Original Article

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Lynn M. Boyden, Ph.D., Junhao Mao, Ph.D., Joseph Belsky, M.D., Lyle Mitzner, M.D., Anita Farhi, R.N., Mary A. Mitnick, Ph.D., Dianqing Wu, Ph.D., Karl Insogna, M.D., and Richard P. Lifton, M.D., Ph.D.

N Engl J Med 2002; 346:1513-1521May 16, 2002DOI: 10.1056/NEJMoa013444

Abstract

Background

Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis–pseudoglioma.

Full Text of Background...

Methods

We performed genetic and biochemical analyses of a kindred with an autosomal dominant syndrome characterized by high bone density, a wide and deep mandible, and torus palatinus.

Full Text of Methods...

Results

Genetic analysis revealed linkage of the syndrome to chromosome 11q12–13 (odds of linkage, >1 million to 1), an interval that contains LRP5. Affected members of the kindred had a mutation in this gene, with valine substituted for glycine at codon 171 (LRP5_V171 ). This mutation segregated with the trait in the family and was absent in control subjects. The normal glycine lies in a so-called propeller motif that is highly conserved from fruit flies to humans. Markers of bone resorption were normal in the affected subjects, whereas markers of bone formation such as osteocalcin were markedly elevated. Levels of fibronectin, a known target of signaling by Wnt, a developmental protein, were also elevated. In vitro studies showed that the normal inhibition of Wnt signaling by another protein, Dickkopf-1 (Dkk-1), was defective in the presence of LRP5_V171 and that this resulted in increased signaling due to unopposed Wnt activity.

Full Text of Results...

Conclusions

The LRP5_V171 mutation causes high bone density, with a thickened mandible and torus palatinus, by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling. These findings demonstrate the role of altered LRP5 function in high bone mass and point to Dkk as a potential target for the prevention or treatment of osteoporosis.

Full Text of Discussion...

Read the Full Article...

Media in This Article

Figure 3Mutation in LRP5.

Figure 2Pedigree of the Kindred Showing the Linkage of Bone Density to 11q12–13.

Article Activity

537 articles have cited this article

Article

Osteoporosis is a major public health problem, and its prevalence is increasing.1-3 In the United States, nearly 1 million fractures occur annually in people over the age of 65 years, the majority of which are due to osteoporosis.1,4 Osteoporotic fractures are associated with substantial morbidity, and the estimated rate of death in the first year after a hip fracture is 25 to 30 percent.5,6

Bone mass, a major determinant of the risk of osteoporotic fracture, increases during childhood and adolescence, reaching a peak at about the age of 20 years.7 Twin and family studies indicate that genetic factors account for approximately 75 percent of the variation in peak bone mass,7 although the genes that contribute to this variation are largely unknown.

In this setting, the investigation of rare mendelian disorders may identify pathways that affect the trait. One disorder characterized by increased bone density with largely normal bone is an autosomal dominant disease with variable clinical features, including entrapment neuropathies, increased levels of alkaline phosphatase, a square jaw, and torus palatinus.8-15 In 1997, Johnson et al. reported the linkage of a gene causing nonsyndromic high bone mass in a single family to a 30-cM region of 11q12–13 with a lod score of 5.74.16 Because few kindreds have been studied, the question of whether these varied clinical manifestations arise from mutations in the same gene or in different genes has not been answered.

Osteoporosis–pseudoglioma, an autosomal recessive disease characterized by low bone mass, with childhood fractures and abnormal eye development, has also been mapped to 11q12–13.17 The disorder has recently been shown to be due to an inherited loss of function of the gene for low-density lipoprotein receptor–related protein 5 (LRP5).18 This protein is involved in the Wnt signaling pathway, acting as a coreceptor for Wnt, a developmental protein, and as a target for the inhibitory effects of Dickkopf (Dkk), another developmental protein, on Wnt signaling.19-21 These findings suggest a link between Wnt signaling through LRP5 and bone density, and they raise the question of whether gain-of-function mutations in the LRP5 gene cause high bone mass. We performed genetic and biochemical analyses in a kindred with an autosomal dominant syndrome characterized by high bone density, a wide and deep mandible, and torus palatinus.

Methods

Subjects

Twenty members of a kindred of white ancestry from Connecticut participated in the study. The protocol was approved by the Human Investigation Committee at Yale University School of Medicine. All the subjects (or their guardians, in the case of minors) provided written informed consent. Assent was also obtained from minors. The subjects provided a medical history and a blood sample for DNA preparation. Bone density was measured in 16 of the 20 kindred members. The four members in whom bone density was not measured included two children (10 and 13 years old), one person who died before the study, and one person who declined to participate. We performed detailed serum and urinary biochemical measurements in four kindred members with very high bone density; these values were compared with the values in nine healthy control subjects.

Bone-Density Measurements

We measured bone mineral density in the lumbar spine, femoral neck, and total body, using dual-energy x-ray absorptiometry with a densitometer (QDR 4500W, Hologic, or DPXL, Lunar). The results are expressed as z scores (the number of standard deviations from the mean value for persons in the general population matched for age, sex, and race).

Biochemical Evaluation

Serum levels of parathyroid hormone and tartrate-resistant acid phosphatase and plasma levels of vitamin D metabolites were measured as previously reported.22,23 Serum calcium was measured with the use of flame atomic absorptiometry. Serum creatinine and phosphate levels and levels of the brain isoform of creatine kinase were measured with the use of an AutoAnalyzer (model 747-200, Hitachi) in the clinical-chemistry laboratory of Yale–New Haven Hospital in New Haven, Connecticut. Serum osteocalcin, bone-specific alkaline phosphatase, urinary N-telopeptide of type 1 collagen, the receptor for activation of nuclear factor-κB ligand, osteoprotegerin, transforming growth factor β1 (TGF-β1), and fibronectin were measured with the use of commercial kits. Mean (±SD) values in affected subjects and controls were compared with the use of unpaired two-tailed t-tests.

Genetic Studies

Polymorphic markers on 11q were genotyped with the use of a polymerase-chain-reaction (PCR) assay and specific fluorescent primers and genomic DNA from members of the kindred as the template. The products were fractionated by electrophoresis on an ABI 3700 DNA analyzer (Applied Biosystems), and genotypes were determined with the use of Genotyper software. We analyzed linkage with the use of the Linkage program, specifying high bone density as an autosomal dominant trait with a disease-allele frequency of 0.00001, complete penetrance, and a phenocopy prevalence of 0.00001. Unstudied obligate carriers were classified as “phenotype unknown.” Altering the specified model had minor effects on the lod score.

LRP5 mutations in members of the kindred were sought by PCR amplification of short segments spanning the coding region and intron–exon boundaries of LRP5; the products were analyzed by electrophoresis under nondenaturing conditions. Identified variants were subjected to DNA sequencing. The controls were 210 unrelated white persons not known to have abnormalities in bone density.

In Vitro Biochemical Studies

We used a well-characterized signaling system in the mouse fibroblast NIH3T3 cell line to examine the effect of mutant LRP5 on Wnt signaling.19 In each experiment, plasmids encoding LEF-1 (a transcription factor activated by Wnt signaling) constitutively expressed from a cytomegalovirus promoter, luciferase under control of an LEF-1–responsive promoter, and green fluorescent protein were introduced by transfection into cells seeded in 24-well plates. In addition, plasmids encoding wild-type (normal) LRP5 or LRP5_V171, Wnt-1, and Dkk type 1 (Dkk-1) were transfected in indicated combinations. The total amount of DNA transfected in each experiment was kept constant (0.5 μg per well) by the addition of varying amounts of a plasmid encoding β-galactosidase (LacZ). One day after transfection, the cells were lysed, and the levels of luciferase activity and green fluorescent protein were measured; luciferase activity was normalized according to the green fluorescent protein level in order to account for variation in the efficiency of transfection. Each experiment was conducted in triplicate. Values are reported as means ±SD.

Results

Identification of the Kindred

The kindred was identified when two persons found on clinical screening to have extremely high bone density (Subjects 3 and 6) were incidentally noted to be related to one another. In addition to high bone density, both had a strikingly wide and deep mandible (Figure 1AFigure 1Clinical and Radiographic Features of Affected Members of the Kindred. and Figure 1B) and torus palatinus (Figure 1C). Radiographic studies showed normal skeletal morphology except for dramatically thickened mandibular ramii (Figure 1D), marked cortical thickening in long bones (Figure 1E), and dense vertebrae (Figure 1F). There was no radiographic evidence of osteopetrosis, and the shape of the vertebral bodies was normal. There were no cranial-nerve palsies. Both persons were asymptomatic but noted difficulty staying afloat while swimming. They reported that other family members had the same facial features, prompting an investigation of the kindred.

Bone Density

A total of seven members of the kindred had strikingly elevated age- and sex-adjusted bone mineral density in the lumbar spine, femoral neck, and total body, whereas nine had normal bone density at all sites (Table 1Table 1Clinical Phenotypes in the Kindred.). Phenotypic classification of bone density as either very high (indicating affected subjects) or normal (indicating unaffected subjects) was unambiguous. In affected subjects, age- and sex-adjusted bone density of the lumbar spine was at least 5 SD above the population mean, and the mean z scores for bone density in the lumbar spine, femoral neck, and total body were 6.83, 4.42, and 4.78, respectively. In contrast, none of the unaffected subjects had a z score at any site that was greater than 2.71, and the mean z scores for bone density in the lumbar spine, femoral neck, and total body were 0.40, –0.61, and –0.08, respectively. All affected subjects had torus palatinus and the striking square jaw; none of the unaffected subjects had either of these features. None of the affected subjects had a history of bone fracture.

The pattern of elevated bone density with torus palatinus and a square jaw was characteristic of autosomal dominant transmission with high penetrance (Figure 2Figure 2Pedigree of the Kindred Showing the Linkage of Bone Density to 11q12–13.). The trait was present in successive generations, affected or obligate-carrier parents had approximately equal numbers of affected and unaffected offspring overall, and there was male-to-male transmission. There were four deceased obligate gene carriers, one of whom (Subject 16) was examined before death and found to have torus palatinus and the characteristic mandible. Three living family members (Subjects 17, 18, and 19) did not undergo bone-density measurements, but they did not have torus palatinus or the characteristic facies.

Biochemical Findings

The mean serum calcium and phosphate levels were normal in the affected subjects; the urinary calcium level was at the high end of the normal range (Table 2Table 2Indexes of Mineral Metabolism and Markers of Bone Turnover in Four Affected Subjects and Nine Controls.). Serum levels of parathyroid hormone and vitamin D metabolites were also normal. In addition, the mean serum level of tartrate-resistant acid phosphatase was normal (1.2±2 U per liter), and serum levels of the brain isoform of creatine kinase were undetectable; these two biochemical markers may be elevated in patients with osteopetrosis.24,25

The mean level of urinary N-telopeptide of type 1 collagen, a marker of bone resorption, was normal in the affected subjects (Table 2). Circulating levels of the receptor for activation of nuclear factor-κB ligand and osteoprotegerin, cytokines that regulate rates of bone resorption,26 were also normal. As noted above, the level of tartrate-resistant acid phosphatase, a marker of osteoclast activity, was normal. In contrast, the mean level of serum osteocalcin, a marker of bone formation, was markedly elevated — more than three times the value in the controls. The values for bone-specific alkaline phosphatase were not elevated in the affected subjects (mean value, 25±6 U per liter; normal range, 15 to 41). The levels of TGF-β1 were markedly elevated. These findings suggested that increased bone formation with unaltered bone resorption was the mechanism of high bone density in affected members of this family.

Point Mutation in LRP5

Because of prior reports of linkage of both high-bone-density and low-bone-density phenotypes to 11q12–13,16,17,27,28 we performed genotyping for 37 polymorphic genetic markers across a 40-cM segment of this interval (Figure 2). Analysis of the relation between inheritance of this chromosome segment and high bone density provided strong evidence of linkage, with a multipoint lod score of 5.30. When the three subjects in whom bone density was not measured but who did not have torus palatinus or a square jaw were included in the analysis as unaffected subjects, the lod score was 6.21 (odds of linkage to 11q12–13, >1 million to 1). Meiotic recombination events in affected subjects localized the disease gene to the 16-cM interval flanked by loci D11S4191 and D11S4207. This linked interval contains LRP5, the gene for osteoporosis–pseudoglioma.18

The protein encoded by LRP5 spans the plasma membrane once and contains a large extracellular segment with four domains that are each predicted to form a structure resembling a propeller with six blades (Figure 3AFigure 3Mutation in LRP5.). The amino acid sequence YWTD or a variant of this sequence is found as a conserved element (a YWTD repeat) in each propeller blade.29,30

We examined the coding sequence of LRP5 for DNA-sequence variants and identified one variant in all the affected subjects (Figure 3B). This variant introduced a single base substitution that resulted in a missense mutation, with valine substituted for glycine at residue 171 (LRP5_V171) (Figure 3C). The residue lies in the fourth blade of the first propeller, two amino acids beyond the aspartate residue of the YWTD sequence (Figure 3A and Figure 3D).

The heterozygous LRP5_V171 mutation precisely cosegregated with high bone density in the kindred (Figure 3B); LRP5_V171 is not a simple polymorphism, since it was absent in 420 control chromosomes from unrelated, unaffected subjects. The normal glycine residue shows extraordinary evolutionary conservation (Figure 3D). Glycine is found at the same position in the fourth blade of the first three propellers of LRP5 and LRP6 in humans and mice, as well as in the single propeller of the low-density lipoprotein (LDL) receptor in humans, mice, rats, pigs, hamsters, and rabbits. Moreover, glycine is also found at this position in the first propeller of the Drosophila melanogaster LDL-receptor–related protein homologue, arrow. In addition, glycine is present at this position in a wide range of other YWTD propellers, including those in other LDL-receptor–related proteins, as well as those in the epidermal growth factor precursor, the very-low-density lipoprotein receptor, and the vitellogenin receptor in fruit flies and mosquitos (protein sequences are available at http://www.ncbi.nlm.nih.gov/entrez). The evolutionary conservation of this glycine residue is strong evidence of the functional importance of its mutation in our kindred.

Molecular Studies

If this mutation indeed causes gain of LRP5 function and increased Wnt signaling, downstream target genes in the Wnt signaling pathway should show increased expression in vivo. A direct transcriptional target of Wnt signaling is the extracellular matrix protein fibronectin.31 Fibronectin levels were markedly elevated in the affected members of our kindred, with a mean level that was more than 3 SD above the mean level in controls (Table 2).

Possible mechanisms of increased Wnt signaling include constitutive signaling in the absence of a ligand, increased signaling in response to a ligand, or loss of action of a normal inhibitor of signaling. To identify the mechanism, we performed in vitro studies using the mouse fibroblast NIH3T3 cell line, in which the expression of normal LRP5 potentiates Wnt signaling.19 We found that the expression of LRP5_V171 did not activate signaling in the absence of Wnt-1, a finding that ruled out constitutive signaling as the mechanism (Figure 4AFigure 4Level of Wnt Signaling with Normal and Mutant LRP5.). Activation of the signaling pathway in response to Wnt-1 was the same with normal and mutant LRP5; this finding ruled out increased activation by a ligand as the mechanism (Figure 4A). Finally, we tested the action of the endogenous antagonist of Wnt signaling, Dkk-1. Although Dkk-1 inhibited Wnt signaling in conjunction with wild-type LRP5, Dkk-1 inhibition of Wnt signaling was virtually abolished in cells expressing LRP5_V171 (Figure 4B). These findings indicated that LRP5_V171 results in increased Wnt signaling because of loss of Dkk antagonism.

Discussion

Recent work has established that loss of function of LRP5 leads to reduced bone mass.18 Our study shows that a gain-of-function mutation in LRP5 causes an autosomal dominant disorder characterized by high bone density, torus palatinus, and a wide, deep mandible.

Our in vitro and in vivo studies show that the LRP5_V171 mutation increases Wnt signaling. The mutation impairs antagonism of Wnt signaling by Dkk-1 in vitro, and the levels of fibronectin, a downstream target of Wnt signaling, are increased in vivo in patients with this mutation. These findings indicate that unopposed Wnt signaling due to loss of action of a normal antagonist is the molecular mechanism that accounts for the effect of the mutation.

Nonsyndromic high bone mass has been linked to 11q12–13 in another kindred.16 While we were preparing this report, Little et al. identified an LRP5 mutation in the other kindred.32 Remarkably, this mutation is identical to the LRP5_V171 mutation in our kindred. To our knowledge, these families do not share a common ancestor, suggesting that the mutations have arisen independently; however, the possibility of a very remote common ancestor cannot be excluded. It is striking that the same mutation is associated with nonsyndromic high bone mass in one family and syndromic high bone mass in the other. These findings suggest that alleles of other genes or environmental factors influence phenotypic manifestations of the mutation and that other phenotypes in kindreds with autosomal dominant high bone mass may also arise from the same mutation. If this is correct, all these disorders could be diagnosed with the use of a simple genetic test. The findings also suggest that the target for gain-of-function mutations in LRP5 is very small, possibly indicating a site critical for Dkk binding or action.

Our findings provide evidence that the Wnt signaling pathway alters bone mass through a primary effect on bone formation. Biochemical markers of bone resorption were unaltered in affected members of our kindred, whereas levels of specific markers of osteoblast activity were strikingly elevated. These findings indicate an uncoupling of bone turnover in favor of increased bone formation. The observation that LRP5 is expressed at high levels in osteoblasts is consistent with its having a role in this axis.33 The elevated fibronectin levels are also consistent with an effect on bone formation, since fibronectin is an early scaffolding protein in osteoid formation and enhances the survival and differentiation of osteoblasts.34-37 Finally, the observed elevation in TGF-β1 levels is noteworthy. TGF-β1 has stimulatory effects on osteoblasts, and targeted disruption in mice results in reduced bone mass.38-40

Given the established role of rare LRP5 mutations in abnormal bone density, it is of particular interest that variation in bone density in the general population may be linked to the chromosome segment containing LRP5.28 This finding raises the possibility that common variants that alter the expression or function of LRP5 will be found to have a role in the risk of osteoporosis in the general population. Further studies will be required to investigate this possibility. Finally, the observation that the impaired action of Dkk at LRP5 increases bone density suggests that pharmacologic antagonism of Dkk action, either at the prereceptor level or through the inhibition of binding or action at LRP5, may have a role in the prevention or treatment of osteoporosis.

Supported by grants from the National Institutes of Health (AG15345, to Dr. Insogna, and CA85420, to Dr. Wu), the Danbury Hospital Medical Education Center, the Yale Core Center for Musculoskeletal Disorders (AR46032, to Dr. Insogna), the Yale Bone Center, and the Yale General Clinical Research Center (National Center for Research Resources grant RR00125). Dr. Lifton is an Investigator of the Howard Hughes Medical Institute.

We are indebted to the members of the kindred who participated in the study for making this work possible, and to Carol Nelson-Williams, Ana Quinones, Diane Wall, and the staff of the Yale General Clinical Research Center, for technical assistance and helpful discussions.

Source Information

From the Departments of Genetics (L.M.B., A.F., R.P.L.) and Medicine (J.B., L.M., M.A.M., K.I., R.P.L.), Yale University School of Medicine, New Haven; and the Department of Genetics and Developmental Biology (J.M., D.W.), University of Connecticut Health Center, Farmington — both in Connecticut.

Address reprint requests to Dr. Lifton at the Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., New Haven, CT 06510, or at richard.lifton@yale.edu.

