Original Article
Prevalence and Clinical Outcome of Hepatitis C Infection in Children Who Underwent Cardiac Surgery before the Implementation of Blood-Donor Screening
N Engl J Med 1999; 341:866-870September 16, 1999
- Abstract
Background and Methods
There are few data on the prevalence and clinical outcome of hepatitis C infection in children. We studied 458 children who underwent cardiac surgery in Munich, Germany, before 1991, when blood-donor screening for hepatitis C was introduced in Germany. Their mean age at first operation was 2.8 years; none of the children had received blood transfusions before or after cardiac surgery, and none of their mothers had antibodies to hepatitis C virus (anti-HCV). We compared these patients with 458 control subjects matched for age and sex.
Results
Sixty-seven (14.6 percent) of the 458 patients who had undergone cardiac surgery had anti-HCV, as compared with 3 (0.7 percent) of the control subjects (P<0.001). At a mean interval of 19.8 years after the first operation, 37 (55 percent) of the 67 patients who were positive for anti-HCV had detectable HCV RNA in their blood. The infection had cleared in the other 30 patients, as evidenced by negative results on three polymerase-chain-reaction analyses performed at six-month intervals. Only 1 of the 37 patients who were positive for HCV RNA had elevated levels of liver enzymes; that patient had severe right-sided congestive heart failure. Of the 17 patients who underwent liver biopsies, only 3 had histologic signs of progressive liver damage. These three patients had additional risk factors: two had congestive heart failure, and the third had also been infected with hepatitis B virus.
Conclusions
Children who had undergone cardiac surgery in Germany before the implementation of blood-donor screening for hepatitis C had a substantial risk of acquiring the infection. However, after about 20 years, the virus had spontaneously cleared in many patients. The clinical course in those still infected seems more benign than would be expected in people infected as adults.
Media in This Article
Table 1
Characteristics of the 458 Patients.Table 2
Blood Products Used during Cardiac Surgery.Article Activity
- Article
The hepatitis C virus (HCV) is the most common cause of hepatitis after blood transfusion. Severe liver damage from hepatitis C has become one of the leading indications for liver transplantation.1-4 Children who have had multiple transfusions as a result of chronic anemia, cancer, or hemophilia, as well as patients who have received extracorporeal membrane oxygenation or long-term parenteral nutrition, are at high risk for HCV infection; the reported prevalence ranges from 10 to 85 percent.5-12 Intrafamilial and mother-to-baby transmission have been reported.13-17
There are few data on the epidemiology, histologic features, and clinical outcome of hepatitis C or risk factors for it in persons who acquired the infection as infants.8,11 A multicenter study found a benign clinical course in children who were infected as infants.18 In contrast, a U.S. study of liver histology in children with post-transfusion hepatitis C showed a high risk of cirrhosis, similar to that in adults.19 In a Japanese study of hepatitis C infection in 161 children after cardiac surgery, the prevalence of infection was 13.6 percent.20 The prevalence of positive tests for antibodies to HCV (anti-HCV) among blood donors is probably higher in Japan and other Asian countries than in Europe and the United States. Thus, such data may not be generalizable.4 We studied the prevalence of and risk factors for HCV infection in children who had undergone cardiac surgery before the introduction of anti-HCV blood-donor screening in Germany. We compared the clinical outcome of infection in these children with that of infection in adults, as reported in other studies.
Methods
Study Subjects and Design
We studied 458 patients (213 female patients and 245 male patients; mean age, 19 years) who had undergone cardiac surgery as infants in Munich, Germany, before 1991. They were followed up in the outpatient clinic of the German Heart Center between October 1996 and December 1997. None of the patients had received blood products before or after surgery, and none had a history of intravenous drug abuse. We ruled out mother-to-baby transmission through an analysis of anti-HCV in the patients' mothers. Thus, it is likely that the HCV infections in the children were due to perioperative blood transfusions. The screening of blood donors for hepatitis C was introduced in Germany in 1991.
We also tested blood samples from 458 control subjects who were matched for age and sex and were representative of the regional population. We screened patients and control subjects for anti-HCV by enzyme immunoassay (EIA II, Abbott, Wiesbaden, Germany) and Western blot assay (recomBlot, Microgen, Munich, Germany). In all subjects, we measured serum levels of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, bilirubin, lactate dehydrogenase, glutamate dehydrogenase, alkaline phosphatase, and albumin, as well as the coagulation time. We used a method that conformed to the recommendations of the Deutsche Gesellschaft für klinische Chemie.21 To establish risk factors for HCV infection, we compared the date and number of operations, sex, age at first operation, and amount and type of blood supply in anti-HCV–positive and anti-HCV–negative patients.
All patients who were positive for anti-HCV were further tested for HCV RNA by reverse-transcription polymerase chain reaction (PCR) (in-house method), HCV genotype (in-house method), and viral load (Amplicor, Roche, Grenzach-Wyhlen, Germany). Seventeen patients with detectable HCV RNA in peripheral blood provided consent for a liver biopsy for the evaluation of possible cell damage. All liver specimens were examined by the same pathologist, who did not have any information about the patients. Biopsy specimens were categorized according to the Ishak scoring system.22
The study protocol was reviewed and approved by the institutional review committee of the Technical University of Munich, Munich, Germany.
Statistical Analysis
We compared age distribution, number of operations, number of blood products used, and biochemical indicators with a combination of the Mann–Whitney U test and the Wilcoxon rank-sum test. We performed a Kruskal–Wallis one-way analysis of variance for Western blot and PCR results.23
Results
Prevalence of HCV and Characteristics of the Patients
Characteristics of the 458 patients are shown in Table 1Table 1
Characteristics of the 458 Patients.. Anti-HCV was found in 67 (14.6 percent) of the patients (34 female and 33 male), as compared with 3 (0.7 percent) of the control subjects (P<0.001). We confirmed positivity for anti-HCV by second-generation enzyme immunoassay and Western blot analysis. Thirty-seven patients were positive for HCV RNA at the follow-up evaluation. The median age at first cardiac surgery was similar among anti-HCV–positive patients and anti-HCV–negative patients (2.8 years in both groups).Blood Products and HCV Infection
Patients who were positive for anti-HCV had significantly more operations than patients who were negative for anti-HCV (2.1 vs. 1.6, P<0.001) and required a higher number of all blood products (20.3 units per patient vs. 7.1 units per patient, P<0.001). For all patients, the average number of blood products required during each cardiac surgery was 9.2 units. Fresh blood was transfused significantly more often in patients who were positive for anti-HCV (3.3 units per patient vs. 2.1 units per patient, P<0.001). Human plasma and whole blood were used more frequently in the patients who were positive for anti-HCV, but the frequency of use did not differ significantly from that in anti-HCV–negative patients. Data on blood products used in the patients are summarized in Table 2Table 2
Blood Products Used during Cardiac Surgery..Clinical Outcome
At the follow-up evaluation, the mean age of the anti-HCV–positive patients was 19.8 years (mean follow-up period, 17 years; range, 12 to 27), as compared with 17.2 years (P=0.004) for the anti-HCV–negative patients (mean follow-up period, 14.4 years; range, 10 to 25). Serum levels of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, bilirubin, lactate dehydrogenase, glutamate dehydrogenase, alkaline phosphatase, and albumin, as well as coagulation time, were within the normal range in all but one patient in each group (Table 3Table 3
Mean Serum Levels of Aspartate Aminotransferase, Alanine Aminotransferase, γ-Glutamyltransferase, and Glutamate Dehydrogenase in Patients Positive for Anti-HCV, According to the Presence of Detectable HCV RNA in the Peripheral Blood.). One eight-year-old patient with a positive test for HCV RNA and with Down's syndrome and persistent pulmonary hypertension after correction of an atrioventricular septal defect had clinical and biochemical evidence of liver disease. He presented with severe hepatosplenomegaly and peripheral edema. His serum levels of alanine aminotransferase and aspartate aminotransferase were 306 U per liter and 259 U per liter, respectively. Consent was not given for a liver biopsy. One patient who was negative for HCV RNA had congestive heart failure after he underwent the Fontan procedure; he had substantially elevated serum levels of γ-glutamyltransferase (97 U per liter).Natural History of the Infection
At a mean interval of 19.8 years (range, 12 to 27) after cardiac surgery, 37 (55 percent) of 67 patients were still positive for HCV RNA (21 patients had genotype 1a, with a mean viral load of 420,000 genome equivalents per milliliter; 15 had genotype 1b, with 552,000 genome equivalents per milliliter; and 1 had genotype 3a, with 5000 genome equivalents per milliliter).
