Original Article
A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization
N Engl J Med 2002; 346:1773-1780June 6, 2002
- Abstract
Background
The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris.
Methods
We performed a randomized, double-blind trial to compare the two types of stents for revascularization of single, primary lesions in native coronary arteries. The trial included 238 patients at 19 medical centers. The primary end point was in-stent late luminal loss (the difference between the minimal luminal diameter immediately after the procedure and the diameter at six months). Secondary end points included the percentage of in-stent stenosis of the luminal diameter and the rate of restenosis (luminal narrowing of 50 percent or more). We also analyzed a composite clinical end point consisting of death, myocardial infarction, and percutaneous or surgical revascularization at 1, 6, and 12 months.
Results
At six months, the degree of neointimal proliferation, manifested as the mean (±SD) late luminal loss, was significantly lower in the sirolimus-stent group (–0.01±0.33 mm) than in the standard-stent group (0.80±0.53 mm, P<0.001). None of the patients in the sirolimus-stent group, as compared with 26.6 percent of those in the standard-stent group, had restenosis of 50 percent or more of the luminal diameter (P<0.001). There were no episodes of stent thrombosis. During a follow-up period of up to one year, the overall rate of major cardiac events was 5.8 percent in the sirolimus-stent group and 28.8 percent in the standard-stent group (P<0.001). The difference was due entirely to a higher rate of revascularization of the target vessel in the standard-stent group.
Conclusions
As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events.
Media in This Article
Figure 1
Cumulative Frequency of Stenosis Immediately after Stenting and at Six Months in Patients Who Received Sirolimus-Eluting Stents and in Those Who Received Standard Stents.Figure 2
Kaplan–Meier Estimates of Survival Free of Myocardial Infarction and Repeated Revascularization among Patients Who Received Sirolimus-Eluting Stents and Those Who Received Standard Stents.Article Activity
- Article
The growing use of stents has improved the results of percutaneous coronary revascularization.1-5 However, in-stent restenosis continues to limit the long-term success of this approach.6,7 For example, in a recent randomized comparison of coronary-artery bypass surgery and stenting in patients with multivessel disease, additional revascularization procedures were performed within one year in 21.0 percent of patients who had undergone stenting, as compared with 3.8 percent of patients treated surgically.8
In controlled trials, several pharmaceutical agents have failed to inhibit restenosis after coronary interventions.9 In contrast, the systemic and local delivery of sirolimus (rapamycin), a macrocyclic lactone that inhibits cytokine-mediated and growth-factor–mediated proliferation of lymphocytes and smooth-muscle cells, reduced neointimal proliferation in studies in animals and in a small clinical study.10-12 We conducted a study to compare the performance of a coronary stent that slowly releases sirolimus over a period of 30 days with that of a standard uncoated stent.
Methods
Selection of Patients
The study was a randomized, double-blind trial performed at 19 medical centers (listed in the Appendix). It was approved by the ethics committee at each participating institution, and all patients gave written informed consent. The study was conducted from August 2000 to August 2001.
Patients were eligible for the study if they were 18 to 85 years old, were not pregnant and were protected against pregnancy during the study, and had received a diagnosis of stable or unstable angina or silent ischemia. Additional eligibility criteria were the presence of a single primary target lesion in a native coronary artery that was 2.5 to 3.5 mm in diameter and that could be covered by an 18-mm stent; stenosis of 51 to 99 percent of the luminal diameter, as estimated visually; and a flow rate of grade 1 or higher according to the classification of the Thrombolysis in Myocardial Infarction (TIMI) trial. Patients were not eligible for enrollment if they had an evolving myocardial infarction, stenosis of the left-main coronary artery, unprotected by a graft, that caused luminal narrowing of 50 percent or more, an ostial lesion, a calcified lesion that could not be completely dilated before stenting, an angiographically visible thrombus within the target lesion, a left ventricular ejection fraction of less than 30 percent, or an intolerance of aspirin, clopidogrel, ticlopidine, heparin, stainless steel, or contrast material.
The Sirolimus-Eluting Stent
Sirolimus was blended in a mixture of nonerodable polymers, and a layer of sirolimus–polymer matrix with a thickness of 5 μm was applied to the surface of a stainless-steel, balloon-expandable stent (Bx Velocity, Cordis, Johnson & Johnson). The stent was loaded with a fixed amount of sirolimus per unit of metal surface area (140 μg of sirolimus per square centimeter). A layer of drug-free polymer was applied on top of the drug–polymer matrix as a diffusion barrier to prolong the release of the drug. The stent was designed to release approximately 80 percent of the drug within 30 days after implantation.
Study Procedures
Codes for random assignments to the treatment groups were generated by computer in blocks of four and were distributed in sealed envelopes to each participating center. Patients were randomly assigned to the groups in a 1:1 ratio.
Lesions were treated with the use of standard interventional techniques. Stenting without predilation was prohibited. After successful predilation, patients were randomly assigned in a double-blind fashion to receive a standard uncoated stent or a sirolimus-eluting stent mounted on a rapid-exchange delivery system and inflated to 10 to 16 atm. The sirolimus-eluting stents were indistinguishable, except under a microscope, from the uncoated stents. After the stent had been implanted, further dilation was performed as necessary to ensure that there was less than 20 percent residual stenosis, with a TIMI grade III flow rate. In case of dissection or incomplete coverage of the lesion, additional stents of the same type as the assigned stent (coated or uncoated) were used.
Intravenous boluses of heparin were administered to maintain an activated clotting time that exceeded 250 seconds during the procedure and were discontinued within 12 hours. Treatment with aspirin, at a dose of at least 100 mg per day, was begun 12 hours before the procedure and continued indefinitely. A loading dose of 300 mg of clopidogrel was administered 48 hours before the procedure, followed by 75 mg daily for eight weeks. Alternatively, treatment with ticlopidine, at a dose of 250 mg twice daily, was begun one day before the procedure and continued for eight weeks. A successful procedure was defined as the successful implantation of the study device, with stenosis of less than 20 percent of the vessel diameter and no major cardiac events during the hospital stay.
Follow-up
Patients were evaluated at 30 days and at 6 and 12 months. They were asked specific questions about the interim development of angina, according to the Canadian Cardiovascular Society classification of stable angina13 and the Braunwald classification of unstable angina.14 The patients were also monitored for major cardiac events and for the need for additional revascularization of the index target lesion. An electrocardiogram was obtained at each visit, and an angiographic study was performed at a mean (±SD) of 180±30 days. Other studies and tests were performed at the discretion of the investigators at the participating centers. Because of the double-blind nature of the study, the decision to perform further revascularization of the target lesion or vessel after the six-month angiographic study was also left to the investigators' discretion.
Quantitative Coronary Angiographic Evaluation
Coronary angiograms were obtained in multiple views after the intracoronary injection of nitrates. Quantitative analyses of all angiographic data before, during, and after the procedure were performed by an independent core laboratory (Cardialysis, Rotterdam, the Netherlands) with the use of edge-detection techniques. The luminal diameter of the coronary artery and the degree of stenosis were measured before dilation, at the end of the procedure, and at six months. Restenosis was defined as stenosis of 50 percent or more of the luminal diameter. Late luminal loss was defined as the difference between the minimal luminal diameter immediately after the procedure and the diameter at six months. The target lesion was defined as the stented segment plus the 5-mm segments proximal and distal to the stented segment.