References

References

1. 1

   NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001;285:785-795
   CrossRef | Web of Science

2. 2

   Lips P. Epidemiology and predictors of fractures associated with osteoporosis. Am J Med 1997;103:Suppl:3S-8S
   CrossRef | Medline

3. 3

   Kannus P, Palvanen M, Niemi S, Parkkari J, Jarvinen M. Epidemiology of osteoporotic pelvic fractures in elderly people in Finland: sharp increase in 1970-1997 and alarming projections for the new millennium. Osteoporos Int 2000;11:443-448
   CrossRef | Web of Science | Medline

4. 4

   Incidence and costs to Medicare of fractures among Medicare beneficiaries aged ≥65 years -- United States, July 1991-June 1992. MMWR Morb Mortal Wkly Rep 1996;45:877-883
   Medline

5. 5

   Zuckerman JD. Hip fracture. N Engl J Med 1996;334:1519-1525
   Full Text | Web of Science | Medline

6. 6

   Poor G, Atkinson EJ, O'Fallon WM, Melton LJ. Determinants of reduced survival following hip fractures in men. Clin Orthop 1995;319:260-265
   Web of Science | Medline

7. 7

   Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int 2000;11:985-1009
   CrossRef | Web of Science | Medline

8. 8

   Worth HM, Wollin DG. Hyperostosis coticalis generalisata congenita. J Can Assoc Radiol 1966;17:67-74
   Medline

9. 9

   Russell WJ, Bizzozero OJ Jr, Omori Y. Idiopathic osteosclerosis: a report of 6 related cases. Radiology 1968;90:70-76
   Web of Science | Medline

10. 10

    Maroteaux P, Fontaine G, Scharfman W, Farriaux JP. L'hyperostose corticale generalisee a transmission dominante (type Worth). Arch Fr Pediatr 1971;28:685-698
    Medline

11. 11

    Owen RH. Van Buchem's disease (Hyperostosis corticalis generalisata). Br J Radiol 1976;49:126-132
    CrossRef | Web of Science | Medline

12. 12

    Gelman MI. Autosomal dominant osteosclerosis. Radiology 1977;125:289-296
    Web of Science | Medline

13. 13

    Gorlin RJ, Glass L. Autosomal dominant osteosclerosis. Radiology 1977;125:547-548
    Web of Science | Medline

14. 14

    Perez-Vicente JA, Rodriguez de Castro E, Lafuente J, Mateo MMD, Gimenez-Roldan S. Autosomal dominant endosteal hyperostosis: report of a Spanish family with neurological involvement. Clin Genet 1987;31:161-169
    CrossRef | Web of Science | Medline

15. 15

    Ades LC, Morris LL, Burns R, Haan EA. Neurological involvement in Worth type endosteal hyperostosis: report of a family. Am J Med Genet 1994;51:46-50
    CrossRef | Web of Science | Medline

16. 16

    Johnson ML, Gong G, Kimberling W, Recker SM, Kimmel DB, Recker RB. Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13). Am J Hum Genet 1997;60:1326-1332
    CrossRef | Web of Science | Medline

17. 17

    Gong Y, Vikkula M, Boon L, et al. Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet 1996;59:146-151
    Web of Science | Medline

18. 18

    Gong Y, Slee RB, Fukai N, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001;107:513-523
    CrossRef | Web of Science | Medline

19. 19

    Mao J, Wang J, Liu B, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001;7:801-809
    CrossRef | Web of Science | Medline

20. 20

    Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 2001;11:951-961
    CrossRef | Web of Science | Medline

21. 21

    Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 2001;3:683-686
    CrossRef | Web of Science | Medline

22. 22

    Kerstetter JE, Caseria DM, Mitnick ME, et al. Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet. Am J Clin Nutr 1997;66:1188-1196
    Web of Science | Medline

23. 23

    Meric F, Yap P, Bia MJ. Etiology of hypercalcemia in hemodialysis patients on calcium carbonate therapy. Am J Kidney Dis 1990;16:459-464
    Web of Science | Medline

24. 24

    Whyte MP, Chines A, Silva DP Jr, Landt Y, Ladenson JH. Creatine kinase brain isoenzyme (BB-CK) presence in serum distinguishes osteopetroses among the sclerosing bone disorders. J Bone Miner Res 1996;11:1438-1443
    CrossRef | Web of Science | Medline

25. 25

    Takacs I, Cooper H, Weaver DD, Econs MJ. Bone mineral density and laboratory evaluation of a type II autosomal dominant osteopetrosis carrier. Am J Med Genet 1999;85:9-12
    CrossRef | Web of Science | Medline

26. 26

    Teitelbaum SL. Bone resorption by osteoclasts. Science 2000;289:1504-1508
    CrossRef | Web of Science | Medline

27. 27

    Heaney C, Shalev H, Elbedour K, et al. Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. Hum Mol Genet 1998;7:1407-1410
    CrossRef | Web of Science | Medline

28. 28

    Koller DL, Rodriguez LA, Christian JC, et al. Linkage of a QTL contributing to normal variation in bone mineral density to chromosome 11q12-13. J Bone Miner Res 1998;13:1903-1908
    CrossRef | Web of Science | Medline

29. 29

    Springer TA. An extracellular β-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. J Mol Biol 1998;283:837-862
    CrossRef | Web of Science | Medline

30. 30

    Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat Struct Biol 2001;8:499-504
    CrossRef | Medline

31. 31

    Gradl D, Kuhl M, Wedlich D. The Wnt/Wg signal transducer β-catenin controls fibronectin expression. Mol Cell Biol 1999;19:5576-5587
    Web of Science | Medline

32. 32

    Little RD, Carulli JP, Del Mastro RG, et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 2002;70:11-19
    CrossRef | Web of Science | Medline

33. 33

    Dong Y, Lathrop W, Weaver D, et al. Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem Biophys Res Commun 1998;251:784-790
    CrossRef | Web of Science | Medline

34. 34

    Eielson C, Kaplan D, Mitnick MA, Paliwal I, Insogna K. Estrogen modulates parathyroid hormone-induced fibronectin production in human and rat osteoblast-like cells. Endocrinology 1994;135:1639-1644
    CrossRef | Web of Science | Medline

35. 35

    Sun BH, Mitnick M, Eielson C, Yao GQ, Paliwal I, Insogna K. Parathyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy. Endocrinology 1997;138:3918-3924
    CrossRef | Web of Science | Medline

36. 36

    Globus RK, Doty SB, Lull JC, Holmuhamedov E, Humphries MJ, Damsky CH. Fibronectin is a survival factor for differentiated osteoblasts. J Cell Sci 1998;111:1385-1393
    Web of Science | Medline

37. 37

    Moursi AM, Damsky CH, Lull J, et al. Fibronectin regulates calvarial osteoblast differentiation. J Cell Sci 1996;109:1369-1380
    Web of Science | Medline

38. 38

    Verhaar HJ, Damen CA, Duursma SA, Scheven BA. Comparison of the action of 17 beta-estradiol and progestins with insulin-like growth factors-I/-II and transforming growth factor-beta 1 on the growth of normal adult human bone-forming cells. Maturitas 1995;21:237-243
    CrossRef | Web of Science | Medline

39. 39

    Centrella M, McCarthy TL, Canalis E. Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone. Mol Cell Biol 1991;11:4490-4496
    Web of Science | Medline

40. 40

    Geiser AG, Zeng QQ, Sato M, Helvering LM, Hirano T, Turner CH. Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene. Bone 1998;23:87-93
    CrossRef | Web of Science | Medline

Citing Articles (537)

Citing Articles

1. 1

   Yong Wan, Cheng Lu, Jingjing Cao, Rujiang Zhou, Yiyun Yao, Jian Yu, Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Xuming Zhu, Lin He, Yongzhong Liu, Zhengju Yao, Xiao Yang, Xizhi Guo. (2013) Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells. Bone 55:1, 258-267
   

2. 2

   Eveline Boudin, Karen Jennes, Fenna de Freitas, David Tegay, Geert Mortier, Wim Van Hul. (2013) No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders. Bone 55:1, 52-56
   

3. 3

   Maurizio Rossini, Davide Gatti, Silvano Adami. (2013) Involvement of WNT/β-catenin Signaling in the Treatment of Osteoporosis. Calcified Tissue International
   

4. 4

   Travis A. Burgers, Bart O. Williams. (2013) Regulation of Wnt/β-catenin signaling within and from osteocytes. Bone 54:2, 244-249
   

5. 5

   Takamitsu Maruyama, Ming Jiang, Wei Hsu. (2013) Gpr177 , a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. Journal of Bone and Mineral Research 28:5, 1150-1159
   

6. 6

   Jianquan Chen, Fanxin Long. (2013) β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice. Journal of Bone and Mineral Research 28:5, 1160-1169
   

7. 7

   Tahir Naeem Khan, J. Klar, Zafar Ali, F. Khan, S.M. Baig, N. Dahl. (2013) Cenani–Lenz syndrome restricted to limb and kidney anomalies associated with a novel LRP4 missense mutation. European Journal of Medical Genetics
   

8. 8

   Azusa Yamada, Takanori Iwata, Masayuki Yamato, Teruo Okano, Yuichi Izumi. (2013) Diverse functions of secreted frizzled-related proteins in the osteoblastogenesis of human multipotent mesenchymal stromal cells. Biomaterials 34:13, 3270-3278
   

9. 9

   Shawna M. Pyott, Thao T. Tran, Dru F. Leistritz, Melanie G. Pepin, Nancy J. Mendelsohn, Renee T. Temme, Bridget A. Fernandez, Solaf M. Elsayed, Ezzat Elsobky, Ishwar Verma, Sreelata Nair, Emily H. Turner, Joshua D. Smith, Gail P. Jarvik, Peter H. Byers. (2013) WNT1 Mutations in Families Affected by Moderately Severe and Progressive Recessive Osteogenesis Imperfecta. The American Journal of Human Genetics 92:4, 590-597
   

10. 10

    Martyn K. Robinson, John Caminis, Mary E. Brunkow. (2013) Sclerostin: how human mutations have helped reveal a new target for the treatment of osteoporosis. Drug Discovery Today
    

11. 11

    Emel Esen, Jianquan Chen, Courtney M. Karner, Adewole L. Okunade, Bruce W. Patterson, Fanxin Long. (2013) WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation. Cell Metabolism
    

12. 12

    Richard S. Kao, Marcia J. Abbott, Alyssa Louie, Dylan O'Carroll, Weidar Lu, Robert Nissenson. (2013) Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. Bone
    

13. 13

    J. Keller, T. Schinke. (2013) The role of the gastrointestinal tract in calcium homeostasis and bone remodeling. Osteoporosis International
    

14. 14

    Xuetao Shi, Song Chen, Yihua Zhao, Chen Lai, Hongkai Wu. (2013) Enhanced Osteogenesis by a Biomimic Pseudo-Periosteum-Involved Tissue Engineering Strategy. Advanced Healthcare Materialsn/a-n/a
    

15. 15

    Edith Falcón-Ramírez, Leonora Casas-Avila, Ricardo M. Cerda-Flores, Clementina Castro-Hernández, Julieta Rubio-Lightbourn, Rafael Velázquez-Cruz, Pilar Diez-G, Rosenda Peñaloza-Espinosa, Margarita Valdés-Flores. (2013) Association of LRP5 haplotypes with osteoporosis in Mexican women. Molecular Biology Reports 40:3, 2705-2710
    

16. 16

    P. P. Dwivedi, N. Lam, B. C. Powell. (2013) Boning up on glypicans-opportunities for new insights into bone biology. Cell Biochemistry and Function 31:2, 91-114
    

17. 17

    Marc-Olivier Montjovent, Mark Siegrist, Frank Klenke, Antoinette Wetterwald, Silvia Dolder, Willy Hofstetter. (2013) Expression of antagonists of WNT and BMP signaling after non-rigid fixation of osteotomies. Bone 53:1, 79-86
    

18. 18

    Sandra Jastrzebski, Judith Kalinowski, Marina Stolina, Faryal Mirza, Elena Torreggiani, Ivo Kalajzic, Hee Yeon Won, Sun-Kyeong Lee, Joseph Lorenzo. (2013) Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels. Journal of Bone and Mineral Research 28:3, 618-626
    

19. 19

    Alexander G. Robling. (2013) The expanding role of Wnt signaling in bone metabolism. Bone
    

20. 20

    C. L. Gregson, S. A. Hardcastle, C. Cooper, J. H. Tobias. (2013) Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management. Rheumatology
    

21. 21

    J. Albers, J. Keller, A. Baranowsky, F. T. Beil, P. Catala-Lehnen, J. Schulze, M. Amling, T. Schinke. (2013) Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin. The Journal of Cell Biology 200:4, 537-549
    

22. 22

    Roland Baron, Michaela Kneissel. (2013) WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nature Medicine 19:2, 179-192
    

23. 23

    Joseph S. Butler, Eilis C. Dunning, David W. Murray, Peter P. Doran, John M. O'Byrne. (2013) HIV-1 protein induced modulation of primary human osteoblast differentiation and function via a Wnt/β-catenin-dependent mechanism. Journal of Orthopaedic Research 31:2, 218-226
    

24. 24

    Z. Zhong, X.-L. Zeng, J.-H. Ni, X.-F. Huang. (2013) Comparison of the biological response of osteoblasts after tension and compression. The European Journal of Orthodontics 35:1, 59-65
    

25. 25

    J R Ferreira, M L Hirsch, L Zhang, Y Park, R J Samulski, W-S Hu, C-C Ko. (2013) Three-dimensional multipotent progenitor cell aggregates for expansion, osteogenic differentiation and ‘in vivo’ tracing with AAV vector serotype 6. Gene Therapy 20:2, 158-168
    

26. 26

    Kenyi Saito-Diaz, Tony W. Chen, Xiaoxi Wang, Curtis A. Thorne, Heather A. Wallace, Andrea Page-McCaw, Ethan Lee. (2013) The way Wnt works: Components and mechanism. Growth Factors 31:1, 1-31
    

27. 27

    Joseph Caverzasio, Emmanuel Biver, Cyril Thouverey. (2013) Predominant role of PDGF receptor transactivation in Wnt3a-induced osteoblastic cell proliferation. Journal of Bone and Mineral Research 28:2, 260-270
    

28. 28

    Eveline Boudin, Igor Fijalkowski, Elke Piters, Wim Van Hul. (2013) The role of extracellular modulators of canonical Wnt signaling in bone metabolism and diseases. Seminars in Arthritis and Rheumatism
    

29. 29

    Patricia Ducy. Gut-derived Serotonin and Bone Formation. In: Translational Endocrinology of Bone. Elsevier, 2013:73-82.
    

30. 30

    Stavroula Kousteni. Transcriptional Regulation of the Endocrine Function of Bone. In: Translational Endocrinology of Bone. Elsevier, 2013:93-102.
    

31. 31

    T. John Martin, Kong Wah Ng, Natalie A. Sims. Basic Principles of Bone Cell Biology. In: Translational Endocrinology of Bone. Elsevier, 2013:5-26.
    

32. 32

    Brendan F. Boyce, Michael J. Zuscik, Lianping Xing. Biology of Bone and Cartilage. In: Genetics of Bone Biology and Skeletal Disease. Elsevier, 2013:3-24.
    

33. 33

    Mathieu Ferron, Franck Oury, Gerard Karsenty. Energy Homeostasis and Neuronal Regulation of Bone Remodeling. In: Genetics of Bone Biology and Skeletal Disease. Elsevier, 2013:69-80.
    

34. 34

    Bram Perdu, Wim Van Hul. Sclerosing Bone Disorders. In: Genetics of Bone Biology and Skeletal Disease. Elsevier, 2013:361-374.
    

35. 35

    Tuan V. Nguyen, John A. Eisman. Pharmacogenetics and Pharmacogenomics of Osteoporosis. In: Genetics of Bone Biology and Skeletal Disease. Elsevier, 2013:151-167.
    

36. 36

    Fernando Rivadeneira, André G. Uitterlinden. Osteoporosis Genes Identified by Genome-wide Association Studies. In: Genetics of Bone Biology and Skeletal Disease. Elsevier, 2013:243-256.
    

37. 37

    Olivier Drevelle, Alex Daviau, Marc-Antoine Lauzon, Nathalie Faucheux. (2013) Effect of BMP-2 and/or BMP-9 on preosteoblasts attached to polycaprolactone functionalized by adhesive peptides derived from bone sialoprotein. Biomaterials 34:4, 1051-1062
    

38. 38

    Rongrong Zhang, Babatunde O. Oyajobi, Stephen E. Harris, Di Chen, Christopher Tsao, Hong-Wen Deng, Ming Zhao. (2013) Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone 52:1, 145-156
    

39. 39

    Celia L. Gregson, Adrian Sayers, Victor Lazar, Sue Steel, Elaine M. Dennison, Cyrus Cooper, George Davey Smith, Jörn Rittweger, Jon H. Tobias. (2013) The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: Findings from a pQCT case–control study. Bone 52:1, 380-388
    

40. 40

    Nancy E. Lane. Metabolic Bone Disease. In: Kelley's Textbook of Rheumatology. Elsevier, 2013:1660-1679.e4.
    

41. 41

    J.-F. Collard, C. Lazar, A. Nowé, M. Hinsenkamp. (2013) Statistical validation of the acceleration of the differentiation at the expense of the proliferation in human epidermal cells exposed to extremely low frequency electric fields. Progress in Biophysics and Molecular Biology 111:1, 37-45
    

42. 42

    Nicola Giuliani, Gina Lisignoli, Marina Magnani, Costantina Racano, Marina Bolzoni, Benedetta Dalla Palma, Angelica Spolzino, Cristina Manferdini, Caterina Abati, Denise Toscani, Andrea Facchini, Franco Aversa. (2013) New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics. Stem Cells International 2013, 1-11
    

43. 43

    Pascal Amireault, David Sibon, Francine Côté. (2012) Life without Peripheral Serotonin: Insights from Tryptophan Hydroxylase 1 Knockout Mice Reveal the Existence of Paracrine/Autocrine Serotonergic Networks. ACS Chemical Neuroscience121203091158001
    

44. 44

    Richard Kao, Weidar Lu, Alyssa Louie, Robert Nissenson. (2012) Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes. Endocrine 42:3, 622-636
    

45. 45

    Francesco Massart, Francesca Marini, Gerolamo Bianchi, Salvatore Minisola, Giovanni Luisetto, Antonella Pirazzoli, Sara Salvi, Dino Micheli, Mario Miccoli, Angelo Baggiani, Francesca Giusti, Maria Luisa Brandi. (2012) Genetic predictors of skeletal outcomes in healthy fertile women: The Bonturno Study. Joint Bone Spine
    

46. 46

    Zuzana Saidak, Pierre J. Marie. (2012) Strontium signaling: Molecular mechanisms and therapeutic implications in osteoporosis. Pharmacology & Therapeutics 136:2, 216-226
    

47. 47

    Baosheng Guo, Songlin Peng, Chao Liang, Xiaojuan He, Cheng Xiao, Cheng Lu, Miao Jiang, Hongyan Zhao, Aiping Lu, Ge Zhang. (2012) Recent developments in bone anabolic therapy for osteoporosis. Expert Review of Endocrinology & Metabolism 7:6, 677-685
    

48. 48

    Johanna Korvala, Marika Löija, Outi Mäkitie, Etienne Sochett, Harald Jüppner, Dirk Schnabel, Stefano Mora, William G. Cole, Leena Ala-Kokko, Minna Männikkö. (2012) Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis. European Journal of Medical Genetics 55:10, 515-519
    

49. 49

    Aruna Kode, Ioanna Mosialou, Barbara C. Silva, Marie-Therese Rached, Bin Zhou, Ji Wang, Tim M. Townes, Rene Hen, Ronald A. DePinho, X. Edward Guo, Stavroula Kousteni. (2012) FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. Journal of Clinical Investigation 122:10, 3490-3503
    

50. 50

    Eveline Boudin, Elke Piters, Igor Fijalkowski, Gino Stevenheydens, Ellen Steenackers, Outi Kuismin, Jukka S. Moilanen, Geert Mortier, Wim Van Hul. (2012) Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis. Bone
    

51. 51

    Juan Zhang, Xiaofei Zhang, Long Zhang, Fangfang Zhou, Maarten van Dinther, Peter ten Dijke. (2012) LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation. Journal of Bone and Mineral Research 27:10, 2065-2074
    

52. 52

    Tuan V. Nguyen, John A. Eisman. (2012) Genetics and the Individualized Prediction of Fracture. Current Osteoporosis Reports 10:3, 236-244
    

53. 53

    Paul J. Niziolek, Matthew L. Warman, Alexander G. Robling. (2012) Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner. Bone 51:3, 459-465
    

54. 54

    Takashi Watanabe, Yoshihiro Tamamura, Akiyoshi Hoshino, Yuji Makino, Hiroshi Kamioka, Teruo Amagasa, Akira Yamaguchi, Tadahiro Iimura. (2012) Increasing participation of sclerostin in postnatal bone development, revealed by three-dimensional immunofluorescence morphometry. Bone 51:3, 447-458
    

55. 55

    Zhendong Zhong, Bart O Williams. (2012) Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass. Journal of Bone and Mineral Research 27:9, 1849-1851
    

56. 56

    Z. Zhong, C. R. Zylstra-Diegel, C. A. Schumacher, J. J. Baker, A. C. Carpenter, S. Rao, W. Yao, M. Guan, J. A. Helms, N. E. Lane, R. A. Lang, B. O. Williams. (2012) PNAS Plus: Wntless functions in mature osteoblasts to regulate bone mass. Proceedings of the National Academy of Sciences 109:33, E2197-E2204
    