Liver biopsies were performed in 17 patients with detectable HCV RNA a mean of 21.2±4.6 years after the first operation (Table 4Table 4
Histopathological Findings in 17 Patients with HCV RNA.). In 14 patients, the histologic changes were characterized as minimal lymphocytic infiltrates restricted to the portal tracts, with no evidence of liver-cell damage and no lymphocytes within the lobuli. No evidence of fibrosis could be found. In two other patients, both with congestive heart failure, we found periportal fibrosis, stage 2, and sinus ectasia. Increased central venous and right atrial pressure had developed after correction of truncus arteriosus in one of these patients and after the Mustard operation in the other. They both presented with clinically apparent hepatomegaly. Micronodular cirrhosis (stage 6 fibrosis) was detected in another patient, who was infected with HCV, as evidenced by positivity for HCV RNA, and had been infected with hepatitis B, as evidenced by positivity for antibodies to hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B e antigen.In 30 of the 67 patients (45 percent), the virus had cleared, as proved by negative results of three PCR analyses performed at six-month intervals. None of the patients who were initially negative for HCV RNA had positive results on the subsequent assays. Patients who were positive for HCV RNA did not differ significantly from patients who were negative for HCV RNA in regard to serum levels of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, bilirubin, lactate dehydrogenase, glutamate dehydrogenase, alkaline phosphatase, and albumin, as well as coagulation time (Table 3).
Discussion
We found that children who had undergone cardiac surgery in Germany before the implementation of blood-donor screening for hepatitis C were at substantial risk for HCV infection. Anti-HCV was detected in 14.6 percent of our study group, as compared with 0.7 percent of the control group. The presence of anti-HCV reflects ongoing or past infection with HCV, whereas positivity for HCV RNA is evidence of persistent infection. Our data are similar to those on children who underwent cardiac surgery in Japan.20 The risk of HCV infection in our study group was associated with the total number of operations and correlated strongly with the total number of blood products administered. Among the various blood components, only transfusion of fresh blood was associated with an elevated risk of infection. Retrospective analyses have shown an even higher risk of HCV infection for children with thalassemia (55 to 83 percent) and for those with hemophilia (22 to 46 percent), probably as a result of the higher frequency of transfusions in these children.12,24
Since the introduction of programs to screen blood donors, the residual risk of post-transfusion hepatitis C has declined from 1 in 5000 to 1 in 103,000.3,4 Of 120 children who underwent cardiac surgery after 1992, none have become positive for anti-HCV (unpublished data). Other investigators have reported similar findings, although the number of children studied has been small.1,7,20
The natural course of HCV infection in children is not well understood. Children with HCV infection that was acquired from their mothers seem to be at lower risk for progressive liver disease and have a higher spontaneous clearance of HCV than adults.14,15 Eleven percent of children with cancer who were positive for HCV RNA became negative for HCV RNA after a median follow-up of 14 years,8 and in 28 percent of patients with cured childhood leukemia, the virus cleared within a period of 17 years.6 In our study, the virus cleared in 30 (45 percent) of the 67 patients who had been positive for anti-HCV antibodies. Because HCV RNA levels fluctuate and cannot be detected below a concentration of 100 to 1000 genome equivalents per milliliter, we performed two subsequent HCV RNA analyses within two years in each patient who was initially negative for HCV RNA, to rule out persistent infection.25
In our study, past or persistent HCV infection was not associated with clinical or biochemical signs of liver disease. This finding suggests that HCV infection in pediatric patients who are at risk can be detected only by specific screening programs. Almost all the patients who were positive for HCV RNA had normal results on liver-enzyme tests.
In adults, HCV infection is associated with a high risk of cirrhosis and hepatocellular carcinoma.26 Cirrhosis develops within 20 years after infection in about 20 percent of infected adults, and 10 percent of infected adults with cirrhosis have hepatocellular carcinoma. To verify the degree of liver disease, we performed biopsies in 17 of the patients with HCV RNA. At a mean interval of 21.2 years after infection, only three patients had histologic signs of progressive liver disease. All three patients had additional risk factors: two had congestive heart failure, and one had been infected with hepatitis B virus. The remaining 14 patients had only mild periportal inflammation.
All our patients who underwent liver biopsy were infected by HCV of genotype 1, which is thought to be the most aggressive genotype. We did not find severe liver-cell damage, however. These findings suggest that in our study group, chronic hepatitis C was mild and had a low rate of progression even after two decades. In patients infected at a younger age, the interval between blood transfusion and the development of chronic liver disease seems to be longer than in patients infected at an older age.26,27 Our data suggest that elimination of the virus without antiviral treatment is more frequent in patients infected as infants than in those infected as adults.
Our clinical observations and the low rate of sustained response (15 to 25 percent) to interferon treatment underline the weakness of the rationale for early therapeutic intervention with interferon alfa in children.28-34 Because most of our patients were infected with genotype 1a or 1b, both of which are associated with response rates to interferon treatment of less than 10 percent,28 treatment with interferon alfa alone does not seem worthwhile. Combination therapy with interferon alfa and ribavirin might be more effective when treatment is indicated.28,35,36
Presented in part at the Annual Meeting of the German Society of Pediatric Gastroenterology and Nutrition, Kloster Irsee, Germany, May 15–17, 1997; at the Annual Meeting of the European and North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition, Toulouse, France, May 27–30, 1998; at the Annual Meeting of the American Association of the Study of Liver Disease, Chicago, November 6–10, 1998; and at the Annual Meeting of the European Association of Pediatric Cardiology, Dublin, Ireland, June 10–13, 1998.
Supported by the German Heart Center and the Children's University Hospital, Munich, Germany.
Source Information
From the Departments of Pediatric Cardiology and Cardiac Surgery, German Heart Center, Technical University of Munich (M.V., H.M., J.H.); the Children's University Hospital (T.L., A.F.S.) and the Institute of Pathology (B.W.), Ludwig Maximilians University; and the Max von Pettenkofer Institute (G.F., C.K., A.Z., B.L.) — all in Munich, Germany.
Address reprint requests to Dr. Lang at the Children's University Hospital, Pediatric Gastroenterology, Lindwurmstr. 4, D-80337 Munich, Germany, or at thomas.lang@kk-i.med.uni-muenchen.de.
