Original Article
Effect of Matching of Class I HLA Alleles on Clinical Outcome after Transplantation of Hematopoietic Stem Cells from an Unrelated Donor
N Engl J Med 1998; 339:1177-1185October 22, 1998
- Abstract
Background
The requirements with respect to HLA compatibility and the relative importance of matching for individual class I and class II HLA alleles in the transplantation of hematopoietic stem cells from unrelated donors have not yet been established.
Methods
We performed retrospective DNA typing of alleles at 11 polymorphic loci of HLA genes in 440 recipients of hematopoietic stem cells from unrelated donors who were serologically identical with their respective recipients for HLA-A, B, and DR antigens. Of these recipients, 80 percent had leukemia; the rest had lymphoma, marrow failure, or a congenital disorder.
Results
Multivariate analysis showed that incompatibility for HLA-A alleles and incompatibility for HLA-C alleles were independent risk factors for severe acute graft-versus-host disease (GVHD) (HLA-A, P=0.006; HLA-C, P=0.001). Mismatching of HLA-A, but not of HLA-C, alleles was an independent risk factor for death (P<0.001). Mismatching of HLA-C alleles was a significant risk factor for relapse of leukemia (P=0.035). HLA-B disparity was a significant risk factor for both GVHD and death in the univariate analysis, but not in the multivariate analysis. Disparities in class II HLA alleles of the DRB1, DQA1, DQB1, DPA1, and DPB1 loci were not identified as significant risk factors for acute GVHD or death in the multivariate analysis.
Conclusions
Genomic typing of class I HLA alleles adds substantially to the success of transplantation of hematopoietic stem cells from unrelated donors, even if the donors are serologically identical to their recipients with respect to HLA-A, B, and DR antigens.
Media in This Article
Figure 2
Kaplan–Meier Curves for the Probability of Survival.Figure 1
Kaplan–Meier Curves for the Cumulative Probability of Grade III or IV Acute GVHD.Article Activity
- Article
Patients with malignant hematologic diseases, various forms of marrow failure, and certain congenital disorders can be successfully treated with transplantation of hematopoietic stem cells from HLA-identical siblings.1-7 However, only 30 percent of patients for whom such treatment is the first choice have an HLA-matched donor within their immediate families. In studies in the United States of transplantation of marrow from unrelated donors, a single mismatch for HLA-A or B (class I HLA antigens) or HLA-DR (a class II HLA antigen), determined by serologic typing, increased the risk of acute graft-versus-host disease (GVHD) and decreased overall survival.8-10 Thus, in Japan, Europe,11 and the United States,12,13 transplantation of cells from unrelated donors is usually performed with donor–recipient pairs that are serologically identical for HLA-A, B, and DR antigens.
The multigene HLA family has at least 12 polymorphic loci: HLA-A, B, C, DRA1, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1. There is strong linkage disequilibrium among the alleles of HLA loci. DNA-amplification methods for typing class I and II HLA alleles have substantiated the extensive polymorphism of the HLA system,14 initially documented in serologic studies, and have defined alleles that cannot be identified serologically.15-24 Using these molecular techniques, several groups found that matching of DRB1 and DQB1 alleles, but not DPB1 alleles, decreased the risk of acute GVHD and improved survival after the transplantation of hematopoietic stem cells from unrelated donors who were serologically matched with the recipients for HLA-A, B, and DR antigens.25-29 The influence of class I HLA alleles was not evaluated in these investigations.
In the present study of stem-cell transplantation in Japan, we performed retrospective DNA typing at 11 polymorphic HLA loci, including class I HLA alleles, in 440 cases of transplantation from unrelated donors who were serologically identical to the recipients with respect to HLA-A, B, and DR antigens. The results showed that genomic matching of class I HLA alleles is an important factor in the clinical outcome of hematopoietic stem-cell transplantation.
Methods
HLA Typing
Serologic Assays
Serologic typing for HLA-A, B, and DR was performed with use of the standard two-stage complement-dependent test of microtoxicity.30
DNA Amplification
Alleles at the HLA-A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 loci were identified with the use of the polymerase chain reaction (PCR) with sequence-specific oligonucleotide probes,15-20 PCR restriction-fragment–length polymorphisms,21,22 PCR single-strand conformation polymorphisms,19,23 or PCR sequence-specific primers.24 To verify the reliability of the DNA-based results, we performed HLA genotyping of each sample in two to four laboratories, and resolved by consensus any discrepancies. These HLA-typing results were included in the statistical analyses.
Patients
A total of 440 donor–recipient pairs who were matched serologically for HLA-A, B, and DR antigens participated in this study. Four patients who survived fewer than 10 days after transplantation were excluded from the analysis of acute GVHD. The characteristics of the 440 donor–recipient pairs are summarized in Table 1Table 1
Base-Line Characteristics of the Donors and Recipients..HLA Typing of Patients and Donors
The patients were divided into four groups on the basis of the completeness of HLA genotyping (Table 1). Alleles at 11 polymorphic loci, HLA-A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1, were investigated for 363 donor–recipient pairs. HLA-C typing of 84 of the 363 pairs by means of PCR amplification of DNA with the sequence-specific primer could not be achieved. Accordingly, the first 363 pairs were divided into group 1 (279 pairs with HLA-C typing) and group 2 (84 pairs without HLA-C typing). From the analysis of this first set (groups 1 and 2), it was apparent that matching for alleles at HLA-DRB3, DRB4, DRB5, DQA1, DPA1, and DPB1 did not affect the risk of GVHD or survival; therefore, alleles at HLA-A, B, C, DRB1, and DQB1 were examined in the remaining 77 donor–recipient pairs. Information on HLA-C was obtained for 63 pairs but not for the other 14 pairs; thus, group 3 consisted of 63 pairs with HLA-C typing and group 4 of 14 pairs without HLA-C typing.
There were no significant differences among these groups in the base-line characteristics of the donor–recipient pairs (Table 1). Therefore, all the pairs were included in the univariate analysis of the effect of allele matching at the HLA-A, B, DRB1, and DQB1 loci. Groups 1 and 2 were included in the univariate analysis of the effect of allele matching at the HLA-DRB3, DRB4, DRB5, DQA1, DPA1, and DPB1 loci, and groups 1 and 3 were included in the univariate analysis of the effect of allele matching at the HLA-C locus and in the multivariate analysis.
Definition of HLA Mismatching
For each donor–recipient pair we determined whether the mismatch was one in which the recipient's alleles were not shared by the donor (defined as the GVHD vector) or the donor's alleles were not shared by the recipient (defined as the rejection vector). In the analysis of factors contributing to acute GVHD, the GVHD-vector mismatch was used. In the analyses of factors contributing to relapse or death, the mismatch was defined as that of either the GVHD vector or the rejection vector.
Evaluation of GVHD
Occurrences of acute GVHD were graded according to established criteria.31,32 The grades were 0, I, II, III and IV, according to the severity of GVHD in the skin, liver, and gastrointestinal tract.
Statistical Analysis
The estimated probability of the development of grade III or IV acute GVHD, the survival rate, and the relapse rate were calculated by the Kaplan–Meier method.33 The Mantel–Cox test was used to test the equality of cumulative curves for the incidence of grade III or IV GVHD, survival curves, and relapse curves.34 The Cox proportional-hazards model35 was used for multivariate adjustment of various covariates and for quantifying the relations among acute GVHD, death, relapse, and a group of explanatory variables (sex [donor–recipient pair], age of the recipient, age of the donor, diagnosis, leukemia risk group, and treatment) (Table 1). Selection of the factors with an important effect on the rates of acute GVHD, relapse, and survival was based on a forward stepwise procedure.36 P values of 0.05 or less were considered to indicate statistical significance. All statistical analyses were performed with BMDP statistical software (programs 1L, 2L, and 4F).36
Results
Compatibility of HLA Alleles
Among the 440 donor–recipient pairs that were serologically matched for HLA-A, B, and DR antigens, matching with respect to HLA-A, B, DRB1, and DQB1 alleles was found by DNA typing in 73 percent, 84 percent, 82 percent, and 80 percent of the pairs, respectively (Table 2Table 2
Extent of Matching of HLA Alleles among Donor–Recipient Pairs.). Of these 440 serologically matched pairs, 241 (55 percent) had identical HLA-A, B, and DRB1 alleles. We did not assess matching of HLA-C, DQ, and DP by serologic methods, but we noted in DNA typing that more than 69 percent of the pairs were compatible for alleles at the HLA-C, DQA1, and DQB1 loci. In contrast, fewer than 50 percent of the pairs were compatible with respect to DPA1 and DPB1 alleles.Acute GVHD
The incidence of acute GVHD of grade III or IV in our study was 18 percent (80 of 436 donor–recipient pairs). In the univariate analysis, no statistically significant associations were observed between the development of grade III or IV acute GVHD and sex (P=0.89), the age of the recipient at the time of transplantation (P=0.84), or the severity of disease (P=0.28).
The occurrence of grade III or IV acute GVHD was significantly associated with disparity in HLA-A, B and C alleles. For HLA-A alleles, the estimated cumulative rate of grade III or IV acute GVHD was 15 percent of the recipients in matched pairs, as compared with 31 percent of mismatched pairs (P<0.001) (Figure 1AFigure 1
Kaplan–Meier Curves for the Cumulative Probability of Grade III or IV Acute GVHD.). The corresponding rates for HLA-B were 17 percent and 31 percent (P=0.006), and for HLA-C, 13 percent and 32 percent (P<0.001) (Figure 1B and Figure 1C). In contrast, matching of DRB1, DQA1, and DQB1 alleles had no significant effect on the occurrence of severe acute GVHD. For DRB1 alleles the rates were 17 percent for matched pairs and 27 percent for mismatched pairs (P=0.058); the rates for DQA1 were 17 percent and 28 percent (P=0.14); and for DQB1 they were 18 percent and 22 percent (P=0.46). The probability that grade III or IV acute GVHD would develop in the recipients in DPA1- and DPB1-matched pairs (19 percent and 18 percent, respectively) and mismatched pairs (18 percent and 19 percent, respectively) were almost the same. The probability of grade III or IV acute GVHD among the 160 patients who received hematopoietic stem cells from unrelated donors with whom they were fully matched for HLA-A, B, C, and DRB1 at the allelic level was 11 percent, whereas in a previous study of 120 patients receiving transplants from genotypically identical siblings (matched for HLA-A, B, and DR) it was 6 percent.37 Multivariate analysis revealed that mismatches of the HLA-A allele and the HLA-C allele were significant risk factors for the development of grade III or IV acute GVHD (Table 3Table 3
Factors Affecting the Incidence of Grade III or IV Acute GVHD, Mortality, and Relapse in Recipients of Transplants from Unrelated Donors Who Were Serologically Matched for HLA-A, B, and DR.). Multivariate estimates of the odds ratios for grade III or IV acute GVHD in pairs matched for the HLA-A alleles or HLA-C alleles were 0.48 (P=0.006) and 0.42 (P=0.001), respectively, as compared with those with mismatches (Table 3). Matching of the HLA-B allele was not a significant factor in the development of acute GVHD (P=0.22). When the HLA-A,C–matched donor–recipient pairs were evaluated for the occurrence of grade III or IV acute GVHD, the probability of its occurrence in 8 pairs mismatched at HLA-B (25 percent) was higher than that in 178 pairs matched at HLA-B (11 percent), although the difference was not statistically significant (P=0.18).The probability that the recipient in a pair mismatched at the HLA-A, B, or C locus would have grade III or IV acute GVHD was 20 percent when there was one mismatch and 43 percent when there were two or more mismatches, as compared with 11 percent when there were no mismatches (P<0.001).
Survival
As shown in Figure 2AFigure 2
Kaplan–Meier Curves for the Probability of Survival., matching of the HLA-A allele was associated with increased survival (survival rate at one year, 63 percent among matched and 38 percent among mismatched recipients; P<0.001). There was a weak association between HLA-B matching and an increased rate of survival (survival rate at one year, 58 percent among matched and 44 percent among mismatched pairs; P=0.039) (Figure 2B). Even in HLA-A–matched pairs, HLA-B matching was associated with an increased rate of survival among recipients (survival rate at one year, 65 percent among matched and 49 percent among mismatched pairs; P=0.045) (Figure 2D). Surprisingly, HLA-C matching was not associated with increased survival (survival rate at one year, 57 percent among matched and 53 percent among mismatched pairs; P=0.69), even though mismatching at HLA-C was found to be an important risk factor for acute GVHD (Figure 2C). Survival rates at one year among recipients matched for the HLA-DRB1, DQA1, and DQB1 alleles were 59 percent, 58 percent, and 59 percent, respectively, as compared with 45 percent, 41 percent, and 42 percent among mismatched recipients (P=0.023, P=0.077, and P=0.016, respectively).To test whether the effects of class II HLA matching on survival are due to linkage disequilibrium within the HLA system, we analyzed the effect of matching for class II HLA alleles on the survival rate in the 276 patients matched with their donors for both the HLA-A and the HLA-B allele. In this group, matching or mismatching of the HLA-DRB1, DQA1, or DQB1 alleles had no influence on survival (P=0.44, P=0.35, and P=0.080, respectively) (Figure 2E and Figure 2F). The survival curves for patients matched for HLA-DPA1 and DPB1 alleles among 203 patients who were also matched for HLA-A, B, DRB1, DRB3, DRB4, and DRB5 alleles did not differ significantly (survival rates at one year, 55 percent and 57 percent, respectively) from the survival curves of DPA1- and DPB1-mismatched patients (survival rates at one year, 57 percent and 55 percent, respectively). The survival rate at one year among the 157 patients who received hematopoietic stem cells from unrelated donors fully matched at HLA-A, B, C, and DRB1 alleles was 65 percent.
