Original Article
Axonal Transection in the Lesions of Multiple Sclerosis
N Engl J Med 1998; 338:278-285January 29, 1998
- Abstract
Background
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, most patients have progressive neurologic deterioration that may reflect axonal loss. We conducted pathological studies of brain tissues to define the changes in axons in patients with multiple sclerosis.
Methods
Brain tissue was obtained at autopsy from 11 patients with multiple sclerosis and 4 subjects without brain disease. Fourteen active multiple-sclerosis lesions, 33 chronic active lesions, and samples of normal-appearing white matter were examined for demyelination, inflammation, and axonal pathologic changes by immunohistochemistry and confocal microscopy. Axonal transection, identified by the presence of terminal axonal ovoids, was detected in all 47 lesions and quantified in 18 lesions.
Results
Transected axons were a consistent feature of the lesions of multiple sclerosis, and their frequency was related to the degree of inflammation within the lesion. The number of transected axons per cubic millimeter of tissue averaged 11,236 in active lesions, 3138 at the hypocellular edges of chronic active lesions, 875 in the hypocellular centers of chronic active lesions, and less than 1 in normal-appearing white matter from the control brains.
Conclusions
Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Media in This Article
Figure 3
Confocal Microscopical Images of Axonal Changes in Multiple-Sclerosis Lesions.Figure 1
Serial Sections of Multiple-Sclerosis Lesions Immunostained for Myelin (Panel A), MHC Class II (Panel B), and Nonphosphorylated Neurofilaments (Panel C).Article Activity
- Article
Multiple sclerosis is a disease of the central nervous system characterized by multicentric inflammation and destruction of myelin. The primary cause of multiple sclerosis is unknown. Environmental risk factors1 and multiple genetic loci2-4 contribute to susceptibility to the disease. The onset of the symptoms of multiple sclerosis is often associated with breakdown of the blood–brain barrier, as visualized by magnetic resonance imaging.5,6 Inflammatory mediators block nerve conduction at the nodes of Ranvier,7 and soluble and cellular effector mechanisms destroy myelin.8,9 The intensity of this process, its resolution, and possibly remyelination determine the severity and duration of the clinical symptoms and recovery after each exacerbation. Acute relapses respond well to corticosteroid therapy,10 providing further evidence that inflammation is central to the disease process.
In more than 50 percent of patients with multiple sclerosis, steadily progressive clinical deterioration develops after a 10-to-15-year relapsing–remitting disease course.11 This chronic progressive stage of the disease is much less responsive to antiinflammatory-drug therapy. Although it was formerly assumed that axons were spared from the destructive process, recent studies indicate that axonal injury in multiple sclerosis may cause permanent neurologic dysfunction. Neurologic disability in patients with multiple sclerosis has been correlated with atrophy in the spinal cord,12 cerebellum,13 and cerebral cortex,14 and the neuronal marker N-acetyl aspartate is decreased in multiple-sclerosis lesions according to magnetic resonance spectroscopy.14-17 In patients with relapses, reduced N-acetyl aspartate is restricted to the area of the lesion, whereas patients with chronic progressive multiple sclerosis have reduced N-acetyl aspartate even in normal-appearing white matter.18 This observation suggests the spread of axonal pathologic changes, wallerian degeneration, or both.19,20
Axonal pathologic changes in multiple sclerosis were mentioned by Charcot21 and have been reported in an experimental model of immune-mediated demyelination.22 Few studies have rigorously characterized axonal pathologic changes in the brains of patients with multiple sclerosis. A recent study reported axonal accumulation of the amyloid precursor protein in multiple-sclerosis lesions and raised the possibility of irreversible axonal damage.23 Using three-dimensional imaging of brain sections, we have attempted to identify the pathologic changes in axons in multiple sclerosis.
Methods
Tissue
We studied tissue from the brains of 11 patients with multiple sclerosis (age at death, 18 to 62 years; 8 women and 3 men). Forty-seven demyelinated lesions were identified, and each was characterized as active or chronic active, as described previously.24 Active lesions contained abundant and evenly distributed major-histocompatibility-complex (MHC) class II–positive cells throughout the lesion and myelin-protein–positive inclusions within the macrophages. In chronic active lesions, MHC class II–positive cells were abundant at the edges of lesions and less frequent in the center. On the basis of these criteria, 14 active and 33 chronic active lesions were identified.
Immunocytochemistry
The tissue was fixed in 4 percent paraformaldehyde, protected in 70 percent sucrose, placed on the stage of a sliding microtome, and frozen. Free-floating sections (30 μm thick) were cut without exposure to solvents or other embedding mediums. Sections were rinsed in phosphate-buffered saline four times for 5 minutes each, microwaved twice for 5 minutes each in 10 mM citrate buffer (pH 6.0), incubated in 3 percent hydrogen peroxide and 10 percent Triton X-100 for 30 minutes, and immunostained by the avidin–biotin complex procedure and with diaminobenzidine, as described previously.24 Sections for confocal microscopy were pretreated as described above, incubated with two primary antibodies, and then incubated with fluorescein-conjugated and Texas red–conjugated secondary antibodies (Jackson Laboratories, West Grove, Pa.), as described previously.25
Antibodies
The following well-characterized primary antibodies were used: mouse anti–MHC class II and rabbit anti–myelin basic protein (Dako, Carpinteria, Calif.), mouse anti–proteolipid protein (gift from Nigel Groom), rabbit antiferritin (Sigma Immunochemicals, St. Louis), and mouse anti–nonphosphorylated neurofilament (SMI-32) (Sternberger Monoclonals, Baltimore).
Confocal Microscopy
Sections were analyzed on a Leica Aristoplan laser scanning microscope (Leitz Wetzlar, Heidelberg, Germany). Individual confocal optical sections represented 0.5-μm axial resolution. The entire thickness of the section was scanned. The images presented here consist of 16 to 32 optical sections combined to form a “through-focus” image. Fluorescence was collected individually in the green (fluorescein) and red (Texas red) channels to eliminate “bleed-through” from either channel. The yellow is a result of stacking multiple images and not of colocalization of antigens.
Quantification of Terminal Swellings
Tissue from five brains, which included 5 active and 13 chronic active lesions, was selected for quantitative analysis of axonal transection. Sections immunostained with nonphosphorylated-neurofilament antibodies and diaminobenzidine were used for quantification. Only swellings at the terminal ends of axons, as verified by moving the plane of focus up and down through the section, were counted. To eliminate regional variations in the distribution of terminal-axon ovoids, all areas of multiple-sclerosis lesions were analyzed. The tissue volume (in cubic millimeters) was calculated by multiplying the total two-dimensional area of the grid that was analyzed by the thickness of the section (30 μm). Terminal ovoids in multiple-sclerosis lesions, 10 microscopical fields of normal-appearing white matter in multiple-sclerosis blocks, and 20 microscopical fields of white matter from control brains were quantified. The data were compared by the Wilcoxon rank-sum test and mixed-model analysis.
Results
Axonal Pathologic Changes in Multiple-Sclerosis Lesions
Axonal pathologic changes, demyelination, and inflammation were studied in serial sections of individual multiple-sclerosis lesions immunostained with antibodies to proteolipid protein, MHC class II molecules, and nonphosphorylated neurofilament (SMI-32) (Figure 1AFigure 1
Serial Sections of Multiple-Sclerosis Lesions Immunostained for Myelin (Panel A), MHC Class II (Panel B), and Nonphosphorylated Neurofilaments (Panel C)., Figure 1B, and Figure 1C). Proteolipid protein is the major structural protein of central nervous system myelin,26 and its absence in white matter indicates areas of demyelination. MHC class II molecules are expressed by activated monocytes and microglia concentrated in and around multiple-sclerosis lesions,24 and their abundance and distribution have been used to characterize different stages of demyelinating lesions.23,27,28 Nonphosphorylated neurofilaments are abundant in neuronal cell bodies and dendrites.29-31 Neurofilaments in healthy myelinated axons are heavily phosphorylated and not stained by SMI-32 antibodies.29 SMI-32 immunoreactivity in normally myelinated regions of the brain provides a sensitive marker for demyelination or axonal pathologic changes. SMI-32 immunoreactivity was rare in normal-appearing white matter from control brains (data not shown). In contrast, all 47 multiple-sclerosis lesions analyzed contained abundant SMI-32–positive axons.Figure 1A, Figure 1B, and Figure 1C shows a lesion classified as active because of the absence of proteolipid-protein immunoreactivity (Panel A) and the abundance and even distribution of MHC class II–positive cells (Panel B) throughout the demyelinated area. The acuteness of the demyelination is also indicated by the detection of proteolipid-protein–positive myelin debris within the lesion (Figure 1A, arrowheads). Abundant SMI-32 immunoreactivity was detected within the area of demyelination (Figure 1C). This staining appeared as thin lines and small dots, which represent demyelinated axons viewed in longitudinal and transverse orientation, and as larger ovoids that may represent damaged axons.
Several patterns of SMI-32 staining were detected in and near multiple-sclerosis lesions, and these patterns varied on the basis of lesion activity. In active lesions, small-diameter axons and large ovoids (Figure 2AFigure 2
Patterns of Axonal Pathologic Changes in Multiple-Sclerosis Lesions.) were distributed randomly throughout the demyelinated area. In chronic active lesions, SMI-32–positive axons and ovoids were concentrated at the actively demyelinating edges (Figure 2B). Both were less abundant than those found in active lesions, and the ovoids were of smaller diameter. The centers of chronic active lesions contained fewer SMI-32–positive axons and ovoids than the borders (data not shown).Individual axons displayed several patterns of SMI-32 immunoreactivity. Most abundant were continuous lines of SMI-32 immunoreactivity (Figure 2A and Figure 2B), which indicated intact demyelinated axons. Some axons contained discontinuous lines of SMI-32–positive dots (Figure 2C). These staining patterns are consistent with axonal degeneration distal to the sites of transection. Other axons showed dramatic changes in caliber, including alternating constrictions and dilatations or single swellings that extended from a thin axon (Figure 2D).
Axonal Transection in Multiple-Sclerosis Lesions
The most striking axonal alterations in multiple-sclerosis lesions were ovoids of intense SMI-32 staining. These structures resembled terminal axonal ovoids or end bulbs that resulted from axon transection.32-35 To confirm this interpretation, sections were stained with SMI-32 and fluorescence-labeled antibodies and examined by confocal microscopy, and computer-based three-dimensional reconstructions of entire ovoids were generated. Figure 3AFigure 3
Confocal Microscopical Images of Axonal Changes in Multiple-Sclerosis Lesions. shows an active lesion with many axonal ovoids. On the basis of three-dimensional analysis, the vast majority of ovoids retained only a single axonal connection (Figure 3A, arrows). Axonal ovoids with dual axonal connections were rare (Figure 3A, arrowhead). This analysis established that the majority of SMI-32–positive axonal swellings were terminal ends of axons.Axonal Transection in Relation to Demyelinating Activity in Multiple-Sclerosis Lesions
Inflammatory demyelination is the pathologic hallmark of multiple sclerosis. The relation between SMI-32–positive terminal ovoids and active demyelination was studied by confocal microscopy. Figure 3B shows the distribution of SMI-32 (green) and myelin basic protein (red) at the edge of a chronic active lesion. Three large-diameter axons are intensely stained by SMI-32 antibodies. The irregular and discontinuous distribution of myelin basic protein immunoreactivity around these axons indicates ongoing demyelination. The two lower, large-diameter fibers had normal-appearing axonal cylinders, whereas the upper fiber terminated in a large ovoid (Figure 3B, arrow). Figure 3C is another confocal image of myelin basic protein (red) and SMI-32 (green) staining at the border of a lesion. Many SMI-32–positive, myelin basic protein–negative fibers extended into normal-appearing white matter, where they remained SMI-32–positive but were surrounded by normal-appearing myelin internodes (Figure 3C, arrowheads). Occasionally, an SMI-32–positive axon that was surrounded by normal-appearing myelin terminated in a swelling (Figure 3C, arrow). Confocal analysis of these and similar fibers provided additional evidence that most SMI-32–positive ovoids were terminal ends of axons.
Cells of monocyte origin are effectors in tissue destruction and phagocytosis in multiple-sclerosis lesions. To study the association between macrophages or microglia and terminal axonal ovoids, sections were immunostained for SMI-32 and ferritin (a marker for cells of monocyte origin) and analyzed by confocal microscopy. In the center of an active lesion (Figure 3D), phagocytic macrophages were abundant and were closely associated with or partially surrounded terminal axonal ovoids (Figure 3D, arrows). Normal-appearing SMI-32–positive axons (Figure 3D, arrowheads) were not surrounded by phagocytic macrophages. At the borders of chronic active lesions (Figure 3E), the majority of ferritin-positive cells (red) were process-bearing microglia. SMI-32–positive axons (green) were abundant; most had a normal appearance and no consistent association with activated microglia (Figure 3E, arrowheads). However, two terminal axonal swellings were engulfed by activated microglia (Figure 3E, large arrows), whereas a swelling with dual axonal connections was not ensheathed by microglia or their processes (Figure 3E, small arrow).
Quantification of Axonal Transection
The results described above established a strong qualitative correlation between axonal pathologic changes and areas of demyelination in 47 lesions from 11 patients with multiple sclerosis. To determine the quantitative relation between axonal transection and regions of demyelination and inflammation, we counted the number of SMI-32–positive terminal axonal swellings in 5 active and 13 chronic active lesions selected from five well-preserved brains of patients with multiple sclerosis. Transected axons within chronic active lesions were counted in the cores and at the edges of the lesions. The clinical features of the five patients are shown in Table 1Table 1
Clinical Features of Patients with Multiple Sclerosis Whose Brain Tissue Was Used for Quantitative Studies.. One had acute progressive disease with a course of only 2 weeks; another had primary progressive disease with a 5-year course; and three had secondary progressive disease with durations ranging from 7 to 27 years.The average number of SMI-32–positive terminal ovoids per cubic millimeter of tissue was 17 in 11 areas of normal-appearing white matter from brains of patients with multiple sclerosis and less than 1 in 5 blocks from four control brains (Table 2Table 2
Distribution and Number of Transected Axons in Multiple-Sclerosis Lesions.). The average number of terminal axonal ovoids per cubic millimeter of tissue was 11,236 in active lesions, 3138 in the demyelinating borders of chronic active lesions, and 875 in their inactive centers. All multiple-sclerosis lesions contained significantly more terminal axonal ovoids than did normal control tissue. Active lesions contained significantly more terminal ovoids than the edges or cores of chronic active lesions, and terminal ovoids were significantly more numerous at the edges of chronic active lesions than in their cores. All lesion areas contained significantly more terminal ovoids than nonlesion areas in sections of brains of patients with multiple sclerosis. These results establish that axonal transection is a consistent and abundant feature of multiple-sclerosis lesions and that its incidence is related to the degree of inflammation.Discussion
These results establish that axonal transection is a consistent consequence of demyelination in the brains of patients with multiple sclerosis. The use of 30-μm-thick sections and computer-based three-dimensional reconstruction identified the vast majority of axonal ovoids as terminal ends of axons. The number of terminal axonal ovoids per cubic millimeter of tissue averaged 11,236 in active lesions, 3138 at the edges of chronic active lesions, 875 at the centers of chronic active lesions, and less than 1 in white matter from control brains. These results are consistent with and extend those of a recent report describing amyloid precursor protein–positive axonal swellings in 10-μm-thick paraffin sections of multiple-sclerosis lesions.23 Since many multiple-sclerosis lesions have volumes of several cubic centimeters, these data establish axons as a major disease target in patients with multiple sclerosis.
The finding of extensive axonal transection in multiple-sclerosis lesions has important clinical and therapeutic implications. Historically, it has been assumed that the disease process in multiple sclerosis spares axons. Major therapeutic and research efforts have been directed toward limiting immune-mediated damage to myelin and promoting remyelination. The treatment of multiple sclerosis remains unsatisfactory, with chronic disease progression being the principal clinical challenge. This report and recent results from magnetic resonance imaging studies indicate a need for noninvasive techniques that monitor axonal pathologic changes in patients with multiple sclerosis. The development of neuroprotective therapies should become an objective of multiple-sclerosis research. It will be of particular interest to define the consequences in terms of axonal injury of therapy with high-dose pulsed corticosteroids, commonly used to treat relapses,10 and interferon beta, which is indicated for patients with relapsing–remitting disease.36,37
The findings in this study provide an additional rationale for early treatment with drugs that reduce inflammation, since axonal transection is irreversible and is most abundant in areas of inflammation. However, the effects of specific antiinflammatory strategies on axonal integrity will need careful evaluation. Ultimately, neuroprotective factors may be one element of an effective, comprehensive therapeutic strategy for multiple sclerosis.
Axonal transection was abundant in active and chronic active lesions from patients with durations of clinical disease ranging from 2 weeks to 27 years. During relapsing–remitting stages of the disease, the restoration of conduction along demyelinated axons, redundant neuronal pathways, or axonal sprouting may compensate for the destruction of axons. Our results suggest that a threshold of axonal loss is eventually reached beyond which patients have progressive neurologic deterioration. If axonal pathologic changes begin at the onset of disease, as our data suggest, aggressive early treatment with neuroprotective agents should be considered.
Axonal destruction in multiple-sclerosis lesions could result from direct immunologic attack on axons, from soluble inflammatory mediators, or from secondary effects of chronic demyelination. A specific immune attack on axons seems unlikely, because most axons survive the demyelinating process and have no consistent association with cells of monocytic origin. Since the greatest degree of axonal transection occurred in areas of active demyelination and inflammation, we consider it most likely that demyelinated axons are vulnerable to inflammatory environments and that axonal transection is caused by proteolytic enzymes, cytokines, oxidative products, and free radicals produced by activated immune and glial cells.38-40
The possibility that chronic demyelination may lead to axonal degeneration was also supported by the finding of terminal axonal ovoids in the centers of chronic active lesions. Myelination provides an extrinsic trophic signal to axons that increases axonal caliber,41,42 and the loss of this effect can result in axonal degeneration. Although the precise nature of this trophic effect is unknown, degeneration and atrophy have been described in mouse axons that are normally myelinated but are deficient in the myelin-associated glycoprotein.43 As a member of the immunoglobulin gene superfamily that is localized exclusively in the adaxonal membrane of central nervous system myelin,44 myelin-associated glycoprotein may directly or indirectly be part of a ligand system that modulates the maturation and survival of myelinated axons.
Neurofilaments are the principal constituent of the axonal cytoskeleton,45 and their phosphorylation states are dynamically regulated by myelination, demyelination, and intrinsic axonal pathologic changes. Developmentally, myelination increases neurofilament phosphorylation, which in turn increases the lateral extension of neurofilament side arms.46,47 This increases neurofilament spacing, axonal caliber, and axonal conduction velocity.42,48 In animal models, demyelination or dysmyelination causes decreased neurofilament phosphorylation, reduced axonal caliber, and an increase in nonphosphorylated neurofilament epitopes.49,50 Therefore, it was expected that SMI-32 immunoreactivity would be increased in multiple-sclerosis lesions and that most SMI-32–positive axons would appear normal. In addition to axonal transection, two patterns of axonal pathologic changes were identified. Discontinuous SMI-32 staining similar to that described in axonal degeneration (Figure 2C) provided additional evidence of axonal transection in multiple-sclerosis lesions. Other axons had significant alterations in caliber (Figure 2D) and represented damaged axons that retained active-transport systems and connection to neuronal perikarya.
Axons distant from multiple-sclerosis lesions also displayed alterations in neurofilament phosphorylation. Although most appeared normally myelinated, some ended in terminal ovoids. This finding is consistent with the results of magnetic resonance spectroscopy studies that detected reduced N-acetyl aspartate in regions where there were no visible lesions.20 Reduced N-acetyl aspartate may therefore reflect potentially reversible axonal dysfunction due to demyelination,51 as well as irreversible axonal degeneration distal to sites of transection. Since myelin ensheathment governs the activity of the axonal kinases and phosphatases that regulate neurofilament phosphorylation, myelination may also modulate the activity of aspartoacylase, the enzyme that hydrolyzes N-acetyl aspartate to aspartate and acetate. N-Acetyl aspartate–derived acetate can be used to make acetyl coenzyme A.52 N-Acetyl aspartate may therefore be part of an energy-storage system in axons that helps meet the energy demands of saltatory conduction. In the absence of myelination, axonal energy demands may be reduced and N-acetyl aspartate levels diminished. The results of this study highlight the considerable importance of clarifying the implications of reduced N-acetyl aspartate in multiple-sclerosis lesions, and they stress the need to develop or improve noninvasive methods of monitoring and treating axonal pathologic changes in patients with multiple sclerosis.
Supported by a grant from the National Institutes of Health (R01 NS35058), the Norwegian Research Council, the Multiple Sclerosis Society of Norway, and the Rebekka Ege Hegermann Foundation, Bergen, Norway.
We are indebted to Karen Toil for typing the manuscript and to Jeff Cohen for helpful comments.
Source Information
From the Departments of Neurosciences (B.D.T., J.P., R.M.R., R.R., L.B.) and Neurology (R.M.R., R.R.), Lerner Research Institute, and the Mellen Center for Multiple Sclerosis Research (R.M.R., R.R.), Cleveland Clinic Foundation, Cleveland; and the Department of Pathology, Haukeland Hospital, Bergen, Norway (S.M.).
Address reprint requests to Dr. Trapp at the Department of Neurosciences, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195.
- References
References
1
Weinshenker BG . Epidemiology of multiple sclerosis. Neurol Clin 1996;14:291-308
CrossRef | Web of Science | Medline2
Sawcer S ,Jones HB ,Feakes R , et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 1996;13:464-468
CrossRef | Web of Science | Medline3
Haines JL ,Ter-Minassian M ,Bazyk A , et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex: the Multiple Sclerosis Genetics Group. Nat Genet 1996;13:469-471
CrossRef | Web of Science | Medline4
Ebers GC ,Kukay K ,Bulman DE , et al. A full genome search in multiple sclerosis. Nat Genet 1996;13:472-476
CrossRef | Web of Science | Medline5
McFarland HF ,Frank JA ,Albert PS , et al. Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 1992;32:758-766
CrossRef | Web of Science | Medline6
Rudick RA ,Cookfair D ,Ransohoff R , et al. Cerebrospinal fluid abnormalities in a phase III trial interferon beta-1a (Avonex) for relapsing multiple sclerosis. Ann Neurol 1996;40:516-516 abstract.7
Bornstein MB ,Crain SM . Functional studies of cultured human brain tissues as related to “demyelinative disorders.“ Science 1965;148:1242-1244
CrossRef | Web of Science | Medline8
Prineas JW ,Graham JS . Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 1981;10:149-158
CrossRef | Web of Science | Medline9
Prineas JW ,Kwon EE ,Cho ES ,Sharer LR . Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques. Ann N Y Acad Sci 1984;436:11-32
CrossRef | Web of Science | Medline10
Milligan NM ,Newcombe R ,Compston DAS . A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis. I. Clinical effects. J Neurol Neurosurg Psychiatry 1987;50:511-516
CrossRef | Web of Science | Medline11
Weinshenker BG ,Bass B ,Rice GP , et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112:133-146
CrossRef | Web of Science | Medline12
Losseff NA ,Webb SL ,O'Riordan JI , et al. Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996;119:701-708
CrossRef | Web of Science | Medline13
Davie CA ,Barker GJ ,Webb S , et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995;118:1583-1592
CrossRef | Web of Science | Medline14
Losseff NA ,Wang L ,Lai HM , et al. Progressive cerebral atrophy in multiple sclerosis: a serial MRI study. Brain 1996;119:2009-2019
CrossRef | Web of Science | Medline15
Arnold DL ,Riess GT ,Matthews PM , et al. Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 1994;36:76-82
CrossRef | Web of Science | Medline16
Davie CA ,Hawkins CP ,Barker GJ , et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58
CrossRef | Web of Science | Medline17
De Stefano N ,Matthews PM ,Antel JP ,Preul M ,Francis G ,Arnold DL . Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995;38:901-909
CrossRef | Web of Science | Medline18
Matthews PM ,Pioro E ,Narayanan S , et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 1996;119:715-722
CrossRef | Web of Science | Medline19
McDonald WI . Rachelle Fishman-Matthew Moore Lecture: the pathological and clinical dynamics of multiple sclerosis. J Neuropathol Exp Neurol 1994;53:338-343
CrossRef | Web of Science | Medline20
Narayanan S ,Fu L ,Pioro E , et al. Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions. Ann Neurol 1997;41:385-391
CrossRef | Web of Science | Medline21
Charcot M . Histologie de la sclerose en plaques. Gaz Hosp 1868;141:554-5, 55722
Raine CS ,Cross AH . Axonal dystrophy as a consequence of long-term demyelination. Lab Invest 1989;60:714-725
Web of Science | Medline23
Ferguson B ,Matyszak MK ,Esiri MM ,Perry VH . Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393-399
CrossRef | Web of Science | Medline24
Bo L ,Mork S ,Kong PA ,Nyland H ,Pardo CA ,Trapp BD . Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol 1994;51:135-146
CrossRef | Web of Science | Medline25
Trapp BD, Nishiyama A, Cheng D, Macklin W. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain.J Cell Biol 1997;137:459-68.
26
Norton WT ,Poduslo SE . Myelination in rat brain: method of myelin isolation. J Neurochem 1973;21:749-757
CrossRef | Web of Science | Medline27
Prineas JW. The neuropathology of multiple sclerosis: In: Koetsier JC, ed. Demyelinating diseases. Vol. 47 of Handbook of clinical neurology. Amsterdam: Elsevier Science, 1985:213-57.
28
Bo L ,Peterson JW ,Mork S , et al. Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the β2 integrin LFA-1 in multiple sclerosis lesions. J Neuropathol Exp Neurol 1996;55:1060-1072
Web of Science | Medline29
Sternberger LA ,Sternberger NH . Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci U S A 1983;80:6126-6130
CrossRef | Web of Science | Medline30
Lee VM-Y ,Carden MJ ,Trojanowski JQ . Novel monoclonal antibodies provide evidence for the in situ existence of a nonphosphorylated form of the largest neurofilament subunit. J Neurosci 1986;6:850-858
Web of Science | Medline31
Lee VM ,Carden MJ ,Schlaepfer WW ,Trojanowski JQ . Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J Neurosci 1987;7:3474-3488
Web of Science | Medline32
Cochran E ,Bacci B ,Chen Y ,Patton A ,Gambetti P ,Autilio-Gambetti L . Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease. Am J Pathol 1991;139:485-489
Web of Science | Medline33
Gentleman SM ,Nash MJ ,Sweeting CJ ,Graham DI ,Roberts GW . Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury. Neurosci Lett 1993;160:139-144
CrossRef | Web of Science | Medline34
Ohgami T ,Kitamoto T ,Tateishi J . Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions. Neurosci Lett 1992;136:75-78
CrossRef | Web of Science | Medline35
Sherriff FE ,Bridges LR ,Gentleman SM ,Sivaloganathan S ,Wilson S . Markers of axonal injury in post mortem human brain. Acta Neuropathol (Berl) 1994;88:433-439
CrossRef | Web of Science | Medline36
IFNB Multiple Sclerosis Study Group, University of British Columbia MS/MRI Analysis Group
Web of Science | Medline37
Jacobs LD ,Cookfair DL ,Rudick RA , et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 1996;39:285-294
CrossRef | Web of Science | Medline38
Selmaj K ,Raine CS ,Cannella B ,Brosnan CF . Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991;87:949-954
CrossRef | Web of Science | Medline39
Bo L ,Dawson TM ,Wesselingh S , et al. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 1994;36:778-786
CrossRef | Web of Science | Medline40
Hohlfeld R . Biotechnological agents for the immunotherapy of multiple sclerosis: principles, problems and perspectives. Brain 1997;120:865-916
CrossRef | Web of Science | Medline41
Windebank AJ ,Wood P ,Bunge RP ,Dyck PJ . Myelination determines the caliber of dorsal root ganglion neurons in culture. J Neurosci 1985;5:1563-1569
Web of Science | Medline42
Sanchez I ,Hassinger L ,Paskevich PA ,Shine HD ,Nixon RA . Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J Neurosci 1996;16:5095-5105
Web of Science | Medline43
Fruttiger M ,Montag D ,Schachner M ,Martini R . Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 1995;7:511-515
CrossRef | Web of Science | Medline44
Trapp BD ,Andrews SB ,Cootauco C ,Quarles RH . The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J Cell Biol 1989;109:2417-2426
CrossRef | Web of Science | Medline45
Hoffman PN ,Lasek RJ . The slow component of axonal transport: identification of major structural polypeptides of the axon and their generality among mammalian neurons. J Cell Biol 1975;66:351-366
CrossRef | Web of Science | Medline46
Hirokawa N ,Glicksman MA ,Willard MB . Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton. J Cell Biol 1984;98:1523-1536
CrossRef | Web of Science | Medline47
Nakagawa T ,Chen J ,Zhang Z ,Kanai Y ,Hirokawa N . Two distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filaments. J Cell Biol 1995;129:411-429
CrossRef | Web of Science | Medline48
Arbuthnott ER ,Boyd IA ,Kalu KU . Ultrastructural dimensions of myelinated peripheral nerve fibers in the cat and their relation to conduction velocity. J Physiol (Lond) 1980;308:125-15749
deWaegh SM ,Lee VM-Y ,Brady ST . Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 1992;68:451-463
CrossRef | Web of Science | Medline50
Hsieh S-T ,Crawford TO ,Bouldin TW ,Griffin JW . Influence of demyelination and remyelination on axonal organization. Brain Pathol 1993;3:307-307
CrossRef51
De Stefano N ,Matthews PM ,Arnold DL . Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 1995;34:721-727
CrossRef | Web of Science | Medline52
Mehta V ,Namboodiri MAA . N-acetylaspartate as an acetyl source in the nervous system. Brain Res Mol Brain Res 1995;31:151-157
CrossRef | Medline
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Janusz J. Jadasz, Ludwig Aigner, Francisco J. Rivera, Patrick Küry. (2012) The remyelination Philosopher's Stone: stem and progenitor cell therapies for multiple sclerosis. Cell and Tissue Research
CrossRef2
Andrew L. Alexander, Samuel A. Hurley, Alexey A. Samsonov, Nagesh Adluru, Ameer Pasha Hosseinbor, Pouria Mossahebi, Do P.M. Tromp, Elizabeth Zakszewski, Aaron S. Field. (2012) Characterization of Cerebral White Matter Properties Using Quantitative Magnetic Resonance Imaging Stains. Brain Connectivity120127080955001
CrossRef3
R. A. Farrell, M. Marta, A. J. Gaeguta, V. Souslova, G. Giovannoni, P. I. Creeke. (2012) Development of resistance to biologic therapies with reference to IFN- : Understanding drug resistance to biological therapy. Rheumatology
CrossRef4
Melissa Cambron, Miguel D'Haeseleer, Guy Laureys, Ralph Clinckers, Jan Debruyne, Jacques De Keyser. (2012) White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis. Journal of Cerebral Blood Flow & Metabolism
CrossRef5
Eoin Mulroy, Emer Joyce, Jaqueline Scott, Jane Melling, Carole Goggin, Niall Mahon, Killian O’Rourke, Timothy Lynch. (2012) Long-Term Risk of Leukaemia or Cardiomyopathy after Mitoxantrone Therapy for Multiple Sclerosis. European Neurology 67:1, 45-47
CrossRef6
Ladislav Ouda, Rastislav Druga, Josef Syka. (2012) Distribution of SMI-32-immunoreactive neurons in the central auditory system of the rat. Brain Structure and Function 217:1, 19-36
CrossRef7
William E. Wu, Achim Gass, Lidia Glodzik, James S. Babb, Jochen Hirsch, Marc Sollberger, Lutz Achtnichts, Michael Amann, Andreas U. Monsch, Oded Gonen. (2012) Whole brain N-acetylaspartate concentration is conserved throughout normal aging. Neurobiology of Aging
CrossRef8
Mathew Foster, Robert Zivadinov, Bianca Weinstock-Guttman, Miriam Tamaño-Blanco, Darlene Badgett, Ellen Carl, Murali Ramanathan. (2012) Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis. Journal of Neuroimmunology
CrossRef9
Helena Batoulis, Martin Uhl, Klaus Addicks, Paul V. Lehmann, Stefanie Kuerten. (2012) The magnitude of the antigen-specific T cell response is separated from the severity of spinal cord histopathology in remitting-relapsing experimental autoimmune encephalomyelitis. Glian/a-n/a
CrossRef10
John N. Ratchford, Christopher J. Endres, Dima A. Hammoud, Martin G. Pomper, Navid Shiee, John McGready, Dzung L. Pham, Peter A. Calabresi. (2011) Decreased microglial activation in MS patients treated with glatiramer acetate. Journal of Neurology
CrossRef11
Lorenzo Testaverde, Laura Caporali, Eugenio Venditti, Giovanni Grillea, Claudio Colonnese. (2011) Diffusion tensor imaging applications in multiple sclerosis patients using 3T magnetic resonance: a preliminary study. European Radiology
CrossRef12
Reiko E. Sakai, Daniel J. Feller, Kristin M. Galetta, Steven L. Galetta, Laura J. Balcer. (2011) Vision in Multiple Sclerosis. Journal of Neuro-Ophthalmology 31:4, 362-373
CrossRef13
Pietro Iaffaldano, Guglielmo Lucchese, Maria Trojano. (2011) Treating multiple sclerosis with natalizumab. Expert Review of Neurotherapeutics 11:12, 1683-1692
CrossRef14
Jian-Ping Xu, Jie Zhao, Shao Li. (2011) Roles of NG2 glial cells in diseases of the central nervous system. Neuroscience Bulletin 27:6, 413-421
CrossRef15
Joseph M. Antony. (2011) The cellular prion protein in multiple sclerosis: A potential target for neurotherapeutics?. Translational Neuroscience 2:4, 351-359
CrossRef16
Irina Elovaara. (2011) Early treatment in multiple sclerosis. Journal of the Neurological Sciences 311, S24-S28
CrossRef17
V. Millet, M. Marder, L.A. Pasquini. (2011) Adult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination. Experimental Neurology
CrossRef18
Ulf Ziemann, Mathias Wahl, Elke Hattingen, Hayrettin Tumani. (2011) Development of biomarkers for multiple sclerosis as a neurodegenerative disorder. Progress in Neurobiology 95:4, 670-685
CrossRef19
Smita Zaheer, Yanghong Wu, Xi Yang, Marcus Ahrens, Shailendra K. Sahu, Asgar Zaheer. (2011) Clinical course of myelin oligodendrocyte glycoprotein 35–55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor. Neurochemistry International
CrossRef20
Sarah Lutz, Cedric Raine, Celia Brosnan. 2011. Astrocyte Involvement in the Acquired Demyelinating Diseases. , 283-310.