Intravascular Ultrasound Substudy
At the six-month visit, intravascular ultrasound examinations were performed by six centers in subgroups of 48 patients who had received a sirolimus-eluting stent and 47 who had received an uncoated stent.
Study End Points
The primary angiographic end point was in-stent luminal late loss, as determined by quantitative angiography. Secondary end points included the percentage of in-stent stenosis of the luminal diameter, the rate of restenosis (luminal narrowing of 50 percent or more), and the minimal luminal diameter of the stented segment and of the 5-mm segments proximal and distal to the stent at six months.
The primary clinical end point of the study was a composite of major cardiac events, including death, Q-wave or non–Q-wave myocardial infarction, coronary-artery bypass grafting, and revascularization of the target lesion or vessel 30 days, 6 months, and 12 months after the index procedure. A non–Q-wave myocardial infarction was defined by an increase in the creatine kinase level to more than twice the upper limit of the normal range, accompanied by an increased level of creatine kinase MB, in the absence of new Q waves on the surface electrocardiogram.
The end points were adjudicated by an independent clinical-events committee. In addition, a data and safety monitoring board that was not affiliated with the study sponsor reviewed the data to identify any safety issues related to the conduct of the study.
Statistical Analysis
We calculated that with a sample of 207 patients, the study would have 90 percent power to detect a difference in the mean late luminal loss of 0.25 mm between the two groups, assuming a standard deviation of 0.55 mm in each group, with the use of a two-group t-test and a two-sided significance level of 0.05.
All analyses were based on the intention-to-treat principle. For continuous variables, differences between the treatment groups were evaluated by analysis of variance or Wilcoxon's rank-sum test. For discrete variables, differences were expressed as counts and percentages and were analyzed with Fisher's exact test.
Revascularization of the target lesion or vessel and the composite of major adverse events during follow-up were analyzed by the Kaplan–Meier method. Differences between the event-free survival curves for the two groups were compared with the use of the Wilcoxon and log-rank tests.
All listed authors participated in the study design, enrollment of patients, and data interpretation. The data were held by the core laboratory (Cardialysis, Rotterdam, the Netherlands), but all investigators had full access to them.
Results
Characteristics of the Patients
Between August 2000 and January 2001, 120 patients were randomly assigned to receive the sirolimus-eluting stent, and 118 were assigned to receive the standard stent. With the exception of a significantly higher percentage of men in the standard-stent group, the two groups were similar with respect to all variables examined (Table 1Table 1
Base-Line Characteristics of the Overall Patient Population and of Each Treatment Group.). Overall, 76 percent of the patients were men, and the mean age was 60.7 years, with the expected prevalences of dyslipidemia, diabetes, hypertension, and current tobacco use. Stenting was performed because of unstable angina in 50 percent of the patients. The target vessel was the left anterior descending coronary artery in 50 percent of the patients, the right coronary vessel in 27 percent, and the left circumflex artery in 23 percent. Nearly all the treated lesions were class B1 or B2 according to the American College of Cardiology–American Heart Association classification. Although all the target index lesions were primary lesions, 1.7 percent of the patients had undergone previous coronary-artery surgery and 18.1 percent had undergone previous percutaneous interventions for the treatment of other lesions.Procedural Characteristics
The lesions in the two groups were treated similarly with the use of conventional techniques. Platelet glycoprotein IIb/IIIa inhibitors, the use of which was left to the discretion of the investigators at the participating centers, were administered to 10.1 percent of the patients in the sirolimus-stent group and 9.5 percent of those in the standard-stent group. The two groups did not differ significantly with respect to the rate of successful stent placement (96.6 percent in the sirolimus-stent group and 93.1 percent in the standard-stent group).
Quantitative Angiographic Analysis
Angiographic data at six months were available for 211 of the 238 patients (88.7 percent). The mean reference diameter of the target vessel and the mean length of the lesion at base line were similar in the two groups (Table 1). The mean minimal luminal diameter of the stented segment and the length of the lesion before and after the procedure, as well as the reduction in stenosis immediately after the procedure, were also similar in the two groups (Table 2Table 2
Results of Subsegmental Quantitative Angiographic Analysis.). At six months, however, the mean minimal luminal diameter of the stented segment was significantly greater in the sirolimus-stent group. The mean in-stent late loss, percentage of stenosis, and percentage of patients with 50 percent or more stenosis were –0.01 mm, 14.7 percent, and 0 percent, respectively, in the sirolimus-stent group, as compared with 0.80 mm, 36.7 percent, and 26.6 percent, respectively, in the standard-stent group (P<0.001 for each comparison). Figure 1Figure 1Cumulative Frequency of Stenosis Immediately after Stenting and at Six Months in Patients Who Received Sirolimus-Eluting Stents and in Those Who Received Standard Stents. shows the cumulative frequency of stenosis immediately after the index procedure and at six months in each treatment group. Table 2 shows the results of subsegmental quantitative angiographic analyses. The late luminal loss at both the proximal and the distal edges of the stent was significantly less in the sirolimus-stent group than in the standard-stent group (P<0.001 for both comparisons). There was a small degree of restenosis at the edges of the standard stent that was not present with the sirolimus-eluting stent.In the subgroup of patients with diabetes, 19 patients received sirolimus-eluting stents, and 25 received standard stents. The minimal luminal diameter before and after stenting was similar in the two groups (0.99 mm in the sirolimus-stent group and 0.93 mm in the standard-stent group before the procedure and 2.37 and 2.36 mm, respectively, afterward). However, at six months, the minimal luminal diameter was markedly larger in the sirolimus-stent group (2.29 mm, vs. 1.56 mm in the standard-stent group; P<0.001); consequently, the late loss was smaller (0.07 mm in the sirolimus-stent group vs. 0.82 mm in the standard-stent group, P<0.001) and the restenosis rate was lower (0 percent vs. 41.7 percent, P=0.002).
Intravascular Ultrasound Evaluation
At six months, intravascular ultrasound examination showed no significant differences between the two groups with respect to the volume of the stent, the volume of the overall vessel, or the volume of the plaque behind the stent. However, the sirolimus-stent group had significantly less neointimal hyperplasia than did the standard-stent group (2±5 vs. 37±28 mm3) and significantly less volume obstruction, defined as the ratio of the volume of hyperplasia to the volume of the stent, multiplied by 100 (1±3 percent vs. 29±20 percent) (P<0.001 for both comparisons). These findings are consistent with the nearly complete suppression of in-stent neointimal hyperplasia by sirolimus. In addition, there was no evidence of an “edge effect,” aneurysm formation, in-stent thrombosis, or persistent dissection.