- References
References
1
Chung JL ,Kao JH ,Kong MS ,Yang CP ,Hung IJ ,Lin TY . Hepatitis C and G virus infections in polytransfused children. Eur J Pediatr 1997;156:546-549
CrossRef | Web of Science | Medline2
Conry-Cantilena C ,VanRaden M ,Gibble J , et al. Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection. N Engl J Med 1996;334:1691-1696
Full Text | Web of Science | Medline3
Schreiber GB ,Busch MP ,Kleinman SH ,Korelitz JJ . The risk of transfusion-transmitted viral infections. N Engl J Med 1996;334:1685-1690
Full Text | Web of Science | Medline4
Tobler LH ,Busch MP . History of posttransfusion hepatitis. Clin Chem 1997;43:1487-1493
Web of Science | Medline5
Arico M ,Maggiore G ,Silini E , et al. Hepatitis C virus infection in children treated for acute lymphoblastic leukemia. Blood 1994;84:2919-2922
Web of Science | Medline6
Locasciulli A ,Testa M ,Pontisso P , et al. Prevalence and natural history of hepatitis C infection in patients cured of childhood leukemia. Blood 1997;90:4628-4633
Web of Science | Medline7
Tada K ,Tajiri H ,Kozaiwa K ,Sawada A ,Guo W ,Okada S . Role of screening for hepatitis C virus in children with malignant disease and who undergo bone marrow transplantation. Transfusion 1997;37:641-644
CrossRef | Web of Science | Medline8
Cesaro S ,Petris MG ,Rossetti F , et al. Chronic hepatitis C virus infection after treatment for pediatric malignancy. Blood 1997;90:1315-1320
Web of Science | Medline9
Nelson SP ,Jonas MM . Hepatitis C infection in children who received extracorporeal membrane oxygenation. J Pediatr Surg 1996;31:644-648
CrossRef | Web of Science | Medline10
Jonas MM ,Baron MJ ,Bresee JS ,Schneider LC . Clinical and virologic features of hepatitis C virus infection associated with intravenous immunoglobulin. Pediatrics 1998;98:211-215
Web of Science11
Misra S ,Ament ME ,Vargas JH ,Skoff C ,Reyen L ,Herzog F . Chronic liver disease in children on long-term parenteral nutrition. J Gastroenterol Hepatol 1996;11:S4-S6
Web of Science | Medline12
Resti M ,Azzari C ,Rossi ME ,Vullo C ,Zammarchi E ,Vierucci A . Hepatitis C virus antibodies in a long-term follow-up of beta-thalassaemic children with acute and chronic non-A non-B hepatitis. Eur J Pediatr 1992;151:573-576
CrossRef | Web of Science | Medline13
Takahashi M ,Yamada G ,Tsuji T . Intrafamilial transmission of hepatitis C. Gastroenterol Jpn 1991;26:483-488
Medline14
Bortolotti F ,Resti M ,Giacchino R , et al. Hepatitis C virus infection and related liver disease in children of mothers with antibodies to the virus. J Pediatr 1997;130:990-993
CrossRef | Web of Science | Medline15
Sasaki N ,Matsui A ,Momoi M ,Tsuda F ,Okamoto H . Loss of circulating hepatitis C virus in children who developed a persistent carrier state after mother-to-baby transmission. Pediatr Res 1997;42:263-267
CrossRef | Web of Science | Medline16
Zanetti AR ,Tanzi E ,Paccagnini S , et al. Mother-to-infant transmission of hepatitis C virus. Lancet 1995;345:289-291
CrossRef | Web of Science | Medline17
Gish RG ,Cox KL ,Mizokami M ,Ohno T ,Lau JYN . Vertical transmission of hepatitis C. J Pediatr Gastroenterol Nutr 1996;22:118-119
CrossRef | Web of Science | Medline18
Kage M ,Fujisawa T ,Shiraki K , et al. Pathology of chronic hepatitis C in children. Hepatology 1997;26:771-775
CrossRef | Web of Science | Medline19
Badizadegan K ,Jonas MM ,Ott MJ ,Nelson SP ,Perez-Atayde AR . Histopathology of the liver in children with chronic hepatitis C viral infection. Hepatology 1998;28:1416-1423
CrossRef | Web of Science | Medline20
Matsuoka S ,Tatara K ,Hayabuchi Y ,Nii M ,Mori K ,Kuroda Y . Post-transfusion chronic hepatitis C in children. J Paediatr Child Health 1994;30:544-546
CrossRef | Web of Science | Medline21
Schlebusch H ,Rick W ,Lang M ,Knedel M . Normbereiche der Aktivitäten klinisch wichtiger Enzyme. Dtsch Med Wochenschr 1974;99:765-766
CrossRef | Web of Science | Medline22
Ishak K ,Baptista A ,Bianchi L , et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-699
CrossRef | Web of Science | Medline23
Pocock SJ. Clinical trials: a practical approach. Chichester, England: John Wiley, 1983.
24
Darby SC ,Ewart DW ,Giangrande PLF , et al. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. Lancet 1997;350:1425-1431
CrossRef | Web of Science | Medline25
Fujisawa T ,Komatsu H ,Inui A , et al. Spontaneous remission of chronic hepatitis C in children. Eur J Pediatr 1997;156:773-776
CrossRef | Web of Science | Medline26
Tong MJ ,El-Farra NS ,Reikes AR ,Co RL . Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 1995;332:1463-1466
Full Text | Web of Science | Medline27
Mathurin P ,Moussalli J ,Cadranel JF , et al. Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity. Hepatology 1998;27:868-872
CrossRef | Web of Science | Medline28
Hoofnagle JH ,Di Bisceglie AM . The treatment of chronic viral hepatitis. N Engl J Med 1997;336:347-356
Full Text | Web of Science | Medline29
Lau DTY ,Kleiner DE ,Ghany MG ,Park Y ,Schmid P ,Hoofnagle JH . 10-Year follow-up after interferon-alpha therapy for chronic hepatitis C. Hepatology 1998;28:1121-1127
CrossRef | Web of Science | Medline30
Serfaty L ,Chazouilleres O ,Pawlotsky JM ,Andreani T ,Pellet C ,Poupon R . Interferon alfa therapy in patients with chronic hepatitis C and persistently normal aminotransferase activity. Gastroenterology 1996;110:291-295
CrossRef | Web of Science | Medline31
Matsuoka S ,Mori K ,Nakano O , et al. Efficacy of interferons in treating children with chronic hepatitis C. Eur J Pediatr 1997;156:704-708
CrossRef | Web of Science | Medline32
Poynard T ,Bedossa P ,Chevallier M , et al. A comparison of three interferon alfa-2b regimens for the long-term treatment of chronic non-A, non-B hepatitis. N Engl J Med 1995;332:1457-1462[Erratum, N Engl J Med 1996;334:1143.]
Full Text | Web of Science | Medline33
Davis GL ,Balart LA ,Schiff ER , et al. Treatment of chronic hepatitis C with recombinant interferon alfa. N Engl J Med 1989;321:1501-1506
Full Text | Web of Science | Medline34
Di Bisceglie AM ,Martin P ,Kassianides C , et al. Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. N Engl J Med 1989;321:1506-1510
Full Text | Web of Science | Medline35
McHutchison JG ,Gordon SC ,Schiff ER , et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 1998;339:1485-1492
Full Text | Web of Science | Medline36
Poynard T ,Marcellin P ,Lee SS , et al. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. Lancet 1998;352:1426-1432
CrossRef | Web of Science | Medline
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Hitoshi Tajiri, Ayano Inui, Yuki Kiyohara, Mitsuyoshi Suzuki, Seiichi Kagimoto, Yuri Etani, Toshiaki Shimizu, Tomoo Fujisawa. (2009) Peginterferon alpha-2b and ribavirin for the treatment of chronic hepatitis C in Japanese pediatric and young adult patients: a survey of the Japan Society of Pediatric Hepatology. European Journal of Gastroenterology & Hepatology 21:11, 1256-1260
CrossRef31
Wendy A. Henderson, Ravi Shankar, Jordan J. Feld, Colleen M. Hadigan. (2009) Symptomatic and Pathophysiologic Predictors of Hepatitis C Virus Progression in Pediatric Patients. The Pediatric Infectious Disease Journal 28:8, 724-727
CrossRef32
