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Original Article

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation

Richard D. Hurt, M.D., David P.L. Sachs, M.D., Elbert D. Glover, Ph.D., Kenneth P. Offord, M.S., J. Andrew Johnston, Pharm.D., Lowell C. Dale, M.D., Moise A. Khayrallah, Ph.D., Darrell R. Schroeder, M.S., Penny N. Glover, M.Ed., C. Rollynn Sullivan, M.D., Ivana T. Croghan, Ph.D., and Pamela M. Sullivan, M.D.

N Engl J Med 1997; 337:1195-1202October 23, 1997

Abstract

Background and Methods

Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double-blind, placebo-controlled trial of a sustained-release form of bupropion for smoking cessation. We excluded smokers with current depression, but not those with a history of major depression. The 615 subjects were randomly assigned to receive placebo or bupropion at a dose of 100, 150, or 300 mg per day for seven weeks. The target quitting date (or “target quit date”) was one week after the beginning of treatment. Brief counseling was provided at base line, weekly during treatment, and at 8, 12, 26, and 52 weeks. Self-reported abstinence was confirmed by a carbon monoxide concentration in expired air of 10 ppm or less.

Results

At the end of seven weeks of treatment, the rates of smoking cessation as confirmed by carbon monoxide measurements were 19.0 percent in the placebo group, 28.8 percent in the 100-mg group, 38.6 percent in the 150-mg group, and 44.2 percent in the 300-mg group (P<0.001). At one year the respective rates were 12.4 percent, 19.6 percent, 22.9 percent, and 23.1 percent. The rates for the 150-mg group (P = 0.02) and the 300-mg group (P = 0.01) — but not the 100-mg group (P = 0.09) — were significantly better than those for the placebo group. Among the subjects who were continuously abstinent through the end of treatment, the mean absolute weight gain was inversely associated with the dose (a gain of 2.9 kg in the placebo group, 2.3 kg in 100-mg and 150-mg groups, and 1.5 kg in the 300-mg group; P = 0.02). No effects of treatment were observed on depression scores as measured serially by the Beck Depression Inventory. Thirty-seven subjects stopped treatment prematurely because of adverse events; the frequency was similar among all groups.

Conclusions

A sustained-release form of bupropion was effective for smoking cessation and was accompanied by reduced weight gain and minimal side effects. Many participants in all groups were smoking at one year.

Media in This Article

Figure 3Mean Change from Base Line in the Withdrawal Score.
Figure 1Rates of Confirmed Continuous Abstinence from the Target Quitting Date through the End of Treatment.
Article

Pharmacologic treatments such as nicotine-replacement therapy have been shown to help smokers stop smoking. Using a medication that does not contain nicotine, such as an antidepressant, has intrigued investigators for several reasons. Smokers are more likely to have a history of major depression than nonsmokers,1,2 and nicotine may act as an antidepressant in some smokers.3,4 The development of a depressed affect or depression after smoking cessation may lead to relapse.5-7

Results of clinical trials of antidepressant therapy for smoking cessation have been mixed. The initial experience with doxepin was promising; however, no large trials have been reported.8 The results of trials of fluoxetine have not been published. A serotonin-uptake inhibitor had no effect on smoking rates in heavy smokers.9 An immediate-release form of bupropion (300 mg per day for 12 weeks) showed efficacy in two double-blind, placebo-controlled trials, one with 42 male smokers and the other with 190 smokers.10 On the basis of these results, we evaluated the efficacy and safety of a sustained-release form of bupropion (Zyban, Glaxo Wellcome) as an aid to smoking cessation. This form of bupropion was recently approved by the Food and Drug Administration as a prescription drug for the indication of smoking cessation.

Methods

Subjects

This randomized, double-blind, placebo-controlled, dose–response study was performed at three sites (Mayo Clinic, Rochester, Minn.; the Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, Calif.; and West Virginia University, Morgantown) and approved by each center's institutional review board. Recruitment was conducted through advertisements and press releases. A total of 742 volunteers who were interested in stopping smoking were evaluated, of whom 615 met the study criteria and underwent randomization. After an initial screening interview conducted by telephone, subjects attended an informational meeting at which the study was explained, questionnaires completed, and written informed consent provided.

The subjects were eligible for inclusion if they were at least 18 years of age, had smoked an average of 15 cigarettes or more per day for the past year, were motivated to stop smoking, and were in generally good health. Only one smoker per household was allowed in the study. Exclusion criteria included the presence or a family history of a seizure disorder, a history of severe head trauma, predisposition to seizures (such as a history of brain tumor or stroke), a history or current diagnosis of anorexia nervosa or bulimia, the presence of an unstable medical or psychiatric condition, pregnancy, lactation, a history of dependence on alcohol or a non-nicotine substance within the past year, current use of psychotropic medications, previous use of bupropion, current use of tobacco products other than cigarettes, and current use of any nicotine-replacement therapy, fluoxetine, clonidine, buspirone, or doxepin. Subjects with current depression as assessed by the physician were also excluded. Those with a history of major depression as assessed by a structured clinical interview were not excluded.11

At the base-line visit subjects were randomly assigned to receive either a sustained-release form of bupropion at a dose of 100 mg per day (50 mg twice a day), 150 mg per day (150 mg each morning and placebo each evening), or 300 mg per day (150 mg per day for three days, followed by 150 mg twice a day) or placebo (twice a day). All the tablets were identical in appearance. Subjects set a target quitting date (or “target quit date”) after one week of medication (usually the eighth day). They returned weekly during the 7-week treatment phase, then at 8, 12, 26, and 52 weeks for follow-up. The subjects were telephoned 3 days after the target quitting date and at 4, 5, 7, 8, 9, 10, and 11 months. At the base-line physical examination, each subject received a brief, personalized message to stop smoking from the physician and self-help material based on the National Cancer Institute program.12 In this program, which has been validated as an effective intervention for smoking cessation, the physician asks each patient whether he or she smokes, advises all smokers to stop smoking, helps the patient set a quitting date, and arranges a follow-up visit.

Subjects underwent chest roentgenography, laboratory testing, electrocardiography, and physical examination. We obtained data on smoking history, asked subjects to keep a daily diary to record smoking rates and symptoms of nicotine withdrawal,13 and administered several questionnaires.14-16 The eight-item Fagerström Tolerance Questionnaire is a widely used measure of nicotine dependence with a score ranging from 0 to 11; a score of 6 or greater indicates higher levels of dependence.17 The Beck Depression Inventory is a 21-item questionnaire completed by the subject that assesses the severity of depressive symptoms.15 Total scores range from 0 to 63, with scores of 9 or below considered to be within the normal range. Scores of 10 to 18 indicate mild-to-moderate depression, scores of 19 to 29 indicate moderate-to-severe depression, and scores of 30 or higher indicate severe depression. Each week we collected the subjects' daily diaries and recorded concomitant medication use, adverse events, vital signs, and the carbon monoxide content of expired air. Self-reported abstinence was considered validated by a carbon monoxide level in expired air of 10 ppm or below. Brief individual counseling (approximately 10 to 15 minutes) was provided by a study assistant at each visit.

Statistical Analysis

The sample size was based on the ability to detect a difference between active treatment and placebo at the end of treatment, given a projected abstinence rate of 40 percent in the bupropion groups and 24 percent in the placebo group. Approximately 130 subjects were needed for each treatment group, in order to have a two-sided alpha level of 0.05 and a power of 0.80 to detect such a difference. To ensure an adequate sample, 150 subjects were enrolled in each treatment group.

The base-line characteristics of the four groups of subjects were compared by analysis of variance for continuous variables and chi-square analysis for categorical variables. The efficacy of smoking cessation was evaluated with the use of weekly point-prevalence abstinence rates and rates of continuous abstinence. For the point-prevalence rates, subjects were classified as abstinent if they reported not smoking during the previous seven days and this report was confirmed by an expired carbon monoxide value of 10 ppm or less. To be classified as continuously abstinent, the subjects had to be confirmed as not smoking on the basis of carbon monoxide measurement at each visit. In all cases, an intention-to-treat analysis was performed. Subjects who missed a follow-up visit were considered to be smoking. Randomization of subjects was stratified according to site to ensure that similar numbers of subjects were assigned to each group at each site. However, to verify the assumption that the effect of treatment was not dependent on the study site, the efficacy of smoking cessation was first evaluated with logistic-regression modeling. In these models, the dependent variable was smoking status, as confirmed by carbon monoxide measurement, and the independent variables were dose (placebo vs. 100 mg vs. 150 mg vs. 300 mg of bupropion) and study site (California vs. Minnesota vs. West Virginia). We included an interaction term to assess whether the effect of dose was dependent on the study site. After verifying that the effect of treatment was not dependent on the study site, we performed a logistic-regression analysis to assess differences between groups including site as a covariate. The comparisons of placebo with 100 mg of bupropion, placebo with 150 mg of bupropion, and placebo with 300 mg of bupropion were identified a priori to be of specific interest.