Adverse Events
Major cardiac events are listed in Table 3Table 3
Cardiac Events in the Hospital and during One Year of Follow-up.. Three patients in each group had a myocardial infarction at the time of stenting. In the sirolimus-stent group, two of the patients with myocardial infarction underwent angiography in the hospital, which showed a patent stent in each. The third patient had a non–Q-wave myocardial infarction, and the angiographic study performed at six months showed a patent stent. One recipient of a standard stent underwent further percutaneous revascularization of the target vessel for the treatment of a lesion other than the index lesion.During a follow-up period of up to one year, two patients in the standard-stent group (1.7 percent) died: one had a myocardial infarction and died suddenly several weeks later, and the other had a gastric hemorrhage. Two patients in the sirolimus-stent group (1.7 percent) also died: one had a subarachnoid hemorrhage, and the other had gastrointestinal cancer. One patient in each group underwent surgical revascularization of the index target vessel.
Percutaneous revascularization of the target lesion was performed in 27 recipients of standard stents (22.9 percent) but in none of the recipients of sirolimus-eluting stents (P=0.001). Subacute or late thrombotic occlusion of the stent did not occur in either group.
Kaplan–Meier estimates of event-free survival are shown in Figure 2Figure 2
Kaplan–Meier Estimates of Survival Free of Myocardial Infarction and Repeated Revascularization among Patients Who Received Sirolimus-Eluting Stents and Those Who Received Standard Stents.. The overall rate of major cardiac events was 5.8 percent in the sirolimus-stent group and 28.8 percent in the standard-stent group (P<0.001). The difference between the two groups was entirely due to the greater need for repeated revascularization of the target vessel in the standard-stent group. No adverse effects were attributable to the sirolimus coating of stents.Discussion
We found that use of a sirolimus-eluting stent resulted in the virtual elimination of in-stent neointimal hyperplasia; thus, there was no angiographic evidence of restenosis and no need for repeated interventions. Since the introduction of angioplasty, restenosis has been a major factor limiting the long-term success of percutaneous coronary revascularization.15 The refinement of stenting techniques in the past decade has substantially improved the overall results of the procedure.3,4,16,17 Despite considerable efforts to prevent the development of restenosis, however, including systemic or local delivery of biochemical substances and drugs9 and the use of various devices,18-22 additional target-vessel revascularization is required in more than 15 percent of patients.8,23 Although catheter-based brachytherapy is effective in the treatment of in-stent restenosis,24 its value in the treatment of primary lesions is less clear. Furthermore, the use of brachytherapy is limited by its high cost and burdensome instrumentation and by the risks inherent in the use of radioisotopes.
In this context, the benefit of the sirolimus-eluting stent in our study was particularly striking. This new device appears to have virtually eliminated the development of neointimal proliferation. Yet its use did not require special implantation techniques or instrumentation and was innocuous within the time frame of the study.
In the group of patients with sirolimus-eluting stents, the percentage of stenosis at six months was essentially the same as that immediately after the procedure and was in all cases less than 35 percent. The virtual absence of late loss in the luminal diameter in this group is consistent with the arrest of in-stent neointimal proliferation by sirolimus. Also noteworthy was the absence of restenosis and major cardiac events in the patients with diabetes who received sirolimus-eluting stents. Whether these effects can be sustained for several years remains to be determined. The results thus far suggest that the use of an appropriate therapeutic agent when growth-factor–induced cell proliferation is at its peak can have substantial effects on the process of in-stent restenosis.
Sirolimus, a macrolide antifungal agent with a unique antiproliferative mode of action and powerful immunosuppressant properties, inhibits several regulators of cell-cycle progression and the migration of vascular smooth-muscle cells.25 Yet studies in animals have shown that reendothelialization may occur even while sirolimus is being eluted.26 Moreover, recent experiments in animals have shown that sirolimus blocks inflammation.26 These antiproliferative, antimigratory, and antiinflammatory properties are responsible for the efficacy of sirolimus therapy in preventing acute rejection of renal allografts and arteriopathy of cardiac allografts, as well as in-stent restenosis. The wide safety margin of sirolimus27 and the minuscule amounts of drug released into the blood explain the absence of detectable adverse effects in our trial and in a previous clinical study.12
The restenosis rate of 27 percent in the standard-stent group may seem high. However, on the basis of a linear regression model derived from the Stent Restenosis Study and the Benestent I and II studies (unpublished data), the predicted rate of restenosis for our patient cohort was approximately 28 percent. Of the 27 patients in the standard-stent group who underwent revascularization of the target vessel (22.9 percent), 16 did so because of angina or abnormal stress tests and 11 because of angiographic evidence of restenosis.
Despite the absence of late luminal loss in the sirolimus-stent group, reendothelialization presumably occurred, since none of the patients in the group had acute, subacute, or late thrombosis, even though they received combined antiplatelet therapy for only two months. These findings are similar to reported observations in animals.26
We enrolled patients with single lesions that were up to 18 mm long. Whether the positive results in these patients can be expected in patients with more complex or more extensive disease remains to be determined. However, a subgroup analysis showed that the results in patients with diabetes were similar to those in patients without diabetes.
In this trial, 2.5-mm stents were used in 18 percent of the patients randomly assigned to the sirolimus-stent group. Furthermore, division of the treatment groups into thirds according to the vessel diameter revealed virtually identical late luminal loss, even in the smallest arteries.
Stents that deliver drugs are complex devices with three components: the stent, the drug, and the coating. The long-term outcome of treatment with these devices will depend on the response to all three components.
In conclusion, patients with angina who received sirolimus-eluting stents for the treatment of single, primary lesions in native coronary arteries had no angiographic evidence of late luminal loss or in-stent restenosis at six months, no episodes of thrombosis, and a very low rate of cardiac events at one year.
Supported by a grant from Cordis, a Johnson & Johnson company.
Dr. Falotico is an employee of Cordis.
We are indebted to Drs. Rodolphe Ruffy, Brian Firth, and Dennis Donohoe for their assistance in drafting and reviewing the manuscript.
Source Information
From Institut Cardiovasculaire Paris Sud, Massy, France (M.-C.M.); Thoraxcentrum, Rotterdam, the Netherlands (P.W.S.); Institute Dante Pazzanese de Cardiologia, São Paulo, Brazil (J.E.S.); Clinique Pasteur, Toulouse, France (J.F.); Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico (E.B.H.); the Heart Institute of the University of São Paulo, São Paulo, Brazil (M.P.); Centro Cuore Columbus, Milan, Italy (A.C.); Herzzentrum, Leipzig, Germany (G.S.); Centre Hospitalier Privé Beauregard, Marseilles, France (P.B.); Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Semmelweis Egyetem Egészégtudomanyi Kar, Budapest, Hungary (F.M.); and Cordis, Johnson & Johnson, Warren, N.J. (R.F.).
Address reprint requests to Dr. Morice at the Institut Hospitalier Jacques Cartier, Ave. du Noyer Lambert, 91300 Massy, France.
The members of the RAVEL (Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patients with de Novo Native Coronary Artery Lesions) study group are listed in the Appendix.