CrossRef21
Thomas J. Covey, Robert Zivadinov, Janet L. Shucard, David W. Shucard. (2011) Information processing speed, neural efficiency, and working memory performance in multiple sclerosis: Differential relationships with structural magnetic resonance imaging. Journal of Clinical and Experimental Neuropsychology1-17
CrossRef22
Travis Musgrave, Camille J Olechowski, Bradley J Kerr. (2011) Learning new tricks from an old dog: using experimental autoimmune encephalomyelitis to study comorbid symptoms in multiple sclerosis. Pain Management 1:6, 571-576
CrossRef23
Rachel Williams, Cassandra L. Buchheit, Nancy E. J. Berman, Steven M. LeVine. (2011) Pathogenic implications of iron accumulation in multiple sclerosis. Journal of Neurochemistryno-no
CrossRef24
Natalia M. Moll, Anna M. Rietsch, Smitha Thomas, Amy J. Ransohoff, Jar-Chi Lee, Robert Fox, Ansi Chang, Richard M. Ransohoff, Elizabeth Fisher. (2011) Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations. Annals of Neurology 70:5, 764-773
CrossRef25
Catherine Fressinaud, Raphaël Berges, Joël Eyer. (2011) Axon cytoskeleton proteins specifically modulate oligodendrocyte growth and differentiation in vitro. Neurochemistry International
CrossRef26
Ryan R. Williams, Damien D. Pearse, Patrick A. Tresco, Mary B. Bunge. (2011) The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration. The Journal of Gene Medicinen/a-n/a
CrossRef27
Eugenio Pucci, Giorgio Giuliani, Alessandra Solari, Silvana Simi, Silvia Minozzi, Carlo Di Pietrantonj, Ian Galea, Eugenio Pucci. 2011. Natalizumab for relapsing remitting multiple sclerosis. .
CrossRef28
Yolanda S. Kap, Jan Bauer, Nikki van Driel, Wim K. Bleeker, Paul W.H.I. Parren, Evert-Jan Kooi, Jeroen J.G. Geurts, Jon D. Laman, Jenny L. Craigen, Erwin Blezer, Bert A. 't Hart. (2011) B-Cell Depletion Attenuates White and Gray Matter Pathology in Marmoset Experimental Autoimmune Encephalomyelitis. Journal of Neuropathology and Experimental Neurology1
CrossRef29
E. Rodríguez de Mingo, N. Martín Peña. (2011) «Mareo» como primera manifestación de una esclerosis múltiple primariamente progresiva. SEMERGEN - Medicina de Familia
CrossRef30
A. Bethune, V. Tipu, J.G. Sled, S. Narayanan, D.L. Arnold, D. Mabbott, C. Rockel, R. Ghassemi, C. Till, B. Banwell. (2011) Diffusion tensor imaging and cognitive speed in children with multiple sclerosis. Journal of the Neurological Sciences 309:1-2, 68-74
CrossRef31
Mihaela Kreutzer, Frauke Seehusen, Robert Kreutzer, Kidsadagorn Pringproa, Maren Kummerfeld, Peter Claus, Ulrich Deschl, Arno Kalkul, Andreas Beineke, Wolfgang Baumgärtner, Reiner Ulrich. (2011) Axonopathy is associated with complex axonal transport defects in a model of multiple sclerosis. Brain Pathologyno-no
CrossRef32
Li Endong, Jin Shijie, Yoshifumi Sonobe, Ma Di, Li Hua, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumura. (2011) The Gap-junction inhibitor Carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. Journal of Neuroimmunology
CrossRef33
Khader M. Hasan, Indika S. Walimuni, Humaira Abid, Sushmita Datta, Jerry S. Wolinsky, Ponnada A. Narayana. (2011) Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: Implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS. Journal of the Neurological Sciences
CrossRef34
Stefanie Kuerten, Paul V. Lehmann. (2011) The Immune Pathogenesis of Experimental Autoimmune Encephalomyelitis: Lessons Learned for Multiple Sclerosis?. Journal of Interferon & Cytokine Research110921064817007
CrossRef35
Tamir Ben-Hur. (2011) Cell Therapy for Multiple Sclerosis. Neurotherapeutics
CrossRef36
Christina Gavino, Stéphane Richard. (2011) Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival. Scientific Reports 1,
CrossRef37
R. Brambilla, J. J. Ashbaugh, R. Magliozzi, A. Dellarole, S. Karmally, D. E. Szymkowski, J. R. Bethea. (2011) Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination. Brain 134:9, 2736-2754
CrossRef38
Adam C. Vana, Shihe Li, Rachel Ribeiro, Flaubert Tchantchou, Yumin Zhang. (2011) Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter. Experimental Neurology 231:1, 45-55
CrossRef39
A. Petzold, D.J. Tozer, K. Schmierer. (2011) Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter. Experimental Neurology
CrossRef40
Robert P. Lisak, Liljana Nedelkoska, Diane Studzinski, Beverly Bealmear, Wenbo Xu, Joyce A. Benjamins. (2011) Cytokines regulate neuronal gene expression: Differential effects of Th1, Th2 and monocyte/macrophage cytokines. Journal of Neuroimmunology 238:1-2, 19-33
CrossRef41
Evert-Jan Kooi, Marloes Prins, Natasha Bajic, Jeroen A. M. Beliën, Wouter H. Gerritsen, Jack Horssen, Eleonora Aronica, Anne-Marie Dam, Jeroen J. M. Hoozemans, Paul T. Francis, Paul Valk, Jeroen J. G. Geurts. (2011) Cholinergic imbalance in the multiple sclerosis hippocampus. Acta Neuropathologica 122:3, 313-322
CrossRef42
Lucinda Aguirre-Cruz, José Flores-Rivera, Dora Luz De La Cruz-Aguilera, Edgar Rangel-López, Teresa Corona. (2011) Multiple sclerosis in Caucasians and Latino Americans. Autoimmunity110830012942000
CrossRef43
T. Hayton, J. Furby, K. J. Smith, D. R. Altmann, R. Brenner, J. Chataway, K. Hunter, D. J. Tozer, D. H. Miller, R. Kapoor. (2011) Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis. Journal of Neurology
CrossRef44
Minesh Kapadia, Boris Sakic. (2011) Autoimmune and inflammatory mechanisms of CNS damage. Progress in Neurobiology
CrossRef45
R. Gold, J. S. Wolinsky. (2011) Pathophysiology of multiple sclerosis and the place of teriflunomide. Acta Neurologica Scandinavica 124:2, 75-84
CrossRef46
F. Zipp, R. Gold. (2011) Neuroprotektion in der Therapie der Multiplen Sklerose. Der Nervenarzt 82:8, 973-977
CrossRef47
M. Mäurer, R. Dachsel, S. Domke, S. Ries, G. Reifschneider, A. Friedrich, P. Knorn, H. Landefeld, G. Niemczyk, P. Schicklmaier, C. Wernsdörfer, S. Windhagen, H. Albrecht, S. Schwab, . (2011) Health care situation of patients with relapsing-remitting multiple sclerosis receiving immunomodulatory therapy: a retrospective survey of more than 9000 German patients with MS. European Journal of Neurology 18:8, 1036-1045
CrossRef48
Seonghoon Kim, Rakwoo Chang, Charlotte Teunissen, Yeshitila Gebremichael, Axel Petzold. (2011) Neurofilament stoichiometry simulations during neurodegeneration suggest a remarkable self-sufficient and stable in vivo protein structure. Journal of the Neurological Sciences 307:1-2, 132-138
CrossRef49
Hans Lassmann, Jack van Horssen. (2011) The molecular basis of neurodegeneration in multiple sclerosis. FEBS Letters
CrossRef50
Jingya Zhang, Elisabeth G. Kramer, Linnea Asp, Dipankar J. Dutta, Kristina Navrazhina, Trinh Pham, John N. Mariani, Azeb Tadesse Argaw, Carmen V. Melendez-Vasquez, Gareth R. John. (2011) Promoting myelin repair and return of function in multiple sclerosis. FEBS Letters
CrossRef51
Richard Reynolds, Federico Roncaroli, Richard Nicholas, Bishan Radotra, Djordje Gveric, Owain Howell. (2011) The neuropathological basis of clinical progression in multiple sclerosis. Acta Neuropathologica 122:2, 155-170
CrossRef52
Christina J. Ansted, Robert S. Kennedy, Monique D. Johnson, Sandra Haas Binford. (2011) Meeting Highlights on Psychiatric Treatment Perspectives in Neurology: The 3rd Annual Chair Summit. Health Outcomes Research in Medicine 2:3, e183-e194
CrossRef53
Keith Feigenson, Mary Reid, Jill See, E Bryan Crenshaw III, Judith B Grinspan. (2011) Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation. ASN NEURO 3:3, 147-158
CrossRef54
Sara L. Montgomery, William J. Bowers. (2011) Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System. Journal of Neuroimmune Pharmacology
CrossRef55
Si-Fan Huang, Ying Ding, Jing-Wen Ruan, Wei Zhang, Jin-Lang Wu, Bing He, Yu-Jiao Zhang, Yan Li, Yuan-Shan Zeng. (2011) An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide. Neuroscience Research 70:3, 294-304
CrossRef56
L. Haider, M. T. Fischer, J. M. Frischer, J. Bauer, R. Hoftberger, G. Botond, H. Esterbauer, C. J. Binder, J. L. Witztum, H. Lassmann. (2011) Oxidative damage in multiple sclerosis lesions. Brain 134:7, 1914-1924
CrossRef57
D Pau, N Al Zubidi, S Yalamanchili, G T Plant, A G Lee. (2011) Optic neuritis. Eye 25:7, 833-842
CrossRef58
Bing Hu, Binbin Ye, Yang Yang, Kangshun Zhu, Zhuang Kang, Sichi Kuang, Lin Luo, Hong Shan. (2011) Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing–remitting multiple sclerosis. European Journal of Radiology 79:1, 101-107
CrossRef59
Kathleen A. Potter, Michael J. Kern, George Fullbright, Jacek Bielawski, Steven S. Scherer, Sabrina W. Yum, Jian J. Li, Hua Cheng, Xianlin Han, Jagadish Kummetha Venkata, P. Akbar Ali Khan, Bärbel Rohrer, Hiroko Hama. (2011) Central nervous system dysfunction in a mouse model of Fa2h deficiency. Glia 59:7, 1009-1021
CrossRef60
Majid Assadi, Reza Nemati, Iraj Nabipour, Hooman Salimipour, Abdullatif Amini. (2011) Radiolabeled annexin V imaging: A useful technique for determining apoptosis in multiple sclerosis. Medical Hypotheses 77:1, 43-46
CrossRef61
Lucas Schirmer, Jack P. Antel, Wolfgang Brück, Christine Stadelmann. (2011) Axonal Loss and Neurofilament Phosphorylation Changes Accompany Lesion Development and Clinical Progression in Multiple Sclerosis. Brain Pathology 21:4, 428-440
CrossRef62
Gilles Edan, Emmanuelle Leray. (2011) A new treatment era in multiple sclerosis: Clinical applications of new concepts. Journal of the Neurological Sciences 306:1-2, 170-172
CrossRef63
Fiona E. Costello, Alexander Klistorner, Randy Kardon. (2011) Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis. Ophthalmic Surgery, Lasers, and Imaging 42:4, S28-S40
CrossRef64
Xiaohua Xu, Arthur E. Warrington, Allan J. Bieber, Moses Rodriguez. (2011) Enhancing CNS Repair in Neurological Disease. CNS Drugs 25:7, 555-573
CrossRef65
T.H. Jensen, M. Bech, O. Bunk, A. Menzel, A. Bouchet, G. Le Duc, R. Feidenhans'l, F. Pfeiffer. (2011) Molecular X-ray computed tomography of myelin in a rat brain. NeuroImage 57:1, 124-129
CrossRef66
Ronald Antulov, Dominic A. Carone, Jared Bruce, Viritha Yella, Michael G. Dwyer, Christopher W. Tjoa, Ralph H. B. Benedict, Robert Zivadinov. (2011) Regionally Distinct White Matter Lesions Do Not Contribute to Regional Gray Matter Atrophy in Patients with Multiple Sclerosis. Journal of Neuroimaging 21:3, 210-218
CrossRef67
David Paling, Xavier Golay, Claudia Wheeler-Kingshott, Raju Kapoor, David Miller. (2011) Energy failure in multiple sclerosis and its investigation using MR techniques. Journal of Neurology
CrossRef68
Marcin Czepiel, Veerakumar Balasubramaniyan, Wandert Schaafsma, Mirjana Stancic, Harald Mikkers, Christian Huisman, Erik Boddeke, Sjef Copray. (2011) Differentiation of induced pluripotent stem cells into functional oligodendrocytes. Glia 59:6, 882-892
CrossRef69
Kelly Hares, Kevin Kemp, Elizabeth Gray, Neil Scolding, Alastair Wilkins. (2011) Neurofilament dot blot assays: Novel means of assessing axon viability in culture. Journal of Neuroscience Methods 198:2, 195-203
CrossRef70
Sangmin Lee, Lijing Xu, Yoojin Shin, Lidia Gardner, Anastasia Hartzes, F. Curtis Dohan, Cedric Raine, Ramin Homayouni, Michael C. Levin. (2011) A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease. Journal of Neuroimmunology 235:1-2, 56-69
CrossRef71
Ralph H. B. Benedict, Robert Zivadinov. (2011) Risk factors for and management of cognitive dysfunction in multiple sclerosis. Nature Reviews Neurology 7:6, 332-342
CrossRef72
Jordi Río, Manuel Comabella, Xavier Montalban. (2011) Multiple sclerosis: current treatment algorithms. Current Opinion in Neurology 24:3, 230-237
CrossRef73
Bernd C. Kieseier. (2011) The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis. CNS Drugs 25:6, 491-502
CrossRef74
G. Kitsos, E. T. Detorakis, S. Papakonstantinou, A. P. Kyritsis, S. H. Pelidou. (2011) Perimetric and peri-papillary nerve fibre layer thickness findings in multiple sclerosis. European Journal of Neurology 18:5, 719-725
CrossRef75
Gregory F. Wu, Enrique Alvarez. (2011) The Immunopathophysiology of Multiple Sclerosis. Neurologic Clinics 29:2, 257-278
CrossRef76
Hans Lassmann. (2011) The Architecture of Inflammatory Demyelinating Lesions: Implications for Studies on Pathogenesis. Neuropathology and Applied Neurobiologyno-no
CrossRef77
Robert J. Fox, Erik Beall, Pallab Bhattacharyya, Jacqueline T. Chen, Ken Sakaie. (2011) Advanced MRI in Multiple Sclerosis: Current Status and Future Challenges. Neurologic Clinics 29:2, 357-380
CrossRef78
I. N. Abdurasulova, V. M. Klimenko. (2011) Heterogeneity of the Mechanisms of Nerve Cell Damage in Demyelinating Autoimmune Diseases of the CNS. Neuroscience and Behavioral Physiology 41:4, 364-374
CrossRef79
Jaume Sastre-Garriga, Carlos Vila, Stephen Clissold, Xavier Montalban. (2011) THC and CBD oromucosal spray (Sativex ® ) in the management of spasticity associated with multiple sclerosis. Expert Review of Neurotherapeutics 11:5, 627-637
CrossRef80
M. Axelsson, C. Malmeström, S. Nilsson, S. Haghighi, L. Rosengren, J. Lycke. (2011) Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis. Journal of Neurology 258:5, 882-888
CrossRef81
Gavin Giovannoni. (2011) Promising Emerging Therapies for Multiple Sclerosis. Neurologic Clinics 29:2, 435-448
CrossRef82
S. Saidha, S. B. Syc, L. J. Balcer, E. M. Frohman, P. A. Calabresi. (2011) Reply: Retinal pathology in multiple sclerosis: insight into the mechanisms of neuronal pathology. Brain 134:5, e172-e172
CrossRef83
Mascha S. Recks, Klaus Addicks, Stefanie Kuerten. (2011) Spinal cord histopathology of MOG peptide 35–55-induced experimental autoimmune encephalomyelitis is time- and score-dependent. Neuroscience Letters 494:3, 227-231
CrossRef84
Naomi Hashiba, Shigemi Nagayama, Shin-ich Araya, Hiroyuki Inada, Yoshifumi Sonobe, Akio Suzumura, Makoto Matsui. (2011) Phenytoin at optimum doses ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells. Journal of Neuroimmunology 233:1-2, 112-119
CrossRef85
Hideyuki Yoshioka, Kuniyasu Niizuma, Masataka Katsu, Hiroyuki Sakata, Nobuya Okami, Pak H. Chan. (2011) Consistent Injury to Medium Spiny Neurons and White Matter in the Mouse Striatum after Prolonged Transient Global Cerebral Ischemia. Journal of Neurotrauma 28:4, 649-660
CrossRef86
Christian R. Rau, Katharina Hein, Muriel B. Sättler, Benedikt Kretzschmar, Carina Hillgruber, Bradford L. McRae, Ricarda Diem, Mathias Bähr. (2011) Anti-Inflammatory Effects of FTY720 Do Not Prevent Neuronal Cell Loss in a Rat Model of Optic Neuritis. The American Journal of Pathology 178:4, 1770-1781
CrossRef87
Ivana Nikić, Doron Merkler, Catherine Sorbara, Mary Brinkoetter, Mario Kreutzfeldt, Florence M Bareyre, Wolfgang Brück, Derron Bishop, Thomas Misgeld, Martin Kerschensteiner. (2011) A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 17:4, 495-499
CrossRef88
Zhihua Ren, Yan Wang, David Liebenson, Thomas Liggett, Rajendra Goswami, Dusan Stefoski, Roumen Balabanov. (2011) IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination. Journal of Neuroimmunology 233:1-2, 147-159
CrossRef89
Takao Kiriyama, Hiroshi Kataoka, Toshiaki Taoka, Yasuyo Tonomura, Mari Terashima, Masami Morikawa, Emi Tanizawa, Makoto Kawahara, Yoshiko Furiya, Kazuma Sugie, Kimihiko Kichikawa, Satoshi Ueno. (2011) Characteristic Neuroimaging in Patients with Tumefactive Demyelinating Lesions Exceeding 30 mm. Journal of Neuroimaging 21:2, e69-e77
CrossRef90
Judith Haas. (2011) Pathophysiology, assessment and management of multiple sclerosis spasticity: an update. Expert Review of Neurotherapeutics 11:4s, 3-8
CrossRef91
Elizabeth Gray, Mark Ginty, Kevin Kemp, Neil Scolding, Alastair Wilkins. (2011) Peroxisome proliferator-activated receptor-α agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function. European Journal of Neuroscience 33:8, 1421-1432
CrossRef92
Hormuzdiyar H. Dasenbrock, Seth A. Smith, Arzu Ozturk, Sheena K. Farrell, Peter A. Calabresi, Daniel S. Reich. (2011) Diffusion Tensor Imaging of the Optic Tracts in Multiple Sclerosis: Association with Retinal Thinning and Visual Disability. Journal of Neuroimaging 21:2, e41-e49
CrossRef93
Eric C. Klawiter, Robert E. Schmidt, Kathryn Trinkaus, Hsiao-Fang Liang, Matthew D. Budde, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross, Tammie L. Benzinger. (2011) Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords. NeuroImage 55:4, 1454-1460
CrossRef94
A. Ghazavi, G. Mosayebi. (2011) The Mechanism of Sesame Oil in Ameliorating Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice. Phytotherapy Researchn/a-n/a
CrossRef95
Massimiliano Cristofanilli, Violaine K. Harris, Aaron Zigelbaum, Andrea M. Goossens, Amy Lu, Hannah Rosenthal, Saud A. Sadiq. (2011) Mesenchymal stem cells enhance the engraftment and myelinating ability of allogeneic oligodendrocyte progenitors in dysmyelinated mice. Stem Cells and Development110306223226020
CrossRef96
Amena W. Smith, Bently P. Doonan, William R. Tyor, Nada Abou-Fayssal, Azizul Haque, Naren L. Banik. (2011) Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients. Journal of Neuroimmunology 232:1-2, 179-185
CrossRef97
Nataly Urshansky, Karin Mausner-Fainberg, Eitan Auriel, Keren Regev, Natan M. Bornstein, Arnon Karni. (2011) Reduced production of noggin by immune cells of patients with relapsing–remitting multiple sclerosis. Journal of Neuroimmunology 232:1-2, 171-178
CrossRef98
Orhan Aktas, Hans-Peter Hartung. (2011) Beyond axonal transection: Hippocampal damage in multiple sclerosis. Annals of Neurology 69:3, 433-436
CrossRef99
Jingya Zhang, Elisabeth G. Kramer, Sean Mahase, Dipankar J. Dutta, Virginie Bonnamain, Azeb T. Argaw, Gareth R. John. (2011) Targeting Oligodendrocyte Protection and Remyelination in Multiple Sclerosis. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 78:2, 244-257
CrossRef100
Jeffery D. Haines, Matilde Inglese, Patrizia Casaccia. (2011) Axonal Damage in Multiple Sclerosis. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 78:2, 231-243
CrossRef101
Ranjan Dutta, Ansi Chang, Mary K. Doud, Grahame J. Kidd, Michael V. Ribaudo, Elizabeth A. Young, Robert J. Fox, Susan M. Staugaitis, Bruce D. Trapp. (2011) Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients. Annals of Neurology 69:3, 445-454
CrossRef102
A. Mike, B. I. Glanz, P. Hildenbrand, D. Meier, K. Bolden, M. Liguori, E. Dell'Oglio, B. C. Healy, R. Bakshi, C. R. G. Guttmann. (2011) Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging. American Journal of Neuroradiology 32:3, 515-521
CrossRef103
Graham R. Campbell, Don J. Mahad. (2011) Mitochondrial changes associated with demyelination: Consequences for axonal integrity. Mitochondrion
CrossRef104
Lauren V. Zollinger, Tae Ho Kim, Kenneth Hill, Eun K. Jeong, John W. Rose. (2011) Using diffusion tensor imaging and immunofluorescent assay to evaluate the pathology of multiple sclerosis. Journal of Magnetic Resonance Imaging 33:3, 557-564
CrossRef105
Massimiliano Calabrese, Francesca Rinaldi, Paola Grossi, Paolo Gallo. (2011) Cortical pathology and cognitive impairment in multiple sclerosis. Expert Review of Neurotherapeutics 11:3, 425-432
CrossRef106
Cris S Constantinescu, Nasr Farooqi, Kate O'Brien, Bruno Gran. (2011) Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). British Journal of Pharmacologyno-no
CrossRef107
Joong Hee Kim, Tzy-Haw Wu, Matthew D. Budde, Jin-Moo Lee, Sheng-Kwei Song. (2011) Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse model. NMR in Biomedicine 24:2, 163-169
CrossRef108
Jack van Horssen, Maarten E. Witte, Gerty Schreibelt, Helga E. de Vries. (2011) Radical changes in multiple sclerosis pathogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:2, 141-150
CrossRef109
Joseph M. Antony, Andre M. DesLauriers, Rakesh K. Bhat, Kristofer K. Ellestad, Christopher Power. (2011) Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:2, 162-176
CrossRef110
Jennifer E. Tobin, Mingqiang Xie, Tuan Q. Le, Sheng-Kwei Song, Regina C. Armstrong. (2011) Reduced Axonopathy and Enhanced Remyelination After Chronic Demyelination in Fibroblast Growth Factor 2 (Fgf2)-Null Mice. Journal of Neuropathology and Experimental Neurology 70:2, 157-165
CrossRef111
L. Celso Hygino da Cruz, Raquel Ribeiro Batista, Roberto Cortes Domingues, Frederik Barkhof. (2011) Diffusion Magnetic Resonance Imaging in Multiple Sclerosis. Neuroimaging Clinics of North America 21:1, 71-88
CrossRef112
S. Vergo, M. J. Craner, R. Etzensperger, K. Attfield, M. A. Friese, J. Newcombe, M. Esiri, L. Fugger. (2011) Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model. Brain 134:2, 571-584
CrossRef113
D. Dinacci, A. Tessitore, A. Russo, M. L. Bonis, L. Lavorgna, O. Picconi, R. Sacco, S. Bonavita, A. Gallo, G. Servillo, L. Marcuccio, M. Comerci, P. Galletti, B. Alfano, G. Tedeschi. (2011) BDNF Val66Met polymorphism and brain volumes in multiple sclerosis. Neurological Sciences 32:1, 117-123
CrossRef114
Fiona Costello. (2011) Evaluating the Use of Optical Coherence Tomography in Optic Neuritis. Multiple Sclerosis International 2011, 1-9
CrossRef115
Carolina de Medeiros Rimkus, Thiago de Faria Junqueira, Katarina Paz Lyra, Marcel P. Jackowski, Melissa A. R. Machado, Eliane C. Miotto, Dagoberto Callegaro, Maria Concepción García Otaduy, Claudia da Costa Leite. (2011) Corpus Callosum Microstructural Changes Correlate with Cognitive Dysfunction in Early Stages of Relapsing-Remitting Multiple Sclerosis: Axial and Radial Diffusivities Approach. Multiple Sclerosis International 2011, 1-7
CrossRef116
Michael Khalil, Charlotte Teunissen, Christian Langkammer. (2011) Iron and Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International 2011, 1-6
CrossRef117
Jeroen FJ Bogie, Piet Stinissen, Niels Hellings, Jerome JA Hendriks. (2011) Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation. Journal of Neuroinflammation 8:1, 85
CrossRef118
Natalya Shneyder, Meghan K. Harris, Alireza Minagar. 2011. Movement disorders in patients with multiple sclerosis. , 307-314.
CrossRef119
Mazen Abu-Mugheisib, Reiner Benecke, Uwe K. Zettl. (2011) Repeated Intrathecal Triamcinolone Acetonide Administration in Progressive Multiple Sclerosis: A Review. Multiple Sclerosis International 2011, 1-8
CrossRef120
Graham R. Campbell, Don J. Mahad. (2011) Mitochondria as Crucial Players in Demyelinated Axons: Lessons from Neuropathology and Experimental Demyelination. Autoimmune Diseases 2011, 1-9
CrossRef121
Paolo Zamboni, Erica Menegatti, Bianca Weinstock-Guttman, Michael G Dwyer, Claudiu V Schirda, Anna M Malagoni, David Hojnacki, Cheryl Kennedy, Ellen Carl, Niels Bergsland, Christopher Magnano, Ilaria Bartolomei, Fabrizio Salvi, Robert Zivadinov. (2011) Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report. BMC Medicine 9:1, 22
CrossRef122
Martin Gunnarsson, Clas Malmeström, Markus Axelsson, Peter Sundström, Charlotte Dahle, Magnus Vrethem, Tomas Olsson, Fredrik Piehl, Niklas Norgren, Lars Rosengren, Anders Svenningsson, Jan Lycke. (2011) Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab. Annals of Neurology 69:1, 83-89
CrossRef123
Kennichi Dowdell, Caroline Whitacre. 2011. Regulation of Inflammatory Autoimmune Diseases. .
CrossRef124
Ranjan Dutta, Bruce D. Trapp. (2011) Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Progress in Neurobiology 93:1, 1-12
CrossRef125
Olatz Pampliega, María Domercq, Federico N Soria, Pablo Villoslada, Alfredo Rodríguez-Antigüedad, Carlos Matute. (2011) Increased expression of cystine/glutamate antiporter in multiple sclerosis. Journal of Neuroinflammation 8:1, 63
CrossRef126
Elly JF Vereyken, Priscilla DAM Heijnen, Wia Baron, Elga HE de Vries, Christine D Dijkstra, Charlotte E Teunissen. (2011) Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types. Journal of Neuroinflammation 8:1, 58
CrossRef127
Irena Dujmovic. (2011) Cerebrospinal Fluid and Blood Biomarkers of Neuroaxonal Damage in Multiple Sclerosis. Multiple Sclerosis International 2011, 1-18
CrossRef128
Kristin M. Galetta, Peter A. Calabresi, Elliot M. Frohman, Laura J. Balcer. (2011) Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration. Neurotherapeutics 8:1, 117-132
CrossRef129
M. J. Eikelenboom, B. M. J. Uitdehaag, A. Petzold. (2011) Blood and CSF Biomarker Dynamics in Multiple Sclerosis: Implications for Data Interpretation. Multiple Sclerosis International 2011, 1-6
CrossRef130
Melissa M. Gresle, Helmut Butzkueven, Gerry Shaw. (2011) Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International 2011, 1-7
CrossRef131
Miriam E. Van Strien, Benjamin Drukarch, John G. Bol, Paul Van Der Valk, Jack Van Horssen, Wouter H. Gerritsen, John J. Breve, Anne-Marie Van Dam. (2011) Appearance of Tissue Transglutaminase in Astrocytes in Multiple Sclerosis Lesions: A Role in Cell Adhesion and Migration?. Brain Pathology 21:1, 44-54
CrossRef132
Scott Kolbe, Clare Bajraszewski, Caron Chapman, Tan Nguyen, Peter Mitchell, Mark Paine, Helmut Butzkueven, Leigh Johnston, Trevor Kilpatrick, Gary Egan. (2011) Diffusion tensor imaging of the optic radiations after optic neuritis. Human Brain Mappingn/a-n/a
CrossRef133
Mehrdad Alirezaei, Christopher C. Kemball, J. Lindsay Whitton. (2011) Autophagy, inflammation and neurodegenerative disease. European Journal of Neuroscience 33:2, 197-204
CrossRef134
Yan Fu, Terra J. Frederick, Terry B. Huff, Gwendolyn E. Goings, Stephen D. Miller, Ji-Xin Cheng. (2011) Paranodal myelin retraction in relapsing experimental autoimmune encephalomyelitis visualized by coherent anti-Stokes Raman scattering microscopy. Journal of Biomedical Optics 16:10, 106006
CrossRef135
Petra Huehnchen, Timour Prozorovski, Philipp Klaissle, Anne Lesemann, Jens Ingwersen, Susanne A. Wolf, Andreas Kupsch, Orhan Aktas, Barbara Steiner. (2011) Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation. Glia 59:1, 132-142
CrossRef136
Tatsuo Kohriyama. (2011) Clinically isolated syndrome: prognostic markers for conversion to multiple sclerosis and initiation of disease-modifying therapy. Rinsho Shinkeigaku 51:3, 179-187
CrossRef137
Kevin S. Carbajal, Juan L. Miranda, Michelle R. Tsukamoto, Thomas E. Lane. (2011) CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination. Glian/a-n/a
CrossRef138
Rajesh Kumar, Haidang D. Nguyen, Paul M. Macey, Mary A. Woo, Ronald M. Harper. (2011) Regional brain axial and radial diffusivity changes during development. Journal of Neuroscience Researchn/a-n/a
CrossRef139
Khader M. Hasan, Indika S. Walimuni, Humaira Abid, Jerry S. Wolinsky, Ponnada A. Narayana. (2011) Multi-modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis. Journal of Magnetic Resonance Imagingn/a-n/a
CrossRef140
Amir-Hadi Maghzi, Aimee Borazanci, Jeanie McGee, J. Steven Alexander, Eduardo Gonzalez-Toledo, Alireza Minagar. 2011. Multiple SclerosisPathophysiology, Clinical Features, Diagnosis, and Management. , 1-23.