Body weight was analyzed among subjects who were continuously abstinent during the treatment phase. The absolute change in weight from base line was calculated weekly from the start of medication through the end of treatment. The effect of dose was evaluated with a two-factor repeated-measures analysis of variance model, with dose as an independent continuous cross-classification factor and time as the repeated factor. We included an interaction term to assess whether the effect of dose was consistent over time. Linear regression and pairwise dose comparisons were used to supplement these analyses.

Withdrawal symptoms were assessed daily with a composite withdrawal score computed as the mean of the nine items included in the daily diary. Symptoms of nicotine withdrawal included craving for a cigarette; depressed mood; difficulty falling asleep; awakening at night; irritability, frustration, or anger; anxiety; difficulty concentrating; restlessness; and increased appetite. The severity of each symptom was scored by the subject on a five-point scale as absent (0), slight (1), mild (2), moderate (3), or severe (4). For each subject a base-line withdrawal score was calculated with data from all diaries completed before the start of medication, during which time the subjects were instructed to continue smoking their usual number of cigarettes. Withdrawal-symptom scores obtained after the target quitting date were analyzed as the change from base line. The data were summarized daily for the first week after the target quitting date and as weekly means for each of the next five weeks. For each group, the mean change in the withdrawal score was compared with zero by the one-sample t-test. The effect of treatment was evaluated with a two-factor repeated-measures analysis of variance model in which change in the withdrawal score was the dependent variable, treatment group was an independent cross-classification factor, and time was the repeated factor. Separate analyses were performed for the daily summary of week 1 and the weekly summary of the entire treatment phase. In addition to the overall model, separate pairwise analyses were performed that compared each active-treatment group with placebo.

Symptoms of depression were assessed with the Beck Depression Inventory15 at base line and at weeks 2 and 6 after the target quitting date. Depression scores were analyzed in terms of the change from base line. For each group, the mean change in the depression score was compared with zero by the one-sample t-test. The effect of treatment was evaluated with a two-factor repeated-measures analysis of variance model in which change in the depression score was the dependent variable, treatment group was an independent cross-classification factor, and time was the repeated factor. Fisher's exact test was used to compare the rates of adverse events for each active-treatment group with those in the placebo group.

Results

The base-line characteristics of the subjects are presented in Table 1Table 1Base-Line Characteristics of the Subjects.. There were no significant differences among the groups. A total of 219 subjects (148 during the treatment phase and 71 subsequently) did not complete the 12-month study. Of these subjects, 196 (89 percent) withdrew their consent for various reasons (e.g., scheduling difficulties or perceived lack of benefit); 15 stopped participating because of an adverse event, 6 because of protocol deviations, and 1 for administrative reasons; 1 subject died. The rate of completion of the study increased with the dose and was 57 percent, 65 percent, 64 percent, and 71 percent for the placebo, 100-mg, 150-mg, and 300-mg groups, respectively (P = 0.01 by logistic-regression analysis in which dose was treated as a continuous variable).

The biochemically confirmed point-prevalence smoking-cessation rates according to treatment are shown in Table 2Table 2Point-Prevalence Smoking-Cessation Rates Confirmed by Carbon Monoxide Measurement.. At the end of the treatment phase (week 6 after the target quitting date), the cessation rate for each of the three active-treatment groups was significantly better than for the placebo group. Subjects who received 300 mg of bupropion per day had a significantly better (P = 0.005) cessation rate than those who received 100 mg per day. The respective point-prevalence smoking-cessation rates at six weeks and one year were 19.0 percent and 12.4 percent in the placebo group and 44.2 percent and 23.1 percent in the group that received 300 mg of bupropion. At one year, the smoking-cessation rates for the 150-mg and 300-mg groups — but not the 100-mg group — were significantly better than that for the placebo group. When dose was treated as a continuous variable, a significant dose effect was detected at all periods (P<0.001 at week 6, P = 0.003 at 3 months, P = 0.03 at 6 months, and P = 0.02 at 12 months).

Figure 1Figure 1Rates of Confirmed Continuous Abstinence from the Target Quitting Date through the End of Treatment. shows the rates of continuous abstinence from the target quitting date through the end of treatment (10.5 percent in the placebo group, 13.7 percent in the 100-mg group, 18.3 percent in the 150-mg group, and 24.4 percent in the 300-mg group). The rate of continuous abstinence was significantly better in the group that received 300 mg of bupropion than in the placebo group (P = 0.001) and in the group that received 100 mg of bupropion (P = 0.02).

Weight Change

The mean change in weight from the start of medication (base line) for the 103 subjects who were continuously abstinent during the treatment phase is shown in Figure 2Figure 2Mean Change in Weight from Base Line through the End of Treatment among 103 Subjects Who Were Continuously Abstinent.. At the end of treatment, the subjects had gained a mean of 2.9 kg in the placebo group (16 subjects), 2.3 kg in the 100-mg group (21 subjects) and the 150-mg group (28 subjects), and 1.5 kg in the 300-mg group (38 subjects). Weight change was negatively associated with the dose (P = 0.003, by repeated-measures analysis of variance), with evidence of an interaction between dose and time (P = 0.04) that indicated a larger disparity between doses at later periods. For each of the first six weeks after the target quitting date, weight change was negatively associated with dose, with less weight gain found with higher doses of bupropion. Of the 59 subjects who were continuously abstinent from the target quitting date to the six-month follow-up visit, the mean weight gain was not significantly associated with dose: 5.5 kg in the placebo group (9 subjects), 6.6 kg in the 100-mg group (10 subjects), 4.4 kg in the 150-mg group (21 subjects), and 4.5 kg in the 300-mg group (19 subjects).

Symptoms of Depression and Withdrawal

During the medication phase, there was no evidence of a difference in change among treatment groups in the mean scores on the Beck Depression Inventory. In addition, the change in scores from base line was not significantly different from zero for any group either two weeks after the target quitting date (mean ±SD change, -0.3±4.7 in the placebo group [121 subjects], +0.4±4.1 in the 100-mg group [124 subjects], +0.6±4.9 in the 150-mg group [123 subjects], and +0.3±5.0 in the 300-mg group [128 subjects]) or at the end of treatment (-0.8±4.7 [103 subjects]; +0.5±5.5 [115 subjects]; -0.4±5.7 [110 subjects], and +0.8±5.2 [128 subjects], respectively).

The mean changes from base line in the composite withdrawal scores are shown in Figure 3Figure 3Mean Change from Base Line in the Withdrawal Score.. For each group, the mean change from base line was significantly greater than zero (i.e., withdrawal symptoms increased) at all periods. For the first week after the target quitting date, the change in the withdrawal scores was not significantly different among the four treatment groups. In the analysis of the weekly means, a significant treatment effect was detected (P<0.001). From the pairwise comparisons of the active-treatment groups with the placebo group, only the 100-mg group had significantly more withdrawal symptoms (P = 0.008) than the placebo group. There were no significant interactions between time and treatment.

Despite explicit instructions to the contrary, seven subjects used nicotine-replacement products during the study, only one of whom stopped smoking at any point. That subject chewed one piece of nicotine gum on day 17 before remembering he was not to do so.

Safety

All adverse events reported one or more times by at least 10 percent of subjects in any given treatment group are shown in Table 3Table 3Adverse Events among Subjects.. A total of 37 subjects stopped treatment prematurely because of adverse events (8 in the placebo group [5 percent], 9 in the 100-mg group [6 percent], 7 in the 150-mg group [5 percent], and 13 in the 300-mg group [8 percent]). Tremor, headaches, rash, and urticaria were the most common reasons for stopping treatment.

Three serious adverse events were reported during or immediately after the medication phase. A 23-year-old man assigned to receive 300 mg of bupropion per day reported extreme irritability, restlessness, anger, anxiety, and cravings soon after he stopped smoking. The study medication was stopped, and he began treatment with a nicotine patch. Two days later he was doing well. A 66-year-old woman assigned to the 300-mg group had an allergic reaction manifested by a pruritic rash, angioedema, dyspnea, and petechiae. She had received bupropion for 24 days, but had begun taking amoxicillin–clavulanate for the treatment of bronchitis 8 days before the onset of the reaction. The bupropion and amoxicillin–clavulanate were stopped, and the reaction resolved after treatment with antihistamines, epinephrine, and corticosteroids. The reaction was judged to be most likely related to amoxicillin–clavulanate. A 63-year-old woman with preexisting cardiomyopathy and hypertension had cardiac and pulmonary arrest four days after completing the treatment phase (300-mg group) and died nine days later.

