Images in Clinical Medicine

Gingival Hyperplasia Induced by Phenytoin

Sanjay Sharma, M.D., D.M., and S.K. Dasroy, B.D.S.

N Engl J Med 2000; 342:325February 3, 2000

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Figure 1 A 17-year-old boy had generalized tonic–clonic seizures for four years. When the seizures began, a computed tomographic scan of his brain and an electroencephalogram were normal. Treatment with 300 mg of phenytoin per day was subsequently begun and continued unsupervised for a period of two years. Examination revealed coarsening of facial features and severe gingival hyperplasia (Panel A), brisk deep-tendon reflexes, and cerebellar ataxia. Withdrawal of phenytoin was followed by marked regression of the gingival hyperplasia within three months (Panel B); however, ataxia persisted.

Sanjay Sharma, M.D., D.M.
S.K. Dasroy, B.D.S.
Modern Medical Institute, Raipur, India

Citing Articles (3)

Citing Articles

1. 1

   J. Suhanya, Chakshu Aggarwal, Khadijah Mohideen, S. Jayachandran, I. Ponniah. (2010) Cherubism Combined with Epilepsy, Mental Retardation and Gingival Fibromatosis (Ramon Syndrome): A Case Report. Head and Neck Pathology 4:2, 126-131
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2. 2

   2006. Phenytoin and fosphenytoin. , 2813-2820.
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3. 3

   (2000) Current Awareness. Pharmacoepidemiology and Drug Safety 9:3, 257-272
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