CrossRef141
Ying Wu, Hongyan Du, Pippa Storey, Christopher Glielmi, Fiona Malone, Shawn Sidharthan, Ann Ragin, Paul S. Tofts, Robert R. Edelman. (2011) Comprehensive brain analysis with automated high-resolution magnetization transfer measurements. Journal of Magnetic Resonance Imagingn/a-n/a
CrossRef142
Beatriz Moreno, JohnPaul Jukes, Nuria Vergara-Irigaray, O Errea, Pablo Villoslada, V Hugh Perry, Tracey A NewmanPhD. (2011) Systemic inflammation induces axon injury during brain inflammation. Annals of Neurologyn/a-n/a
CrossRef143
Andrew P.D Henderson, Daniel R. Altmann, Trip S. Anand, Katherine A. Miszkiel, Patricio G. Schlottmann, Steve J. Jones, David F. Garway-Heath, Gordon T. Plant, David H. Miller. (2011) Early factors associated with axonal loss after optic neuritis. Annals of Neurologyn/a-n/a
CrossRef144
Eva Zindler, Frauke Zipp. (2010) Neuronal injury in chronic CNS inflammation. Best Practice & Research Clinical Anaesthesiology 24:4, 551-562
CrossRef145
Peter Göttle, David Kremer, Sebastian Jander, Veysel Ödemis, Jürgen Engele, Hans-Peter Hartung, Patrick Küry. (2010) Activation of CXCR7 receptor promotes oligodendroglial cell maturation. Annals of Neurology 68:6, 915-924
CrossRef146
Ahmet Z. Burakgazi, Ahmet Höke. (2010) Respiratory muscle weakness in peripheral neuropathies. Journal of the Peripheral Nervous System 15:4, 307-313
CrossRef147
Alastair Wilkins, Yoichi Kondo, Jonathan Song, Shujun Liu, Alastair Compston, Joel A. Black, Stephen G. Waxman, Ian D. Duncan. (2010) Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination. Journal of Neuropathology and Experimental Neurology 69:12, 1256-1269
CrossRef148
Christopher Siatskas, Natalie L. Payne, Martin A. Short, Claude C. A. Bernard. (2010) A Consensus Statement Addressing Mesenchymal Stem Cell Transplantation for Multiple Sclerosis: It’s Time!. Stem Cell Reviews and Reports 6:4, 500-506
CrossRef149
Devon S. Conway, Jeffrey A. Cohen. (2010) Multiple sclerosis: Mechanisms of disability accumulation in multiple sclerosis. Nature Reviews Neurology 6:12, 654-655
CrossRef150
Axel Petzold, Tjeerd Mondria, Jens Kuhle, Maria A. Rocca, Jan Cornelissen, Peter te Boekhorst, Bob Lowenberg, Gavin Giovannoni, Massimo Filippi, Ludwig Kappos, Rogier Hintzen. (2010) Evidence for acute neurotoxicity after chemotherapy. Annals of Neurology 68:6, 806-815
CrossRef151
Ranjan Dutta, Bruce D. Trapp. (2010) Gene expression profiling in multiple sclerosis brain. Neurobiology of Disease
CrossRef152
Clare J. Fowler, Catherine Dalton, Jalesh N. Panicker. (2010) Review of Neurologic Diseases for the Urologist. Urologic Clinics of North America 37:4, 517-526
CrossRef153
Holly S. Cate, Jennifer K. Sabo, Daniel Merlo, Dennis Kemper, Tim D. Aumann, Julien Robinson, Toby D. Merson, Ben Emery, Victoria M. Perreau, Trevor J. Kilpatrick. (2010) Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination. Journal of Neurochemistry 115:1, 11-22
CrossRef154
Owain W. Howell, Jon L. Rundle, Anurag Garg, Masayuki Komada, Peter J. Brophy, Richard Reynolds. (2010) Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology 69:10, 1017-1033
CrossRef155
Y. Zhang, F. Jalili, N. Ouamara, A. Zameer, G. Cosentino, M. Mayne, L. Hayardeny, J.P. Antel, A. Bar-Or, G.R. John. (2010) Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: Role of IGF-2. Journal of Neuroimmunology 227:1-2, 71-79
CrossRef156
Christiane Wegner, Christine Stadelmann, Ramona Pförtner, Emanuel Raymond, Sara Feigelson, Ronen Alon, Bracha Timan, Liat Hayardeny, Wolfgang Brück. (2010) Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 227:1-2, 133-143
CrossRef157
J. Sellner, L. Schirmer, B. Hemmer, M. Mühlau. (2010) Radiologisch-isoliertes Syndrom. Der Nervenarzt 81:10, 1208-1217
CrossRef158
Rachel A. Farrell, Gavin Giovannoni. (2010) Current and Future Role of Interferon Beta in the Therapy of Multiple Sclerosis. Journal of Interferon & Cytokine Research 30:10, 715-726
CrossRef159
Johann Sellner, Lucas Schirmer, Bernhard Hemmer, Mark Mühlau. (2010) The radiologically isolated syndrome: take action when the unexpected is uncovered?. Journal of Neurology 257:10, 1602-1611
CrossRef160
Géraldine Androdias, Richard Reynolds, Marie Chanal, Cécile Ritleng, Christian Confavreux, Serge Nataf. (2010) Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords. Annals of Neurology 68:4, 465-476
CrossRef161
Sultan Darvesh, Andrea M. LeBlanc, Ian R. Macdonald, George A. Reid, Virender Bhan, Robert J. Macaulay, John D. Fisk. (2010) Butyrylcholinesterase activity in multiple sclerosis neuropathology. Chemico-Biological Interactions 187:1-3, 425-431
CrossRef162
Muriel B. Sättler, Mathias Bähr. (2010) Future neuroprotective strategies. Experimental Neurology 225:1, 40-47
CrossRef163
J. Furby, T. Hayton, D. Altmann, R. Brenner, J. Chataway, K. J. Smith, D. H. Miller, R. Kapoor. (2010) A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosis. Journal of Neurology 257:9, 1508-1516
CrossRef164
Volker Siffrin, Helena Radbruch, Robert Glumm, Raluca Niesner, Magdalena Paterka, Josephine Herz, Tina Leuenberger, Sabrina M. Lehmann, Sarah Luenstedt, Jan Leo Rinnenthal, Gregor Laube, Hervé Luche, Seija Lehnardt, Hans-Joerg Fehling, Oliver Griesbeck, Frauke Zipp. (2010) In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis. Immunity 33:3, 424-436
CrossRef165
Dorota Sadowski, Mary E. Kiel, Marisa Apicella, Aileen G. Arriola, Cui Ping Chen, Randall D. McKinnon. (2010) Teratogenic Potential in Cultures Optimized for Oligodendrocyte Development from Mouse Embryonic Stem Cells. Stem Cells and Development 19:9, 1343-1353
CrossRef166
J.I. Rojas, L. Patrucco, C. Besada, L. Bengolea, E. Cristiano. (2010) Atrofia cerebral en pacientes con síndrome desmielinizante aislado. Neurología 25:7, 430-434
CrossRef167
M P Kurnellas, H Li, M R Jain, S N Giraud, A B Nicot, A Ratnayake, R F Heary, S Elkabes. (2010) Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons. Cell Death and Differentiation 17:9, 1501-1510
CrossRef168
Josephine Herz, Frauke Zipp, Volker Siffrin. (2010) Neurodegeneration in autoimmune CNS inflammation. Experimental Neurology 225:1, 9-17
CrossRef169
A. P. D. Henderson, D. R. Altmann, A. S. Trip, C. Kallis, S. J. Jones, P. G. Schlottmann, D. F. Garway-Heath, G. T. Plant, D. H. Miller. (2010) A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials. Brain 133:9, 2592-2602
CrossRef170
Hans Lassmann. (2010) Axonal and neuronal pathology in multiple sclerosis: What have we learnt from animal models. Experimental Neurology 225:1, 2-8
CrossRef171
, O. Fernández, V. Fernández, T. Arbizu, G. Izquierdo, I. Bosca, R. Arroyo, J. A. García Merino, E. Ramón. (2010) Characteristics of multiple sclerosis at onset and delay of diagnosis and treatment in Spain (The Novo Study). Journal of Neurology 257:9, 1500-1507
CrossRef172
Tobias Derfuss, Chris Linington, Reinhard Hohlfeld, Edgar Meinl. (2010) Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury. Journal of Molecular Medicine 88:8, 753-761
CrossRef173
R. A. Linker, D.-H. Lee, S. Demir, S. Wiese, N. Kruse, I. Siglienti, E. Gerhardt, H. Neumann, M. Sendtner, F. Luhder, R. Gold. (2010) Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 133:8, 2248-2263
CrossRef174
A. García Merino, O. Fernández, X. Montalbán, C. de Andrés, T. Arbizu. (2010) Documento de consenso de la Sociedad Española de Neurología sobre el uso de medicamentos en esclerosis múltiple: escalado terapéutico. Neurología 25:6, 378-390
CrossRef175
E. Leray, J. Yaouanq, E. Le Page, M. Coustans, D. Laplaud, J. Oger, G. Edan. (2010) Evidence for a two-stage disability progression in multiple sclerosis. Brain 133:7, 1900-1913
CrossRef176
Mingqiang Xie, Jennifer E. Tobin, Matthew D. Budde, Chin-I Chen, Kathryn Trinkaus, Anne H. Cross, Dennis P. McDaniel, Sheng-Kwei Song, Regina C. Armstrong. (2010) Rostrocaudal Analysis of Corpus Callosum Demyelination and Axon Damage Across Disease Stages Refines Diffusion Tensor Imaging Correlations With Pathological Features. Journal of Neuropathology and Experimental Neurology 69:7, 704-716
CrossRef177
Michael P. Coleman, Marc R. Freeman. (2010) Wallerian Degeneration, Wld S , and Nmnat. Annual Review of Neuroscience 33:1, 245-267
CrossRef178
Veronique E. Miron, Samuel K. Ludwin, Peter J. Darlington, Andrew A. Jarjour, Betty Soliven, Timothy E. Kennedy, Jack P. Antel. (2010) Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices. The American Journal of Pathology 176:6, 2682-2694
CrossRef179
P. A. Calabresi, L. J. Balcer, E. M. Frohman. (2010) Retinal pathology in multiple sclerosis: insight into the mechanisms of neuronal pathology. Brain 133:6, 1575-1577
CrossRef180
Gabrièle Piaton, Robert M. Gould, Catherine Lubetzki. (2010) Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair. Journal of Neurochemistryno-no
CrossRef181
S. D. Roosendaal, M. M. Schoonheim, H. E. Hulst, E. J. Sanz-Arigita, S. M. Smith, J. J. G. Geurts, F. Barkhof. (2010) Resting state networks change in clinically isolated syndrome. Brain 133:6, 1612-1621
CrossRef182
S. Amadio, C. Montilli, R. Magliozzi, G. Bernardi, R. Reynolds, C. Volonte. (2010) P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis. Cerebral Cortex 20:6, 1263-1273
CrossRef183
Tobias D. Merson, Michele D. Binder, Trevor J. Kilpatrick. (2010) Role of Cytokines as Mediators and Regulators of Microglial Activity in Inflammatory Demyelination of the CNS. NeuroMolecular Medicine 12:2, 99-132
CrossRef184
Tomasz Dziedzic, Imke Metz, Tobias Dallenga, Fatima Barbara König, Sven Müller, Christine Stadelmann, Wolfgang Brück. (2010) Wallerian Degeneration: A Major Component of Early Axonal Pathology in Multiple Sclerosis. Brain Pathologyno-no
CrossRef185
Ernst-Wilhelm Radue, William H. Stuart, Peter A. Calabresi, Christian Confavreux, Steven L. Galetta, Richard A. Rudick, Fred D. Lublin, Bianca Weinstock-Guttman, Daniel R. Wynn, Elizabeth Fisher. (2010) Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis. Journal of the Neurological Sciences 292:1-2, 28-35
CrossRef186
Jane Marian Anderson, Rickie Patani, Richard Reynolds, Richard Nicholas, Alastair Compston, Maria Grazia Spillantini, Siddharthan Chandran. (2010) Abnormal tau phosphorylation in primary progressive multiple sclerosis. Acta Neuropathologica 119:5, 591-600
CrossRef187
Heng Gao, Ying Gao, Xiaohong Li, Aiguo Shen, Meijuan Yan. (2010) Spatiotemporal Patterns of Dexamethasone-Induced Ras Protein 1 Expression in the Central Nervous System of Rats with Experimental Autoimmune Encephalomyelitis. Journal of Molecular Neuroscience 41:1, 198-209
CrossRef188
Gianvito Martino, Robin J. M. Franklin, Anne Baron Van Evercooren, Douglas A. Kerr. (2010) Stem cell transplantation in multiple sclerosis: current status and future prospects. Nature Reviews Neurology 6:5, 247-255
CrossRef189
Frauke Seehusen, Wolfgang Baumgärtner. (2010) Axonal Pathology and Loss Precede Demyelination and Accompany Chronic Lesions in a Spontaneously Occurring Animal Model of Multiple Sclerosis. Brain Pathology 20:3, 551-559
CrossRef190
Bogdan Beirowski, Antal Nógrádi, Elisabetta Babetto, Guillermo Garcia-Alias, Michael P. Coleman. (2010) Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration. Journal of Neuropathology and Experimental Neurology 69:5, 455-472
CrossRef191
David P. Stirling, Peter K. Stys. (2010) Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation. Trends in Molecular Medicine 16:4, 160-170
CrossRef192
Steven Petratos, Michael F. Azari, Ezgi Ozturk, Roula Papadopoulos, Claude C.A. Bernard. (2010) Novel Therapeutic Targets for Axonal Degeneration in Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology 69:4, 323-334
CrossRef193
Klaus-Armin Nave. (2010) Myelination and the trophic support of long axons. Nature Reviews Neuroscience 11:4, 275-283
CrossRef194
Yuhong Yang, Yue Liu, Ping Wei, Haiyan Peng, Ryan Winger, Rehana Z. Hussain, Li-Hong Ben, Petra D. Cravens, Anne R. Gocke, Krishna Puttaparthi, Michael K. Racke, Dana M. McTigue, Amy E. Lovett-Racke. (2010) Silencing Nogo-A promotes functional recovery in demyelinating disease. Annals of Neurology 67:4, 498-507
CrossRef195
Anneke Van der Walt, Helmut Butzkueven, Scott Kolbe, Mark Marriott, Estella Alexandrou, Melissa Gresle, Gary Egan, Trevor Kilpatrick. (2010) Neuroprotection in multiple sclerosis: A therapeutic challenge for the next decade. Pharmacology & Therapeutics 126:1, 82-93
CrossRef196
Volker Siffrin, Johannes Vogt, Helena Radbruch, Robert Nitsch, Frauke Zipp. (2010) Multiple sclerosis – candidate mechanisms underlying CNS atrophy. Trends in Neurosciences 33:4, 202-210
CrossRef197
Christine Betard, Filippo Martinelli Boneschi, Paulo Caramelli. 2010. Biomarkers in Clinical Drug Development: Parallel Analysis of Alzheimer Disease and Multiple Sclerosis. .
CrossRef198
Jerold Chun, Hans-Peter Hartung. (2010) Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis. Clinical Neuropharmacology 33:2, 91-101
CrossRef199
Marie Namey, June Halper, Shirley OʼLeary, Jill Beavin, Cynthia Bishop. (2010) Best Practices in Multiple Sclerosis. Journal of Infusion Nursing 33:2, 98-111
CrossRef200
Orhan Aktas, Bernd Kieseier, Hans-Peter Hartung. (2010) Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis. Trends in Neurosciences 33:3, 140-152
CrossRef201
C. Oreja-Guevara, S. Noval, B. Manzano, E. Diez-Tejedor. (2010) Neuritis óptica asociada o no a esclerosis múltiple: estudio estructural y funcional. Neurología 25:2, 78-82
CrossRef202
Omar Khan, Massimo Filippi, Mark S. Freedman, Frederik Barkhof, Paula Dore-Duffy, Hans Lassmann, Bruce Trapp, Amit Bar-Or, Imad Zak, Marilyn J. Siegel, Robert Lisak. (2010) Chronic cerebrospinal venous insufficiency and multiple sclerosis. Annals of Neurology 67:3, 286-290
CrossRef203
José C Álvarez-Cermeño, Lucienne Costa-Frossard, Luisa M Villar. (2010) Importance of age at diagnosis in multiple sclerosis. Expert Review of Neurotherapeutics 10:3, 341-342
CrossRef204
M. Filippi, M.A. Rocca. (2010) Dirty-Appearing White Matter: A Disregarded Entity in Multiple Sclerosis. American Journal of Neuroradiology 31:3, 390-391
CrossRef205
C. Oreja-Guevara, S. Noval, B. Manzano, E. Diez-Tejedor. (2010) Optic neuritis, multiple sclerosis-related or not: Structural and functional study. Neurología (English Edition) 25:2, 78-82
CrossRef206
Stefan Mikkat, Peter Lorenz, Christian Scharf, Xinhua Yu, Michael O. Glocker, Saleh M. Ibrahim. (2010) MS characterization of qualitative protein polymorphisms in the spinal cords of inbred mouse strains. PROTEOMICSNA-NA
CrossRef207
Dimitrios Papadopoulos, Jon Rundle, Ryan Patel, Ian Marshall, Jennifer Stretton, Rachel Eaton, Jill C. Richardson, Maria I. Gonzalez, Karen L. Philpott, Richard Reynolds. (2010) FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses. Journal of Neuroscience Research 88:2, 346-359
CrossRef208
Julia M. Edgar, Mailis C. McCulloch, Paul Montague, Angus M. Brown, Sebastian Thilemann, Laura Pratola, Fredrik I. Gruenenfelder, Ian R. Griffiths, Klaus-Armin Nave. (2010) Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease. EMBO Molecular Medicine 2:2, 42-50
CrossRef209
Jin Young Kim, Siming Shen, Karen Dietz, Ye He, Owain Howell, Richard Reynolds, Patrizia Casaccia. (2010) HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nature Neuroscience 13:2, 180-189
CrossRef210
Panitha Jindahra, Thomas R Hedges, Carlos E Mendoza-Santiesteban, Gordon T Plant. (2010) Optical coherence tomography of the retina: applications in neurology. Current Opinion in Neurology 23:1, 16-23
CrossRef211
Robert H Miller. (2010) Renegade nuclear enzymes disrupt axonal integrity. Nature Neuroscience 13:2, 143-144
CrossRef212
Peizhong Mao, P. Hemachandra Reddy. (2010) Is multiple sclerosis a mitochondrial disease?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802:1, 66-79
CrossRef213
Nina Drøjdahl, Helle Hvilsted Nielsen, Jonathan E. Gardi, Andreas Wree, Alan C. Peterson, Jens Randel Nyengaard, Joël Eyer, Bente Finsen. (2010) Axonal plasticity elicits long-term changes in oligodendroglia and myelinated fibers. Glia 58:1, 29-42
CrossRef214
Hans Lassmann. (2010) What drives disease in multiple sclerosis: Inflammation or neurodegeneration?. Clinical and Experimental Neuroimmunology 1:1, 2-11
CrossRef215
Joshua Pasol, William Feuer, Cui Yang, Gerry Shaw, Randy Kardon, John Guy. (2010) Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment. Multiple Sclerosis International 2010, 1-10
CrossRef216
John R Guy, Xiaoping Qi. 2010. Optic neuritis. , 278-288.
CrossRef217
Jayasri Das Sarma. (2010) A Mechanism of Virus-Induced Demyelination. Interdisciplinary Perspectives on Infectious Diseases 2010, 1-28
CrossRef218
M. Kelly Guyton, Arabinda Das, Supriti Samantaray, Gerald C. Wallace, Jonathan T. Butler, Swapan K. Ray, Naren L. Banik. (2010) Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis. Journal of Neuroscience ResearchNA-NA
CrossRef219
M.S. Vishwas, T. Chitnis, R. Pienaar, B.C. Healy, P.E. Grant. (2010) Tract-Based Analysis of Callosal, Projection, and Association Pathways in Pediatric Patients with Multiple Sclerosis: A Preliminary Study. American Journal of Neuroradiology 31:1, 121-128
CrossRef220
A. Espinosa-Jeffrey, S. Hitoshi, P. Zhao, O. Awosika, C. Agbo, E. Olaniyan, J. Garcia, R. Valera, A. Thomassian, R. Chang-Wei, M. Yamaguchi, J. de Vellis, K. Ikenaka. (2010) Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression. Journal of Neuroscience ResearchNA-NA
CrossRef221
Sune N. Jespersen, Carsten R. Bjarkam, Jens R. Nyengaard, M. Mallar Chakravarty, Brian Hansen, Thomas Vosegaard, Leif Østergaard, Dmitriy Yablonskiy, Niels Chr. Nielsen, Peter Vestergaard-Poulsen. (2010) Neurite density from magnetic resonance diffusion measurements at ultrahigh field: Comparison with light microscopy and electron microscopy. NeuroImage 49:1, 205-216
CrossRef222
Kate O’Brien, Bruno Gran, Abdolmohamad Rostami. (2010) T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy 2:1, 99-115
CrossRef223
Ulf Schminke, Leif Lorenz, Michael Kirsch, Bettina von Sarnowski, Alexander V. Khaw, Christof Kessler, Alexander Dressel. (2010) Diameter Assessment of the Third Ventricle with Transcranial Sonography in Patients with Multiple Sclerosis. Journal of Neuroimaging 20:1, 53-57
CrossRef224
Hideyuki Takeuchi. (2010) Neurotoxicity by microglia: Mechanisms and potential therapeutic strategy. Clinical and Experimental Neuroimmunology 1:1, 12-21
CrossRef225
Sriram Ramanan, Weiling Zhao, David R. Riddle, Mike E. Robbins. (2010) Role of PPARs in Radiation-Induced Brain Injury. PPAR Research 2010, 1-12
CrossRef226
Yueting Zhang, Jingya Zhang, Kristina Navrazhina, Azeb Tadesse Argaw, Andleeb Zameer, Blake T. Gurfein, Celia F. Brosnan, Gareth R. John. (2010) TGFβ1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation. GliaNA-NA
CrossRef227
J.I. Rojas, L. Patrucco, C. Besada, L. Bengolea, E. Cristiano. (2010) Brain Atrophy in Clinically Isolated Syndrome. Neurología (English Edition) 25:7, 430-434
CrossRef228
A. García Merino, O. Fernández, X. Montalbán, C. de Andrés, T. Arbizu. (2010) Spanish Neurology Society consensus document on the use of drugs in multiple sclerosis: Escalating therapy. Neurología (English Edition) 25:6, 378-390
CrossRef229
E. García-Martín, V. Pueyo, J. Fernández, C. Almárcegui, I. Dolz, J. Martín, J.R. Ara, F.M. Honrubia. (2010) Atrophy of the retinal nerve fibre layer in multiple sclerosis patients. Prospective study with two years follow-up. Archivos de la Sociedad Española de Oftalmología (English Edition) 85:5, 179-186
CrossRef230
Gilles Defer, Bruno Brochet, Jean Pelletier. 2010. Physiopathologie, épidémiologie. , 5-9.
CrossRef231
B. Oliver, T. Órpez, C. Mayorga, M.J. Pinto-Medel, L. Leyva, C. López-Gómez, C. Marín, G. Luque, J. Ortega-Pinazo, O. Fernández. (2009) Neutralizing antibodies against IFN beta in patients with multiple sclerosis: A comparative study of two cytopathic effect tests (CPE) for their detection. Journal of Immunological Methods 351:1-2, 41-45
CrossRef232
Lorenzo De Santi, Pasquale Annunziata, Edoardo Sessa, Placido Bramanti. (2009) Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune encephalomyelitis and multiple sclerosis. Journal of the Neurological Sciences 287:1-2, 17-26
CrossRef233
Xavier Montalban. (2009) Early treatment: PreCISe-ly what the patient needs. Journal of the Neurological Sciences 287, S2-S6
CrossRef234
Nathalie Koning, Bernard M.J. Uitdehaag, Inge Huitinga, Robert M. Hoek. (2009) Restoring immune suppression in the multiple sclerosis brain. Progress in Neurobiology 89:4, 359-368
CrossRef235
D.K. Crawford, M. Mangiardi, X. Xia, H.E. López-Valdés, S.K. Tiwari-Woodruff. (2009) Functional recovery of callosal axons following demyelination: a critical window. Neuroscience 164:4, 1407-1421
CrossRef236
Allan MacKenzie-Graham, Seema K. Tiwari-Woodruff, Gaurav Sharma, Cynthia Aguilar, Kieumai T. Vo, Lauren V. Strickland, Laurie Morales, Boma Fubara, Melanie Martin, Russell E. Jacobs, G. Allan Johnson, Arthur W. Toga, Rhonda R. Voskuhl. (2009) Purkinje cell loss in experimental autoimmune encephalomyelitis. NeuroImage 48:4, 637-651
CrossRef237
Oscar Fernández, Alfredo R-Antigüedad, María Jesús Pinto-Medel, Mari Mar Mendibe, Nestor Acosta, Begoña Oliver, Miguel Guerrero, Marcos Papais-Alvarenga, Victoria Fernández-Sánchez, Laura Leyva. (2009) HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain). Journal of Neurology 256:12, 1977-1988
CrossRef238
Maarten E. Witte, John G.J.M. Bol, Wouter H. Gerritsen, Paul van der Valk, Benjamin Drukarch, Jack van Horssen, Micha M.M. Wilhelmus. (2009) Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions. Neurobiology of Disease 36:3, 445-452
CrossRef239
Y. Zhang, A. T. Argaw, B. T. Gurfein, A. Zameer, B. J. Snyder, C. Ge, Q. R. Lu, D. H. Rowitch, C. S. Raine, C. F. Brosnan, G. R. John. (2009) Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proceedings of the National Academy of Sciences 106:45, 19162-19167
CrossRef240
Ying Chen, Heng Wu, Shuzong Wang, Hisami Koito, Jianrong Li, Feng Ye, Jenny Hoang, Sabine S Escobar, Alexander Gow, Heather A Arnett, Bruce D Trapp, Nitin J Karandikar, Jenny Hsieh, Q Richard Lu. (2009) The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nature Neuroscience 12:11, 1398-1406
CrossRef241
Paul M Matthews, Robert Comley. (2009) Advances in the molecular imaging of multiple sclerosis. Expert Review of Clinical Immunology 5:6, 765-777
CrossRef242
Monika Bradl, Hans Lassmann. (2009) Progressive multiple sclerosis. Seminars in Immunopathology 31:4, 455-465
CrossRef243
Archana M. Jastorff, Katrin Haegler, Giuseppina Maccarrone, Florian Holsboer, Frank Weber, Tjalf Ziemssen, Christoph W. Turck. (2009) Regulation of proteins mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. PROTEOMICS
CLINICAL APPLICATIONS 3:11, 1273-1287
CrossRef244
Lucas Schirmer, Monika Albert, Armin Buss, Walter J. Schulz-Schaeffer, Jack P. Antel, Wolfgang Brück, Christine Stadelmann. (2009) Substantial early, but nonprogressive neuronal loss in multiple sclerosis (ms) spinal cord. Annals of Neurology 66:5, 698-704
CrossRef245
Darin T. Okuda. (2009) Unanticipated demyelinating pathology of the CNS. Nature Reviews Neurology 5:11, 591-597
CrossRef246
James C. Vickers, Anna E. King, Adele Woodhouse, Matthew T. Kirkcaldie, Jerome A. Staal, Graeme H. McCormack, Catherine A. Blizzard, Ruth E.J. Musgrove, Stanislaw Mitew, Yao Liu. (2009) Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system. Brain Research Bulletin 80:4-5, 217-223
CrossRef247
Anders A. F. Sima, Christopher R. Pierson, Randall L. Woltjer, Grace M. Hobson, Jeffrey A. Golden, William J. Kupsky, Galen M. Schauer, Thomas D. Bird, Robert P. Skoff, James Y. Garbern. (2009) Neuronal loss in Pelizaeus–Merzbacher disease differs in various mutations of the proteolipid protein 1. Acta Neuropathologica 118:4, 531-539
CrossRef248
Martha J. Miller, Cindy D. Kangas, Wendy B. Macklin. (2009) Neuronal expression of the proteolipid protein gene in the medulla of the mouse. Journal of Neuroscience Research 87:13, 2842-2853
CrossRef249
Julia M Edgar, Klaus-Armin Nave. (2009) The role of CNS glia in preserving axon function. Current Opinion in Neurobiology 19:5, 498-504
CrossRef250
Maarten E Witte, Lars Bø, Richard J Rodenburg, Jeroen A Belien, Rene Musters, Thierry Hazes, Liesbeth T Wintjes, Jan A Smeitink, Jeroen JG Geurts, Helga E De Vries, Paul van der Valk, Jack van Horssen. (2009) Enhanced number and activity of mitochondria in multiple sclerosis lesions. The Journal of Pathology 219:2, 193-204
CrossRef251
Gabriela Constantin, Silvia Marconi, Barbara Rossi, Stefano Angiari, Laura Calderan, Elena Anghileri, Beatrice Gini, Simone Dorothea Bach, Marianna Martinello, Francesco Bifari, Mirco Galiè, Ermanna Turano, Simona Budui, Andrea Sbarbati, Mauro Krampera, Bruno Bonetti. (2009) Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis. Stem Cells 27:10, 2624-2635
CrossRef252
G Comi, V Martinelli, M Rodegher, L Moiola, O Bajenaru, A Carra, I Elovaara, F Fazekas, HP Hartung, J Hillert, J King, S Komoly, C Lubetzki, X Montalban, KM Myhr, M Ravnborg, P Rieckmann, D Wynn, C Young, M Filippi. (2009) Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. The Lancet 374:9700, 1503-1511
CrossRef253
M. Trojano, F. Pellegrini, D. Paolicelli, A. Fuiani, G.B. Zimatore, C. Tortorella, I.L. Simone, F. Patti, A. Ghezzi, V. Zipoli, P. Rossi, C. Pozzilli, G. Salemi, A. Lugaresi, R. Bergamaschi, E. Millefiorini, M. Clerico, G. Lus, M. Vianello, C. Avolio, P. Cavalla, V. Lepore, P. Livrea, G. Comi, M.P. Amato, . (2009) Real-life impact of early interferon
CrossRef254
Benedetta Bodini, Zhaleh Khaleeli, Mara Cercignani, David H. Miller, Alan J. Thompson, Olga Ciccarelli. (2009) Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: An in vivo study with TBSS and VBM. Human Brain Mapping 30:9, 2852-2861
CrossRef255
Peter J Savino. (2009) Evaluation of the Retinal Nerve Fiber Layer: Descriptive or Predictive?. Journal of Neuro-Ophthalmology 29:3, 245-249
CrossRef256
S. Bittner, S. G. Meuth, K. Gobel, N. Melzer, A. M. Herrmann, O. J. Simon, A. Weishaupt, T. Budde, D. A. Bayliss, M. Bendszus, H. Wiendl. (2009) TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. Brain 132:9, 2501-2516
CrossRef257
Valentina Tomassini, Jacqueline Palace. (2009) Multiple sclerosis lesions: insights from imaging techniques. Expert Review of Neurotherapeutics 9:9, 1341-1359
CrossRef258
Kimmy G. Su, Gary Banker, Dennis Bourdette, Michael Forte. (2009) Axonal degeneration in multiple sclerosis: The mitochondrial hypothesis. Current Neurology and Neuroscience Reports 9:5, 411-417
CrossRef259
Mary K. Guyton, Saurav Brahmachari, Arabinda Das, Supriti Samantaray, Jun Inoue, Mitsuyoshi Azuma, Swapan K. Ray, Naren L. Banik. (2009) Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells. Journal of Neurochemistry 110:6, 1895-1907
CrossRef260
Mauricio F Farez, Francisco J Quintana, Roopali Gandhi, Guillermo Izquierdo, Miguel Lucas, Howard L Weiner. (2009) Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nature Immunology 10:9, 958-964
CrossRef261