57. 57

    Sarah M. Churchman, Frederique Ponchel, Sally A. Boxall, Richard Cuthbert, Dimitrios Kouroupis, Tarek Roshdy, Peter V. Giannoudis, Paul Emery, Dennis McGonagle, Elena A. Jones. (2012) Transcriptional profile of native CD271+ multipotential stromal cells: Evidence for multiple fates, with prominent osteogenic and Wnt pathway signaling activity. Arthritis & Rheumatism 64:8, 2632-2643
    

58. 58

    Danjun Ma, Yan Li, Bryan Hackfort, Yingchun Zhao, Jing Xiao, Patrick C. Swanson, Joan Lappe, Peng Xiao, Diane Cullen, Mohammed Akhter, Robert Recker, Gary Guishan Xiao. (2012) Smoke-Induced Signal Molecules in Bone Marrow Cells from Altered Low-Density Lipoprotein Receptor-Related Protein 5 Mice. Journal of Proteome Research 11:7, 3548-3560
    

59. 59

    Joseph L Sottnik, Christopher L Hall, Jian Zhang, Evan T Keller. (2012) Wnt and Wnt inhibitors in bone metastasis. BoneKEy Reports 1:7,
    

60. 60

    Guofeng Li, Jingren Xu, Zengchun Li. (2012) Receptor for advanced glycation end products inhibits proliferation in osteoblast through suppression of Wnt, PI3K and ERK signaling. Biochemical and Biophysical Research Communications 423:4, 684-689
    

61. 61

    Wim Van Hul. (2012) Sclerosing bone disorders: a lot of knowns but still some unknowns. BoneKEy Reports 1:6,
    

62. 62

    Kristen R. Georgiou, Tristan J. King, Michaela A. Scherer, Hong Zhou, Bruce K. Foster, Cory J. Xian. (2012) Attenuated Wnt/β-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone 50:6, 1223-1233
    

63. 63

    Hans Clevers, Roel Nusse. (2012) Wnt/β-Catenin Signaling and Disease. Cell 149:6, 1192-1205
    

64. 64

    Young-Dan Cho, Woo-Jin Kim, Won-Joon Yoon, Kyung-Mi Woo, Jeong-Hwa Baek, Gene Lee, Gwan-Shik Kim, Hyun-Mo Ryoo. (2012) Wnt3a stimulates Mepe , Matrix extracellular phosphoglycoprotein , expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression. Journal of Cellular Physiology 227:6, 2287-2296
    

65. 65

    J. Bao, J. J. Zheng, D. Wu. (2012) The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling. Science Signaling 5:224, pe22-pe22
    

66. 66

    William R. Thompson, Clinton T. Rubin, Janet Rubin. (2012) Mechanical regulation of signaling pathways in bone. Gene
    

67. 67

    Eiji Nemoto, Yukari Ebe, Sousuke Kanaya, Masahiro Tsuchiya, Takashi Nakamura, Masato Tamura, Hidetoshi Shimauchi. (2012) Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis. Biochemical and Biophysical Research Communications
    

68. 68

    Fangfang Zhou, Huizhe Huang, Long Zhang. (2012) Bisindoylmaleimide I enhances osteogenic differentiation. Protein & Cell 3:4, 311-320
    

69. 69

    Jasreen Kular, Jennifer Tickner, Shek Man Chim, Jiake Xu. (2012) An overview of the regulation of bone remodelling at the cellular level. Clinical Biochemistry
    

70. 70

    Long Zhang, Songting Shi, Juan Zhang, Fangfang Zhou, Peter ten Dijke. (2012) Wnt/β-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression. Biochemical and Biophysical Research Communications
    

71. 71

    C. Zuo, Y. Huang, R. Bajis, M. Sahih, Y.-P. Li, K. Dai, X. Zhang. (2012) Osteoblastogenesis regulation signals in bone remodeling. Osteoporosis International
    

72. 72

    Gérard Karsenty, Mathieu Ferron. (2012) The contribution of bone to whole-organism physiology. Nature 481:7381, 314-320
    

73. 73

    Mark L Johnson. (2012) LRP5 and bone mass regulation: Where are we now?. BoneKEy Reports 1,
    

74. 74

    Noriaki Ono, Kazuhisa Nakashima, Ernestina Schipani, Tadayoshi Hayata, Yoichi Ezura, Kunimichi Soma, Henry M. Kronenberg, Masaki Noda. (2012) Constitutively active PTH/PTHrP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation. Journal of Cellular Physiology 227:2, 408-415
    

75. 75

    David L. Stocum. Regeneration of Musculoskeletal Tissues. In: Regenerative Biology and Medicine. Elsevier, 2012:127-160.
    

76. 76

    Johanna Korvala, Harald Juppner, Outi Makitie, Etienne Sochett, Dirk Schnabel, Stefano Mora, Cynthia F Bartels, Matthew L Warman, Donald Deraska, William G Cole, Heini Hartikka, Leena Ala-Kokko, Minna Mannikko. (2012) Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Medical Genetics 13:1, 26
    

77. 77

    Yurong Fei, Marja M. Hurley. (2012) Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation. Journal of Cellular Physiologyn/a-n/a
    

78. 78

    Bram Perdu, Geert Mortier, Filip Vanhoenacker, Wim Van Hul. Sclerosing Bone Dysplasias. In: Pediatric Bone. Elsevier, 2012:541-556.
    

79. 79

    Jean-Philippe Bonjour, Thierry Chevalley, Serge Ferrari, Rene Rizzoli. Peak Bone Mass and Its Regulation. In: Pediatric Bone. Elsevier, 2012:189-221.
    

80. 80

    Christa Maes, Henry M. Kronenberg. Postnatal Bone Growth: Growth Plate Biology, Bone Formation, and Remodeling. In: Pediatric Bone. Elsevier, 2012:55-82.
    

81. 81

    B.L. Clarke. (2012) Levels of Serotonin, Sclerostin, Bone Turnover Markers as well as Bone Density and Microarchitecture in Patients With High-Bone-Mass Phenotype Due to a Mutation in Lrp5. Yearbook of Endocrinology 2012, 230-232
    

82. 82

    Min-Seock Seo, Kyung-Gyun Hwang, Hyongbum Kim, Seung-Ho Baek. (2012) Analysis of gene expression during odontogenic differentiation of cultured human dental pulp cells. Restorative Dentistry & Endodontics 37:3, 142
    

83. 83

    Sara Iozzi, Rosaria Remelli, Barbara Lelli, Daniela Diamanti, Silvia Pileri, Luisa Bracci, Renza Roncarati, Andrea Caricasole, Simonetta Bernocco. (2012) Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction. ISRN Molecular Biology 2012, 1-9
    

84. 84

    Je-Yong Choi. (2012) New Avenues in the LRP5-mediated Bone Mass Acquisition. Korean Journal of Bone Metabolism 19:1, 1
    

85. 85

    Yingzi Yang. (2012) Wnt signaling in development and disease. Cell & Bioscience 2:1, 14
    

86. 86

    Sajida Piperdi, Lukas Austin-Page, David Geller, Manpreet Ahluwalia, Sarah Gorlick, Jonathan Gill, Amy Park, Wendong Zhang, Nan Li, So Hak Chung, Richard Gorlick. (2012) β-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells. Sarcoma 2012, 1-10
    

87. 87

    Wei Zhang, Matthew T. Drake. (2011) Potential Role for Therapies Targeting DKK1, LRP5, and Serotonin in the Treatment of Osteoporosis. Current Osteoporosis Reports
    

88. 88

    Fanxin Long. (2011) Building strong bones: molecular regulation of the osteoblast lineage. Nature Reviews Molecular Cell Biology 13:1, 27-38
    

89. 89

    R. S. Tarapore, I. A. Siddiqui, H. Mukhtar. (2011) Modulation of Wnt/ -catenin signaling pathway by bioactive food components. Carcinogenesis
    

90. 90

    T C Luis, M Ichii, M H Brugman, P Kincade, F J T Staal. (2011) Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia
    

91. 91

    Kevin A. Tompkins. (2011) Wnt Proteins in Mineralized Tissue Development and Homeostasis. Connective Tissue Research 52:6, 448-458
    

92. 92

    Grace L. Lin, Kurt D. Hankenson. (2011) Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. Journal of Cellular Biochemistry 112:12, 3491-3501
    

93. 93

    V. L. Katanaev, M. V. Kryuchkov. (2011) The eye of Drosophila as a model system for studying intracellular signaling in ontogenesis and pathogenesis. Biochemistry (Moscow) 76:13, 1556-1581
    

94. 94

    Hemamalini Devarajan-Ketha, Theodore A. Craig, Benjamin J. Madden, H. Robert Bergen, Rajiv Kumar. (2011) The sclerostin-bone protein interactome. Biochemical and Biophysical Research Communications
    

95. 95

    Derya Aslan, Mille Dahl Andersen, Lene Bjerring Gede, Tine Kellemann de Franca, Sara Rubek Jørgensen, Peter Schwarz, Niklas Rye Jørgensen. (2011) Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans. Scandinavian Journal of Clinical & Laboratory Investigation1-9
    

96. 96

    David G. Monroe, Meghan E. McGee-Lawrence, Merry Jo Oursler, Jennifer J. Westendorf. (2011) Update on Wnt signaling in bone cell biology and bone disease. Gene
    

97. 97

    Shuo Chen, Doryen Bubeck, Bryan T. MacDonald, Wen-Xue Liang, Jian-Hua Mao, Tomas Malinauskas, Oscar Llorca, A. Radu Aricescu, Christian Siebold, Xi He, E. Yvonne Jones. (2011) Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling. Developmental Cell 21:5, 848-861
    

98. 98

    Xiaodong Li, Mario Grisanti, Wei Fan, Frank J Asuncion, Hong-Lin Tan, Denise Dwyer, Chun-Ya Han, Longchuan Yu, Jae Lee, Edward Lee, Mauricio Barrero, Pam Kurimoto, Qing-Tian Niu, Zhaopo Geng, Aaron Winters, Tom Horan, Shirley Steavenson, Frederick Jacobsen, Qing Chen, Raj Haldankar, Jennifer Lavallee, Barbara Tipton, Mark Daris, Jackie Sheng, Hsieng S Lu, Kristi Daris, Rohini Deshpande, Eliane G Valente, Hossein Salimi-Moosavi, Paul J Kostenuik, Ji Li, Min Liu, Chaoyang Li, David L Lacey, W Scott Simonet, Hua Zhu Ke, Philip Babij, Marina Stolina, Michael S Ominsky, William G Richards. (2011) Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury. Journal of Bone and Mineral Research 26:11, 2610-2621
    

99. 99

    Zhihong Cheng, Travis Biechele, Zhiyi Wei, Seamus Morrone, Randall T Moon, Liguo Wang, Wenqing Xu. (2011) Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nature Structural & Molecular Biology 18:11, 1204-1210
    

100. 100

     Gregory A Clines, Khalid S Mohammad, Jessica M Grunda, Katrina L Clines, Maria Niewolna, C Ryan McKenna, Christopher R McKibbin, Masashi Yanagisawa, Larry J Suva, John M Chirgwin, Theresa A Guise. (2011) Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor. Journal of Bone and Mineral Research 26:10, 2523-2536
     

101. 101

     Dimitrios Daoussis, Andrew P. Andonopoulos. (2011) The Emerging Role of Dickkopf-1 in Bone Biology: Is It the Main Switch Controlling Bone and Joint Remodeling?. Seminars in Arthritis and Rheumatism 41:2, 170-177
     

102. 102

     Nalini M. Rajamannan. (2011) The role of Lrp5/6 in cardiac valve disease: Experimental hypercholesterolemia in the ApoE−/−/Lrp5−/− mice. Journal of Cellular Biochemistry 112:10, 2987-2991
     

103. 103

     Jeong Kyo Yoon, Jin-Seon Lee. (2011) Cellular signaling and biological functions of R-spondins. Cellular Signalling
     

104. 104

     Eric Bourhis, Weiru Wang, Christine Tam, Jiyoung Hwang, Yingnan Zhang, Didier Spittler, Oscar W. Huang, Yan Gong, Alberto Estevez, Inna Zilberleyb, Lionel Rouge, Cecilia Chiu, Yan Wu, Mike Costa, Rami N. Hannoush, Yvonne Franke, Andrea G. Cochran. (2011) Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6. Structure 19:10, 1433-1442
     

105. 105

     Shuanhu Zhou, Ericka M. Bueno, Sung Won Kim, Ilaria Amato, Longxiang Shen, Jochen Hahne, Ilan Bleiberg, Paul Morley, Julie Glowacki. (2011) Effects of age on parathyroid hormone signaling in human marrow stromal cells. Aging Cell 10:5, 780-788
     

106. 106

     Xin Wen, William P. Cawthorn, Ormond A. MacDougald, Samuel I. Stupp, Malcolm L. Snead, Yan Zhou. (2011) The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression. Biomaterials 32:27, 6478-6486
     

107. 107

     Nalini M. Rajamannan. (2011) The role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory. Journal of Cellular Biochemistry 112:9, 2222-2229
     

108. 108

     Franck Oury, Gerard Karsenty. (2011) Towards a serotonin-dependent leptin roadmap in the brain. Trends in Endocrinology & Metabolism 22:9, 382-387
     

109. 109

     Alessandra Pangrazio, Eveline Boudin, Elke Piters, Giuseppe Damante, Nadia Lo Iacono, Angela Valentina D'Elia, Paolo Vezzoni, Wim Van Hul, Anna Villa, Cristina Sobacchi. (2011) Identification of the first deletion in the LRP5 gene in a patient with Autosomal Dominant Osteopetrosis type I. Bone 49:3, 568-571
     

110. 110

     Kyu Sang Joeng, Cassie A. Schumacher, Cassandra R. Zylstra-Diegel, Fanxin Long, Bart O. Williams. (2011) Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Developmental Biology
     

111. 111

     Hongbin Liu, Rongrong Zhang, Seon-Yle Ko, Babatunde O Oyajobi, Christopher J Papasian, Hong-Wen Deng, Shujun Zhang, Ming Zhao. (2011) Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: Stathmin deficiency produces an osteopenic phenotype in mice. Journal of Bone and Mineral Research 26:9, 2052-2067
     

112. 112

     David Goltzman. (2011) LRP5, serotonin, and bone: Complexity, contradictions, and conundrums. Journal of Bone and Mineral Research 26:9, 1997-2001
     

113. 113

     Leanne K. Saxon, Brendan F. Jackson, Toshihiro Sugiyama, Lance E. Lanyon, Joanna S. Price. (2011) Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone 49:2, 184-193
     

114. 114

     C M Laine, B D Chung, M Susic, T Prescott, O Semler, T Fiskerstrand, P D'Eufemia, M Castori, M Pekkinen, E Sochett, W G Cole, C Netzer, O Mäkitie. (2011) Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG). European Journal of Human Genetics 19:8, 875-881
     

115. 115

     P. Habibovic, J.E. Barralet. (2011) Bioinorganics and biomaterials: Bone repair. Acta Biomaterialia 7:8, 3013-3026
     

116. 116

     Gerard Karsenty, Michael D. Gershon. (2011) The Importance of the Gastrointestinal Tract in the Control of Bone Mass Accrual. Gastroenterology 141:2, 439-442
     

117. 117

     Morten Frost, Tom Andersen, Fatma Gossiel, Stinus Hansen, Jens Bollerslev, Wim van Hul, Richard Eastell, Moustapha Kassem, Kim Brixen. (2011) Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5. Journal of Bone and Mineral Research 26:8, 1721-1728
     

118. 118

     Jin Zhang, Qisheng Tu, Lynda F Bonewald, Xi He, Gary Stein, Jane Lian, Jake Chen. (2011) Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. Journal of Bone and Mineral Research 26:8, 1953-1963
     

119. 119

     Julie C Baker-LePain, Mary C Nakamura, Nancy E Lane. (2011) Effects of inflammation on bone: an update. Current Opinion in Rheumatology 23:4, 389-395
     

120. 120

     Shuanhu Zhou. (2011) TGF-β regulates β-catenin signaling and osteoblast differentiation in human mesenchymal stem cells. Journal of Cellular Biochemistry 112:6, 1651-1660
     

121. 121

     Rene Olivares-Navarrete, Sharon L. Hyzy, Daphne L. Hutton, Ginger R. Dunn, Christoph Appert, Barbara D. Boyan, Zvi Schwartz. (2011) Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces. Acta Biomaterialia 7:6, 2740-2750
     

122. 122

     Yajun Cui, Paul J Niziolek, Bryan T MacDonald, Cassandra R Zylstra, Natalia Alenina, Daniel R Robinson, Zhendong Zhong, Susann Matthes, Christina M Jacobsen, Ronald A Conlon, Robert Brommage, Qingyun Liu, Faika Mseeh, David R Powell, Qi M Yang, Brian Zambrowicz, Han Gerrits, Jan A Gossen, Xi He, Michael Bader, Bart O Williams, Matthew L Warman, Alexander G Robling. (2011) Lrp5 functions in bone to regulate bone mass. Nature Medicine 17:6, 684-691
     

123. 123

     Nalini M. Rajamannan. (2011) Bicuspid aortic valve disease: the role of oxidative stress in Lrp5 bone formation. Cardiovascular Pathology 20:3, 168-176
     

124. 124

     Ann-Marie Rajalin, Piia Aarnisalo. (2011) Cross-talk between NR4A orphan nuclear receptors and β-catenin signaling pathway in osteoblasts. Archives of Biochemistry and Biophysics 509:1, 44-51
     

125. 125

     P. Wend, K. Wend, S. A. Krum, G. A. Miranda-Carboni. (2011) The role of WNT10B in physiology and disease. Acta Physiologicano-no
     

126. 126

     Maripat Corr. WNT/_-Catenin Signaling Modulating Osteoarthritis. In: Arthritis. CRC Press, 2011:91-101.
     