Survival was also related to the recipient's age (survival rates at one year, 62 percent for recipients younger than 18 years, 58 percent for recipients 18 to 35 years old, and 41 percent for those older than 35 years; P=0.003) and to the leukemia risk group (survival at one year, 65 percent for those at standard risk and 46 percent for those at high risk; P<0.001), but it was not associated with sex (P=0.85).
Multivariate analysis identified four factors — namely, HLA-A matching, the recipient's age, the leukemia risk group, and diagnosis — as important independent factors affecting mortality among patients receiving hematopoietic stem cells from unrelated donors. Multivariate estimates of the odds ratios for death in recipients with an HLA-A–allele match, an age greater than 40 years, a high risk of leukemia, and a diagnosis of acute myeloid leukemia were 0.45 (P<0.001), 2.33 (P<0.001), 1.69 (P<0.001), and 0.63 (P=0.042), respectively, as compared with recipients without these factors (Table 3).
Relapse of Leukemia
By univariate analysis, the rate of relapse of leukemia in the HLA-C–matched group was higher than that in the HLA-C–mismatched group, although this difference did not reach statistical significance (relapse rate at one year, 23 percent for the matched group and 12 percent for the mismatched group; P=0.060) (Figure 3Figure 3
Kaplan–Meier Curves for the Probability of Relapse of Leukemia.). Matches for HLA-A, B (Figure 3), DRB1, DQA1, DQB1, DPA1, or DPB1 (data not shown) had no influence on the rate of leukemic relapse. Multivariate estimates of the odds ratios for relapse associated with a high risk of leukemia and an HLA-C match were 3.23 (P<0.001) and 2.22 (P=0.035), respectively (Table 3), suggesting that HLA-C matching is a risk factor for leukemic relapse. The relapse rate at one year for the 141 patients who received hematopoietic stem cells from an unrelated donor who was fully matched at the allelic level for HLA-A, B, C, and DRB1 was 20 percent.Discussion
Our results show that mismatches with respect to HLA-A and HLA-C alleles between the donor and recipient of hematopoietic stem cells are strong risk factors for the development of grade III or IV acute GVHD in the recipient. By contrast, incompatibilities for class II HLA alleles did not have a critical effect on the risk of acute GVHD. Previous investigations demonstrated that matching of the HLA-DRB1 and DQB1 alleles affects the development of acute GVHD,27,28 but the effects of matching of the HLA-A, B, and C alleles were not examined in those studies. Therefore, it is possible that the finding of an association between an increased risk of GVHD and mismatches of alleles at the DRB1 and DQB1 loci actually reflected class I HLA disparities, because of the strong linkage disequilibrium between class I and class II HLA alleles. Alternatively, it is possible that the roles of the individual HLA loci in hematopoietic stem-cell transplantation differ according to ethnic background. Mismatching at the HLA-A locus was observed most frequently for A2 among our Japanese donor–recipient pairs (96 of 190 Japanese patients [51 percent]) whereas in most whites the HLA-A2 allele is A*0201.38 Thus, mismatching for HLA-A2 alleles may be less frequent in white than in Japanese populations.
Previous studies demonstrated that the occurrence of GVHD correlates with a decreased risk of relapse of leukemia after hematopoietic stem-cell transplantation, probably because of T cells or natural killer cells in the graft that are cytotoxic to leukemic cells (a graft-versus-leukemia mechanism).39-41 The association we observed between matching of the HLA-C allele and an increased risk of leukemic relapse suggests that the use of stem cells that are mismatched at the HLA-C locus can avert relapse, possibly by inducing a graft-versus-leukemia reaction. Studies of killer-cell inhibitory receptors on natural killer cells and some CD8+ cytotoxic T lymphocytes have shown that specific recognition of HLA-C molecules on target cells by these inhibitory receptors inhibits the lytic activity of the natural killer cells and cytotoxic T cells.42-44 Therefore, in principle, a mismatch at HLA-C would allow engrafted natural killer cells and cytotoxic T cells to lyse the recipient's leukemic cells without the usual inhibition.
The overall rate of survival was significantly affected by HLA-A mismatching, which agrees with our finding that HLA-A mismatching is a strong risk factor for acute GVHD. By contrast, the overall survival rate was not affected by HLA-C incompatibility, even though HLA-C disparity is a strong risk factor for grades III and IV acute GVHD. This discrepancy may be due to the protection from leukemic relapse that is apparently provided by an HLA-C mismatch.
In a univariate analysis, there was a significant difference in the frequency of acute GVHD between HLA-B–matched and HLA-B–mismatched pairs (P=0.006) and a lower rate of survival among HLA-B–mismatched patients, even in the HLA-A–matched group (P=0.045). However, in a multivariate analysis we did not find that mismatching for HLA-B alleles was a significant risk factor for acute GVHD and death from any cause. This difference may reflect the relatively small number of allele mismatches at the HLA-B locus, as compared with those at the HLA-A and C loci. For this reason, we believe that HLA-B disparity should not be disregarded as a factor affecting both the risk of GVHD and overall survival.
As for the HLA-DRB1 and DQB1 loci, we found a slightly lower rate of survival in the mismatched group than in the matched group when results in HLA-A–matched and HLA-B–matched patients were evaluated, but the difference did not reach statistical significance. Further investigation is needed to determine the effect of the matching of HLA-DRB1 and DQB1 alleles on survival.
It is very difficult to match HLA-DP alleles together with HLA-A and B alleles because of the lack of strong linkage disequilibrium between these alleles. Therefore, it is fortunate that disparity of HLA-DP had no important effects on the clinical outcome of recipients of hematopoietic stem cells from unrelated donors.
In conclusion, our new, clinically relevant observations are that HLA-A and C disparities at the allelic level are important risk factors for severe acute GVHD; that HLA-A disparity is an important risk factor for death from all causes; that HLA-C matching at the allelic level is a risk factor for relapse of leukemia; and that HLA-B matching at the allelic level is also probably a risk factor both for severe acute GVHD and for death from all causes.
Supported by research funds for bone marrow transplantation from the Ministry of Health and Welfare of Japan.
Source Information
From the Department of Genetics, Medical Institute of Bioregulation (T.S., N. Kamikawaji), and the Department of Medical Informatics, Faculty of Medicine (N. Kinukawa), Kyushu University, Fukuoka; the Japanese Red Cross Central Blood Center, Tokyo (T.J., T.A.); the Department of Hematology and Chemotherapy, Aichi Cancer Center Hospital, Nagoya (Y.M.); the Department of Surgery, Sakura National Hospital, Chiba (H.K.); the Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Kanagawa (H.I.); the Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo (T.Y.); the Department of Tissue Physiology, Division of Adult Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo (A.K.); the Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital, Nagoya (Y.K.); and Jichi Medical School, Tochigi (F.T.) — all in Japan.
Address reprint requests to Dr. Sasazuki at the Department of Genetics, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Other participants in the Japan Marrow Donor Program are listed in the Appendix.
Other authors were Yoshiaki Nose, M.D., Ph.D. (Department of Medical Informatics, Faculty of Medicine, Kyushu University), Takashi Ono, M.D. (Department of Genetics, Medical Institute of Bioregulation, Kyushu University), Takeo Sakamaki, M.D., Ph.D. (Division of Clinical Research, Sakura National Hospital), Shunichi Kato, M.D., Ph.D. (Department of Pediatrics, Tokai University School of Medicine), Yuichi Akiyama, M.D. (Department of Pediatrics, Kyoto University School of Medicine, Kyoto), Shinichiro Okamoto, M.D., Ph.D. (Department of Medicine, Keio University School of Medicine, Tokyo), Hiroo Dohy, M.D., Ph.D. (Department of Medicine, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima), Mine Harada, M.D., Ph.D. (Second Department of Internal Medicine, Okayama University School of Medicine, Okayama), and Shigetaka Asano, M.D., Ph.D. (Institute of Medical Science, Tokyo University, Tokyo).
Appendix
The following centers and investigators, all in Japan, participated in the study: Kyushu University — S. Yasunaga, S. Yoshitake, T. Koyanagi; Tokyo Medical and Dental University — Y. Date; Japanese Red Cross Central Blood Center — Y. Ishikawa, K. Sawanaka, K. Kashiwase, A. Ogawa; Tokai University School of Medicine — T. Naruse, H. Ando, Y. Matsuzawa; Chugai Diagnostics Science — K. Matsubara, A. Kobayashi; Transplantation centers — Hokkaido University Hospital, Sapporo University Hospital, Sapporo Hokuyu Hospital, Japanese Red Cross Asahikawa Hospital, Hirosaki University Hospital, Tohoku University Hospital, Yamagata University Hospital, Akita University Hospital, Fukushima Medical College, National Cancer Center Central Hospital, Institute of Medical Science at the University of Tokyo, Toho University Hospital, Omori Hospital, Tokyo Metropolitan Komagome Hospital, Nihon University Hospital, Itabashi Hospital, Jikei University Hospital, Keio University Hospital, Tokyo Medical College Hospital, Tokyo Medical and Dental University Hospital Faculty of Medicine, Yokohama City University Hospital, Kanagawa Children's Medical Center, Kanagawa Cancer Center, Tokai University Hospital, St. Marianna University Hospital, Chiba Children's Hospital, Matsudo Municipal Hospital, Kameda General Hospital, Saitama Children's Medical Center, Saitama Cancer Center Hospital, Saitama Medical School Hospital, Ibaraki Children's Hospital, Jichi Medical School Hospital, Dokkyo University Hospital, Fukaya Red Cross Hospital, Saiseikai Maebashi Hospital, Gunma University School of Medicine, Niigata University Hospital, Niigata Cancer Center Hospital, Shinshu University Hospital, Saku Central Hospital, Hamamatsu University Hospital, Hamamatsu Medical Center, Shizuoka General Hospital, Shizuoka Children's Hospital, Japanese Red Cross Nagoya First Hospital, Nagoya Daini Red Cross Hospital, Meitetsu Hospital, Nagoya University Hospital, Nagoya Ekisaikai Hospital, National Nagoya Hospital, Aichi Medical School Hospital, Nagoya City University Hospital, Showa Hospital, Anjo Kousei Hospital, Fujita Health University Hospital, Mie University Hospital, Kanazawa University Hospital, Kanazawa Medical University Hospital, Toyama Prefectural Central Hospital, Fukui Medical School Hospital, Shiga University of Medical Science, Center for Adult Disease in Osaka, Kinki University Hospital, Osaka University Hospital, Osaka Medical Center and Research Institute for Maternal and Child Health, Matsushita Memorial Hospital, Hyogo College of Medicine Hospital, Hyogo Medical Center for Adults, Kobe City General Hospital, Kobe University Hospital, Kyoto University Hospital, Kyoto Prefectural University of Medicine Hospital, Social Insurance Kyoto Hospital, Tottori Prefectural Central Hospital, Tottori University Hospital, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Yamaguchi University Hospital, Ehime Prefectural Central Hospital, Okayama National Hospital, Kurashiki Central Hospital, Kyushu University Hospital, Harasanshin General Hospital, Hamanomachi General Hospital, National Kyushu Cancer Center, St. Mary's Hospital, Kokura Memorial Hospital, Saga Prefectural Hospital, Nagasaki University Hospital, Miyazaki Prefectural Hospital, Kumamoto National Hospital, Kumamoto University Hospital, Oita Medical University Hospital, and Kagoshima University Hospital.