Discussion

We found that the sustained-release form of bupropion was an effective treatment for smoking cessation, although many participants in all groups were smoking at one year. There was a significant dose response at all periods. Furthermore, the rates of abstinence at one year were significantly better in the 150-mg group (P = 0.02) and the 300-mg group (P = 0.01) than in the placebo group. Although the 300-mg dose was the most effective initially, its effects were not significantly different from those of the 150-mg dose at the end of treatment or at one year. Nonetheless, the 300-mg dose was the only one to show a difference in the rates of continuous abstinence from the target quitting date through the end of treatment. Thus, we would recommend using the 300-mg dose (150 mg twice a day) as the target dose for most patients, given the favorable side-effect profile and the fact that there was less weight gain during the medication phase with this dose. Because steady-state plasma levels of bupropion are usually reached within eight days, we started the medication at least seven days before the target quitting date in order to ensure that these levels were attained.18 We used bupropion for seven weeks on the basis of pilot studies and experience with nicotine-patch therapy, which showed that extending treatment beyond eight weeks does not appear to increase efficacy.19 Although this duration of therapy may be adequate, a longer duration may be appropriate if relapse is a concern. Antidepressants are commonly used for several months to treat depression or chronic pain and have little potential for abuse. We did not, however, study a longer duration of treatment.

Another important finding was the significantly smaller weight gain in subjects who continuously abstained from smoking and who were receiving higher doses of bupropion. The typical weight gain associated with successful smoking cessation is 3 to 4 kg,20 and it is a concern that inhibits many smokers (especially women) from attempting to stop.21 Nicotine-replacement therapy has had mixed results in controlling weight gain after smoking cessation,22-27 with nicotine gum and nicotine nasal spray showing the greatest benefit. A medication effective for smoking cessation that is also capable of minimizing the associated weight gain would offer a major advantage.28 Bupropion seems to have that potential, even though the differences observed were moderate, and the effect seems to be limited to the time the drug is used. The effect of a longer treatment period on weight gain has not been determined.

Nicotine activates central nervous system pathways to release norepinephrine, dopamine, and other neurotransmitters29,30 and elevates dopamine levels in areas of the brain associated with the reinforcement of the effects of amphetamines, cocaine, and opiates.31-33 Bupropion is a weak inhibitor of the neuronal uptake of norepinephrine and dopamine but has no effect on serotonin.34 Its dopaminergic and noradrenergic activities could be responsible for its efficacy in smoking cessation, with the dopaminergic activity affecting areas of the brain having to do with the reinforcement properties of addictive drugs and the noradrenergic activity affecting nicotine withdrawal.34 We observed no treatment effects on depression scores as measured serially by the Beck Depression Inventory; thus, the mechanism for bupropion's efficacy is unlikely to be through its antidepressant effects. However, subjects with current depression were excluded from this study. Further study is needed for a full understanding of the responsible mechanisms.

Bupropion was well tolerated, with the most frequent adverse effects being headache, insomnia, and dry mouth. Antidepressants are associated with a small risk of seizure.35 For sustained-release bupropion used for the treatment of depression, this risk is 0.1 percent for doses of up to 300 mg per day (i.e., one seizure per 1000 subjects receiving bupropion for varying periods of time — from a few weeks to more than a year).36 Our study lacked adequate power to evaluate seizures at these low rates. None of the 462 subjects in this study who received bupropion had a seizure. However, we excluded potential subjects who had a personal or family history of seizures, a history of severe head trauma, eating disorders, or active alcoholism. In clinical practice, patients should be screened for the possibility of seizure before they start treatment with bupropion.

Even though relief of nicotine-withdrawal symptoms is not a prerequisite for smoking cessation, we were puzzled by the finding that subjects who received 100 mg of bupropion a day had a higher mean score for withdrawal symptoms. A possible explanation is that a dose of 50 mg twice a day was sufficient to produce side effects that could be interpreted as similar to withdrawal symptoms, but was not sufficient to reduce the severity of true withdrawal symptoms.

The strengths of our study are the sample size, the use of multiple centers, the dose response, and the efficacy demonstrated by point-prevalence rates and rates of continuous abstinence. However, subjects who enroll in clinical trials are motivated to stop smoking and may not be representative of the general population of smokers. Much remains to be learned, such as the optimal duration of treatment, the potential role of combination therapy with nicotine-replacement products, and the use of bupropion for smoking cessation in smokers with depression.

Supported by a grant from Glaxo Wellcome.

We are indebted to the following people for their hard work and assistance in completing this project: Marilyn Eischen, Karen Hurtis, and Troy Wolter from the Mayo Clinic; Paul M. Maloney, Lynne D. Rowe, R.N., Alicia B. Gonzales, Susan L. Winget, Carol A. Sontag, R.N., and Barbara Newman from the Palo Alto Center for Pulmonary Disease Prevention; and Connie Cerullo and Anna Greco from the West Virginia University Health Sciences Center.

Source Information

From the Nicotine Research Center (R.D.H., L.C.D., I.T.C.), the Section of Biostatistics (K.P.O., D.R.S.), and the Division of Community Internal Medicine (R.D.H., L.C.D.), Mayo Clinic and Mayo Foundation, Rochester, Minn.; the Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, Calif. (D.P.L.S.); Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown (E.D.G., P.N.G., C.R.S., P.M.S.); and Glaxo Wellcome, Inc., Research Triangle Park, N.C. (J.A.J., M.A.K.).

Address reprint requests to Dr. Hurt at the Mayo Clinic, 200 First St. SW, Rochester, MN 55905.

References

References

  1. 1

    Glassman AH, Helzer JE, Covey LS, et al. Smoking, smoking cessation, and major depression. JAMA 1990;264:1546-1549
    CrossRef | Web of Science | Medline

  2. 2

    Hall SM, Munoz R, Reus V. Smoking cessation, depression and dysphoria. NIDA Res Monogr 1991;105:312-313

  3. 3

    Glass RM. Blue mood, blackened lungs: depression and smoking. JAMA 1990;264:1583-1584
    CrossRef | Web of Science | Medline

  4. 4

    Hughes JR. Dependence potential and abuse liability of nicotine replacement therapies. In: Pomerleau O, Pomerleau C, eds. Progress in clinical evaluation. New York: Alan R. Liss, 1988:261-77.

  5. 5

    Covey LS, Glassman AH, Stetner F. Depression and depressive symptoms in smoking cessation. Compr Psychiatry 1990;31:350-354
    CrossRef | Web of Science | Medline

  6. 6

    Hall SM, Munoz RF, Reus VI. Cognitive-behavioral intervention increases abstinence rates for depressive-history smokers. J Consult Clin Psychol 1994;62:141-146
    CrossRef | Web of Science | Medline

  7. 7

    Shiffman S. Relapse following smoking cessation: a situational analysis. J Consult Clin Psychol 1982;50:71-86
    CrossRef | Web of Science | Medline

  8. 8

    Edwards NB, Murphy JK, Downs AD, Ackerman BJ, Rosenthal TL. Doxepin as an adjunct to smoking cessation: a double-blind pilot study. Am J Psychiatry 1989;146:373-376
    Web of Science | Medline

  9. 9

    Sellers EM, Naranjo C, Kadlec K. Do serotonin uptake inhibitors decrease smoking? Observations in a group of heavy drinkers. J Clin Psychopharmacol 1987;7:417-420
    CrossRef | Web of Science | Medline

  10. 10

    Ferry LH, Burchette RJ. Efficacy of bupropion for smoking cessation in non-depressed smokers. J Addict Dis 1994;13:249-249
    Web of Science

  11. 11

    Spitzer RL, Williams JBW, Gibbon M, First MB. User's guide for the structured clinical interview for DSM-III-R: SCID. Washington, D.C.: American Psychiatric Press, 1990.

  12. 12

    Glynn TJ, Manley MW. How to help your patients stop smoking: a National Cancer Institute manual for physicians. Bethesda, Md.: National Cancer Institute, 1990. (NIH publication no. 90-3064.)

  13. 13

    Hughes JR, Hatsukami D. Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 1986;43:289-294
    CrossRef | Web of Science | Medline

  14. 14

    Fagerstrom KO. Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav 1978;3:235-241
    CrossRef | Web of Science | Medline

  15. 15

    Beck AT, Steer RA. Beck Depression Inventory. Philadelphia: Center for Cognitive Therapy, 1978.