Johannes Vogt, Friedemann Paul, Orhan Aktas, Kathrin Müller-Wielsch, Jan Dörr, Susanne Dörr, B. Suman Bharathi, Robert Glumm, Christoph Schmitz, Harry Steinbusch, Cedric S. Raine, Michael Tsokos, Robert Nitsch, Frauke Zipp. (2009) Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Annals of Neurology 66:3, 310-322
CrossRef262
Manuel A. Friese, Lars Fugger. (2009) Pathogenic CD8 + T cells in multiple sclerosis. Annals of Neurology 66:2, 132-141
CrossRef263
Hayrettin Tumani, Hans-Peter Hartung, Bernhard Hemmer, Charlotte Teunissen, Florian Deisenhammer, Gavin Giovannoni, Uwe K. Zettl. (2009) Cerebrospinal fluid biomarkers in multiple sclerosis. Neurobiology of Disease 35:2, 117-127
CrossRef264
Song Feng, Yin Hong, Zhang Zhou, Zhang JinSong, Dai XiaoFeng, Wang ZaiZhong, Ge YaLi, Liu Ying, Chang YingJuan, Huan Yi. (2009) Monitoring of acute axonal injury in the swine spinal cord with EAE by diffusion tensor imaging. Journal of Magnetic Resonance Imaging 30:2, 277-285
CrossRef265
Zografos Caramanos, Salvatore DiMaio, Sridar Narayanan, Yves Lapierre, Douglas L. Arnold. (2009) 1H-MRSI evidence for cortical gray matter pathology that is independent of cerebral white matter lesion load in patients with secondary progressive multiple sclerosis. Journal of the Neurological Sciences 282:1-2, 72-79
CrossRef266
Robert Zivadinov, Alireza Minagar. (2009) Evidence for gray matter pathology in multiple sclerosis: A neuroimaging approach. Journal of the Neurological Sciences 282:1-2, 1-4
CrossRef267
Dana Horakova, Michael G. Dwyer, Eva Havrdova, Jennifer L. Cox, Ondrej Dolezal, Niels Bergsland, Brett Rimes, Zdeněk Seidl, Manuela Vaneckova, Robert Zivadinov. (2009) Gray matter atrophy and disability progression in patients with early relapsing–remitting multiple sclerosisA 5-year longitudinal study. Journal of the Neurological Sciences 282:1-2, 112-119
CrossRef268
Maya N. Hatch, Chris S. Schaumburg, Thomas E. Lane, Hans S. Keirstead. (2009) Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. Journal of Neuroimmunology 212:1-2, 74-81
CrossRef269
Ulf Schulze-Topphoff, Alexandre Prat, Timour Prozorovski, Volker Siffrin, Magdalena Paterka, Josephine Herz, Ivo Bendix, Igal Ifergan, Ines Schadock, Marcelo A Mori, Jack Van Horssen, Friederike Schröter, Alina Smorodchenko, May Htwe Han, Michael Bader, Lawrence Steinman, Orhan Aktas, Frauke Zipp. (2009) Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nature Medicine 15:7, 788-793
CrossRef270
Michael A. Henry, Songjiang Luo, Benjamin D. Foley, Rachael S. Rzasa, Lonnie R. Johnson, S. Rock Levinson. (2009) Sodium Channel Expression and Localization at Demyelinated Sites in Painful Human Dental Pulp. The Journal of Pain 10:7, 750-758
CrossRef271
Jason G. Weinger, Kakuri M. Omari, Kurt Marsden, Cedric S. Raine, Bridget Shafit-Zagardo. (2009) Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions. The American Journal of Pathology 175:1, 283-293
CrossRef272
D. Kremer, A. Heinen, J. Jadasz, P. Gottle, K. Zimmermann, P. Zickler, S. Jander, H.-P. Hartung, P. Kury. (2009) p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation. Proceedings of the National Academy of Sciences 106:22, 9087-9092
CrossRef273
Giancarlo Comi. (2009) Shifting the paradigm toward earlier treatment of multiple sclerosis with interferon beta. Clinical Therapeutics 31:6, 1142-1157
CrossRef274
David Azoulay, Karin Mausner-Fainberg, Nataly Urshansky, Firas Fahoum, Arnon Karni. (2009) Interferon-β therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism. Journal of Neuroimmunology 211:1-2, 114-119
CrossRef275
Declan Chard, David Miller. (2009) Is multiple sclerosis a generalized disease of the central nervous system? An MRI perspective. Current Opinion in Neurology 22:3, 214-218
CrossRef276
T. Derfuss, K. Parikh, S. Velhin, M. Braun, E. Mathey, M. Krumbholz, T. Kumpfel, A. Moldenhauer, C. Rader, P. Sonderegger, W. Pollmann, C. Tiefenthaller, J. Bauer, H. Lassmann, H. Wekerle, D. Karagogeos, R. Hohlfeld, C. Linington, E. Meinl. (2009) From the Cover: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences 106:20, 8302-8307
CrossRef277
J. M. Frischer, S. Bramow, A. Dal-Bianco, C. F. Lucchinetti, H. Rauschka, M. Schmidbauer, H. Laursen, P. S. Sorensen, H. Lassmann. (2009) The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 132:5, 1175-1189
CrossRef278
D. J. Mahad, I. Ziabreva, G. Campbell, N. Lax, K. White, P. S. Hanson, H. Lassmann, D. M. Turnbull. (2009) Mitochondrial changes within axons in multiple sclerosis. Brain 132:5, 1161-1174
CrossRef279
V. Andreoli, F. Trecroci, A. La Russa, P. Valentino, F. Condino, V. Latorre, R. Nisticò, D. Pirritano, F. Del Giudice, M. Canino, R. Cittadella, A. Quattrone. (2009) CASP-9: A susceptibility locus for multiple sclerosis in Italy. Journal of Neuroimmunology 210:1-2, 100-103
CrossRef280
Thomas G Forsthuber, Paolo Muraro. (2009) Is there a place for ‘immuno’ in the immunotherapy of multiple sclerosis?. Immunotherapy 1:3, 329-331
CrossRef281
E. C. Tallantyre, L. Bo, O. Al-Rawashdeh, T. Owens, C. H. Polman, J. Lowe, N. Evangelou. (2009) Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease. Brain 132:5, 1190-1199
CrossRef282
A. Kalyvas, C. Baskakis, V. Magrioti, V. Constantinou-Kokotou, D. Stephens, R. Lopez-Vales, J.-Q. Lu, V. W. Yong, E. A. Dennis, G. Kokotos, S. David. (2009) Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain 132:5, 1221-1235
CrossRef283
Jane Marian Anderson, Rickie Patani, Richard Reynolds, Richard Nicholas, Alastair Compston, Maria Grazia Spillantini, Siddharthan Chandran. (2009) Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis. Acta Neuropathologica 117:5, 583-589
CrossRef284
Issa P Bagayogo, Cheryl F Dreyfus. (2009) Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway. ASN NEURO 1:1, 1-12
CrossRef285
S.G. Meuth, N. Melzer, C. Kleinschnitz, T. Budde, H. Wiendl. (2009) Multiple Sklerose – eine Kanalopathie?. Der Nervenarzt 80:4, 422-429
CrossRef286
Scott Kolbe, Caron Chapman, Thanh Nguyen, Clare Bajraszewski, Leigh Johnston, Michael Kean, Peter Mitchell, Mark Paine, Helmut Butzkueven, Trevor Kilpatrick, Gary Egan. (2009) Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis. NeuroImage 45:3, 679-686
CrossRef287
Alexander Klistorner, H. Arvind, T. Nguyen, R. Garrick, M. Paine, S. Graham, J. O’Day, C. Yiannikas. (2009) Multifocal VEP and OCT in optic neuritis: a topographical study of the structure–function relationship. Documenta Ophthalmologica 118:2, 129-137
CrossRef288
Dimitrios Papadopoulos, Sumayya Dukes, Ryan Patel, Richard Nicholas, Abhilash Vora, Richard Reynolds. (2009) Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis. Brain Pathology 19:2, 238-253
CrossRef289
Aimee Pasqua Borazanci, Meghan K Harris, Robert N Schwendimann, Eduardo Gonzalez-Toledo, Amir H Maghzi, Masoud Etemadifar, Nadejda Alekseeva, James Pinkston, Roger E Kelley, Alireza Minagar. (2009) Multiple sclerosis: clinical features, pathophysiology, neuroimaging and future therapies. Future Neurology 4:2, 229-246
CrossRef290
Abbas Mirshafiey, Monireh Mohsenzadegan. (2009) Antioxidant therapy in multiple sclerosis. Immunopharmacology and Immunotoxicology 31:1, 13-29
CrossRef291
Dagmara Mirowska-Guzel. (2009) The role of neurotrophic factors in the pathology and treatment of multiple sclerosis. Immunopharmacology and Immunotoxicology 31:1, 32-38
CrossRef292
JC Álvarez-Cermeño, T Gasalla, LM Villar. (2009) Increased soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis and CNS inflammation. Future Neurology 4:2, 149-151
CrossRef293
N. García-Barragán, L. M. Villar, M. Espiño, M. C. Sádaba, P. González-Porqué, J. C. Álvarez-Cermeño. (2009) Multiple sclerosis patients with anti-lipid oligoclonal IgM show early favourable response to immunomodulatory treatment. European Journal of Neurology 16:3, 380-385
CrossRef294
Eitan Okun, Kathleen J. Griffioen, Justin D. Lathia, Sung-Chun Tang, Mark P. Mattson, Thiruma V. Arumugam. (2009) Toll-like receptors in neurodegeneration. Brain Research Reviews 59:2, 278-292
CrossRef295
M. Kerschensteiner, E. Meinl, R. Hohlfeld. (2009) Neuro-immune crosstalk in CNS diseases. Neuroscience 158:3, 1122-1132
CrossRef296
F. Piehl, T. Olsson. (2009) Inflammation and susceptibility to neurodegeneration: The use of unbiased genetics to decipher critical regulatory pathways. Neuroscience 158:3, 1143-1150
CrossRef297
B SAJJA, J WOLINSKY, P NARAYANA. (2009) Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis. Neuroimaging Clinics of North America 19:1, 45-58
CrossRef298
Jeffrey A. Cohen. (2009) The future of multiple sclerosis treatment. Journal of the Neurological Sciences 277, S55-S61
CrossRef299
Monica Montes, Xin Zhang, Laureline Berthelot, David-Axel Laplaud, Sophie Brouard, Jianping Jin, Sarah Rogan, Diane Armao, Valerie Jewells, Jean-Paul Soulillou, Silva Markovic-Plese. (2009) Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. Clinical Immunology 130:2, 133-144
CrossRef300
Jian-Qiang Lu, Yan Fan, Alim P. Mitha, Robert Bell, Luanne Metz, G. R. Wayne Moore, V. Wee Yong. (2009) Association of α-Synuclein Immunoreactivity With Inflammatory Activity in Multiple Sclerosis Lesions. Journal of Neuropathology and Experimental Neurology 68:2, 179-189
CrossRef301
D.P. Ankeny, P.G. Popovich. (2009) Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury. Neuroscience 158:3, 1112-1121
CrossRef302
M. Vercellino, A. Romagnolo, A. Mattioda, S. Masera, C. Piacentino, A. Merola, A. Chiò, R. Mutani, P. Cavalla. (2009) Multiple sclerosis relapses: a multivariable analysis of residual disability determinants. Acta Neurologica Scandinavica 119:2, 126-130
CrossRef303
C GLISSON, S GALETTA. (2009) Nonconventional Optic Nerve Imaging in Multiple Sclerosis. Neuroimaging Clinics of North America 19:1, 71-79
CrossRef304
K BRIDGE, N BERG, R ADALBERT, E BABETTO, T DIAS, M SPILLANTINI, R RIBCHESTER, M COLEMAN. (2009) Late onset distal axonal swelling in YFP-H transgenic mice. Neurobiology of Aging 30:2, 309-321
CrossRef305
Jack Rosenbluth, Rolf Schiff, Pokman Lam. (2009) Effects of osmolality on PLP-null myelin structure: Implications re axon damage. Brain Research 1253, 191-197
CrossRef306
Nathalie Koning, Dick F. Swaab, Robert M. Hoek, Inge Huitinga. (2009) Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions. Journal of Neuropathology and Experimental Neurology 68:2, 159-167
CrossRef307
Farshid Noorbakhsh, Christopher M. Overall, Christopher Power. (2009) Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology. Trends in Neurosciences 32:2, 88-100
CrossRef308
Mohamed Ouardouz, Elaine Coderre, Gerald W. Zamponi, Shameed Hameed, Xinghua Yin, Bruce D. Trapp, Peter K. Stys. (2009) Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Annals of Neurology 65:2, 160-166
CrossRef309
Mohamed Ouardouz, Elaine Coderre, Ajoy Basak, Andrew Chen, Gerald W. Zamponi, Shameed Hameed, Renata Rehak, Xinghua Yin, Bruce D. Trapp, Peter K. Stys. (2009) Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors. Annals of Neurology 65:2, 151-159
CrossRef310
Lorenzo De Santi, Loredana Cantalupo, Maristella Tassi, Donatella Raspadori, Chiara Cioni, Pasquale Annunziata. (2009) Higher expression of BDNF receptor gp145trkB is associated with lower apoptosis intensity in T cell lines in multiple sclerosis. Journal of the Neurological Sciences 277:1-2, 65-70
CrossRef311
I VAVASOUR, C LAULE, D LI, J OGER, G MOORE, A TRABOULSEE, A MACKAY. (2009) Longitudinal changes in myelin water fraction in two MS patients with active disease. Journal of the Neurological Sciences 276:1-2, 49-53
CrossRef312
Jin Shijie, Hideyuki Takeuchi, Izumi Yawata, Yohei Harada, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Li Hua, Satoko Yasuoka, Yan Zhou, Mariko Noda, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumura. (2009) Blockade of Glutamate Release from Microglia Attenuates Experimental Autoimmune Encephalomyelitis in Mice. The Tohoku Journal of Experimental Medicine 217:2, 87-92
CrossRef313
Hans Kretzschmar. (2009) Brain banking: opportunities, challenges and meaning for the future. Nature Reviews Neuroscience 10:1, 70-78
CrossRef314
Ben W. Thrower. (2009) Relapse Management in Multiple Sclerosis. The Neurologist 15:1, 1-5
CrossRef315
Øivind Torkildsen, Linn Anne Brunborg, Frits Thorsen, Sverre Jarl Mørk, Martin Stangel, Kjell-Morten Myhr, Lars Bø. (2009) Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination. Experimental Neurology 215:1, 160-166
CrossRef316
Hye-Sun Kim, Yoo-Hun Suh. (2009) Minocycline and neurodegenerative diseases. Behavioural Brain Research 196:2, 168-179
CrossRef317
Massimo A. Hilliard. (2009) Axonal degeneration and regeneration: a mechanistic tug-of-war. Journal of Neurochemistry 108:1, 23-32
CrossRef318
Woojun Kim, Ho Jin Kim. (2009) Multiple Sclerosis. Journal of the Korean Medical Association 52:7, 665
CrossRef319
Jin Nakahara, Kohsuke Kanekura, Mikiro Nawa, Sadakazu Aiso, Norihiro Suzuki. (2008) Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. Journal of Clinical Investigation
CrossRef320
Sriram Ramanan, Mitra Kooshki, Weiling Zhao, Fang-Chi Hsu, Mike E. Robbins. (2008) PPARα ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-κB and AP-1 pathways. Free Radical Biology and Medicine 45:12, 1695-1704
CrossRef321
L. Cucurachi, P. Immovilli, F. Granella, G. Pavesi, L. Cattaneo. (2008) Short-latency afferent inhibition predicts verbal memory performance in patients with multiple sclerosis. Journal of Neurology 255:12, 1949-1956
CrossRef322
D. Mahad, H. Lassmann, D. Turnbull. (2008) Review: Mitochondria and disease progression in multiple sclerosis. Neuropathology and Applied Neurobiology 34:6, 577-589
CrossRef323
Ruth Huizinga, Wouter Gerritsen, Nicole Heijmans, Sandra Amor. (2008) Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments. Neurobiology of Disease 32:3, 461-470
CrossRef324
Melissa M. Gresle, Gerry Shaw, Bevyn Jarrott, Estella N. Alexandrou, Anna Friedhuber, Trevor J. Kilpatrick, Helmut Butzkueven. (2008) Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 86:16, 3548-3555
CrossRef325
I HAMANN, F ZIPP, C INFANTEDUARTE. (2008) Therapeutic targeting of chemokine signaling in Multiple Sclerosis. Journal of the Neurological Sciences 274:1-2, 31-38
CrossRef326
D. T. Okuda, R. Srinivasan, J. R. Oksenberg, D. S. Goodin, S. E. Baranzini, A. Beheshtian, E. Waubant, S. S. Zamvil, D. Leppert, P. Qualley, R. Lincoln, R. Gomez, S. Caillier, M. George, J. Wang, S. J. Nelson, B. A. C. Cree, S. L. Hauser, D. Pelletier. (2008) Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain 132:1, 250-259
CrossRef327
Chun Shui Yu, Fu Chun Lin, Yaou Liu, Yunyun Duan, Hao Lei, Kun Cheng Li. (2008) Histogram analysis of diffusion measures in clinically isolated syndromes and relapsing-remitting multiple sclerosis. European Journal of Radiology 68:2, 328-334
CrossRef328
Ikuo Tsunoda. (2008) Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. Future Virology 3:6, 579-593
CrossRef329
Elliot M. Frohman, Todd Eagar, Nancy Monson, Olaf Stuve, Nitin Karandikar. (2008) Immunologic Mechanisms of Multiple Sclerosis. Neuroimaging Clinics of North America 18:4, 577-588
CrossRef330
Antonio Giorgio, Marco Battaglini, Stephen M. Smith, Nicola De Stefano. (2008) Brain Atrophy Assessment in Multiple Sclerosis: Importance and Limitations. Neuroimaging Clinics of North America 18:4, 675-686
CrossRef331
Rocio S. Lopez-Diego, Howard L. Weiner. (2008) Novel therapeutic strategies for multiple sclerosis — a multifaceted adversary. Nature Reviews Drug Discovery 7:11, 909-925
CrossRef332
Anthony Traboulsee, David K.B. Li. (2008) Conventional MR Imaging. Neuroimaging Clinics of North America 18:4, 651-673
CrossRef333
Cristina Maria Costantino, Clare Baecher-Allan, David A. Hafler. (2008) Multiple Sclerosis and Regulatory T Cells. Journal of Clinical Immunology 28:6, 697-706
CrossRef334
D KARUSSIS, I KASSIS. (2008) The potential use of stem cells in multiple sclerosis: An overview of the preclinical experience. Clinical Neurology and Neurosurgery 110:9, 889-896
CrossRef335
Hans Lassmann. (2008) The Pathologic Substrate of Magnetic Resonance Alterations in Multiple Sclerosis. Neuroimaging Clinics of North America 18:4, 563-576
CrossRef336
E GRAY, T THOMAS, S BETMOUNI, N SCOLDING, S LOVE. (2008) Elevated myeloperoxidase activity in white matter in multiple sclerosis. Neuroscience Letters 444:2, 195-198
CrossRef337
Charles H. Bombardier, Mary Cunniffe, Rohini Wadhwani, Laura E. Gibbons, Kimberly D. Blake, George H. Kraft. (2008) The Efficacy of Telephone Counseling for Health Promotion in People With Multiple Sclerosis: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation 89:10, 1849-1856
CrossRef338
Richard A Rudick, Sha Mi, Alfred W Sandrock. (2008) LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence. Expert Opinion on Biological Therapy 8:10, 1561-1570
CrossRef339
Elisabetta Vegeto, Valeria Benedusi, Adriana Maggi. (2008) Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases. Frontiers in Neuroendocrinology 29:4, 507-519
CrossRef340
Alastair Compston, Alasdair Coles. (2008) Multiple sclerosis. The Lancet 372:9648, 1502-1517
CrossRef341
Axel Petzold, Djordje Gveric, Mike Groves, Klaus Schmierer, Donna Grant, Miles Chapman, Geoffrey Keir, Louise Cuzner, Edward J. Thompson. (2008) Phosphorylation and compactness of neurofilaments in multiple sclerosis: Indicators of axonal pathology. Experimental Neurology 213:2, 326-335
CrossRef342
Shigeki Tsutsui, Jennifer N. Hahn, Trina A. Johnson, Zenobia Ali, Frank R. Jirik. (2008) Absence of the Cellular Prion Protein Exacerbates and Prolongs Neuroinflammation in Experimental Autoimmune Encephalomyelitis. The American Journal of Pathology 173:4, 1029-1041
CrossRef343
J. Wu, M. Ohlsson, E.A. Warner, K.K. Loo, T.X. Hoang, R.R. Voskuhl, L.A. Havton. (2008) Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis. Neuroscience 156:3, 586-596
CrossRef344
Tamir Ben-Hur, Steven A. Goldman. (2008) Prospects of Cell Therapy for Disorders of Myelin. Annals of the New York Academy of Sciences 1142:1, 218-249
CrossRef345
Getaw Worku Hassen, Jason Feliberti, Leo Kesner, Alfred Stracher, Foroozan Mokhtarian. (2008) Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis. Brain Research 1236, 206-215
CrossRef346
Alexander Klistorner, Hemamalini Arvind, Than Nguyen, Raymond Garrick, Mark Paine, Stuart Graham, Justin O'Day, John Grigg, Francis Billson, Con Yiannikas. (2008) Axonal loss and myelin in early ON loss in postacute optic neuritis. Annals of Neurology 64:3, 325-331
CrossRef347
Leonora K. Fisniku, Declan T. Chard, Jonathan S. Jackson, Valerie M. Anderson, Daniel R. Altmann, Katherine A. Miszkiel, Alan J. Thompson, David H. Miller. (2008) Gray matter atrophy is related to long-term disability in multiple sclerosis. Annals of Neurology 64:3, 247-254
CrossRef348
Andrei Blokhin, Tamara Vyshkina, Samuel Komoly, Bernadette Kalman. (2008) Lack of Mitochondrial DNA Deletions in Lesions of Multiple Sclerosis. NeuroMolecular Medicine 10:3, 187-194
CrossRef349
C. Infante-Duarte, S. Waiczies, J. Wuerfel, F. Zipp. (2008) New developments in understanding and treating neuroinflammation. Journal of Molecular Medicine 86:9, 975-985
CrossRef350
Mark S. Freedman. (2008) Induction vs. escalation of therapy for relapsing Multiple Sclerosis: the evidence. Neurological Sciences 29:S2, 250-252
CrossRef351
Meghann Teague Getts, Daniel R Getts, Adam P Kohm, Stephen D Miller. (2008) Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis. Therapy 5:5, 631-640
CrossRef352
Kenneth S. Shindler, Elvira Ventura, Mahasweta Dutt, Abdolmohamad Rostami. (2008) Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Experimental Eye Research 87:3, 208-213
CrossRef353
Albert Lo. (2008) Advancement of therapies for neuroprotection in multiple sclerosis. Expert Review of Neurotherapeutics 8:9, 1355-1366
CrossRef354
A. Chang, M. C. Smith, X. Yin, R. J. Fox, S. M. Staugaitis, B. D. Trapp. (2008) Neurogenesis in the chronic lesions of multiple sclerosis. Brain 131:9, 2366-2375
CrossRef355
Xiaoming Gong, Tong Lin, Zhaohui Sun, Min Fu, Huancong Zuo, Zuoping Xie. (2008) Olig1 is downregulated in oligodendrocyte progenitor cell differentiation. NeuroReport 19:12, 1203-1207
CrossRef356
Tamara Vyshkina, Bernadette Kalman. (2008) Autoantibodies and neurodegeneration in multiple sclerosis. Laboratory Investigation 88:8, 796-807
CrossRef357
T MAKAR, D TRISLER, K SURA, S SULTANA, N PATEL, C BEVER. (2008) Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. Journal of the Neurological Sciences 270:1-2, 70-76
CrossRef358
Jane Castelli-Haley, Merry-Kay A. Oleen-Burkey, Maureen J. Lage, Kenneth P. Johnson. (2008) Glatiramer acetate versus interferon beta-1a for subcutaneous administration: Comparison of outcomes among multiple sclerosis patients. Advances in Therapy 25:7, 658-673
CrossRef359
Klaus-Armin Nave, Bruce D. Trapp. (2008) Axon-Glial Signaling and the Glial Support of Axon Function. Annual Review of Neuroscience 31:1, 535-561
CrossRef360
K. Mitosek-Szewczyk, G. Sulkowski, Z. Stelmasiak, L. Strużyńska. (2008) Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis. Neuroscience 155:1, 45-52
CrossRef361
Hayrettin Tumani, Charlotte Teunissen, Sigurd Süssmuth, Markus Otto, Albert C Ludolph, Johannes Brettschneider. (2008) Cerebrospinal fluid biomarkers of neurodegeneration in chronic neurological diseases. Expert Review of Molecular Diagnostics 8:4, 479-494
CrossRef362
Bruce D. Trapp, Klaus-Armin Nave. (2008) Multiple Sclerosis: An Immune or Neurodegenerative Disorder?. Annual Review of Neuroscience 31:1, 247-269
CrossRef363
M. Bester, C. Heesen, S. Schippling, R. Martin, X.-Q. Ding, B. Holst, J. Fiehler. (2008) Early anisotropy changes in the corpus callosum of patients with optic neuritis. Neuroradiology 50:7, 549-557
CrossRef364
J. M. Anderson, D. W. Hampton, R. Patani, G. Pryce, R. A. Crowther, R. Reynolds, R. J. M. Franklin, G. Giovannoni, D. A. S. Compston, D. Baker, M. G. Spillantini, S. Chandran. (2008) Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain 131:7, 1736-1748
CrossRef365
Mark J. Lowe, Erik B. Beall, Ken E. Sakaie, Katherine A. Koenig, Lael Stone, Ruth Ann Marrie, Micheal D. Phillips. (2008) Resting state sensorimotor functional connectivity in multiple sclerosis inversely correlates with transcallosal motor pathway transverse diffusivity. Human Brain Mapping 29:7, 818-827
CrossRef366
Nuhad Abou Zeid, M Tariq Bhatti. (2008) Acute Inflammatory Demyelinating Optic Neuritis. The Neurologist 14:4, 207-223
CrossRef367
Tracy DeAngelis, Fred Lublin. (2008) Multiple sclerosis: new treatment trials and emerging therapeutic targets. Current Opinion in Neurology 21:3, 261-271
CrossRef368
Keisuke Ishizawa, Takashi Komori, Nobutaka Arai, Toshio Mizutani, Takanori Hirose. (2008) Glial cytoplasmic inclusions and tissue injury in multiple system atrophy: A quantitative study in white matter (olivopontocerebellar system) and gray matter (nigrostriatal system). Neuropathology 28:3, 249-257
CrossRef369
R. H. B. Benedict, J. L. Shucard, R. Zivadinov, D. W. Shucard. (2008) Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis. Neuropsychology Review 18:2, 149-166
CrossRef370
Vittorio Gallo, Regina C Armstrong. (2008) Myelin repair strategies: a cellular view. Current Opinion in Neurology 21:3, 278-283
CrossRef371
Bong-Il Kim, Ki-Hong Kim, Hwa-Shik Youn, Sanghoon Jheon, Jong-Ki Kim, Hongtae Kim. (2008) High resolution X-ray phase contrast synchrotron imaging of normal and ligation damaged rat sciatic nerves. Microscopy Research and Technique 71:6, 443-447
CrossRef372
K HEINNEEMAIER, A KOHLER, R DIEM, M SATTLER, I DEMMER, P LANGE, M BAHR, M OTTO. (2008) Biological markers for axonal degeneration in CSF and blood of patients with the first event indicative for multiple sclerosis. Neuroscience Letters 436:1, 72-76
CrossRef373
Radmila Filipovic, Nada Zecevic. (2008) Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia. Experimental Neurology 211:1, 41-51
CrossRef374
Eva Herrero-Herranz, Luis A. Pardo, Ralf Gold, Ralf A. Linker. (2008) Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: Implications for multiple sclerosis. Neurobiology of Disease 30:2, 162-173
CrossRef375
Pamela A. Carpentier, Meghann Teague Getts, Stephen D. Miller. (2008) Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease. Virology 375:1, 24-36
CrossRef376
Elizabeth A. Young, Christie D. Fowler, Grahame J. Kidd, Ansi Chang, Richard Rudick, Elizabeth Fisher, Bruce D. Trapp. (2008) Imaging correlates of decreased axonal Na + /K + ATPase in chronic multiple sclerosis lesions. Annals of Neurology 63:4, 428-435
CrossRef377
A Meini, C Sticozzi, L Massai, M Palmi. (2008) A nitric oxide/Ca 2+ /calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1β in human astrocytoma cells. British Journal of Pharmacology 153:8, 1706-1717
CrossRef378
Katrin Hoffmann, Maren Lindner, Ina Gröticke, Martin Stangel, Wolfgang Löscher. (2008) Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice. Experimental Neurology 210:2, 308-321
CrossRef379
David Azoulay, Natali Urshansky, Arnon Karni. (2008) Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. Journal of Neuroimmunology 195:1-2, 186-193
CrossRef380
Stephen G Waxman. (2008) Mechanisms of Disease: sodium channels and neuroprotection in multiple sclerosis—current status. Nature Clinical Practice Neurology 4:3, 159-169
CrossRef381
Olaf Stüve, Petra D Cravens, Todd N Eagar. (2008) DNA-based vaccines: the future of multiple sclerosis therapy?. Expert Review of Neurotherapeutics 8:3, 351-360
CrossRef382
Tracy DeAngelis, Fred Lublin. (2008) Neurotherapeutics in multiple sclerosis: Novel agents and emerging treatment strategies. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 75:2, 157-167
CrossRef383
Mar Tintoré. (2008) Rationale for early intervention with immunomodulatory treatments. Journal of Neurology 255:S1, 37-43
CrossRef384
Silva Markovic-Plese, Avtar K Singh, Inderjit Singh. (2008) Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair. Future Neurology 3:2, 153-167
CrossRef385
Felipe A. Court, Peter J. Brophy, Richard R. Ribchester. (2008) Remodeling of motor nerve terminals in demyelinating axons of periaxin-null mice. Glia 56:4, 471-479
CrossRef386
Nicolas Couturier, Jacques P. Zappulla, Valérie Lauwers-Cances, Emmanuelle Uro-Coste, Marie-Bernadette Delisle, Michel Clanet, Lisette Montagne, Paul Van der Valk, Lars Bö, Roland S. Liblau. (2008) Mast cell transcripts are increased within and outside multiple sclerosis lesions. Journal of Neuroimmunology 195:1-2, 176-185
CrossRef387
Olatz Pampliega, María Domercq, Pablo Villoslada, Jorge Sepulcre, Alfredo Rodríguez-Antigüedad, Carlos Matute. (2008) Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. Journal of Neuroimmunology 195:1-2, 194-198
CrossRef388
G COMI. (2008) Is it clinically relevant to repair focal multiple sclerosis lesions?. Journal of the Neurological Sciences 265:1-2, 17-20
CrossRef389
T GLASER, T SCHMANDT, O BRUSTLE. (2008) Generation and potential biomedical applications of embryonic stem cell-derived glial precursors. Journal of the Neurological Sciences 265:1-2, 47-58
CrossRef390
R HOHLFELD. (2008) Neurotrophic cross-talk between the nervous and immune systems: Relevance for repair strategies in multiple sclerosis?
