Editorial

Expression of Concern

Expression of Concern: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13

Gregory D. Curfman, M.D., Stephen Morrissey, Ph.D., and Jeffrey M. Drazen, M.D.

N Engl J Med 2006; 354:638February 9, 2006

Article

In the issue of April 26, 2001, we published a study by Jon Sudbø et al.1 Figures 3B and 3C of that article, which purport to represent two different patients and stages of oral epithelial dysplasia, are in fact different magnifications of the same photomicrograph. Because the results of another study by Dr. Sudbø,2 published in the issue of April 1, 2004, were derived from the same subjects followed through the same database, we have similar concerns. We have informed the director of Dr. Sudbø's institution, the Radiumhospitalet in Oslo, Norway, and await the results of his investigation.

This editorial was published on January 20, 2006, at www.nejm.org.

References

References

1. 1

   Sudbo J, Kildal W, Risberg B, et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-1278
   Full Text | Web of Science | Medline

2. 2

   Sudbo J, Lippman SM, Lee JJ, et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-1413
   Full Text | Web of Science | Medline

Citing Articles (4)

Citing Articles

1. 1

   Darrel P. Francis. (2012) How easily can omission of patients, or selection amongst poorly-reproducible measurements, create artificial correlations? Methods for detection and implications for observational research design in cardiology. International Journal of Cardiology
   CrossRef

2. 2

   Robert J. Cabay, Thomas H. Morton, Joel B. Epstein. (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. Journal of Oral Pathology & Medicine 36:5, 255-261
   CrossRef

3. 3

   Curfman, Gregory D., Morrissey, Stephen, Drazen, Jeffrey M., . (2006) Retraction: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13. New England Journal of Medicine 355:18, 1927-1927
   Full Text | Original Article 1 | Original Article 2

4. 4

   Giovanni Lodi, Andrea Sardella, Cristina Bez, Federica Demarosi, Antonio Carrassi, Giovanni Lodi. 2006. Interventions for treating oral leukoplakia. .
   CrossRef