127. 127

     Fredrik Agholme, Per Aspenberg. (2011) Wnt signaling and orthopedics, an overview. Acta Orthopaedica 82:2, 125-130
     

128. 128

     C. L. Gregson, S. A. Steel, K. P. O’Rourke, K. Allan, J. Ayuk, A. Bhalla, G. Clunie, N. Crabtree, I. Fogelman, A. Goodby, C. M. Langman, S. Linton, E. Marriott, E. McCloskey, K. E. Moss, T. Palferman, S. Panthakalam, K. E. S. Poole, M. D. Stone, J. Turton, D. Wallis, S. Warburton, J. Wass, E. L. Duncan, M. A. Brown, G. Davey-Smith, J. H. Tobias. (2011) ‘Sink or swim’: an evaluation of the clinical characteristics of individuals with high bone mass. Osteoporosis International
     

129. 129

     J. Albers, J. Schulze, F. T. Beil, M. Gebauer, A. Baranowsky, J. Keller, R. P. Marshall, K. Wintges, F. W. Friedrich, M. Priemel, A. F. Schilling, J. M. Rueger, K. Cornils, B. Fehse, T. Streichert, G. Sauter, F. Jakob, K. L. Insogna, B. Pober, K.-P. Knobeloch, U. Francke, M. Amling, T. Schinke. (2011) Control of bone formation by the serpentine receptor Frizzled-9. The Journal of Cell Biology 192:6, 1057-1072
     

130. 130

     Dragan Mladenović, Dragutin Stanković, Sanja Mladenović, Nataša Đinđić, Lidija Mladenović. (2011) DEGREE OF PROMINENCE OF PALATAL EXOSTOSIS AND SPECIFICITIES OF FABRICATION OF TOTAL PROSTHESIS. Acta Medica Medianae 50:1, 54-59
     

131. 131

     Ka To Shum, Celine Chan, ChingMan Leung, Julian A. Tanner. (2011) Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling. Biochemical Journal 434:3, 493-501
     

132. 132

     Joseph S. Butler, David W. Murray, Conor J. Hurson, Julie O'Brien, Peter P. Doran, John M. O'Byrne. (2011) The role of Dkk1 in bone mass regulation: Correlating serum Dkk1 expression with bone mineral density. Journal of Orthopaedic Research 29:3, 414-418
     

133. 133

     Christian Köhler, Janet K. Lighthouse, Tobias Werther, Olav M. Andersen, Annette Diehl, Peter Schmieder, Jianguang Du, Bernadette C. Holdener, Hartmut Oschkinat. (2011) The Structure of MESD45–184 Brings Light into the Mechanism of LDLR Family Folding. Structure 19:3, 337-348
     

134. 134

     Gang-Qing Yao, Jian-Jun Wu, Nancy Troiano, Karl Insogna. (2011) Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice. Journal of Bone and Mineral Metabolism 29:2, 141-148
     

135. 135

     Gerard Karsenty, Vijay K. Yadav. (2011) Regulation of Bone Mass by Serotonin: Molecular Biology and Therapeutic Implications. Annual Review of Medicine 62:1, 323-331
     

136. 136

     Gerard Karsenty. (2011) Bone as an Endocrine Tissue. Annual Review of Physiology 74:1, 110301101907077
     

137. 137

     Anna Neve, Addolorata Corrado, Francesco Paolo Cantatore. (2011) Osteoblast physiology in normal and pathological conditions. Cell and Tissue Research 343:2, 289-302
     

138. 138

     Patricia Ducy. (2011) 5-HT and bone biology. Current Opinion in Pharmacology 11:1, 34-38
     

139. 139

     Masanobu Kawai, Ulrike I. Mödder, Sundeep Khosla, Clifford J. Rosen. (2011) Emerging therapeutic opportunities for skeletal restoration. Nature Reviews Drug Discovery 10:2, 141-156
     

140. 140

     Matthew D. Kwan, Natalina Quarto, Deepak M. Gupta, Bethany J. Slater, Derrick C. Wan, Michael T. Longaker. (2011) Differential Expression of Sclerostin in Adult and Juvenile Mouse Calvariae. Plastic and Reconstructive Surgery 127:2, 595-602
     

141. 141

     Jean-Francois Collard, Benjamin Mertens, Maurice Hinsenkamp. (2011) In vitro study of the effects of ELF electric fields on gene expression in human epidermal cells. Bioelectromagnetics 32:1, 28-36
     

142. 142

     Dragan Mladenović, Dragutin Stanković, Sanja Mladenović, Nataša Đinđić, Lidija Mladenović. (2011) IZRAŽENOST NEPČANE EGZOSTOZE I SPECIFIČNOSTI IZRADE TOTALNE PROTEZE. Acta medica medianae54-59
     

143. 143

     A. Lindahl. Chondrocyte Transplantation and Selection. In: Comprehensive Biomaterials. Elsevier, 2011:189-198.
     

144. 144

     Janine A. Danks, Damian G. D’Souza, Haley J. Gunn, Kristi M. Milley, Samantha J. Richardson. (2011) Evolution of the parathyroid hormone family and skeletal formation pathways. General and Comparative Endocrinology 170:1, 79-91
     

145. 145

     Yang Huang, Xiaoling Zhang, Kewei Du, Fei Yang, Yu Shi, Jingang Huang, Tingting Tang, Di Chen, Kerong Dai. (2011) Inhibition of β-catenin signaling in chondrocytes induces delayed fracture healing in mice. Journal of Orthopaedic Researchn/a-n/a
     

146. 146

     Toshio Matsumoto, Rika Kuriwaka-Kido, Takeshi Kondo, Itsuro Endo, Shinsuke Kido. (2011) Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling [Review]. Endocrine Journal
     

147. 147

     Mitsuaki Ono, Colette A Inkson, Tina M Kilts, Marian F Young. (2011) WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. Journal of Bone and Mineral Research 26:1, 193-208
     

148. 148

     Russell W. Chesney. Bone Structure, Growth, and Hormonal Regulation. In: Nelson Textbook of Pediatrics. Elsevier, 2011:2446-2446.e4.
     

149. 149

     José Manuel González-Sancho, María Jesús Larriba, Alberto Muñoz. Vitamin D and Wnt/β-Catenin Signaling. In: Vitamin D. Elsevier, 2011:235-250.
     

150. 150

     Peter R. Ebeling, John A. Eisman. Vitamin D and Osteoporosis. In: Vitamin D. Elsevier, 2011:1129-1144.
     

151. 151

     Joseph A. Lorenzo, Ernesto Canalis, Lawrence G. Raisz. Metabolic Bone Disease. In: Williams Textbook of Endocrinology. Elsevier, 2011:1305-1349.
     

152. 152

     Jane B. Lian, Ellen M. Gravallese, Gary S. Stein. Osteoblasts and their Signaling Pathways. In: Osteoimmunology. Elsevier, 2011:101-140.
     

153. 153

     T. John Martin, Natalie A. Sims, Julian M.W. Quinn. Interactions Among Osteoblasts, Osteoclasts, and Other Cells in Bone. In: Osteoimmunology. Elsevier, 2011:227-267.
     

154. 154

     Antoine Popelut, Scott M. Rooker, Philipp Leucht, Marie Medio, John B. Brunski, Jill A. Helms. (2010) The acceleration of implant osseointegration by liposomal Wnt3a. Biomaterials 31:35, 9173-9181
     

155. 155

     Kristen L. Lee, David A. Hoey, Christopher R. Jacobs. (2010) Primary Cilia-Mediated Mechanotransduction in Bone. Clinical Reviews in Bone and Mineral Metabolism 8:4, 201-212
     

156. 156

     Emanuela Mrak, Francesca Guidobono, Gianluigi Moro, Gianfranco Fraschini, Alessandro Rubinacci, Isabella Villa. (2010) Calcitonin gene-related peptide (CGRP) inhibits apoptosis in human osteoblasts by β-catenin stabilization. Journal of Cellular Physiology 225:3, 701-708
     

157. 157

     Takayuki Hosoi. (2010) Genetic aspects of osteoporosis. Journal of Bone and Mineral Metabolism 28:6, 601-607
     

158. 158

     Theodore A. Craig, Rajiv Kumar. (2010) Sclerostin–erbB-3 interactions: Modulation of erbB-3 activity by sclerostin. Biochemical and Biophysical Research Communications 402:2, 421-424
     

159. 159

     Jin-bo Yu, Yao-hua Ke, Jin-wei He, Hao Zhang, Wei-wei Hu, Yun-qiu Hu, Miao Li, Yu-juan Liu, Jie-mei Gu, Wen-zhen Fu, Gao Gao, Hua Yue, Wen-jin Xiao, Zhen-lin Zhang. (2010) No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families. Acta Pharmacologica Sinica 31:11, 1464-1469
     

160. 160

     Wataru Katagiri, Yoichi Yamada, Sayaka Nakamura, Kenji Ito, Kenji Hara, Hideharu Hibi, Minoru Ueda. (2010) Regulation of the Wnt Signaling Pathways during Cell Culture of Human Mesenchymal Stem Cells for Efficient Bone Regeneration. Oral Science International 7:2, 37-46
     

161. 161

     Wen-Feng Li, Shu-Xun Hou, Bin Yu, Dan Jin, Claude Férec, Jian-Min Chen. (2010) Genetics of osteoporosis: perspectives for personalized medicine. Personalized Medicine 7:6, 655-668
     

162. 162

     P. Ducy, G. Karsenty. (2010) The two faces of serotonin in bone biology. The Journal of Cell Biology 191:1, 7-13
     

163. 163

     Andrea Augello, Cosimo De Bari. (2010) The Regulation of Differentiation in Mesenchymal Stem Cells. Human Gene Therapy 21:10, 1226-1238
     

164. 164

     Xin Ye, Yanshu Wang, Jeremy Nathans. (2010) The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease. Trends in Molecular Medicine 16:9, 417-425
     

165. 165

     Hironori Hojo, Shinsuke Ohba, Fumiko Yano, Ung-il Chung. (2010) Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. Journal of Bone and Mineral Metabolism 28:5, 489-502
     

166. 166

     Dustin Baldridge, Oleg Shchelochkov, Brian Kelley,, Brendan Lee. (2010) Signaling Pathways in Human Skeletal Dysplasias. Annual Review of Genomics and Human Genetics 11:1, 189-217
     

167. 167

     Ching-Lung Cheung, Su-Mei Xiao, Annie W. C. Kung. (2010) Genetic epidemiology of age-related osteoporosis and its clinical applications. Nature Reviews Rheumatology 6:9, 507-517
     

168. 168

     Chris Paszty, Charles H Turner, Martyn K Robinson. (2010) Sclerostin: A gem from the genome leads to bone-building antibodies. Journal of Bone and Mineral Research 25:9, 1897-1904
     

169. 169

     Maria P Yavropoulou, Socrates E Papapoulos. (2010) Targeting the Wnt signaling pathway for the development of novel therapies for osteoporosis. Expert Review of Endocrinology & Metabolism 5:5, 711-722
     

170. 170

     S. A. Ettenberg, O. Charlat, M. P. Daley, S. Liu, K. J. Vincent, D. D. Stuart, A. G. Schuller, J. Yuan, B. Ospina, J. Green, Q. Yu, R. Walsh, S. Li, R. Schmitz, H. Heine, S. Bilic, L. Ostrom, R. Mosher, K. F. Hartlepp, Z. Zhu, S. Fawell, Y.-M. Yao, D. Stover, P. M. Finan, J. A. Porter, W. R. Sellers, I. M. Klagge, F. Cong. (2010) Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proceedings of the National Academy of Sciences 107:35, 15473-15478
     

171. 171

     M. J. C. Moester, S. E. Papapoulos, C. W. G. M. Löwik, R. L. Bezooijen. (2010) Sclerostin: Current Knowledge and Future Perspectives. Calcified Tissue International 87:2, 99-107
     

172. 172

     Jenny S. Fusby, Michele D. Kassmeier, Victoria L. Palmer, Greg A. Perry, Dirk K. Anderson, Bryan T. Hackfort, Gwen K. Alvarez, Diane M. Cullen, Mohammed P. Akhter, Patrick C. Swanson. (2010) Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4 ⁺ :CD8 ⁺ T-cell ratios are reversed by smoking cessation: Influence of bone mass on immune cell response to and recovery from smoke exposure. Inhalation Toxicology 22:9, 785-796
     

173. 173

     Shoji Ichikawa, Daniel L Koller, Leah R Padgett, Dongbing Lai, Siu L Hui, Munro Peacock, Tatiana Foroud, Michael J Econs. (2010) Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Journal of Bone and Mineral Research 25:8, 1821-1829
     

174. 174

     Amjad Javed, Haiyan Chen, Farah Y. Ghori. (2010) Genetic and Transcriptional Control of Bone Formation. Oral and Maxillofacial Surgery Clinics of North America 22:3, 283-293
     

175. 175

     T. A. Einhorn. (2010) The Wnt Signaling Pathway as a Potential Target for Therapies to Enhance Bone Repair. Science Translational Medicine 2:42, 42ps36-42ps36
     

176. 176

     Maria G. Stathopoulou, George V.Z. Dedoussis, George Trovas, Aikaterini Katsalira, Naomi Hammond, Panos Deloukas, George P. Lyritis. (2010) Low-Density Lipoprotein Receptor-Related Protein 5 Polymorphisms Are Associated with Bone Mineral Density in Greek Postmenopausal Women: An Interaction with Calcium Intake. Journal of the American Dietetic Association 110:7, 1078-1083
     

177. 177

     Stuart H. Ralston. (2010) Osteoporosis as an Hereditary Disease. Clinical Reviews in Bone and Mineral Metabolism 8:2, 68-76
     

178. 178

     Natasha Case, Janet Rubin. (2010) β-Catenin-A supporting role in the skeleton. Journal of Cellular Biochemistry 110:3, 545-553
     

179. 179

     Konstantinos Nikopoulos, Hanka Venselaar, Rob W.J. Collin, Rosa Riveiro-Alvarez, F. Nienke Boonstra, Johanna M.M. Hooymans, Arijit Mukhopadhyay, Deborah Shears, Marleen van Bers, Ilse J. de Wijs, Anthonie J. van Essen, Rolf H. Sijmons, Mauk A.D. Tilanus, C. Erik van Nouhuys, Carmen Ayuso, Lies H. Hoefsloot, Frans P.M. Cremers. (2010) Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP. Human Mutation 31:6, 656-666
     

180. 180

     Y.-P. Zhang, F.-Y. Deng, Y. Chen, Y.-F. Pei, Y. Fang, Y.-F. Guo, X. Guo, X.-G. Liu, Q. Zhou, Y.-J. Liu, H.-W. Deng. (2010) Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening. Osteoporosis International 21:5, 785-795
     

181. 181

     Vijay K. Yadav, Henrique Pierotti Arantes, Elizabete Ribeiro Barros, Marise Lazaretti-Castro, Patricia Ducy. (2010) Genetic Analysis of Lrp5 Function in Osteoblast Progenitors. Calcified Tissue International 86:5, 382-388
     

182. 182

     Emma L. Duncan, Matthew A. Brown. (2010) Mapping genes for osteoporosis—Old dogs and new tricks. Bone 46:5, 1219-1225
     

183. 183

     S. Minear, P. Leucht, J. Jiang, B. Liu, A. Zeng, C. Fuerer, R. Nusse, J. A. Helms. (2010) Wnt Proteins Promote Bone Regeneration. Science Translational Medicine 2:29, 29ra30-29ra30
     

184. 184

     Anne Saarinen, Tero Saukkonen, Tero Kivelä, Ulla Lahtinen, Christine Laine, Mirja Somer, Sanna Toiviainen-Salo, William G. Cole, Anna-Elina Lehesjoki, Outi Mäkitie. (2010) Low density lipoprotein receptor-related protein 5 ( LRP5 ) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. Clinical Endocrinology 72:4, 481-488
     

185. 185

     Dimitrios Daoussis, Andrew P. Andonopoulos, Stamatis-Nick C. Liossis. (2010) Wnt Pathway and IL-17: Novel Regulators of Joint Remodeling in Rheumatic Diseases. Looking Beyond the RANK-RANKL-OPG Axis. Seminars in Arthritis and Rheumatism 39:5, 369-383
     

186. 186

     Stuart H. Ralston. (2010) Genetics of osteoporosis. Annals of the New York Academy of Sciences 1192:1, 181-189
     

187. 187

     Marie-Christine De Vernejoul, Uwe Kornak. (2010) Heritable sclerosing bone disorders. Annals of the New York Academy of Sciences 1192:1, 269-277
     

188. 188

     Anne Saarinen, Mervi K. Mäyränpää, Anna-Elina Lehesjoki, Outi Mäkitie. (2010) Low-density lipoprotein receptor-related protein 5 (LRP5) variation in fracture prone children. Bone 46:4, 940-945
     

189. 189

     Vijay K. Yadav, Patricia Ducy. (2010) Lrp5 and bone formation. Annals of the New York Academy of Sciences 1192:1, 103-109
     

190. 190

     U. Krause, S. Harris, A. Green, J. Ylostalo, S. Zeitouni, N. Lee, C. A. Gregory. (2010) Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proceedings of the National Academy of Sciences 107:9, 4147-4152
     

191. 191

     Morten Frost, Tom Erenskjold Andersen, Vijay Yadav, Kim Brixen, Gerard Karsenty, Moustapha Kassem. (2010) Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin. Journal of Bone and Mineral Research 25:3, 673-675
     

192. 192

     Ya-Wei Qiang, Yu Chen, Nathan Brown, Bo Hu, Joshua Epstein, Bart Barlogie, John D. Shaughnessy Jr.. (2010) Characterization of Wnt/β-catenin signalling in osteoclasts in multiple myeloma. British Journal of Haematology 148:5, 726-738
     

193. 193

     Wen-Feng Li, Shu-Xun Hou, Bin Yu, Meng-Meng Li, Claude Férec, Jian-Min Chen. (2010) Genetics of osteoporosis: accelerating pace in gene identification and validation. Human Genetics 127:3, 249-285
     

194. 194

     Steeve Kwan Tat, Daniel Lajeunesse, Jean-Pierre Pelletier, Johanne Martel-Pelletier. (2010) Targeting subchondral bone for treating osteoarthritis: what is the evidence?. Best Practice & Research Clinical Rheumatology 24:1, 51-70
     

195. 195

     Yongping Cai, Alexander B Mohseny, Marcel Karperien, Pancras CW Hogendoorn, Gengyin Zhou, Anne-Marie Cleton-Jansen. (2010) Inactive Wnt/β-catenin pathway in conventional high-grade osteosarcoma. The Journal of Pathology 220:1, 24-33
     

196. 196

     Takuo Kubota, Toshimi Michigami, Keiichi Ozono. (2010) Wnt Signaling in Bone. Clinical Pediatric Endocrinology 19:3, 49-56
     

197. 197

     James J. Mason, Bart O. Williams. (2010) SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease. Journal of Osteoporosis 2010, 1-9
     

198. 198

     Francesca Marini, Maria Luisa Brandi. (2010) Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?. International Journal of Hypertension 2010, 1-16
     

199. 199

     Fanxin Long. (2010) Noncanonical Wnt Signaling in Bone. Endocrinology and Metabolism 25:2, 85
     

200. 200

     Theodore A. Craig, Resham Bhattacharya, Debabrata Mukhopadhyay, Rajiv Kumar. (2010) Sclerostin binds and regulates the activity of cysteine-rich protein 61. Biochemical and Biophysical Research Communications 392:1, 36-40
     

201. 201

     Nicole C. Walsh, Ellen M. Gravallese. (2010) Bone remodeling in rheumatic disease: a question of balance. Immunological Reviews 233:1, 301-312
     

202. 202

     Stuart J. Warden, Alexander G. Robling, Elizabeth M. Haney, Charles H. Turner, Michael M. Bliziotes. (2010) The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5). Bone 46:1, 4-12
     

203. 203

     David E. Komatsu, Michelle N. Mary, Robert Jason Schroeder, Alex G. Robling, Charles H. Turner, Stuart J. Warden. (2010) Modulation of Wnt signaling influences fracture repair. Journal of Orthopaedic Researchn/a-n/a
     

204. 204

     Adam M. Gilbert, Matthew G. Bursavich, Nippa Alon, Bheem M. Bhat, Frederick J. Bex, Michael Cain, Valerie Coleburn, Virginia Gironda, Paula Green, Diane B. Hauze, Yogendra Kharode, Girija Krishnamurthy, Matthew Kirisits, Ho-Sun Lam, Yao-Bin Liu, Sabrina Lombardi, Jeanne Matteo, Richard Murrills, John A. Robinson, Sally Selim, Michael Sharp, Raymond Unwalla, Usha Varadarajan, Weiguang Zhao, Paul J. Yaworsky. (2010) Hit to lead studies on (hetero)arylpyrimidines—Agonists of the canonical Wnt-β-catenin cellular messaging system. Bioorganic & Medicinal Chemistry Letters 20:1, 366-370
     

205. 205

     Jane B. Lian, Gary S. Stein. Osteoblast Biology. In: Fundamentals of Osteoporosis. Elsevier, 2010:55-112.
     

206. 206

     Sylvain Provot, Ernestina Schipani, Joy Wu, Henry Kronenberg. Development of the Skeleton. In: Fundamentals of Osteoporosis. Elsevier, 2010:203-231.
     

207. 207

     Mark L. Johnson, Robert R. Recker. Wnt Signaling in Bone. In: Fundamentals of Osteoporosis. Elsevier, 2010:429-452.
     

208. 208

     Luigi Gennari, Robert Klein, Serge Ferrari. The Genetics of Peak Bone Mass. In: Osteoporosis in Men. Elsevier, 2010:149-163.
     

209. 209

     Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard J. Murrills, Peter V.N. Bodine. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and PTH Signaling Pathways. In: Bone Cancer. Elsevier, 2010:47-58.
     

210. 210

     Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines, Theresa A. Guise. Tumor-Bone Cell Interactions in Bone Metastases. In: Bone Cancer. Elsevier, 2010:9-40.
     