. Journal of the Neurological Sciences 265:1-2, 93-96
CrossRef391
D KARUSSIS, I KASSIS, B KURKALLI, S SLAVIN. (2008) Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): A proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases
CrossRef392
Teresa G. D'Aversa, Eliseo A. Eugenin, Joan W. Berman. (2008) CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-κB (NFκB) and activator protein-1 (AP-1). Journal of Neuroscience Research 86:3, 630-639
CrossRef393
Steven P. Templeton, Stanley Perlman. (2008) Role of IFN-γ responsiveness in CD8 T cell-mediated viral clearance and demyelination in coronavirus-infected mice. Journal of Neuroimmunology 194:1-2, 18-26
CrossRef394
R. Zivadinov, A.C. Banas, V. Yella, N. Abdelrahman, B. Weinstock-Guttman, M.G. Dwyer. (2008) Comparison of Three Different Methods for Measurement of Cervical Cord Atrophy in Multiple Sclerosis. American Journal of Neuroradiology 29:2, 319-325
CrossRef395
Klaus Schmierer, Claudia A.M. Wheeler-Kingshott, Daniel J. Tozer, Phil A. Boulby, Harold G. Parkes, Tarek A. Yousry, Francesco Scaravilli, Gareth J. Barker, Paul S. Tofts, David H. Miller. (2008) Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation. Magnetic Resonance in Medicine 59:2, 268-277
CrossRef396
Zhongwu Liu, Yi Li, Jing Zhang, Stanton Elias, Michael Chopp. (2008) Evaluation of corticospinal axon loss by fluorescent dye tracing in mice with experimental autoimmune encephalomyelitis. Journal of Neuroscience Methods 167:2, 191-197
CrossRef397
K. A. Irvine, W. F. Blakemore. (2008) Remyelination protects axons from demyelination-associated axon degeneration. Brain 131:6, 1464-1477
CrossRef398
S. Chandran, D. Hunt, A. Joannides, C. Zhao, A. Compston, R. J.M Franklin. (2008) Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philosophical Transactions of the Royal Society B: Biological Sciences 363:1489, 171-183
CrossRef399
Muriel B. Sättler, Mauro Togni, Ivana Gadjanski, Kurt-Wolfram Sühs, Nadine Meyer, Mathias Bähr, Ricarda Diem. (2008) Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis. Journal of Neuroimmunology 193:1-2, 77-86
CrossRef400
Arévalo-Martín, D García-Ovejero, O Gómez, A Rubio-Araiz, B Navarro-Galve, C Guaza, E Molina-Holgado, F Molina-Holgado. (2008) CB 2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies. British Journal of Pharmacology 153:2, 216-225
CrossRef401
Til Menge, Martin S Weber, Bernhard Hemmer, Bernd C Kieseier, Hans-Christian von Büdingen, Clemens Warnke, Scott S Zamvil, Aaron Boster, Omar Khan, Hans-Peter Hartung, Olaf Stüve. (2008) Disease-Modifying Agents for Multiple Sclerosis. Drugs 68:17, 2445-2468
CrossRef402
Steven P. Templeton, Taeg S. Kim, Katherine O'Malley, Stanley Perlman. (2008) Maturation and Localization of Macrophages and Microglia During Infection with a Neurotropic Murine Coronavirus. Brain Pathology 18:1, 40-51
CrossRef403
Christopher Christodoulou, William S MacAllister, Nancy A McLinskey, Lauren B Krupp. (2008) Treatment of Cognitive Impairment in??Multiple Sclerosis. CNS Drugs 22:2, 87-97
CrossRef404
Arthur A Vandenbark, Rivka Abulafia-Lapid. (2008) Autologous T-Cell Vaccination for Multiple Sclerosis. BioDrugs 22:4, 265-273
CrossRef405
Robert C. Sergott, Elliot Frohman, Robert Glanzman, Ahmad AL-Sabbagh. (2007) The role of optical coherence tomography in multiple sclerosis: Expert panel consensus
CrossRef406
Cui P. Chen, Mary E. Kiel, Dorota Sadowski, Randall D. McKinnon. (2007) From Stem Cells to Oligodendrocytes: Prospects for Brain Therapy. Stem Cell Reviews 3:4, 280-288
CrossRef407
Manuel A Friese, Matthew J Craner, Ruth Etzensperger, Sandra Vergo, John A Wemmie, Michael J Welsh, Angela Vincent, Lars Fugger. (2007) Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nature Medicine 13:12, 1483-1489
CrossRef408
Niklas Mattsson, Ulla Rüetschi, Vladimir N. Podust, Mats Stridsberg, Susann Li, Oluf Andersen, Sara Haghighi, Kaj Blennow, Henrik Zetterberg. (2007) Cerebrospinal fluid concentrations of peptides derived from chromogranin B and secretogranin II are decreased in multiple sclerosis. Journal of Neurochemistry 103:5, 1932-1939
CrossRef409
Shijie Jin, Jun Kawanokuchi, Tetsuya Mizuno, Jinyan Wang, Yoshifumi Sonobe, Hideyuki Takeuchi, Akio Suzumura. (2007) Interferon-β is neuroprotective against the toxicity induced by activated microglia. Brain Research 1179, 140-146
CrossRef410
Stella Elkabes, Hong Li. (2007) Proteomic strategies in multiple sclerosis and its animal models. PROTEOMICS – CLINICAL APPLICATIONS 1:11, 1393-1405
CrossRef411
D.S. Meier, H.L. Weiner, C.R.G. Guttmann. (2007) MR Imaging Intensity Modeling of Damage and Repair In Multiple Sclerosis: Relationship of Short-Term Lesion Recovery to Progression and Disability. American Journal of Neuroradiology 28:10, 1956-1963
CrossRef412
Robert H Miller, Sha Mi. (2007) Dissecting demyelination. Nature Neuroscience 10:11, 1351-1354
CrossRef413
Sha Mi, Bing Hu, Kyungmin Hahm, Yi Luo, Edward Sai Kam Hui, Qiuju Yuan, Wai Man Wong, Li Wang, Huanxing Su, Tak-Ho Chu, Jiasong Guo, Wenming Zhang, Kwok-Fai So, Blake Pepinsky, Zhaohui Shao, Christilyn Graff, Ellen Garber, Vincent Jung, Ed Xuekui Wu, Wutian Wu. (2007) LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Medicine 13:10, 1228-1233
CrossRef414
Ikuo Tsunoda, Tomoko Tanaka, Yukio Saijoh, Robert S. Fujinami. (2007) Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration. The American Journal of Pathology 171:5, 1563-1575
CrossRef415
Qizhu Wu, Helmut Butzkueven, Melissa Gresle, Frank Kirchhoff, Anna Friedhuber, Qing Yang, Hong Wang, Ke Fang, Hao Lei, Gary F. Egan, Trevor J. Kilpatrick. (2007) MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. NeuroImage 37:4, 1138-1147
CrossRef416
Elisabet Reyes-Irisarri, Antonio J. Sánchez, Juan Antonio García-Merino, Guadalupe Mengod. (2007) Selective Induction of cAMP Phosphodiesterase PDE4B2 Expression in Experimental Autoimmune Encephalomyelitis. Journal of Neuropathology and Experimental Neurology 66:10, 923-931
CrossRef417
C. Münch, R. Meyer, P. Linke, T. Meyer, A.C. Ludolph, J. Haas, B. Hemmer. (2007) The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis. Acta Neurologica Scandinavica 116:4, 231-234
CrossRef418
Shu-Wei Sun, Hsiao-Fang Liang, Robert E. Schmidt, Anne H. Cross, Sheng-Kwei Song. (2007) Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging. Neurobiology of Disease 28:1, 30-38
CrossRef419
C CUDRICI, T ITO, E ZAFRANSKAIA, F NICULESCU, K MULLEN, S VLAICU, S JUDGE, P CALABRESI, H RUS. (2007) Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis. Experimental and Molecular Pathology 83:2, 198-206
CrossRef420
M.A. Rocca, T. Mondria, P. Valsasina, M.P. Sormani, Z.H. Flach, P.A. Te Boekhorst, G. Comi, R.Q. Hintzen, M. Filippi. (2007) A Three-Year Study of Brain Atrophy after Autologous Hematopoietic Stem Cell Transplantation in Rapidly Evolving Secondary Progressive Multiple Sclerosis. American Journal of Neuroradiology 28:9, 1659-1661
CrossRef421
Tineke van Veen, Jessica Nielsen, Johannes Berkhof, Frederik Barkhof, Wouter Kamphorst, Lars Bö, Rivka Ravid, Cor L. Verweij, Inge Huitinga, Chris H. Polman, Bernard M.J. Uitdehaag. (2007) CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis. Journal of Neuroimmunology 190:1-2, 157-164
CrossRef422
Jeffrey M. Rogers, Peter K. Panegyres. (2007) Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations. Journal of Clinical Neuroscience 14:10, 919-927
CrossRef423
C.D. Dos Santos, C.W. Picanço-Diniz, W. Gomes-Leal. (2007) Differential patterns of inflammatory response, axonal damage and myelin impairment following excitotoxic or ischemic damage to the trigeminal spinal nucleus of adult rats. Brain Research 1172, 130-144
CrossRef424
P.G. Bannerman, A. Hahn. (2007) Enhanced visualization of axonopathy in EAE using thy1-YFP transgenic mice. Journal of the Neurological Sciences 260:1-2, 23-32
CrossRef425
Adrienne R Boissy, Jeffrey A Cohen. (2007) Multiple sclerosis symptom management. Expert Review of Neurotherapeutics 7:9, 1213-1222
CrossRef426
Massimiliano Calabrese, Matteo Atzori, Valentina Bernardi, Aldo Morra, Chiara Romualdi, Luciano Rinaldi, Matthew J. M. McAuliffe, Luigi Barachino, Paola Perini, Bruce Fischl, Leontino Battistin, Paolo Gallo. (2007) Cortical atrophy is relevant in multiple sclerosis at clinical onset. Journal of Neurology 254:9, 1212-1220
CrossRef427
S. I. Moro, M. L. Rodriguez-Carmona, E. C. Frost, G. T. Plant, J. L. Barbur. (2007) Recovery of vision and pupil responses in optic neuritis and multiple sclerosis. Ophthalmic and Physiological Optics 27:5, 451-460
CrossRef428
Massimo Filippi, Hans-Peter Hartung. (2007) What do we really see when we look at magnetic resonance images?. Annals of Neurology 62:3, 207-209
CrossRef429
Yufen Qin, Raymond A Sobel. (2007) Mechanisms of injury in multiple sclerosis: involvement of antineuroaxonal humoral autoimmunity. Expert Review of Clinical Immunology 3:5, 653-657
CrossRef430
Dimitrios Karussis, Ibrahim Kassis. (2007) Use of stem cells for the treatment of multiple sclerosis. Expert Review of Neurotherapeutics 7:9, 1189-1201
CrossRef431
Elizabeth Fisher, Ansi Chang, Robert J. Fox, Jean A. Tkach, Therese Svarovsky, Kunio Nakamura, Richard A. Rudick, Bruce D. Trapp. (2007) Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Annals of Neurology 62:3, 219-228
CrossRef432
Bert A ’t Hart, S Anwar Jagessar, Yolanda S Kap, Herbert PM Brok. (2007) Preclinical models of multiple sclerosis in nonhuman primates. Expert Review of Clinical Immunology 3:5, 749-761
CrossRef433
Joel A. Black, Jia Newcombe, Bruce D. Trapp, Stephen G. Waxman. (2007) Sodium Channel Expression Within Chronic Multiple Sclerosis Plaques. Journal of Neuropathology and Experimental Neurology 66:9, 828-837
CrossRef434
The International Multiple Sclerosis Genetics Consortium. (2007) Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study. New England Journal of Medicine 357:9, 851-862
Full Text435
A CHARIL, M FILIPPI. (2007) Inflammatory demyelination and neurodegeneration in early multiple sclerosis. Journal of the Neurological Sciences 259:1-2, 7-15
CrossRef436
J PALACE. (2007) Inflammation versus neurodegeneration: Consequences for treatment
CrossRef437
Bianca Weinstock-Guttman, Robert Zivadinov, Miriam Tamaño-Blanco, Nadir Abdelrahman, Darlene Badgett, Jackie Durfee, Sara Hussein, Joan Feichter, Kara Patrick, Ralph Benedict, Murali Ramanathan. (2007) Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis. Journal of Neuroimmunology 188:1-2, 167-174
CrossRef438
Oscar Fernández. (2007) Combination therapy in multiple sclerosis. Journal of the Neurological Sciences 259:1-2, 95-103
CrossRef439
Bernadette Kalman, Karen Laitinen, Samuel Komoly. (2007) The involvement of mitochondria in the pathogenesis of multiple sclerosis. Journal of Neuroimmunology 188:1-2, 1-12
CrossRef440
Celia M Kassmann, Corinna Lappe-Siefke, Myriam Baes, Britta Brügger, Alexander Mildner, Hauke B Werner, Oliver Natt, Thomas Michaelis, Marco Prinz, Jens Frahm, Klaus-Armin Nave. (2007) Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nature Genetics 39:8, 969-976
CrossRef441
K. Kallenbach, J. Frederiksen. (2007) Optical coherence tomography in optic neuritis and multiple sclerosis: a review. European Journal of Neurology 14:8, 841-849
CrossRef442
Jeffrey I. Greenstein. (2007) Current concepts of the cellular and molecular pathophysiology of multiple sclerosis. Developmental Neurobiology 67:9, 1248-1265
CrossRef443
Ludwig Kappos, Mark S Freedman, Chris H Polman, Gilles Edan, Hans-Peter Hartung, David H Miller, Xavier Montalbán, Frederik Barkhof, Ernst-Wilhelm Radü, Lars Bauer, Susanne Dahms, Vivian Lanius, Christoph Pohl, Rupert Sandbrink. (2007) Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study. The Lancet 370:9585, 389-397
CrossRef444
Francesca Bagnato, Iordanis E Evangelou, Antonio Gallo, Deeya Gaindh, Karen Yao. (2007) The effect of interferon-β on black holes in patients with multiple sclerosis. Expert Opinion on Biological Therapy 7:7, 1079-1091
CrossRef445
Ranbir S. Mann, Cris S. Constantinescu, Christopher R. Tench. (2007) Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: Application of a new technique for measuring cross-sectional area on magnetic resonance images. Journal of Magnetic Resonance Imaging 26:1, 61-65
CrossRef446
Peter K. Stys. (2007) Sodium channel blockers as neuroprotectants in neuroinflammatory disease: a double-edged sword. Annals of Neurology 62:1, 3-5
CrossRef447
Cornelia Laule, Irene M. Vavasour, Shannon H. Kolind, David K. B. Li, Tony L. Traboulsee, G. R. Wayne Moore, Alex L. MacKay. (2007) Magnetic resonance imaging of myelin. Neurotherapeutics 4:3, 460-484
CrossRef448
Francisco J. Esteban, Jorge Sepulcre, Nieves Vélez de Mendizábal, Joaquín Goñi, Juan Navas, Juan Ruiz de Miras, Bartolome Bejarano, Jose C. Masdeu, Pablo Villoslada. (2007) Fractal dimension and white matter changes in multiple sclerosis. NeuroImage 36:3, 543-549
CrossRef449
J. Río, M. Tintoré, C. Nos, N. Téllez, I. Galán, R. Pelayo, X. Montalban. (2007) Interferon beta in secondary progressive multiple sclerosis. Journal of Neurology 254:7, 849-853
CrossRef450
Klaus Schmierer, Daniel J. Tozer, Francesco Scaravilli, Daniel R. Altmann, Gareth J. Barker, Paul S. Tofts, David H. Miller. (2007) Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain. Journal of Magnetic Resonance Imaging 26:1, 41-51
CrossRef451
W.A. Lagrèze. (2007) Steroide bei Sehnerverkrankungen?. Der Ophthalmologe 104:6, 517-520
CrossRef452
Charlotte E Teunissen, Joep Killestein, Gavin Giovannoni. (2007) Biomarker research in multiple sclerosis: addressing axonal damage and heterogeneity. Biomarkers in Medicine 1:1, 111-119
CrossRef453
Fiona Costello, Olaf Stüve, Martin S Weber, Scott S Zamvil, Elliot Frohman. (2007) Combination therapies for multiple sclerosis: scientific rationale, clinical trials, and clinical practice. Current Opinion in Neurology 20:3, 281-285
CrossRef454
C.E. Teunissen, S. Floris, M. Sonke, C.D. Dijkstra, H.E. De Vries, D. Lütjohann. (2007) 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 85:7, 1499-1505
CrossRef455
David A. Brown, Paul E. Sawchenko. (2007) Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis. The Journal of Comparative Neurology 502:2, 236-260
CrossRef456
Hans Lassmann. (2007) New concepts on progressive multiple sclerosis. Current Neurology and Neuroscience Reports 7:3, 239-244
CrossRef457
Bas Jasperse, Cornelis Jakobs, M. Judith Eikelenboom, Christine D. Dijkstra, Bernard M. J. Uitdehaag, Frederik Barkhof, Chris H. Polman, Charlotte E. Teunissen. (2007) N-acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometry. Journal of Neurology 254:5, 631-637
CrossRef458
Adam C. Vana, Claudia F. Lucchinetti, Tuan Q. Le, Regina C. Armstrong. (2007) Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. Glia 55:7, 687-697
CrossRef459
BRETT A. PARMENTER, JANET L. SHUCARD, DAVID W. SHUCARD. (2007) Information processing deficits in multiple sclerosis: A matter of complexity. Journal of the International Neuropsychological Society 13:03,
CrossRef460
Adrienne Boissy, Robert J. Fox. (2007) Current treatment options in multiple sclerosis. Current Treatment Options in Neurology 9:3, 176-186
CrossRef461
Marcelo Kremenchutzky, Sarah Morrow, Carolina Rush. (2007) The safety and efficacy of IFN-β products for the treatment of multiple sclerosis. Expert Opinion on Drug Safety 6:3, 279-288
CrossRef462
Birgit Ey, Igor Kobsar, Heinrich Blazyca, Antje Kroner, Rudolf Martini. (2007) Visualization of degenerating axons in a dysmyelinating mouse mutant with axonal loss. Molecular and Cellular Neuroscience 35:1, 153-160
CrossRef463
Tanuja Chitnis, Jaime Imitola, Yue Wang, Wassim Elyaman, Prianka Chawla, Maia Sharuk, Khadir Raddassi, Roderick T. Bronson, Samia J. Khoury. (2007) Elevated Neuronal Expression of CD200 Protects Wlds Mice from Inflammation-Mediated Neurodegeneration. The American Journal of Pathology 170:5, 1695-1712
CrossRef464
M MOTAMED, N NAJIMI, S FERESHTEHNEJAD. (2007) The effect of interferon-beta1a on relapses and progression of disability in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis. Clinical Neurology and Neurosurgery 109:4, 344-349
CrossRef465
Fred D. Lublin. (2007) The incomplete nature of multiple sclerosis relapse resolution. Journal of the Neurological Sciences 256, S14-S18
CrossRef466
Molly E. Gilbert, Robert C. Sergott. (2007) New directions in optic neuritis and multiple sclerosis. Current Neurology and Neuroscience Reports 7:3, 259-264
CrossRef467
S. Cader, H. Johansen-Berg, M. Wylezinska, J. Palace, T.E. Behrens, S. Smith, P.M. Matthews. (2007) Discordant white matter N-acetylasparate and diffusion MRI measures suggest that chronic metabolic dysfunction contributes to axonal pathology in multiple sclerosis. NeuroImage 36:1, 19-27
CrossRef468
M. Forte, B. G. Gold, G. Marracci, P. Chaudhary, E. Basso, D. Johnsen, X. Yu, J. Fowlkes, M. Rahder, K. Stem, P. Bernardi, D. Bourdette. (2007) Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proceedings of the National Academy of Sciences 104:18, 7558-7563
CrossRef469
Hans Lassmann, Wolfgang Brück, Claudia F. Lucchinetti. (2007) The Immunopathology of Multiple Sclerosis: An Overview. Brain Pathology 17:2, 210-218
CrossRef470
Nicola De Stefano, Massimo Filippi. (2007) MR Spectroscopy in Multiple Sclerosis. Journal of Neuroimaging 17, 31S-35S
CrossRef471
Jack van Horssen, Bianca P. Brink, Helga E. de Vries, Paul van der Valk, Lars Bø. (2007) The Blood-Brain Barrier in Cortical Multiple Sclerosis Lesions. Journal of Neuropathology and Experimental Neurology 66:4, 321-328
CrossRef472
Kenneth J. Smith. (2007) Sodium Channels and Multiple Sclerosis: Roles in Symptom Production, Damage and Therapy. Brain Pathology 17:2, 230-242
CrossRef473
Ruth Huizinga, Nicole Heijmans, Pia Schubert, Steve Gschmeissner, Bert A. 't Hart, Harald Herrmann, Sandra Amor. (2007) Immunization With Neurofilament Light Protein Induces Spastic Paresis and Axonal Degeneration in Biozzi ABH Mice. Journal of Neuropathology and Experimental Neurology 66:4, 295-304
CrossRef474
Richard A. Rudick, Gary Cutter. (2007) Interferon-β for multiple sclerosis: Long-term benefits?. Annals of Neurology 61:4, 283-285
CrossRef475
Klaus Schmierer, Claudia A.M. Wheeler-Kingshott, Phil A. Boulby, Francesco Scaravilli, Daniel R. Altmann, Gareth J. Barker, Paul S. Tofts, David H. Miller. (2007) Diffusion tensor imaging of post mortem multiple sclerosis brain. NeuroImage 35:2, 467-477
CrossRef476
Fabian Docagne, Vilma Muñetón, Diego Clemente, Carine Ali, Frida Loría, Fernando Correa, Míriam Hernangómez, Leyre Mestre, Denis Vivien, Carmen Guaza. (2007) Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation. Molecular and Cellular Neuroscience 34:4, 551-561
CrossRef477
Hugo Vrenken, Jeroen JG Geurts. (2007) Gray and normal-appearing white matter in multiple sclerosis: an MRI perspective. Expert Review of Neurotherapeutics 7:3, 271-279
CrossRef478
H. Onoue, J.-I. Satoh, M. Ogawa, H. Tabunoki, T. Yamamura. (2007) Detection of anti-Nogo receptor autoantibody in the serum of multiple sclerosis and controls. Acta Neurologica Scandinavica 115:3, 153-160
CrossRef479
Katharina Maier, Doron Merkler, Joachim Gerber, Naimeh Taheri, Antje V. Kuhnert, Sarah K. Williams, Clemens Neusch, Mathias Bähr, Ricarda Diem. (2007) Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation. Neurobiology of Disease 25:3, 514-525
CrossRef480
Sean J. Pittock, Claudia F. Lucchinetti. (2007) The Pathology of MS. The Neurologist 13:2, 45-56
CrossRef481
George Harauz, Abdiwahab A. Musse. (2007) A Tale of Two Citrullines—Structural and Functional Aspects of Myelin Basic Protein Deimination in Health and Disease. Neurochemical Research 32:2, 137-158
CrossRef482
Joana Câmara, Charles ffrench-Constant. (2007) Lessons from oligodendrocyte biology on promoting repair in multiple sclerosis. Journal of Neurology 254:S1, I15-I22
CrossRef483
Cindy X. Zhang-Gandhi, Paul D. Drew. (2007) Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes. Journal of Neuroimmunology 183:1-2, 50-59
CrossRef484
Massimo Filippi, Maria A. Rocca. (2007) Magnetic resonance imaging techniques to define and monitor tissue damage and repair in multiple sclerosis. Journal of Neurology 254:S1, I55-I62
CrossRef485
J. Satoh, H. Tabunoki, T. Yamamura, K. Arima, H. Konno. (2007) TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Neuropathology and Applied Neurobiology 33:1,
CrossRef486
Wolfgang Brück. (2007) New insights into the pathology of multiple sclerosis: towards a unified concept?. Journal of Neurology 254:S1, I3-I9
CrossRef487
Philip L. De Jager, David A. Hafler. (2007) New Therapeutic Approaches for Multiple Sclerosis. Annual Review of Medicine 58:1, 417-432
CrossRef488
Andrea Gagliardo, Francesca Galli, Antonello Grippo, Aldo Amantini, Cristiana Martinelli, Maria Pia Amato, Walter Borsini. (2007) Motor evoked potentials in multiple sclerosis patients without walking limitation: amplitude vs. conduction time abnormalities. Journal of Neurology 254:2, 220-227
CrossRef489
Claudia J Calder, Martin Duddy, Amit Bar-Or. (2007) B-cell subsets: cellular interactions and relevance in multiple sclerosis. Expert Review of Clinical Immunology 3:1, 73-83
CrossRef490
Mohamed El Behi, Hélène Zéphir, Didier Lefranc, Virginie Dutoit, Patricia Dussart, Patrick Devos, Jean Paul Dessaint, Patrick Vermersch, Lionel Prin. (2007) Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. Journal of Neuroimmunology 182:1-2, 80-88
CrossRef491
Ikuo Tsunoda, Tomoko Tanaka, Emily Jane Terry, Robert S. Fujinami. (2007) Contrasting Roles for Axonal Degeneration in an Autoimmune versus Viral Model of Multiple Sclerosis. The American Journal of Pathology 170:1, 214-226
CrossRef492
Valerie M. Anderson, Kryshani T.M. Fernando, Gerard R. Davies, Waqar Rashid, Chris Frost, Nick C. Fox, David H. Miller. (2007) Cerebral Atrophy Measurement in Clinically Isolated Syndromes and Relapsing Remitting Multiple Sclerosis: A Comparison of Registration-Based Methods. Journal of Neuroimaging 17:1, 61-68
CrossRef493
Jonathan L. McQualter, Claude C. A. Bernard. (2007) Multiple sclerosis: a battle between destruction and repair. Journal of Neurochemistry 100:2, 295-306
CrossRef494
M. Thangarajh, T. Masterman, J. Hillert, S. Moerk, R. Jonsson. (2007) A Proliferation-inducing Ligand (APRIL) is Expressed by Astrocytes and is Increased in Multiple Sclerosis. Scandinavian Journal of Immunology 65:1, 92-98
CrossRef495
Aleš Bartoš, Lenka Fialová, Jiřina Soukupová, Jaromír Kukal, Ivan Malbohan, Jiří Piťha. (2007) Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis. Journal of Neurology 254:1, 20-25
CrossRef496
Asgar Zaheer, Smita Zaheer, Shailendra K. Sahu, Baoli Yang, Ramon Lim. (2006) Reduced Severity of Experimental Autoimmune Encephalomyelitis in GMF-Deficient Mice. Neurochemical Research 32:1, 39-47
CrossRef497
J. van Horssen, C. M. P. Vos, L. Admiraal, E. S. van Haastert, L. Montagne, P. van der Valk, H. E. de Vries. (2006) Matrix metalloproteinase-19 is highly expressed in active multiple sclerosis lesions. Neuropathology and Applied Neurobiology 32:6, 585-593
CrossRef498
David A. Bechtold, Sandra J. Miller, Angela C. Dawson, Yue Sun, Raju Kapoor, David Berry, Kenneth J. Smith. (2006) Axonal protection achieved in a model of multiple sclerosis using lamotrigine. Journal of Neurology 253:12, 1542-1551
CrossRef499
Sumita Adhya, Glyn Johnson, Joseph Herbert, Hina Jaggi, James S. Babb, Robert I. Grossman, Matilde Inglese. (2006) Pattern of hemodynamic impairment in multiple sclerosis: Dynamic susceptibility contrast perfusion MR imaging at 3.0 T. NeuroImage 33:4, 1029-1035
CrossRef500
Jai Perumal, Massimo Filippi, Corey Ford, Kenneth Johnson, Robert Lisak, Luanne Metz, Alexandros Tselis, Mark Tullman, Omar Khan. (2006) Glatiramer acetate therapy for multiple sclerosis: a review. Expert Opinion on Drug Metabolism & Toxicology 2:6, 1019-1029
CrossRef501
Jennifer L. Gardell, Paul Dazin, Janeen Islar, Til Menge, Claude P. Genain, Patrice H. Lalive. (2006) Apoptotic effects of Human Herpesvirus-6A on glia and neurons as potential triggers for central nervous system autoimmunity. Journal of Clinical Virology 37, S11-S16
CrossRef502
Stephen G. Waxman. (2006) Axonal conduction and injury in multiple sclerosis: the role of sodium channels. Nature Reviews Neuroscience 7:12, 932-941
CrossRef503
Cinzia Dello Russo, Paul E. Polak, Pilar R. Mercado, Alessandra Spagnolo, Anthony Sharp, Patricia Murphy, Adeela Kamal, Francis J. Burrows, Lawrence C. Fritz, Douglas L. Feinstein. (2006) The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. Journal of Neurochemistry 99:5, 1351-1362
CrossRef504
Katica Jovanova-Nesic, Yehuda Shoenfeld. (2006) MMP-2, VCAM-1 and NCAM-1 expression in the brain of rats with experimental autoimmune encephalomyelitis as a trigger mechanism for synaptic plasticity and pathology. Journal of Neuroimmunology 181:1-2, 112-121
CrossRef505
Bernd C. Kieseier. (2006) Assessing long-term effects of disease-modifying drugs. Journal of Neurology 253:S6, vi23-vi30
CrossRef506
Jack H. Simon, Song Zhang, David H. Laidlaw, David E. Miller, Mark Brown, John Corboy, Jeffrey Bennett. (2006) Identification of fibers at risk for degeneration by diffusion tractography in patients at high risk for MS after a clinically isolated syndrome. Journal of Magnetic Resonance Imaging 24:5, 983-988
CrossRef507
Manoj Kumar, Norman Putzki, Volker Limmroth, Ralph Remus, Monika Lindemann, Dietmar Knop, Norbert Mueller, Cornelia Hardt, Ernst Kreuzfelder, Hans Grosse-Wilde. (2006) CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis. Journal of Neuroimmunology 180:1-2, 178-184
CrossRef508
2006. Diabetic Nephropathy. .
CrossRef509
Susan A. Gauthier, Bonnie I. Glanz, Micha Mandel, Howard L. Weiner. (2006) A model for the comprehensive investigation of a chronic autoimmune disease: The multiple sclerosis CLIMB study. Autoimmunity Reviews 5:8, 532-536
CrossRef510
Mark S Freedman. (2006) Disease-modifying drugs for multiple sclerosis: current and future aspects. Expert Opinion on Pharmacotherapy 7:s1, S1-S9
CrossRef511
Elliot Frohman, Fiona Costello, Robert Zivadinov, Olaf Stuve, Amy Conger, Heather Winslow, Anand Trip, Teresa Frohman, Laura Balcer. (2006) Optical coherence tomography in multiple sclerosis. The Lancet Neurology 5:10, 853-863
CrossRef512
Katharina Maier, Antje V. Kuhnert, Naimeh Taheri, Muriel B. Sättler, Maria K. Storch, Sarah K. Williams, Mathias Bähr, Ricarda Diem. (2006) Effects of Glatiramer Acetate and Interferon-β on Neurodegeneration in a Model of Multiple Sclerosis. The American Journal of Pathology 169:4, 1353-1364
CrossRef513
Kappos, Ludwig, Antel, Jack, Comi, Giancarlo, Montalban, Xavier, O'Connor, Paul, Polman, Chris H., Haas, Tomas, Korn, Alexander A., Karlsson, Goeril, Radue, Ernst W., . (2006) Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis. New England Journal of Medicine 355:11, 1124-1140
Full Text514
Chunhe Wang, Bruce G. Gold, Laurie J. Kaler, Xiaolin Yu, Michael E. Afentoulis, Gregory G. Burrows, Arthur A. Vandenbark, Dennis N. Bourdette, Halina Offner. (2006) Antigen-Specific Therapy Promotes Repair of Myelin and Axonal Damage in Established EAE. Journal of Neurochemistry 98:6, 1817-1827
CrossRef515
Ales Dudesek, Uwe K. Zettl. (2006) Intravenous immunoglobulins as therapeutic option in the treatment of multiple sclerosis. Journal of Neurology 253:S5, v50-v58
CrossRef516
Mark J. Lowe, Craig Horenstein, Jochen G. Hirsch, Ruth Ann Marrie, Lael Stone, Pallab K. Bhattacharyya, Achim Gass, Micheal D. Phillips. (2006) Functional pathway-defined MRI diffusion measures reveal increased transverse diffusivity of water in multiple sclerosis. NeuroImage 32:3, 1127-1133
CrossRef517
Yangtai Guan, Kenneth S. Shindler, Philomela Tabuena, A.M. Rostami. (2006) Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. Journal of Neuroimmunology 178:1-2, 40-48
CrossRef518
Muriel B. Sättler, Iris Demmer, Sarah K. Williams, Katharina Maier, Doron Merkler, Ivana Gadjanski, Christine Stadelmann, Mathias Bähr, Ricarda Diem. (2006) Effects of interferon-beta-1a on neuronal survival under autoimmune inflammatory conditions. Experimental Neurology 201:1, 172-181
CrossRef519
BRETT A. PARMENTER, JANET L. SHUCARD, RALPH H.B. BENEDICT, DAVID W. SHUCARD. (2006) Working memory deficits in multiple sclerosis: Comparison between the n-back task and the Paced Auditory Serial Addition Test. Journal of the International Neuropsychological Society 12:05,
CrossRef520
Frauke Zipp, Orhan Aktas. (2006) The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends in Neurosciences 29:9, 518-527
CrossRef521
Leah P. Shriver, Bonnie N. Dittel. (2006) T-Cell-Mediated Disruption of the Neuronal Microtubule Network. The American Journal of Pathology 169:3, 999-1011
CrossRef522
Shu-Wei Sun, Hsiao-Fang Liang, Tuan Q. Le, Regina C. Armstrong, Anne H. Cross, Sheng-Kwei Song. (2006) Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia. NeuroImage 32:3, 1195-1204
CrossRef523
Jing Zhang, Yi Li, Mei Lu, Yisheng Cui, Jieli Chen, Lori Noffsinger, Stanton B. Elias, Michael Chopp. (2006) Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice. Journal of Neuroscience Research 84:3, 587-595
CrossRef524
Jack Rosenbluth, Klaus-Armin Nave, Amanda Mierzwa, Rolf Schiff. (2006) Subtle myelin defects in PLP-null mice. Glia 54:3, 172-182
CrossRef525
Tina M. Calderon, Eliseo A. Eugenin, Lillie Lopez, Sridhar Sampath Kumar, Joseph Hesselgesser, Cedric S. Raine, Joan W. Berman. (2006) A role for CXCL12 (SDF-1α) in the pathogenesis of multiple sclerosis: Regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. Journal of Neuroimmunology 177:1-2, 27-39
CrossRef526
B. Brochet, M.S.A. Deloire, T. Touil, O. Anne, J.M. Caillé, V. Dousset, K.G. Petry. (2006) Early macrophage MRI of inflammatory lesions predicts lesion severity and disease development in relapsing EAE. NeuroImage 32:1, 266-274
CrossRef527
Yulin Ge. (2006) Seeing Is Believing. Topics in Magnetic Resonance Imaging 17:4, 295-306
CrossRef528
Doreen Schulz, Bruno Kopp, Annett Kunkel, Jürgen H. Faiss. (2006) Cognition in the early stage of multiple sclerosis. Journal of Neurology 253:8, 1002-1010
CrossRef529
Helle H. Nielsen, Rune Ladeby, Nina Drøjdahl, Alan C. Peterson, Bente Finsen. (2006) Axonal degeneration stimulates the formation of NG2+ cells and oligodendrocytes in the mouse. Glia 54:2, 105-115
CrossRef530
Naoyuki Tanuma, Hiroshi Sakuma, Atsushi Sasaki, Yoh Matsumoto. (2006) Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis. Acta Neuropathologica 112:2, 195-204
CrossRef531
Angela D. Janke, Fabrizio Giuliani, V. Wee Yong. (2006) IVIg attenuates T cell-mediated killing of human neurons. Journal of Neuroimmunology 177:1-2, 181-188
CrossRef532
Heather C. Wilson, Neil J. Scolding, Cedric S. Raine. (2006) Co-expression of PDGF α receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. Journal of Neuroimmunology 176:1-2, 162-173
CrossRef533
Jihong Xu, Janet A. Chavis, Michael K. Racke, Paul D. Drew. (2006) Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes. Journal of Neuroimmunology 176:1-2, 95-105
CrossRef534
A STUIFBERGEN, S BLOZIS, T HARRISON, H BECKER. (2006) Exercise, Functional Limitations, and Quality of Life: A Longitudinal Study of Persons With Multiple Sclerosis. Archives of Physical Medicine and Rehabilitation 87:7, 935-943
CrossRef535
M. Pugliatti, G. Rosati, H. Carton, T. Riise, J. Drulovic, L. Vecsei, I. Milanov. (2006) The epidemiology of multiple sclerosis in Europe. European Journal of Neurology 13:7, 700-722
CrossRef536
Richard A. Rudick. (2006) Disease modification in multiple sclerosis: Issues with relevance to clinical trial designs in Alzheimer’s disease. Alzheimer's and Dementia 2:3, 143-146
CrossRef537
X MONTALBAN, J RIO. (2006) Interferons and cognition. Journal of the Neurological Sciences 245:1-2, 137-140
CrossRef538
P FONTOURA, L STEINMAN. (2006) Nogo in multiple sclerosis: Growing roles of a growth inhibitor. Journal of the Neurological Sciences 245:1-2, 201-210
CrossRef539
C CHRISTODOULOU, P MELVILLE, W SCHERL, W MACALLISTER, L ELKINS, L KRUPP. (2006) Effects of donepezil on memory and cognition in multiple sclerosis
CrossRef540
Gail H. Marracci, Whitney E. Marquardt, Adrienne Strehlow, Gabriel P. McKeon, Jonathan Gross, David C. Buck, Laura B. Kozell, Dennis N. Bourdette. (2006) Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56Lck. Biochemical and Biophysical Research Communications 344:3, 963-971
CrossRef541
Nathalie Jette, Elaine Coderre, Maria A Nikolaeva, Paula D Enright, Akira Iwata, Douglas H Smith, Qiubo Jiang, Peter K Stys. (2006) Spatiotemporal distribution of spectrin breakdown products induced by anoxia in adult rat optic nerve in vitro. Journal of Cerebral Blood Flow & Metabolism 26:6, 777-786
CrossRef542
C. E. Teunissen, C. D. Dijkstra, B. Jasperse, F. Barkhof, H. Vanderstichele, E. Vanmechelen, C. H. Polman, L. Bo. (2006) Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis. Neuropathology and Applied Neurobiology 32:3, 318-331
CrossRef543
Helen Andrews, Kathryn White, Christine Thomson, Julia Edgar, David Bates, Ian Griffiths, Douglass Turnbull, Philip Nichols. (2006) Increased axonal mitochondrial activity as an adaptation to myelin deficiency in theShiverer mouse. Journal of Neuroscience Research 83:8, 1533-1539
CrossRef544
K-A. Irvine, W.F. Blakemore. (2006) Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice. Journal of Neuroimmunology 175:1-2, 69-76
CrossRef545
Fiona Costello, Stuart Coupland, William Hodge, Gianni R. Lorello, Jeannie Koroluk, Y. Irene Pan, Mark S. Freedman, David H. Zackon, Randy H. Kardon. (2006) Quantifying axonal loss after optic neuritis with optical coherence tomography. Annals of Neurology 59:6, 963-969
CrossRef546
C. Malmeström, B.A. Andersson, S. Haghighi, J. Lycke. (2006) IL-6 and CCL2 levels in CSF are associated with the clinical course of MS: Implications for their possible immunopathogenic roles. Journal of Neuroimmunology 175:1-2, 176-182
CrossRef547
L BONFIGLIO, B ROSSI, F SARTUCCI. (2006) Prolonged intracortical delay of long-latency reflexes: Electrophysiological evidence for a cortical dysfunction in multiple sclerosis. Brain Research Bulletin 69:6, 606-613
CrossRef548
Bernadette Kalman. (2006) Role of mitochondria in multiple sclerosis. Current Neurology and Neuroscience Reports 6:3, 244-252
CrossRef549
A. Compston. (2006) The basis for treatment in multiple sclerosis. Acta Neurologica Scandinavica 113:s183, 41-47
CrossRef550
Noel G. Carlson, Kenneth E. Hill, Ikuo Tsunoda, Robert S. Fujinami, John W. Rose. (2006) The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. Journal of Neuroimmunology 174:1-2, 21-31
CrossRef551
Valerie M. Anderson, Nick C. Fox, David H. Miller. (2006) Magnetic resonance imaging measures of brain atrophy in multiple sclerosis. Journal of Magnetic Resonance Imaging 23:5, 605-618
CrossRef552
K.-M. Myhr, N. Grytten, J. H. Aarseth, H. Nyland. (2006) The Norwegian Multiple Sclerosis National Competence Centre and National Multiple Sclerosis registry - a resource for clinical practice and research. Acta Neurologica Scandinavica 113:s183, 37-40
CrossRef553
S. Anand Trip, Patricio G. Schlottmann, Stephen J. Jones, Wai-Yung Li, David F. Garway-Heath, Alan J. Thompson, Gordon T. Plant, David H. Miller. (2006) Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: Evidence that axonal loss is a substrate of MRI-detected atrophy. NeuroImage 31:1, 286-293
CrossRef554
Dimitrios Papadopoulos, Lisa Ewans, Danielle Pham-Dinh, Johanna Knott, Richard Reynolds. (2006) Upregulation of α-synuclein in neurons and glia in inflammatory demyelinating disease. Molecular and Cellular Neuroscience 31:4, 597-612