Hirofumi Uto, Sherri O. Stuver, Katsuhiro Hayashi, Kotaro Kumagai, Fumisato Sasaki, Shuji Kanmura, Masatsugu Numata, Akihiro Moriuchi, Susumu Hasegawa, Makoto Oketani, Akio Ido, Kazunori Kusumoto, Satoru Hasuike, Kenji Nagata, Michinori Kohara, Hirohito Tsubouchi. (2009) Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study. Hepatology 50:2, 393-399
CrossRef33
Elizabeth Kenny-Walsh. (2009) Increased liver-related mortality to hepatitis C viremia defined on the 20th anniversary of its identification. Hepatology 50:2, 349-351
CrossRef34
Hitomi Sezaki, Fumitaka Suzuki, Yusuke Kawamura, Hiromi Yatsuji, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Yuzo Miyakawa, Hiromitsu Kumada. (2009) Poor Response to Pegylated Interferon and Ribavirin in Older Women Infected with Hepatitis C Virus of Genotype 1b in High Viral Loads. Digestive Diseases and Sciences 54:6, 1317-1324
CrossRef35
Regino P González-Peralta, Max R Langham, Joel M Andres, Parvathi Mohan, Paul M Colombani, Mary K Alford, Kathleen B Schwarz. (2009) Hepatocellular Carcinoma in 2 Young Adolescents With Chronic Hepatitis C. Journal of Pediatric Gastroenterology and Nutrition 48:5, 630-635
CrossRef36
Resat Ozaras, Veysel Tahan. (2009) Acute hepatitis C: prevention and treatment. Expert Review of Anti-infective Therapy 7:3, 351-361
CrossRef37
Yoshiyuki Ueno, Jose D Sollano, Geoffrey C Farrell. (2009) Prevention of hepatocellular carcinoma complicating chronic hepatitis C. Journal of Gastroenterology and Hepatology 24:4, 531-536
CrossRef38
Marc G. Ghany, Doris B. Strader, David L. Thomas, Leonard B. Seeff. (2009) Diagnosis, management, and treatment of hepatitis C: An update. Hepatology 49:4, 1335-1374
CrossRef39
James R Rodrigue, William Balistreri, Barbara Haber, Maureen M Jonas, Parvathi Mohan, Jean P Molleston, Karen F Murray, Michael R Narkewicz, Philip Rosenthal, Lesley J Smith, Kathleen B Schwarz, Patricia Robuck, Bruce Barton, Regino P González-Peralta. (2009) Impact of Hepatitis C Virus Infection on Children and Their Caregivers: Quality of Life, Cognitive, and Emotional Outcomes. Journal of Pediatric Gastroenterology and Nutrition 48:3, 341-347
CrossRef40
H. PATEL, E. J. HEATHCOTE. (2009) When to treat and the benefits of treating hepatitis C in patients with haemophilia. Haemophilia 15:1, 20-32
CrossRef41
Norah A. Terrault, Kelly Im, Ross Boylan, Peter Bacchetti, David E. Kleiner, Robert J. Fontana, Jay H. Hoofnagle, Steven H. Belle. (2008) Fibrosis Progression in African Americans and Caucasian Americans With Chronic Hepatitis C. Clinical Gastroenterology and Hepatology 6:12, 1403-1411
CrossRef42
Naim Alkhouri, Nizar N. Zein. (2008) Hepatitis C in children and adolescents: The good, the bad, and the ugly. Current Hepatitis Reports 7:4, 145-151
CrossRef43
Barry A Love, Davendra Mehta, Valentin F Fuster. (2008) Evaluation and management of the adult patient with transposition of the great arteries following atrial-level (Senning or Mustard) repair. Nature Clinical Practice Cardiovascular Medicine 5:8, 454-467
CrossRef44
Anurag Maheshwari, Stuart Ray, Paul J Thuluvath. (2008) Acute hepatitis C. The Lancet 372:9635, 321-332
CrossRef45
Flavia Bortolotti, Gabriella Verucchi, Calogero Cammà, Giuseppe Cabibbo, Lucia Zancan, Giuseppe Indolfi, Raffaella Giacchino, Matilde Marcellini, Maria Grazia Marazzi, Cristiana Barbera, Giuseppe Maggiore, Pietro Vajro, Samuela Bartolacci, Fiorella Balli, Anna Maccabruni, Maria Guido. (2008) Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease. Gastroenterology 134:7, 1900-1907
CrossRef46
Akiko Fujiwara, Kohsaku Sakaguchi, Shinichi Fujioka, Yoshiaki Iwasaki, Tomonori Senoh, Mamoru Nishimura, Masako Terao, Yasushi Shiratori. (2008) Fibrosis progression rates between chronic hepatitis B and C patients with elevated alanine aminotransferase levels. Journal of Gastroenterology 43:6, 484-491
CrossRef47
Evelyn K Hsu, Karen F Murray. (2008) Hepatitis B and C in children. Nature Clinical Practice Gastroenterology & Hepatology 5:6, 311-320
CrossRef48
Flavien Bernardin, Leslie Tobler, Irina Walsh, Joan Dunn Williams, Mike Busch, Eric Delwart. (2008) Clearance of hepatitis C virus RNA from the peripheral blood mononuclear cells of blood donors who spontaneously or therapeutically control their plasma viremia. Hepatology 47:5, 1446-1452
CrossRef49
Sharif B. Missiha, Mario Ostrowski, E. Jenny Heathcote. (2008) Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors. Gastroenterology 134:6, 1699-1714
CrossRef50
Rinaldo Pellicano, Armelle Ménard, Mario Rizzetto, Francis Mégraud. (2008) Helicobacter species and liver diseases: association or causation?. The Lancet Infectious Diseases 8:4, 254-260
CrossRef51
Chao-Hung Hung, Sheng-Nan Lu, Jing-Houng Wang, Shu-Fen Hung, Chien-Hung Chen, Tsung-Hui Hu, Chuan-Mo Lee, Chi-Sin Changchien. (2008) Identified cases of acute hepatitis C from computerized laboratory database: A hospital-based epidemiological and clinical study. Journal of Infection 56:4, 274-280
CrossRef52
Yoko Miyoshi, Hitoshi Tajiri, Mariko Okaniwa, Sousuke Terasawa, Tomoo Fujisawa, Toshiyuki Iizuka, Keiichi Ozono. (2008) Hepatitis C virus infection and interferon therapy in patients with Down syndrome. Pediatrics International 50:1, 7-11
CrossRef53
Cristina Camarero, Natalia Ramos, Alberto Moreno, Angel Asensio, Maria Luisa Mateos, Belen Roldan. (2008) Hepatitis C virus infection acquired in childhood. European Journal of Pediatrics 167:2, 219-224
CrossRef54
Masaaki Mizui, Junko Tanaka, Keiko Katayama, Toshio Nakanishi, Makoto Obayashi, Shiomi Aimitsu, Tomoo Yoshida, Junichi Inoue, Tatsuji Yokoyama, Keiji Tsuji, Keiko Arataki, Syuji Yamaguchi, Toshio Miura, Mikiya Kitamoto, Eiichi Takezaki, Shigeo Orimen, Tatsurou Sakata, Kouji Kamada, Akira Maruhashi, Tooru Tamura, Toshio Nakamura, Kunio Ishida, Kazushi Teramen, Yuzo Miyakawa, Hiroshi Yoshizawa. (2007) Liver disease in hepatitis C virus carriers identified at blood donation and their outcomes with or without interferon treatment: Study on 1019 carriers followed for 5–10 years. Hepatology Research 37:12, 994-1001
CrossRef55
Karen H Seal, Alex Monto, Lorna Dove, Hui Shen, Eric Vittinghoff, Daniel Tracy, Erica Miller, Eva Lau, Teresa L. Wright. (2007) The Association of Human Immunodeficiency Virus Infection with Spontaneously Resolved Hepatitis C Virus Infection and Level of Viremia Among Injection Drug Users. Digestive Diseases and Sciences 52:12, 3423-3430
CrossRef56
L. T. F. Yeung, T. To, S. M. King, E. A. Roberts. (2007) Spontaneous clearance of childhood hepatitis C virus infection. Journal of Viral Hepatitis 14:11, 797-805
CrossRef57
Alicia Wang, Wendy M. Book, Michael McConnell, Teresa Lyle, Katherine Rodby, William T. Mahle. (2007) Prevalence of Hepatitis C Infection in Adult Patients Who Underwent Congenital Heart Surgery Prior to Screening in 1992. The American Journal of Cardiology 100:8, 1307-1309
CrossRef58
Juan Cristina, María del Pilar Moreno, Gonzalo Moratorio. (2007) Hepatitis C virus genetic variability in patients undergoing antiviral therapy. Virus Research 127:2, 185-194
CrossRef59
Rosângela Teixeira, Luis A. Marcos, Scott L. Friedman. (2007) Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C. Hepatology Research 37:8, 579-595
