Images in Clinical Medicine
Von Recklinghausen's Disease and Breast Cancer
N Engl J Med 2005; 352:1799April 28, 2005
- Article
A 74-year-old woman with a history of von Recklinghausen's disease presented with infiltrating lobular carcinoma of the left breast (T2N0M0 [stage IB], according to the tumor–node–metastasis [TNM] staging system). On physical examination, the patient had innumerable cutaneous neurofibromas (Panels A and B). Of the patient's three children (twin daughters and a son), all had inherited the condition, which is also called neurofibromatosis 1. One of her daughters had died at the age of 12 years from complications of a viral illness, and both her other daughter and her son had died at the age of 38 from cancer. The patient's breast tumor was both estrogen-receptor–positive and progesterone-receptor–positive. She underwent a modified radical mastectomy and was subsequently treated with tamoxifen. During the past three years, there has been no evidence of a recurrence of the tumor, and the patient has had no other complications.
Juan G. Posada, M.D.
Carl G. Chakmakjian, D.O.
Scott and White Memorial Hospital and Clinic, Temple, TX 76508- Citing Articles (2)
Citing Articles
1
Yidong Zhou, Bo Pan, Feng Mao, Qingli Zhu, Zhen Huo, Hongyan Wang, Feng Cai, Zhiyong Liang, Changjun Wang, Yanna Zhang, Qiang Sun. (2011) A Hidden Breast Lump Covered by Nipple Appendices in a Patient with von Recklinghausen Disease: A Case Report and Review of the Literature. Clinical Breast Cancer
CrossRef2
Nikolaos S. Salemis, Georgios Nakos, Dimitrios Sambaziotis, Stavros Gourgiotis. (2010) Breast cancer associated with type 1 neurofibromatosis. Breast Cancer 17:4, 306-309
CrossRef
