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Correspondence

Isolated Systolic Hypertension in the Elderly

N Engl J Med 2007; 357:2307-2309November 29, 2007

Article

To the Editor:

Home blood-pressure measurement with the use of an automatic, portable, battery-operated device is easily learned by patients and is an inexpensive way to confirm (or cast doubt on) hypertension detected in the office setting. The elderly man described by Chobanian (Aug. 23 issue)1 in his Clinical Practice article might prove to be normotensive with home blood-pressure measurement, in which case he would not need medication. If hypertension were confirmed by home blood-pressure measurment, lower measurements recorded in his blood-pressure diary after institution of therapy would provide excellent confirmation of a favorable drug effect. Both American and European hypertension societies have endorsed home blood-pressure measurement as an adjunct to conventional office blood-pressure measurement,2,3 especially in identifying white-coat and masked hypertension. This simple and inexpensive technique should be considered in the initial evaluation and long-term care of most patients with hypertension.

Irwin Hoffman, M.D.
Lovelace Medical Center, Albuquerque, NM 87107

3 References
  1. 1

    Chobanian AV. Isolated systolic hypertension in the elderly. N Engl J Med 2007;357:789-796
    Full Text | Web of Science | Medline

  2. 2

    Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003;42:1206-1252
    CrossRef | Web of Science | Medline

  3. 3

    O'Brien E, Asmar R, Beilin L, et al. European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens 2003;21:821-848
    CrossRef | Web of Science | Medline

To the Editor:

Although the treatment of hypertension is currently centered on absolute blood pressure, it is worth discussing a relatively new definition of hypertension.1 It uses the causes of high blood pressure to stratify the extent of hypertension. According to this definition, “normal” blood pressure is a pressure of approximately 115/75 mm Hg, with no cardiovascular disease, few cardiovascular risk factors, no early disease markers, and no end-organ damage. “Stage 1” hypertension includes intermittent blood-pressure elevations or early cardiovascular disease, several cardiovascular risk factors, and the presence of early disease markers but no end-organ disease. “Stage 2” includes sustained blood-pressure elevations or progressive cardiovascular disease, many risk factors, the presence of early disease markers, and early signs of end-organ disease. Patients with marked and sustained blood-pressure elevations or advanced cardiovascular disease, many risk factors, and early disease markers along with overt end-organ disease have “stage 3” hypertension. This definition challenges physicians to treat all aspects of hypertension, not just a blood-pressure value, and should be considered in managing hypertension in all age groups, including the elderly.

John R. Kapoor, M.D., Ph.D.
Stanford University, Stanford, CA 94305

1 References
  1. 1

    Giles TD, Berk BC, Black HR, et al. Expanding the definition and classification of hypertension. J Clin Hypertens (Greenwich) 2005;7:505-512
    CrossRef | Medline

Author/Editor Response

I agree with Hoffman's statement that monitoring blood pressure at home is of value in all persons with elevated office blood-pressure levels in order to rule out the presence of so-called white-coat hypertension. Home blood-pressure measurements are also useful for assessing responses to antihypertensive drug therapy and improving adherence to medications. However, since the patient described in my Clinical Practice article had stage 2 hypertension with considerable elevation of systolic blood pressure, the probability of his having pretreatment systolic levels consistently below 140/90 mm Hg at home would be very low. Accordingly, treatment guidelines recommend initiating therapy quickly and at times starting with two antihypertensive drugs for most persons with stage 2 hypertension.1

Most blood-pressure monitoring devices, including those that are automatic and battery-operated, as mentioned by Hoffman, can be useful for measuring blood pressures at home. Acceptability to the patient is an important consideration, but whatever instrument is selected, it needs to be checked periodically for accuracy in a clinical setting.

The definition of hypertension that Kapoor alludes to uses not only blood-pressure values but also levels of other cardiovascular risk factors and the presence or absence of target-organ damage in the classification scheme. Although such an approach is attractive conceptually, since it considers overall cardiovascular risk, no clinical trial data are available yet to guide the clinician on intervention strategies, were such a classification used. In the absence of clinical trial data, we should continue to use the current classification and to provide treatment with the goal of reducing blood-pressure levels to less than 140/90 mm Hg in most patients with hypertension and to less than 130/80 mm Hg in patients with diabetes, chronic renal disease, coronary heart disease, and congestive heart failure.1-3 In addition, other risk-factor abnormalities should be treated aggressively.

Aram V. Chobanian, M.D.
Boston University Medical Center, Boston, MA 02118

3 References
  1. 1

    Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003;289:2560-2572[Erratum, JAMA 2003;290:197.]
    CrossRef | Web of Science | Medline

  2. 2

    Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007;25:1105-1187[Erratum, J Hypertens 2007;25:1749.]
    CrossRef | Web of Science | Medline

  3. 3

    Rosendorff C, Black HR, Cannon CP, et al. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Circulation 2007;115:2761-2788
    CrossRef | Web of Science | Medline

Citing Articles (1)

Citing Articles

  1. 1

    Mary V. Corrigan, Muralidhar Pallaki. (2009) General Principles of Hypertension Management in the Elderly. Clinics in Geriatric Medicine 25:2, 207-212
    CrossRef