 292-294
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DAVID S. CANNOM, ERIC N. PRYSTOWSKY. (2004) The Evolution of the Implantable Cardioverter Defibrillator. Pacing and Clinical Electrophysiology 27:3, 419-431
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Javed Butler, Ghazanfar Khadim, Kimberly M. Paul, Stacy F. Davis, Marvin W. Kronenberg, Don B. Chomsky, Richard N. Pierson, John R. Wilson. (2004) Selection of patients for heart transplantationin the current era of heart failure therapy. Journal of the American College of Cardiology 43:5, 787-793
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DAVID S. CANNOM, ERIC N. PRYSTOWSKY. (2004) Evolution of the Implantable Cardioverter Defibrillator. Journal of Cardiovascular Electrophysiology 15:3, 375-385
1954
Silvia G. Priori, Leo L. Bossaert, Douglas A. Chamberlain, Carlo Napolitano, Hans R. Arntz, Rudolph W. Koster, Koen G. Monsieurs, Alessandro Capucci, Hein H. Wellens. (2004) Policy Statement. Resuscitation 60:3, 245-252
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Andrew Robert John Mitchell, Philip Anthony Roworth Spurrell, Lana Elizabeth Boodhoo, Neil Sulke. (2004) Long-term care of the patient with the atrial defibrillator. American Heart Journal 147:2, 210-217
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Ole A. Breithardt, Christoph Stellbrink. (2004) Current status of cardiac resynchronization therapy. Current Opinion in Anaesthesiology 17:1, 75-83
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Philippe Menasché. (2004) Myoblast transfer in heart failure. Surgical Clinics of North America 84:1, 125-139
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Chiara Pedone, Francesco Grigioni, Giuseppe Boriani, Carla Lofiego, Pier Luigi Vassallo, Luciano Potena, Fabio Coccolo, Gaia Magnani, Mauro Biffi, Cristian Martignani, Lorenzo Frabetti, Romano Zannoli, Carlo Magelli, Angelo Branzi. (2004) Implications of cardiac resynchronization therapy and prophylactic defibrillator implantation among patients eligible for heart transplantation. The American Journal of Cardiology 93:3, 371-373
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CARSTEN W. ISRAEL, H. STEFAN, HOHNLOSER. (2004) Electrophysiologic Refinement of Risk Stratification:. Can We Achieve the Goal?. Journal of Cardiovascular Electrophysiology 15:2, 177-178
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J. Jason Sims, Michael R. Ujhelyi. (2004) Better Living Through Medical Device Technology. Pharmacotherapy 24:2, 298-306
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Glenys A. Hamilton, Diane L. Carroll. (2004) The effects of age on quality of life in implantable cardioverter defibrillator recipients. Journal of Clinical Nursing 13:2, 194-200
1962
ERIC J. RASHBA, AHMED F. OSMAN, KAREN MACMURDY, MALCOLM M. KIRK, SAMANTHA E. SARANG, ROBERT W. PETERS, STEPHEN R. SHOROFSKY, MICHAEL R. GOLD. (2004) Enhanced Detection of Arrhythmia Vulnerability Using T Wave Alternans, Left Ventricular Ejection Fraction, and Programmed Ventricular Stimulation:. A Prospective Study in Subjects with Chronic Ischemic Heart Disease. Journal of Cardiovascular Electrophysiology 15:2, 170-176
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Dulce Obias-Manno, Mevan Wijetunga. (2004) Risk Stratification and Primary Prevention of Sudden Cardiac Death. AACN Clinical Issues: Advanced Practice in Acute and Critical Care 15:3, 404-418
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Barry D Bertolet. (2004) Precautions for Use and Adverse Effects of Vesnarinone Potential Mechanisms and Future Therapies. Drug Safety 27:Supplement 1, 11-18
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Zoran Cosic, Dragan Tavciovski, Aleksandra Jovelic, Radoslav Romanovic. (2004) Late ventricular potentials in risk assessment of the occurrence of complex ventricular arrhythmia in patients with myocardial infarction and heart failure. Vojnosanitetski pregled 61:6, 589-597
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Samuel F. Sears, Adrienne H. Kovacs, Jamie B. Conti, Eileen Handberg. (2004) Expanding the Scope of Practice for Cardiac Rehabilitation. Journal of Cardiopulmonary Rehabilitation 24:4, 209-215
1967
Julie B. Shea. (2004) Quality of Life Issues in Patients With Implantable Cardioverter Defibrillators. AACN Clinical Issues: Advanced Practice in Acute and Critical Care 15:3, 478-489
1968
Steven L. Higgins, Sharon G. O'Grady, Isabelle Banville, Fred W. Chapman, Paul W. Schmitt, Paula Lank, Robert G. Walker, Marina Ilina. (2004) E
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Rosemary S. Bubien, Elizabeth A. Ching, G. Neal Kay. (2004) Cardiac Defibrillation and Resynchronization Therapies. AACN Clinical Issues: Advanced Practice in Acute and Critical Care 15:3, 340-361