211. 211

     Shinsuke Kido, Rika Kuriwaka-Kido, Takeshi Imamura, Yuji Ito, Daisuke Inoue, Toshio Matsumoto. (2009) Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. Bone 45:6, 1125-1132
     

212. 212

     Wendy Mak, Xinyu Shao, Colin R. Dunstan, Markus J. Seibel, Hong Zhou. (2009) Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International 85:6, 538-545
     

213. 213

     Richard J. Murrills, Jeanne J. Matteo, Bheem M. Bhat, Valerie E. Coleburn, Kristina M. Allen, Wei Chen, Veronique Damagnez, Ramesh A. Bhat, Frederick J. Bex, Peter V.N. Bodine. (2009) A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V). Journal of Cellular Biochemistry 108:5, 1066-1075
     

214. 214

     Gerard Karsenty, Henry M. Kronenberg, Carmine Settembre. (2009) Genetic Control of Bone Formation. Annual Review of Cell and Developmental Biology 25:1, 629-648
     

215. 215

     Apostolos I Gogakos, Moira S Cheung, JH Duncan Bassett, Graham R Williams. (2009) Bone signaling pathways and treatment of osteoporosis. Expert Review of Endocrinology & Metabolism 4:6, 639-650
     

216. 216

     Haibin Zhou, Linshan Shang, Xi Li, Xiyu Zhang, Guimin Gao, Chenhong Guo, Bingxi Chen, Qiji Liu, Yaoqin Gong, Changshun Shao. (2009) Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells. Experimental Cell Research 315:17, 2953-2962
     

217. 217

     Kong Wah Ng, T. John Martin. (2009) New functions for old hormones: Bone as an endocrine organ. Molecular and Cellular Endocrinology 310:1-2, 1-2
     

218. 218

     Frances Milat, Kong Wah Ng. (2009) Is Wnt signalling the final common pathway leading to bone formation?. Molecular and Cellular Endocrinology 310:1-2, 52-62
     

219. 219

     Keizo Ohnaka, Ken Yamamoto, Kenjiro Nakamura, Masahiro Adachi, Hisaya Kawate, Suminori Kono, Ryoichi Takayanagi. (2009) Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women. Geriatrics & Gerontology International 9:3, 304-309
     

220. 220

     D. J. Leeming, K. Henriksen, I. Byrjalsen, P. Qvist, S. H. Madsen, P. Garnero, M. A. Karsdal. (2009) Is bone quality associated with collagen age?. Osteoporosis International 20:9, 1461-1470
     

221. 221

     Ni Tang, Wen-Xin Song, Jinyong Luo, Xiaoji Luo, Jin Chen, Katie A. Sharff, Yang Bi, Bai-Cheng He, Jia-Yi Huang, Gao-Hui Zhu, Yu-Xi Su, Wei Jiang, Min Tang, Yun He, Yi Wang, Liang Chen, Guo-Wei Zuo, Jikun Shen, Xiaochuan Pan, Russell R. Reid, Hue H. Luu, Rex C. Haydon, Tong-Chuan He. (2009) BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/β-catenin signalling. Journal of Cellular and Molecular Medicine 13:8b, 2448-2464
     

222. 222

     Jingang Xiao, Hai Dong, Yao Wu, Weidong Tian, Lei Liu. (2009) Gene Expression Profiling of Cx3cl1 in Bone Marrow Mesenchymal Stem Cells by Osteogenic Induction. OMICS: A Journal of Integrative Biology 13:4, 337-343
     

223. 223

     Qiuqian Wu, Jason H. Huang, Erik R. Sampson, Kyung-OK Kim, Michael J. Zuscik, Regis J. O'Keefe, Di Chen, Randy N. Rosier. (2009) Smurf2 induces degradation of GSK-3β and upregulates β-catenin in chondrocytes: A potential mechanism for Smurf2-induced degeneration of articular cartilage. Experimental Cell Research 315:14, 2386-2398
     

224. 224

     Qiming Fan, Tingting Tang, Xiaoling Zhang, Kerong Dai. (2009) The role of CCAAT/enhancer binding protein (C/EBP)-α in osteogenesis of C3H10T1/2 cells induced by BMP-2. Journal of Cellular and Molecular Medicine 13:8b, 2489-2505
     

225. 225

     Michael J. Marshall, Sally F. Evans, Christopher A. Sharp, Diane E. Powell, Helen S. McCarthy, Michael W.J. Davie. (2009) Increased circulating Dickkopf-1 in Paget's disease of bone. Clinical Biochemistry 42:10-11, 965-969
     

226. 226

     M. K. Javaid, N. E. Lane, D. C. Mackey, L.-Y. Lui, N. K. Arden, T. J. Beck, M. C. Hochberg, M. C. Nevitt. (2009) Changes in proximal femoral mineral geometry precede the onset of radiographic hip osteoarthritis: The study of osteoporotic fractures. Arthritis & Rheumatism 60:7, 2028-2036
     

227. 227

     Bryan T. MacDonald, Keiko Tamai, Xi He. (2009) Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell 17:1, 9-26
     

228. 228

     Kim Henriksen, Anita V. Neutzsky-Wulff, Lynda F. Bonewald, Morten A. Karsdal. (2009) Local communication on and within bone controls bone remodeling. Bone 44:6, 1026-1033
     

229. 229

     A. Santos, A. D. Bakker, J. Klein-Nulend. (2009) The role of osteocytes in bone mechanotransduction. Osteoporosis International 20:6, 1027-1031
     

230. 230

     Saila Lappalainen, Anne Saarinen, Pauliina Utriainen, Raimo Voutilainen, Jarmo Jääskeläinen, Outi Mäkitie. (2009) LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children. Clinical Endocrinology 70:5, 725-731
     

231. 231

     Nathalie Voorzanger-Rousselot, Fabrice Journe, Valérie Doriath, Jean-Jacques Body, Patrick Garnero. (2009) Assessment of Circulating Dickkopf-1 with a New Two-Site Immunoassay in Healthy Subjects and Women with Breast Cancer and Bone Metastases. Calcified Tissue International 84:5, 348-354
     

232. 232

     Dominique Leboeuf, Kareen Letellier, Nathalie Alos, Patrick Edery, Florina Moldovan. (2009) Do estrogens impact adolescent idiopathic scoliosis?. Trends in Endocrinology & Metabolism 20:4, 147-152
     

233. 233

     Takuo Kubota, Toshimi Michigami, Keiichi Ozono. (2009) Wnt signaling in bone metabolism. Journal of Bone and Mineral Metabolism 27:3, 265-271
     

234. 234

     Eiji Nemoto, Yohei Koshikawa, Sousuke Kanaya, Masahiro Tsuchiya, Masato Tamura, Martha J. Somerman, Hidetoshi Shimauchi. (2009) Wnt signaling inhibits cementoblast differentiation and promotes proliferation. Bone 44:5, 805-812
     

235. 235

     G. Liu, S. Vijayakumar, L. Grumolato, R. Arroyave, H. Qiao, G. Akiri, S. A. Aaronson. (2009) Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. The Journal of Cell Biology 185:1, 67-75
     

236. 236

     Alison F. Doubleday, Frederika A. Kaestle, Laura A. Cox, Shifra Birnbaum, Michael C. Mahaney, Lorena M. Havill. (2009) LRP5 sequence and polymorphisms in the baboon. Journal of Medical Primatology 38:2, 97-106
     

237. 237

     N. Maruotti, A. Corrado, M. Grano, S. Colucci, F. P. Cantatore. (2009) Normal and osteoporotic human osteoblast behaviour after 1,25-dihydroxy-vitamin D3 stimulation. Rheumatology International 29:6, 667-672
     

238. 238

     Maya Kansara, Michael Tsang, Laurent Kodjabachian, Natalie A. Sims, Melanie K. Trivett, Mathias Ehrich, Alexander Dobrovic, John Slavin, Peter F.M. Choong, Paul J. Simmons, Igor B. Dawid, David M. Thomas. (2009) Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. Journal of Clinical Investigation 119:4, 837-851
     

239. 239

     P. J. Marie. (2009) N-Cadherin-Wnt Connections and the Control of Bone Formation. IBMS BoneKEy 6:4, 150-156
     

240. 240

     Sylvie Giroux, François Rousseau. (2009) Genes and osteoporosis: time for a change in strategy. International Journal of Clinical Rheumatology 4:2, 221-233
     

241. 241

     Frank P. Luyten, Przemko Tylzanowski, Rik J. Lories. (2009) Wnt signaling and osteoarthritis. Bone 44:4, 522-527
     

242. 242

     Young Ho Lee, Jin-Hyun Woo, Seong Jae Choi, Jong Dae Ji, Gwan Gyu Song. (2009) Association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene and bone mineral density: a meta-analysis. Rheumatology International 29:5, 539-544
     

243. 243

     Marcin Kruk, Stuart H. Ralston, Omar M. E. Albagha. (2009) LRP5 Polymorphisms and Response to Risedronate Treatment in Osteoporotic Men. Calcified Tissue International 84:3, 171-179
     

244. 244

     Yan Chen, Benjamin A. Alman. (2009) Wnt pathway, an essential role in bone regeneration. Journal of Cellular Biochemistry 106:3, 353-362
     

245. 245

     Clifford J Rosen. (2009) Breaking into bone biology: serotonin's secrets. Nature Medicine 15:2, 145-146
     

246. 246

     R. Baron. (2009) Wnt Signaling, LRP5 and Gut Serotonin: Have We Been Targeting the Right Pathway for the Wrong Reasons?. IBMS BoneKEy 6:2, 86-93
     

247. 247

     Lionel Lim. Osteoporosis in men. In: Men's Health, Third Edition. CRC Press, 2009:299-313.
     

248. 248

     J. J. Pinzone, B. M. Hall, N. K. Thudi, M. Vonau, Y.-W. Qiang, T. J. Rosol, J. D. Shaughnessy. (2009) The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood 113:3, 517-525
     

249. 249

     Jean-Philippe Rey, Debra L. Ellies. (2009) Wnt modulators in the biotech pipeline. Developmental Dynamicsn/a-n/a
     

250. 250

     Justus H.W. Jansen, Marco Eijken, Holger Jahr, Hideki Chiba, Jan A.N. Verhaar, Johannes P.T.M. van Leeuwen, Harrie Weinans. (2009) Stretch-induced inhibition of Wnt/β-catenin signaling in mineralizing osteoblasts. Journal of Orthopaedic Researchn/a-n/a
     

251. 251

     Ramesh A. Bhat, Barbara Stauffer, Anthony Della Pietra, Peter V.N. Bodine. (2009) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. Journal of Cellular Biochemistryn/a-n/a
     

252. 252

     Tomohiko URANO, Masataka SHIRAKI, Takahiko USUI, Noriko SASAKI, Yasuyoshi OUCHI, Satoshi INOUE. (2009) A1330V Variant of the Low-density Lipoprotein Receptorrelated Protein 5 (LRP5) Gene Decreases Wnt Signaling and Affects the Total Body Bone Mineral Density in Japanese Women. Endocrine Journal 56:4, 625-631
     

253. 253

     T. Segovia-Silvestre, A. V. Neutzsky-Wulff, M. G. Sorensen, C. Christiansen, J. Bollerslev, M. A. Karsdal, K. Henriksen. (2009) Advances in osteoclast biology resulting from the study of osteopetrotic mutations. Human Genetics 124:6, 561-577
     

254. 254

     Nobue Itasaki, Stefan Hoppler. (2009) Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship. Developmental DynamicsNA-NA
     

255. 255

     Zandra A Jenkins, Margriet van Kogelenberg, Tim Morgan, Aaron Jeffs, Ryuji Fukuzawa, Esther Pearl, Christina Thaller, Anne V Hing, Mary E Porteous, Sixto Garcia-Miñaur, Axel Bohring, Didier Lacombe, Fiona Stewart, Torunn Fiskerstrand, Laurence Bindoff, Siren Berland, Lesley C Adès, Michel Tchan, Albert David, Louise C Wilson, Raoul C M Hennekam, Dian Donnai, Sahar Mansour, Valérie Cormier-Daire, Stephen P Robertson. (2009) Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics 41:1, 95-100
     

256. 256

     Toru Ishibe, Tetsuya Goto, Kentaro Kawata, Shigeru Kobayashi, Tetsu Takahashi. (2009) The Expression of Apolipoprotein E in Osteoblastic Cells on Titanium. The Journal of the Kyushu Dental Society 63:2, 78-86
     

257. 257

     Nancy E. Lane. Metabolic Bone Disease. In: Kelley's Textbook of Rheumatology. Elsevier, 2009:1579-1599.
     

258. 258

     Janet E. Rubin, Clinton T. Rubin. Biology, Physiology, and Morphology of Bone. In: Kelley's Textbook of Rheumatology. Elsevier, 2009:71-91.
     

259. 259

     Richard P. Lifton, Lynn M. Boyden. Genetic Approaches to Human Disease. In: Genetic Diseases of the Kidney. Elsevier, 2009:3-24.
     

260. 260

     GuangJun Zhang, B. Frank Eames, Martin J. Cohn. Chapter 2 Evolution of Vertebrate Cartilage Development. Elsevier, 2009:15-42.
     

261. 261

     Tuan V Nguyen, Jacqueline R Center, John A Eisman. (2008) Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapy. Current Opinion in Endocrinology, Diabetes and Obesity 15:6, 481-488
     

262. 262

     Brian L. Foster, Kevin A. Tompkins, R. Bruce Rutherford, Hai Zhang, Emily Y. Chu, Hanson Fong, Martha J. Somerman. (2008) Phosphate: Known and potential roles during development and regeneration of teeth and supporting structures. Birth Defects Research Part C: Embryo Today: Reviews 84:4, 281-314
     

263. 263

     Lídia Agueda, Mariona Bustamante, Susana Jurado, Natalia Garcia-Giralt, Manel Ciria, Guillem Saló, Ramon Carreras, Xavier Nogués, Leonardo Mellibovsky, Adolfo Díez-Pérez, Daniel Grinberg, Susana Balcells. (2008) A Haplotype-Based Analysis of the LRP5 Gene in Relation to Osteoporosis Phenotypes in Spanish Postmenopausal Women. Journal of Bone and Mineral Research 23:12, 1954-1963
     

264. 264

     Yeon Jeong Kim, Jong Tae Kim, Yong Chan Bae, Kuen Taek Suh, Jin Sup Jung. (2008) ICAT participates in proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cell. Life Sciences 83:25-26, 851-858
     

265. 265

     Bram Perdu, Wim Hul, Liesbeth Wesenbeeck. (2008) Osteopetrosis: from Animal Models to Human Conditions. Clinical Reviews in Bone and Mineral Metabolism 6:3-4, 71-81
     

266. 266

     F. Timo Beil, Sebastian Seitz, Mathias Priemel, Florian Barvencik, Christoph Domarus, Johannes M. Rueger, Michael Amling, Pia Pogoda. (2008) Pathophysiology and Pathomorphology of Osteoporosis. European Journal of Trauma and Emergency Surgery 34:6, 527-534
     

267. 267

     Vijay K. Yadav, Je-Hwang Ryu, Nina Suda, Kenji F. Tanaka, Jay A. Gingrich, Günther Schütz, Francis H. Glorieux, Cherie Y. Chiang, Jeffrey D. Zajac, Karl L. Insogna, J. John Mann, Rene Hen, Patricia Ducy, Gerard Karsenty. (2008) Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum. Cell 135:5, 825-837
     

268. 268

     Fanxin Long. (2008) When the Gut Talks to Bone. Cell 135:5, 795-796
     

269. 269

     Serge Ferrari. (2008) Human genetics of osteoporosis. Best Practice & Research Clinical Endocrinology & Metabolism 22:5, 723-735
     

270. 270

     Maripat Corr. (2008) Wnt–β-catenin signaling in the pathogenesis of osteoarthritis. Nature Clinical Practice Rheumatology 4:10, 550-556
     

271. 271

     P. Leucht, S. Minear, D. Ten Berge, R. Nusse, J.A. Helms. (2008) Translating insights from development into regenerative medicine: The function of Wnts in bone biology. Seminars in Cell & Developmental Biology 19:5, 434-443
     

272. 272

     T. John Martin, Ego Seeman. (2008) Bone remodelling: its local regulation and the emergence of bone fragility. Best Practice & Research Clinical Endocrinology & Metabolism 22:5, 701-722
     

273. 273

     J.M. Kerkhof, A.G. Uitterlinden, A.M. Valdes, D.J. Hart, F. Rivadeneira, M. Jhamai, A. Hofman, H.A.P. Pols, S.M.A. Bierma-Zeinstra, T.D. Spector, J.B. van Meurs. (2008) Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis and Cartilage 16:10, 1141-1149
     

274. 274

     Christopher M. Amantea, Woo-Kyun Kim, Vicente Meliton, Sotirios Tetradis, Farhad Parhami. (2008) Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling. Journal of Cellular Biochemistry 105:2, 424-436
     

275. 275

     Takuo Kubota, Toshimi Michigami, Naoko Sakaguchi, Chikara Kokubu, Akira Suzuki, Noriyuki Namba, Norio Sakai, Shigeo Nakajima, Kenji Imai, Keiichi Ozono. (2008) Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd. Journal of Bone and Mineral Research 23:10, 1661-1671
     

276. 276

     D. Karasik, S. L. Ferrari. (2008) Contribution of Gender-Specific Genetic Factors to Osteoporosis Risk. Annals of Human Genetics 72:5, 696-714
     

277. 277

     Kevin Chen, Shannon Fallen, Hatice Özel Abaan, Mutlu Hayran, Corina Gonzalez, Felasfa Wodajo, Tobey MacDonald, Jeffrey A. Toretsky, Aykut Üren. (2008) Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. Pediatric Blood & Cancer 51:3, 349-355
     

278. 278

     Elizabeth A. Streeten, Daniel McBride, Eric Puffenberger, Marc E. Hoffman, Toni I. Pollin, Patrick Donnelly, Paul Sack, Holmes Morton. (2008) Osteoporosis-pseudoglioma syndrome: Description of 9 new cases and beneficial response to bisphosphonates. Bone 43:3, 584-590
     

279. 279

     T. J. Martin, N. A. Sims, K. W. Ng. (2008) Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis. Osteoporosis International 19:8, 1125-1138
     

280. 280

     José M. López, Wendy Balemans, Elke Piters, Wim Van Hul, Gilberto González. (2008) Genetic analysis and effect of triiodothyronine and prednisone trial on bone turnover in a patient with craniotubular hyperostosis. Bone 43:2, 405-409
     

281. 281

     Y.-W. Qiang, J. D. Shaughnessy, S. Yaccoby. (2008) Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood 112:2, 374-382
     

282. 282

     Ryan Himes, Frederick H. Wezeman, John J. Callaci. (2008) Identification of Novel Bone-Specific Molecular Targets of Binge Alcohol and Ibandronate by Transcriptome Analysis. Alcoholism: Clinical and Experimental Research 32:7, 1167-1180
     

283. 283

     K. M. Middleton, S. A. Kelly, T. Garland. (2008) Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice. Integrative and Comparative Biology 48:3, 394-410
     

284. 284

     Valerie S. Salazar, Gabriel Mbalaviele, Roberto Civitelli. (2008) The pro-osteogenic action of β-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity. Journal of Cellular Biochemistry 104:3, 942-952
     

285. 285

     Claire M. Edwards, Junling Zhuang, Gregory R. Mundy. (2008) The pathogenesis of the bone disease of multiple myeloma. Bone 42:6, 1007-1013
     

286. 286

     Wendy Balemans, Elke Piters, Erna Cleiren, Minrong Ai, Liesbeth Wesenbeeck, Matthew L. Warman, Wim Hul. (2008) The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations. Calcified Tissue International 82:6, 445-453
     

287. 287

     E. Grundberg, E. M. Lau, M. Lorentzson, M. Karlsson, A. Holmberg, L. Groop, D. Mellström, E. Orwoll, H. Mallmin, C. Ohlsson, Ö. Ljunggren, K. Åkesson. (2008) Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. Osteoporosis International 19:6, 829-837
     

288. 288

     Carmen E. Macsai, Bruce K. Foster, Cory J. Xian. (2008) Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair. Journal of Cellular Physiology 215:3, 578-587
     

289. 289

     Sonja Herman, Gerhard Krönke, Georg Schett. (2008) Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends in Molecular Medicine 14:6, 245-253
     

290. 290

     Xiaodong Li, Michael S Ominsky, Qing-Tian Niu, Ning Sun, Betsy Daugherty, Diane D'Agostin, Carole Kurahara, Yongming Gao, Jin Cao, Jianhua Gong, Frank Asuncion, Mauricio Barrero, Kelly Warmington, Denise Dwyer, Marina Stolina, Sean Morony, Ildiko Sarosi, Paul J Kostenuik, David L Lacey, W Scott Simonet, Hua Zhu Ke, Chris Paszty. (2008) Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength. Journal of Bone and Mineral Research 23:6, 860-869
     

291. 291

     T. V. Nguyen. (2008) Genetics of Osteoporosis: From Population Association to Individualized Prognosis of Fracture. IBMS BoneKEy 5:6, 212-221
     

292. 292

     M. Eijken, I.M.J. Meijer, I. Westbroek, M. Koedam, H. Chiba, A.G. Uitterlinden, H.A.P. Pols, J.P.T.M. van Leeuwen. (2008) Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner. Journal of Cellular Biochemistry 104:2, 568-579
     

293. 293

     Akira Suzuki, Keiichi Ozono, Takuo Kubota, Hiroki Kondou, Kanako Tachikawa, Toshimi Michigami. (2008) PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3β in osteoblastic Saos-2 cells. Journal of Cellular Biochemistry 104:1, 304-317
     

294. 294

     Joseph M Zmuda, Candace M Kammerer. (2008) Snipping away at osteoporosis susceptibility. The Lancet 371:9623, 1479-1480
     

295. 295

     A. Hofmann, U. Ritz, M.H. Hessmann, C. Schmid, A. Tresch, J.D. Rompe, A. Meurer, P.M. Rommens. (2008) Cell viability, osteoblast differentiation, and gene expression are altered in human osteoblasts from hypertrophic fracture non-unions. Bone 42:5, 894-906
     