Appendix
The following investigators and institutions participated in the RAVEL study: Steering Committee — M.C. Morice (chairperson), Massy, France; P.W. Serruys (cochairperson), Rotterdam, the Netherlands; K. Nijssen, Rotterdam, the Netherlands; C. Bode, Freiburg, Germany; P. Barragan, Marseilles, France; and M. Delattre, Waterloo, Belgium; Sponsor — Cordis, Johnson & Johnson, Warren, N.J., E. Wülfert (program coordinator) and C. Demeyere, Waterloo, Belgium; Data and Safety Monitoring Board — J.G.P. Tijssen, Amsterdam; G. Steg, Paris; and P. Vranckx, Rotterdam, the Netherlands; Data Management — Cardialysis, Rotterdam, the Netherlands; Clinical Events Committee — J. Deckers (chairperson), Rotterdam, the Netherlands; J.A.M. te Riele, Breda, the Netherlands; and L.G.P.M. van Zeijl, Rotterdam, the Netherlands; Core Angiographic Laboratory — C. Disco, K. Nijssen, and A. Spierings, Cardialysis, Rotterdam, the Netherlands; Clinical sites — M.C. Morice, T. Lefèvre, and Y. Louvard, Institut Cardiovasculaire Paris Sud, Massy, France; P.W. Serruys, M. van den Brand, D. Foley, W. van der Giessen, P. de Feyter, P. Smits, and J. Vos, Thoraxcentrum, Rotterdam, the Netherlands; C. Bode, M. Rave, and C. Holubarsch, Albert Ludwigs Universitätskliniken, Freiburg, Germany; P. Barragan, J.B. Simeoni, C.O. Roquebert, and P. Commeau, Clinique Beauregard, Marseilles, France; G. Schuler, P. Sick, and M. Woinke, Herzzentrum, Leipzig, Germany; G.J. Laarman and F. Kiemeney, Onze Lieve Vrouwe Gasthuis, Amsterdam; W. Wijns, B. de Bruyne, J. Bartunek, P. de Bruyne, G.R. Heyndrickx, Onze Lieve Vrouwe Kliniek, Aalst, Belgium; J. Fajadet, J. Marco, B. Farah, P. Sousa, and M. Boccalatte, Clinique Pasteur, Toulouse, France; J.L. Guermonprez, Hôpital Européen Georges Pompidou, Paris; A. Colombo, C. di Mario, R. Albiero, and N. Corvaja, Centro Cuore Columbus, Milan, Italy; A. Bartorelli, S. Galli, F. Fabbiochi, P. Motorsi, D. Trabattoni, and A. Loaldi, Centro Cardiologico Monzino, Milan, Italy; G. Guagliumi, O. Valsecchi, M. Tespili, A. Vassileva, and A. Saimo, Ospedali Riuniti di Bergamo, Bergamo, Italy; F. Molnàr, R.G. Kiss, L. Major, and G. Bokori, Semmelweis Egyetem Egészégtudomanyi Kar, Budapest, Hungary; E. Ban Hayashi, I. Sanchez, J. Gaspar, R. Villavicencio, and M.A. Pena Duque, Instituto Nacional de Cardiologia, Mexico City, Mexico; J.E. Sousa, E. Sousa, A.S. Abizaid, A. Abizaid, A. Sousa, F. Feres, L.A. Mattos, M. Costa, and R. Staico, Institute Dante Pazzanese de Cardiologia, São Paulo, Brazil; M. Perin, E. Ribeiro, E. Martinez, P. Soares, and F. Demartino, University Hospital of São Paulo, São Paulo, Brazil; D. Blanchard and O. Bar, Clinique Saint-Gatien, Tours, France; A. Cribier, H. Eltchaninoff, Centre Hospitalier Universitaire de Rouen, Rouen, France.
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- Citing Articles (1298)
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S.N. Willich, F. Müller-Riemenschneider, D. McBride, S. Silber, K.-H. Kuck, C.A. Nienaber, S. Schneider, J. Senges, B. Brüggenjürgen. (2012) Health economic evaluation of the use of drug-eluting stents. Herz
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F. Karaahmet, S. Kılıncalp, A. Altınbas, S. Coban, O. Yuksel. (2012) Intrabiliary rapamycin may slow progression of primary sclerosing cholangitis. Alimentary Pharmacology & Therapeutics 35:4, 490-491
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Jennifer K. Chen, Pedram Ghasri, Guillermo Aguilar, Anne Margreet van Drooge, Albert Wolkerstorfer, Kristen M. Kelly, Michal Heger. (2012) An overview of clinical and experimental treatment modalities for port wine stains. Journal of the American Academy of Dermatology
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Vivian G. Ng, Alexandra J. Lansky. (2012) The Generations of Drug-Eluting Stents and Outcomes in Women. Interventional Cardiology Clinics
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Run Du, Rui Yan Zhang, Qi Zhang, Yu Hang Shi, Jian Hu, Zhen Kun Yang, Feng Hua Ding, Jian Sheng Zhang, Wei Feng Shen. (2012) Assessment of the relation between IVUS measurements and clinical outcome in elderly patients after sirolimus-eluting stent implantation for de novo coronary lesions. The International Journal of Cardiovascular Imaging
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Jerome J. Federspiel, Sally C. Stearns, Kristin L. Reiter, Kimberley H. Geissler, Matthew A. Triplette, Laura P. D'Arcy, Brett C. Sheridan, Joseph S. Rossi. (2012) Disappearing and reappearing differences in drug-eluting stent use by race. Journal of Evaluation in Clinical Practiceno-no
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Ryota Sakurai, Tsukasa Inajima, Hideaki Kaneda, Ryozo Nagai, Hideki Hashimoto. (2012) Sirolimus-eluting stents reduce long-term mortality compared with bare metal stents in ST-segment elevation myocardial infarction: A meta-analysis of randomized controlled trials. International Journal of Cardiology
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Corrado Tamburino, Davide Capodanno, Maria Elena Di Salvo, Alessandra Sanfilippo, Irene Cascone, Valentina Incardona, Giovanni Longo, Daniele Giacoppo, Piera Capranzano, Carmelo Sgroi, Gianpaolo Ussia, Alfio Monaco, Alessio La Manna. (2012) Safety and effectiveness of the Catania Polyzene-F coated stent in real world clinical practice: 12-month results from the ATLANTA 2 registry. EuroIntervention 7:9, 1062-1068
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Michael Joner, Qi Cheng, Sabine Schönhofer-Merl, Monica Lopez, Stefanie Neubauer, Carlos Mas-Moruno, Burkhardt Laufer, Frank D. Kolodgie, Horst Kessler, Renu Virmani. (2012) Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces. Journal of Biomedical Materials Research Part B: Applied Biomaterialsn/a-n/a
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Syed Ahmed, Prabir Roy-Chaudhury. (2012) Radiation Therapy for Dialysis Access Stenosis: Unfulfilled Promise or False Expectations. Seminars in Dialysisno-no
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Theodore Parker, Vipul Davé, Robert Falotico, Jonathon Zhao, Thai Nguyen, Sylvia He, Yi-Ping Sun, Campbell Rogers. (2012) Control of cilostazol release kinetics and direction from a stent using a reservoir-based design. Journal of Biomedical Materials Research Part B: Applied Biomaterialsn/a-n/a
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Ami Raval, Arpan Parmar, Ankur Raval, Pratap Bahadur. (2012) Preparation and optimization of media using Pluronic® micelles for solubilization of sirolimus and release from the drug eluting stents. Colloids and Surfaces B: Biointerfaces
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Stuart J Head, Ad JJC Bogers, A Pieter Kappetein. (2012) Drug-eluting stent implantation for coronary artery disease: current stents and a comparison with bypass surgery. Current Opinion in Pharmacology
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Yoshitaka Muraoka, Shinjo Sonoda, Kuninobu Kashiyama, Fumihiko Kamezaki, Yuki Tsuda, Masaru Araki, Masahiro Okazaki, Yutaka Otsuji. (2011) Evaluation of in-stent neointimal tissue components using integrated backscatter intravascular ultrasound: comparison of drug-eluting stents and bare-metal stents. The International Journal of Cardiovascular Imaging
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Masato Nakamura, Yoritaka Otsuka, Yasunori Ueda, Kazuaki Mitsudo. (2011) Favorable pharmacokinetics of biolimus A9 after deployment of Nobori stent for coronary artery disease: insights from Nobori PK study in Japanese subjects. Cardiovascular Intervention and Therapeutics