CrossRef555
Alireza Minagar, Wenche Jy, J. J. Jimenez, J. Steven Alexander. (2006) Multiple sclerosis as a vascular disease. Neurological Research 28:3, 230-235
CrossRef556
Gregory P. Owens, Jeffrey L. Bennett, Donald H. Gilden, Mark P. Burgoon. (2006) The B cell response in multiple sclerosis. Neurological Research 28:3, 236-244
CrossRef557
Ofira Einstein, Nikolaos Grigoriadis, Rachel Mizrachi-Kol, Etti Reinhartz, Eleni Polyzoidou, Iris Lavon, Ioannis Milonas, Dimitrios Karussis, Oded Abramsky, Tamir Ben-Hur. (2006) Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis. Experimental Neurology 198:2, 275-284
CrossRef558
Jeremiah McDole, Aaron J. Johnson, Istvan Pirko. (2006) The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis. Neurological Research 28:3, 256-261
CrossRef559
Maria Diaz-Sanchez, Kelly Williams, Gabriele C. DeLuca, Margaret M. Esiri. (2006) Protein co-expression with axonal injury in multiple sclerosis plaques. Acta Neuropathologica 111:4, 289-299
CrossRef560
Bernhard Hemmer, Stefan Nessler, Dun Zhou, Bernd Kieseier, Hans-Peter Hartung. (2006) Immunopathogenesis and immunotherapy of multiple sclerosis. Nature Clinical Practice Neurology 2:4, 201-211
CrossRef561
Peter M. Smith, Nick D. Jeffery. (2006) Histological and Ultrastructural Analysis of White Matter Damage after Naturally-occurring Spinal Cord Injury. Brain Pathology 16:2, 99-109
CrossRef562
Sylvia Delgado, William A. Sheremata. (2006) The role of CD4+ T-cells in the development of MS. Neurological Research 28:3, 245-249
CrossRef563
S. Anand Trip, Claudia Wheeler-Kingshott, Stephen J. Jones, Wai-Yung Li, Gareth J. Barker, Alan J. Thompson, Gordon T. Plant, David H. Miller. (2006) Optic nerve diffusion tensor imaging in optic neuritis. NeuroImage 30:2, 498-505
CrossRef564
Katrin Morgen, Gebhard Sammer, Susan M. Courtney, Tobias Wolters, Hanne Melchior, Carlo R. Blecker, Patrick Oschmann, Manfred Kaps, Dieter Vaitl. (2006) Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing–remitting MS. NeuroImage 30:3, 891-898
CrossRef565
Elena Gonzalez-Rey, Amelia Fernandez-Martin, Alejo Chorny, Javier Martin, David Pozo, Doina Ganea, Mario Delgado. (2006) Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Autoimmune Encephalomyelitis. The American Journal of Pathology 168:4, 1179-1188
CrossRef566
Doron Merkler, Robert Boscke, Barthel Schmelting, Boldizsar Czeh, Eberhard Fuchs, Wolfgang Bruck, Christine Stadelmann. (2006) Differential Macrophage/Microglia Activation in Neocortical EAE Lesions in the Marmoset Monkey. Brain Pathology 16:2, 117-123
CrossRef567
Samuel K. Ludwin. (2006) The Pathogenesis of Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology 65:4, 305-318
CrossRef568
Frohman, Elliot M., Racke, Michael K., Raine, Cedric S., . (2006) Multiple Sclerosis — The Plaque and Its Pathogenesis. New England Journal of Medicine 354:9, 942-955
Full Text569
G REBOLLEDA, F MUNOZNEGRETE, S NOVAL, I CONTRERAS, M GILBERT, R SERGOTT. (2006) New Ways To Look at an Old Problem. Survey of Ophthalmology 51:2, 169-173
CrossRef570
Ranjan Dutta, Jennifer McDonough, Xinghua Yin, John Peterson, Ansi Chang, Thalia Torres, Tatyana Gudz, Wendy B. Macklin, David A. Lewis, Robert J. Fox, Richard Rudick, Karoly Mirnics, Bruce D. Trapp. (2006) Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Annals of Neurology 59:3, 478-489
CrossRef571
Divya M. Chari, Chao Zhao, Mark R. Kotter, William F. Blakemore, Robin J.M. Franklin. (2006) Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system. Journal of Neuroscience Research 83:4, 594-605
CrossRef572
Dimitrios Papadopoulos, Danielle Pham-Dinh, Richard Reynolds. (2006) Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat. Experimental Neurology 197:2, 373-385
CrossRef573
Robert A Bermel, Rohit Bakshi. (2006) The measurement and clinical relevance of brain atrophy in multiple sclerosis. The Lancet Neurology 5:2, 158-170
CrossRef574
Jihong Xu, Paul D. Drew. (2006) 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes. Journal of Neuroimmunology 171:1-2, 135-144
CrossRef575
Eva Eljaschewitsch, Anke Witting, Christian Mawrin, Thomas Lee, Peter M. Schmidt, Susanne Wolf, Heide Hoertnagl, Cedric S. Raine, Regine Schneider-Stock, Robert Nitsch, Oliver Ullrich. (2006) The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells. Neuron 49:1, 67-79
CrossRef576
Noel G Carlson, John W Rose. (2006) Antioxidants in Multiple Sclerosis. CNS Drugs 20:6, 433-441
CrossRef577
David C. Mohr, Daniel Pelletier. (2006) A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis. Brain, Behavior, and Immunity 20:1, 27-36
CrossRef578
Seyda Ugurlu, Nazife Sefi Yurdakul, Cemil Demir, Ahmet Maden. (2006) Evaluation of the Optic Nerve Head Using Confocal Scanning Laser Ophthalmoscopy in Patients with Multiple Sclerosis. Neuro-Ophthalmology 30:1, 23-28
CrossRef579
J SIMON. (2006) Update on Multiple Sclerosis. Radiologic Clinics of North America 44:1, 79-100
CrossRef580
Sridar Narayanan, Simon J. Francis, John G. Sled, A.C. Santos, Samson Antel, Ives Levesque, Steven Brass, Yves Lapierre, Dominique Sappey-Marinier, G. Bruce Pike, Douglas L. Arnold. (2006) Axonal injury in the cerebral normal-appearing white matter of patients with multiple sclerosis is related to concurrent demyelination in lesions but not to concurrent demyelination in normal-appearing white matter. NeuroImage 29:2, 637-642
CrossRef581
Ruth Ann Marrie, Richard A Rudick. (2006) Drug Insight: interferon treatment in multiple sclerosis. Nature Clinical Practice Neurology 2:1, 34-44
CrossRef582
Bert A. 't Hart, Paul Smith, Sandra Amor, Gustav J. Strijkers, Erwin L.A. Blezer. (2006) MRI-guided immunotherapy development for multiple sclerosis in a primate. Drug Discovery Today 11:1-2, 58-66
CrossRef583
David Pleasure, Athena Soulika, Sunit K. Singh, Vittorio Gallo, Peter Bannerman. (2006) Inflammation in white matter: Clinical and pathophysiological aspects. Mental Retardation and Developmental Disabilities Research Reviews 12:2, 141-146
CrossRef584
Alexandre I. Danilov, Ruxandra Covacu, Morten C. Moe, Iver A. Langmoen, Clas B. Johansson, Tomas Olsson, Lou Brundin. (2006) Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis. European Journal of Neuroscience 23:2, 394-400
CrossRef585
A. J. Coles, A. Cox, E. Page, J. Jones, S. A. Trip, J. Deans, S. Seaman, D. H. Miller, G. Hale, H. Waldmann, D. A. Compston. (2006) The window of therapeutic opportunity in multiple sclerosis. Journal of Neurology 253:1, 98-108
CrossRef586
C. Binquet, C. Quantin, G. Le Teuff, J.F. Pagliano, M. Abrahamowicz, T. Moreau. (2006) The Prognostic Value of Initial Relapses on the Evolution of Disability in Patients with Relapsing-Remitting Multiple Sclerosis. Neuroepidemiology 27:1, 45-54
CrossRef587
Fredrik Piehl. (2006) Inflammation and neurodegeneration. Future Neurology 1:1, 97-105
CrossRef588
D.A. Carone, R.H.B. Benedict, M.G. Dwyer, D.L. Cookfair, B. Srinivasaraghavan, C.W. Tjoa, R. Zivadinov. (2006) Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS. NeuroImage 29:2, 505-514
CrossRef589
J FAULKNER, H KEIRSTEAD. (2005) Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury. Transplant Immunology 15:2, 131-142
CrossRef590
Ralf Gold. (2005) Overcoming failure to repair demyelination in EAE: An important step towards neuroprotection in multiple sclerosis. Journal of Neuroimmunology 170:1-2, 1-2
CrossRef591
Catharina M.P. Vos, Jeroen J.G. Geurts, Lisette Montagne, Elise S. van Haastert, Lars Bö, Paul van der Valk, Frederik Barkhof, Helga E. de Vries. (2005) Blood–brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiology of Disease 20:3, 953-960
CrossRef592
Robert C Sergott. (2005) Optical coherence tomography: measuring in-vivo axonal survival and neuroprotection in multiple sclerosis and optic neuritis. Current Opinion in Ophthalmology 16:6, 346-350
CrossRef593
Jordi Río, Xavier Montalban. (2005) Interferon-β 1b in the treatment of multiple sclerosis. Expert Opinion on Pharmacotherapy 6:16, 2877-2886
CrossRef594
Khalad Karram, Nivedita Chatterjee, Jacqueline Trotter. (2005) NG2-expressing cells in the nervous system: role of the proteoglycan in migration and glial-neuron interaction. Journal of Anatomy 207:6, 735-744
CrossRef595
Rachel Farrell, Dominic Heaney, Gavin Giovannoni. (2005) Emerging therapies in multiple sclerosis. Expert Opinion on Emerging Drugs 10:4, 797-816
CrossRef596
Michael Coleman. (2005) Axon degeneration mechanisms: commonality amid diversity. Nature Reviews Neuroscience 6:11, 889-898
CrossRef597
Massimo Filippi, Maria Assunta Rocca. (2005) MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system. Journal of Neurology 252:S5, v16-v24
CrossRef598
Orhan Aktas. (2005) New aspects regarding mechanisms of tissue damage in the course of autoimmune demyelination. Signal Transduction 5:5, 245-249
CrossRef599
Ponnada A. Narayana. (2005) Magnetic Resonance Spectroscopy in the Monitoring of Multiple Sclerosis. Journal of Neuroimaging 15, 46S-57S
CrossRef600
Ricarda Diem, Muriel B. Sättler, Katharina Maier, Mathias Bähr. (2005) Molecular mechanisms of neuronal apoptosis in chronic inflammatory CNS diseases. Signal Transduction 5:5, 250-257
CrossRef601
Yiping Zhang, Reng-Rong Da, Lutz G. Hilgenberg, Wallace W. Tourtellotte, Raymond A. Sobel, Martin A. Smith, Michael Olek, Rashed Nagra, Gupta Sudhir, Stanley van den Noort, Yufen Qin. (2005) Clonal expansion of IgA-positive plasma cells and axon-reactive antibodies in MS lesions. Journal of Neuroimmunology 167:1-2, 120-130
CrossRef602
S. Lindquist, B.H. Schott, M. Ban, D.A.S. Compston, S. Sawcer, M. Sailer. (2005) The BDNF-Val66Met polymorphism: Implications for susceptibility to multiple sclerosis and severity of disease. Journal of Neuroimmunology 167:1-2, 183-185
CrossRef603
Hartmut Lins. (2005) Clinical Add-on: Multiple sclerosis – clinical picture and therapeutic strategies. Signal Transduction 5:5, 266-272
CrossRef604
Jan Dörr, Karl Roth, Urte Zurbuchen, Rudolf Deisz, Ingo Bechmann, Thomas-Nicolas Lehmann, Susanne Meier, Robert Nitsch, Frauke Zipp. (2005) Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate. Journal of Neuroimmunology 167:1-2, 204-209
CrossRef605
Rohit Bakshi, Venkata S. R. Dandamudi, Mohit Neema, Chitradeep De, Robert A. Bermel. (2005) Measurement of Brain and Spinal Cord Atrophy by Magnetic Resonance Imaging as a Tool to Monitor Multiple Sclerosis. Journal of Neuroimaging 15, 30S-45S
CrossRef606
Wolfgang Brück. (2005) Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis. Journal of Neurology 252:S5, v10-v15
CrossRef607
Douglas L. Arnold. (2005) Changes observed in multiple sclerosis using magnetic resonance imaging reflect a focal pathology distributed along axonal pathways. Journal of Neurology 252:S5, v25-v29
CrossRef608
Wolfgang Brück. (2005) The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. Journal of Neurology 252:S5, v3-v9
CrossRef609
Matilde Inglese, Robert I. Grossman, Massimo Filippi. (2005) Magnetic Resonance Imaging Monitoring of Multiple Sclerosis Lesion Evolution. Journal of Neuroimaging 15, 22S-29S
CrossRef610
Oscar A. Bizzozero, Gisela DeJesus, Kelly Callahan, Andrzej Pastuszyn. (2005) Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis. Journal of Neuroscience Research 81:5, 687-695
CrossRef611
S. Anand Trip, Patricio G. Schlottmann, Stephen J. Jones, Daniel R. Altmann, David F. Garway-Heath, Alan J. Thompson, Gordon T. Plant, David H. Miller. (2005) Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Annals of Neurology 58:3, 383-391
CrossRef612
Ludwig Kappos, Lutz Achtnichts, Frank Dahlke, Jens Kuhle, Y. Naegelin, Rupert Sandbrink, Raija L. P. Lindberg. (2005) Genomics and proteomics: role in the management of multiple sclerosis. Journal of Neurology 252:S3, iii21-iii27
CrossRef613
Miguel Angel Riudavets, Carlos Colegial, Ana Rubio, David Fowler, Carlos Pardo, Juan C. Troncoso. (2005) Causes of Unexpected Death in Patients With Multiple Sclerosis. The American Journal of Forensic Medicine and Pathology 26:3, 244-249
CrossRef614
Ph. Devos. (2005) Étiopathogénie de la maladie d’alzheimer, de la maladie de parkinson et de la sclerose en plaques : le lait n’est pas en cause. Cahiers de Nutrition et de Diététique 40, 54-56
CrossRef615
Hans-Peter Hartung. (2005) Early treatment and dose optimisation. Journal of Neurology 252:S3, iii44-iii50
CrossRef616
Thomas Misgeld. (2005) Death of an axon: studying axon loss in development and disease. Histochemistry and Cell Biology 124:3-4, 189-196
CrossRef617
Wolfgang Brück. (2005) Clinical implications of neuropathological findings in multiple sclerosis. Journal of Neurology 252:S3, iii10-iii14
CrossRef618
Fred Lublin. (2005) History of modern multiple sclerosis therapy. Journal of Neurology 252:S3, iii3-iii9
CrossRef619
Dongwei Wang, Margaret M. Ayers, Deanne V. Catmull, Lisa J. Hazelwood, Claude C.A. Bernard, Jacqueline M. Orian. (2005) Astrocyte-associated axonal damage in pre-onset stages of experimental autoimmune encephalomyelitis. Glia 51:3, 235-240
CrossRef620
Jihong Xu, Paul D. Storer, Janet A. Chavis, Michael K. Racke, Paul D. Drew. (2005) Agonists for the peroxisome proliferator-activated receptor-α and the retinoid X receptor inhibit inflammatory responses of microglia. Journal of Neuroscience Research 81:3, 403-411
CrossRef621
Fabrizio Giuliani, Sue Anne Fu, Luanne M. Metz, V. Wee Yong. (2005) Effective combination of minocycline and interferon-β in a model of multiple sclerosis. Journal of Neuroimmunology 165:1-2, 83-91
CrossRef622
Emma East, David Baker, Gareth Pryce, H. Roger Lijnen, M. Louise Cuzner, Djordje Gverić. (2005) A Role for the Plasminogen Activator System in Inflammation and Neurodegeneration in the Central Nervous System during Experimental Allergic Encephalomyelitis. The American Journal of Pathology 167:2, 545-554
CrossRef623
C. Engel, B. Greim, U. K. Zettl. (2005) Kognitive Defizite bei Multipler Sklerose. Der Nervenarzt 76:8, 943-953
CrossRef624
Alberto Perez-Bouza, Tamara Glaser, Oliver Brüstle. (2005) ES Cell-Derived Glial Precursors Contribute to Remyelination in Acutely Demyelinated Spinal Cord Lesions. Brain Pathology 15:3, 208-216
CrossRef625
Olga Ciccarelli, Ahmed T. Toosy, Simon J. Hickman, Geoff J.M. Parker, Claudia A.M. Wheeler-Kingshott, David H. Miller, Alan J. Thompson. (2005) Optic radiation changes after optic neuritis detected by tractography-based group mapping. Human Brain Mapping 25:3, 308-316
CrossRef626
Hans Lassmann. (2005) Multiple Sclerosis Pathology: Evolution of Pathogenetic Concepts. Brain Pathology 15:3, 217-222
CrossRef627
Richard P. Kennan, Fabiana S. Machado, Sunhee C. Lee, Mahalia S. Desruisseaux, Murray Wittner, Moriya Tsuji, Herbert B. Tanowitz. (2005) Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria. Parasitology Research 96:5, 302-307
CrossRef628
M. Kelly Guyton, J. Michael Wingrave, Anil V. Yallapragada, Gloria G. Wilford, Eric A. Sribnick, Denise D. Matzelle, William R. Tyor, Swapan K. Ray, Naren L. Banik. (2005) Upregulation of calpain correlates with increased neurodegeneration in acute experimental auto-immune encephalomyelitis. Journal of Neuroscience Research 81:1, 53-61
CrossRef629
Michael P. Sanfilipo, Ralph H.B. Benedict, Jitendra Sharma, Bianca Weinstock-Guttman, Rohit Bakshi. (2005) The relationship between whole brain volume and disability in multiple sclerosis: A comparison of normalized gray vs. white matter with misclassification correction. NeuroImage 26:4, 1068-1077
CrossRef630
Domenico M Mezzapesa, Marco Rovaris, Massimo Filippi. (2005) Glatiramer acetate in multiple sclerosis. Expert Review of Neurotherapeutics 5:4, 451-458
CrossRef631
A KUTZELNIGG, H LASSMANN. (2005) Cortical lesions and brain atrophy in MS. Journal of the Neurological Sciences 233:1-2, 55-59
CrossRef632
I COMAN, G BARBIN, P CHARLES, B ZALC, C LUBETZKI. (2005) Axonal signals in central nervous system myelination, demyelination and remyelination. Journal of the Neurological Sciences 233:1-2, 67-71
CrossRef633
J TROTTER. (2005) NG2-positive cells in CNS function and the pathological role of antibodies against NG2 in demyelinating diseases. Journal of the Neurological Sciences 233:1-2, 37-42
CrossRef634
Elimor Brand-Schieber, Peter Werner, Dumitru A. Iacobas, Sanda Iacobas, Michelle Beelitz, Stuart L. Lowery, David C. Spray, Eliana Scemes. (2005) Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis. Journal of Neuroscience Research 80:6, 798-808
CrossRef635
G LYCKLAMAANIJEHOLT. (2005) Reduction of brain volume in MS. MRI and pathology findings. Journal of the Neurological Sciences 233:1-2, 199-202
CrossRef636
R LINKER, M SENDTNER, R GOLD. (2005) Mechanisms of axonal degeneration in EAE—lessons from CNTF and MHC I knockout mice. Journal of the Neurological Sciences 233:1-2, 167-172
CrossRef637
D BECHTOLD, K SMITH. (2005) Sodium-mediated axonal degeneration in inflammatory demyelinating disease. Journal of the Neurological Sciences 233:1-2, 27-35
CrossRef638
M INGLESE, B BENEDETTI, M FILIPPI. (2005) The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis. Journal of the Neurological Sciences 233:1-2, 15-19
CrossRef639
M COLEMAN, R ADALBERT, B BEIROWSKI. (2005) Neuroprotective strategies in MS: Lessons from C57BL/ mice. Journal of the Neurological Sciences 233:1-2, 133-138
CrossRef640
T OLSSON, F PIEHL, M SWANBERG, O LIDMAN. (2005) Genetic dissection of neurodegeneration and CNS inflammation. Journal of the Neurological Sciences 233:1-2, 99-108
CrossRef641
P STYS. (2005) General mechanisms of axonal damage and its prevention. Journal of the Neurological Sciences 233:1-2, 3-13
CrossRef642
A PETZOLD. (2005) Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss. Journal of the Neurological Sciences 233:1-2, 183-198
CrossRef643
N DESTEFANO, M BARTOLOZZI, L GUIDI, M STROMILLO, A FEDERICO. (2005) Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis. Journal of the Neurological Sciences 233:1-2, 203-208
CrossRef644
M ROVARIS, G COMI, M FILIPPI. (2005) Can glatiramer acetate reduce brain atrophy development in multiple sclerosis?. Journal of the Neurological Sciences 233:1-2, 139-143
CrossRef645
Minodora O. Totoiu, Hans S. Keirstead. (2005) Spinal cord injury is accompanied by chronic progressive demyelination. The Journal of Comparative Neurology 486:4, 373-383
CrossRef646
J. Haas, M. Firzlaff. (2005) Twenty-four-month comparison of immunomodulatory treatments - a retrospective open label study in 308 RRMS patients treated with beta interferons or glatiramer acetate (CopaxoneR). European Journal of Neurology 12:6, 425-431
CrossRef647
Laura Leyva, Oscar Fernández, Maria Fedetz, Eva Blanco, Victoria E. Fernández, Begoña Oliver, Antonio León, Maria-Jesus Pinto-Medel, Cristobalina Mayorga, Miguel Guerrero, Gloria Luque, Antonio Alcina, Fuencisla Matesanz. (2005) IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. Journal of Neuroimmunology 163:1-2, 165-171
CrossRef648
Massimo Filippi, Andrea Falini, Douglas L. Arnold, Franz Fazekas, Oded Gonen, Jack H. Simon, Vincent Dousset, Mario Savoiardo, Jerry S. Wolinsky. (2005) Magnetic resonance techniques for the in vivo assessment of multiple sclerosis pathology: Consensus report of the white matter study group. Journal of Magnetic Resonance Imaging 21:6, 669-675
CrossRef649
RADMILA FILIPOVIĆ, NADA ZEČEVIĆ. (2005) Interaction between Microglia and Oligodendrocyte Cell Progenitors Involves Golli Proteins. Annals of the New York Academy of Sciences 1048:1, 166-174
CrossRef650
Sheng-Kwei Song, Jun Yoshino, Tuan Q. Le, Shiow-Jiuan Lin, Shu-Wei Sun, Anne H. Cross, Regina C. Armstrong. (2005) Demyelination increases radial diffusivity in corpus callosum of mouse brain. NeuroImage 26:1, 132-140
CrossRef651
Arnaud Nicot, Michael Kurnellas, Stella Elkabes. (2005) Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis. European Journal of Neuroscience 21:10, 2660-2670
CrossRef652
Bernhard K. Mueller, Helmut Mack, Nicole Teusch. (2005) Rho kinase, a promising drug target for neurological disorders. Nature Reviews Drug Discovery 4:5, 387-398
CrossRef653
Muriel B. Sättler, Ricarda Diem, Doron Merkler, Iris Demmer, Ina Boger, Christine Stadelmann, Mathias Bähr. (2005) Simvastatin treatment does not protect retinal ganglion cells from degeneration in a rat model of autoimmune optic neuritis. Experimental Neurology 193:1, 163-171
CrossRef654
Fei Ren, Ian O. Smith, Melissa J. Baumann, Eldon D. Case. (2005) Three-Dimensional Microstructural Characterization of Porous Hydroxyapatite Using Confocal Laser Scanning Microscopy. International Journal of Applied Ceramic Technology 2:3, 200-211
CrossRef655
Mark J. Tullman, Fred D. Lublin. (2005) Combination therapy in multiple sclerosis. Current Neurology and Neuroscience Reports 5:3, 245-248
CrossRef656
Richard M. Ransohoff, Bruce D. Trapp. (2005) Taking Two TRAILS. Neuron 46:3, 355-356
CrossRef657
Orhan Aktas, Alina Smorodchenko, Stefan Brocke, Carmen Infante-Duarte, Ulf Schulze Topphoff, Johannes Vogt, Timour Prozorovski, Susanne Meier, Venera Osmanova, Elena Pohl, Ingo Bechmann, Robert Nitsch, Frauke Zipp. (2005) Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL. Neuron 46:3, 421-432
CrossRef658
Fabrizio G. Mastronardi, Mario A. Moscarello. (2005) Molecules affecting myelin stability: A novel hypothesis regarding the pathogenesis of multiple sclerosis. Journal of Neuroscience Research 80:3, 301-308
CrossRef659
Carlos Matute, Fernando Pérez-Cerdá. (2005) Multiple sclerosis: novel perspectives on newly forming lesions. Trends in Neurosciences 28:4, 173-175
CrossRef660
Jerome J.A. Hendriks, Charlotte E. Teunissen, Helga E. de Vries, Christine D. Dijkstra. (2005) Macrophages and neurodegeneration. Brain Research Reviews 48:2, 185-195
CrossRef661
David A. Hafler, Jacqueline M. Slavik, David E. Anderson, Kevin C. O'Connor, Philip De Jager, Clare Baecher-Allan. (2005) Multiple sclerosis. Immunological Reviews 204:1, 208-231
CrossRef662
Mireia Sospedra, Roland Martin. (2005) IMMUNOLOGY OF MULTIPLE SCLEROSIS*. Annual Review of Immunology 23:1, 683-747
CrossRef663
JAMES A. SHARPE, KYLEN MCREELIS, AGNES M.F. WONG. (2005) Recovery of Peripheral Versus Central Nerves Identified by Saccadic Velocity After Abducens Neuropathy. Annals of the New York Academy of Sciences 1039:1, 417-429
CrossRef664
Daniel B Drachman, Robert A Brodsky. (2005) High-dose therapy for autoimmune neurologic diseases. Current Opinion in Oncology 17:2, 83-88
CrossRef665
Ikuru Yazawa, Benoit I. Giasson, Ryogen Sasaki, Bin Zhang, Sonali Joyce, Kunihiro Uryu, John Q. Trojanowski, Virginia M.-Y. Lee. (2005) Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration. Neuron 45:6, 847-859
CrossRef666
Radmila Filipovic, Nada Zecevic. (2005) Lipopolysaccharide affects Golli expression and promotes proliferation of oligodendrocyte progenitors. Glia 49:4, 457-466
CrossRef667
Alastair Wilkins, Alastair Compston. (2005) Trophic factors attenuate nitric oxide mediated neuronal and axonal injury in vitro: roles and interactions of mitogen-activated protein kinase signalling pathways. Journal of Neurochemistry 92:6, 1487-1496
CrossRef668
A. Petzold, K. Rejdak, A. Belli, J. Sen, G. Keir, N. Kitchen, M. Smith, E.J. Thompson. (2005) Axonal Pathology in Subarachnoid and Intracerebral Hemorrhage. Journal of Neurotrauma 22:3, 407-414
CrossRef669
Catherine Fressinaud. (2005) Repeated injuries dramatically affect cells of the oligodendrocyte lineage: Effects of PDGF and NT-3 in vitro. Glia 49:4, 555-566
CrossRef670
Anthony Traboulsee, Guojun Zhao, David K.B. Li. (2005) Neuroimaging in multiple sclerosis. Neurologic Clinics 23:1, 131-148
CrossRef671
Orhun H. Kantarci, Brian G. Weinshenker. (2005) Natural history of multiple sclerosis. Neurologic Clinics 23:1, 17-38
CrossRef672
Claudia F. Lucchinetti, Joseph Parisi, Wolfgang Bruck. (2005) The pathology of multiple sclerosis. Neurologic Clinics 23:1, 77-105
CrossRef673
John W. Peterson, Bruce D. Trapp. (2005) Neuropathobiology of multiple sclerosis. Neurologic Clinics 23:1, 107-129
CrossRef674
H. Vrenken, F. Barkhof, B.M.J. Uitdehaag, J.A. Castelijns, C.H. Polman, P.J.W. Pouwels. (2005) MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter. Magnetic Resonance in Medicine 53:2, 256-266
CrossRef675
Almeras Lionel, J. de Seze, Lefranc Didier, Fily-Nalewajk Sandrine, Dubucquoi Sylvain, Vermersch Patrick, Prin Lionel. (2005) Evolution of self-reactive IgG antibody repertoires in patients with relapsing-remitting multiple sclerosis. Immunology Letters 97:1, 55-62
CrossRef676
Sandra Ebert, Joachim Gerber, Steffi Bader, Frank Mühlhauser, Katrin Brechtel, Timothy J. Mitchell, Roland Nau. (2005) Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. Journal of Neuroimmunology 159:1-2, 87-96
CrossRef677
Fred D. Lublin. (2005) Clinical features and diagnosis of multiple sclerosis. Neurologic Clinics 23:1, 1-15
CrossRef678
Harold Atkins, Mark Freedman. (2005) Immunoablative therapy as a treatment aggressive multiple sclerosis. Neurologic Clinics 23:1, 273-300
CrossRef679
Matthew J. Craner, Tina G. Damarjian, Shujun Liu, Bryan C. Hains, Albert C. Lo, Joel A. Black, Jia Newcombe, M. Louise Cuzner, Stephen G. Waxman. (2005) Sodium channels contribute to microglia/macrophage activation and function in EAE and MS. Glia 49:2, 220-229
CrossRef680
D. Centonze, S. Rossi, L. Boffa, V. Versace, M. G. Palmieri, M. D. Caramia, G. Bernardi. (2005) CSF from MS patients can induce acute conduction block in the isolated optic nerve. European Journal of Neurology 12:1, 45-48
CrossRef681
F. Aboul-Enein, H. Lassmann. (2005) Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease?. Acta Neuropathologica 109:1, 49-55
CrossRef682
Fabrizio Giuliani, Luanne M. Metz, Tammy Wilson, Yan Fan, Amit Bar-Or, V. Wee Yong. (2005) Additive effect of the combination of glatiramer acetate and minocycline in a model of MS. Journal of Neuroimmunology 158:1-2, 213-221
CrossRef683
Charlotte E Teunissen, Christine Dijkstra, Chris Polman. (2005) Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. The Lancet Neurology 4:1, 32-41
CrossRef684
Paulo Fontoura, Hideki Garren, Lawrence Steinman. (2005) Antigen-Specific Therapies in Multiple Sclerosis: Going Beyond Proteins and Peptides. International Reviews of Immunology 24:5-6, 415-446
CrossRef685
S.J. Jackson, G. Pryce, L.T. Diemel, M.L. Cuzner, D. Baker. (2005) Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation. Neuroscience 134:1, 261-268
CrossRef686
C. Fressinaud, I. Jean, F. Dubas. (2005) Modifications des neurofilaments et des microtubules axonaux en fonction du mécanisme lésionnel : étude pathologique et expérimentale. Revue Neurologique 161:1, 55-60
CrossRef687
Siobhan M Leary, Alan J Thompson. (2005) Primary Progressive Multiple Sclerosis. CNS Drugs 19:5, 369-376
CrossRef688
Pavel Hradílek, Olga Zapletalová, David Doležil, David Školoudík. (2005) Acute Optic Neuritis in Multiple Sclerosis: Evaluation of Hemodynamics in the Ophthalmic Artery with Colour Doppler Imaging. Neuro-Ophthalmology 29:4, 161-164
CrossRef689
Cengiz Akarsu, Funda Uysal Tan, Tuba Kendi. (2004) Color Doppler imaging in optic neuritis with multiple sclerosis. Graefe's Archive for Clinical and Experimental Ophthalmology 242:12, 990-994
CrossRef690
Francesco Patti, Ester Reggio, Filippo Palermo, Teresa Fiorilla, Guido Politi, Alessandra Nicoletti, Arturo Reggio. (2004) Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon beta. Journal of Neurology 251:12, 1502-1506
CrossRef691
Carsten Lukas, Horst K. Hahn, Barbara Bellenberg, Jan Rexilius, Gebhard Schmid, Sebastian K. Schimrigk, Horst Przuntek, Odo K
CrossRef692
Stefano Sotgiu, Maura Pugliatti, Maria Laura Fois, Giannina Arru, Alessandra Sanna, Maria Alessandra Sotgiu, Giulio Rosati. (2004) Genes, environment, and susceptibility to multiple sclerosis. Neurobiology of Disease 17:2, 131-143
CrossRef693
Bertrand Audoin, Jean-Philippe Ranjeva, My Van Au Duong, Danielle Ibarrola, Irina Malikova, Sylviane Confort-Gouny, Elisabeth Soulier, Patrick Viout, Andr
CrossRef694
Gennadij Raivich, Richard Banati. (2004) Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Research Reviews 46:3, 261-281
CrossRef695
J.T. Chen, S. Narayanan, D.L. Collins, S.M. Smith, P.M. Matthews, D.L. Arnold. (2004) Relating neocortical pathology to disability progression in multiple sclerosis using MRI. NeuroImage 23:3, 1168-1175
CrossRef696
T DAMARJIAN, M CRANER, J BLACK, S WAXMAN. (2004) Upregulation and colocalization of p75 and Na1.8 in Purkinje neurons in experimental autoimmune encephalomyelitis. Neuroscience Letters 369:3, 186-190
CrossRef697
Eric Birgbauer, Tadimeti S. Rao, Michael Webb. (2004) Lysolecithin induces demyelination in vitro in a cerebellar slice culture system. Journal of Neuroscience Research 78:2, 157-166
CrossRef698
Massimo Filippi, Marco Rovaris, Matilde Inglese, Frederik Barkhof, Nicola De Stefano, Steve Smith, Giancarlo Comi. (2004) Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial. The Lancet 364:9444, 1489-1496
CrossRef699
Katharina Maier, Christian R. Rau, Maria K. Storch, Muriel B. Sättler, Iris Demmer, Robert Weissert, Naimeh Taheri, Antje V. Kuhnert, Mathias Bähr, Ricarda Diem. (2004) Ciliary Neurotrophic Factor Protects Retinal Ganglion Cells from Secondary Cell Death During Acute Autoimmune Optic Neuritis in Rats. Brain Pathology 14:4, 378-387
CrossRef700
Bert A 't Hart, Jon D Laman, Jan Bauer, Erwin Blezer, Yvette van Kooyk, Rogier Q Hintzen. (2004) Modelling of multiple sclerosis: lessons learned in a non-human primate. The Lancet Neurology 3:10, 588-597
CrossRef701
Trevor J Kilpatrick, Helmut Butzkueven, Ben Emery, Mark Marriott, Bruce V Taylor, Niall Tubridy. (2004) Neuroglial responses to CNS injury: prospects for novel therapeutics. Expert Review of Neurotherapeutics 4:5, 869-878
CrossRef702
Anthony Traboulsee. (2004) MRI: role in optimising treatment. Journal of Neurology 251:S5, v36-v41
CrossRef703
Klaus Schmierer, Francesco Scaravilli, Daniel R. Altmann, Gareth J. Barker, David H. Miller. (2004) Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Annals of Neurology 56:3, 407-415
CrossRef704
Nathalie J. Collignon-Robe, Gilbert T. Feke, Joseph F. Rizzo. (2004) Optic nerve head circulation in nonarteritic anterior ischemic optic neuropathy and optic neuritis. Ophthalmology 111:9, 1663-1672
CrossRef705
Jeroen J.G. Geurts, Frederik Barkhof, Jonas A. Castelijns, Bernard M.J. Uitdehaag, Chris H. Polman, Petra J.W. Pouwels. (2004) Quantitative1H-MRS of healthy human cortex, hippocampus, and thalamus: Metabolite concentrations, quantification precision, and reproducibility. Journal of Magnetic Resonance Imaging 20:3, 366-371
CrossRef706
D. H. Miller, M. Filippi, F. Fazekas, J. L. Frederiksen, P. M. Matthews, X. Montalban, C. H. Polman. (2004) Role of magnetic resonance imaging within diagnostic criteria for multiple sclerosis. Annals of Neurology 56:2, 273-278
CrossRef707
H WEINER. (2004) Immunosuppressive treatment in multiple sclerosis. Journal of the Neurological Sciences 223:1, 1-11
CrossRef708
Bruce G. Gold, Jan Voda, Xiaolin Yu, Gabriel McKeon, Dennis N. Bourdette. (2004) FK506 and a nonimmunosuppressant derivative reduce axonal and myelin damage in experimental autoimmune encephalomyelitis: Neuroimmunophilin ligand-mediated neuroprotection in a model of multiple sclerosis. Journal of Neuroscience Research 77:3, 367-377
CrossRef709
Michael Webb, Chui-Se Tham, Fen-Fen Lin, Karen Lariosa-Willingham, Naichen Yu, Jeffrey Hale, Suzanne Mandala, Jerold Chun, Tadimeti S Rao. (2004) Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice. Journal of Neuroimmunology 153:1-2, 108-121
CrossRef710
N GHOSH, G DELUCA, M ESIRI. (2004) Evidence of axonal damage in human acute demyelinating diseases. Journal of the Neurological Sciences 222:1-2, 29-34
CrossRef711
Margaret M Ayers, Lisa J Hazelwood, Deanne V Catmull, Dongwei Wang, Quinn McKormack, Claude C.A Bernard, Jacqueline M Orian. (2004) Early glial responses in murine models of multiple sclerosis. Neurochemistry International 45:2-3, 409-419
CrossRef712
A. Kroner, M. Maurer, S. Loserth, C. Kleinschnitz, B. Hemmer, B. Rosche, K.V. Toyka, P. Rieckmann. (2004) Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in patients with multiple sclerosis. Tissue Antigens 64:1, 70-73
CrossRef713
Alireza Minagar, Eduardo Gonzalez Toledo, J. Steven Alexander, Roger E. Kelley. (2004) Pathogenesis of Brain and Spinal Cord Atrophy in Multiple Sclerosis. Journal of Neuroimaging 14, 5S-10S
CrossRef714
Gordon Francis. (2004) Benefit-risk assessment of interferon-b therapy for relapsing multiple sclerosis. Expert Opinion on Drug Safety 3:4, 289-303
CrossRef715
B. Bielekova. (2004) Development of biomarkers in multiple sclerosis. Brain 127:7, 1463-1478
CrossRef716
Anuradha Chakrabarty, Marsha M. Danley, Steven M. LeVine. (2004) Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2? in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Journal of Neuroscience Research 76:6, 822-833
CrossRef717
Eilhard Mix, Saleh Ibrahim, Jens Pahnke, Dirk Koczan, Christian Sina, Tobias Böttcher, Hans-Jürgen Thiesen, Arndt Rolfs. (2004) Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process. Journal of Neuroimmunology 151:1-2, 158-170
CrossRef718
J.M. Edgar, J. Garbern. (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved. Journal of Neuroscience Research 76:5, 593-598
CrossRef719
Kenneth E Hill, Lauren V Zollinger, Hilary E Watt, Noel G Carlson, John W Rose. (2004) Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage. Journal of Neuroimmunology 151:1-2, 171-179
CrossRef720
A. Saari, U. Tolonen, E. Pääkkö, K. Suominen, J. Pyhtinen, K. Sotaniemi, V. Myllylä. (2004) Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS. Clinical Neurophysiology 115:6, 1473-1478
CrossRef721
Gianvito Martino. (2004) How the brain repairs itself: new therapeutic strategies in inflammatory and degenerative CNS disorders. The Lancet Neurology 3:6, 372-378
CrossRef722
A MARTINEZYELAMOS. (2004) Tau protein in cerebrospinal fluid: a possible marker of poor outcome in patients with early relapsing-remitting multiple sclerosis. Neuroscience Letters 363:1, 14-17
CrossRef723
Anthony P. Nicholas, Thiagarajan Sambandam, Joshua D. Echols, Wallace W. Tourtellotte. (2004) Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis. The Journal of Comparative Neurology 473:1, 128-136
CrossRef724
David A. Bechtold, Raju Kapoor, Kenneth J. Smith. (2004) Axonal protection using flecainide in experimental autoimmune encephalomyelitis. Annals of Neurology 55:5, 607-616
CrossRef725
Peter Flachenecker. (2004) Disease-modifying drugs for the early treatment of multiple sclerosis. Expert Review of Neurotherapeutics 4:3, 455-463
CrossRef726
Jaume Sastre-Garriga, Gordon T Ingle, Declan T Chard, Lluı́s Ramió-Torrentà, David H Miller, Alan J Thompson. (2004) Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis. NeuroImage 22:1, 353-359
CrossRef727
Peter K. Stys. (2004) Axonal degeneration in multiple sclerosis: Is it time for neuroprotective strategies?. Annals of Neurology 55:5, 601-603
CrossRef728
N Lev. (2004) Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice. Neuroscience Letters 359:3, 139-142
CrossRef729
Martin Kerschensteiner, Christine Stadelmann, Bigna S. Buddeberg, Doron Merkler, Florence M. Bareyre, Daniel C. Anthony, Christopher Linington, Wolfgang Brück, Martin E. Schwab. (2004) Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis. The American Journal of Pathology 164:4, 1455-1469
CrossRef730
Muriel Hobom, Maria K. Storch, Robert Weissert, Katharina Maier, Anand Radhakrishnan, Birgit Kramer, Mathias Bähr, Ricarda Diem. (2004) Mechanisms and Time Course of Neuronal Degeneration in Experimental Autoimmune Encephalomyelitis. Brain Pathology 14:2, 148-157
CrossRef731