296. 296

     B. Espina Riera, J. González-Macías. (2008) Patogenia de la osteoporosis esteroidea. Revista Española de Enfermedades Metabólicas Óseas 17:3, 44-48
     

297. 297

     Elke Piters, Eveline Boudin, Wim Van Hul. (2008) Wnt signaling: A win for bone. Archives of Biochemistry and Biophysics 473:2, 112-116
     

298. 298

     Nathalie Leclerc, Tommy Noh, Jon Cogan, Dilan B. Samarawickrama, Elisheva Smith, Baruch Frenkel. (2008) Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures. Journal of Cellular Biochemistry 103:6, 1938-1951
     

299. 299

     T Nakamura, T Nakamura, K Matsumoto. (2008) The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology. Journal of Cellular and Molecular Medicine 12:2, 391-408
     

300. 300

     Ya-Wei Qiang, Bart Barlogie, Stuart Rudikoff, John D. Shaughnessy. (2008) Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 42:4, 669-680
     

301. 301

     Lynda F. Bonewald, Mark L. Johnson. (2008) Osteocytes, mechanosensing and Wnt signaling. Bone 42:4, 606-615
     

302. 302

     Qiuqian Wu, Di Chen, Michael J Zuscik, Regis J O'Keefe, Randy N Rosier. (2008) Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of β-Catenin. Journal of Bone and Mineral Research 23:4, 552-563
     

303. 303

     Christian Jorgensen, Farida Djouad, Carine Bouffi, Dominique Mrugala, Danièle Noël. (2008) Multipotent mesenchymal stromal cells in articular diseases. Best Practice & Research Clinical Rheumatology 22:2, 269-284
     

304. 304

     Marie-Christine de Vernejoul. (2008) Sclerosing bone disorders. Best Practice & Research Clinical Rheumatology 22:1, 71-83
     

305. 305

     C. M. Edwards, J. R. Edwards, S. T. Lwin, J. Esparza, B. O. Oyajobi, B. McCluskey, S. Munoz, B. Grubbs, G. R. Mundy. (2008) Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood 111:5, 2833-2842
     

306. 306

     Y.-W. Qiang, Y. Chen, O. Stephens, N. Brown, B. Chen, J. Epstein, B. Barlogie, J. D. Shaughnessy. (2008) Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 112:1, 196-207
     

307. 307

     Peter V N Bodine. (2008) Wnt signaling control of bone cell apoptosis. Cell Research 18:2, 248-253
     

308. 308

     Paul S. Issack, David L. Helfet, Joseph M. Lane. (2008) Role of Wnt Signaling in Bone Remodeling and Repair. HSS Journal 4:1, 66-70
     

309. 309

     Y Jayasinghe, SR Grover, M Zacharin. (2008) Current concepts in bone and reproductive health in adolescents with anorexia nervosa. BJOG: An International Journal of Obstetrics and Gynaecology 115:3, 304-315
     

310. 310

     Gun-Il Im. (2008) Intracellular Signal Transduction Pathways and Transcription Factors for Osteogenesis. The Journal of the Korean Rheumatism Association 15:1, 1
     

311. 311

     Thierry Thomas, Aline Martin. (2008) Formation osseuse, facteurs de régulation. Journal de la Société de Biologie 202:4, 257-264
     

312. 312

     Mark H. Bilsky, Syed Azeem. (2008) Multiple Myeloma: Primary Bone Tumor with Systemic Manifestations. Neurosurgery Clinics of North America 19:1, 31-40
     

313. 313

     Lan-Juan Zhao, Hui Jiang, Christopher J Papasian, Dev Maulik, Betty Drees, James Hamilton, Hong-Wen Deng. (2008) Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis. Journal of Bone and Mineral Research 23:1, 17-29
     

314. 314

     ALLEN W. ROOT, FRANK B. DIAMOND. Disorders of Mineral Homeostasis in the Newborn, Infant, Child, and Adolescent. In: Pediatric Endocrinology. Elsevier, 2008:686-769.
     

315. 315

     Rutger L. van Bezooijen, Socrates E. Papapoulos, Neveen A.T. Hamdy, Clemens W.G.M. Löwik. SOST/Sclerostin. In: Principles of Bone Biology. Elsevier, 2008:139-152.
     

316. 316

     Mark L. Johnson. Wnt Signaling and Bone. In: Principles of Bone Biology. Elsevier, 2008:121-137.
     

317. 317

     Stuart H. Ralston. Genetic Determinants of Bone Mass and Osteoporotic Fracture. In: Principles of Bone Biology. Elsevier, 2008:1611-1634.
     

318. 318

     Thorsten Schinke, Gerard Karsenty. Transcriptional Control of Osteoblast Differentiation and Function. In: Principles of Bone Biology. Elsevier, 2008:109-119.
     

319. 319

     T. Thomas, A. Martin, M.-H. Lafage-Proust. (2008) Physiologie du tissu osseux. EMC - Appareil locomoteur 3:1, 1-16
     

320. 320

     Nalini H. Kulkarni, Tao Wei, Amar Kumar, Ernst R. Dow, Trent R. Stewart, Jianyong Shou, Mathias N'cho, Diane L. Sterchi, Bruce D. Gitter, Richard E. Higgs, David L. Halladay, Thomas A. Engler, T. John Martin, Henry U. Bryant, Yanfei L. Ma, Jude E. Onyia. (2007) Changes in Osteoblast, Chondrocyte, and Adipocyte Lineages Mediate the Bone Anabolic Actions of PTH and Small Molecule GSK-3 Inhibitor. Journal of Cellular Biochemistry 102:6, 1504-1518
     

321. 321

     Christina N Bennett, Hongjiao Ouyang, Yanfei L Ma, Qingqiang Zeng, Isabelle Gerin, Kyle M Sousa, Timothy F Lane, Venkatesh Krishnan, Kurt D Hankenson, Ormond A MacDougald. (2007) Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation. Journal of Bone and Mineral Research 22:12, 1924-1932
     

322. 322

     L. E. Lanyon, V. J. Armstrong, L. K. Saxon, A. Sunters, T. Sugiyama, G. Zaman, J. S. Price. (2007) Estrogen Receptors Critically Regulate Bones’ Adaptive Responses to Loading. Clinical Reviews in Bone and Mineral Metabolism 5:4, 234-248
     

323. 323

     K. Brixen, S. Beckers, A. Peeters, E. Piters, W. Balemans, T. L. Nielsen, K. Wraae, L. Bathum, C. Brasen, C. Hagen, M. Andersen, W. Hul, B. Abrahamsen. (2007) Polymorphisms in the Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5) Gene Are Associated with Peak Bone Mass in Non-sedentary Men: Results from the Odense Androgen Study. Calcified Tissue International 81:6, 421-429
     

324. 324

     Fernando Anjos-Afonso, Dominique Bonnet. (2007) Flexible and dynamic organization of bone marrow stromal compartment. British Journal of Haematology 139:3, 373-384
     

325. 325

     Weimin Qiu, Tom E Andersen, Jens Bollerslev, Susanne Mandrup, Basem M Abdallah, Moustapha Kassem. (2007) Patients With High Bone Mass Phenotype Exhibit Enhanced Osteoblast Differentiation and Inhibition of Adipogenesis of Human Mesenchymal Stem Cells. Journal of Bone and Mineral Research 22:11, 1720-1731
     

326. 326

     T. J. Martin, K. W. Ng. (2007) New Agents for the Treatment of Osteoporosis. International Bone and Mineral Society Knowledge Environment 4:11, 287-298
     

327. 327

     Nancy E. Lane, Michael C. Nevitt, Li-Yung Lui, Patricia de Leon, Maripat Corr, . (2007) Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis & Rheumatism 56:10, 3319-3325
     

328. 328

     S. Kato, R. Fujiki. (2007) Is Estrogen Receptor   an Osteoblastic Mechanosensor?. International Bone and Mineral Society Knowledge Environment 4:10, 273-277
     

329. 329

     N Voorzanger-Rousselot, D Goehrig, F Journe, V Doriath, J J Body, P Clézardin, P Garnero. (2007) Increased Dickkopf-1 expression in breast cancer bone metastases. British Journal of Cancer
     

330. 330

     Yeşim Gökçe-Kutsal, Levent Özçakar, Nurten Eskiyurt, Merih Eryavuz, Katarzyna Gruszecka-Marczynska, Mohammed Mehdie Emam, Nigar Dursun, Ebru Korap, Anıl Barak, Anıl Aktaş, Ergun Karaağaoğlu. (2007) Epidemiological multicenter study on osteoporosis: the EDMUSTO study. Rheumatology International 27:12, 1189-1191
     

331. 331

     Y. Suwazono, E. Kobayashi, M. Dochi, K. Miura, Y. Morikawa, M. Ishizaki, T. Kido, H. Nakagawa, K. Nogawa. (2007) Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia. Clinical and Experimental Medicine 7:3, 108-114
     

332. 332

     Michael J Nemeth, David M Bodine. (2007) Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways. Cell Research 17:9, 746-758
     

333. 333

     Bryan T. MacDonald, Danese M. Joiner, Sivan M. Oyserman, Parul Sharma, Steven A. Goldstein, Xi He, Peter V. Hauschka. (2007) Bone mass is inversely proportional to Dkk1 levels in mice. Bone 41:3, 331-339
     

334. 334

     Canalis , Ernesto , Giustina , Andrea , Bilezikian , John P. , . (2007) Mechanisms of Anabolic Therapies for Osteoporosis. New England Journal of Medicine 357:9, 905-916
     Full Text

335. 335

     Dolores Baksh, Genevieve M. Boland, Rocky S. Tuan. (2007) Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. Journal of Cellular Biochemistry 101:5, 1109-1124
     

336. 336

     Christian Köhler, Olav M. Andersen, Annette Diehl, Gerd Krause, Peter Schmieder, Hartmut Oschkinat. (2007) The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. Journal of Structural and Functional Genomics 7:3-4, 131-138
     

337. 337

     M. Audrey Koay, Jonathan H. Tobias, Sam D. Leary, Colin D. Steer, Carles Vilariño-Güell, Matthew A. Brown. (2007) The Effect of LRP5 Polymorphisms on Bone Mineral Density Is Apparent in Childhood. Calcified Tissue International 81:1, 1-9
     

338. 338

     Lawrence G. Raisz. (2007) The osteoporosis revolution marches on. Journal of Orthopaedic Science 12:4, 405-412
     

339. 339

     Mark L Johnson, Mohamed A Kamel. (2007) The Wnt signaling pathway and bone metabolism. Current Opinion in Rheumatology 19:4, 376-382
     

340. 340

     Yan-chuan Shi, Leah Worton, Luis Esteban, Paul Baldock, Colette Fong, John A. Eisman, Edith M. Gardiner. (2007) Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation. Bone 41:1, 87-96
     

341. 341

     Struan FA Grant, Hakon Hakonarson. (2007) Recent development in pharmacogenomics: from candidate genes to genome-wide association studies. Expert Review of Molecular Diagnostics 7:4, 371-393
     

342. 342

     Tomohiko Urano, Ken'ichiro Narusawa, Masataka Shiraki, Takahiko Usui, Noriko Sasaki, Takayuki Hosoi, Yasuyoshi Ouchi, Toshitaka Nakamura, Satoshi Inoue. (2007) Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. Journal of Bone and Mineral Metabolism 25:4, 253-258
     

343. 343

     Roland Baron, Georges Rawadi. (2007) Wnt signaling and the regulation of bone mass. Current Osteoporosis Reports 5:2, 73-80
     

344. 344

     Wendy Balemans, Jean-Pierre Devogelaer, Erna Cleiren, Elke Piters, Emanuelle Caussin, Wim Van Hul. (2007) Novel LRP5 Missense Mutation in a Patient With a High Bone Mass Phenotype Results in Decreased DKK1-Mediated Inhibition of Wnt Signaling*. Journal of Bone and Mineral Research 22:5, 708-716
     

345. 345

     Lawrence G. Raisz. (2007) Maintaining the life-long vitality and integrity of skeletal tissue. Bone 40:5, S1-S4
     

346. 346

     Sylvie Giroux, Latifa Elfassihi, Guy Cardinal, Nathalie Laflamme, François Rousseau. (2007) LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women. Bone 40:5, 1299-1307
     

347. 347

     Morten A Karsdal, Thomas J Martin, Jens Bollerslev, Claus Christiansen, Kim Henriksen. (2007) Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?. Journal of Bone and Mineral Research 22:4, 487-494
     

348. 348

     Bheem M. Bhat, Kristina M. Allen, Wei Liu, James Graham, Art Morales, Anthony Anisowicz, Ho-Sun Lam, Catherine McCauley, Valerie Coleburn, Michael Cain, Eric Fortier, Ramesh A. Bhat, Frederick J. Bex, Paul J. Yaworsky. (2007) Structure-based mutation analysis shows the importance of LRP5 β-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling. Gene 391:1-2, 103-112
     

349. 349

     Yoichi Ezura, Toshiaki Nakajima, Tomohiko Urano, Yoshihiro Sudo, Mitsuko Kajita, Hideyo Yoshida, Takao Suzuki, Takayuki Hosoi, Satoshi Inoue, Masataka Shiraki, Mitsuru Emi. (2007) Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women. Bone 40:4, 997-1005
     

350. 350

     Anne Saarinen, Ville-Valtteri Välimäki, Matti J. Välimäki, Eliisa Löyttyniemi, Kirsi Auro, Piia Uusen, Mairi Kuris, Anna-Elina Lehesjoki, Outi Mäkitie. (2007) The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men. Bone 40:4, 1006-1012
     

351. 351

     Douglas P. Kiel, Serge L. Ferrari, L. Adrienne Cupples, David Karasik, Danielle Manen, Alma Imamovic, Alan G. Herbert, Josée Dupuis. (2007) Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. Bone 40:3, 587-596
     

352. 352

     Jackie A. Fretz, Lee A. Zella, Sungtae Kim, Nirupama K. Shevde, J. Wesley Pike. (2007) 1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site. The Journal of Steroid Biochemistry and Molecular Biology 103:3-5, 440-445
     

353. 353

     Takahiko Usui, Tomohiko Urano, Masataka Shiraki, Yasuyoshi Ouchi, Satoshi Inoue. (2007) Association of a single nucleotide polymorphism in Wnt10bgene with bone mineral density. Geriatrics & Gerontology International 7:1, 48-53
     

354. 354

     J. Wesley Pike, Mark B. Meyer, Makoto Watanuki, Sungtae Kim, Lee A. Zella, Jackie A. Fretz, Miwa Yamazaki, Nirupama K. Shevde. (2007) Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor. The Journal of Steroid Biochemistry and Molecular Biology 103:3-5, 389-395
     

355. 355

     Peter V Bodine. (2007) Wnt signaling in bone. BoneKEy-Osteovision 4:3, 108-123
     

356. 356

     Urszula T Iwaniec, Thomas J Wronski, Jeff Liu, Mercedes F Rivera, Rosemarie R Arzaga, Gwenn Hansen, Robert Brommage. (2007) PTH Stimulates Bone Formation in Mice Deficient in Lrp5. Journal of Bone and Mineral Research 22:3, 394-402
     

357. 357

     Dong-Hai Xiong, Shu-Feng Lei, Fang Yang, Liang Wang, Yu-Mei Peng, Wei Wang, Robert R Recker, Hong-Wen Deng. (2007) Low-Density Lipoprotein Receptor-Related Protein 5 ( LRP5 ) Gene Polymorphisms Are Associated With Bone Mass in Both Chinese and Whites. Journal of Bone and Mineral Research 22:3, 385-393
     

358. 358

     Peter V.N. Bodine, Laura Seestaller-Wehr, Yogendra P. Kharode, Frederick J. Bex, Barry S. Komm. (2007) Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1. Journal of Cellular Physiology 210:2, 352-357
     

359. 359

     Feng-Sheng Wang, Jih-Yang Ko, Chun-Liang Lin, Hsing-Long Wu, Huei-Jin Ke, Pei-Ju Tai. (2007) Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats. Bone 40:2, 485-492
     

360. 360

     Steven R Goldring, Mary B Goldring. (2007) Eating bone or adding it: the Wnt pathway decides. Nature Medicine 13:2, 133-134
     

361. 361

     Dorit Naot, Usha Bava, Brya Matthews, Karen E Callon, Gregory D Gamble, Michael Black, Sarah Song, Rocco P Pitto, Tim Cundy, Jill Cornish, Ian R Reid. (2007) Differential Gene Expression in Cultured Osteoblasts and Bone Marrow Stromal Cells From Patients With Paget's Disease of Bone. Journal of Bone and Mineral Research 22:2, 298-309
     

362. 362

     Paul Polakis. (2007) The many ways of Wnt in cancer. Current Opinion in Genetics & Development 17:1, 45-51
     

363. 363

     Jinyong Luo, Jin Chen, Zhong-Liang Deng, Xiaoji Luo, Wen-Xin Song, Katie A Sharff, Ni Tang, Rex C Haydon, Hue H Luu, Tong-Chuan He. (2007) Wnt signaling and human diseases: what are the therapeutic implications?. Laboratory Investigation 87:2, 97-103
     

364. 364

     Neeraj Kumar Satija, G.U. Gurudutta, Shilpa Sharma, Farhat Afrin, Pallavi Gupta, Yogesh Kumar Verma, Vimal Kishor Singh, R.P. Tripathi. (2007) Mesenchymal Stem Cells: Molecular Targets for Tissue Engineering. Stem Cells and Development 16:1, 7-24
     

365. 365

     Mark L. Johnson, Nalini Rajamannan. (2007) Diseases of Wnt signaling. Reviews in Endocrine and Metabolic Disorders 7:1-2, 41-49
     

366. 366

     Jane B. Lian, Gary S. Stein, Amjad Javed, Andre J. Wijnen, Janet L. Stein, Martin Montecino, Mohammad Q. Hassan, Tripti Gaur, Christopher J. Lengner, Daniel W. Young. (2007) Networks and hubs for the transcriptional control of osteoblastogenesis. Reviews in Endocrine and Metabolic Disorders 7:1-2, 1-16
     

367. 367

     Aiko Nakashima, Masayuki Nashimoto, Masato Tamura. (2007) TRUE Gene Silencing: Unique Gene Silencing by the tRNA Maturase tRNase ZL under the Direction of Small-guide RNA. Journal of Oral Biosciences 49:1, 54-64
     

368. 368

     Ruth Schwaninger, Cyrill A. Rentsch, Antoinette Wetterwald, Geertje van der Horst, Rutger L. van Bezooijen, Gabri van der Pluijm, Clemens W.G.M. Löwik, Karin Ackermann, Walter Pyerin, Freddie C. Hamdy, George N. Thalmann, Marco G. Cecchini. (2007) Lack of Noggin Expression by Cancer Cells Is a Determinant of the Osteoblast Response in Bone Metastases. The American Journal of Pathology 170:1, 160-175
     

369. 369

     Nicola Giuliani, Vittorio Rizzoli. (2007) Myeloma cells and bone marrow osteoblast interactions: Role in the development of osteolytic lesions in multiple myeloma. Leukemia & Lymphoma 48:12, 2323-2329
     

370. 370

     Se Hwa Kim, Juan Ji An, Yumie Rhee, Sung-Kil Lim. (2007) Identification and Validation of the Relationship of the Anabolic Effect of Parathyroid Hormone with the Wnt/β-catenin Canonical Pathway. Journal of Korean Endocrine Society 22:6, 411
     

371. 371

     J. Guo, L.F. Cooper. (2007) Influence of an LRP5 cytoplasmic SNP on Wnt signaling and osteoblastic differentiation. Bone 40:1, 57-67
     

372. 372

     Dong Jin Chung, Min Young Chung. (2007) Bone Forming Effect of PTH through Wnt/β-catenin Signaling System. Journal of Korean Endocrine Society 22:6, 407
     

373. 373

     Tomohiko Urano, Masataka Shiraki, Ken??ichiro Narusawa, Takahiko Usui, Noriko Sasaki, Takayuki Hosoi, Yasuyoshi Ouchi, Toshitaka Nakamura, Satoshi Inoue. (2007) Q89R Polymorphism in the LDL Receptor-Related Protein 5 Gene Is Associated With Spinal Osteoarthritis in Postmenopausal Japanese Women. Spine 32:1, 25-29
     

374. 374

     Rutger L van Bezooijen, J Peter Svensson, Daniël Eefting, Annemieke Visser, Geertje van der Horst, Marcel Karperien, Paul HA Quax, Harry Vrieling, Socrates E Papapoulos, Peter ten Dijke, Clemens WGM Löwik. (2007) Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation. Journal of Bone and Mineral Research 22:1, 19-28
     