CrossRef60
Solange Heller, Pedro Valencia-Mayoral. (2007) Treatment of Viral Hepatitis in Children. Archives of Medical Research 38:6, 702-710
CrossRef61
Vinod K. Rustgi. (2007) The epidemiology of hepatitis C infection in the United States. Journal of Gastroenterology 42:7, 513-521
CrossRef62
Peter Ferenci, Stefan Ferenci, Christian Datz, Ingo Rezman, Wilhelm Oberaigner, Reinhild Strauss. (2007) Morbidity and mortality in paid Austrian plasma donors infected with hepatitis C at plasma donation in the 1970s. Journal of Hepatology 47:1, 31-36
CrossRef63
Michal Kori, Orna Flidel-Rimon, Erica Sigler, Eric Shinwell, Esther Granot. (2007) Look-back study of Hepatitis C in teenagers after blood transfusions as neonates. Acta Paediatrica 96:7, 1050-1052
CrossRef64
Björn Fischler. (2007) Hepatitis C virus infection. Seminars in Fetal and Neonatal Medicine 12:3, 168-173
CrossRef65
Douglas B. Nelson. (2007) Hepatitis C virus cross-infection during endoscopy: is it the “tip of the iceberg” or the absence of ice?. Gastrointestinal Endoscopy 65:4, 589-591
CrossRef66
Vito Di Marco, Fabrizio Bronte, Marcello Capra, Calogera Gerardi, Aurelio Maggio, Roberto Malizia, Michele Rizzo. (2007) HCV Clearance Among Hemophiliacs and Beta-Thalassemics. Gastroenterology 132:4, 1634
CrossRef67
R. K. STERLING, C. D. LYONS, R. T. STRAVITZ, V. A. LUKETIC, A. J. SANYAL, M. E. CARR, T. J. SMITH, M. H. HACKNEY, M. J. CONTOS, S. A. MILLS, J. G. KUHN, M. E. NOLTE, M. L. SHIFFMAN. (2007) Percutaneous liver biopsy in adult haemophiliacs with hepatitis C virus: safety of outpatient procedure and impact of human immunodeficiency virus coinfection on the spectrum of liver disease. Haemophilia 13:2, 164-171
CrossRef68
Parvathi Mohan, Camilla Colvin, Chevelle Glymph, Roma R. Chandra, David E. Kleiner, Kantilal M. Patel, Naomi L.C. Luban, Harvey J. Alter. (2007) Clinical Spectrum and Histopathologic Features of Chronic Hepatitis C Infection in Children. The Journal of Pediatrics 150:2, 168-174.e1
CrossRef69
Victor de Lédinghen, Pascale Trimoulet, Paul-Régis Mannant, Francis Dumas, Patrick Champbenoît, Christian Baldit, Juliette Foucher, Muriel Faure, Julien Vergniol, Laurent Castéra, Julien Bertet, Hervé Fleury, Patrice Couzigou, Pierre-Henri Bernard. (2007) Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: Long-term follow-up of 196 patients (4535 patient-years). Journal of Hepatology 46:1, 19-25
CrossRef70
Ausra Stikleryte, Jolanta Griskeviciene, Lars O. Magnius, Kestutis Zagminas, Helene Norder, Arvydas Ambrozaitis. (2006) Characterization of HCV strains in an oncohematological pediatric department reveals little horizontal transmission but multiple introductions by un-screened blood products in the past. Journal of Medical Virology 78:11, 1411-1422
CrossRef71
Robert A. Levine, Schuyler O. Sanderson, Robert Ploutz–Snyder, Frank Murray, Elaine Kay, John Hegarty, Niamh Nolan, Dermot Kelleher, George Mcdonald, J. Conor O’Keane, John Crowe. (2006) Assessment of Fibrosis Progression in Untreated Irish Women With Chronic Hepatitis C Contracted From Immunoglobulin Anti-D. Clinical Gastroenterology and Hepatology 4:10, 1271-1277
CrossRef72
R SOLALAMOGLIA. (2006) Tratamiento de la hepatitis aguda C. Gastroenterología y Hepatología 29, 163-167
CrossRef73
Michael W. Fried, Barbara L. Kroner, Liliana R. Preiss, Kirk Wilhelmsen, James J. Goedert. (2006) Hemophilic Siblings With Chronic Hepatitis C: Familial Aggregation of Spontaneous and Treatment-Related Viral Clearance. Gastroenterology 131:3, 757-764
CrossRef74
Mostafa K. Mohamed, Iman Bakr, Mostafa El-Hoseiny, Naglaa Arafa, Abubakr Hassan, Soheir Ismail, Mohamed Anwar, Mohamed Attala, Claire Rekacewicz, Khaled Zalata, Mohamed Abdel-Hamid, Gamal Esmat, Arnaud Fontanet. (2006) HCV-related morbidity in a rural community of Egypt. Journal of Medical Virology 78:9, 1185-1189
CrossRef75
Carolina Rumbo, Rima L. Fawaz, Sukru H. Emre, Frederick J. Suchy, Nanda Kerkar, Raffaella A. Morotti, Benjamin L. Shneider. (2006) Hepatitis C in Children. Journal of Pediatric Gastroenterology and Nutrition 43:2, 209-216
CrossRef76
Ian W. Udell, Neal R. Barshes, Milton J. Finegold, Timothy C. Lee, Jaymee D. Scott, Beth Carter, Saul Karpen, John A. Goss. (2006) Hepatitis C viral recurrence in a pediatric patient following liver transplantation. Pediatric Transplantation 10:5, 617-622
CrossRef77
Winita Hardikar, Kathleen B Schwarz. (2006) Treatment options for chronic hepatitis B and C infection in children. Expert Review of Anti-infective Therapy 4:4, 583-591
CrossRef78
Dirk Posthouwer, Kathelijn Fischer, Karel J. van Erpecum, Eveline P. Mauser-Bunschoten. (2006) The natural history of childhood-acquired hepatitis C infection in patients with inherited bleeding disorders. Transfusion 46:8, 1360-1366
CrossRef79
Neal R. Barshes, Ian W. Udell, Timothy C. Lee, Christine A. O'Mahony, Saul J. Karpen, Beth A. Carter, John A. Goss. (2006) The natural history of hepatitis C virus in pediatric liver transplant recipients. Liver Transplantation 12:7, 1119-1123
CrossRef80
Manfred Vogt, Barbara Klostermann, Siegmund Braun, Raymonde Busch, John Hess, Gert Frösner, Thomas Lang. (2006) Prevalence and clinical role of GBV-C infection after cardiac surgery in childhood: A study on 414 patients. Journal of Infection 53:1, 43-48
CrossRef81
Barbara Haber. (2006) Hepatitis C, liver transplantation, and why we should consider children separately. Liver Transplantation 12:7, 1042-1043
CrossRef82
Rise Stribling, Norman Sussman, John M. Vierling. (2006) Treatment of Hepatitis C Infection. Gastroenterology Clinics of North America 35:2, 463-486
CrossRef83
Gioacchino Leandro, Alessandra Mangia, Jason Hui, Paolo Fabris, Laura Rubbia–Brandt, Guido Colloredo, Luigi E. Adinolfi, Tarik Asselah, Julie R. Jonsson, Antonina Smedile, Norah Terrault, Valerio Pazienza, Maria Teresa Giordani, Emiliano Giostra, Aurelio Sonzogni, Giuseppe Ruggiero, Patrick Marcellin, Elizabeth E. Powell, Jacob George, Francesco Negro. (2006) Relationship Between Steatosis, Inflammation, and Fibrosis in Chronic Hepatitis C: A Meta-Analysis of Individual Patient Data. Gastroenterology 130:6, 1636-1642
CrossRef84
Manfred Vogt, Mustafa Rifai, Siegmund Braun, Raymonde Busch, John Hess, Gert Frösner, Thomas Lang. (2006) Epidemiology, risk factors and clinical role of TT virus infection in polytransfused patients after cardiac surgery in childhood: Impact of HCV co infection. Journal of Clinical Virology 36:1, 82-83
CrossRef85
Patrick Gerner, Stefan Wirth, Philip Wintermeyer, Alexander Walz, Andreas Jenke. (2006) Prevalence of hepatitis C virus infection in children admitted to an urban hospital. Journal of Infection 52:4, 305-308
CrossRef86
Jordan J. Feld, T. Jake Liang. (2006) Hepatitis C — identifying patients with progressive liver injury. Hepatology 43:S1, S194-S206
CrossRef87
Y. MAOR, D. BASHARI, G. KENET, S. LALEZARI, A. LUBETSKY, J. LUBOSHITZ, J. M. SCHAPIRO, B. AVIDAN, S. BAR-MEIR, U. MARTINOWITZ. (2006) Hepatitis C at the Israeli National Hemophilia Center. Haemophilia 12:1, 68-74
CrossRef88
J. M. Micallef, J. M. Kaldor, G. J. Dore. (2006) Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. Journal of Viral Hepatitis 13:1, 34-41