  16. 16

    Swenson WM, Morse RM. The use of a self-administered alcoholism screening test (SAAST) in a medical center. Mayo Clin Proc 1975;50:204-208
    Web of Science | Medline

  17. 17

    Fagerstrom KO, Schneider NG. Measuring nicotine dependence: a review of the Fagerström Tolerance Questionnaire. J Behav Med 1989;12:159-182
    CrossRef | Web of Science | Medline

  18. 18

    Ferris RM, Cooper BR. Mechanism of antidepressant activity of bupropion. J Clin Psychiatry Monogr 1993;11:2-14

  19. 19

    Fiore MC, Smith SS, Jorenby DE, Baker TB. The effectiveness of the nicotine patch for smoking cessation: a meta-analysis. JAMA 1994;271:1940-1947
    CrossRef | Web of Science | Medline

  20. 20

    Williamson DF, Madans J, Anda RF, Kleinman JC, Giovino GA, Byers T. Smoking cessation and severity of weight gain in a national cohort. N Engl J Med 1991;324:739-745
    Full Text | Web of Science | Medline

  21. 21

    Klesges RC, Somes GW, Pascale R, et al. Knowledge and beliefsregarding the consequences of cigarette smoking and their relationshipsto smoking status in a biracial sample. Health Psychol 1988;7:387-401
    CrossRef | Web of Science | Medline

  22. 22

    Tonnesen P, Fryd V, Hansen M, et al. Effect of nicotine chewing gum in combination with group counseling on the cessation of smoking. N Engl J Med 1988;318:15-18
    Full Text | Web of Science | Medline

  23. 23

    Nides M, Rand C, Dolce J, et al. Weight gain as a function of smoking cessation and 2-mg nicotine gum use among middle-aged smokers with mild lung impairment in the first 2 years of the Lung Health Study. Health Psychol 1994;13:354-361
    CrossRef | Web of Science | Medline

  24. 24

    Leischow SJ, Sachs DPL, Bostrom AG, Hansen MD. Effects of differing nicotine-replacement doses on weight gain after smoking cessation. Arch Fam Med 1992;1:233-237
    CrossRef | Medline

  25. 25

    Transdermal Nicotine Study Group. Transdermal nicotine for smoking cessation: six-month results from two multicenter controlled clinical trials. JAMA 1991;266:3133-3138
    CrossRef | Web of Science

  26. 26

    Sachs DPL, Sawe U, Leischow SJ. Effectiveness of a 16-hour transdermal nicotine patch in a medical practice setting, without intensive group counseling. Arch Intern Med 1993;153:1881-1890[Erratum, Arch Intern Med 1993;153:2321.]
    CrossRef | Web of Science | Medline

  27. 27

    Sutherland G, Stapleton JA, Russell MA, et al. Randomized controlled trial of nasal nicotine spray in smoking cessation. Lancet 1992;340:324-329
    CrossRef | Web of Science | Medline

  28. 28

    Perkins KA. Issues in the prevention of weight gain after smoking cessation. Ann Behav Med 1994;16:46-52

  29. 29

    Gilman AG, Rall TW, Nies AS, Taylor P, eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1988.

  30. 30

    Wise RA. Brain neuronal systems mediating reward processes. In: Smith JE, Lane JD, eds. Neurobiology of opiate reward mechanisms. New York: Elsevier Biomedical Press, 1983:405-38.

  31. 31

    Di Chiara G, Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 1988;85:5274-5278
    CrossRef | Web of Science | Medline

  32. 32

    Pontieri FE, Tanda G, Orzi F, Di Chiara G. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 1996;382:255-257
    CrossRef | Web of Science | Medline

  33. 33

    Clarke PB. Nicotine dependence -- mechanisms and therapeutic strategies. Biochem Soc Symp 1993;59:83-95
    Web of Science | Medline

  34. 34

    Ascher JA, Cole JO, Colin JN, et al. Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry 1995;56:395-401
    Web of Science | Medline

  35. 35

    Davidson J. Seizures and bupropion: a review. J Clin Psychiatry 1989;50:256-261
    Web of Science | Medline

  36. 36

    Johnston JA, Lineberry CG, Ascher JA, et al. A 102-center prospective study of seizure in association with bupropion. J Clin Psychiatry 1991;52:450-456
    Web of Science | Medline

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    CrossRef

  2. 2

    Amanda C Farley, Peter Hajek, Deborah Lycett, Paul Aveyard, Paul Aveyard. 2012. Interventions for preventing weight gain after smoking cessation. .
    CrossRef

  3. 3

    Charles L. Pickens, Carlo Cifani, Brittany M. Navarre, Hila Eichenbaum, Florence R. Theberge, Michael H. Baumann, Donna J. Calu, Yavin Shaham. (2011) Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model. Psychopharmacology
    CrossRef

  4. 4

    Richard D. Hurt, Jon O. Ebbert, J. Taylor Hays, David D. McFadden. (2011) Preventing Lung Cancer by Treating Tobacco Dependence. Clinics in Chest Medicine 32:4, 645-657
    CrossRef

  5. 5

    Robert A. Schnoll, E. Paul Wileyto, Caryn Lerman. (2011) Extended Duration Therapy with Transdermal Nicotine may Attenuate Weight Gain Following Smoking Cessation. Addictive Behaviors
    CrossRef

  6. 6

    Maher Karam-Hage, Stephen Strobbe, Jason D. Robinson, Kirk J. Brower. (2011) Bupropion-SR for Smoking Cessation in Early Recovery from Alcohol Dependence: A Placebo-Controlled, Double-Blind Pilot Study. The American Journal of Drug and Alcohol Abuse 37:6, 487-490
    CrossRef

  7. 7

    L. David Hillis, Peter K. Smith, Jeffrey L. Anderson, John A. Bittl, Charles R. Bridges, John G. Byrne, Joaquin E. Cigarroa, Verdi J. DiSesa, Loren F. Hiratzka, Adolph M. Hutter, Michael E. Jessen, Ellen C. Keeley, Stephen J. Lahey, Richard A. Lange, Martin J. London, Michael J. Mack, Manesh R. Patel, John D. Puskas, Joseph F. Sabik, Ola Selnes, David M. Shahian, Jeffrey C. Trost, Michael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. Journal of the American College of Cardiology
    CrossRef

  8. 8

    J. Taylor Hays, David D. McFadden, Jon O. Ebbert. (2011) Pharmacologic Agents for Tobacco Dependence Treatment: 2011 Update. Current Atherosclerosis Reports
    CrossRef

  9. 9

    Harold S. Javitz, Gary E. Swan, Caryn Lerman. (2011) The dynamics of the urge-to-smoke following smoking cessation via pharmacotherapy. Addiction 106:10, 1835-1845
    CrossRef

  10. 10

    A. Eden Evins, Gladys Pachas, David Mischoulon, Karen Urbanoski, Sara Carlini, Jessica Sousa, Kate Bentley, Nancy A. Rigotti, Johanna Nino-Gomez, Tsafrir Loebl, Amy C. Janes, Marc J. Kaufman, Maurizio Fava. (2011) A Double-Blind, Placebo-Controlled Trial of the NMDA Glycine Site Antagonist, GW468816, for Prevention of Relapse to Smoking in Females. Journal of Clinical Psychopharmacology 31:5, 597-602
    CrossRef

  11. 11

    P. R. Killeen. (2011) Colloquium Paper: Markov model of smoking cessation. Proceedings of the National Academy of Sciences 108:Supplement_3, 15549-15556
    CrossRef

  12. 12

    Kirsty Danielson, Penelope Truman, Bronwyn M Kivell. (2011) The effects of nicotine and cigarette smoke on the monoamine transporters. Synapse 65:9, 866-879
    CrossRef

  13. 13

    Maria Caterina Grassi, Domenico Enea, Amy K. Ferketich, Bo Lu, Stefania Pasquariello, Paolo Nencini. (2011) Effectiveness of varenicline for smoking cessation: A 1-year follow-up study. Journal of Substance Abuse Treatment 41:1, 64-70
    CrossRef

  14. 14

    Eric C. Donny, Anthony R. Caggiula, Matthew T. Weaver, Melissa E. Levin, Alan F. Sved. (2011) The reinforcement-enhancing effects of nicotine: Implications for the relationship between smoking, eating and weight. Physiology & Behavior 104:1, 143-148
    CrossRef

  15. 15

    Shannon M. Clark, Ramzy Nakad. (2011) Pharmacotherapeutic Management of Nicotine Dependence in Pregnancy. Obstetrics and Gynecology Clinics of North America 38:2, 297-311
    CrossRef

  16. 16

    S. L. Catz, L. M. Jack, J. B. McClure, H. S. Javitz, M. Deprey, S. M. Zbikowski, T. McAfee, J. Richards, G. E. Swan. (2011) Adherence to Varenicline in the COMPASS Smoking Cessation Intervention Trial. Nicotine & Tobacco Research 13:5, 361-368
    CrossRef

  17. 17

    Robin Sperling, Kathryn G. Commons. (2011) Shifting topographic activation and 5-HT1A receptor-mediated inhibition of dorsal raphe serotonin neurons produced by nicotine exposure and withdrawal. European Journal of Neuroscience 33:10, 1866-1875
    CrossRef

  18. 18

    Elizabeth V. Ratchford, James H. Black. (2011) Approach to Smoking Cessation in the Patient With Vascular Disease. Current Treatment Options in Cardiovascular Medicine 13:2, 91-102
    CrossRef

  19. 19

    Carolyn M. Mazure, Benjamin Toll, Sherry A. McKee, Ran Wu, Stephanie S. O’Malley. (2011) Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion. Drug and Alcohol Dependence 114:1, 68-72
    CrossRef

  20. 20

    Hans-Ulrich Wittchen, Eva Hoch, Jens Klotsche, Stephan Muehlig. (2011) Smoking cessation in primary care - a randomized controlled trial of bupropione, nicotine replacements, CBT and a minimal intervention. International Journal of Methods in Psychiatric Research 20:1, 28-39
    CrossRef