David H. Miller. (2004) Biomarkers and surrogate outcomes in neurodegenerative disease: Lessons from multiple sclerosis. NeuroRX 1:2, 284-294
CrossRef732
Michael H. Barnett, John W. Prineas. (2004) Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Annals of Neurology 55:4, 458-468
CrossRef733
Martin Stangel. (2004) Remyelinating and neuroprotective treatments in multiple sclerosis. Expert Opinion on Investigational Drugs 13:4, 331-347
CrossRef734
Matilde Inglese, Yulin Ge, Massimo Filippi, Andrea Falini, Robert I. Grossman, Oded Gonen. (2004) Indirect evidence for early widespread gray matter involvement in relapsing–remitting multiple sclerosis. NeuroImage 21:4, 1825-1829
CrossRef735
David A. Hafler. (2004) Multiple sclerosis. Journal of Clinical Investigation 113:6, 788-794
CrossRef736
Lotti Tajouri, Linda Ferreira, Micky Ovcaric, Rob Curtain, Rod Lea, Peter Csurhes, Michael P. Pender, Lyn R. Griffiths. (2004) Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population. Journal of the Neurological Sciences 218:1-2, 25-28
CrossRef737
STEVEN M. LEVINE, ANURADHA CHAKRABARTY. (2004) The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis. Annals of the New York Academy of Sciences 1012:1, 252-266
CrossRef738
Jacques De Keyser, Esther Zeinstra, Nadine Wilczak. (2004) Astrocytic β2-adrenergic receptors and multiple sclerosis. Neurobiology of Disease 15:2, 331-339
CrossRef739
Hans Lassmann, Richard M. Ransohoff. (2004) The CD4–Th1 model for multiple sclerosis: a crucial re-appraisal. Trends in Immunology 25:3, 132-137
CrossRef740
P BRYANT, C GEIS, A MOROZ, B OANEILL, R BOGEY. (2004) Stroke and neurodegenerative disorders. 4. neurodegenerative disorders. Archives of Physical Medicine and Rehabilitation 85, 21-33
CrossRef741
Alicia L Degano, Yanina Ditamo, German A Roth. (2004) Neuronal antigens modulate the immune response associated with experimental autoimmune encephalomyelitis. Immunology and Cell Biology 82:1, 17-23
CrossRef742
David A Dyment, George C Ebers, A Dessa Sadovnick. (2004) Genetics of multiple sclerosis. The Lancet Neurology 3:2, 104-110
CrossRef743
Bert A. 't Hart, Jack Vogels, Jan Bauer, Herbert P.M. Brok, Erwin Blezer. (2004) Non-invasive measurement of brain damage in a primate model of multiple sclerosis. Trends in Molecular Medicine 10:2, 85-91
CrossRef744
Athena Kalyvas, Samuel David. (2004) Cytosolic Phospholipase A2 Plays a Key Role in the Pathogenesis of Multiple Sclerosis-like Disease. Neuron 41:3, 323-335
CrossRef745
Nina Dr
CrossRef746
Michihiro Fujiwara, Nobuaki Egashira. (2004) New Perspectives in the Studies on Endocannabinoid and Cannabis: Abnormal Behaviors Associate With CB1 Cannabinoid Receptor and Development of Therapeutic Application. Journal of Pharmacological Sciences 96:4, 362-366
CrossRef747
Oscar Fern??ndez. (2004) Interferons in Relapsing-Remitting Multiple Sclerosis. CNS Drugs 18:15, 1057-1070
CrossRef748
David H. Miller. (2004) Biomarkers and surrogate outcomes in neurodegenerative disease: Lessons from multiple sclerosis. NeuroRX 1:2, 284
CrossRef749
Samantha S. Soldan, Ana Isabel Alvarez Retuerto, Nancy L. Sicotte, Rhonda R. Voskuhl. (2004) Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosis. Journal of Neuroimmunology 146:1-2, 209-215
CrossRef750
Per Soelberg Sorensen. (2004) Early-Stage Multiple Sclerosis. Drugs 64:18, 2021-2029
CrossRef751
R. Höftberger, F. Aboul-Enein, W. Brueck, C. Lucchinetti, M. Rodriguez, M. Schmidbauer, K. Jellinger, H. Lassmann. (2004) Expression of Major Histocompatibility Complex class l Molecules on the Different Cell Types in Multiple Sclerosis Lesions. Brain Pathology 14:1, 43-50
CrossRef752
Christopher B. Lock, Renu A. Heller. (2003) Gene microarray analysis of multiple sclerosis lesions. Trends in Molecular Medicine 9:12, 535-541
CrossRef753
X. Lin, L. D. Blumhardt, C. S. Constantinescu. (2003) The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study. Acta Neurologica Scandinavica 108:6, 401-406
CrossRef754
Laurent Magy, Caroline Mertens, Virginia Avellana-Adalid, Mahamane Keita, François Lachapelle, Brahim Nait-Oumesmar, Bertrand Fontaine, Anne Baron-Van Evercooren. (2003) Inducible expression of FGF2 by a rat oligodendrocyte precursor cell line promotes CNS myelination in vitro. Experimental Neurology 184:2, 912-922
CrossRef755
PAUL D. DREW, JANET A. CHAVIS, RENU BHATT. (2003) Sex Steroid Regulation of Microglial Cell Activation. Annals of the New York Academy of Sciences 1007:1, 329-334
CrossRef756
Y Gilgun-Sherki. (2003) Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis. Brain Research 989:2, 196-204
CrossRef757
Sabine Golde, Alasdair Coles, Jonathan A. Lindquist, Alastair Compston. (2003) Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro. European Journal of Neuroscience 18:9, 2527-2537
CrossRef758
R Handa. (2003) In vivo proton magnetic resonance spectroscopy (MRS) and single photon emission computerized tomography (SPECT) in systemic lupus erythematosus (SLE). Magnetic Resonance Imaging 21:9, 1033-1037
CrossRef759
Michel Revel. (2003) Interferon-β in the treatment of relapsing–remitting multiple sclerosis. Pharmacology & Therapeutics 100:1, 49-62
CrossRef760
James L Salzer. (2003) Polarized Domains of Myelinated Axons. Neuron 40:2, 297-318
CrossRef761
John Kirk, Jonnie Plumb, Meenakshi Mirakhur, Stephen McQuaid. (2003) Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. The Journal of Pathology 201:2, 319-327
CrossRef762
Alexandra Weber, Carmen Infante-Duarte, Stephen Sawcer, Efrosini Setakis, Judith Bellmann-Strobl, Anke Hensiek, Sandra Rueckert, Constanze Schoenemann, Kjartan Benediktsson, Alastair Compston, Frauke Zipp. (2003) A genome-wide German screen for linkage disequilibrium in multiple sclerosis. Journal of Neuroimmunology 143:1-2, 79-83
CrossRef763
Dan Sunnemark, Sana Eltayeb, Erik Wallström, Lena Appelsved, Åsa Malmberg, Hans Lassmann, Anders Ericsson-Dahlstrand, Fredrik Piehl, Tomas Olsson. (2003) Differential Expression of the Chemokine Receptors CX3CR1 and CCR1 by Microglia and Macrophages in Myelin-Oligodendrocyte-Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis. Brain Pathology 13:4, 617-629
CrossRef764
Roland G. Henry, Joonmi Oh, Sarah J. Nelson, Daniel Pelletier. (2003) Directional diffusion in relapsing-remitting multiple sclerosis: A possible in vivo signature of Wallerian degeneration. Journal of Magnetic Resonance Imaging 18:4, 420-426
CrossRef765
Y Gilgun-Sherki. (2003) Axonal damage is reduced following glatiramer acetate treatment in C57/bl mice with chronic-induced experimental autoimmune encephalomyelitis. Neuroscience Research 47:2, 201-207
CrossRef766
R Kumar. (2003) Magnetization transfer and T2 quantitation in normal appearing cortical gray matter and white matter adjacent to focal abnormality in patients with traumatic brain injury. Magnetic Resonance Imaging 21:8, 893-899
CrossRef767
B Kornek. (2003) Neuropathology of multiple sclerosis—new concepts. Brain Research Bulletin 61:3, 321-326
CrossRef768
J Satoh. (2003) Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis. Journal of the Neurological Sciences 212:1-2, 11-20
CrossRef769
Berger, Thomas, Rubner, Paul, Schautzer, Franz, Egg, Robert, Ulmer, Hanno, Mayringer, Irmgard, Dilitz, Erika, Deisenhammer, Florian, Reindl, Markus, . (2003) Antimyelin Antibodies as a Predictor of Clinically Definite Multiple Sclerosis after a First Demyelinating Event. New England Journal of Medicine 349:2, 139-145
Full Text770
E FROHMAN. (2003) Multiple sclerosis. Medical Clinics of North America 87:4, 867-897
CrossRef771
Isabelle Jean, Catherine Fressinaud. (2003) Spontaneous central nervous system remyelination is not altered in NFH-lacZ transgenic mice after chemical demyelination. Journal of Neuroscience Research 73:1, 54-60
CrossRef772
A Petzold. (2003) A specific ELISA for measuring neurofilament heavy chain phosphoforms. Journal of Immunological Methods 278:1-2, 179-190
CrossRef773
Matilde Inglese, Belinda S.Y. Li, Henry Rusinek, James S. Babb, Robert I. Grossman, Oded Gonen. (2003) Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. Magnetic Resonance in Medicine 50:1, 190-195
CrossRef774
CHRISTINE DALY, BARRETT J. ROLLINS. (2003) Monocyte Chemoattractant Protein-1 (CCL2) in Inflammatory Disease and Adaptive Immunity: Therapeutic Opportunities and Controversies. Microcirculation 10:3-4, 247-257
CrossRef775
Milena Penkowa, Juan Hidalgo. (2003) Treatment with metallothionein prevents demyelination and axonal damage and increases oligodendrocyte precursors and tissue repair during experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 72:5, 574-586
CrossRef776
Robert A. Pon, Mark S. Freedman. (2003) Study of Herpesvirus saimiri immortalization of γδ T cells derived from peripheral blood and CSF of multiple sclerosis patients. Journal of Neuroimmunology 139:1-2, 119-132
CrossRef777
Paolo A. Muraro, Riccardo Cassiani Ingoni, Roland Martin. (2003) Hematopoietic stem cell transplantation for multiple sclerosis: current status and future challenges. Current Opinion in Neurology 16:3, 299-305
CrossRef778
Bernhard Hemmer, Bernd Kieseier, Sabine Cepok, Hans-Peter Hartung. (2003) New immunopathologic insights into multiple sclerosis. Current Neurology and Neuroscience Reports 3:3, 246-255
CrossRef779
Bert A. ʼt Hart, Sandra Amor. (2003) The use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the central nervous system. Current Opinion in Neurology 16:3, 375-383
CrossRef780
Claire L Gibson, Gavin J Clowry. (2003) The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat: a model for periventricular leukomalacia. International Journal of Developmental Neuroscience 21:4, 171-182
CrossRef781
Kottil W. Rammohan. (2003) Axonal injury in multiple sclerosis. Current Neurology and Neuroscience Reports 3:3, 231-237
CrossRef782
Bernd C. Kieseier, Hans-Peter Hartung. (2003) Multiple paradigm shifts in multiple sclerosis. Current Opinion in Neurology 16:3, 247-252
CrossRef783
Harald Neumann. (2003) Molecular mechanisms of axonal damage in inflammatory central nervous system diseases. Current Opinion in Neurology 16:3, 267-273
CrossRef784
A. Gielen, M. Khademi, S. Muhallab, T. Olsson, F. Piehl. (2003) Increased Brain-Derived Neurotrophic Factor Expression in White Blood Cells of Relapsing-Remitting Multiple Sclerosis Patients. Scandinavian Journal of Immunology 57:5, 493-497
CrossRef785
J. C. Debruyne, J. Versijpt, K. J. Van Laere, F. De Vos, J. Keppens, K. Strijckmans, E. Achten, G. Slegers, R. A. Dierckx, J. Korf, J. L. De Reuck. (2003) PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. European Journal of Neurology 10:3, 257-264
CrossRef786
A. Petzold, D. Baker, G. Pryce, G. Keir, E.J. Thompson, G. Giovannoni. (2003) Quantification of neurodegeneration by measurement of brain-specific proteins. Journal of Neuroimmunology 138:1-2, 45-48
CrossRef787
Corinne G. Jolivalt, Randy B. Howard, Long S. Chen, Andrew P. Mizisin, Ching-San Lai. (2003) A novel nitric oxide scavenger in combination with cyclosporine A ameliorates experimental autoimmune encephalomyelitis progression in mice. Journal of Neuroimmunology 138:1-2, 56-64
CrossRef788
Emmanuelle Waubant. (2003) Emerging disease modifying therapies for multiple sclerosis. Expert Opinion on Emerging Drugs 8:1, 145-161
CrossRef789
Bing Zhu, Liqing Luo, G. R. Wayne Moore, Donald W. Paty, Max S. Cynader. (2003) Dendritic and Synaptic Pathology in Experimental Autoimmune Encephalomyelitis. The American Journal of Pathology 162:5, 1639-1650
CrossRef790
R Bermel. (2003) A semiautomated measure of whole-brain atrophy in multiple sclerosis. Journal of the Neurological Sciences 208:1-2, 57-65
CrossRef791
Ikuo Tsunoda, Li-Qing Kuang, Jane E. Libbey, Robert S. Fujinami. (2003) Axonal Injury Heralds Virus-Induced Demyelination. The American Journal of Pathology 162:4, 1259-1269
CrossRef792
Maria A Rocca, Domenico M Mezzapesa, Andrea Falini, Angelo Ghezzi, Vittorio Martinelli, Giuseppe Scotti, Giancarlo Comi, Massimo Filippi. (2003) Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis. NeuroImage 18:4, 847-855
CrossRef793
Martin Kerschensteiner, Christine Stadelmann, Georg Dechant, Hartmut Wekerle, Reinhard Hohlfeld. (2003) Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Annals of Neurology 53:3, 292-304
CrossRef794
C Cid, J.C Álvarez-Cermeño, I Regidor, J Plaza, M Salinas, A Alcázar. (2003) Caspase inhibitors protect against neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients. Journal of Neuroimmunology 136:1-2, 119-124
CrossRef795
Jeremy Alley, Sergey Khasabov, Don Simone, Alvin Beitz, Moses Rodriguez, M.Kariuki Njenga. (2003) More severe neurologic deficits in SJL/J male than female mice following Theiler’s virus-induced CNS demyelination. Experimental Neurology 180:1, 14-24
CrossRef796
Robert H Swanborg, Judith A Whittum-Hudson, Alan P Hudson. (2003) Infectious agents and multiple sclerosis—are Chlamydia pneumoniae and human herpes virus 6 involved?. Journal of Neuroimmunology 136:1-2, 1-8
CrossRef797
C Bjartmar. (2003) Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. Journal of the Neurological Sciences 206:2, 165-171
CrossRef798
G Wayne Moore. (2003) MRI-clinical correlations: more than inflammation alone-what can MRI contribute to improve the understanding of pathological processes in MS?. Journal of the Neurological Sciences 206:2, 175-179
CrossRef799
M Clanet. (2003) Clinical–MRI correlations in the secondary progressive phase of MS: lessons from the treatment trials. Journal of the Neurological Sciences 206:2, 139-144
CrossRef800
H Lassmann. (2003) Hypoxia-like tissue injury as a component of multiple sclerosis lesions. Journal of the Neurological Sciences 206:2, 187-191
CrossRef801
Stephen G. Waxman. (2003) Nitric oxide and the axonal death cascade. Annals of Neurology 53:2, 150-153
CrossRef802
Raju Kapoor, Meirion Davies, Paul A. Blaker, Susan M. Hall, Kenneth J. Smith. (2003) Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration. Annals of Neurology 53:2, 174-180
CrossRef803
Andreia C Gomes, Gun Jönsson, Susanna Mjörnheim, Tomas Olsson, Jan Hillert, Alf Grandien. (2003) Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis. Journal of Neuroimmunology 135:1-2, 126-134
CrossRef804
John R. Corboy, Douglas S. Goodin, Elliot M. Frohman. (2003) Disease-modifying therapies for multiple sclerosis. Current Treatment Options in Neurology 5:1, 35-54
CrossRef805
Haidong Dong, Scott E. Strome, Eric L. Matteson, Kevin G. Moder, Dallas B. Flies, Gefeng Zhu, Hideto Tamura, Colin L.W. Driscoll, Lieping Chen. (2003) Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. Journal of Clinical Investigation 111:3, 363-370
CrossRef806
Don J. Mahad, Richard M. Ransohoff. (2003) The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Seminars in Immunology 15:1, 23-32
CrossRef807
Mario Quarantelli, Andrea Ciarmiello, Vincenzo Brescia Morra, Giuseppe Orefice, Michele Larobina, Roberta Lanzillo, Vittorio Schiavone, Elena Salvatore, Bruno Alfano, Arturo Brunetti. (2003) Brain tissue volume changes in relapsing-remitting multiple sclerosis: correlation with lesion load. NeuroImage 18:2, 360-366
CrossRef808
Sarlota Mesaros, Jelena Drulovic, Zvonimir Levic. (2003) Clinical and neurophysiological findings in oligoclonal band negative multiple sclerosis patients. Srpski arhiv za celokupno lekarstvo 131:3-4, 122-126
CrossRef809
Heike Siebert, Wolfgang Brück. (2003) The role of cytokines and adhesion molecules in axon degeneration after peripheral nerve axotomy: a study in different knockout mice. Brain Research 960:1-2, 152-156
CrossRef810
Peter Flachenecker, Peter Rieckmann. (2003) Early Intervention in Multiple Sclerosis. Drugs 63:15, 1525-1533
CrossRef811
Marco Rovaris, Massimo Filippi. (2003) Interventions for the Prevention of Brain Atrophy in Multiple Sclerosis. CNS Drugs 17:8, 563-575
CrossRef812
Carl Bjartmar, Bruce D. Trapp. (2003) Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotoxicity Research 5:1-2, 157-164
CrossRef813
Mohammed K Sharief. (2003) Dose and Frequency of Administration of Interferon-?? Affect its Efficacy in Multiple Sclerosis. Clinical Drug Investigation 23:9, 551-559
CrossRef814
Richard A. Lewis, Robert P. Lisak. (2003) ?Rebooting? the immune system with cyclophosphamide: Taking risks for a ?cure??. Annals of Neurology 53:1, 7-9
CrossRef815
M Renganathan, M Gelderblom, J.A Black, S.G Waxman. (2003) Expression of Nav1.8 sodium channels perturbs the firing patterns of cerebellar purkinje cells. Brain Research 959:2, 235-242
CrossRef816
T. Palomo, R. J. Beninger, R. M. Kostrzewa, T. Archer. (2003) Brain sites of movement disorder: Genetic and environmental agents in neurodevelopmental perturbations. Neurotoxicity Research 5:1-2, 1-26
CrossRef817
Hans Lassmann. 2003. Multiple Sclerosis (MS), Basic Biology. , 241-244.
CrossRef818
Martin Stangel, Hans-Peter Hartung. (2002) Remyelinating strategies for the treatment of multiple sclerosis. Progress in Neurobiology 68:5, 361-376
CrossRef819
D Grenier. (2002) T2 relaxation time histograms in multiple sclerosis. Magnetic Resonance Imaging 20:10, 733-741
CrossRef820
Melissa A. Cosenza, Meng-Liang Zhao, Sai L. Shankar, Bridget Shafit-Zagardo, Sunhee C. Lee. (2002) Up-regulation of MAP2e-expressing oligodendrocytes in the white matter of patients with HIV-1 encephalitis. Neuropathology and Applied Neurobiology 28:6, 480-488
CrossRef821
F. J. Jimenez-Jimenez, J. M. Zurdo, A. Hernanz, S. Medina-Acebron, F. de Bustos, B. Barcenilla, Y. Sayed, L. Ayuso-Peralta. (2002) Tau protein concentrations in cerebrospinal fluid of patients with multiple sclerosis. Acta Neurologica Scandinavica 106:6, 351-354
CrossRef822
Sheng-Kwei Song, Shu-Wei Sun, Michael J. Ramsbottom, Chen Chang, John Russell, Anne H. Cross. (2002) Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water. NeuroImage 17:3, 1429-1436
CrossRef823
Douglas R Jeffery. (2002) Use of adrenocorticosteroid hormones in the treatment of multiple sclerosis. Expert Review of Neurotherapeutics 2:6, 859-866
CrossRef824
Robert H. Swanborg, Judith A. Whittum-Hudson, Alan P. Hudson. (2002) Human herpesvirus 6 and Chlamydia pneumoniae as etiologic agents in multiple sclerosis — a critical review. Microbes and Infection 4:13, 1327-1333
CrossRef825
Paola Sarchielli, Laura Greco, Antonio Stipa, Ardesio Floridi, Virgilio Gallai. (2002) Brain-derived neurotrophic factor in patients with multiple sclerosis. Journal of Neuroimmunology 132:1-2, 180-188
CrossRef826
M. P. Pender, N. P. Wolfe. (2002) Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects. Internal Medicine Journal 32:11, 554-563
CrossRef827
Alessandra Solari, Bernard MJ Uitdehaag, Giorgio Giuliani, Eugenio Pucci, Cristiana Taus, Alessandra Solari. 2002. Aminopyridines for symptomatic treatment in multiple sclerosis. .
CrossRef828
Margit G. Proescholdt, Laura Quigley, Roland Martin, Miles Herkenham. (2002) Immunization with a cannabinoid receptor type 1 peptide results in experimental allergic meningocerebellitis in the Lewis rat: A model for cell-mediated autoimmune neuropathology. Journal of Neuroscience Research 70:2, 150-160
CrossRef829
Albert C. Lo, Joel A. Black, Stephen G. Waxman. (2002) Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. NeuroReport 13:15, 1909-1912
CrossRef830
D Pelletier. (2002) 3-D echo planar 1HMRS imaging in MS: metabolite comparison from supratentorial vs. central brain. Magnetic Resonance Imaging 20:8, 599-606
CrossRef831
Robert Zivadinov, Marino Zorzon. (2002) Is Gadolinium Enhancement Predictive of the Development of Brain Atrophy in Multiple Sclerosis? A Review of the Literature. Journal of Neuroimaging 12:4, 302-309
CrossRef832
Massimo Filippi, Carla Tortorella, Marco Rovaris. (2002) Magnetic Resonance Imaging of Multiple Sclerosis. Journal of Neuroimaging 12:4, 289-301
CrossRef833
P. KIVISÄKK, C. TREBST, Z. LIU, B. H. TUCKY, T. L. SØRENSEN, R. A. RUDICK, M. MACK, R. M. RANSOHOFF. (2002) T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clinical & Experimental Immunology 129:3, 510-518
CrossRef834
Clara M Pelfrey, Anne C Cotleur, Jar-Chi Lee, Richard A Rudick. (2002) Sex differences in cytokine responses to myelin peptides in multiple sclerosis. Journal of Neuroimmunology 130:1-2, 211-223
CrossRef835
K Schaecher, A Rocchini, J Dinkins, D.D Matzelle, N.L Banik. (2002) Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease. Journal of Neuroimmunology 129:1-2, 1-9
CrossRef836
Ming Zhang, Sally S Atherton. (2002) Apoptosis in the retina during MCMV retinitis in immunosuppressed BALB/c mice. Journal of Clinical Virology 25, 137-147
CrossRef837
Kenneth J Smith, Hans Lassmann. (2002) The role of nitric oxide in multiple sclerosis. The Lancet Neurology 1:4, 232-241
CrossRef838
S. Probst-Cousin, D. Kowolik, K. Kuchelmeister, C. Kayser, B. Neundorfer, D. Heuss. (2002) Expression of annexin-1 in multiple sclerosis plaques. Neuropathology and Applied Neurobiology 28:4, 292-300
CrossRef839
G McDonnell. (2002) Primary progressive multiple sclerosis: increasing clarity but many unanswered questions. Journal of the Neurological Sciences 199:1-2, 1-15
CrossRef840
Maria K. Storch, Robert Weissert, Andreas Stefferl, Robert Birnbacher, Erik Wallström, Ingrid Dahlman, Claes Göran Ostensson, Christopher Linington, Tomas Olsson, Hans Lassmann. (2002) MHC Gene Related Effects on Microglia and Macrophages in Experimental Autoimmune Encephalomyelitis Determine the Extent of Axonal Injury. Brain Pathology 12:3, 287-299
CrossRef841
S. Sotgiu, M. Pugliatti, A. Sanna, A. Sotgiu, P. Castiglia, G. Solinas, A. Dolei, C. Serra, B. Bonetti, G. Rosati. (2002) Multiple sclerosis complexity in selected populations: the challenge of Sardinia, insular Italy1. European Journal of Neurology 9:4, 329-341
CrossRef842
Youngheun Jee, Won Kee Yoon, Yoshio Okura, Naoyuki Tanuma, Yoh Matsumoto. (2002) Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. Journal of Neuroimmunology 128:1-2, 49-57
CrossRef843
Catherine M. Dalton, Peter A. Brex, Katherine A. Miszkiel, Simon J. Hickman, David G. MacManus, Gordon T. Plant, Alan J. Thompson, David H. Miller. (2002) Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis. Annals of Neurology 52:1, 47-53
CrossRef844
Eng H. Lo, Xiaoying Wang, M. Louise Cuzner. (2002) Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases. Journal of Neuroscience Research 69:1, 1-9
CrossRef845
Sabine Golde, Siddharthan Chandran, Guy C. Brown, Alastair Compston. (2002) Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. Journal of Neurochemistry 82:2, 269-282
CrossRef846
Yangzhou Du, Cheryl F. Dreyfus. (2002) Oligodendrocytes as providers of growth factors. Journal of Neuroscience Research 68:6, 647-654
CrossRef847
Peter Rieckmann, Mathias Mäurer. (2002) Anti-inflammatory strategies to prevent axonal injury in multiple sclerosis. Current Opinion in Neurology 15:3, 361-370
CrossRef848
Erina M. Schumann, Tania K
CrossRef849
M. N. Degaonkar, M. Khubchandhani, J. K. Dhawan, R. Jayasundar, N. R. Jagannathan. (2002) Sequential proton MRS study of brain metabolite changes monitored during a complete pathological cycle of demyelination and remyelination in a lysophosphatidyl choline (LPC)-induced experimental demyelinating lesion model. NMR in Biomedicine 15:4, 293-300
CrossRef850
L Vaithianathar. (2002) White matter T1 relaxation time histograms and cerebral atrophy in multiple sclerosis. Journal of the Neurological Sciences 197:1-2, 45-50
CrossRef851
D Jeffery. (2002) Early intervention with immunomodulatory agents in the treatment of multiple sclerosis. Journal of the Neurological Sciences 197:1-2, 1-8
CrossRef852
G. Toncev, B. Milicic, S. Toncev, G. Samardzic. (2002) Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction. European Journal of Neurology 9:3, 221-226
CrossRef853
Christopher Lock, Guy Hermans, Rosetta Pedotti, Andrea Brendolan, Eric Schadt, Hideki Garren, Annette Langer-Gould, Samuel Strober, Barbara Cannella, John Allard, Paul Klonowski, Angela Austin, Nagin Lad, Naftali Kaminski, Stephen J. Galli, Jorge R. Oksenberg, Cedric S. Raine, Renu Heller, Lawrence Steinman. (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Medicine 8:5, 500-508
CrossRef854
Christopher Halfpenny, Tracey Benn, Neil Scolding. (2002) Cell transplantation, myelin repair, and multiple sclerosis. The Lancet Neurology 1:1, 31-40
CrossRef855
J. Y. Garbern. (2002) Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. Brain 125:3, 551-561
CrossRef856
J Glass. (2002) Very early activation of m-calpain in peripheral nerve during Wallerian degeneration. Journal of the Neurological Sciences 196:1-2, 9-20
CrossRef857
R Franklin. (2002) Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia. Brain Research Bulletin 57:6, 827-832
CrossRef858
Hui-Hsin Tsai, Robert H. Miller. (2002) Glial cell migration directed by axon guidance cues. Trends in Neurosciences 25:4, 173-175
CrossRef859
Trevor Owens. (2002) Identification of new therapeutic targets for prevention of CNS inflammation. Expert Opinion on Therapeutic Targets 6:2, 203-215
CrossRef860
Isabelle Jean, Chantal Allamargot, Annick Barthelaix-Pouplard, Catherine Fressinaud. (2002) Axonal lesions and PDGF-enhanced remyelination in the rat corpus callosum after lysolecithin demyelination. Neuroreport 13:5, 627-631
CrossRef861
Jonnie Plumb, Stephen McQuaid, Meenakshi Mirakhur, John Kirk. (2002) Abnormal Endothelial Tight Junctions in Active Lesions and Normal-appearing White Matter in Multiple Sclerosis. Brain Pathology 12:2, 154-169
CrossRef862
Alastair Compston, Alasdair Coles. (2002) Multiple sclerosis. The Lancet 359:9313, 1221-1231
CrossRef863
Claudia Schwab, Patrick L. McGeer. (2002) Complement Activated C4d Immunoreactive Oligodendrocytes Delineate Small Cortical Plaques in Multiple Sclerosis. Experimental Neurology 174:1, 81-88
CrossRef864
Lawrence Steinman, Roland Martin, Claude Bernard, Paul Conlon, Jorge R. Oksenberg. (2002) M
ULTIPLE SCLEROSIS : Deeper Understanding of Its Pathogenesis Reveals New Targets for Therapy*. Annual Review of Neuroscience 25:1, 491-505
CrossRef865
Cecilia Rajda, Krisztina Bencsik, László Vécsei L, Jonas Bergquist. (2002) Catecholamine levels in peripheral blood lymphocytes from multiple sclerosis patients. Journal of Neuroimmunology 124:1-2, 93-100
CrossRef866
M. T. Giordana, P. Richiardi, E. Trevisan, A. Boghi, L. Palmucci. (2002) Abnormal ubiquitination of axons in normally myelinated white matter in multiple sclerosis brain. Neuropathology and Applied Neurobiology 28:1, 35-41
CrossRef867
Natalija Popovic, Anna Schubart, Brian D. Goetz, Su-Chun Zhang, Chris Linington, Ian D. Duncan. (2002) Inhibition of autoimmune encephalomyelitis by a tetracycline. Annals of Neurology 51:2, 215-223
CrossRef868
B. Mark Keegan, John H. Noseworthy. (2002) M
ULTIPLE SCLEROSIS . Annual Review of Medicine 53:1, 285-302
CrossRef869
Isabelle M. Medana, Nicholas P. Day, Tran Tinh Hien, Nguyen Thi Hoang Mai, Delia Bethell, Nguyen Hoan Phu, Jeremy Farrar, Margaret M. Esiri, Nicholas J. White, Gareth D. Turner. (2002) Axonal Injury in Cerebral Malaria. The American Journal of Pathology 160:2, 655-666
CrossRef870
Chang, Ansi, Tourtellotte, Wallace W., Rudick, Richard, Trapp, Bruce D., . (2002) Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis. New England Journal of Medicine 346:3, 165-173
Full Text871
Brex, Peter A., Ciccarelli, Olga, O'Riordan, Jonathon I., Sailer, Michael, Thompson, Alan J., Miller, David H., . (2002) A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis. New England Journal of Medicine 346:3, 158-164
Full Text872
C Cid. (2002) Neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients correlates with hypointense lesions on T1 magnetic resonance imaging. Journal of the Neurological Sciences 193:2, 103-109
CrossRef873
Katherine A. Lyseng-Williamson, Greg L. Plosker. (2002) Management of Relapsing-Remitting Multiple Sclerosis. Disease Management and Health Outcomes 10:5, 307-325
CrossRef874
Omar Khan, Rana Zabad, Christina Caon, Marina Zvartau-Hind, Alexandros Tselis, Robert Lisak. (2002) Comparative Assessment of Immunomodulating Therapies for Relapsing-Remitting Multiple Sclerosis. CNS Drugs 16:8, 563-578
CrossRef875
Carl Bjartmar, Jan Battistuta, Nobuo Terada, Erica Dupree, Bruce D. Trapp. (2002) N-acetylaspartate is an axon-specific marker of mature white matter in vivo: A biochemical and immunohistochemical study on the rat optic nerve. Annals of Neurology 51:1, 51-58
CrossRef876
Richard K. Burt, Shimon Slavin, William H. Burns, Alberto M. Marmont. (2002) Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?. International Journal of Hematology 76:S1, 226-247
CrossRef877
Bridget Bagert, Patricia Camplair, Dennis Bourdette. (2002) Cognitive Dysfunction in Multiple Sclerosis. CNS Drugs 16:7, 445-455
CrossRef878
Yulin Ge, Robert I. Grossman, Jayaram K. Udupa, James S. Babb, Lois J. Mannon, Joseph C. McGowan. (2002) Magnetization Transfer Ratio Histogram Analysis of Normal-Appearing Gray Matter and Normal-Appearing White Matter in Multiple Sclerosis. Journal of Computer Assisted Tomography 26:1, 62-68
CrossRef879
Sarlota Mesaros, Jelena Drulovic, Nebojsa Stojsavljevic, Zvonimir Levic. (2002) Značaj magnetske rezonancije u dijagnostici i razumevanju prirode patoloških promena u multiploj sklerozi. Srpski arhiv za celokupno lekarstvo 130:5-6, 226-231
CrossRef880
Antonio Iglesias. (2001) Maintenance and loss of self-tolerance in B cells. Springer Seminars in Immunopathology 23:4, 351-366
CrossRef881
BenoiT Fellay, Michel Chofflon, Catherine Juillard, Anne-Marie Paunier, Theodor Landis, Serge Roth, Marie-Lise Gougeon. (2001) Beneficial effect of co-polymer 1 on cytokine production by CD4 T cells in multiple sclerosis. Immunology 104:4, 383-391
CrossRef882
P Fuhr. (2001) Evoked potentials for evaluation of multiple sclerosis. Clinical Neurophysiology 112:12, 2185-2189
CrossRef883
Min Sheng Wang, Guofu Fang, Deborah G. Culver, Albert A. Davis, Mark M. Rich, Jonathan D. Glass. (2001) The WldS protein protects against axonal degeneration: A model of gene therapy for peripheral neuropathy. Annals of Neurology 50:6, 773-779
CrossRef884
Richard A. Rudick. (2001) Evolving Concepts in the Pathogenesis of Multiple Sclerosis and Their Therapeutic Implications. Journal of Neuro-Ophthalmology 21:4, 279-283
CrossRef885
A. Chaudhuri, P. O. Behan. (2001) Acute cervical hyperextension-hyperflexion injury may precipitate and/or exacerbate symptomatic multiple sclerosis. European Journal of Neurology 8:6, 659-664
CrossRef886
John W. Prineas, Eunice E. Kwon, Eun-Sook Cho, Leroy R. Sharer, Michael H. Barnett, Emilia L. Oleszak, Brad Hoffman, Bryan P. Morgan. (2001) Immunopathology of secondary-progressive multiple sclerosis. Annals of Neurology 50:5, 646-657
CrossRef887
Corinna Trebst, Torben Lykke Sørensen, Pia Kivisäkk, Martha K. Cathcart, Joseph Hesselgesser, Richard Horuk, Finn Sellebjerg, Hans Lassmann, Richard M. Ransohoff. (2001) CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis. The American Journal of Pathology 159:5, 1701-1710
CrossRef888
S. G. M. Edwards, C. Liu, L. D. Blumhardt. (2001) Cognitive correlates of supratentorial atrophy on MRI in multiple sclerosis. Acta Neurologica Scandinavica 104:4, 214-223
CrossRef889
Alastair Wilkins, Siddharthan Chandran, Alastair Compston. (2001) A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons. Glia 36:1, 48-57
CrossRef890
Marjo S Knaap. (2001) Magnetic resonance in childhood white-matter disorders: The 2001 Ronnie Mac Keith Lecture. Developmental Medicine & Child Neurology 43:10, 705-712
CrossRef891
O. A. Khan, A. C. Tselis, J. A. Kamholz, J. Y. Garbern, R. A. Lewis, R. P. Lisak. (2001) Response To Greenstein's letter. European Journal of Neurology 8:5, 505-506
CrossRef892
Isabelle Medana, Marianne A. Martinic, Hartmut Wekerle, Harald Neumann. (2001) Transection of Major Histocompatibility Complex Class I-Induced Neurites by Cytotoxic T Lymphocytes. The American Journal of Pathology 159:3, 809-815
CrossRef893
John W. Peterson, Lars B
CrossRef894
X Lin. (2001) Inflammation and atrophy in multiple sclerosis: MRI associations with disease course. Journal of the Neurological Sciences 189:1-2, 99-104
CrossRef895
Peter Werner, David Pitt, Cedric S. Raine. (2001) Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Annals of Neurology 50:2, 169-180
CrossRef896
Gunther Helms. (2001) Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions. Magnetic Resonance in Medicine 46:2, 256-263
CrossRef897
Massimo Filippi. (2001) Linking structural, metabolic and functional changes in multiple sclerosis. European Journal of Neurology 8:4, 291-297
CrossRef898
J de Seze. (2001) Pupillary disturbances in multiple sclerosis: correlation with MRI findings. Journal of the Neurological Sciences 188:1-2, 37-41
CrossRef899
Yasuhiro Maeda, Mukesh Solanky, Joseph Menonna, John Chapin, Weiping Li, Peter Dowling. (2001) Platelet-derived growth factor-? receptor-positive oligodendroglia are frequent in multiple sclerosis lesions. Annals of Neurology 49:6, 776-785
CrossRef900
Zubair Ahmed, Djordje Gveric, Gareth Pryce, David Baker, John P. Leonard, M. Louise Cuzner. (2001) Myelin/Axonal Pathology in Interleukin-12 Induced Serial Relapses of Experimental Allergic Encephalomyelitis in the Lewis Rat. The American Journal of Pathology 158:6, 2127-2138
CrossRef901
Carl Bjartmar, Bruce D. Trapp. (2001) Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Current Opinion in Neurology 14:3, 271-278
CrossRef902
Paul M. Matthews, Douglas L. Arnold. (2001) Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution. Current Opinion in Neurology 14:3, 279-287
CrossRef903
Claudia Lucchinetti, Wolfgang Brück, John Noseworthy. (2001) Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Current Opinion in Neurology 14:3, 259-269
CrossRef904
Qingdi Q. Li, David R. Burt, Christopher T. Bever. (2001) Glatiramer acetate inhibition of tumor necrosis factor-α-induced RANTES expression and release from U-251 MG human astrocytic cells. Journal of Neurochemistry 77:5, 1208-1217
CrossRef905
Peter M. Mathisen, Julie A. Kawczak, Min Yu, Justin M. Johnson, Vincent K. Tuohy. (2001) Differential DM20 mRNA expression distinguishes two distinct patterns of spontaneous recovery from murine autoimmune encephalomyelitis. Journal of Neuroscience Research 64:5, 542-551
CrossRef906
Mats Soderstrom. (2001) Optic neuritis and multiple sclerosis. Acta Ophthalmologica Scandinavica 79:3, 223-227
CrossRef907
Andreas Bitsch, Tanja Kuhlmann, Christine Stadelmann, Hans Lassmann, Claudia Lucchinetti, Wolfgang Br
CrossRef908
J Maldjian. (2001) Future applications of DWI in MS. Journal of the Neurological Sciences 186, S55-S57
CrossRef909
Roland Martin, Bruno Gran, Yingdong Zhao, Silva Markovic-Plese, Bibiana Bielekova, Adriana Marques, Myong-Hee Sung, Bernhard Hemmer, Richard Simon, Henry F McFarland, Clemencia Pinilla. (2001) Molecular Mimicry and Antigen-Specific T Cell Responses in Multiple Sclerosis and Chronic CNS Lyme Disease. Journal of Autoimmunity 16:3, 187-192
CrossRef910
Giancarlo Comi, Massimo Filippi, Frederik Barkhof, Luca Durelli, Gilles Edan, Oscar Fernández, Hans-Peter Hartung, Pierrette Seeldrayers, Per Soelberg Sørensen, Marco Rovaris, Vittorio Martinelli, Otto R Hommes. (2001) Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. The Lancet 357:9268, 1576-1582
CrossRef911
Silva Markovic-Plese, Henry F. McFarland. (2001) Immunopathogenesis of the multiple sclerosis lesion. Current Neurology and Neuroscience Reports 1:3, 257-262
CrossRef912
A Øren. (2001) Apoptosis in neurones exposed to cerebrospinal fluid from patients with multiple sclerosis or acute polyradiculoneuropathy. Journal of the Neurological Sciences 186:1-2, 31-36
CrossRef913
Jack P Antel, Trevor Owens. 2001. Neuroimmunology. .