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M. L. Sampietro, S. Trompet, J. J. W. Verschuren, R. P. Talens, J. Deelen, B. T. Heijmans, R. J. de Winter, R. A. Tio, P. A. F. M. Doevendans, S. K. Ganesh, E. G. Nabel, H.-J. Westra, L. Franke, E. B. van den Akker, R. G. J. Westendorp, A. H. Zwinderman, A. Kastrati, W. Koch, P. E. Slagboom, P. de Knijff, J. W. Jukema. (2011) A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. Human Molecular Genetics 20:23, 4748-4757
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Sandy M. Green, Faith Selzer, Suresh R. Mulukutla, Edward J. Tadajweski, Jamie A. Green, Robert L. Wilensky, Warren K. Laskey, Howard A. Cohen, Sunil V. Rao, Steven D. Weisbord, Joon S. Lee, Steven E. Reis, Kevin E. Kip, Sheryl F. Kelsey, David O. Williams, Oscar C. Marroquin. (2011) Comparison of Bare-Metal and Drug-Eluting Stents in Patients with Chronic Kidney Disease (from the NHLBI Dynamic Registry). The American Journal of Cardiology 108:11, 1658-1664
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I. S. Toor, R. Jaumdally, G. Y. H. Lip, D. Pagano, W. Dimitri, T. Millane, C. Varma. (2011) Differences between South Asians and White Europeans in five year outcome following percutaneous coronary intervention. International Journal of Clinical Practice 65:12, 1259-1266
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Saeed Ansari, Douglas J. McConnell, Gregory J. Velat, Michael F. Waters, Elad I. Levy, Brian L. Hoh, J. Mocco. (2011) Intracranial Stents for Treatment of Acute Ischemic Stroke: Evolution and Current Status. World Neurosurgery 76:6, S24-S34
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Randall C. Edgell, Osama O. Zaidat, Rishi Gupta, Alex Abou-Chebl, Italo Linfante, Andrew Xavier, Raul Nogueira, Amer Alshekhlee, Jundaid Kalia, Vahid Etezadi, Nima Aghaebrahim, Tudor Jovin. (2011) Multicenter Study of Safety in Stenting for Symptomatic Vertebral Artery Origin Stenosis: Results from the Society of Vascular and Interventional Neurology Research Consortium. Journal of Neuroimagingno-no
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, B. Scheller, B. Levenson, M. Joner, R. Zahn, V. Klauss, C. Naber, V. Schächinger, A. Elsässer. (2011) Medikamente freisetzende Koronarstents und mit Medikamenten beschichtete Ballonkatheter. Der Kardiologe
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Andres Kotsar, Riina Nieminen, Taina Isotalo, Joonas Mikkonen, Ilkka Uurto, Minna Kellomäki, Martti Talja, Eeva Moilanen, Teuvo L.J. Tammela. (2011) Preclinical evaluation of new indomethacin-eluting biodegradable urethral stent. Journal of Endourology111103124138007
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Muhammed Akhtar, Alain Waked, Hilal Bhat, Mariam Khalid, Sumaya Teli, Faisal B Saiful, James Lafferty, Tariq Bhat. (2011) Drug-eluting stent thrombosis after 2029 days of placement: longest ever reported interval between drug-eluting stent placement and very late thrombosis. Future Cardiology 7:6, 745-748
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Michael Mahmoudi, Cedric Delhaye, Ron Waksman. (2011) Safety and efficacy of drug-eluting stents and bare metal stents in acute coronary syndrome. Cardiovascular Revascularization Medicine 12:6, 385-390
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Nupura Krishnadev, Farzin Forooghian, Catherine Cukras, Wai Wong, Leorey Saligan, Emily Y. Chew, Robert Nussenblatt, Frederick Ferris, Catherine Meyerle. (2011) Subconjunctival sirolimus in the treatment of diabetic macular edema. Graefe's Archive for Clinical and Experimental Ophthalmology 249:11, 1627-1633
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Soon Yong Suh, Kyoung Hoon Lee, Jeonggeun Moon, Woong Chol Kang, Seung Hwan Han, Tae Hoon Ahn, Eak Kyun Shin. (2011) Comparison of efficacy between paclitaxel-eluting stents with different polymers in terms of major adverse cardiac events and stent thrombosis up to 12months of clinical follow-up. International Journal of Cardiology 152:3, 392-395
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Alexander Sheehy, Steve Hsu, Irene Sinn, Julie Tai, Frank D. Kolodgie, Gaku Nakazawa, Saami K. Yazdani, Shawn Chin Quee, Renu Virmani, Igor Polyakov. (2011) Vascular response to coronary artery stenting in mature and juvenile swine. Cardiovascular Revascularization Medicine 12:6, 375-384
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João Brito, Manuel Almeida, Rui Campante Teles, Pedro Sousa, João Abecasis, Rita Calé, Pedro Gonçalves, Luís Raposo, Miguel Mendes. (2011) Outcomes of drug-eluting stents compared to bare-metal stents in ST-segment elevation acute myocardial infarction. Revista Portuguesa de Cardiologia 30:11, 813-819
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Joanna Wykrzykowska, Patrick Serruys, Pawel Buszman, Axel Linke, Thomas Ischinger, Volker Klauss, Franz Eberli, Roberto Corti, William Wijns, Marie-Claude Morice, Carlo Di Mario, Robert-Jan Van Geuns, Gerrit-Anne Van Es, Peter Juni, Stephan Windecker. (2011) The three year follow-up of the randomised “all-comers” trial of a biodegradable polymer biolimus-eluting stent versus permanent polymer sirolimus-eluting stent (LEADERS). EuroIntervention 7:7, 789-795
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Saami Yazdani, Marc Vorpahl, Masataka Nakano, Shih-Horng Su, Frank Kolodgie, Renu Virmani. (2011) In vitro and in vivo characterisation of biodegradable polymer-based drug-eluting stent. EuroIntervention 7:7, 835-843
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Pascal Vranckx, Eric Boersma, Scot Garg, Marco Valgimigli, Gerrit-Anne Van Es, Dick Goedhart, Patrick Serruys. (2011) Cardiovascular risk profile of patients included in stent trials; a pooled analysis of individual patient data from randomised clinical trials: insights from 33 prospective stent trials in Europe. EuroIntervention 7:7, 859-871
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Olivier Barthelemy, Gérard Helft, Johanne Silvain, Anne Bellemain-Appaix, Farzin Beygui, Rémi Choussat, Emmanuel Berman, Jean-Philippe Collet, Gilles Montalescot, Jean-Philippe Metzger, Claude Le Feuvre. (2011) One-year clinical outcomes in patients with chronic renal failure treated by percutaneous coronary intervention with drug-eluting stent. Archives of Cardiovascular Diseases
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João Brito, Manuel Almeida, Rui Campante Teles, Pedro Sousa, João Abecasis, Rita Calé, Pedro Gonçalves, Luís Raposo, Miguel Mendes. (2011) Outcomes of drug-eluting stents compared to bare-metal stents in ST-segment elevation acute myocardial infarction. Revista Portuguesa de Cardiologia (English Edition) 30:11, 813-819
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Daniela S. Couto, Luis Perez-Breva, Pedro Saraiva, Charles L. Cooney. (2011) Lessons from innovation in drug-device combination products. Advanced Drug Delivery Reviews
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F. Cortazar, M. Z. Molnar, T. Isakova, M. E. Czira, C. P. Kovesdy, D. Roth, I. Mucsi, M. Wolf. (2011) Clinical Outcomes in Kidney Transplant Recipients Receiving Long-Term Therapy With Inhibitors of the Mammalian Target of Rapamycin. American Journal of Transplantationno-no
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Hector M. Garcia-Garcia, Scot Garg, Salvatore Brugaletta, Roberto Diletti, Eun-Seok Shin, Patrick W. Serruys. 2011. Research Utility of Intravascular Ultrasound. , 109-136.