  21. 21

    Keita Inoue, Fuminao Takeshima, Koichiro Kadota, Aya Yoda, Yoichi Tatsuta, Yuki Nagaura, Sumako Yoshioka, Seiko Nakamichi, Kazuhiko Nakao, Yoshiyuki Ozono. (2011) Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance. Internal Medicine 50:7, 707-712
    CrossRef

  22. 22

    Edward D. Levin, Susan Slade, Corinne Wells, Margaret Pruitt, Vanessa Cousins, Marty Cauley, Ann Petro, Dawn Hampton, Jed Rose. (2011) Histamine H1 antagonist treatment with pyrilamine reduces nicotine self-administration in rats. European Journal of Pharmacology 650:1, 256-260
    CrossRef

  23. 23

    Yann S. Mineur, Marina R. Picciotto. (2010) Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends in Pharmacological Sciences 31:12, 580-586
    CrossRef

  24. 24

    Adrie W. Bruijnzeel, Mahendra Bishnoi, Irma A. Tuijl, Kim F. M. Keijzers, Kate R. Yavarovich, Tim M. Pasek, Jenna Ford, Jon C. Alexander, Hidetaka Yamada. (2010) Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats. Psychopharmacology 212:4, 485-499
    CrossRef

  25. 25

    David Gonzales, Douglas E. Jorenby, Thomas H. Brandon, Carmen Arteaga, Theodore C. Lee. (2010) Immediate versus delayed quitting and rates of relapse among smokers treated successfully with varenicline, bupropion SR or placebo. Addiction 105:11, 2002-2013
    CrossRef

  26. 26

    Mark A. Frye, Giulio Perugi. 2010. Comorbidity in Bipolar Disorder: A Focus on Addiction and Anxiety Disorders. , 31-43.
    CrossRef

  27. 27

    Svetlana Semenova, Athina Markou. (2010) The α2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats. European Neuropsychopharmacology 20:10, 731-746
    CrossRef

  28. 28

    Tam Spitzer Johnson. (2010) A brief review of pharmacotherapeutic treatment options in smoking cessation: bupropion versus varenicline. Journal of the American Academy of Nurse Practitioners 22:10, 557-563
    CrossRef

  29. 29

    Arthur L. Brody, Edythe D. London, Richard E. Olmstead, Zoe Allen-Martinez, Stephanie Shulenberger, Matthew R. Costello, Anna L. Abrams, David Scheibal, Judah Farahi, Steven Shoptaw, Mark A. Mandelkern. (2010) Smoking-induced change in intrasynaptic dopamine concentration: Effect of treatment for Tobacco Dependence. Psychiatry Research: Neuroimaging 183:3, 218-224
    CrossRef

  30. 30

    Lisa J. Merlo, Kimberly G. Blumenthal, Kendall Campbell, Morrow Omli, Mark S. Gold. 2010. Pharmacological Therapeutics for Relapse Reduction in Addictive Disorders. , 503-523.
    CrossRef

  31. 31

    Firas H. Kobeissy, Carolina F. Braga, Noni A. Graham, Mark S. Gold. 2010. Pharmacological Therapeutics for Detoxification in Addictive Disorders. , 481-502.
    CrossRef

  32. 32

    Sura Alwan, Jennita Reefhuis, Lorenzo D. Botto, Sonja A. Rasmussen, Adolfo Correa, Jan M. Friedman. (2010) Maternal use of bupropion and risk for congenital heart defects. American Journal of Obstetrics and Gynecology 203:1, 52.e1-52.e6
    CrossRef

  33. 33

    Amit Sood, Jon O. Ebbert, Kavita Prasad, Ivana T. Croghan, Brent Bauer, Darrell R. Schroeder. (2010) A Randomized Clinical Trial of St. John's Wort for Smoking Cessation. The Journal of Alternative and Complementary Medicine 16:7, 761-767
    CrossRef

  34. 34

    James H. Black. (2010) Evidence base and strategies for successful smoking cessation. Journal of Vascular Surgery 51:6, 1529-1537
    CrossRef

  35. 35

    Austin G. Stack, Bhamidipati V.R. Murthy. (2010) Cigarette Use and Cardiovascular Risk in Chronic Kidney Disease: An Unappreciated Modifiable Lifestyle Risk Factor. Seminars in Dialysis 23:3, 298-305
    CrossRef

  36. 36

    Jon O. Ebbert, J. Taylor Hays, Richard D. Hurt. (2010) Combination Pharmacotherapy for Stopping Smoking. Drugs 70:6, 643-650
    CrossRef

  37. 37

    G. J. Madden, D. Kalman. (2010) Effects of bupropion on simulated demand for cigarettes and the subjective effects of smoking. Nicotine & Tobacco Research 12:4, 416-422
    CrossRef

  38. 38

    Alice Egerton, John P. Shotbolt, Paul R.A. Stokes, Ella Hirani, Rabia Ahmad, Julia M. Lappin, Suzanne J. Reeves, Mitul A. Mehta, Oliver D. Howes, Paul M. Grasby. (2010) Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: An [11C]raclopride PET study. NeuroImage 50:1, 260-266
    CrossRef

  39. 39

    Charles S. Wilcox, Nader Oskooilar, Janelle S. Erickson, Sonja K. Billes, Barbara B. Katz, Gary Tollefson, Eduardo Dunayevich. (2010) An open-label study of naltrexone and bupropion combination therapy for smoking cessation in overweight and obese subjects. Addictive Behaviors 35:3, 229-234
    CrossRef

  40. 40

    Thomas J. Kiernan, Brian G. Hynes, Nicholas J. Ruggiero, Bryan P. Yan, Michael R. Jaff. (2010) Comprehensive Evaluation and Medical Management of Infrainguinal Peripheral Artery Disease: “When to Treat, When Not to Treat”. Techniques in Vascular and Interventional Radiology 13:1, 2-10
    CrossRef

  41. 41

    Sarwar Hussain, Laurie Zawertailo, Usoa Busto, Martin Zack, Peter Farvolden, Peter Selby. (2010) The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: A randomized controlled trial in unmotivated smokers. Addictive Behaviors 35:2, 164-167
    CrossRef

  42. 42

    Mark J. Eisenberg, Lisa M. Blum, Kristian B. Filion, Stephane Rinfret, Louise Pilote, Gilles Paradis, Lawrence Joseph, André Gervais, Jennifer O’Loughlin. (2010) The efficacy of smoking cessation therapies in cardiac patients: A meta-analysis of randomized controlled trials. Canadian Journal of Cardiology 26:2, 73-79
    CrossRef

  43. 43

    Allen Azizian, Liam J Nestor, Doris Payer, John R Monterosso, Arthur L Brody, Edythe D London. (2010) Smoking Reduces Conflict-Related Anterior Cingulate Activity in Abstinent Cigarette Smokers Performing a Stroop Task. Neuropsychopharmacology 35:3, 775-782
    CrossRef

  44. 44

    B. A. Toll, S. Martino, A. Latimer, P. Salovey, S. O'Malley, S. Carlin-Menter, J. Hopkins, R. Wu, P. Celestino, K. M. Cummings. (2010) Randomized Trial: Quitline Specialist Training in Gain-Framed vs Standard-Care Messages for Smoking Cessation. JNCI Journal of the National Cancer Institute 102:2, 96-106
    CrossRef

  45. 45

    T.R. Kosten, D.E. Davis. 2010. Comorbidity – Depression. , 308-316.
    CrossRef

  46. 46

    M. J. Lewis, G. Balaji, H. Dixon, Y. Syed, K. E. Lewis. (2010) Influence of smoking abstinence and nicotine replacement therapy on heart rate and QT time-series. Clinical Physiology and Functional Imaging 30:1, 43-50
    CrossRef

  47. 47

    Bianca Jupp, Andrew J. Lawrence. (2010) New horizons for therapeutics in drug and alcohol abuse. Pharmacology & Therapeutics 125:1, 138-168
    CrossRef

  48. 48

    Matthew I. Palmatier, Melissa E. Levin, Kara L. Mays, Eric C. Donny, Anthony R. Caggiula, Alan F. Sved. (2009) Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats. Psychopharmacology 207:3, 381-390
    CrossRef

  49. 49

    C. A. Oncken, H. R. Kranzler. (2009) What do we know about the role of pharmacotherapy for smoking cessation before or during pregnancy?. Nicotine & Tobacco Research 11:11, 1265-1273
    CrossRef

  50. 50

    Maya J. Salameh, Elizabeth V. Ratchford. (2009) Update on Peripheral Arterial Disease and Claudication Rehabilitation. Physical Medicine and Rehabilitation Clinics of North America 20:4, 627-656
    CrossRef

  51. 51

    Luíz Cláudio Martins, Sílvia Elaine Ferreira-Melo, Maricene Sabha, Otávio Rizzi Coelho, Juan Carlos Yugar-Toledo, Thiago Quinaglia, Marcos Mello Moreira, Antonio Coca, Heitor Moreno Júnior. (2009) Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers. Blood Pressure 18:5, 255-260
    CrossRef