375. 375

     Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. (2007) The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery. Journal of Pharmacological Sciences 104:4, 293-302
     

376. 376

     Pauline M Camacho, Reina Armamento-Villareal, Michael Kleerekoper. (2007) Postmenopausal osteoporosis: an update on current and future therapeutic options. Expert Review of Endocrinology & Metabolism 2:1, 79-90
     

377. 377

     Xiaolin Tu, Kyu Sang Joeng, Keiichi I. Nakayama, Keiko Nakayama, Jayaraj Rajagopal, Thomas J. Carroll, Andrew P. McMahon, Fanxin Long. (2007) Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation. Developmental Cell 12:1, 113-127
     

378. 378

     U. Smith. (2006) TCF7L2 and type 2 diabetes—we WNT to know. Diabetologia 50:1, 5-7
     

379. 379

     C Niehrs. (2006) Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25:57, 7469-7481
     

380. 380

     M. Michael Cohen Jr.. (2006) The new bone biology: Pathologic, molecular, and clinical correlates. American Journal of Medical Genetics Part A 140A:23, 2646-2706
     

381. 381

     Nick Barker, Hans Clevers. (2006) Mining the Wnt pathway for cancer therapeutics. Nature Reviews Drug Discovery 5:12, 997-1014
     

382. 382

     Serge Ferrari. (2006) Single gene mutations and variations affecting bone turnover and strength: a selective 2006 update. BoneKEy-Osteovision 3:12, 11-29
     

383. 383

     Debra L Ellies, Beth Viviano, John McCarthy, Jean-Philippe Rey, Nobue Itasaki, Scott Saunders, Robb Krumlauf. (2006) Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity. Journal of Bone and Mineral Research 21:11, 1738-1749
     

384. 384

     Omar M.E. Albagha, Stuart H. Ralston. (2006) Genetics and Osteoporosis. Rheumatic Disease Clinics of North America 32:4, 659-680
     

385. 385

     Rika Nakanishi, Motoyuki Shimizu, Masayuki Mori, Haruhiko Akiyama, Shuzo Okudaira, Bungo Otsuki, Maiko Hashimoto, Keiichi Higuchi, Masanori Hosokawa, Tadao Tsuboyama, Takashi Nakamura. (2006) Secreted Frizzled-Related Protein 4 Is a Negative Regulator of Peak BMD in SAMP6 Mice. Journal of Bone and Mineral Research 21:11, 1713-1721
     

386. 386

     Ji Li, Ildiko Sarosi, Russell C. Cattley, James Pretorius, Frank Asuncion, Mario Grisanti, Sean Morony, Stephen Adamu, Zhaopo Geng, Wanrong Qiu, Paul Kostenuik, David L. Lacey, W. Scott Simonet, Brad Bolon, Xueming Qian, Victoria Shalhoub, Michael S. Ominsky, Hua Zhu Ke, Xiaodong Li, William G. Richards. (2006) Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39:4, 754-766
     

387. 387

     Evangelos Terpos. (2006) Antibodies to dickkopf-1 protein. Expert Opinion on Therapeutic Patents 16:10, 1453-1458
     

388. 388

     M. Priemel, C. Münch, F. T. Beil, H. Ritzel, M. Amling. (2006) Pathophysiologie und Pathomorphologie der Osteoporose. Der Radiologe 46:10, 831-838
     

389. 389

     W.M.W. Cheung, L.Y. Jin, D.K. Smith, P.T. Cheung, E.Y.W. Kwan, L. Low, A.W.C. Kung. (2006) A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene. Bone 39:3, 470-476
     

390. 390

     Katerina Zajickova, Martin Hill, Marketa Vankova, Ivana Zofkova. (2006) Low-density lipoprotein receptor-related protein 5 and vitamin D receptor gene polymorphisms in relation to vitamin D levels in menopause. Clinical Chemistry and Laboratory Medicine 44:9, 1066-1069
     

391. 391

     S. Mathew, M. Davies, R. Lund, G. Saab, K. A. Hruska. (2006) Function and effect of bone morphogenetic protein-7 in kidney bone and the bone-vascular links in chronic kidney disease. European Journal of Clinical Investigation 36:s2, 43-50
     

392. 392

     Etsuko Matsuzaki, Fumi Takahashi-Yanaga, Yoshikazu Miwa, Masato Hirata, Yutaka Watanabe, Noriharu Sato, Sachio Morimoto, Takao Hirofuji, Katsumasa Maeda, Toshiyuki Sasaguri. (2006) Differentiation-Inducing Factor-1 Alters Canonical Wnt Signaling and Suppresses Alkaline Phosphatase Expression in Osteoblast-Like Cell Lines. Journal of Bone and Mineral Research 21:8, 1307-1316
     

393. 393

     Qing-Yang Huang, Annie Wai Chee Kung. (2006) Genetics of osteoporosis. Molecular Genetics and Metabolism 88:4, 295-306
     

394. 394

     Nico Janssens, Michel Janicot, Tim Perera. (2006) The Wnt-dependent signaling pathways as target in oncology drug discovery. Investigational New Drugs 24:4, 263-280
     

395. 395

     David Thomas, Maya Kansara. (2006) Epigenetic modifications in osteogenic differentiation and transformation. Journal of Cellular Biochemistry 98:4, 757-769
     

396. 396

     Kevin Wang, Prashanth Vishwanath, Gabriel S. Eichler, Maisa O. Al-Sebaei, Cory M. Edgar, Thomas A. Einhorn, Temple F. Smith, Louis C. Gerstenfeld. (2006) Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression. Matrix Biology 25:5, 271-281
     

397. 397

     Farida Djouad, Dominique Mrugala, Danièle Noël, Christian Jorgensen. (2006) Engineered mesenchymal stem cells for cartilage repair. Regenerative Medicine 1:4, 529-537
     

398. 398

     Nalini H Kulkarni, Jude E Onyia, QingQiang Zeng, Xioayan Tian, Min Liu, David L Halladay, Charles A Frolik, Thomas Engler, Tao Wei, Aidas Kriauciunas, T John Martin, Masahiko Sato, Henry U Bryant, Yanfei L Ma. (2006) Orally Bioavailable GSK-3α/β Dual Inhibitor Increases Markers of Cellular Differentiation In Vitro and Bone Mass In Vivo. Journal of Bone and Mineral Research 21:6, 910-920
     

399. 399

     Frederic Morvan, Kim Boulukos, Philippe Clément-Lacroix, Sergio Roman Roman, Isabelle Suc-Royer, Béatrice Vayssière, Patrick Ammann, Patrick Martin, Sonia Pinho, Philippe Pognonec, Patrick Mollat, Christof Niehrs, Roland Baron, Georges Rawadi. (2006) Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass. Journal of Bone and Mineral Research 21:6, 934-945
     

400. 400

     R Graham G Russell, Belen Espina, Philippa Hulley. (2006) Bone biology and the pathogenesis of osteoporosis. Current Opinion in Rheumatology 18:Suppl 1, S3-S10
     

401. 401

     Philip Sambrook, Cyrus Cooper. (2006) Osteoporosis. The Lancet 367:9527, 2010-2018
     

402. 402

     Yasushi Suwazono, Etsuko Kobayashi, Mirei Uetani, Katsuyuki Miura, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Koji Nogawa. (2006) G-protein β3 subunit polymorphism C1429T and low-density lipoprotein receptor–related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males—a prospective study over 5 years. Metabolism 55:6, 751-757
     

403. 403

     Jeffrey M. Gimble, Sanjin Zvonic, Z. Elizabeth Floyd, Moustapha Kassem, Mark E. Nuttall. (2006) Playing with bone and fat. Journal of Cellular Biochemistry 98:2, 251-266
     

404. 404

     James Peter Stewart, John D. Shaughnessy. (2006) Role of osteoblast suppression in multiple myeloma. Journal of Cellular Biochemistry 98:1, 1-13
     

405. 405

     Rachel A. Kahler, Mario Galindo, Jane Lian, Gary S. Stein, Andre J. van Wijnen, Jennifer J. Westendorf. (2006) Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. Journal of Cellular Biochemistry 97:5, 969-983
     

406. 406

     Matthew C. Walsh, Nacksung Kim, Yuho Kadono, Jaerang Rho, Soo Young Lee, Joseph Lorenzo, Yongwon Choi. (2006) OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism. Annual Review of Immunology 24:1, 33-63
     

407. 407

     Yasushi Suwazono, Etsuko Kobayashi, Mirei Uetani, Katsuyuki Miura, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Koji Nogawa. (2006) Low-density lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanese males. Life Sciences 78:21, 2475-2479
     

408. 408

     Christopher L. Hall, Sona Kang, Ormond A. MacDougald, Evan T. Keller. (2006) Role of wnts in prostate cancer bone metastases. Journal of Cellular Biochemistry 97:4, 661-672
     

409. 409

     M. Michael Cohen. (2006) Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling. American Journal of Medical Genetics Part A 140A:5, 515-524
     

410. 410

     Christine Hartmann. (2006) A Wnt canon orchestrating osteoblastogenesis. Trends in Cell Biology 16:3, 151-158
     

411. 411

     Toshio Matsumoto, Masahiro Abe. (2006) Myeloma-bone interaction: A vicious cycle. BoneKEy-Osteovision 3:3, 8-14
     

412. 412

     D. Karasik, D. P. Kiel, D. K. Kiely, L. A. Cupples, P. W. F. Wilson, C. J. O’Donnell, D. T. Felson. (2006) Abdominal Aortic Calcification and Exostoses at the Hand and Lumbar Spine: The Framingham Study. Calcified Tissue International 78:1, 1-8
     

413. 413

     Brixen Kim. (2006) New Approaches to the Diagnosis and Treatment of Postmenopausal Osteoporosis. Journal of Korean Endocrine Society 21:2, 91
     

414. 414

     Beata Lecka-Czernik, Larry J. Suva. (2006) Resolving the Two “Bony” Faces of PPAR-γ. PPAR Research 2006, 1-9
     

415. 415

     Qing-Yang Huang, Mandy Y.M. Ng, Ching-Lung Cheung, Vivian Chan, Pak-Chung Sham, Annie W.C. Kung. (2006) Identification of Two Sex-Specific Quantitative Trait Loci in Chromosome 11q for Hip Bone Mineral Density in Chinese. Human Heredity 61:4, 237-243
     

416. 416

     Joyce BJ van Meurs, Fernando Rivadeneira, Mila Jhamai, Wendy Hugens, Albert Hofman, Johannes PTM van Leeuwen, Huibert AP Pols, André G Uitterlinden. (2006) Common Genetic Variation of the Low-Density Lipoprotein Receptor-Related Protein 5 and 6 Genes Determines Fracture Risk in Elderly White Men. Journal of Bone and Mineral Research 21:1, 141-150
     

417. 417

     Jane B. Lian, Gary S. Stein. The Cells of Bone. In: Dynamics of Bone and Cartilage Metabolism. Elsevier, 2006:221-258.
     

418. 418

     Philippa Hulley, Graham Russell, Peter Croucher. Growth Factors. In: Dynamics of Bone and Cartilage Metabolism. Elsevier, 2006:99-113.
     

419. 419

     Roland Baron, Georges Rawadi, Sergio Roman‐Roman. Wnt Signaling: A Key Regulator of Bone Mass. Elsevier, 2006:103-127.
     

420. 420

     Kristen M. Borchert, Rachelle J. Sells Galvin, Laura V. Hale, O. Joseph Trask, Debra R. Nickischer, Keith A. Houck. Screening for Activators of the Wingless Type/Frizzled Pathway by Automated Fluorescent Microscopy. Elsevier, 2006:140-150.
     

421. 421

     Donald A. Glass, Gerard Karsenty. Molecular Bases of the Regulation of Bone Remodeling by the Canonical Wnt Signaling Pathway. Elsevier, 2006:43-84.
     

422. 422

     Janne Pesonen, Joonas Sirola, Marjo Tuppurainen, Jukka Jurvelin, Esko Alhava, Risto Honkanen, Heikki Kr. (2005) High bone mineral density among perimenopausal women. Osteoporosis International 16:12, 1899-1906
     

423. 423

     S.L. Ferrari, S. Deutsch, C. Baudoin, M. Cohen-Solal, A. Ostertag, S.E. Antonarakis, R. Rizzoli, M.C. de Vernejoul. (2005) LRP5 gene polymorphisms and idiopathic osteoporosis in men. Bone 37:6, 770-775
     

424. 424

     Annalisa Frattini, Paolo Vezzoni, Anna Villa. (2005) The genetics of dominant osteopetrosis. Drug Discovery Today: Disease Mechanisms 2:4, 503-509
     

425. 425

     R. L. van Bezooijen. (2005) Control of Bone Formation by Osteocytes? Lessons from the Rare Skeletal Disorders Sclerosteosis and van Buchem Disease. International Bone and Mineral Society Knowledge Environment 2:12, 33-38
     

426. 426

     Marco G. Cecchini, Antoinette Wetterwald, Gabri van der Pluijm, George N. Thalmann. (2005) Molecular and Biological Mechanisms of Bone Metastasis. EAU Update Series 3:4, 214-226
     

427. 427

     Minrong Ai, Shauna Heeger, Cynthia F. Bartels, Deborah K. Schelling. (2005) Clinical and Molecular Findings in Osteoporosis-Pseudoglioma Syndrome. The American Journal of Human Genetics 77:5, 741-753
     

428. 428

     W. Balemans, L. Wesenbeeck, W. Hul. (2005) A Clinical and Molecular Overview of the Human Osteopetroses. Calcified Tissue International 77:5, 263-274
     

429. 429

     Patricia Crabbe, Wendy Balemans, Andy Willaert, Inge Van Pottelbergh, Erna Cleiren, Paul J Coucke, Minrong Ai, Stefan Goemaere, Wim Van Hul, Anne De Paepe, Jean-Marc Kaufman. (2005) Missense Mutations in LRP5 Are Not a Common Cause of Idiopathic Osteoporosis in Adult Men. Journal of Bone and Mineral Research 20:11, 1951-1959
     

430. 430

     Kim Henriksen, Jeppe Gram, Pernille Høegh-Andersen, Rune Jemtland, Thor Ueland, Morten H. Dziegiel, Sophie Schaller, Jens Bollerslev, Morten A. Karsdal. (2005) Osteoclasts from Patients with Autosomal Dominant Osteopetrosis Type I Caused by a T253I Mutation in Low-Density Lipoprotein Receptor-Related Protein 5 Are Normal in Vitro, but Have Decreased Resorption Capacity in Vivo. The American Journal of Pathology 167:5, 1341-1348
     

431. 431

     Tahir Latif, Mohamad A. Hussein. (2005) Advances in Multiple Myeloma and Spine Disease. Clinical Lymphoma and Myeloma 6:3, 228-233
     

432. 432

     Georges Rawadi, Sergio Roman-Roman. (2005) Wnt signalling pathway: a new target for the treatment of osteoporosis. Expert Opinion on Therapeutic Targets 9:5, 1063-1077
     

433. 433

     Geertje van der Horst, Steffie M van der Werf, Hetty Farih-Sips, Rutger L van Bezooijen, Clemens WGM Löwik, Marcel Karperien. (2005) Downregulation of Wnt Signaling by Increased Expression of Dickkopf-1 and -2 is a Prerequisite for Late-Stage Osteoblast Differentiation of KS483 Cells. Journal of Bone and Mineral Research 20:10, 1867-1877
     

434. 434

     T. J. Martin. (2005) New Aspects of Wnt Signalling Revealed by Mouse and Human Genetics. International Bone and Mineral Society Knowledge Environment 2:10, 7-11
     

435. 435

     Yonghe Li, Guojun Bu. (2005) LRP5/6 in Wnt signaling and tumorigenesis. Future Oncology 1:5, 673-681
     

436. 436

     Zhen-lin ZHANG, Yue-juan QIN, Jin-wei HE, Qi-ren HUANG, Miao LI, Yun-qiu HU, Yu-juan LIU. (2005) Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women1. Acta Pharmacologica Sinica 26:9, 1111-1116
     

437. 437

     Xiaofeng Li, Peng Liu, Wenzhong Liu, Peter Maye, Jianghong Zhang, Yazhou Zhang, Marja Hurley, Caiying Guo, Adele Boskey, Le Sun, Stephen E Harris, David W Rowe, Hua Zhu Ke, Dianqing Wu. (2005) Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nature Genetics 37:9, 945-952
     

438. 438

     Joseph M. Zmuda, Yah-Tyng Sheu, Susan P. Moffett. (2005) Genetic epidemiology of osteoporosis: Past, present, and future. Current Osteoporosis Reports 3:3, 111-115
     

439. 439

     N.H. Kulkarni, D.L. Halladay, R.R. Miles, L.M. Gilbert, C.A. Frolik, R.J.S. Galvin, T.J. Martin, M.T. Gillespie, J.E. Onyia. (2005) Effects of parathyroid hormone on Wnt signaling pathway in bone. Journal of Cellular Biochemistry 95:6, 1178-1190
     

440. 440

     Minghui Qin, Hideyuki Hayashi, Kenji Oshima, Tomoko Tahira, Kenshi Hayashi, Hiroyuki Kondo. (2005) Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. Human Mutation 26:2, 104-112
     

441. 441

     Sohei Kitazawa, Riko Kitazawa, Chiho Obayashi, Tetsuji Yamamoto. (2005) Desmoid Tumor With Ossification in Chest Wall: Possible Involvement of BAMBI Promoter Hypermethylation in Metaplastic Bone Formation. Journal of Bone and Mineral Research 20:8, 1472-1477
     

442. 442

     Yukio Nakamura, Masashi Nawata, Shigeyuki Wakitani. (2005) Expression Profiles and Functional Analyses of Wnt-Related Genes in Human Joint Disorders. The American Journal of Pathology 167:1, 97-105
     

443. 443

     Julie R Hens, Kimberly M Wilson, Pamela Dann, Xuesong Chen, Mark C Horowitz, John J Wysolmerski. (2005) TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro. Journal of Bone and Mineral Research 20:7, 1103-1113
     

444. 444

     Mei Lan Kwee, Wendy Balemans, Erna Cleiren, Johan JP Gille, Frits Van Der Blij, Jan M Sepers, Wim Van Hul. (2005) An Autosomal Dominant High Bone Mass Phenotype in Association With Craniosynostosis in an Extended Family Is Caused by an LRP5 Missense Mutation. Journal of Bone and Mineral Research 20:7, 1254-1260
     

445. 445

     Karen E. Yates, Sonya Shortkroff, Richard G. Reish. (2005) Wnt Influence on Chondrocyte Differentiation and Cartilage Function. DNA and Cell Biology 24:7, 446-457
     

446. 446

     Rutger L. van Bezooijen, Peter ten Dijke, Socrates E. Papapoulos, Clemens W. G.M. Löwik. (2005) SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine & Growth Factor Reviews 16:3, 319-327
     

447. 447

     Xuguang Nie. (2005) Dkk1, -2, and -3 expression in mouse craniofacial development. Journal of Molecular Histology 36:5, 367-372
     

448. 448

     Serge L. Ferrari, R. Rizzoli. (2005) Gene variants for osteoporosis and their pleiotropic effects in aging. Molecular Aspects of Medicine 26:3, 145-167
     

449. 449

     Jian-Su Shao, Su-Li Cheng, Joyce M. Pingsterhaus, Nichole Charlton-Kachigian, Arleen P. Loewy, Dwight A. Towler. (2005) Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. Journal of Clinical Investigation 115:5, 1210-1220
     

450. 450

     Jian-Su Shao, Su-Li Cheng, Joyce M. Pingsterhaus, Nichole Charlton-Kachigian, Arleen P. Loewy, Dwight A. Towler. (2005) Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. Journal of Clinical Investigation 115:5, 1210-1220
     

451. 451

     Michael R Rickels, Xiafang Zhang, Steven Mumm, Michael P Whyte. (2005) Oropharyngeal Skeletal Disease Accompanying High Bone Mass and Novel LRP5 Mutation. Journal of Bone and Mineral Research 20:5, 878-885
     

452. 452

     Régis Levasseur, Didier Lacombe, Marie Christine de Vernejoul. (2005) LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders. Joint Bone Spine 72:3, 207-214
     

453. 453

     Heini Hartikka, Outi Mäkitie, Minna Männikkö, Andrea S Doria, Alan Daneman, William G Cole, Leena Ala-Kokko, Etienne B Sochett. (2005) Heterozygous Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene Are Associated With Primary Osteoporosis in Children. Journal of Bone and Mineral Research 20:5, 783-789
     