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P. W. Serruys, H. M. Garcia-Garcia, Y. Onuma. (2011) From metallic cages to transient bioresorbable scaffolds: change in paradigm of coronary revascularization in the upcoming decade?. European Heart Journal
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Emilio Lorenzo, Giannignazio Carbone, Luigi Sauro, Alfredo Casafina, Michele Capasso, Rosario Sauro. (2011) Bare-Metal Stents Versus Drug-Eluting Stents for Primary Angioplasty: Long-Term Outcome. Current Cardiology Reports 13:5, 459-464
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M. T. Abate, J. Kaur, H. Suh, F. Darras, A. Mani, E. P. Nord. (2011) The Use of Drug-Eluting Stents in the Management of Transplant Renal Artery Stenosis. American Journal of Transplantation 11:10, 2235-2241
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MARGO KLOMP, MARCEL A.M. BEIJK, PETER DAMMAN, PIER WOUDSTRA, KAREL T. KOCH, JAN G.P. TIJSSEN, ROBBERT J. DE WINTER. (2011) Three-Year Clinical Follow-Up of an Unselected Patient Population Treated with the Genous Endothelial Progenitor Cell Capturing Stent. Journal of Interventional Cardiology 24:5, 442-449
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Jochem van Werkum, Thea Godschalk, Tom Oirbans, Jurriën ten Berg. (2011) Coronary stent thrombosis: incidence, predictors and triggering mechanisms. Interventional Cardiology 3:5, 581-588
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Usman Baber, Roxana Mehran, Samin K. Sharma, Somjot Brar, Jennifer Yu, Jung-Won Suh, Hyo-Soo Kim, Seung-Jung Park, Adnan Kastrati, Antoinette de Waha, Prakash Krishnan, Pedro Moreno, Joseph Sweeny, Michael C. Kim, Javed Suleman, Robert Pyo, Jose Wiley, Jason Kovacic, Annapoorna S. Kini, George D. Dangas. (2011) Impact of the Everolimus-Eluting Stent on Stent Thrombosis. Journal of the American College of Cardiology 58:15, 1569-1577
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Daisuke Kamoi, Hideki Ishii, Hiroshi Takahashi, Toru Aoyama, Takanobu Toriyama, Miho Tanaka, Yoshihiro Kawamura, Kazuhiro Kawashima, Daiji Yoshikawa, Tetsuya Amano, Tadayuki Uetani, Tatsuaki Matsubara, Toyoaki Murohara. (2011) Sirolimus- vs. paclitaxel-eluting stent to coronary intervention in dialysis patients. International Journal of Cardiology
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KISHORE J. HARJAI, SUDHAKAR SATTUR, PAMELA ORSHAW, JUDY BOURA. (2011) Long-Term Safety and Effectiveness of Drug-Eluting Stents Compared to Bare Metal Stents following Successful PCI in Non-ST-Elevation Myocardial Infarction: Findings from the Guthrie Health Off-Label StenT (GHOST) Registry. Journal of Interventional Cardiologyno-no
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Lin Zhang, Jinzhou Zhu, Run Du, Zhenbin Zhu, Jing Zhang, Wei Han, Ruiyan Zhang. (2011) Effect of recombinant human SDF-1a on re-endothelialization after sirolimus-eluting stent implantation in rabbit aorta abdominalis. Life Sciences
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Tae-Won Seo. (2011) Numerical Study of Flow Pattern and Drug Deposition in Drug-Eluting Stent. Transactions of the Korean Society of Mechanical Engineers B 35:10, 1053-1060
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E. G. Marcos, A. C. Fonseca, S. H. Hofma. (2011) Bridging therapy for early surgery in patients on dual antiplatelet therapy after drug-eluting stent implantation. Netherlands Heart Journal 19:10, 412-417
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Kensaku Nishihira, Kinta Hatakeyama, Nehiro Kuriyama, Katsumasa Nomura, Yusuke Fukushima, Yohei Inoue, Tatsuya Nakama, Daigo Mine, Shuichirou Sagara, Keiichi Ashikaga, Akihiko Matsuyama, Kazuo Kitamura, Yoshisato Shibata, Yujiro Asada. (2011) Presence of older thrombus in patients with late and very late drug-eluting stent thrombosis. Journal of Cardiology
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Elif Kaya, Alessandro Cuneo, Matthias Hochadel, Claus Jünger, Wibke Stepper, Peter Bramlage, Karl-Heinz Kuck, Christoph A. Nienaber, Jochen Senges, Lars Eckardt, Ulrich Tebbe, Holger Reinecke. (2011) Impact of chronic kidney disease on the prognosis of patients undergoing percutaneous coronary interventions using drug-eluting stents. Clinical Research in Cardiology
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Gaku Nakazawa. (2011) Stent thrombosis of drug eluting stent: Pathological perspective. Journal of Cardiology 58:2, 84-91
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Tadateru Takayama, Takafumi Hiro, Atsushi Hirayama. (2011) Stent thrombosis and drug-eluting stents. Journal of Cardiology 58:2, 92-98
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Alejandro Diego, Armando Pérez de Prado, Carlos Cuellas, Claudia Pérez-Martínez, Manuel Gonzalo-Orden, Jose R. Altonaga, Antonio de Miguel, Marta Regueiro, Jose Ajenjo, Fernando Sánchez-Lasheras, Ángel Álvarez-Arenal, Felipe Fernández-Vázquez. (2011) La reestenosis en el stent depende del daño vascular inducido. ¿Son válidos los modelos experimentales actuales de análisis de los stents farmacoactivos?. Revista Española de Cardiología 64:9, 745-751
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Kailash Prasad. (2011) Do Statins have a Role in Reduction/Prevention of Post-PCI Restenosis?. Cardiovascular Therapeuticsno-no
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Woong Chol Kang, Yae Min Park, Kwen-Chul Shin, Chan Il Moon, Kyounghoon Lee, Seung Hwan Han, Mi Seung Shin, Jeonggeun Moon, Taehoon Ahn, Eak Kyun Shin. (2011) Comparison of edge vascular response after sirolimus- and paclitaxel-eluting stent implantation. International Journal of Cardiology