CrossRef89
Kazuo SHIRAKI. (2006) Infantile liver disease: Carry-over to the adult. 1. Carry-over of infantile viral hepatitis. Mainly on hepatitis B and hepatitis C.. Kanzo 47:2, 71-77
CrossRef90
Hiroshi Yoshizawa, Junko Tanaka, Yuzo Miyakawa. (2006) National Prevention of Hepatocellular Carcinoma in Japan Based on Epidemiology of Hepatitis C Virus Infection in the General Population. Intervirology 49:1-2, 7-17
CrossRef91
Donatella Comparcola, Valerio Nobili, Maria Rita Sartorelli, Matilde Marcellini, Francesca Cainelli, Sandro Vento. (2005) CHILDHOOD HEPATITIS C VIRUS INFECTION.. Journal of Gastroenterology and Hepatology 20:12, 1948-1949
CrossRef92
Theo Heller, Leonard B. Seeff. (2005) Viral load as a predictor of progression of chronic hepatitis C?. Hepatology 42:6, 1261-1263
CrossRef93
R. Iorio, A. Giannattasio, A. Sepe, L. M. Terracciano, R. Vecchione, A. Vegnente. (2005) Chronic Hepatitis C in Childhood: An 18-Year Experience. Clinical Infectious Diseases 41:10, 1431-1437
CrossRef94
NAOMI L.C. LUBAN. (2005) Transfusion Safety: Where Are We Today?. Annals of the New York Academy of Sciences 1054:1, 325-341
CrossRef95
Mostafa K. Mohamed, Mohamed Abdel-Hamid, Nabiel N. Mikhail, Fatma Abdel-Aziz, Ahmed Medhat, Laurence S. Magder, Alan D. Fix, G. Thomas Strickland. (2005) Intrafamilial transmission of hepatitis C in Egypt. Hepatology 42:3, 683-687
CrossRef96
Francesca Fioredda, Anna Rita Gigliotti, Riccardo Haupt, Maria Grazia Calevo, Cinzia Lo Giudice, Laura Bocciardo, Raffaella Giacchino. (2005) HCV Infection in Very-Long-Term Survivors After Cancer Chemotherapy and Bone Marrow Transplantation. Journal of Pediatric Hematology/Oncology 27:9, 481-485
CrossRef97
Valérie A. McLin, William F. Balistreri. (2005) Advances in the treatment of hepatitis C in children and adolescents. Current Hepatitis Reports 4:3, 97-103
CrossRef98
TAKASHI ISHIKAWA, YASUSHI FUKUSHIMA, YUJIRO SHIOBARA, TSUYOSHI KISHIMOTO, SAKIKO TANNO, IKUO SHOJI, TETSURO SUZUKI, TAMANO MATSUI, YASUSHI SHIMADA, TAKAAKI OHYAMA, RYOZO NAGAI, TATSUO MIYAMURA. (2005) Outbreak of hepatitis C virus infection in an outpatient clinic. Journal of Gastroenterology and Hepatology 20:7, 1087-1093
CrossRef99
Georgia B. Nikolopoulou, Marek J. Nowicki, Wenbo Du, James Homans, Alice Stek, Francoise Kramer, Andrea Kovacs. (2005) HCV viremia is associated with drug use in young HIV-1 and HCV coinfected pregnant and non-pregnant women. Addiction 100:5, 626-635
CrossRef100
Stefan Wirth, Heidrun Pieper-Boustani, Thomas Lang, Antje Ballauff, Ulrike Kullmer, Patrick Gerner, Philip Wintermeyer, Andreas Jenke. (2005) Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C. Hepatology 41:5, 1013-1018
CrossRef101
Mark S. Sulkowski, David L. Thomas. (2005) Epidemiology and Natural History of Hepatitis C Virus Infection in Injection Drug Users: Implications for Treatment. Clinical Infectious Diseases 40:s5, S263-S269
CrossRef102
Hiroshi Kamitsukasa, Hideharu Harada, Hideo Tanaka, Michiyasu Yagura, Hajime Tokita, Akira Ohbayashi. (2005) Late liver-related mortality from complications of transfusion-acquired hepatitis C. Hepatology 41:4, 819-825
CrossRef103
Beth A. Plunkett, William A. Grobman. (2005) Routine hepatitis C virus screening in pregnancy: A cost-effectiveness analysis. American Journal of Obstetrics and Gynecology 192:4, 1153-1161
CrossRef104
C. A. Benson, J. E. Kaplan, H. Masur, A. Pau, K. K. Holmes. (2005) Treating Opportunistic Infections among HIV-Infected Adults and Adolescents: Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America. Clinical Infectious Diseases 40:Supplement 3, S131-S235
CrossRef105
Paul H. Hayashi, Adrian M. Di Bisceglie. (2005) The progression of hepatitis B– and C–infections to chronic liver disease and hepatocellular carcinoma: epidemiology and pathogenesis. Medical Clinics of North America 89:2, 371-389
CrossRef106
L. M. Mofenson, J. Oleske, L. Serchuck, R. Van Dyke, C. Wilfert. (2005) Treating Opportunistic Infections among HIV-Exposed and Infected Children: Recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of America. Clinical Infectious Diseases 40:Supplement 1, S1-S84
CrossRef107
(2005) Hepatitis C Virus (HCV). Transfusion Medicine and Hemotherapy 32:3-4, 184-195
CrossRef108
Girish Subba Rao, Jean Pappas Molleston. (2005) Children with hepatitis C. Current Gastroenterology Reports 7:1, 37-44
CrossRef109
Keisuke Kawai, Katsuya Hata, Hiroya Kawai, Hideyuki Takaoka, Yoko Miyata-Fukuoka, Hideaki Okubo, Mitsuhiro Yokoyama. (2005) Pathophysiological Characteristics and Responsiveness to Neurohormonal Antagonism in Idiopathic Dilated Cardiomyopathy Patients With Antihepatitis C Virus Antibody. International Heart Journal 46:3, 407-417
CrossRef110
Baldassarre Martire, Antonia Gentile, Ruggiero Francavilla, Attilio De Santis, Domenico De Mattia. (2005) Successful Treatment with Cyclosporine A of HCV-Driven Chronic Liver Disease Mimicking Autoimmune Hepatitis in a Patient with Common Variable Immunodeficiency. Immunopharmacology and Immunotoxicology 27:4, 535-543
CrossRef111
Frances V. White, Louis P. Dehner. (2004) Viral Diseases of the Liver in Children: Diagnostic and Differential Diagnostic Considerations. Pediatric and Developmental Pathology 7:6, 552-567
CrossRef112
SANGUANSAK RERKSUPPAPHOL, WINITA HARDIKAR, GREGORY J DORE. (2004) Long-term outcome of vertically acquired and post-transfusion hepatitis C infection in children. Journal of Gastroenterology and Hepatology 19:12, 1357-1362
CrossRef113
Micha
l Schwarzinger, Sahar Dewedar, Claire Rekacewicz, Khaled Mahmoud Abd Elaziz, Arnaud Fontanet, Fabrice Carrat, Mostafa Kamal Mohamed. (2004) Chronic hepatitis C virus infection: Does it really impact health-related quality of life? A study in rural Egypt. Hepatology 40:6, 1434-1441
CrossRef114
Regino P. González-Peralta. (2004) Treatment of chronic hepatitis C in children. Pediatric Transplantation 8:6, 639-643
CrossRef115
D. Posthouwer, V. M. Wolters, K. Fischer, R. H. J. Houwen, H. M. Berg, E. P. Mauser-Bunschoten. (2004) Hepatitis C infection in children with haemophilia: a pilot study. Haemophilia 10:6, 722-726
CrossRef116
Doris B. Strader. (2004) Hepatitis C virus among african-american persons. Current Hepatitis Reports 3:4, 129-135
CrossRef117
J. J. Goedert, D. L. Brown, K. Hoots, K. E. Sherman. (2004) Human immunodeficiency and hepatitis virus infections and their associated conditions and treatments among people with haemophilia. Haemophilia 10:s4, 205-210
CrossRef118
Barbara A. Piasecki, James D. Lewis, K. Rajender Reddy, Scarlett L. Bellamy, Steven B. Porter, Robert M. Weinrieb, Donald D. Stieritz, Kyong-Mi Chang. (2004) Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran population. Hepatology 40:4, 892-899
CrossRef119
Aymin Delgado-Borrego, Maureen M. Jonas. (2004) Treatment options for hepatitis C infection in children. Current Treatment Options in Gastroenterology 7:5, 373-379
CrossRef120
M. S. El-Raziky, M. El-Hawary, N. El-Koofy, S. Okasha, M. Kotb, K. Salama, G. Esmat, M. El-Raziky, A. M. Abouzied, H. El-Karaksy. (2004) Hepatitis C virus infection in Egyptian children: single centre experience. Journal of Viral Hepatitis 11:5, 471-476
CrossRef121