  52. 52

    Shannon Gravely-Witte, Donna E. Stewart, Neville Suskin, Sherry L. Grace. (2009) The association among depressive symptoms, smoking status and antidepressant use in cardiac outpatients. Journal of Behavioral Medicine 32:5, 478-490
    CrossRef

  53. 53

    D. R. Strong, C. W. Kahler, A. M. Leventhal, A. M. Abrantes, E. Lloyd-Richardson, R. Niaura, R. A. Brown. (2009) Impact of bupropion and cognitive-behavioral treatment for depression on positive affect, negative affect, and urges to smoke during cessation treatment. Nicotine & Tobacco Research 11:10, 1142-1153
    CrossRef

  54. 54

    Shoab A. Nazir, Marcia L. Erbland. (2009) Chronic Obstructive Pulmonary Disease. Drugs & Aging 26:10, 813-831
    CrossRef

  55. 55

    Peter Gariti, Kevin Lynch, Arthur Alterman, Klye Kampman, Hu Xie, Kristi Varillo. (2009) Comparing smoking treatment programs for lighter smokers with and without a history of heavier smoking. Journal of Substance Abuse Treatment 37:3, 247-255
    CrossRef

  56. 56

    Robert A. Schnoll, Freda Patterson. (2009) Sex heterogeneity in pharmacogenetic smoking cessation clinical trials. Drug and Alcohol Dependence 104, S94-S99
    CrossRef

  57. 57

    M. C. Grassi, D. Enea, A. K. Ferketich, B. Lu, P. Nencini. (2009) A smoking ban in public places increases the efficacy of bupropion and counseling on cessation outcomes at 1 year. Nicotine & Tobacco Research 11:9, 1114-1121
    CrossRef

  58. 58

    Fang Zheng, Matthew J. McConnell, Chang-Guo Zhan, Linda P. Dwoskin, Peter A. Crooks. (2009) QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(−)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorganic & Medicinal Chemistry 17:13, 4477-4485
    CrossRef

  59. 59

    George F. Koob, G. Kenneth Lloyd, Barbara J. Mason. (2009) Development of pharmacotherapies for drug addiction: a Rosetta Stone approach. Nature Reviews Drug Discovery 8:6, 500-515
    CrossRef

  60. 60

    Beatriz Roman. (2009) Patientsʼ Attitudes towards Generic Substitution of Oral Atypical Antipsychotics. CNS Drugs PAP,
    CrossRef

  61. 61

    Shadi Nahvi, Nina A. Cooperman. (2009) Review: The Need for Smoking Cessation Among HIV-Positive Smokers. AIDS Education and Prevention 21:3_supplement, 14-27
    CrossRef

  62. 62

    Yann S. Mineur, Marina R. Picciotto. (2009) Biological Basis for the Co-morbidity Between Smoking and Mood Disorders. Journal of Dual Diagnosis 5:2, 122-130
    CrossRef

  63. 63

    Deirdre A. Glynn, John F. Cryan, Pauline Kent, Robert A. Flynn, Marcus P. Kennedy. (2009) Update on smoking cessation therapies. Advances in Therapy 26:4, 369-382
    CrossRef

  64. 64

    Stuart G. Ferguson, Saul Shiffman. (2009) The relevance and treatment of cue-induced cravings in tobacco dependence. Journal of Substance Abuse Treatment 36:3, 235-243
    CrossRef

  65. 65

    Amrinder S. Bhatti, Cigdem Aydin, Ozge Oztan, Zhiyuan Ma, Penny Hall, Rui Tao, Ceylan Isgor. (2009) Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT. Psychopharmacology 203:1, 23-32
    CrossRef

  66. 66

    J. O. Ebbert, I. T. Croghan, A. Sood, D. R. Schroeder, J. T. Hays, R. D. Hurt. (2009) Varenicline and bupropion sustained-release combination therapy for smoking cessation. Nicotine & Tobacco Research 11:3, 234-239
    CrossRef

  67. 67

    Kavita Mundey. (2009) An appraisal of smoking cessation aids. Current Opinion in Pulmonary Medicine 15:2, 105-112
    CrossRef

  68. 68

    Nancy A. Rigotti, David Gonzales, Lowell C. Dale, Daniel Lawrence, Yuchiao Chang. (2009) A randomized controlled trial of adding the nicotine patch to rimonabant for smoking cessation: efficacy, safety and weight gain. Addiction 104:2, 266-276
    CrossRef

  69. 69

    Amanda C Parsons, Mujahed Shraim, Jennie Inglis, Paul Aveyard, Peter Hajek, Amanda C Parsons. 2009. Interventions for preventing weight gain after smoking cessation. .
    CrossRef

  70. 70

    Robert Swift, Lorenzo Leggio. 2009. Adjunctive Pharmacotherapy in the Treatment of Alcohol and Drug Dependence. , 287-310.
    CrossRef

  71. 71

    Neil E. Paterson. (2009) Behavioural and pharmacological mechanisms of bupropion's anti-smoking effects: Recent preclinical and clinical insights. European Journal of Pharmacology 603:1-3, 1-11
    CrossRef

  72. 72

    Michael A. Chandler, Stephen I. Rennard. 2009. Smoking Cessation. , 599-607.
    CrossRef

  73. 73

    Peter Jatlow, Benjamin A. Toll, Vanessa Leary, Suchitra Krishnan-Sarin, Stephanie S. O’Malley. (2008) Comparison of expired carbon monoxide and plasma cotinine as markers of cigarette abstinence. Drug and Alcohol Dependence 98:3, 203-209
    CrossRef

  74. 74

    Gerald Zernig, Reinhild Wallner, Ursula Grohs, Norbert Kriechbaum, Georg Kemmler, Alois Saria. (2008) A randomized trial of short psychotherapy versus sustained-release bupropion for smoking cessation. Addiction 103:12, 2024-2031
    CrossRef

  75. 75

    V. I. Reus, B. J. Smith. (2008) Multimodal techniques for smoking cessation: a review of their efficacy and utilisation and clinical practice guidelines. International Journal of Clinical Practice 62:11, 1753-1768
    CrossRef

  76. 76

    Piotr Tutka. (2008) Nicotinic receptor partial agonists as novel compounds for the treatment of smoking cessation. Expert Opinion on Investigational Drugs 17:10, 1473-1485
    CrossRef

  77. 77

    José Carlos Titos-Arcos, Hacibe Hallal, Virginia Collados, Joaquín Plaza-Aniorte. (2008) Hepatitis aguda secundaria a bupropión. Gastroenterología y Hepatología 31:8, 549
    CrossRef

  78. 78

    Andrea H. Weinberger, Jennifer C. Vessicchio, Kristi A. Sacco, Cerissa L. Creeden, K.N. Roy Chengappa, Tony P. George. (2008) A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Disorder. Journal of Clinical Psychopharmacology 28:5, 584-587
    CrossRef

  79. 79

    Danielle E. McCarthy, Thomas M. Piasecki, Daniel L. Lawrence, Douglas E. Jorenby, Saul Shiffman, Timothy B. Baker. (2008) Psychological mediators of bupropion sustained-release treatment for smoking cessation. Addiction 103:9, 1521-1533
    CrossRef

  80. 80

    Nicolas Rodondi, Pascal Bovet, Daniel Hayoz, Jacques Cornuz. (2008) The Impact of CAROtid plaque Screening on Smoking (CAROSS) cessation and control of other cardiovascular risk factors: Rationale and design of a randomized controlled trial. Contemporary Clinical Trials 29:5, 767-773
    CrossRef

  81. 81

    Hao Wang, Daniel F. Heitjan. (2008) Modeling heaping in self‐reported cigarette counts. Statistics in Medicine 27:19, 3789-3804
    CrossRef

  82. 82

    Kevin W. Johns, Jiri F. Frohlich, Gregory P. Bondy. (2008) Pharmacology of drugs used to treat smoking cessation and obesity. Canadian Journal of Cardiology 24, 22C-26C
    CrossRef

  83. 83

    Jun'ichi Semba, Maki Wakuta. (2008) Chronic effect of nicotine on serotonin transporter mRNA in the raphe nucleus of rats: Reversal by co-administration of bupropion. Psychiatry and Clinical Neurosciences 62:4, 435-441
    CrossRef

  84. 84

    D Bhattacharyya, SP Rai, LS Neog. (2008) Therapy for cessation of smoking. Medical Journal Armed Forces India 64:3, 254-259
    CrossRef

  85. 85

    Ixchel Herrera-Guzmán, Esteve Gudayol-Ferré, Jennifer Lira-Mandujano, Jorge Herrera-Abarca, Daniel Herrera-Guzmán, Karina Montoya-Pérez, Joan Guardia-Olmos. (2008) Cognitive predictors of treatment response to bupropion and cognitive effects of bupropion in patients with major depressive disorder. Psychiatry Research 160:1, 72-82
    CrossRef