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Alejandro Diego, Armando Pérez de Prado, Carlos Cuellas, Claudia Pérez-Martínez, Manuel Gonzalo-Orden, Jose R. Altonaga, Antonio de Miguel, Marta Regueiro, Jose Ajenjo, Fernando Sánchez-Lasheras, Ángel Álvarez-Arenal, Felipe Fernández-Vázquez. (2011) Instent Restenosis Related to Vessel Injury Score Degree. Are Current Experimental Models Valid for Drug-Eluting Stents Analysis?. Revista Española de Cardiología (English Edition) 64:9, 745-751
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Eva Dazert, Michael N Hall. (2011) mTOR signaling in disease. Current Opinion in Cell Biology
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HIROKI ITO, JAMES B. HERMILLER, MANEJEH YAQUB, WILLIAM NEWMAN, POORNIMA SOOD, JOHN C. WANG, LOUIS CANNON, JAMES E. MADDUX, KRISHNANKUTTY SUDHIR, GREGG W. STONE. (2011) Performance of Everolimus-Eluting versus Paclitaxel-Eluting Coronary Stents in Small Vessels: Results from the SPIRIT III and SPIRIT IV Clinical Trials. Journal of Interventional Cardiologyno-no
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Ankur Raval, Jigisha Parikh, Chhaya Engineer. (2011) Mechanism and in Vitro Release Kinetic Study of Sirolimus from a Biodegradable Polymeric Matrix Coated Cardiovascular Stent. Industrial & Engineering Chemistry Research 50:16, 9539-9549
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Song Li, Jeffrey J.D. Henry. (2011) Nonthrombogenic Approaches to Cardiovascular Bioengineering. Annual Review of Biomedical Engineering 13:1, 451-475
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Brian P. Timko, Kathryn Whitehead, Weiwei Gao, Daniel S. Kohane, Omid Farokhzad, Daniel Anderson, Robert Langer. (2011) Advances in Drug Delivery. Annual Review of Materials Research 41:1, 1-20
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Sebastian Kufner, Steffen Massberg, Michael Dommasch, Robert A. Byrne, Klaus Tiroch, Sabine Ranftl, Massimiliano Fusaro, Albert Schömig, Adnan Kastrati, Julinda Mehilli, . (2011) Angiographic outcomes with biodegradable polymer and permanent polymer drug-eluting stents. Catheterization and Cardiovascular Interventions 78:2, 161-166
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LOIC BELLE, MICHAEL MAHMOUDI, CEDRIC DELHAYE, ITSIK BEN-DOR, GABRIEL MALUENDA, MICHAEL A. GAGLIA Jr., REBECCA TORGUSON, LOWELL F. SATLER, AUGUSTO D. PICHARD, RON WAKSMAN. (2011) Do Patients with Drug-Eluting Stent Thrombosis Have a Similar Prognosis to Patients Presenting with ST-Elevation Myocardial Infarction of de novo Lesions?. Journal of Interventional Cardiology 24:4, 320-325
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Mario Sergio Julio Cerci, Juliano Julio Cerci, Rodrigo Julio Cerci, Carlos Cunha Pereira Neto, Evelinda Trindade, Dominique Delbeke, Claudio L. Pereira da Cunha, João Vicente Vitola. (2011) Myocardial Perfusion Imaging Is a Strong Predictor of Death in Women. JACC: Cardiovascular Imaging 4:8, 880-888
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Tae-Hyun Yang, Doo-Il Kim, Han-Young Jin, Young-Wan Cho, Sang Ryul Chung, Dong-Kie Kim, Yong-Bok Kim, Jae-Sik Jang, Ung Kim, Sang-Hoon Seol, Dae-Kyeong Kim, Dong-Soo Kim. (2011) “Angiographic late catch-up” phenomenon after sirolimus-eluting stent implantation. International Journal of Cardiology
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Arturo Giordano, Alfredo Romano. (2011) Inhibition of human in-stent restenosis: a molecular view. Current Opinion in Pharmacology 11:4, 372-377
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Christopher Kaufmann, Gopinath Mani, Denes Marton, David Johnson, C. Mauli Agrawal. (2011) Long-term stability of self-assembled monolayers on electropolished L605 cobalt chromium alloy for stent applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials 98B:2, 280-289
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Margo Klomp, Marcel A. Beijk, Chetan Varma, Jacques J. Koolen, Emmanuel Teiger, Gert Richardt, Florian Bea, Nan van Geloven, Niels J. Verouden, Yu Kwan Chan, Pier Woudstra, Peter Damman, Jan G. Tijssen, Robbert J. de Winter. (2011) 1-Year Outcome of TRIAS HR (TRI-Stent Adjudication Study–High Risk of Restenosis). JACC: Cardiovascular Interventions 4:8, 896-904
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, Timm Bauer, Christoph A. Nienaber, Ibrahim Akin, Karl-Heinz Kuck, Matthias Hochadel, Jochen Senges, Thomas Fetsch, Ulrich Tebbe, Stefan N. Willich, Jürgen Stumpf, Georg V. Sabin, Sigmund Silber, Gert Richardt. (2011) Comparison between on-label versus off-label use of drug-eluting coronary stents in clinical practice: results from the German DES.DE-Registry. Clinical Research in Cardiology 100:8, 701-709
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Christine K Kissel, Christoph Kaiser. (2011) The BASKET study program: continued evaluation of the efficacy and safety of drug-eluting stents. Interventional Cardiology 3:4, 461-466
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Mohammad Almalla, Jörg W. Schröder, Verena Pross, Emilia Stegemann, Nikolaus Marx, Rainer Hoffmann. (2011) Everolimus-Eluting Versus Paclitaxel-Eluting Stents for Treatment of Bare Metal Stent Restenosis. The American Journal of Cardiology 108:4, 518-522
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James A Shand, Vivek Kodoth, Ian BA Menown. (2011) Novel stent and drug elution technologies. Interventional Cardiology 3:4, 473-481
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Daisuke Yoshino, Masaaki Sato. (2011) Design Method of Self-expanding Stent Suitable for Diverse Clinical Manifestation Based on Mechanical Properties. Cardiovascular Engineering and Technology
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Charlie C-T Hsu, John A Rophael, Reza Mofidi, Gigi NC Kwan, Mieke L van Driel, Charlie C-T Hsu. 2011. Percutaneous transluminal arterial angioplasty versus stenting for infrapopliteal arterial lesions in critical limb ischaemia. .