- References
References
1
Thomas ED . Marrow transplantation for malignant diseases. J Clin Oncol 1983;1:517-531
Web of Science | Medline2
O'Reilly RJ . Allogenic bone marrow transplantation: current status and future directions. Blood 1983;62:941-964
Web of Science | Medline3
Champlin RE ,Gale RP . Role of bone marrow transplantation in the treatment of hematologic malignancies and solid tumors: critical review of syngeneic, autologous, and allogeneic transplants. Cancer Treat Rep 1984;68:145-161
Medline4
Bortin MM ,Horowitz MM ,Gale RP , et al. Changing trends in allogeneic bone marrow transplantation for leukemia in the 1980s. JAMA 1992;268:607-612
CrossRef | Web of Science | Medline5
Hirabayashi N ,Kodera Y ,Matsuyama T , et al. Bone marrow transplantation in 614 patients: twenty year experience of the Nagoya Bone Marrow Transplantation Group (NBMTG). Transplant Proc 1995;27:1380-1382
Web of Science | Medline6
Hansen JA ,Petersdorf E ,Martin PJ ,Anasetti C . Hematopoietic stem cell transplants from unrelated donors. Immunol Rev 1997;157:141-151
CrossRef | Web of Science | Medline7
Dupont B . Immunology of hematopoietic stem cell transplantation: a brief review of its history. Immunol Rev 1997;157:5-12
CrossRef | Web of Science | Medline8
Beatty PG ,Anasetti C ,Hansen JA , et al. Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus. Blood 1993;81:249-253
Web of Science | Medline9
Davies SM ,Shu XO ,Blazar BR , et al. Unrelated donor bone marrow transplantation: influence of HLA A and B incompatibility on outcome. Blood 1995;86:1636-1642
Web of Science | Medline10
Spencer AP ,Brookes PA ,Kaminski E , et al. Cytotoxic T lymphocyte precursor frequency analyses in bone marrow transplantation with volunteer unrelated donors: value in donor selection. Transplantation 1995;59:1302-1308
Web of Science | Medline11
Hows JM ,Yin JL ,Marsh J , et al. Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia. Blood 1986;68:1322-1328
Web of Science | Medline12
McCullough J ,Rogers G ,Dahl R , et al. Development and operation of a program to obtain volunteer bone marrow donors unrelated to the patient. Transfusion 1986;26:315-323
CrossRef | Web of Science | Medline13
McElligott MC ,Menitove JE ,Aster RH . Recruitment of unrelated persons as bone marrow donors: a preliminary experience. Transfusion 1986;26:309-314
CrossRef | Web of Science | Medline14
Bodmer JG ,Marsh SG ,Albert ED , et al. Nomenclature for factors of the HLA system, 1996. Tissue Antigens 1997;49:297-321
CrossRef | Web of Science | Medline15
Kimura A ,Dong RP ,Harada H ,Sasazuki T . DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA. Tissue Antigens 1992;40:5-12
CrossRef | Web of Science | Medline16
Kimura A, Sasazuki T. Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique. In: Tsuji K, Aizawa M, Sasazuki T, eds. HLA 1991: proceedings of the Eleventh International Histocompatibility Workshop and Conference. Vol. 1. Oxford, England: Oxford University Press, 1992:397-419.
17
Date Y ,Kimura A ,Kato H ,Sasazuki T . DNA typing of HLA-A gene: population study and identification of four new alleles in Japanese. Tissue Antigens 1996;47:93-101
CrossRef | Web of Science | Medline18
Yasunaga S ,Kimura A ,Hamaguchi K ,Ronningen KS ,Sasazuki T . Different contribution of HLA-DR and DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). Tissue Antigens 1996;47:37-48
CrossRef | Web of Science | Medline19
Tokunaga K ,Ishikawa Y ,Ogawa A , et al. Sequence-based association analysis of HLA class I and II alleles in Japanese supports conservation of common haplotypes. Immunogenetics 1997;46:199-205
CrossRef | Web of Science | Medline20
Matsubara K ,Koide Y ,Kobayashi A , et al. A rapid and sensitive method of HLA-DRB1 typing by acridinium-ester-labeled DNA probes. Hum Immunol 1992;35:132-139
CrossRef | Web of Science | Medline21
Inoko H, Ota M. PCR-RFLP. In: Hui KM, Bidwell JL, eds. Handbook of HLA typing techniques. Boca Raton, Fla.: CRC Press, 1993:9-70.
22
Naruse TK ,Ando R ,Nose Y , et al. HLA-DRB4 genotyping by PCR-RFLP: diversity in the associations between HLA-DRB4 and DRB1 alleles. Tissue Antigens 1997;49:152-159
CrossRef | Web of Science | Medline23
Kimura A, Hoshino S, Yoshida M, Harada H, Sasazuki T. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of HLA genes: a practical HLA-matching system. In: Tsuji K, Aizawa M, Sasazuki T, eds. HLA 1991: proceedings of the Eleventh International Histocompatibility Workshop and Conference. Vol. 1. Oxford, England: Oxford University Press, 1992:511-4.
24
Ando H ,Mizuki N ,Ando R , et al. HLA-C genotyping in the Japanese population by the PCR-SSP method. Tissue Antigens 1996;48:55-58
CrossRef | Web of Science | Medline25
Speiser DE ,Tiercy JM ,Rufer N , et al. High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation. Blood 1996;87:4455-4462
Web of Science | Medline26
Santamaria P ,Reinsmoen NL ,Lindstrom AL , et al. Frequent HLA class I and DP sequence mismatches in serologically (HLA-A, HLA-B, HLA-DR) and molecularly (HLA-DRB1, HLA-DQA1, HLA-DQB1) HLA-identical unrelated bone marrow transplant pairs. Blood 1994;83:280-287[Erratum, Blood 1994;83:3834.]
Web of Science | Medline27
Petersdorf EW ,Longton GM ,Anasetti C , et al. Definition of HLA-DQ as a transplantation antigen. Proc Natl Acad Sci U S A 1996;93:15358-15363
CrossRef | Web of Science | Medline28
Petersdorf EW ,Longton GM ,Anasetti C , et al. The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood 1995;86:1606-1613
Web of Science | Medline29
Petersdorf EW ,Smith AG ,Mickelson EM , et al. The role of HLA-DPB1 disparity in the development of acute graft-versus-host disease following unrelated donor marrow transplantation. Blood 1993;81:1923-1932
Web of Science | Medline30
Terasaki PI ,McClelland JD . Microdroplet assay of human serum cytotoxins. Nature 1964;204:998-1000
CrossRef | Web of Science | Medline31
Glucksberg H ,Storb R ,Fefer A , et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 1974;18:295-304
CrossRef | Web of Science | Medline32
Kernan NA ,Bartsch G ,Ash RC , et al. Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med 1993;328:593-602
Full Text | Web of Science | Medline33
Kaplan EL ,Meier P . Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481
CrossRef | Web of Science34
Mantel N . Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-170
Medline35
Cox DR . Regression models and life-tables. J R Stat Soc [B] 1972;34:187-22036
Dixon WJ, ed. BMDP statistical software manual. 3rd ed. Berkeley: University of California Press, 1992.
37
Morishima Y ,Morishita Y ,Tanimoto M , et al. Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings: possible role of genetic homogeneity. Blood 1989;74:2252-2256
Web of Science | Medline38
Fleischhauer K ,Zino E ,Mazzi B ,Severini GM ,Benazzi E ,Bordignon C . HLA-A02 subtype distribution in Caucasians from northern Italy: identification of A0220. Tissue Antigens 1996;48:673-679[Erratum, Tissue Antigens 1997;50:208.]
CrossRef | Web of Science | Medline39
Weiden PL ,Flournoy N ,Thomas ED , et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med 1979;300:1068-1073
Full Text | Web of Science | Medline40
Horowitz MM ,Gale RP ,Sondel PM , et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990;75:555-562
Web of Science | Medline41
Hauch M ,Gazzola MV ,Small T , et al. Anti-leukemia potential of interleukin-2 activated natural killer cells after bone marrow transplantation for chronic myelogenous leukemia. Blood 1990;75:2250-2262
Web of Science | Medline42
Moretta A ,Biassoni R ,Bottino C , et al. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 1997;155:105-117
CrossRef | Web of Science | Medline43
Reyburn H ,Mandelboim O ,Vales-Gomez M , et al. Human NK cells: their ligands, receptors and functions. Immunol Rev 1997;155:119-125
CrossRef | Web of Science | Medline44
Moretta A ,Moretta L . HLA class I specific inhibitory receptors. Curr Opin Immunol 1997;9:694-701
CrossRef | Web of Science | Medline
- Citing Articles (197)
Citing Articles
1
S Yoshihara, K Taniguchi, H Ogawa, H Saji. (2012) The role of HLA antibodies in allogeneic SCT: is the ‘type-and-screen’ strategy necessary not only for blood type but also for HLA?. Bone Marrow Transplantation
CrossRef2
Béatrice Pédron, Valérie Guérin-El Khourouj, Jean-Hugues Dalle, Marie Ouachée-Chardin, Karima Yakouben, France Corroyez, Anne Auvrignon, Arnaud Petit, Judith Landman-Parker, Guy Leverger, André Baruchel, Ghislaine Sterkers. (2011) Contribution of HLA-A/B/C/DRB1/DQB1 Common Haplotypes to Donor Search Outcome in Unrelated Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 17:11, 1612-1618
CrossRef3
J L Espinoza, A Takami, M Onizuka, T Kawase, H Sao, H Akiyama, K Miyamura, S Okamoto, M Inoue, S Ohtake, T Fukuda, Y Morishima, Y Kodera, S Nakao. (2011) A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT. Bone Marrow Transplantation 46:11, 1455-1463
CrossRef4
Valerie Dubois, Catherine Giannoli, Marie Lorraine Balère, Sylvie Rey, Colette Raffoux, Dominique Rigal. (2011) Does high-resolution donor typing of HLA-C or other loci upon registration confer advantages to patients?. Human Immunology 72:11, 1033-1038
CrossRef5
S. O. Ciurea, P. F. Thall, X. Wang, S. A. Wang, Y. Hu, P. Cano, F. Aung, G. Rondon, J. J. Molldrem, M. Korbling, E. J. Shpall, M. de Lima, R. E. Champlin, M. Fernandez-Vina. (2011) Donor-specific anti-HLA antibodies and graft failure in matched unrelated donor hematopoietic stem cell transplantation. Blood
CrossRef6
T Lodewyck, M Oudshoorn, B van der Holt, E Petersen, E Spierings, P A von dem Borne, A Schattenberg, W Allebes, M Groenendijk-Sijnke, L Duinhouwer, R Willemze, B Lowenberg, L F Verdonck, E Meijer, J J Cornelissen. (2011) Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia. Leukemia 25:10, 1548-1554
CrossRef7
Yoshiko Atsuta, Yasuo Morishima, Ritsuro Suzuki, Tokiko Nagamura-Inoue, Shuichi Taniguchi, Satoshi Takahashi, Shunro Kai, Hisashi Sakamaki, Yasushi Kouzai, Naoki Kobayashi, Takahiro Fukuda, Hiroshi Azuma, Minoko Takanashi, Takehiko Mori, Masahiro Tsuchida, Takakazu Kawase, Keisei Kawa, Yoshihisa Kodera, Shunichi Kato. (2011) Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia. Biology of Blood and Marrow Transplantation
CrossRef8
Florence Bettens, Jakob Passweg, Urs Schanz, Yves Chalandon, Dominik Heim, Tayfun Güngör, Georg Stussi, Grazia Nicoloso, Helen Baldomero, Alois Gratwohl, Jean-Marie Tiercy. (2011) Impact of HLA-DPB1 Haplotypes on Outcome of 10/10 Matched Unrelated Hematopoietic Stem Cell Donor Transplants Depends on MHC-Linked Microsatellite Polymorphisms. Biology of Blood and Marrow Transplantation
CrossRef9
Ming-Rui Huo, Lan-Ping Xu, Li D, Dai-Hong Liu, Kai-Yan Liu, Huan Chen, Wei Han, Yu-Hong Chen, Wang Y, Jing-Zhi Wang, Xiao-Hui Zhang, Xiang-Yu Zhao, Xiao-Jun Huang. (2011) The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation. Clinical Transplantationno-no
CrossRef10
Y Inamoto, K Miyamura, S Okamoto, H Akiyama, H Iida, T Eto, Y Morishima, K Kawa, A Kikuchi, Y Nagatoshi, J Tanaka, T Ashida, M Hirokawa, M Tsuchida, S Mori. (2011) Disease stage stratified effects of cell dose in unrelated BMT for hematological malignancies: a report from Japan marrow donor program. Bone Marrow Transplantation 46:9, 1192-1202
CrossRef11
S Yoshihara, K Ikegame, K Kaida, K Taniguchi, R Kato, T Inoue, T Fujioka, H Tamaki, M Okada, T Soma, H Ogawa. (2011) Incidence of extramedullary relapse after haploidentical SCT for advanced AML/myelodysplastic syndrome. Bone Marrow Transplantation
CrossRef12
Y. Xu, Z. Deng, C. O'hUigin, D. Wang, S. Gao, J. Zeng, B. Yang, S. Jin, H. Zou. (2011) Characterization and polymorphic analysis of 4.5 kb genomic full-length HLA-C in the Chinese Han population. Tissue Antigens 78:2, 102-114
CrossRef13
F. Colucci, S. Boulenouar, J. Kieckbusch, A. Moffett. (2011) How does variability of immune system genes affect placentation?. Placenta 32:8, 539-545
CrossRef14
S. Terakura, Y. Atsuta, M. Sawa, H. Ohashi, T. Kato, S. Nishiwaki, N. Imahashi, T. Yasuda, M. Murata, K. Miyamura, R. Suzuki, T. Naoe, T. Ito, Y. Morishita, . (2011) A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hematopoietic malignancies. Annals of Oncology 22:8, 1865-1871
CrossRef15
Ulas D. Bayraktar, Richard E. Champlin, Stefan O. Ciurea. (2011) Progress in Haploidentical Stem Cell Transplantation. Biology of Blood and Marrow Transplantation
CrossRef16
M Takanashi, H Tanaka, M Kohsaki, K Nakajima, K Tadokoro, M Nakabayashi. (2011) A suggested total size for the cord blood banks of Japan. Bone Marrow Transplantation 46:7, 1014-1015
CrossRef17
Stefan O. Ciurea, Rima M. Saliba, Gabriela Rondon, Poliana A. Patah, Fleur Aung, Pedro Cano, Borje S. Andersson, Partow Kebriaei, Uday Popat, Marcelo Fernandez-Vina, Richard E. Champlin, Marcos de Lima. (2011) Outcomes of Patients with Myeloid Malignancies Treated with Allogeneic Hematopoietic Stem Cell Transplantation from Matched Unrelated Donors Compared with One Human Leukocyte Antigen Mismatched Related Donors Using HLA Typing at 10 Loci. Biology of Blood and Marrow Transplantation 17:6, 923-929
CrossRef18
Ann Woolfrey, John P. Klein, Michael Haagenson, Stephen Spellman, Effie Petersdorf, Machteld Oudshoorn, James Gajewski, Gregory A. Hale, John Horan, Minoo Battiwalla, Susana R. Marino, Michelle Setterholm, Olle Ringden, Carolyn Hurley, Neal Flomenberg, Claudio Anasetti, Marcelo Fernandez-Vina, Stephanie J. Lee. (2011) HLA-C Antigen Mismatch Is Associated with Worse Outcome in Unrelated Donor Peripheral Blood Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 17:6, 885-892
CrossRef19
Tsuyoshi Tanabe, Natsu Yamaguchi, Koichi Matsuda, Keiko Yamazaki, Satoshi Takahashi, Arinobu Tojo, Makoto Onizuka, Yoshinobu Eishi, Hideki Akiyama, Jun Ishikawa, Takehiko Mori, Masamichi Hara, Kazutoshi Koike, Keisei Kawa, Takakazu Kawase, Yasuo Morishima, Hiroki Amano, Mikiko Kobayashi-Miura, Takeyasu Kakamu, Yusuke Nakamura, Shigetaka Asano, Yasuyuki Fujita. (2011) Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population. International Journal of Hematology 93:6, 771-778
CrossRef20
Joseph Pidala, Claudio Anasetti. 2011. Advances in Allogeneic Hematopoietic Cell Transplantation: Progress in Transplantation Technology and Disease-Specific Outcomes. , 367-383.