  86. 86

    D. V. Conti, W. Lee, D. Li, J. Liu, D. Van Den Berg, P. D. Thomas, A. W. Bergen, G. E. Swan, R. F. Tyndale, N. L. Benowitz, C. Lerman, . (2008) Nicotinic acetylcholine receptor  2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Human Molecular Genetics 17:18, 2834-2848
    CrossRef

  87. 87

    Reiji Yoshimura, Shingo Kakihara, Wakako Umene-Nakano, Atsuko Sugita, Hikaru Hori, Nobuhisa Ueda, Jun Nakamura. (2008) Acute risperidone treatment did not increase daily cigarette consumption or plasma levels of cotinine and caffeine: a pilot study. Human Psychopharmacology: Clinical and Experimental 23:4, 327-332
    CrossRef

  88. 88

    Neil E. Paterson, Svetlana Semenova, Athina Markou. (2008) The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat. Psychopharmacology 198:3, 351-362
    CrossRef

  89. 89

    Tony P. George, Jennifer C. Vessicchio, Kristi A. Sacco, Andrea H. Weinberger, Melissa M. Dudas, Taryn M. Allen, Cerissa L. Creeden, Marc N. Potenza, Alan Feingold, Peter I. Jatlow. (2008) A Placebo-Controlled Trial of Bupropion Combined with Nicotine Patch for Smoking Cessation in Schizophrenia. Biological Psychiatry 63:11, 1092-1096
    CrossRef

  90. 90

    Ziva D. Cooper, Margaret Haney. (2008) Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor. Addiction Biology 13:2, 188-195
    CrossRef

  91. 91

    Spence M. Taylor, Corey A. Kalbaugh, Matthew G. Healy, Anna L. Cass, Bruce H. Gray, Eugene M. Langan, David L. Cull, Christopher G. Carsten, John W. York, Bruce A. Snyder, Jerry R. Youkey. (2008) Do Current Outcomes Justify More Liberal Use of Revascularization for Vasculogenic Claudication? A Single Center Experience of 1,000 Consecutively Treated Limbs. Journal of the American College of Surgeons 206:5, 1053-1062
    CrossRef

  92. 92

    Su-Yan L Barrow. (2008) Is your knowledge up-to-date?. International Journal of Dental Hygiene 6:2, 150-151
    CrossRef

  93. 93

    Gisela I. Robles, Devada Singh-Franco, Hoytin Lee Ghin. (2008) A review of the efficacy of smoking-cessation pharmacotherapies in nonwhite populations. Clinical Therapeutics 30:5, 800-812
    CrossRef

  94. 94

    Andrea T. Borchers, Carl. L. Keen, M. Eric Gershwin. (2008) Smoking Cessation: Significance and Implications for Children. Clinical Reviews in Allergy & Immunology 34:2, 231-249
    CrossRef

  95. 95

    Curtis L. Cooper. (2008) Obstacles to Successful HCV Treatment in Substance Addicted Patients. Journal of Addictive Diseases 27:2, 61-68
    CrossRef

  96. 96

    Wilbert S. Aronow. 2008. Management of Peripheral Arterial Disease in the Elderly. , 749-768.
    CrossRef

  97. 97

    J.C. Virchow. (2008) Prävention von Erkrankungen des Respirationstrakts. Der Internist 49:2, 170-177
    CrossRef

  98. 98

    Xiu Liu, Anthony R. Caggiula, Matthew I. Palmatier, Eric C. Donny, Alan F. Sved. (2008) Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose. Psychopharmacology 196:3, 365-375
    CrossRef

  99. 99

    Doug-Hyun Han, Keun-Ho Joe, Chul Na, Young-Sik Lee. (2008) Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers. Psychiatric Genetics 18:1, 11-16
    CrossRef

  100. 100

    Benjamin A. Toll, Vanessa Leary, Ran Wu, Peter Salovey, Boris Meandzija, Stephanie S. O'Malley. (2008) A preliminary investigation of naltrexone augmentation of bupropion to stop smoking with less weight gain. Addictive Behaviors 33:1, 173-179
    CrossRef

  101. 101

    Matthias E Liechti, Athina Markou. (2008) Role of the Glutamatergic System in Nicotine Dependence. CNS Drugs 22:9, 705-724
    CrossRef

  102. 102

    Gary L Huber, Vijay K Mahajan. (2008) Successful Smoking Cessation. Disease Management & Health Outcomes 16:5, 335-343
    CrossRef

  103. 103

    Rajesh R Patel, Jay H Ryu, Robert Vassallo. (2008) Cigarette Smoking and Diffuse Lung Disease. Drugs 68:11, 1511-1527
    CrossRef

  104. 104

    Gary E Swan, Lisa M Jack, Harold S Javitz, Tim McAfee, Jennifer B McClure. (2008) Predictors of 12-Month Outcome in??Smokers Who Received Bupropion??Sustained-Release for??Smoking Cessation. CNS Drugs 22:3, 239-256
    CrossRef

  105. 105

    Marie-Nöelle Beyens, Claire Guy, Genevieve Mounier, Sylvie Laporte, Michel Ollagnier. (2008) Serious Adverse Reactions of Bupropion for Smoking Cessation. Drug Safety 31:11, 1017-1026
    CrossRef

  106. 106

    George S. Portugal, Thomas J. Gould. (2007) Bupropion dose-dependently reverses nicotine withdrawal deficits in contextual fear conditioning. Pharmacology Biochemistry and Behavior 88:2, 179-187
    CrossRef

  107. 107

    Shoab A. Nazir, Mohammad M. Al-Hamed, Marcia L. Erbland. (2007) Chronic Obstructive Pulmonary Disease in the Older Patient. Clinics in Chest Medicine 28:4, 703-715
    CrossRef

  108. 108

    Sheila A Doggrell. (2007) Which is the best primary medication for long-term smoking cessation – nicotine replacement therapy, bupropion or varenicline?. Expert Opinion on Pharmacotherapy 8:17, 2903-2915
    CrossRef

  109. 109

    Isabel Nerín, Pilar Novella, Asunción Beamonte, Pilar Gargallo, Adriana Jiménez-Muro, Adriana Marqueta. (2007) Resultados del tratamiento del tabaquismo en una unidad especializada. Archivos de Bronconeumología 43:12, 669-673
    CrossRef

  110. 110

    V. C. Wing, M. Shoaib. (2007) Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. Psychopharmacology 195:3, 303-313
    CrossRef

  111. 111

    Ivan D. Montoya, Frank Vocci. (2007) Medications Development for the Treatment of Nicotine Dependence in Individuals with Schizophrenia. Journal of Dual Diagnosis 3:3-4, 113-150
    CrossRef

  112. 112

    Teresa R Franklin, Ze wang, Jiongjiong Wang, Nathan Sciortino, Derek Harper, Yin Li, Ron Ehrman, Kyle Kampman, Charles P O'Brien, John A Detre, Anna Rose Childress. (2007) Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study. Neuropsychopharmacology 32:11, 2301-2309
    CrossRef

  113. 113

    Nicole M Stack. (2007) Smoking Cessation: An Overview of Treatment Options with a Focus on Varenicline. Pharmacotherapy 27:11, 1550-1557
    CrossRef

  114. 114

    J. Cornuz. (2007) Smoking Cessation Interventions in Clinical Practice. European Journal of Vascular and Endovascular Surgery 34:4, 397-404
    CrossRef

  115. 115

    Joseph C. Cappelleri, Andrew G. Bushmakin, Christine L. Baker, Elizabeth Merikle, Abayomi O. Olufade, David G. Gilbert. (2007) Multivariate framework of the Brief Questionnaire of Smoking Urges. Drug and Alcohol Dependence 90:2-3, 234-242
    CrossRef

  116. 116

    Gerhard Rammes, Rainer Rupprecht. (2007) Modulation of Ligand-gated Ion Channels by Antidepressants and Antipsychotics. Molecular Neurobiology 35:2, 160-174
    CrossRef

  117. 117

    Anna M. Lee, Christopher Jepson, Ewa Hoffmann, Leonard Epstein, Larry W. Hawk, Caryn Lerman, Rachel F. Tyndale. (2007) CYP2B6 Genotype Alters Abstinence Rates in a Bupropion Smoking Cessation Trial. Biological Psychiatry 62:6, 635-641
    CrossRef

  118. 118

    Caryn Lerman, Mark G. LeSage, Kenneth A. Perkins, Stephanie S. O'Malley, Steven J. Siegel, Neal L. Benowitz, William A. Corrigall. (2007) Translational research in medication development for nicotine dependence. Nature Reviews Drug Discovery 6:9, 746-762
    CrossRef

  119. 119

    Lowell C. Dale, Jon O. Ebbert, Elbert D. Glover, Ivana T. Croghan, Darrell R. Schroeder, Herbert H. Severson, Richard D. Hurt. (2007) Bupropion SR for the treatment of smokeless tobacco use. Drug and Alcohol Dependence 90:1, 56-63
    CrossRef