CrossRef914
Kenneth J. Smith, Raju Kapoor, Susan M. Hall, Meirion Davies. (2001) Electrically active axons degenerate when exposed to nitric oxide. Annals of Neurology 49:4, 470-476
CrossRef915
Paul D. Drew, Janet A. Chavis. (2001) The cyclopentone prostaglandin 15-deoxy-Δ12,14 prostaglandin J2 represses nitric oxide, TNF-α, and IL-12 production by microglial cells. Journal of Neuroimmunology 115:1-2, 28-35
CrossRef916
Rohit Bakshi, Ralph H. B. Benedict, Robert A. Bermel, Lawrence Jacobs. (2001) Regional Brain Atrophy Is Associated With Physical Disability in Multiple Sclerosis: Semiquantitative Magnetic Resonance Imaging and Relationship to Clinical Findings. Journal of Neuroimaging 11:2, 129-136
CrossRef917
Rudolf Martini. (2001) The effect of myelinating Schwann cells on axons. Muscle & Nerve 24:4, 456-466
CrossRef918
T. Polak, G. Schlaf, U. Schöll, C. Krome-Cesar, M. Mäder, K. Felgenhauer, F. Weber. (2001) Characterization of the human T cell response against the neuronal protein synapsin in patients with multiple sclerosis. Journal of Neuroimmunology 115:1-2, 176-181
CrossRef919
OLAF DAMMANN, HENRIK HAGBERG, AND, ALAN LEVITON. (2001) Is Periventricular Leukomalacia an Axonopathy as Well as an Oligopathy?. Pediatric Research 49:4, 453-457
CrossRef920
Manabu Onuki, Margaret M. Ayers, Claude C.A. Bernard, Jacqueline M. Orian. (2001) Axonal degeneration is an early pathological feature in autoimmune-mediated demyelination in mice. Microscopy Research and Technique 52:6, 731-739
CrossRef921
R Bakshi. (2001) Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients. Journal of the Neurological Sciences 185:1, 19-26
CrossRef922
Dean M Wingerchuk, Claudia F Lucchinetti, John H Noseworthy. (2001) Multiple Sclerosis: Current Pathophysiological Concepts. Laboratory Investigation 81:3, 263-281
CrossRef923
Hans Lassmann, Wolfgang Brück, Claudia Lucchinetti. (2001) Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends in Molecular Medicine 7:3, 115-121
CrossRef924
G Mancardi. (2001) Demyelination and axonal damage in a non-human primate model of multiple sclerosis. Journal of the Neurological Sciences 184:1, 41-49
CrossRef925
Min-Sheng Wang, Yue Wu, Deborah G. Culver, Jonathan D. Glass. (2001) The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine Neuropathy. Neurobiology of Disease 8:1, 155-161
CrossRef926
(2001) Interferon Beta-1a during a First Demyelinating Event. New England Journal of Medicine 344:3, 229-230
Full Text927
Anne I. Boullerne, Liljana Nedelkoska, Joyce A. Benjamins. (2001) Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes. Journal of Neuroscience Research 63:2, 124-135
CrossRef928
Jack H. Simon. (2001) Brain and Spinal Cord Atrophy in Multiple Sclerosis. CNS Drugs 15:6, 427-436
CrossRef929
I Simone. (2001) Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study. Journal of the Neurological Sciences 182:2, 143-150
CrossRef930
M. Sailer, N. A. Losseff, L. Wang, M. L. Gawne-Cain, A. J. Thompson, D. H. Miller. (2001) T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow-up study. European Journal of Neurology 8:1, 37-42
CrossRef931
Douglas S. Goodin. (2001) Interferon-?? Therapy in Multiple Sclerosis. Drugs 61:12, 1693-1703
CrossRef932
Jill S. Fischer, Roger L. Priore, Lawrence D. Jacobs, Diane L. Cookfair, Richard A. Rudick, Robert M. Herndon, John R. Richert, Andres M. Salazar, Donald E. Goodkin, Carl V. Granger, Jack H. Simon, Jordan H. Grafman, Muriel D. Lezak, Kathleen M. O'Reilly Hovey, Katherine Kawczak Perkins, Danielle Barilla-Clark, Mark Schacter, David W. Shucard, Anna L. Davidson, Karl E. Wende, Dennis N. Bourdette, Mariska F. Kooijmans-Coutinho, . (2000) Neuropsychological effects of interferon ?-1a in relapsing multiple sclerosis. Annals of Neurology 48:6, 885-892
CrossRef933
O Gonen. (2000) The accuracy of whole brain N-acetylaspartate quantification. Magnetic Resonance Imaging 18:10, 1255-1258
CrossRef934
Carl Bjartmar, Grahame Kidd, Sverre M
CrossRef935
Ewa Carrier, Ann Traynor, Richard K. Burt. (2000) Pros and cons of hematopoietic stem cell transplant for autoimmune disease. Current Opinion in Organ Transplantation 5:4, 343-351
CrossRef936
Confavreux, Christian, Vukusic, Sandra, Moreau, Thibault, Adeleine, Patrice, . (2000) Relapses and Progression of Disability in Multiple Sclerosis. New England Journal of Medicine 343:20, 1430-1438
Full Text937
Paul D Drew, Janet A Chavis. (2000) Female sex steroids: effects upon microglial cell activation. Journal of Neuroimmunology 111:1-2, 77-85
CrossRef938
Konstance K. Knox, Joseph H. Brewer, James M. Henry, Daniel J. Harrington, Donald R. Carrigan. (2000) Human Herpesvirus 6 and Multiple Sclerosis: Systemic Active Infections in Patients with Early Disease. Clinical Infectious Diseases 31:4, 894-903
CrossRef939
Sith Sathornsumetee, Dorian B. McGavern, Daren R. Ure, Moses Rodriguez. (2000) Quantitative Ultrastructural Analysis of a Single Spinal Cord Demyelinated Lesion Predicts Total Lesion Load, Axonal Loss, and Neurological Dysfunction in a Murine Model of Multiple Sclerosis. The American Journal of Pathology 157:4, 1365-1376
CrossRef940
Noseworthy, John H., Lucchinetti, Claudia, Rodriguez, Moses, Weinshenker, Brian G., . (2000) Multiple Sclerosis. New England Journal of Medicine 343:13, 938-952
Full Text941
V Stevenson. (2000) Variations in T1 and T2 relaxation times of normal appearing white matter and lesions in multiple sclerosis. Journal of the Neurological Sciences 178:2, 81-87
CrossRef942
J. Correale, W. Gilmore, S. Li, J. Walsh, M.M. Bassani, Brett Lund, M. Arias, L.P. Weiner. (2000) Resistance to glucocorticoid-induced apoptosis in PLP peptide-specific T cell clones from patients with progressive MS. Journal of Neuroimmunology 109:2, 197-210
CrossRef943
D Jeffery. (2000) Relationship between disease activity and dose–response relationships with beta interferon therapies in the treatment of multiple sclerosis. Journal of the Neurological Sciences 178:1, 2-9
CrossRef944
Antje Niehaus, Jian Shi, Martina Grzenkowski, Marianne Diers-Fenger, Juan Archelos, Hans-Peter Hartung, Klaus Toyka, Wolfgang Br
CrossRef945
F Lu. (2000) Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis. Journal of the Neurological Sciences 177:2, 95-103
CrossRef946
Ligong Cao, Deming Sun, Tony Cruz, Mario A. Moscarello, Samuel K. Ludwin, John N. Whitaker. (2000) Inhibition of experimental allergic encephalomyelitis in the Lewis rat by paclitaxel. Journal of Neuroimmunology 108:1-2, 103-111
CrossRef947
Lawrence Jacobs, Richard Rudick, Jack Simon. (2000) Extended observations on MS patients treated with IM interferon-β1a (Avonex™): implications for modern MS trials and therapeutics. Journal of Neuroimmunology 107:2, 167-173
CrossRef948
Juan J. Archelos, Hans-Peter Hartung. (2000) Pathogenetic role of autoantibodies in neurological diseases. Trends in Neurosciences 23:7, 317-327
CrossRef949
Reinhard Hohlfeld, Martin Kerschensteiner, Christine Stadelmann, Hans Lassmann, Hartmut Wekerle. (2000) The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Journal of Neuroimmunology 107:2, 161-166
CrossRef950
Gianluigi Mancardi, Bert A ‘t Hart, Elisabetta Capello, Herbert P.M Brok, Avraham Ben-Nun, Luca Roccatagliata, Debora Giunti, Paola Gazzola, Mariella Dono, Nicole Kerlero de Rosbo, Monica Colombo, Antonio Uccelli. (2000) Restricted immune responses lead to CNS demyelination and axonal damage. Journal of Neuroimmunology 107:2, 178-183
CrossRef951
Barbara Kornek, Maria K. Storch, Robert Weissert, Erik Wallstroem, Andreas Stefferl, Tomas Olsson, Christopher Linington, Manfred Schmidbauer, Hans Lassmann. (2000) Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis. The American Journal of Pathology 157:1, 267-276
CrossRef952
M. Chofflon. (2000) Recombinant human interferon beta in relapsing-remitting multiple sclerosis: a review of the major clinical trials. European Journal of Neurology 7:4, 369-380
CrossRef953
Ulrike Gimsa, Susanne VA. Peter, Kathrin Lehmann, Ingo Bechmann, Robert Nitsch. (2000) Axonal Damage Induced by Invading T Cells in Organotypic Central Nervous System Tissue in vitro: Involvement of Microglial Cells. Brain Pathology 10:3, 365-377
CrossRef954
Giancarlo Comi. (2000) Why treat early multiple sclerosis patients?. Current Opinion in Neurology 13:3, 235-240
CrossRef955
Juan J. Archelos, Maria K. Storch, Hans-Peter Hartung. (2000) The role of B cells and autoantibodies in multiple sclerosis. Annals of Neurology 47:6, 694-706
CrossRef956
Samuel K. Ludwin. (2000) Understanding multiple sclerosis: Lessons from pathology. Annals of Neurology 47:6, 691-693
CrossRef957
S Leary. (2000) A 1H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis. Magnetic Resonance Imaging 18:4, 455-459
CrossRef958
M. Lee, H. Reddy, H. Johansen-Berg, S. Pendlebury, M. Jenkinson, S. Smith, J. Palace, P. M. Matthews. (2000) The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis. Annals of Neurology 47:5, 606-613
CrossRef959
Richard M Ransohoff, Kevin B Bacon. (2000) Chemokine receptor antagonism as a new therapy for multiple sclerosis. Expert Opinion on Investigational Drugs 9:5, 1079-1097
CrossRef960
Douglas S Goodin. (2000) Therapeutic developments in multiple sclerosis. Expert Opinion on Investigational Drugs 9:4, 655-670
CrossRef961
A. Alcázar, I. Regidor, J. Masjuan, M. Salinas, J.C. Álvarez-Cermeño. (2000) Axonal damage induced by cerebrospinal fluid from patients with relapsing-remitting multiple sclerosis. Journal of Neuroimmunology 104:1, 58-67
CrossRef962
A Paolillo. (2000) Brain atrophy in relapsing-remitting multiple sclerosis: relationship with 'black holes', disease duration and clinical disability. Journal of the Neurological Sciences 174:2, 85-91
CrossRef963
Bianca Weinstock-Guttman, Lawrence D. Jacobs. (2000) What is New in the Treatment of Multiple Sclerosis?. Drugs 59:3, 401-410
CrossRef964
David N Irani, Douglas A Kerr. (2000) 14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis. The Lancet 355:9207, 901
CrossRef965
Nikos Evangelou, Margaret M. Esiri, Steve Smith, Jackie Palace, Paul M. Matthews. (2000) Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Annals of Neurology 47:3, 391-395
CrossRef966
Andreas Bitsch, Tanja Kuhlmann, Christiane Da Costa, Stephanie Bunkowski, Thomas Polak, Wolfgang Br
CrossRef967
B Sharrack. (2000) The effect of oral and intravenous methylprednisolone treatment on subsequent relapse rate in multiple sclerosis. Journal of the Neurological Sciences 173:1, 73-77
CrossRef968
J McGowan. (2000) Technical issues for MRI examination of the posterior fossa. Journal of the Neurological Sciences 172, S40-S42
CrossRef969
G Comi. (2000) Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques. Journal of the Neurological Sciences 172, S63-S66
CrossRef970
R Grossman. (2000) The contribution of magnetic resonance imaging in the differential diagnosis of the damage of the cerebral hemispheres. Journal of the Neurological Sciences 172, S57-S62
CrossRef971
Brian G Weinshenker. (2000) Progressive forms of MS: classification streamlined or consensus overturned?. The Lancet 355:9199, 162-163
CrossRef972
P. van der Valk, C. J. A. De Groot. (2000) Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS. Neuropathology and Applied Neurobiology 26:1, 2-10
CrossRef973
Robert Weinstein. (2000) Therapeutic apheresis in neurological disorders. Journal of Clinical Apheresis 15:1-2, 74-128
CrossRef974
G Iannucci. (1999) Correlations between clinical and MRI involvement in multiple sclerosis: assessment using T1, T2 and MT histograms. Journal of the Neurological Sciences 171:2, 121-129
CrossRef975
M Inglese. (1999) Quantitative brain volumetric analysis from patients with multiple sclerosis: a follow-up study. Journal of the Neurological Sciences 171:1, 8-10
CrossRef976
George H Kraft. (1999) Rehabilitation still the only way to improve function in multiple sclerosis. The Lancet 354:9195, 2016-2017
CrossRef977
Dirk H.-H. Neuberg, Sara Sancho, Ueli Suter. (1999) Altered molecular architecture of peripheral nerves in mice lacking the peripheral myelin protein 22 or connexin32. Journal of Neuroscience Research 58:5, 612-623
CrossRef978
Francois A. Bethoux, Jeffrey A. Cohen. (1999) Diagnosis and Treatment of Multiple Sclerosis. Current Opinion in Orthopedics 10:6, 492-497
CrossRef979
Marie-Christine Birling, Steven Tait, Rebecca J. Hardy, Peter J. Brophy. (1999) A Novel Rat Tetraspan Protein in Cells of the Oligodendrocyte Lineage. Journal of Neurochemistry 73:6, 2600-2608
CrossRef980
Ganter, Prince, Esiri. (1999) Spinal cord axonal loss in multiple sclerosis: a post-mortem study. Neuropathology and Applied Neurobiology 25:6, 459-467
CrossRef981
Giti Garthwaite, David A. Goodwin, John Garthwaite. (1999) Nitric oxide stimulates cGMP formation in rat optic nerve axons, providing a specific marker of axon viability. European Journal of Neuroscience 11:12, 4367-4372
CrossRef982
E Silber. (1999) Axonal degeneration in the pathogenesis of multiple sclerosis. Journal of the Neurological Sciences 170:1, 11-18
CrossRef983
Dorian B. McGavern, Paul D. Murray, Moses Rodriguez. (1999) Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury. Journal of Neuroscience Research 58:4, 492-504
CrossRef984
Takahiro Gotow, Jean F. Leterrier, Yoshiyuki Ohsawa, Tsuyoshi Watanabe, Kyoko Isahara, Riichi Shibata, Kazuhiro Ikenaka, Yasuo Uchiyama. (1999) Abnormal expression of neurofilament proteins in dysmyelinating axons located in the central nervous system of jimpy mutant mice. European Journal of Neuroscience 11:11, 3893-3903
CrossRef985
Fredrik Piehl, Cecilia Lundberg, Mohsen Khademi, Anders Bucht, Ingrid Dahlman, Johnny C. Lorentzen, Tomas Olsson. (1999) Non-MHC gene regulation of nerve root injury induced spinal cord inflammation and neuron death. Journal of Neuroimmunology 101:1, 87-97
CrossRef986
J. H. T. M. Van Waesberghe, W. Kamphorst, C. J. A. De Groot, M. A. A. Van Walderveen, J. A. Castelijns, R. Ravid, G. J. Lycklama
CrossRef987
Lawrence Steinman. (1999) Assessment of Animal Models for MS and Demyelinating Disease in the Design of Rational Therapy. Neuron 24:3, 511-514
CrossRef988
R. KAPOOR, M. DAVIES, K. J. SMITH. (1999) Temporary Axonal Conduction Block and Axonal Loss in Inflammatory Neurological Disease: A Potential Role for Nitric Oxide?. Annals of the New York Academy of Sciences 893:1 OXIDATIVE/ENE, 304-308
CrossRef989
Barbara Kornek, Hans Lassmann. (1999) Axonal Pathology in Multiple Sclerosis. A Historical Note. Brain Pathology 9:4, 651-656
CrossRef990
Alasdair J. Coles, Mark G. Wing, Paul Molyneux, Andrea Paolillo, Charlie M. Davie, Geoff Hale, David Miller, Hermann Waldmann, Alastair Compston. (1999) Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis. Annals of Neurology 46:3, 296-304
CrossRef991
J Fawcett. (1999) The glial scar and central nervous system repair. Brain Research Bulletin 49:6, 377-391
CrossRef992
Marinos C. Dalakas. (1999) Advances in chronic inflammatory demyelinating polyneuropathy: disease variants and inflammatory response mediators and modifiers. Current Opinion in Neurology 12:4, 403-409
CrossRef993
Richard A Rudick, Andrew Goodman, Robert M Herndon, Hillel S Panitch. (1999) Selecting relapsing remitting multiple sclerosis patients for treatment: the case for early treatment. Journal of Neuroimmunology 98:1, 22-28
CrossRef994
Jack H Simon. (1999) From enhancing lesions to brain atrophy in relapsing MS. Journal of Neuroimmunology 98:1, 7-15
CrossRef995
Gennadij Raivich, Marion Bohatschek, Christian U.A. Kloss, Alexander Werner, Leonard L. Jones, Georg W. Kreutzberg. (1999) Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Research Reviews 30:1, 77-105
CrossRef996
D.L Arnold. (1999) Magnetic resonance spectroscopy: imaging axonal damage in MS. Journal of Neuroimmunology 98:1, 2-6
CrossRef997
Marianne A. A. Van Walderveen, Frederik Barkhof, Petra J. W. Pouwels, Ronald A. Van Schijndel, Chris H. Polman, Jonas A. Castelijns. (1999) Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Annals of Neurology 46:1, 79-87
CrossRef998
Olga Ciccarelli, Elisabetta Giugni, Andrea Paolillo, Caterina Mainero, Claudio Gasperini, Stefano Bastianello, Carlo Pozzilli. (1999) Magnetic resonance outcome of new enhancing lesions in patients with relapsing-remitting multiple sclerosis. European Journal of Neurology 6:4, 455-459
CrossRef999
Bruce D Trapp, Lars Bö, Sverre Mörk, Ansi Chang. (1999) Pathogenesis of tissue injury in MS lesions. Journal of Neuroimmunology 98:1, 49-56
CrossRef1000
William F Hickey. (1999) The pathology of multiple sclerosis: a historical perspective1Supported in part by award NS 27321.1. Journal of Neuroimmunology 98:1, 37-44
CrossRef1001
Richard M Ransohoff. (1999) Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines. Journal of Neuroimmunology 98:1, 57-68
CrossRef1002
P Brex. (1999) Proton MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis. Journal of the Neurological Sciences 166:1, 16-22
CrossRef1003
Bruce D. Trapp, Richard Ransohoff, Richard Rudick. (1999) Axonal pathology in multiple sclerosis: relationship to neurologic disability. Current Opinion in Neurology 12:3, 295-302
CrossRef1004
Edgar Meinl. (1999) Concepts of viral pathogenesis of multiple sclerosis. Current Opinion in Neurology 12:3, 303-307
CrossRef1005
Bibiana Bielekova, Roland Martin. (1999) Multiple sclerosis: Immunotherapy. Current Treatment Options in Neurology 1:3, 201-219
CrossRef1006
N. D. Jeffery, A. J. Crang, M. T. O'Leary, S. J. Hodge, W. F. Blakemore. (1999) Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord. European Journal of Neuroscience 11:5, 1508-1514
CrossRef1007
P Dastidar. (1999) Volumes of brain atrophy and plaques correlated with neurological disability in secondary progressive multiple sclerosis. Journal of the Neurological Sciences 165:1, 36-42
CrossRef1008
B Zhu. (1999) Axonal cytoskeleton changes in experimental optic neuritis. Brain Research 824:2, 204-217
CrossRef1009
(1999) The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis & Rheumatism 42:4, 599-608
CrossRef1010
Henry C. Powell, Robert S. Garrett, Francesca M. Brett, Chi-Shuin Chiang, Emily Chen, Eliezer Masliah, Iain L. Campbell. (1999) Response of Glia, Mast Cells and the Blood Brain Barrier, in Transgenic Mice Expressing Interleukin-3 in Astrocytes, an Experimental Model for CNS Demyelination. Brain Pathology 9:2, 219-235
CrossRef1011
Torben L. Sørensen, Marie Tani, Jakob Jensen, Virginia Pierce, Claudia Lucchinetti, Virginia A. Folcik, Shixin Qin, Jim Rottman, Finn Sellebjerg, Robert M. Strieter, Jette L. Frederiksen, Richard M. Ransohoff. (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. Journal of Clinical Investigation 103:6, 807-815
CrossRef1012
Dana L. Madison, Winfried H. Krueger, David Cheng, Bruce D. Trapp, S. E. Pfeiffer. (1999) SNARE Complex Proteins, Including the Cognate Pair VAMP-2and Syntaxin-4, Are Expressed in Cultured Oligodendrocytes. Journal of Neurochemistry 72:3, 988-998
CrossRef1013
F. González-Scarano, Gordon Baltuch. (1999) MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES. Annual Review of Neuroscience 22:1, 219-240
CrossRef1014
A. I. Boullerne, L. Nedelkoska, J. A. Benjamins. (1999) Synergism of Nitric Oxide and Iron in Killing the Transformed Murine Oligodendrocyte Cell Line N20.1. Journal of Neurochemistry 72:3, 1050-1060
CrossRef1015
Tomas Bergström. (1999) Herpesviruses—a rationale for antiviral treatment in multiple sclerosis. Antiviral Research 41:1, 1-19
CrossRef1016
Rachel H. Woodruff, Robin J.M. Franklin. (1999) Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: A comparative study. Glia 25:3, 216-228
CrossRef1017
Kenneth J. Smith, Raju Kapoor, Paul A. Felts. (1999) Demyelination: The Role of Reactive Oxygen and Nitrogen Species. Brain Pathology 9:1, 69-92
CrossRef1018
Steven Scherer. (1999) Axonal pathology in demyelinating diseases. Annals of Neurology 45:1, 6-7
CrossRef1019
Brian G. Weinshenker. (1999) Therapeutic plasma exchange for acute inflammatory demyelinating syndromes of the central nervous system. Journal of Clinical Apheresis 14:3, 144-148
CrossRef1020
B. Tayyebeh Sadatipour, Judith M. Greer, Michael P. Pender. (1998) Increased circulating antiganglioside antibodies in primary and secondary progressive multiple sclerosis. Annals of Neurology 44:6, 980-983
CrossRef1021
McKay, Blakemore, Franklin. (1998) Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes. Neuropathology and Applied Neurobiology 24:6, 498-506
CrossRef1022
Julie A. Kawczak, Peter M. Mathisen, Judith A. Drazba, Babette Fuss, Wendy B. Macklin, Vincent K. Tuohy. (1998) Digitized image analysis reveals diffuse abnormalities in normal-appearing white matter during acute experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 54:3, 364-372
CrossRef1023
Oded Gonen, A. Kasi Viswanathan, Isabelle Catalaa, James Babb, Jayaram Udupa, Robert I. Grossman. (1998) Total brain N-acetylaspartate concentration in normal, age-grouped females: Quantitation with non-echo proton NMR spectroscopy. Magnetic Resonance in Medicine 40:5, 684-689
CrossRef1024
Donald E Goodkin. (1998) Interferon β therapy for multiple sclerosis. The Lancet 352:9139, 1486-1487
CrossRef1025
Jack H. Simon, Lawrence D. Jacobs, Marilyn Campion. (1998) Reply. Annals of Neurology 44:3, 424-425
CrossRef1026
Rudy Castellani. (1998) Multiple System Atrophy. The American Journal of Pathology 153:3, 671-676
CrossRef1027
Lori L. Billinghurst, Rosanne M. Taylor, Evan Y. Snyder. (1998) Remyelination: Cellular and gene therapy. Seminars in Pediatric Neurology 5:3, 211-228
CrossRef1028
Neil Scolding, Robin Franklin. (1998) Axon loss in multiple sclerosis. The Lancet 352:9125, 340-341
CrossRef1029
Philippe Monteyne, Jean-Fran??ois Bureau, Michel Brahic. (1998) Viruses and multiple sclerosis. Current Opinion in Neurology287-291
CrossRef1030
Michel Clanet, Isabelle Berry. (1998) Magnetic resonance imaging in multiple sclerosis. Current Opinion in Neurology299-303
CrossRef1031
Whitaker, John N., . (1998) Effects of Pregnancy and Delivery on Disease Activity in Multiple Sclerosis. New England Journal of Medicine 339:5, 339-340
Full Text1032
Waxman, Stephen G., . (1998) Demyelinating Diseases — New Pathological Insights, New Therapeutic Targets. New England Journal of Medicine 338:5, 323-325
Full Text1033
M. Filippi. (1998) Contribution of magnetic resonance imaging techniques in understanding cognitive impairment in multiple sclerosis. The Italian Journal of Neurological Sciences 19:S6, S399-S402
CrossRef1034
Linda L Johnson, Richard Dyer, Donald J Hupe. (1998) Matrix metalloproteinases. Current Opinion in Chemical Biology 2:4, 466-471
CrossRef