Beth A. Plunkett, William A. Grobman. (2004) Elective cesarean delivery to prevent perinatal transmission of hepatitis C virus: A cost-effectiveness analysis. American Journal of Obstetrics and Gynecology 191:3, 998-1003
CrossRef122
Henry Pollack, Zhiying Hou, Austin L. Hughes, William Borkowsky. (2004) Perinatal Transmission and Viral Evolution of Hepatitis C Virus Quasispecies in Infants Coinfected With HIV. JAIDS Journal of Acquired Immune Deficiency Syndromes 36:4, 890-899
CrossRef123
J. Delwaide, N. Bourgeois, C. Gerard, S. De Maeght, F. Mokaddem, E. Wain, B. Bastens, J. Fevery, M. Gehenot, O. Le Moine, J. P. Martinet, G. Robaeys, B. Servais, M. Van Gossum, H. Van Vlierberghe, . (2004) Treatment of acute hepatitis C with interferon alpha-2b: early initiation of treatment is the most effective predictive factor of sustained viral response. Alimentary Pharmacology and Therapeutics 20:1, 15-22
CrossRef124
Pei-Lun Lee, Jing-Houng Wang, Hung-Da Tung, Chuan-Mo Lee, Sheng-Nan Lu. (2004) A higher than expected recovery rate from hepatitis C infection amongst adolescents: a community study in a hepatitis C-endemic township in Taiwan. Transactions of the Royal Society of Tropical Medicine and Hygiene 98:6, 367-372
CrossRef125
D. Siagris, N. Giannakoulas, M. Christofidou, A. Tsamandas, A. Lekkou, K. Thomopoulos, N. Zoumbos, Ch. Labropoulou-Karatza. (2004) Virological, immunological and histological aspects in adult beta-thalassemic patients with chronic hepatitis C virus infection. Liver International 24:3, 204-209
CrossRef126
Aijaz Ahmed, Emmet B Keeffe. (2004) Chronic hepatitis C with normal aminotransferase levels. Gastroenterology 126:5, 1409-1415
CrossRef127
Brian L. Pearlman. (2004) Hepatitis C Infection: A Clinical Review. Southern Medical Journal 97:4, 365-373
CrossRef128
Robert J Fontana, Gregory T Everson, Sony Tuteja, Hugo E Vargas, Mitchell L Shiffman. (2004) Controversies in the management of hepatitis C patients with advanced fibrosis and cirrhosis. Clinical Gastroenterology and Hepatology 2:3, 183-197
CrossRef129
Thomas R. OʼBrien, Gregory Kirk, Mingdong Zhang. (2004) Hepatocellular Carcinoma. The Cancer Journal 10:2, 67-73
CrossRef130
Brian J. McMahon, Thomas W. Hennessy, Carol Christensen, Dana Bruden, Daniel G. Sullivan, Chriss Homan, Heike Deubner, Michael G. Bruce, Stephen Livingston, James Williams, David R. Gretch. (2004) Epidemiology and risk factors for hepatitis C in Alaska Natives. Hepatology 39:2, 325-332
CrossRef131
M. E. Eyster, J. Sanders, J. J. Goedert. (2004) Viral clearance occurs very early during the natural resolution of hepatitis C virus infection in persons with haemophilia. Haemophilia 10:1, 75-80
CrossRef132
Maria Antonietta Casiraghi, Massimo De Paschale, Luisa Roman
CrossRef133
J. Puetz, M. Thrower, R. Kane, J. Bouhasin. (2004) Combination therapy with ribavirin and interferon in a cohort of children with hepatitis C and haemophilia followed at a pediatric haemophilia treatment center. Haemophilia 10:1, 87-93
CrossRef134
Simon A Brown, Louis M Aledort, Christine A Lee. (2003) Molecular challenges and viral diseases. Haemophilia 9:6, 727-737
CrossRef135
Catherine M Meyers, Leonard B Seeff, Catherine O Stehman-Breen, Jay H Hoofnagle. (2003) Hepatitis C and renal disease: an update 1 1Summary of a workshop held October 21 to 22, 2002, in the Lister Hill Auditorium, The National Institutes of Health, Bethesda, MD.. American Journal of Kidney Diseases 42:4, 631-657
CrossRef136
Isabelle Thuret, Florence Lacaille, Danielle Canioni, Bertrand Roquelaure, Gerard Michel, St??phane Blanche. (2003) Histopathology of the liver in adolescents co-infected with HIV and hepatitis C virus. AIDS 17:15, 2265-2267
CrossRef137
Corina Hartman, Drora Berkowitz, Nurit Rimon, Raanan Shamir. (2003) The Effect of Early Treatment in Children with Chronic Hepatitis. Journal of Pediatric Gastroenterology and Nutrition 37:3, 252-257
CrossRef138
Junko Tanaka, Hiromitsu Kumada, Kenji Ikeda, Kazuaki Chayama, Masaaki Mizui, Kunihiko Hino, Keiko Katayama, Junko Kumagai, Yutaka Komiya, Yuzo Miyakawa, Hiroshi Yoshizawa. (2003) Natural histories of hepatitis C virus infection in men and women simulated by the Markov model. Journal of Medical Virology 70:3, 378-386
CrossRef139
Massimo Resti, Paloma Jara, Loreto Hierro, Chiara Azzari, Raffaella Giacchino, Giovanna Zuin, Lucia Zancan, Sabrina Pedditzi, Flavia Bortolotti. (2003) Clinical features and progression of perinatally acquired hepatitis C virus infection. Journal of Medical Virology 70:3, 373-377
CrossRef140
J.Tilman Gerlach, Helmut M Diepolder, Reinhart Zachoval, Norbert H Gruener, Maria-Christina Jung, Axel Ulsenheimer, Winfried W Schraut, C.albrecht Schirren, M Waechtler, M Backmund, Gerd R Pape. (2003) Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance1 1The Bundesministerium für Bildung und Forschung and the European Union, as sponsors of the study, had no role in study design, data collection, analysis, or interpretation or in the writing and the decision to submit the report for publication.. Gastroenterology 125:1, 80-88
CrossRef141
A. J. Freeman, M. G. Law, J. M. Kaldor, G. J. Dore. (2003) Predicting progression to cirrhosis in chronic hepatitis C virus infection. Journal of Viral Hepatitis 10:4, 285-293
CrossRef142
Kathleen B. Schwarz. (2003) Pediatric issues in new therapies for hepatitis B and C. Current Gastroenterology Reports 5:3, 233-239
CrossRef143
William C Oliver, Froukje M Beynen, Gregory A Nuttall, Darrell R Schroeder, Mark H Ereth, Joseph A Dearani, Francisco J Puga. (2003) Blood loss in infants and children for open heart operations: albumin 5% versus Fresh-Frozen plasma in the prime. The Annals of Thoracic Surgery 75:5, 1506-1512
CrossRef144
V. Di Ciommo, P. Russo, L. Rava, L. Caprino. (2003) Interferon alpha in the treatment of chronic hepatitis C in children: a metanalysis. Journal of Viral Hepatitis 10:3, 210-214
CrossRef145
Paloma Jara, Massimo Resti, Loreto Hierro, Raffaella Giacchino, Cristiana Barbera, Lucia Zancan, Carlo Crivellaro, Etienne Sokal, Chiara Azzari, Maria Guido, Flavia Bortolotti. (2003) Chronic Hepatitis C Virus Infection in Childhood: Clinical Patterns and Evolution in 224 White Children. Clinical Infectious Diseases 36:3, 275-280
CrossRef146
Yasunori Sugiyasu, Nobukazu Yuki, Takayuki Nagaoka, Masatoshi Yamashiro, Kunimitsu Kawahara, Kenya Iyoda, Yoshimi Kakiuchi, Akira Kaneko, Keiji Yamamoto, Kazumasa Hikiji, Michio Kato. (2003) Histological improvement of chronic liver disease after spontaneous serum hepatitis C virus clearance. Journal of Medical Virology 69:1, 41-49
CrossRef147
R. P. Myers, K. Patel, S. Pianko, T. Poynard, J. G. McHutchison. (2003) The rate of fibrosis progression is an independent predictor of the response to antiviral therapy in chronic hepatitis C. Journal of Viral Hepatitis 10:1, 16-22
CrossRef148
Andrea Moser, Herwig Lackner, Johann Deutsch, Reinhold Kerbl, Wolfgang Schwinger, Hans Jürgen Dornbusch, Harald H. Kessler, Christian Urban. (2003) Doppelinfektion mit Hepatitis B und C. Spontanverlauf und Ansprechen auf virostatische Therapie bei Kindern nach onkologischen Erkrankungen. Wiener Klinische Wochenschrift 115:1-2, 66-70
CrossRef149