CrossRef21
A Takami, J L Espinoza, M Onizuka, K Ishiyama, T Kawase, Y Kanda, H Sao, H Akiyama, K Miyamura, S Okamoto, M Inoue, S Ohtake, T Fukuda, Y Morishima, Y Kodera, S Nakao. (2011) A single-nucleotide polymorphism of the Fcγ receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies. Bone Marrow Transplantation 46:2, 238-243
CrossRef22
A. Balas, F. García-Sánchez, J. L. Vicario. (2011) Allelic and haplotypic HLA frequency distribution in Spanish hematopoietic patients. Implications for unrelated donor searching. Tissue Antigens 77:1, 45-53
CrossRef23
Ulas Darda Bayraktar, Marcos de Lima, Stefan Octavian Ciurea. (2011) Advances in haploidentical stem cell transplantation. Revista Brasileira de Hematologia e Hemoterapia 33:3, 237-241
CrossRef24
Takehiko Mori, Yoshinobu Aisa, Jun Kato, Akiko Yamane, Tomonori Nakazato, Noyuki Shigematsu, Shinichiro Okamoto. (2011) Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. American Journal of Hematologyn/a-n/a
CrossRef25
Sang-Hyun Hwang, Heung-Bum Oh, Sung-Eun Choi, Jong-Jin Seo, Jae-Hwan Lee, Sung-Woo Cho, Jeong-Min Chae, Yong-Seok Heo, Chulhun L. Chang, Eun-Yup Lee. (2010) Impact of amino acid substitution at residue 9 of HLA-A2 on the development of acute GVHD in Korean pediatric patients receiving unrelated hematopoietic stem cell transplantation. Transplant International 23:12, 1216-1222
CrossRef26
Maarten Naesens, Minnie M. Sarwal. (2010) Molecular diagnostics in transplantation. Nature Reviews Nephrology 6:10, 614-628
CrossRef27
M Michallet, M Sobh, D Milligan, S Morisset, D Niederwieser, V Koza, T Ruutu, N H Russell, L Verdonck, N Dhedin, A Vitek, M Boogaerts, L Vindelov, J Finke, V Dubois, A van Biezen, R Brand, T de Witte, P Dreger. (2010) The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL: a retrospective study from the EBMT registry. Leukemia 24:10, 1725-1731
CrossRef28
Leo Luznik, Ephraim J. Fuchs. (2010) High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation. Immunologic Research 47:1-3, 65-77
CrossRef29
S. Morishima, S. Ogawa, A. Matsubara, T. Kawase, Y. Nannya, K. Kashiwase, M. Satake, H. Saji, H. Inoko, S. Kato, Y. Kodera, T. Sasazuki, Y. Morishima, . (2010) Impact of highly conserved HLA haplotype on acute graft-versus-host disease. Blood 115:23, 4664-4670
CrossRef30
Koji Nagafuji, Keitaro Matsuo, Takanori Teshima, Shin-ichiro Mori, Hisashi Sakamaki, Michihiro Hidaka, Hiroyasu Ogawa, Yoshihisa Kodera, Yoshinobu Kanda, Atsuo Maruta, Takehiko Mori, Fumiaki Yoshiba, Tatsuo Ichinohe, Masanobu Kasai, Yoshifusa Takatsuka, Kohmei Kubo, Hiroshi Sao, Yoshiko Atsuta, Ritsuro Suzuki, Takashi Yoshida, Masahiro Tsuchida, Mine Harada. (2010) Peripheral blood stem cell versus bone marrow transplantation from HLA-identical sibling donors in patients with leukemia: a propensity score-based comparison from the Japan Society for Hematopoietic Stem Cell Transplantation registry. International Journal of Hematology 91:5, 855-864
CrossRef31
Katia Perruccio, Pierluigi Bonifazi, Fabiana Topini, Antonella Tosti, Silvia Bozza, Teresa Aloisi, Alessandra Carotti, Franco Aversa, Massimo F. Martelli, Luigina Romani, Andrea Velardi. (2010) Thymosin α1 to harness immunity to pathogens after haploidentical hematopoietic transplantation. Annals of the New York Academy of Sciences 1194:1, 153-161
CrossRef32
I. B. Villalobos, Y. Takahashi, Y. Akatsuka, H. Muramatsu, N. Nishio, A. Hama, H. Yagasaki, H. Saji, M. Kato, S. Ogawa, S. Kojima. (2010) Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation. Blood 115:15, 3158-3161
CrossRef33
Hirohisa Nakamae, Barry E. Storer, Rainer Storb, Jan Storek, Thomas R. Chauncey, Michael A. Pulsipher, Finn B. Petersen, James C. Wade, Michael B. Maris, Benedetto Bruno, Jens Panse, Effie Petersdorf, Ann Woolfrey, David G. Maloney, Brenda M. Sandmaier. (2010) Low-Dose Total Body Irradiation and Fludarabine Conditioning for HLA Class I-Mismatched Donor Stem Cell Transplantation and Immunologic Recovery in Patients with Hematologic Malignancies: A Multicenter Trial. Biology of Blood and Marrow Transplantation 16:3, 384-394
CrossRef34
Mun-Kit Choy, Maude E. Phipps. (2010) MICA polymorphism: biology and importance in immunity and disease. Trends in Molecular Medicine 16:3, 97-106
CrossRef35
K Kataoka, Y Nannya, K Ueda, K Kumano, T Takahashi, M Kurokawa. (2010) Differential prognostic impact of pretransplant comorbidity on transplant outcomes by disease status and time from transplant: a single Japanese transplant centre study. Bone Marrow Transplantation 45:3, 513-520
CrossRef36
Dennis L. Confer, Linda K. Abress, Willis Navarro, Alejandro Madrigal. (2010) Selection of Adult Unrelated Hematopoietic Stem Cell Donors: Beyond HLA. Biology of Blood and Marrow Transplantation 16:1, S8-S11
CrossRef37
KAZUEI OGAWA, HIDEYOSHI NOJI, MIKI FURUKAWA, KAYO HARADA-SHIRADO, YUMIKO MASHIMO, HIROSHI TAKAHASHI, HAYATO MATSUMOTO, SATOSHI KIMURA, AKIKO SHICHISHIMA-NAKAMURA, HIROSHI OHKAWARA, KAZUHIKO IKEDA, HITOSHI OHTO, YASUCHIKA TAKEISHI. (2010) HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THE DEPARTMENT OF HEMATOLOGY, FUKUSHIMA MEDICAL UNIVERSITY. FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 56:2, 107-114
CrossRef38
J M Vossen, A E Donker, M B A Heemskerk, J L W T j Lie, M H van Weel-Sipman, R G M Bredius, J D J Bakker, R M Egeler, M Oudshoorn. (2010) Unrelated donor marrow transplantation in children: transplant policy and outcome in Leiden Paediatrics SCT-Centre. Bone Marrow Transplantation 45:1, 87-95
CrossRef39
Svetlana Vojvodic, Stevan Popovic. (2010) Clinical relevance of KIRs in hematopoietic stem cell transplantation. Medicinski pregled 63:3-4, 215-219
CrossRef40
G. Bentley, R. Higuchi, B. Hoglund, D. Goodridge, D. Sayer, E. A. Trachtenberg, H. A. Erlich. (2009) High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens 74:5, 393-403
CrossRef41
Y. Morishima. (2009) Unrelated haematopoietic stem cell transplantation and bank. ISBT Science Series 4:n2, 318-322
CrossRef42
R Crocchiolo, F Ciceri, K Fleischhauer, R Oneto, B Bruno, S Pollichieni, N Sacchi, M P Sormani, R Fanin, G Bandini, F Bonifazi, A Bosi, A Rambaldi, P E Alessandrino, M Falda, A Bacigalupo. (2009) HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry. Bone Marrow Transplantation 44:9, 571-577
CrossRef43
Satoshi Nishiwaki, Koichi Miyamura, Aika Seto, Keisuke Watanabe, Mayumi Yanagisawa, Nobuhiko Imahashi, Makoto Shimba, Takahiko Yasuda, Yachiyo Kuwatsuka, Taku Oba, Seitaro Terakura, Yoshihisa Kodera. (2009) Impact of the basal metabolic ratio in predicting early deaths after allogeneic stem cell transplantation. American Journal of Hematology 84:9, 608-611
CrossRef44
Takanori Teshima, Koji Nagafuji, Hideho Henzan, Koichi Miyamura, Ken Takase, Michihiro Hidaka, Toshihiro Miyamoto, Katsuto Takenaka, Koichi Akashi, Mine Harada. (2009) Rituximab for the treatment of corticosteroid-refractory chronic graft-versus-host disease. International Journal of Hematology 90:2, 253-260
CrossRef45
Katrin Hacke, Rustom Falahati, Linda Flebbe-Rehwaldt, Noriyuki Kasahara, Karin M. L. Gaensler. (2009) Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunologic Research 44:1-3, 112-126
CrossRef46
Thirachit Chotsampancharoen, Kwan Gan, Kimberly A. Kasow, Raymond C. Barfield, Gregory A. Hale, Wing Leung. (2009) Iron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantation. Pediatric Transplantation 13:3, 348-352
CrossRef47
Koen van Besien, Jeanette Carreras, Philip J. Bierman, Brent R. Logan, Arturo Molina, Roberta King, Gene Nelson, Joseph W. Fay, Richard E. Champlin, Hillard M. Lazarus, Julie M. Vose, Parameswaran N. Hari. (2009) Unrelated Donor Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma: Long-Term Outcomes. Biology of Blood and Marrow Transplantation 15:5, 554-563
CrossRef48
Nicolaus Kröger, Tatjana Zabelina, Thomas Binder, Francis Ayuk, Ulrike Bacher, Gitta Amtsfeld, Heinrich Lellek, Johanna Schrum, Rolf Erttmann, Thomas Eiermann, Axel Zander. (2009) HLA-Mismatched Unrelated Donors as an Alternative Graft Source for Allogeneic Stem Cell Transplantation after Antithymocyte Globulin-Containing Conditioning Regimen. Biology of Blood and Marrow Transplantation 15:4, 454-462
CrossRef49
Y. Atsuta, R. Suzuki, T. Nagamura-Inoue, S. Taniguchi, S. Takahashi, S. Kai, H. Sakamaki, Y. Kouzai, M. Kasai, T. Fukuda, H. Azuma, M. Takanashi, S. Okamoto, M. Tsuchida, K. Kawa, Y. Morishima, Y. Kodera, S. Kato, . (2009) Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. Blood 113:8, 1631-1638
CrossRef50
T. Kawase, K. Matsuo, K. Kashiwase, H. Inoko, H. Saji, S. Ogawa, S. Kato, T. Sasazuki, Y. Kodera, Y. Morishima, . (2009) HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. Blood 113:12, 2851-2858
CrossRef51
Tetsuya Nishida, Tohru Murayama, Hisamaru Hirai, Shinichiro Okamoto, Hiroshi Sao, Masamichi Hara, Heiwa Kanamori, Yoshiko Atsuta, Keitaro Matsuo, Yasuo Morishima, Yoshihisa Kodera. (2009) Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients. International Journal of Hematology 89:1, 98-105
CrossRef52
Andrea Velardi, Loredana Ruggeri, Antonella Mancusi, Emanuela Burchielli, Katia Perruccio, Franco Aversa, Massimo F. Martelli, . (2008) Clinical impact of natural killer cell reconstitution after allogeneic hematopoietic transplantation. Seminars in Immunopathology 30:4, 489-503
CrossRef53
Jason Dehn, Mukta Arora, Stephen Spellman, Michelle Setterholm, Mary Horowitz, Dennis Confer, Daniel Weisdorf. (2008) Unrelated Donor Hematopoietic Cell Transplantation: Factors Associated with a Better HLA Match. Biology of Blood and Marrow Transplantation 14:12, 1334-1340
CrossRef54
Sung-Won Kim, Keitaro Matsuo, Takahiro Fukuda, Masamichi Hara, Kosei Matsue, Shuichi Taniguchi, Tetsuya Eto, Mitsune Tanimoto, Atsushi Wake, Kazuo Hatanaka, Shinji Nakao, Yoji Ishida, Mine Harada, Atae Utsunomiya, Masahiro Imamura, Yoshinobu Kanda, Kazutaka Sunami, Fumio Kawano, Yoichi Takaue, Takanori Teshima. (2008) Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies. International Journal of Hematology 88:3, 324-330