454. 454

     B. O. Oyajobi. (2005) Recent Insights into Myeloma Bone Disease. International Bone and Mineral Society Knowledge Environment 2:5, 17-25
     

455. 455

     J. Bollerslev, S.G. Wilson, I.M. Dick, F.M.A. Islam, T. Ueland, L. Palmer, A. Devine, R.L. Prince. (2005) LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women. Bone 36:4, 599-606
     

456. 456

     Kristen M. Borchert, Rachelle J. Sells Galvin, Charles A. Frolik, Laura V. Hale, David L. Halladay, Robin J. Gonyier, O. Joseph Trask, Debra R. Nickischer, Keith A. Houck. (2005) High-Content Screening Assay for Activators of the Wnt/Fzd Pathway in Primary Human Cells. ASSAY and Drug Development Technologies 3:2, 133-141
     

457. 457

     H.H.L. Lau, M.Y.M. Ng, A.Y.Y. Ho, K.D.K. Luk, A.W.C. Kung. (2005) Genetic and environmental determinants of bone mineral density in Chinese women. Bone 36:4, 700-709
     

458. 458

     Amanda Jackson, Béatrice Vayssière, Teresa Garcia, William Newell, Roland Baron, Sergio Roman-Roman, Georges Rawadi. (2005) Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells. Bone 36:4, 585-598
     

459. 459

     Keizo Ohnaka, Mizuho Tanabe, Hisaya Kawate, Hajime Nawata, Ryoichi Takayanagi. (2005) Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochemical and Biophysical Research Communications 329:1, 177-181
     

460. 460

     Serge L Ferrari, Samuel Deutsch, Stylianos E Antonarakis. (2005) Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass. Current Opinion in Lipidology 16:2, 207-214
     

461. 461

     Craig B. Langman. (2005) Genetic regulation of bone mass: from bone density to bone strength. Pediatric Nephrology 20:3, 352-355
     

462. 462

     Joseph P. Stains, Roberto Civitelli. (2005) Cell-to-cell interactions in bone. Biochemical and Biophysical Research Communications 328:3, 721-727
     

463. 463

     Michael P. Whyte. (2005) Misinterpretation of Osteodensitometry With High Bone Density. Journal of Clinical Densitometry 8:1, 1-6
     

464. 464

     M. Audrey Koay, Matthew A. Brown. (2005) Genetic disorders of the LRP5–Wnt signalling pathway affecting the skeleton. Trends in Molecular Medicine 11:3, 129-137
     

465. 465

     Sheri L. Holmen, Scott A. Robertson, Cassandra R. Zylstra, Bart O. Williams. (2005) Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein. Biochemical and Biophysical Research Communications 328:2, 533-539
     

466. 466

     R. T. Moon. (2005) Wnt/ -Catenin Pathway. Science's STKE 2005:271, cm1-cm1
     

467. 467

     Kenneth R. Chien, Gerard Karsenty. (2005) Longevity and Lineages: Toward the Integrative Biology of Degenerative Diseases in Heart, Muscle, and Bone. Cell 120:4, 533-544
     

468. 468

     Gabriel Mbalaviele, Sharmin Sheikh, Joseph P. Stains, Valerie S. Salazar, Su-Li Cheng, Di Chen, Roberto Civitelli. (2005) ?-Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation. Journal of Cellular Biochemistry 94:2, 403-418
     

469. 469

     Ben-Shlomo Izhar. (2005) Sharing of unrelated receptors and ligands by cognate partners: possible implications for ovarian and endometrial physiology. Reproductive BioMedicine Online 11:2, 259-269
     

470. 470

     Christopher J. Logothetis, Sue-Hwa Lin. (2005) Osteoblasts in prostate cancer metastasis to bone. Nature Reviews Cancer 5:1, 21-28
     

471. 471

     Fengcheng Sun, Rita Kohen Avramoglu, Gerard Vassiliou, Robert J. Brown, Kerry W.S. Ko, Ruth McPherson, Zemin Yao. (2005) Do clustered β-propeller domains within the N-terminus of LRP1 play a functional role?. Biochimica et Biophysica Acta (BBA) - General Subjects 1721:1-3, 139-151
     

472. 472

     Daniel L Koller, Shoji Ichikawa, Michelle L Johnson, Dongbing Lai, Xiaoling Xuei, Howard J Edenberg, P Michael Conneally, Siu L Hui, C Conrad Johnston, Munro Peacock, Tatiana Foroud, Michael J Econs. (2005) Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women. Journal of Bone and Mineral Research 20:1, 75
     

473. 473

     Daniel L Koller, Shoji Ichikawa, Michelle L Johnson, Dongbing Lai, Xiaoling Xuei, Howard J Edenberg, P Michael Conneally, Siu L Hui, C Conrad Johnston, Munro Peacock, Tatiana Foroud, Michael J Econs. (2005) Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women. Journal of Bone and Mineral Research 20:1, 75-80
     

474. 474

     Roel NUSSE. (2005) Wnt signaling in disease and in development. Cell Research 15:1, 28-32
     

475. 475

     Lawrence G. Raisz. Bone Biology. In: Bone Disease of Organ Transplantation. Elsevier, 2005:31-45.
     

476. 476

     Tolar , Jakub , Teitelbaum , Steven L. , Orchard , Paul J. , . (2004) Osteopetrosis. New England Journal of Medicine 351:27, 2839-2849
     Full Text

477. 477

     Genevieve M. Boland, Geraldine Perkins, David J. Hall, Rocky S. Tuan. (2004) Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. Journal of Cellular Biochemistry 93:6, 1210-1230
     

478. 478

     Sheri L Holmen, Troy A Giambernardi, Cassandra R Zylstra, Bree D Buckner-Berghuis, James H Resau, J Fred Hess, Vaida Glatt, Mary L Bouxsein, Minrong Ai, Matthew L Warman, Bart O Williams. (2004) Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6. Journal of Bone and Mineral Research 19:12, 2033-2040
     

479. 479

     Régis Levasseur, Jean-Pierre Sabatier, Christian Marcelli. (2004) Physiopathologie de l'ostéoporose. La Revue de Médecine Interne 25, S531-S537
     

480. 480

     Xiaodong Jiao, Valerio Ventruto, Michael T. Trese, Barkur S. Shastry, J.Fielding Hejtmancik. (2004) Autosomal Recessive Familial Exudative Vitreoretinopathy Is Associated with Mutations in LRP5. The American Journal of Human Genetics 75:5, 878-884
     

481. 481

     Catriona Y. Logan, Roel Nusse. (2004) THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE. Annual Review of Cell and Developmental Biology 20:1, 781-810
     

482. 482

     Mark L Johnson, Kimberley Harnish, Roel Nusse, Wim Van Hul. (2004) LRP5 and Wnt Signaling: A Union Made for Bone. Journal of Bone and Mineral Research 19:11, 1749-1757
     

483. 483

     Jennifer J. Westendorf, Rachel A. Kahler, Tania M. Schroeder. (2004) Wnt signaling in osteoblasts and bone diseases. Gene 341, 19-39
     

484. 484

     M Audrey Koay, Peng Y Woon, Yun Zhang, Lisa J Miles, Emma L Duncan, Stuart H Ralston, Juliet E Compston, Cyrus Cooper, Richard Keen, Bente L Langdahl, Alasdair MacLelland, Jeffrey O'Riordan, Huibert A Pols, David M Reid, Andre G Uitterlinden, John AH Wass, Matthew A Brown. (2004) Influence of LRP5 Polymorphisms on Normal Variation in BMD. Journal of Bone and Mineral Research 19:10, 1619-1627
     

485. 485

     Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari, Ajamete Kaykas. (2004) WNT and β-catenin signalling: diseases and therapies. Nature Reviews Genetics 5:9, 691-701
     

486. 486

     Toby Andrew, Alex J. MacGregor. (2004) Genes and osteoporosis. Current Osteoporosis Reports 2:3, 79-89
     

487. 487

     S. Leah Etheridge, Gary J. Spencer, Deborah J. Heath, Paul G. Genever. (2004) Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells. Stem Cells 22:5, 849-860
     

488. 488

     Yoon-Sok Chung, David J Baylink, Apurva K Srivastava, Yousef Amaar, Blanca Tapia, Yuji Kasukawa, Subburaman Mohan. (2004) Effects of Secreted Frizzled-Related Protein 3 on Osteoblasts In Vitro. Journal of Bone and Mineral Research 19:9, 1395-1402
     

489. 489

     Masayo Fujita, Tomohiko Urano, Masataka Shiraki, Mikio Momoeda, Osamu Tsutsumi, Takayuki Hosoi, Hajime Orimo, Yasuyoshi Ouchi, Satoshi Inoue. (2004) Association of a single nucleotide polymorphism in the secreted frizzled-related protein 4 (sFRP4) gene with bone mineral density. Geriatrics and Gerontology International 4:3, 175-180
     

490. 490

     PA Baldock, John A Eisman. (2004) Genetic determinants of bone mass. Current Opinion in Rheumatology 16:4, 450-456
     

491. 491

     M.P. Akhter, D.J. Wells, S.J. Short, D.M. Cullen, M.L. Johnson, G.R. Haynatzki, P. Babij, K.M. Allen, P.J. Yaworsky, F. Bex, R.R. Recker. (2004) Bone biomechanical properties in LRP5 mutant mice. Bone 35:1, 162-169
     

492. 492

     Yonghe Li, Guojun Bu. (2004) LRP5, a multifunctional cell surface receptor. Current Opinion in Lipidology 15:3, 361-363
     

493. 493

     Assia Derfoul, Alyssa L. Carlberg, Rocky S. Tuan, David J. Hall. (2004) Differential regulation of osteogenic marker gene expression by Wnt-3a in embryonic mesenchymal multipotential progenitor cells. Differentiation 72:5, 209-223
     

494. 494

     (2004) High-Bone-Mass Disease and LRP5. New England Journal of Medicine 350:20, 2096-2099
     Free Full Text

495. 495

     Keizo Ohnaka, Hiroshi Taniguchi, Hisaya Kawate, Hajime Nawata, Ryoichi Takayanagi. (2004) Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis. Biochemical and Biophysical Research Communications 318:1, 259-264
     

496. 496

     Serge L. Ferrari, Samuel Deutsch, Urmila Choudhury, Thierry Chevalley, Jean-Philippe Bonjour, Emmanouil T. Dermitzakis, René Rizzoli, Stylianos E. Antonarakis. (2004) Polymorphisms in the Low-Density Lipoprotein Receptor–Related Protein 5 (LRP5) Gene Are Associated with Variation in Vertebral Bone Mass, Vertebral Bone Size, and Stature in Whites. The American Journal of Human Genetics 74:5, 866-875
     

497. 497

     Jan de Boer, Ramakrishnaiah Siddappa, Claudia Gaspar, Aart van Apeldoorn, Ricardo Fodde, Clemens van Blitterswijk. (2004) Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34:5, 818-826
     

498. 498

     Melissa A Kacena, Ramesh A Shivdasani, Kimberly Wilson, Yougen Xi, Nancy Troiano, Ara Nazarian, Caren M Gundberg, Mary L Bouxsein, Joseph A Lorenzo, Mark C Horowitz. (2004) Megakaryocyte-Osteoblast Interaction Revealed in Mice Deficient in Transcription Factors GATA-1 and NF-E2. Journal of Bone and Mineral Research 19:4, 652-660
     

499. 499

     Heinz-Juergen Hausser, Rolf E. Brenner. (2004) Low doses and high doses of heparin have different effects on osteoblast-like Saos-2 cells in vitro. Journal of Cellular Biochemistry 91:5, 1062-1073
     

500. 500

     Carmel Toomes, Helen M. Bottomley, Richard M. Jackson, Katherine V. Towns, Sheila Scott, David A. Mackey, Jamie E. Craig, Li Jiang, Zhenglin Yang, Richard Trembath, Geoffrey Woodruff, Cheryl Y. Gregory-Evans, Kevin Gregory-Evans, Michael J. Parker, Graeme C.M. Black, Louise M. Downey, Kang Zhang, Chris F. Inglehearn. (2004) Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q. The American Journal of Human Genetics 74:4, 721-730
     

501. 501

     Bang H. Hoang, Tadahiko Kubo, John H. Healey, Rebecca Sowers, BethAnne Mazza, Rui Yang, Andrew G. Huvos, Paul A. Meyers, Richard Gorlick. (2004) Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. International Journal of Cancer 109:1, 106-111
     

502. 502

     Shuanhu Zhou, Karim Eid, Julie Glowacki. (2004) Cooperation Between TGF-β and Wnt Pathways During Chondrocyte and Adipocyte Differentiation of Human Marrow Stromal Cells. Journal of Bone and Mineral Research 19:3, 463-470
     

503. 503

     Jan de Boer, Hong Jun Wang, Clemens van Blitterswijk. (2004) Effects of Wnt Signaling on Proliferation and Differentiation of Human Mesenchymal Stem Cells. Tissue Engineering 10:3-4, 393-401
     

504. 504

     Ung-Il CHUNG. (2004) Essential Role of Hypertrophic Chondrocytes in Endochondral Bone Development. Endocrine Journal 51:1, 19-24
     

505. 505

     Jung-Min Koh, Min Hui Jung, Jeong Soo Hong, Hyung Joo Park, Jae Suk Chang, Hyoung Doo Shin, Shin-Yoon Kim, Ghi Su Kim. (2004) Association between Bone Mineral Density and LDL Receptor-Related Protein 5 Gene Polymorphisms in Young Korean Men. Journal of Korean Medical Science 19:3, 407
     

506. 506

     Tian , Erming , Zhan , Fenghuang , Walker , Ronald , Rasmussen , Erik , Ma , Yupo , Barlogie , Bart , Shaughnessy , John D. Jr. , . (2003) The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma. New England Journal of Medicine 349:26, 2483-2494
     Free Full Text

507. 507

     Yingzi Yang. (2003) Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis. Birth Defects Research Part C: Embryo Today: Reviews 69:4, 305-317
     

508. 508

     Olav M. Andersen, Helle H. Petersen. (2003) New Light on a Long-Known Protein Family. ChemBioChem 4:11, 1137-1146
     

509. 509

     Georges Rawadi, Béatrice Vayssière, Fred Dunn, Roland Baron, Sergio Roman-Roman. (2003) BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop. Journal of Bone and Mineral Research 18:10, 1842-1853
     

510. 510

     U KORNAK, S MUNDLOS. (2003) Genetic Disorders of the Skeleton: A Developmental Approach. The American Journal of Human Genetics 73:3, 447-474
     

511. 511

     Benjamin Y. Klein, N. Rojansky, A. Ben-Yehuda, I. Abou-Atta, S. Abedat, G. Friedman. (2003) Cell death in cultured human Saos2 osteoblasts exposed to low-density lipoprotein. Journal of Cellular Biochemistry 90:1, 42-58
     

512. 512

     Sue A Brown, Clifford J Rosen. (2003) Osteoporosis. Medical Clinics of North America 87:5, 1039-1063
     

513. 513

     Lois E. Wehren, Jay Magaziner. (2003) Hip fracture: Risk factors and outcomes. Current Osteoporosis Reports 1:2, 78-85
     

514. 514

     E.J. Mackie. (2003) Osteoblasts: novel roles in orchestration of skeletal architecture. The International Journal of Biochemistry & Cell Biology 35:9, 1301-1305
     

515. 515

     L. Darryl Quarles. (2003) Evidence for a bone-kidney axis regulating phosphate homeostasis. Journal of Clinical Investigation 112:5, 642-646
     

516. 516

     L. Darryl Quarles. (2003) Evidence for a bone-kidney axis regulating phosphate homeostasis. Journal of Clinical Investigation 112:5, 642-646
     

517. 517

     John D. Shaughnessy, Bart Barlogie. (2003) Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling. Immunological Reviews 194:1, 140-163
     

518. 518

     John A Wos, Mark W Lundy. (2003) Patent developments in anabolic agents for treatment of bone diseases. Expert Opinion on Therapeutic Patents 13:8, 1141-1156
     

519. 519

     I. Ben-Shlomo, S. Yu Hsu, R. Rauch, H. W. Kowalski, A. J. W. Hsueh. (2003) Signaling Receptome: A Genomic and Evolutionary Perspective of Plasma Membrane Receptors Involved in Signal Transduction. Science Signaling 2003:187, re9-re9
     

520. 520

     Philip Babij, Weiguang Zhao, Clayton Small, Yogendra Kharode, Paul J Yaworsky, Mary L Bouxsein, Padmalatha S Reddy, Peter Vn Bodine, John A Robinson, Bheem Bhat, James Marzolf, Robert A Moran, Frederick Bex. (2003) High Bone Mass in Mice Expressing a Mutant LRP5 Gene. Journal of Bone and Mineral Research 18:6, 960-974
     

521. 521

     Stavroula Kousteni, Li Han, Jin-Ran Chen, Maria Almeida, Lilian I. Plotkin, Teresita Bellido, Stavros C. Manolagas. (2003) Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. Journal of Clinical Investigation 111:11, 1651-1664
     

522. 522

     Stavroula Kousteni, Li Han, Jin-Ran Chen, Maria Almeida, Lilian I. Plotkin, Teresita Bellido, Stavros C. Manolagas. (2003) Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. Journal of Clinical Investigation 111:11, 1651-1664
     

523. 523

     Shun-ichi Harada, Gideon A. Rodan. (2003) Control of osteoblast function and regulation of bone mass. Nature 423:6937, 349-355
     

524. 524

     John D. Shaughnessy. (2003) Global Gene Expression Profiling in the Study of Multiple Myeloma. International Journal of Hematology 77:3, 213-225
     

525. 525

     Louis C. Gerstenfeld, Dennis M. Cullinane, George L. Barnes, Dana T. Graves, Thomas A. Einhorn. (2003) Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation. Journal of Cellular Biochemistry 88:5, 873-884
     

526. 526

     Liesbeth Van Wesenbeeck, Erna Cleiren, Jeppe Gram, Rodney K. Beals, Olivier Bénichou, Domenico Scopelliti, Lyndon Key, Tara Renton, Cindy Bartels, Yaoqin Gong, Matthew L. Warman, Marie-Christine de Vernejoul, Jens Bollerslev, Wim Van Hul. (2003) Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density. The American Journal of Human Genetics 72:3, 763-771
     

527. 527

     Omar M.E Albagha, Stuart H Ralston. (2003) Genetic determinants of susceptibility to osteoporosis. Endocrinology and Metabolism Clinics of North America 32:1, 65-81
     

528. 528

     Unnur Styrkarsdottir, Jean-Baptiste Cazier, Augustine Kong, Ottar Rolfsson, Helene Larsen, Emma Bjarnadottir, Vala D. Johannsdottir, Margret S. Sigurdardottir, Yu Bagger, Claus Christiansen, Inga Reynisdottir, Struan F. A. Grant, Kristjan Jonasson, Michael L. Frigge, Jeffrey R. Gulcher, Gunnar Sigurdsson, Kari Stefansson. (2003) Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2. PLoS Biology 1:3, e9
     

529. 529

     Nicholas Harvey, Cyrus Cooper. (2003) Determinants of fracture risk in osteoporosis. Current Rheumatology Reports 5:1, 75-81
     

530. 530

     Jane E. Aubin, Johan N.M. Heersche. Bone Cell Biology Osteoblasts, Osteocytes, and Osteoclasts. In: Pediatric Bone. Elsevier, 2003:43-75.
     

531. 531

     Nuria Guañabens. (2003) Osteoporosis 2003. Medicina Clínica 121:16, 625-630
     

532. 532

     Linda J. Sandell, Dwight A. Towler. (2002) Transcription of bone and cartilage genes. Current Opinion in Orthopaedics 13:5, 375-381
     

533. 533

     (2002) High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5. New England Journal of Medicine 347:12, 943-944
     Free Full Text

534. 534

     Krane , Stephen M. , . (2002) Genetic Control of Bone Remodeling — Insights from a Rare Disease. New England Journal of Medicine 347:3, 210-212
     Full Text

535. 535

     Patel , Millan S. , Karsenty , Gerard , . (2002) Regulation of Bone Formation and Vision by LRP5. New England Journal of Medicine 346:20, 1572-1574
     Full Text

536. 536

     E. Seeman. (2001) Clinical Papers: November 2002 Selections. International Bone and Mineral Society Knowledge Environment 1:1, 2003079-0
     

537. 537

     G. A. Rodan. (2001) Meeting Report from the IOF World Congress on Osteoporosis. International Bone and Mineral Society Knowledge Environment 1:1, 2002051-0
     

Letters