D. Prati. (2002) Transmission of viral hepatitis by blood and blood derivatives: current risks, past heritage. Digestive and Liver Disease 34:11, 812-817
CrossRef150
P. Cacoub, Y. Benhamou. (2002) Place des interférons dans le traitement des infections par les virusde l'hépatite B et de l'hépatite C. La Revue de Médecine Interne 23, 459S-474S
CrossRef151
Maureen M. Jonas. (2002) Children with hepatitis C. Hepatology 36:S1, S173-S178
CrossRef152
Jay H. Hoofnagle. (2002) Course and outcome of hepatitis C. Hepatology 36:S1, S21-S29
CrossRef153
Leonard B. Seeff. (2002) Natural history of chronic hepatitis C. Hepatology 36:S1, S35-S46
CrossRef154
Ding-You Li, Kathleen B. Schwarz. (2002) Immunopathogenesis of Chronic Hepatitis C Virus Infection. Journal of Pediatric Gastroenterology and Nutrition 35:3, 260-267
CrossRef155
W. Kurt Roth, Marijke Weber, Sylvia Buhr, Christian Drosten, Wolfgang Weichert, Walid Sireis, Doris Hedges, Erhard Seifried. (2002) Yield of HCV and HIV-1 NAT after screening of 3.6 million blood donations in central Europe. Transfusion 42:7, 862-868
CrossRef156
C. LEE, G. DUSHEIKO. (2002) The natural history and antiviral treatment of hepatitis C in haemophilia. Haemophilia 8:3, 322-329
CrossRef157
Sandro Vento, Francesca Cainelli. (2002) Does hepatitis C virus cause severe liver disease only in people who drink alcohol?. The Lancet Infectious Diseases 2:5, 303-309
CrossRef158
Winita Hardikar. (2002) Hepatitis C in childhood. Journal of Gastroenterology and Hepatology 17:4, 476-481
CrossRef159
Sami L. Khella, Nizar Souayah. (2002) Hepatitis C: A Review of its Neurologic Complications. The Neurologist 8:2, 101-106
CrossRef160
Voranush Chongsrisawat, Yong Poovorawan. (2002) Management of chronic hepatitis B and C virus infections. The Indian Journal of Pediatrics 69:2, 149-154
CrossRef161
Karen R. Jacobson, Karen Murray, Aglaia Zellos, Kathleen B. Schwarz. (2002) An Analysis of Published Trials of Interferon Monotherapy in Children With Chronic Hepatitis C. Journal of Pediatric Gastroenterology and Nutrition 34:1, 52-58
CrossRef162
J. Macias, A. Sanchez-Quijano, J. A. Pineda, M. A. Abad, A. Rubio, R. Rosa, M. Leal, E. Lissen. (2001) Minimal liver injury in chronic hepatitis C virus infection is associated with low levels of soluble TNF-alpha/Fas receptors and acquisition in childhood. Liver International 21:6, 410-414
CrossRef163
Jaeckel, Elmar, Cornberg, Markus, Wedemeyer, Heiner, Santantonio, Teresa, Mayer, Julika, Zankel, Myrga, Pastore, Giuseppe, Dietrich, Manfred, Trautwein, Christian, Manns, Michael P., . (2001) Treatment of Acute Hepatitis C with Interferon Alfa-2b. New England Journal of Medicine 345:20, 1452-1457
Full Text164
Hoofnagle, Jay H., . (2001) Therapy for Acute Hepatitis C. New England Journal of Medicine 345:20, 1495-1497
Full Text165
K. Messick, J. C. Sanders, J. J. Goedert, M. E. Eyster. (2001) Hepatitis C viral clearance and antibody reactivity patterns in persons with haemophilia and other congenital bleeding disorders. Haemophilia 7:6, 568-574
CrossRef166
Donald K. Strickland, Jesse J. Jenkins, Melissa M. Hudson. (2001) Hepatitis C Infection and Hepatocellular Carcinoma After Treatment of Childhood Cancer. Journal of Pediatric Hematology/Oncology 23:8, 527-529
CrossRef167
Oronzo Ceci, Marcella Margiotta, Fiorino Marello, Ruggiero Francavilla, Pasquale Loizzi, Antonio Francavilla, Angela Mautone, Luigi Impedovo, Enzo Ierardi, Maria Mastroianni, Stefano Bettocchi, Luigi Selvaggi. (2001) Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV-Seronegative Pregnant Women: A 24-Month Prospective Study. Journal of Pediatric Gastroenterology and Nutrition 33:5, 570-575
CrossRef168
David Duncan. (2001) MORTALITY ASSOCIATED WITH HEPATITIS C INFECTION. Evidence-Based Gastroenterology 2:3, 123-125
CrossRef169
Arturo Pereira. (2001) Health and economic consequences of HCV lookback. Transfusion 41:6, 832-839
CrossRef170
Antonello Giovannetti, Francesca Mazzetta, Rossella Coviello, Anna Maria Casadei, Maria Rita Sartorerri, Marco Marziali, Marina Pierdominici, Diego Kuonen, Anna Maria Pesce, Massimo Fiorilli, Fernando Aiuti, Isabella Quinti. (2001) T-Cell Immune Activation in Children with Vertically Transmitted Hepatitis C Virus Infection. Viral Immunology 14:2, 169-179
CrossRef171
Flavia Bortolotti, Raffaele Iorio, Massimo Resti, Gabriella Verucchi, Raffaella Giacchino, Angela Vegnente, Pietro Vajro, Maria Grazia Marazzi, Matilde Marcellini, Cristiana Barbera, Giovanna Zuin, Lucia Zancan, Giuseppe Maggiore. (2001) An Epidemiological Survey of Hepatitis C Virus Infection in Italian Children in the Decade 1990–1999. Journal of Pediatric Gastroenterology and Nutrition 32:5, 562-566
CrossRef172
Eric S. Daar, Henry Lynn, Sharyne Donfield, Edward Gomperts, Margaret W. Hilgartner, W. Keith Hoots, David Chernoff, Steven Arkin, W-Y. Wong, Cheryl A. Winkler. (2001) Relation Between HIV-1 and Hepatitis C Viral Load in Patients With Hemophilia. Journal of Acquired Immune Deficiency Syndromes 26:5, 466-472
CrossRef173
Eric S. Daar, Henry Lynn, Sharyne Donfield, Edward Gomperts, Margaret W. Hilgartner, W. Keith Hoots, David Chernoff, Steven Arkin, W-Y. Wong, Cheryl A. Winkler. (2001) Relation Between HIV-1 and Hepatitis C Viral Load in Patients With Hemophilia. JAIDS Journal of Acquired Immune Deficiency Syndromes 26:5, 466-472
CrossRef174
Mario U Mondelli. (2001) Neonatal blood microtransfusions and hepatitis C virus infection. The Lancet 357:9265, 1363
CrossRef175
Antje Knöll, Magdalena Helmig, Ove Peters, Wolfgang Jilg. (2001) Hepatitis C Virus Transmission in a Pediatric Oncology Ward: Analysis of an Outbreak and Review of the Literature. Laboratory Investigation 81:3, 251-262
CrossRef176
Jae Sung Ko, Yon Ho Choe, Eun Joo Kim, Eun Hee Lee, Ja-June Jang, Jeong Kee Seo. (2001) Interferon-α Treatment of Chronic Hepatitis C in Children with Hemophilia. Journal of Pediatric Gastroenterology and Nutrition 32:1, 41-44
CrossRef177
G.W. McCaughan, A. Zekry. (2000) Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection. Transplant Infectious Disease 2:4, 166-185
CrossRef178
Delia Menozzi, Troy Udulutch, Augusto E. Llosa, Susan A. Galel. (2000) HCV lookback in the United States:effectiveness of an extended lookback program. Transfusion 40:11, 1393-1398
CrossRef179
Leonard B. Seeff. (2000) Why is there such difficulty in defining the natural history of hepatitis C?. Transfusion 40:10, 1161-1164
CrossRef180
Damien Mallat, Eugene Schiff. (2000) Viral hepatitis. Current Opinion in Gastroenterology 16:3, 255-261
CrossRef181
Richard Thompson. (2000) Pediatric liver disease. Current Opinion in Gastroenterology 16:3, 271-274
CrossRef182
Jay H. Lefkowitch. (2000) Pathology of the liver. Current Opinion in Gastroenterology 16:3, 200-207
CrossRef183
Mei-Hwei Chang. (2000) Treatment of chronic hepatitis C virus infection in children. Best Practice & Research Clinical Gastroenterology 14:2, 341-350
CrossRef184
(2000) Hepatitis C in Children. New England Journal of Medicine 342:4, 290-292
Full Text185
Jonas, Maureen M., . (1999) Hepatitis C Infection in Children. New England Journal of Medicine 341:12, 912-913
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