CrossRef55
Effie W Petersdorf. (2008) Optimal HLA matching in hematopoietic cell transplantation. Current Opinion in Immunology 20:5, 588-593
CrossRef56
Rene Duquesnoy, Stephen Spellman, Michael Haagenson, Tao Wang, Mary M. Horowitz, Machteld Oudshoorn. (2008) HLAMatchmaker-Defined Triplet Matching Is Not Associated with Better Survival Rates of Patients with Class I HLA Allele Mismatched Hematopoietic Cell Transplants from Unrelated Donors. Biology of Blood and Marrow Transplantation 14:9, 1064-1071
CrossRef57
Francis Ayuk, Galina Diyachenko, Tatjana Zabelina, Christine Wolschke, Boris Fehse, Ulrike Bacher, Rudolf Erttmann, Nicolaus Kröger, Axel R. Zander. (2008) Comparison of Two Doses of Antithymocyte Globulin in Patients Undergoing Matched Unrelated Donor Allogeneic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 14:8, 913-919
CrossRef58
D A Wall, K W Chan. (2008) Selection of cord blood unit(s) for transplantation. Bone Marrow Transplantation 42:1, 1-7
CrossRef59
MM Imanguli, I Alevizos, R Brown, SZ Pavletic, JC Atkinson. (2008) Oral graft-versus-host disease. Oral Diseases 14:5, 396-412
CrossRef60
Daniel Weisdorf, Stephen Spellman, Michael Haagenson, Mary Horowitz, Stephanie Lee, Claudio Anasetti, Michelle Setterholm, Rebecca Drexler, Martin Maiers, Roberta King, Dennis Confer, John Klein. (2008) Classification of HLA-Matching for Retrospective Analysis of Unrelated Donor Transplantation: Revised Definitions to Predict Survival. Biology of Blood and Marrow Transplantation 14:7, 748-758
CrossRef61
E Lanino, N Sacchi, C Peters, S Giardino, V Rocha, G Dini. (2008) Strategies of the donor search for children with second CR ALL lacking a matched sibling donor. Bone Marrow Transplantation 41, S75-S79
CrossRef62
Marcelo C. Pasquini. (2008) Impact of graft-versus-host disease on survival. Best Practice & Research Clinical Haematology 21:2, 193-204
CrossRef63
John A. Hansen, Effie W. Petersdorf, Ming-Tseh Lin, Steven Wang, Jason W. Chien, Barry Storer, Paul J. Martin. (2008) Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes. Immunologic Research 41:1, 56-78
CrossRef64
Daniel Weisdorf. (2008) Should all unrelated donors for transplantation be matched?. Best Practice & Research Clinical Haematology 21:1, 79-83
CrossRef65
Sonali Chaudhury, Arleen D. Auerbach, Nancy A. Kernan, Trudy N. Small, Susan E. Prockop, Andromachi Scaradavou, Glenn Heller, Suzanne Wolden, Richard J. O’Reilly, Farid Boulad. (2008) Fludarabine-based cytoreductive regimen and T-cell-depleted grafts from alternative donors for the treatment of high-risk patients with Fanconi anaemia. British Journal of Haematology 140:6, 644-655
CrossRef66
Toshio Yabe, Keitaro Matsuo, Kouyuki Hirayasu, Koichi Kashiwase, Sumiyo Kawamura-Ishii, Hidenori Tanaka, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Kazunori Nakajima, Katsushi Tokunaga, Hidetoshi Inoko, Hiroo Saji, Seishi Ogawa, Takeo Juji, Takehiko Sasazuki, Yoshihisa Kodera, Yasuo Morishima. (2008) Donor Killer Immunoglobulin-Like Receptor (KIR) Genotype-Patient Cognate KIR Ligand Combination and Antithymocyte Globulin Preadministration Are Critical Factors in Outcome of HLA-C-KIR Ligand-Mismatched T Cell–Replete Unrelated Bone Marrow Transplantation. Biology of Blood and Marrow Transplantation 14:1, 75-87
CrossRef67
Alejandro Madrigal, Bronwen E. Shaw. (2008) Immunogenetic factors in donors and patients that affect the outcome of hematopoietic stem cell transplantation. Blood Cells, Molecules, and Diseases 40:1, 40-43
CrossRef68
Philippe Guardiola, Mathieu Kuentz, Frédéric Garban, Didier Blaise, Josy Reiffers, Michel Attal, Agnès Buzyn, Bruno Lioure, Pierre Bordigoni, Nathalie Fegueux, Marie-Laure Tanguy, Jean-Paul Vernant, Eliane Gluckman, Gérard Socié. (2008) Second early allogeneic stem cell transplantations for graft failure in acute leukaemia, chronic myeloid leukaemia and aplastic anaemia. British Journal of Haematology 111:1, 292
CrossRef69
Arnold Van Der Meer, Irma Joosten, Anton V. Schattenberg, Theo J. M. De Witte, Wil A. Allebes. (2008) Cytotoxic T-lymphocyte precursor frequency (CTLp-f) as a tool for distinguishing permissible from non-permissible class I mismatches in T-cell-depleted allogeneic bone marrow transplantation. British Journal of Haematology 111:2, 685
CrossRef70
Stephanie J. Lee, Naynesh Kamani, Dennis L. Confer. (2008) Principles and Tools for Selection of Umbilical Cord Blood and Unrelated Adult Donor Grafts. Biology of Blood and Marrow Transplantation 14:1, 112-119
CrossRef71
S. J. Lee, J. Klein, M. Haagenson, L. A. Baxter-Lowe, D. L. Confer, M. Eapen, M. Fernandez-Vina, N. Flomenberg, M. Horowitz, C. K. Hurley, H. Noreen, M. Oudshoorn, E. Petersdorf, M. Setterholm, S. Spellman, D. Weisdorf, T. M. Williams, C. Anasetti. (2007) High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 110:13, 4576-4583
CrossRef72
B. E. Shaw, T. A. Gooley, M. Malkki, J. A. Madrigal, A. B. Begovich, M. M. Horowitz, A. Gratwohl, O. Ringden, S. G. E. Marsh, E. W. Petersdorf. (2007) The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood 110:13, 4560-4566
CrossRef73
Jolanta B. Perz, Richard Szydlo, Ruhena Sergeant, Jaime Sanz, Derville O'Shea, Thahmina Khan, Nick Davey, Sandra Loaiza, John Davis, Jane F. Apperley, Eduardo Olavarria. (2007) Impact of HLA class I and class II DNA high-resolution HLA typing on clinical outcome in adult unrelated stem cell transplantation after in vivo T-cell depletion with alemtuzumab. Transplant Immunology 18:2, 179-185
CrossRef74
Dai Maruyama, Takahiro Fukuda, Ruri Kato, Satoshi Yamasaki, Eiji Usui, Yuriko Morita-Hoshi, Sung-Won Kim, Shin-ichiro Mori, Yuji Heike, Atsushi Makimoto, Kinuko Tajima, Ryuji Tanosaki, Kensei Tobinai, Yoichi Takaue. (2007) Comparable Antileukemia/Lymphoma Effects in Nonremission Patients Undergoing Allogeneic Hematopoietic Cell Transplantation with a Conventional Cytoreductive or Reduced-Intensity Regimen. Biology of Blood and Marrow Transplantation 13:8, 932-941
CrossRef75
Mari Malkki, Ted A. Gooley, Mary M. Horowitz, Lena Absi, Frank T. Christiansen, Jan J. Cornelissen, Anne Dormoy, Valerie Dubois, Katia Gagne, Eliane Gluckman, Michael D. Haagenson, Machteld Oudshoorn, Stephen Spellman, Effie W. Petersdorf. (2007) Mapping MHC-Resident Transplantation Determinants. Biology of Blood and Marrow Transplantation 13:8, 986-995
CrossRef76
Pascale Loiseau, Marc Busson, Marie-Lorraine Balere, Anne Dormoy, Jean-Denis Bignon, Katia Gagne, Lucette Gebuhrer, Valérie Dubois, Isabelle Jollet, Monique Bois, Pascale Perrier, Dominique Masson, Agnès Moine, Léna Absi, Denis Reviron, Virginia Lepage, Ryad Tamouza, Antoine Toubert, Evelyne Marry, Zina Chir, Jean-Pierre Jouet, Didier Blaise, Dominique Charron, Colette Raffoux. (2007) HLA Association with Hematopoietic Stem Cell Transplantation Outcome: The Number of Mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 Is Strongly Associated with Overall Survival. Biology of Blood and Marrow Transplantation 13:8, 965-974
CrossRef77
Sung-Yong Kim, Jong-Wook Lee, Jihyang Lim, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Woo-Sung Min, Chun-Choo Kim. (2007) Unrelated Donor Bone Marrow Transplants for Severe Aplastic Anemia with Conditioning Using Total Body Irradiation and Cyclophosphamide. Biology of Blood and Marrow Transplantation 13:7, 863-870
CrossRef78
Effie W. Petersdorf. (2007) Risk assessment in haematopoietic stem cell transplantation: Histocompatibility. Best Practice & Research Clinical Haematology 20:2, 155-170
CrossRef79
Yoshiko Atsuta, Ritsuro Suzuki, Ayami Yoshimi, Hisashi Gondo, Junji Tanaka, Akira Hiraoka, Koji Kato, Ken Tabuchi, Masahiro Tsuchida, Yasuo Morishima, Makoto Mitamura, Keisei Kawa, Shunichi Kato, Tokiko Nagamura, Minoko Takanashi, Yoshihisa Kodera. (2007) Unification of hematopoietic stem cell transplantation registries in Japan and establishment of the TRUMP system. International Journal of Hematology 86:3, 269-274
CrossRef80
E. W. Petersdorf, T. Gooley, M. Malkki, M. Horowitz, . (2007) Clinical significance of donor-recipient HLA matching on survival after myeloablative hematopoietic cell transplantation from unrelated donors. Tissue Antigens 69, 25-30
CrossRef81
E. Garino, J. Miertus, M. Berrino, F. Bertinetto, P. Caropreso, V. Gay, G. Mazzola, F. Tondat, V. Frecer, S. Miertus, A. Amoroso. (2007) Molecular aspects of a novel HLA-A*02 allele (A*0297): the first HLA class I allele mutated at codon 232. Tissue Antigens 69:4, 342-347
CrossRef82
M. Malkki, T. Gooley, M. Horowitz, E. W. Petersdorf, . (2007) MHC class I, II, and III microsatellite marker matching and survival in unrelated donor hematopoietic cell transplantation. Tissue Antigens 69, 46-49
CrossRef83
William Ying Khee Hwang, Miny Samuel, Daryl Tan, Liang Piu Koh, Winston Lim, Yeh Ching Linn. (2007) A Meta-Analysis of Unrelated Donor Umbilical Cord Blood Transplantation versus Unrelated Donor Bone Marrow Transplantation in Adult and Pediatric Patients. Biology of Blood and Marrow Transplantation 13:4, 444-453
CrossRef84
Y. Morishima, T. Kawase, M. Malkki, E. W. Petersdorf, . (2007) Effect of HLA-A2 allele disparity on clinical outcome in hematopoietic cell transplantation from unrelated donors. Tissue Antigens 69, 31-35
CrossRef85
Elaine R. Morgan, Jennifer Girod, John S. Rinehart. (2007) Having a child to save a sibling: Reassessing risks and benefits of creating stem cell donors. Pediatric Blood & Cancer 48:3, 249-253
CrossRef86
Tomoki Kikuchi, Taeko K. Naruse, Makoto Onizuka, Suyun Li, Tetsuaki Kimura, Akira Oka, Yasuo Morishima, Jerzy K. Kulski, Shingo Ichimiya, Noriyuki Sato, Hidetoshi Inoko. (2007) Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22. Immunogenetics 59:2, 99-108
CrossRef87
Koji Kato, Yoshinobu Kanda, Tetsuya Eto, Tsuyoshi Muta, Hisashi Gondo, Shuichi Taniguchi, Tsunefumi Shibuya, Atae Utsunomiya, Takakazu Kawase, Shunichi Kato, Yasuo Morishima, Yoshihisa Kodera, Mine Harada. (2007) Allogeneic Bone Marrow Transplantation from Unrelated Human T-Cell Leukemia Virus-I–negative Donors for Adult T-Cell Leukemia/Lymphoma: Retrospective Analysis of Data from the Japan Marrow Donor Program. Biology of Blood and Marrow Transplantation 13:1, 90-99