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Yoshifusa AIZAWA, Masaomi CHINUSHI, Takashi WASHIZUKA. (2004) Indications for an Implantable Cardioverter Defibrillator (ICD). Internal Medicine 43:5, 360-367
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Samuel F. Sears, Adrienne H. Kovacs, Lora Azzarello, Karin Larsen, Jamie B. Conti. (2004) Innovations in Health Psychology: The Psychosocial Care of Adults With Implantable Cardioverter Defibrillators.. Professional Psychology: Research and Practice 35:5, 520-526
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Melanie T. Gura, Lynne Foreman. (2004) Cardiac Resynchronization Therapy for Heart Failure Management. AACN Clinical Issues: Advanced Practice in Acute and Critical Care 15:3, 326-339
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John Gorcsan, Prasant Pandey, L.Elif Sade. (2004) Influence of hand-carried ultrasound on bedside patient treatment decisions for consultative cardiology. Journal of the American Society of Echocardiography 17:1, 50-55
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Andrew E. Epstein. (2004) An update on implantable cardioverter-defibrillator guidelines. Current Opinion in Cardiology 19:1, 23-25
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MARK E. ALEXANDER, FRANK CECCHIN, EDWARD P. WALSH, JOHN K. TRIEDMAN, LAURA M. BEVILACQUA, CHARLES I. BERUL. (2004) Implications of Implantable Cardioverter Defibrillator Therapy in Congenital Heart Disease and Pediatrics. Journal of Cardiovascular Electrophysiology 15:1, 72-76
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Anne B Curtis. (2004) Filling the need for new antiarrhythmic drugs to prevent shocks from implantable cardioverter defibrillators. Journal of the American College of Cardiology 43:1, 44-46
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LOU-ANNE M. BEAUREGARD. (2004) Personal Security:. Clinical Applications of the Wearable Defibrillator. Pacing and Clinical Electrophysiology 27:1, 1-3
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Julio Martí Almor, Marta Delclós Baulies, Joaquim Delclós Urgell, Josep Comín Colet, Mercè Cladellas Capdevila, Jordi Bruguera Cortada. (2004) Prevalencia y evolución en España de los pacientes con infarto agudo de miocardio y fracción de eyección severamente deprimida, con criterios de implantación de desfibrilador automático. Revista Española de Cardiología 57:7, 705-708
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Antonio Hernández Madrid, Carlos Escobar Cervantes, Blanca Blanco Tirado, Irene Marín Marín, José L. Moya Mur, Concepción Moro. (2004) Resincronización cardíaca en la insuficiencia cardíaca: bases, métodos, indicaciones y resultados. Revista Española de Cardiología 57:7, 680-693
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Julián Villacastín, Ramón Bover, Nicasio P. Castellano, Javier Moreno, Ricardo Morales, Arturo García-Espinosa. (2004) Estratificación del riesgo y prevención de la muerte súbita en pacientes con insuficiencia cardíaca. Revista Española de Cardiología 57:8, 768-782
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Philippe Menasché, Albert A Hagège, Jean-Thomas Vilquin, Michel Desnos, Eric Abergel, Bruno Pouzet, Alain Bel, Sorin Sarateanu, Marcio Scorsin, Ketty Schwartz, Patrick Bruneval, Marc Benbunan, Jean-Pierre Marolleau, Denis Duboc. (2003) Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. Journal of the American College of Cardiology 41:7, 1078-1083
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PATRICK T. ELLINOR, MARY L. GUY, JEREMY N. RUSKIN, BRIAN A. MCGOVERN. (2003) Variability in Implantable Cardioverter Defibrillator Pulse Generator Longevity Between Manufacturers. Pacing and Clinical Electrophysiology 26:1p1, 71-75
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DIRK VOLLMANN, LARS LUETHJE, DIETER ZENKER, SEBASTIAN DOMHOF, CHRISTINA UNTERBERG. (2003) Subthreshold Test Pulses Versus Low Energy Shock Delivery to Estimate High Energy Lead Impedance in Implanted Cardioverter Defibrillator Patients. Pacing and Clinical Electrophysiology 26:1p2, 457-460
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Andr
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CHRISTOPHER J. PLUMMER, R. JOHN IRVING, JANET M. MCCOMB. (2003) Implications of National Guidance for Implantable Cardioverter Defibrillation Implantation in the United Kingdom. Pacing and Clinical Electrophysiology 26:1p2, 479-482
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Rishi Arora, Daniel R. Frisch, Alan H. Kadish. The Role of Implantable Cardioverter-Defibrillators in Primary and Secondary Prevention of Sudden Cardiac Death. In: Cardiovascular Therapeutics. Elsevier, 2003:459-471.