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Margo Klomp, Peter Damman, Marcel A. M. Beijk, Sigmund Silber, Manfred Grisold, Expedito E. Ribeiro, Harry Suryapranata, Jaroslaw Wòjcik, Kui Hian Sim, Jan G. P. Tijssen, Robbert J. Winter. (2011) Applying the National Institute for Clinical Excellence criteria to patients treated with the Genous™ Bio-engineered R stent™: a sub-study of the e-HEALING (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth) worldwide registry. Heart and Vessels
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Feng Qian, Edward L. Hannan, Laurent G. Glance, Charles E. Phelps, Frederick S. Ling, Peter J. Veazie. (2011) Coronary stent use in New York State in the drug-eluting stent era. Journal of Evaluation in Clinical Practiceno-no
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Antoinette Waha, Alban Dibra, Sebastian Kufner, Dietrich Baumgart, Manel Sabate, Aleardo Maresta, Albert Schömig, Adnan Kastrati. (2011) Long-term outcome after sirolimus-eluting stents versus bare metal stents in patients with Diabetes mellitus: a patient-level meta-analysis of randomized trials. Clinical Research in Cardiology 100:7, 561-570
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Kosei Tanaga, Keiichiro Miura, Takahiro Kageyama, Yoshitake Nakamura, Toshihisa Inoue, Kigen Jo, Takayasu Ishikawa, Akira Miyazaki. (2011) Restenosis after implantation of sirolimus-eluting stent begins suddenly, shows short term progression, and stops suddenly. Journal of Cardiology 58:1, 26-31
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Daniel Chamié, Alexandre Abizaid, J. Ribamar Costa, Fausto Feres, J. Fábio Almiro da Silva, Luiz Alberto P. Mattos, Rodolfo Staico, Ricardo A. Costa, Andréa Abizaid, Luiz Fernando L. Tanajura, Amanda G. M. R. Sousa, J. Eduardo Sousa. (2011) Serial angiographic and intravascular ultrasound evaluation to interrogate the presence of late “catch-up” phenomenon after cypher® sirolimus-eluting stent implantation. The International Journal of Cardiovascular Imaging 27:6, 867-874
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Aida Ribera, Ignacio Ferreira-González, Bruno García del Blanco, Josep R. Marsal, Purificación Cascant, Gerard Martí, Ángel R. Cequier, Joan Antoni Gómez-Hospital, Eduard Fernandez-Nofrerías, Xavier Carrillo, M. Carmen López-Pérez, Josep Navarro, Rafael Raso, David García-Dorado, Gaietà Permanyer-Miralda. (2011) Drug-eluting stents for off-label indications in real clinical world: Evidence based or ‘intuition’ based clinical practice?. International Journal of Cardiology
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Maria Radu, Erik Jørgensen, Henning Kelbæk, Steffen Helqvist, Lene Skovgaard, Kari Saunamäki. (2011) Optical coherence tomography at follow-up after percutaneous coronary intervention: relationship between procedural dissections, stent strut malapposition and stent healing. EuroIntervention 7:3, 353-361
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Masato Nakamura. (2011) Review of the everolimus-eluting coronary stent system. Interventional Cardiology 3:3, 299-307
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Masanori Yamamoto, Masamichi Takano, Daisuke Murakami, Toru Inami, Nobuaki Kobayashi, Sigenobu Inami, Kentaro Okamatsu, Takayoshi Ohba, Chikao Ibuki, Noritake Hata, Yoshihiko Seino, Ik-Kyung Jang, Kyoichi Mizuno. (2011) The possibility of delayed arterial healing 5 years after implantation of sirolimus-eluting stents: Serial observations by coronary angioscopy. American Heart Journal 161:6, 1200-1206
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Thomas Pilgrim, Lorenz Räber, Andreas Limacher, Lukas Löffel, Peter Wenaweser, Stéphane Cook, Jean-Christophe Stauffer, Mario Togni, Rolf Vogel, Ali Garachemani, Aris Moschovitis, Ahmed A. Khattab, Christian Seiler, Bernhard Meier, Peter Jüni, Stephan Windecker. (2011) Comparison of Titanium-Nitride-Oxide–Coated Stents With Zotarolimus-Eluting Stents for Coronary Revascularization. JACC: Cardiovascular Interventions 4:6, 672-682
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Juan Luis Gutiérrez-Chico, Evelyn Regar, Robert-Jan van Geuns, Scot Garg, Carl Schultz, Nicolas van Mieghem, Henricus Duckers, Patrick W Serruys. (2011) Moxy® drug-coated balloon: a novel device for the treatment of coronary and peripheral vascular disease. EuroIntervention 7:2, 274-277
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Giora Weisz, Jeffrey W. Moses, Paul S. Teirstein, David R. Holmes, Albert E. Raizner, Lowell F. Satler, Gregory Mishkel, Robert L. Wilensky, Patrick Wang, Richard E. Kuntz, Jeffrey J. Popma, Martin B. Leon. (2007) Safety of Sirolimus-Eluting Stenting and Its Effect on Restenosis in Patients With Unstable Angina Pectoris (a SIRIUS Substudy). The American Journal of Cardiology 99:8, 1044-1050
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Pierfrancesco Agostoni, John Cosgrave, Giuseppe G.L. Biondi-Zoccai, Giuseppe M. Sangiorgi, Lei Ge, Gloria Melzi, Simon Corbett, Flavio Airoldi, Matteo Montorfano, Alaide Chieffo, Iassen Michev, Mauro Carlino, Antonio Colombo. (2007) Angiographic Analysis of Pattern of Late Luminal Loss in Sirolimus- and Paclitaxel-Eluting Stents. The American Journal of Cardiology 99:5, 593-598
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Tomonori Itoh, Hiroshi Nonogi, Shunichi Miyazaki, Akira Itoh, Satoshi Daikoku, Isao Morii, Yoichi Goto, for the 3D-CAT investigators. (2004) Local Delivery of Argatroban for the Prevention of Restenosis After Coronary Balloon Angioplasty. Circulation Journal 68:7, 615-622
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Mitsuharu TSUURA, Tomoaki TERADA, Osamu MASUO, Tomoyuki TSUMOTO, Hiroo YAMAGA, Toru ITAKURA, Hiroyuki MATSUMOTO, Genhachi HYOUTANI, Hiroshi MORIWAKI, Seiji HAYASHI. (2004) Clinical Results and Problems of PTA/Stenting for Intracranial Atherosclerotic Stenoses. Surgery for Cerebral Stroke 32:4, 286-291
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Harry C. Lowe, Robert S. Schwartz, Briain D. Mac Neill, Ik-Kyung Jang, Motoya Hayase, Campbell Rogers, Stephen N. Oesterle. (2003) The porcine coronary model of in-stent restenosis: Current status in the era of drug-eluting stents. Catheterization and Cardiovascular Interventions 60:4, 515-523
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