CrossRef88
Hee-Je Kim. (2007) HLA Mismatched Allogeneic Hematopoietic Stem Cell Transplantation. The Korean Journal of Hematology 42:1, 1
CrossRef89
Loredana Ruggeri, Franco Aversa, Massimo F. Martelli, Andrea Velardi. (2006) Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self. Immunological Reviews 214:1, 202-218
CrossRef90
Peter A. Horn, Holger A. Elsner, Rainer Blasczyk. (2006) Tissue typing for hematopoietic cell transplantation: HLA-DQB1 typing should be included. Pediatric Transplantation 10:6, 753-754
CrossRef91
Sherif S. Farag, Andrea Bacigalupo, Mary Eapen, Carolyn Hurley, Bo Dupont, Michael A. Caligiuri, Christian Boudreau, Gene Nelson, Machteld Oudshoorn, Jon van Rood, Andrea Velardi, Martin Maiers, Michelle Setterholm, Dennis Confer, Phillip E. Posch, Claudio Anasetti, Naynesh Kamani, Jeffrey S. Miller, Daniel Weisdorf, Stella M. Davies. (2006) The Effect of KIR Ligand Incompatibility on the Outcome of Unrelated Donor Transplantation: A Report from the Center for International Blood and Marrow Transplant Research, the European Blood and Marrow Transplant Registry, and the Dutch Registry. Biology of Blood and Marrow Transplantation 12:8, 876-884
CrossRef92
V T Ho, H T Kim, D Liney, E Milford, J Gribben, C Cutler, S J Lee, J H Antin, R J Soiffer, E P Alyea. (2006) HLA-C mismatch is associated with inferior survival after unrelated donor non-myeloablative hematopoietic stem cell transplantation. Bone Marrow Transplantation 37:9, 845-850
CrossRef93
Y Chalandon, J-M Tiercy, U Schanz, T Gungor, R Seger, J Halter, C Helg, B Chapuis, A Gratwohl, A Tichelli, G Nicoloso de Faveri, E Roosnek, J R Passweg. (2006) Impact of high-resolution matching in allogeneic unrelated donor stem cell transplantation in Switzerland. Bone Marrow Transplantation 37:10, 909-916
CrossRef94
Hillard M. Lazarus, Waleska S. Perez, John P. Klein, Craig Kollman, B. Bate-Boyle, Christopher N. Bredeson, Robert Peter Gale, Robert B. Geller, Armand Keating, Mark R. Litzow, David I. Marks, Carole B. Miller, J. Douglas Rizzo, Thomas R. Spitzer, Daniel J. Weisdorf, Mei-Jie Zhang, Mary M. Horowitz. (2006) Autotransplantation versus HLA-matched unrelated donor transplantation for acute myeloid leukaemia: a retrospective analysis from the Center for International Blood and Marrow Transplant Research. British Journal of Haematology 132:6, 755-769
CrossRef95
K. Kitcharoen, C.S. Witt, A.V. Romphruk, F.T. Christiansen, C. Leelayuwat. (2006) MICA, MICB, and MHC Beta Block Matching in Bone Marrow Transplantation: Relevance to Transplantation Outcome. Human Immunology 67:3, 238-246
CrossRef96
S Terakura, M Murata, T Nishida, N Emi, Y Akatsuka, Y Morishima, Y Kodera, T Naoe. (2006) Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients. Bone Marrow Transplantation 37:4, 381-386
CrossRef97
Y Atsuta, R Suzuki, K Yamamoto, S Terakura, H Iida, A Kohno, T Naoe, K Yano, A Wakita, H Taji, M Hamaguchi, Y Kodera, H Sao, Y Morishima, N Hamajima, Y Morishita. (2006) Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation. Bone Marrow Transplantation 37:3, 289-296
CrossRef98
Effie W. Petersdorf, Mari Malkki. (2006) Genetics of Risk Factors for Graft-Versus-Host Disease. Seminars in Hematology 43:1, 11-23
CrossRef99
G La Nasa, G Caocci, F Argiolu, C Giardini, F Locatelli, A Vacca, M G Orofino, E Piras, M C Addari, A Ledda, L Contu. (2005) Unrelated donor stem cell transplantation in adult patients with thalassemia. Bone Marrow Transplantation 36:11, 971-975
CrossRef100
Yoshinobu Kanda, Hisashi Sakamaki, Hiroshi Sao, Shinichiro Okamoto, Yoshihisa Kodera, Ryuji Tanosaki, Masaharu Kasai, Akira Hiraoka, Satoshi Takahashi, Shuichi Miyawaki, Takakazu Kawase, Yasuo Morishima, Shunichi Kato. (2005) Effect of Conditioning Regimen on the Outcome of Bone Marrow Transplantation from an Unrelated Donor. Biology of Blood and Marrow Transplantation 11:11, 881-889
CrossRef101
GIORGIO NASA, FRANCA ARGIOLU, CLAUDIO GIARDINI, ANDREA PESSION, FRANCA FAGIOLI, GIOVANNI CAOCCI, ADRIANA VACCA, PIERO STEFANO, EUGENIA PIRAS, ANTONIO LEDDA, ANTONIO PIRODDI, ROBERTO LITTERA, SONIA NESCI, FRANCO LOCATELLI. (2005) Unrelated Bone Marrow Transplantation for β-Thalassemia Patients: The Experience of the Italian Bone Marrow Transplant Group. Annals of the New York Academy of Sciences 1054:1, 186-195
CrossRef102
Jean-Denis Bignon, Katia Gagne. (2005) KIR matching in hematopoietic stem cell transplantation. Current Opinion in Immunology 17:5, 553-559
CrossRef103
K Yumura-Yagi, M Inoue, N Sakata, T Okamura, M Yasui, A Sawada, E Sato, K Chayama, C Endo, M Sasabe, T Miyamura, Y-D Park, T Nakano, J Inagaki, T Kishimoto, K Nomura, I Saito, S Hamada, T Nakano, Y Hashii, K Kawa. (2005) Unrelated donor bone marrow transplantation for 100 pediatric patients: a single institute's experience. Bone Marrow Transplantation 36:4, 307-313
CrossRef104
Judith Reinders, Erik H. Rozemuller, Henny G. Otten, Anna J.S. Houben, Anne Dormoy, Arend Mulder, Jan G. van den Tweel, Eefke J. Petersen, Marcel G.J. Tilanus. (2005) Identification of HLA-A*0111N: A Synonymous Substitution, Introducing an Alternative Splice Site in Exon 3, Silenced the Expression of an HLA-A Allele. Human Immunology 66:8, 912-920
CrossRef105
Takanori Teshima, Keitaro Matsuo, Kosei Matsue, Fumio Kawano, Shuichi Taniguchi, Masamichi Hara, Kazuo Hatanaka, Mitsune Tanimoto, Mine Harada, Shinji Nakao, Yasunobu Abe, Atsushi Wake, Tetsuya Eto, Yoshinobu Takemoto, Masahiro Imamura, Satoshi Takahashi, Yoji Ishida, Yoshinobu Kanda, Masaharu Kasai, Yoichi Takaue. (2005) Impact of human leucocyte antigen mismatch on graft-versus-host disease and graft failure after reduced intensity conditioning allogeneic haematopoietic stem cell transplantation from related donors. British Journal of Haematology 130:4, 575-587
CrossRef106
B. Pedron, K. Yakouben, D. Adjaoud, A. Auvrignon, J. Landman, V. Guerin, G. Leverger, E. Vilmer, G. Sterkers. (2005) Listing of Common HLA Alleles and Haplotypes Based on the Study of 356 Families Residing in the Paris, France, Area: Implications for Unrelated Hematopoietic Stem Cell Donor Selection. Human Immunology 66:6, 720-730
CrossRef107
Yoshihisa Kodera, Tetsuya Nishida, Tatsuo Ichinohe, Hiroo Saji. (2005) Human leukocyte antigen haploidentical hematopoietic stem cell transplantation: Indications and tentative outcomes in Japan. Seminars in Hematology 42:2, 112-118
CrossRef108
Effie W. Petersdorf, Mari Malkki. (2005) Human leukocyte antigen matching in unrelated donor hematopoietic cell transplantation. Seminars in Hematology 42:2, 76-84
CrossRef109
Seitaro Terakura, Makoto Murata, Tetsuya Nishida, Nobuhiko Emi, Yoshiki Akatsuka, Stanley R. Riddell, Yasuo Morishima, Yoshihisa Kodera, Tomoki Naoe. (2005) A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation. British Journal of Haematology 129:2, 221-228
CrossRef110
Fang Ya, Hein Putter. (2005) Probability prediction in multistate survival models for patients with chronic myeloid leukaemia. Journal of Huazhong University of Science and Technology [Medical Sciences] 25:1, 100-103
CrossRef111
Gerda C. Leitner, Gabriele Stiegler, Peter Kalhs, Hildegard T. Greinix, Werner Rabitsch, Christian Sillaber, Paul Hoecker, Simon Panzer. (2005) The influence of human platelet antigen match on the success of allogeneic peripheral blood progenitor cell transplantation following a reduced-intensity conditioning regimen. Transfusion 45:2, 195-201
CrossRef112
Junji Tanaka, Masahiro Asaka, Masahiro Imamura. (2005) Potential Role of Natural Killer Cell Receptor-Expressing Cells in Immunotherapy for Leukemia. International Journal of Hematology 81:1, 6-12
CrossRef113
Rocha, Vanderson, Labopin, Myriam, Sanz, Guillermo, Arcese, William, Schwerdtfeger, Rainer, Bosi, Alberto, Jacobsen, Niels, Ruutu, Tapani, de Lima, Marcos, Finke, Jürgen, Frassoni, Francesco, Gluckman, Eliane, . (2004) Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia. New England Journal of Medicine 351:22, 2276-2285
Full Text114
Effie W Petersdorf. (2004) HLA matching in allogeneic stem cell transplantation. Current Opinion in Hematology 11:6, 386-391
CrossRef115
Brigitte Kircher, C. Erik Hack, Anne M. Dickinson, Xiao N. Wang, Machteld Oudshoorn, Annemarie Sachs, Angela Wolbink, Dietger Niederwieser, Günther J. Eibl, Hans C. van Houwelingen, Els Goulmy. (2004) Towards functional transplant donor matching by measurement of granzyme A and granzyme B production levels. Journal of Immunological Methods 293:1-2, 51-59
CrossRef116
Charles G. Mullighan, Peter G. Bardy. (2004) Advances in the genomics of allogeneic haemopoietic stem cell transplantation. Drug Development Research 62:3, 273-292
CrossRef117
Tohru Nakagawa, Masahiro Kami, Akiko Hori, Sung-Won Kim, Naoko Murashige, Tamae Hamaki, Yukiko Kishi, Hiroyuki Fujimoto, Naoki Matsuoka, Eijiro Okajima, Motokiyo Komiyama, Ken-ichi Tobisu, Toshio Wakayama, Naokuni Uike, Kinuko Tajima, Atsushi Makimoto, Shinichiro Mori, Ryuji Tanosaki, Yoichi Takaue, Tadao Kakizoe. (2004) Allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen for treatment of metastatic renal cell carcinoma: single institution experience with a minimum 1-year follow-up. Experimental Hematology 32:7, 599-606
CrossRef118
Neil T. Young. (2004) Immunobiology of Natural Killer Lymphocytes in Transplantation. Transplantation 78:1, 1-6
CrossRef119
Yoshihisa Nagatoshi, Yoshifumi Kawano, Jun Okamura. (2004) Comparison of the outcomes of allogeneic bone marrow transplantation from partially mismatched related donors, matched sibling donors, and matched unrelated donors in Japanese pediatric patients: A single center result. Pediatric Transplantation 8:3, 260-266
CrossRef120