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MAURIZIO GASPARINI, MASSIMO MANTICA, PAOLA GALIMBERTI, LUCA GENOVESE, DANIELA PINI, FRANCESCO FALETRA, UGO LA MARCHESINA, MAURIZIO MANGIAVACCHI, CATHERINE KLERSY, EDOARDO GRONDA. (2003) Is the Outcome of Cardiac Resynchronization Therapy Related to the Underlying Etiology?. Pacing and Clinical Electrophysiology 26:1p2, 175-180
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Josefa González Carrillo, Arcadi García Alberola, Daniel Saura Espín, Pilar Carrillo Sáez, Ramón López Palop, Juan J. Sánchez Muñoz, Juan Martínez Sánchez, Mariano Valdés Chávarri. (2003) Impacto de la angioplastia primaria en la indicación de desfibrilador implantable en pacientes con infarto de miocardio. Revista Española de Cardiología 56:12, 1182-1186
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Bernard J. Gersh. (2003) El pronóstico cambiante del infarto de miocardio en la era de la reperfusión: implicaciones para la evaluación y el tratamiento de las arritmias ventriculares. Revista Española de Cardiología 56:6, 535-542
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L Fauchier. (2002) Défibrillateur implantable prophylactique et stimulation biventriculaire dans l'insuffisance cardiaque. Annales de Cardiologie et d'Angéiologie 51:4, 232-237
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Marc A Pfeffer. (2002) Myocardial infarction and heart failure—a dangerous intersection. The American Journal of Medicine 113:4, 341-343
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Andreas Kliegel, Philip Eisenburger, Fritz Sterz, Michael Holzer, Heidrun Losert, Christof Havel, Günter Stix, Anton N Laggner. (2002) Survivors of ventricular tachyarrhythmias due to a transient or reversible disorder have a high recurrence rate of lethal cardiac events. Resuscitation 54:3, 237-243
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Juha S Perkiomaki, Wojciech Zareba, Henry M Greenberg, Arthur J Moss. (2002) Usefulness of standard electrocardiographic parameters for predicting cardiac events after acute myocardial infarction during modern treatment era. The American Journal of Cardiology 90:3, 205-209
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Steven L. Higgins. (2002) Automatic implantable cardiac defibrillators. Current Treatment Options in Cardiovascular Medicine 4:4, 287-293
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Eugene Crystal, Stuart J Connolly. (2002) Evolution of the implantable cardioverter defibrillator. The Lancet 359:9315, 1362-1363
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Marian A. Spath, Bernie J. O??Brien. (2002) Cost Effectiveness of Implantable Cardioverter Defibrillator Therapy versus Drug Therapy for Patients at High Risk of Sudden Cardiac Death. PharmacoEconomics 20:11, 727-738
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Jan P. Amlie, S. Bertil Olsson. (2002) Should we Implant ICDs in More Patients after Myocardial Infarction? Can we Define the Patient Groups that Benefit Most?. Scandinavian Cardiovascular Journal 36:5, 259-261
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