Kazunori Ohnishi, Akio Ino, Yuji Kishimoto, Noriko Usui, Chihiro Shimazaki, Shigeki Ohtake, Hirokuni Taguchi, Fumiharu Yagasaki, Masao Tomonaga, Tomomitsu Hotta, Ryuzo Ohno. (2004) Multicenter Prospective Study of Interferon 3 versus Allogeneic Stem Cell Transplantation for Patients with New Diagnoses of Chronic Myelogenous Leukemia. International Journal of Hematology 79:4, 345-353
CrossRef121
Franco Locatelli, Piero De Stefano. (2004) New insights into haematopoietic stem cell transplantation for patients with haemoglobinopathies. British Journal of Haematology 125:1, 3-11
CrossRef122
Martin Benesch, Christian Urban, Karl W. Sykora, Wolfgang Schwinger, Felix Zintl, Herwig Lackner, Peter Lang, Rupert Handgretinger. (2004) Transplantation of highly purified CD34+ progenitor cells from alternative donors in children with refractory severe aplastic anaemia. British Journal of Haematology 125:1, 58-63
CrossRef123
S. Li, H. Kawata, Y. Katsuyama, M. Ota, Y. Morishima, S. Mano, J.K. Kulski, T. Naruse, H. Inoko. (2004) Association of polymorphic MHC microsatellites with GVHD, survival, and leukemia relapse in unrelated hematopoietic stem cell transplant donor/recipient pairs matched at five HLA loci. Tissue Antigens 63:4, 362-368
CrossRef124
Eliane Gluckman, Vanderson Rocha, William Arcese, Gérard Michel, Guillermo Sanz, Ka-Wah Chan, Tsuneo A Takahashi, Juan Ortega, Alexandra Filipovich, Franco Locatelli, Shigetaka Asano, Franca Fagioli, Marcus Vowels, Anne Sirvent, Jean-Philippe Laporte, Karin Tiedemann, Sergio Amadori, Manuel Abecassis, Pierre Bordigoni, Blanca Diez, Peter J Shaw, Ajay Vora, Maurizio Caniglia, Federico Garnier, Irina Ionescu, Joan Garcia, Gesine Koegler, Paolo Rebulla, Sylvie Chevret, on behalf of the Eurocord Group. (2004) Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice. Experimental Hematology 32:4, 397-407
CrossRef125
Yoshiki Akatsuka, Yasuo Morishima. (2004) Major and minor histocompatibility antigens in allogeneic hematopoietic stem cell transplantation. Current Opinion in Organ Transplantation 9:1, 64-71
CrossRef126
Lin, Ming-Tseh, Storer, Barry, Martin, Paul J., Tseng, Li-Hui, Gooley, Ted, Chen, Pei-Jer, Hansen, John A., . (2003) Relation of an Interleukin-10 Promoter Polymorphism to Graft-versus-Host Disease and Survival after Hematopoietic-Cell Transplantation. New England Journal of Medicine 349:23, 2201-2210
Full Text127
Mei Han, Yue-Qing Tan, Yanzheng Zhang, Jeannette Tsai, Rob Vorhaben, J.Roberto Moraes, M.Elisa Moraes, Peter Stastny. (2003) Multiplex single nucleotide extension: a robust and high throughput method for HLA-A locus typing. Human Immunology 64:12, 1111-1122
CrossRef128
Eric J. Lowe, Victoria Turner, Rupert Handgretinger, Edwin M. Horwitz, Ely Benaim, Gregory A. Hale, Paul Woodard, Wing Leung. (2003) T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation. British Journal of Haematology 123:2, 323-326
CrossRef129
T. M. Cao, B. Lo, E. A. Ranheim, F. C. Grumet, J. A. Shizuru. (2003) Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice. Proceedings of the National Academy of Sciences 100:20, 11571-11576
CrossRef130
D. C. Jones, N. T. Young. (2003) Natural killer receptor repertoires in transplantation. European Journal of Immunogenetics 30:3, 169-176
CrossRef131
Masahiro Kami, Yoichi Takaue. (2003) Development of Reduced-intensity Hematopoietic Stem Cell Transplantation in the National Cancer Center Hospital, Japan. Therapeutic Apheresis and Dialysis 7:3, 318-328
CrossRef132
Chatchada Karanes. (2003) Unrelated donor stem cell transplant: donor selection and search process. Pediatric Transplantation 7, 59-64
CrossRef133
E.W. Petersdorf, C. Anasetti, P.J. Martin, J.A. Hansen. (2003) Tissue typing in support of unrelated hematopoietic cell transplantation. Tissue Antigens 61:1, 1-11
CrossRef134
Akira Tomonari, Tohru Iseki, Jun Ooi, Satoshi Takahashi, Koji Ishii, Tsutomu Takahashi, Motohiro Shindo, Fumitaka Nagamura, Kaoru Uchimaru, Hitomi Nagayama, Naoki Shirafuji, Arinobu Tojo, Kenzaburo Tani, Shigetaka Asano. (2002) Using Related Donors other Than Genotypically HLA-Matched Siblings in Allogeneic Hematopoietic Stem Cell Transplantation for Hematologic Disease: A Single Institution Experience in Japan. International Journal of Hematology 76:4, 354-359
CrossRef135
Paul B. Massion, Alain M. Dive, Chantal Doyen, Pierre Bulpa, Jacques Jamart, André Bosly, Etienne Installé. (2002) Prognosis of hematologic malignancies does not predict intensive care unit mortality. Critical Care Medicine 30:10, 2260-2270
CrossRef136
Effie W. Petersdorf, Claudio Anasetti, Paul J. Martin, John A. Hansen. (2002) Impact of molecular histocompatibility typing on outcome of unrelated donor hematopoietic cell transplantation. Current Opinion in Organ Transplantation 7:3, 279-285
CrossRef137
David Nachbaur, Brigitte Eibl, Gaby Kropshofer, Bernhard Meister, Andrea Mitterschiffthaler, Harald Schennach, Gottfried Fischer, Martin Kopp, Eberhard Gunsilius, Gunther Gastl. (2002) In Vivo T Cell Depletion with Low-Dose Rabbit Antithymocyte Globulin Results in Low Transplant-Related Mortality and Low Relapse Incidence Following Unrelated Hematopoietic Stem Cell Transplantation. Journal of Hematotherapy <html_ent glyph="@amp;" ascii="&"/> Stem Cell Research 11:4, 731-737
CrossRef138
Gottfried Fischer. (2002) Immunogenetic selection of donors for haematopoietic stem cell transplantation: an approach. Transplant Immunology 10:2-3, 223-225
CrossRef139
Jean-Marie Tiercy, Jean Villard, Eddy Roosnek. (2002) Selection of unrelated bone marrow donors by serology, molecular typing and cellular assays. Transplant Immunology 10:2-3, 215-221
CrossRef140
Robin E Miller, John D Fayen, Shaden F Mohammad, Kevin Stein, Suzanne Kadereit, Kathleen Daum Woods, R.Michael Sramkoski, James W Jacobberger, Dennis Templeton, Susan B Shurin, Mary J Laughlin. (2002) Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes. Experimental Hematology 30:7, 738-744
CrossRef141
H.-A. Elsner, R. Blasczyk. (2002) Sequence similarity matching: proposal of a structure-based rating system for bone marrow transplantation. European Journal of Immunogenetics 29:3, 229-236
CrossRef142
Makoto Yazaki, Toshitada Takahashi, Keigo Mizutani, Yasuhiko Ito, Hiroshi Wakiguchi, Masami Inoue, Keisei Kawa, Koji Kato, Toro Kato, Hidehiko Saito, Hajime Togari. (2002) Human leucocyte antigen-Cw-specific cytotoxic T lymphocytes generated from naive cord blood used for cord blood stem cell transplantation. British Journal of Haematology 117:4, 893-898
CrossRef143
E.Y. Song, M.H. Park, S.J. Kang, H.J. Park, B.C. Kim, K. Tokunaga, T. Akaza, T. Juji. (2002) HLA class II allele and haplotype frequencies in Koreans based on 107 families. Tissue Antigens 59:6, 475-486
CrossRef144
J.-M. Tiercy. (2002) Molecular basis of HLA polymorphism: implications in clinical transplantation. Transplant Immunology 9:2-4, 173-180
CrossRef145
M Oudshoorn, I.I.N Doxiadis, P.M van den Berg-Loonen, C.E.M Voorter, W Verduyn, F.H.J Claas. (2002) Functional versus structural matching: can the CTLp test be replaced by HLA allele typing?. Human Immunology 63:3, 176-184
CrossRef146
Carolyn Katovich Hurley. (2002) HLA diversity: Detection and impact on unrelated hematopoietic stem cell · donor characterization and selection. International Journal of Hematology 76:S2, 152-154
CrossRef147
Christine S Falk, Dolores J Schendel. (2002) Allogeneic MHC class I ligands and their role in positive and negative regulation of human cytotoxic effector cells. Human Immunology 63:1, 8-19
CrossRef148
Rubinstein, Pablo, . (2001) HLA Matching for Bone Marrow Transplantation — How Much Is Enough?. New England Journal of Medicine 345:25, 1842-1844
Full Text149
P.Jean Henslee-Downey. (2001) Allogeneic transplantation across major HLA barriers. Best Practice & Research Clinical Haematology 14:4, 741-754
CrossRef150
B.E. Shaw, J.A. Madrigal, M. Potter. (2001) Improving the outcome of unrelated donor stem cell transplantation by molecular matching. Blood Reviews 15:4, 167-174
CrossRef151
Claudio Anasetti, Effie W. Petersdorf, Paul J. Martin, Ann Woolfrey, John A. Hansen. (2001) Trends in transplantation of hematopoietic stem cells from unrelated donors. Current Opinion in Hematology 8:6, 337-341
CrossRef152
Effie Petersdorf, Claudio Anasetti, Paul J Martin, Ann Woolfrey, Anajane Smith, Eric Mickelson, Mari Malkki, Ming-Tseh Lin, John A Hansen. (2001) Genomics of unrelated-donor hematopoietic cell transplantation. Current Opinion in Immunology 13:5, 582-589
CrossRef153
Arnold van der Meer, Wil A. Allebes, Jos Paardekooper, Jos Ruiter, Irma Joosten. (2001) HLA-C MISMATCHES INDUCE STRONG CYTOTOXIC T-CELL REACTIVITY IN THE PRESENCE OF AN ADDITIONAL DRB/DQB MISMATCH AND AFFECT NK CELL???MEDIATED ALLOREACTIVITY. Transplantation 72:5, 923-929
CrossRef154
R. Tamouza, V. Schaeffer, F. Marzais, J.C. Poirier, C. Fortier, R. Ramasawmy, R. Sghiri, R. Krishnamoorthy, A. Toubert, D. Charron. (2001) A new HLA-Cw allele (Cw*1510), identified in a French Caucasian individual. Tissue Antigens 58:2, 107-108
CrossRef155
Thomas M. Williams. (2001) Human Leukocyte Antigen Gene Polymorphism and the Histocompatibility Laboratory. The Journal of Molecular Diagnostics 3:3, 98-104
CrossRef156
Eliane Gluckman, Vanderson Rocha, Sylvie Chevret. (2001) RESULTS OF UNRELATED UMBILICAL CORD BLOOD HEMATOPOIETIC STEM CELL TRANSPLANTATION. Reviews in Clinical and Experimental Hematology 5:2, 87-99
CrossRef157
Nicolaus Kroger, Tatjana Zabelina, William Kruger, Helmut Renges, Norbert Stute, Johanna Schrum, Hartmut Kabisch, Philippe Schafhausen, Nicole Jaburg, Cornelius Loliger, Peter Schafer, Axel Hinke, Axel R. Zander. (2001) Patient cytomegalovirus seropositivity with or without reactivation is the most important prognostic factor for survival and treatment-related mortality in stem cell transplantation from unrelated donors using pretransplant in vivo T-cell depletion with anti-thymocyte globulin. British Journal of Haematology 113:4, 1060-1071
CrossRef158
Marcos De Lima, Richard Champlin. (2001) UNRELATED DONOR HEMATOPOIETIC TRANSPLANTATION. Reviews in Clinical and Experimental Hematology 5:2, 100-134
CrossRef159
Wing H Leung, Victoria Turner, Stacye L Richardson, Ely Benaim, Gregory Hale, Edwin M Horwitz, Paul Woodard, Laura C Bowman. (2001) Effect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donors. Human Immunology 62:4, 399-407
CrossRef160
Kenichi Yamada, Emiko Hatakeyama, Tateo Sakamaki, Motonobu Nishimura, Seiji Arita, Kaoru Sakamoto, Kinichi Hamaguchi, Kazuaki Nakajima, Masaaki Otsuka, Kazunari Tanabe. (2001) INVOLVEMENT OF PLATELET-DERIVED GROWTH FACTOR AND HISTOCOMPATIBILITY OF DRB 1 IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY1. Transplantation 71:7, 936-941
CrossRef161
Effie W. Petersdorf, Ted Gooley, Mari Malkki, Claudio Anasetti, Paul Martin, Ann Woolfrey, Anajane Smith, Eric Mickelson, John A. Hansen. (2001) The biological significance of HLA-DP gene variation in haematopoietic cell transplantation. British Journal of Haematology 112:4, 988-994
CrossRef162
Kei Ohnuma, Keiichi Isoyama, Koichiro Ikuta, Yasunori Toyoda, Junko Nakamura, Fumiaki Nakajima, Masahiro Tsuchida, Mutsuro Ohira, Aiko Suminoe, Toshiro Hara, Hirokazu Nishihira. (2001) Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies. British Journal of Haematology 112:4, 981-987
CrossRef163
Shintaro Shiobara, Shinji Nakao, Mikio Ueda, Hirohito Yamazaki, Satoshi Takahashi, Shigetaka Asano, Hiromasa Yabe, Shunichi Kato, Shion Imoto, Atsuo Maruta, Takashi Yoshida, Hisashi Gondo, Yasuo Morishima, Yoshihisa Kodera. (2001) Donor Leukocyte Infusion for Japanese Patients with Relapsed Leukemia After Allogeneic Bone Marrow Transplantation: Indications and Dose Escalation. Therapeutic Apheresis and Dialysis 5:1, 40-45
CrossRef164
T. Akesaka, K. Kashiwase, Y. Ishikawa, H. Tanaka, M. Shimizu, S. Kawai, T. Akaza, T. Takahashi, T. Juji. (2001) Allele frequency of HLA-B39 in the Japanese population and identification of a novel B39 allele, B*3923. Tissue Antigens 57:2, 169-172
CrossRef165
J.-M. Boiron, D. Lerner, A. Pigneux, C. Fabéres, D. Bordessoule, P. Turlure, P. Cony-makhoul, F. Hau, B. Dazey, P. Agape, J. Reiffers, G. Marit. (2001) Allogeneic Transplantation for Patients with Advanced Acute Leukemia: a Single Center Retrospective Study of 92 Patients. Leukemia & Lymphoma 41:3-4, 285-296
CrossRef166
C. Craddock, R. M. Szydlo, F. Dazzi, E. Olavarria, K. Cwynarski, A. Yong, P. Brookes, J. de la Fuente, E. Kanfer, J. F. Apperley, J. M. Goldman. (2001) Cytomegalovirus seropositivity adversely influences outcome after T-depleted unrelated donor transplant in patients with chronic myeloid leukaemia: the case for tailored graft-versus-host disease prophylaxis. British Journal of Haematology 112:1, 228-236
CrossRef167
Kikuya Sugiura, Hiroko Hisha, Junji Ishikawa, Yasushi Adachi, Shigeru Taketani, Shinryu Lee, Takashi Nagahama, Susumu Ikehara. (2001) Major Histocompatibility Complex Restriction Between Hematopoietic Stem Cells and Stromal Cells In Vitro. Stem Cells 19:1, 46-58
CrossRef168
Steven N. Wolff. (2000) Hematopoietic cell transplant from volunteer unrelated or partially matched related donors: recent developments. Current Opinion in Organ Transplantation 5:4, 372-381
CrossRef169
Arnold van der Meer, Irma Joosten, Anton V. Schattenberg, Theo J. M. de Witte, Wil A. Allebes. (2000) Cytotoxic T-lymphocyte precursor frequency (CTLp-f) as a tool for distinguishing permissible from non-permissible class I mismatches in T-cell-depleted allogeneic bone marrow transplantation. British Journal of Haematology 111:2, 685-694
CrossRef170
Philippe Guardiola, Mathieu Kuentz, Frederic Garban, Didier Blaise, Josy Reiffers, Michel Attal, Agnes Buzyn, Bruno Lioure, Pierre Bordigoni, Nathalie Fegueux, Marie-Laure Tanguy, Jean-Paul Vernant, Eliane Gluckman, Gerard Socie, . (2000) Second early allogeneic stem cell transplantations for graft failure in acute leukaemia, chronic myeloid leukaemia and aplastic anaemia. British Journal of Haematology 111:1, 292-302
CrossRef171
A. Sanchez-Mazas, Q.-G. Steiner, C. Grundschober, J.-M. Tiercy. (2000) The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans. Tissue Antigens 56:4, 303-312
CrossRef172
Kei Ohnuma, Keiichi Isoyama, Koichiro Ikuta, Yasunori Toyoda, Junko Nakamura, Fumiaki Nakajima, Hirokazu Nishihira. (2000) The Influence of HLA Genotyping Compatibility on Clinical Outcome after Cord Blood Transplantation from Unrelated Donors. Journal of Hematotherapy <html_ent glyph="@amp;" ascii="&"/> Stem Cell Research 9:4, 541-550
CrossRef173
W. Helmberg, J. Hegland, C.K. Hurley, M. Maiers, S.G.E. Marsh, C. Muller, E.H. Rozemuller. (2000) Going back to the roots: effective utilisation of HLA typing information for bone marrow registries requires full knowledge of the DNA sequences of the oligonucleotide reagents used in the testing. Tissue Antigens 56:1, 99-102
CrossRef174
M.H. Park, D.H. Whang, S.J. Kang, K.S. Han. (2000) HLA-A*02 allele frequencies and haplotypic associations in Koreans. Tissue Antigens 55:3, 250-256
CrossRef175
Claudio Anasetti, Effie W. Petersdorf, Paul J. Martin, Ann Woolfrey, John A. Hansen. (2000) Improving availability and safety of unrelated donor transplants. Current Opinion in Oncology 12:2, 121-126
CrossRef176
Eric M Mickelson, Effie Petersdorf, Claudio Anasetti, Paul Martin, Ann Woolfrey, John A Hansen. (2000) HLA matching in hematopoietic cell transplantation. Human Immunology 61:2, 92-100
CrossRef177
Campbell Witt, David Sayer, Filomena Trimboli, Melanie Saw, Richard Herrmann, Paul Cannell, David Baker, Frank Christiansen. (2000) Unrelated donors selected prospectively by block-matching have superior bone marrow transplant outcome. Human Immunology 61:2, 85-91
CrossRef178
J. Sierra, J. Bjerke, J. Hansen, P. Martin, E. Petersdorf, A. Woolfrey, C. Anasetti. (2000) Marrow Transplants from Unrelated Donors as Treatment for Acute Leukemia. Leukemia & Lymphoma 39:5-6, 495-507
CrossRef179
F. Lozano, M.-T. Arias, J.-M. Vila, I. Gimferrer, L. Places, A. Hummler, G. Ehninger, J. Martorell, J. Vives. (2000) Identification of a novel HLA-Cw*O7 variant (Cw*0714) in a German Caucasian family. Tissue Antigens 55:1, 86-88
CrossRef180
Masahiko MUTO, Makoto ICHIMIYA. (2000) Nishi Nihon Hifuka 62:4, 508-514
CrossRef181
David A Margolis, James T Casper. (2000) Alternative-donor hematopoietic stem-cell transplantation for severe aplastic anemia. Seminars in Hematology 37:1, 43-55
CrossRef182
Neil T. Young. (1999) KIR GENES, KILLER CELLS, AND CLINICAL TRANSPLANTATION. Transplantation 68:11, 1626-1628
CrossRef183
Campbell S. Witt, Christopher Dewing, David C. Sayer, Marcus Uhrberg, Peter Parham, Frank T. Christiansen. (1999) POPULATION FREQUENCIES AND PUTATIVE HAPLOTYPES OF THE KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR SEQUENCES AND EVIDENCE FOR RECOMBINATION1. Transplantation 68:11, 1784-1789
CrossRef184
Eddy Roosnek, Jean-Marie Tiercy. (1999) Search for an unrelated HLA-compatible stem cell donor. Current Opinion in Hematology 6:6, 365
CrossRef185
Effie W Petersdorf, Eric M Mickelson, Claudio Anasetti, Paul J Martin, Ann E Woolfrey, John A Hansen. (1999) Effect of HLA mismatches on the outcome of hematopoietic transplants. Current Opinion in Immunology 11:5, 521-526
CrossRef186
Vinod K. Prasad, Glenn Heller, Nancy A. Kernan, Richard J. O'Reilly, Soo Young Yang. (1999) THE PROBABILITY OF HLA-C MATCHING BETWEEN PATIENT AND UNRELATED DONOR AT THE MOLECULAR LEVEL. Transplantation 68:7, 1044-1050
CrossRef187
T. Juji, Y. Watanabe, Y. Ishikawa, K. Fujiwara, H. Tonami, H. Tanaka, M. Satake, T. Akaza, K. Tadokoro, Y. Kodera, T. Sasazuki, Y. Morishima, F. Takaku. (1999) Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation. Tissue Antigens 54:3, 229-234
CrossRef188
M. Bei, J. Ng, R. Slack, J. Ellis, R.J. Hartzman, C.K. Hurley. (1999) The relative frequencies of HLA-A*10 alleles in five major United States ethnic populations. Tissue Antigens 54:3, 295-299
CrossRef189
Amal Bishara, Chaim Brautbar, Isaac Cohen, Arnon Nagler. (1999) Positivity in a modified mixed leukocyte reaction test correlates with molecular HLA-C disparity in prediction of unrelated bone marrow transplantation outcome. Human Immunology 60:9, 833-839
CrossRef190
Kyung Wha Lee, Soo Young Yang. (1999) HLA-B22 diversity including a novel B54 variant (B
5507) in the Korean population. Human Immunology 60:8, 731-737
CrossRef191
AI GUO WU, MARIA MICHEJDA, AMITABHA MAZUMDER, KENNETH R. MEEHAN, FREDERICK A. MENENDEZ, JEAN-GILLES TCHABO, REBECCA SLACK, MARK P. JOHNSON, JOSEPH A. BELLANTI. (1999) Analysis and Characterization of Hematopoietic Progenitor Cells from Fetal Bone Marrow, Adult Bone Marrow, Peripheral Blood, and Cord Blood. Pediatric Research 46:2, 163-169
CrossRef192
George B Cohen, Rajesh T Gandhi, Daniel M Davis, Ofer Mandelboim, Benjamin K Chen, Jack L Strominger, David Baltimore. (1999) The Selective Downregulation of Class I Major Histocompatibility Complex Proteins by HIV-1 Protects HIV-Infected Cells from NK Cells. Immunity 10:6, 661-671
CrossRef193
E. Carbonnelle, J.C. Poirier, C. Fortier, F. Marzais, C.J.T. Visser, C. Borie, A. Toubert, C. Raffoux, D. Charron, R. Tamouza. (1999) Characterization of a novel HLA-Cw*04 variant in a Laotian family: HLA-Cw*0406. Tissue Antigens 53:6, 601-603
CrossRef194
Carolyn Katovich Hurley, Judith A Wade, Machteld Oudshoorn, Derek Middleton, Debra Kukuruga, Cristina Navarrete, Frank Christiansen, Janet Hegland, Ee-Chee Ren, Irene Andersen, Susan A Cleaver, Chaim Brautbar, Colette Raffoux. (1999) A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors. Human Immunology 60:4, 347-360
CrossRef195
Helen E. Heslop. (1999) HAEMOPOIETIC STEM CELL TRANSPLANTATION FROM UNRELATED DONORS.. British Journal of Haematology 105:1, 2-6
CrossRef196
(1999) Hematopoietic Stem-Cell Transplantation for Acute Leukemia. New England Journal of Medicine 340:10, 809-812
Full Text197
van Rood, Jon J., Oudshoorn, Machteld, . (1998) The Quest for a Bone Marrow Donor — Optimal or Maximal HLA Matching?. New England Journal of Medicine 339:17, 1238-1239
Full Text
- Letters