  120. 120

    Kathleen M. Grant, Stephanie Sinclair Kelley, Lynette M. Smith, Sangeeta Agrawal, James R. Meyer, Debra J. Romberger. (2007) Bupropion and nicotine patch as smoking cessation aids in alcoholics. Alcohol 41:5, 381-391
    CrossRef

  121. 121

    A. Eden Evins, Corinne Cather, Melissa A. Culhane, Alan Birnbaum, Jonathan Horowitz, Elaine Hsieh, Oliver Freudenreich, David C. Henderson, David A. Schoenfeld, Nancy A. Rigotti, Donald C. Goff. (2007) A 12-Week Double-Blind, Placebo-Controlled Study of Bupropion SR Added to High-Dose Dual Nicotine Replacement Therapy for Smoking Cessation or Reduction in Schizophrenia. Journal of Clinical Psychopharmacology 27:4, 380-386
    CrossRef

  122. 122

    Nimish Sidhpura, Peter Redfern, Susan Wonnacott. (2007) Comparison of the effects of bupropion on nicotinic receptor-evoked [3H]dopamine release from rat striatal synaptosomes and slices. European Journal of Pharmacology 567:1-2, 102-109
    CrossRef

  123. 123

    I. Mitrouska, I. Bouloukaki, N.M. Siafakas. (2007) Pharmacological approaches to smoking cessation. Pulmonary Pharmacology & Therapeutics 20:3, 220-232
    CrossRef

  124. 124

    Masakazu Nakamura, Akira Oshima, Yoko Fujimoto, Nami Maruyama, Taro Ishibashi, Karen R. Reeves. (2007) Efficacy and tolerability of varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers. Clinical Therapeutics 29:6, 1040-1056
    CrossRef

  125. 125

    Neil E. Paterson, David J. Balfour, Athina Markou. (2007) Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. European Journal of Neuroscience 25:10, 3099-3108
    CrossRef

  126. 126

    M K Ho, R F Tyndale. (2007) Overview of the pharmacogenomics of cigarette smoking. The Pharmacogenomics Journal 7:2, 81-98
    CrossRef

  127. 127

    Anthony J. Alberg, Cindy L. Carter, Matthew J. Carpenter. (2007) Weight gain as an impediment to cigarette smoking cessation: A lingering problem in need of solutions. Preventive Medicine 44:4, 296-297
    CrossRef

  128. 128

    Mary E. Becker, Michael A. Hertzberg, Scott D. Moore, Michelle F. Dennis, Deo S. Bukenya, Jean C. Beckham. (2007) A Placebo-Controlled Trial of Bupropion SR in the Treatment of Chronic Posttraumatic Stress Disorder. Journal of Clinical Psychopharmacology 27:2, 193-197
    CrossRef

  129. 129

    Jon O. Ebbert, Amit Sood, J Taylor Hays, Lowell C. Dale, Richard D. Hurt. (2007) Treating Tobacco Dependence: Review of the Best and Latest Treatment Options. Journal of Thoracic Oncology 2:3, 249-256
    CrossRef

  130. 130

    P Bredeloux, I Dubuc, J Costentin. (2007) Comparisons between bupropion and dexamphetamine in a range of in vivo tests exploring dopaminergic transmission. British Journal of Pharmacology 150:6, 711-719
    CrossRef

  131. 131

    Neil E. Paterson, Athina Markou. (2007) Animal models and treatments for addiction and depression co-morbidity. Neurotoxicity Research 11:1, 1-32
    CrossRef

  132. 132

    Anita H Clayton. (2007) Extended-release bupropion: an antidepressant with a broad spectrum of therapeutic activity?. Expert Opinion on Pharmacotherapy 8:4, 457-466
    CrossRef

  133. 133

    Eric C.K. Siu, Rachel F. Tyndale. (2007) Non-Nicotinic Therapies for Smoking Cessation. Annual Review of Pharmacology and Toxicology 47:1, 541-564
    CrossRef

  134. 134

    William H. Frishman. (2007) Smoking Cessation Pharmacotherapy?Nicotine and Non-Nicotine Preparations. Preventive Cardiology 10:s2, 10-22
    CrossRef

  135. 135

    Saadhna Panday, S. Priscilla Reddy, Robert A.C. Ruiter, Erik Bergström, Hein de Vries. (2007) Nicotine Dependence and Withdrawal Symptoms among Occasional Smokers. Journal of Adolescent Health 40:2, 144-150
    CrossRef

  136. 136

    Ivana T. Croghan, Richard D. Hurt, Shaker R. Dakhil, Gary A. Croghan, Jeff A. Sloan, Paul J. Novotny, Kendrith M. Rowland, Albert Bernath, Mary L. Loots, Nguyet A. Le-Lindqwister, Loren K. Tschetter, Stewart C. Garneau, Kathleen A. Flynn, Larry P. Ebbert, Donald B. Wender, Charles L. Loprinzi. (2007) Randomized Comparison of a Nicotine Inhaler and Bupropion for Smoking Cessation and Relapse Prevention. Mayo Clinic Proceedings 82:2, 186-195
    CrossRef

  137. 137

    I. T. Croghan, R. D. Hurt, S. R. Dakhil, G. A. Croghan, J. A. Sloan, P. J. Novotny, K. M. Rowland, A. Bernath, M. L. Loots, N. A. Le-Lindqwister, L. K. Tschetter, S. C. Garneau, K. A. Flynn, L. P. Ebbert, D. B. Wender, C. L. Loprinzi. (2007) Randomized Comparison of a Nicotine Inhaler and Bupropion for Smoking Cessation and Relapse Prevention. Mayo Clinic Proceedings 82:2, 186-195
    CrossRef

  138. 138

    John R Hughes, Lindsay F Stead, Tim Lancaster, John R Hughes. 2007. Antidepressants for smoking cessation. .
    CrossRef

  139. 139

    &NA;. (2007) Varenicline (Chantix) for Tobacco Dependence. Obstetrics & Gynecology 109:1, 192-193
    CrossRef

  140. 140

    Wade H. Berrettini, E. Paul Wileyto, Leonard Epstein, Stephanie Restine, Larry Hawk, Peter Shields, Ray Niaura, Caryn Lerman. (2007) Catechol-O-Methyltransferase (COMT) Gene Variants Predict Response to Bupropion Therapy for Tobacco Dependence. Biological Psychiatry 61:1, 111-118
    CrossRef

  141. 141

    Bernard Le Foll, Steven R Goldberg, Pierre Sokoloff. (2007) Dopamine D 3 receptor ligands for the treatment of tobacco dependence. Expert Opinion on Investigational Drugs 16:1, 45-57
    CrossRef

  142. 142

    Kishore M Gadde, Glen L Xiong. (2007) Bupropion for weight reduction. Expert Review of Neurotherapeutics 7:1, 17-24
    CrossRef

  143. 143

    David Olivier, Dan I. Lubman, Richard Fraser. (2007) Tobacco smoking within psychiatric inpatient settings: biopsychosocial perspective. Australian and New Zealand Journal of Psychiatry 41:7, 572-580
    CrossRef

  144. 144

    Yves Martinet, Abraham Bohadana, Nathalie Wirth, Anna Spinosa. 2007. Proposer les traitements disponibles. Prescrire un traitement adapté. , 50-72.
    CrossRef

  145. 145

    John C.M. Brust. 2007. Tabac. , 519-550.
    CrossRef

  146. 146

    Sandra A. Brown, Suzette V. Glasner-Edwards, Susan R. Tate, John R. McQuaid, John Chalekian, Eric Granholm. (2006) Integrated Cognitive Behavioral Therapy Versus Twelve-Step Facilitation Therapy for Substance-Dependent Adults with Depressive Disorders. Journal of Psychoactive Drugs 38:4, 449-460
    CrossRef

  147. 147

    James Shearer, Marian Shanahan. (2006) Cost effectiveness analysis of smoking cessation interventions. Australian and New Zealand Journal of Public Health 30:5, 428-434
    CrossRef

  148. 148

    A. Palou Rotger, E. Sala Llinàs. (2006) Enfermedad pulmonar obstructiva crónica (2). Medicine - Programa de Formación Médica Continuada Acreditado 9:63, 4080-4087
    CrossRef

  149. 149

    Linda P. Dwoskin, Anthony S. Rauhut, Kelley A. King-Pospisil, Michael T. Bardo. (2006) Review of the Pharmacology and Clinical Profile of Bupropion, an Antidepressant and Tobacco Use Cessation Agent. CNS Drug Reviews 12:3-4, 178-207
    CrossRef

  150. 150

    Robert A Schnoll, Caryn Lerman. (2006) Current and emerging pharmacotherapies for treating tobacco dependence. Expert Opinion on Emerging Drugs 11:3, 429-444
    CrossRef

  151. 151

    S LAWVERE, M MAHONEY, K CUMMINGS, J KEPNER, A HYLAND, D LAWRENCE, J MURPHY. (2006) A Phase II study of St. John's Wort for smoking cessation. Complementary Therapies in Medicine 14:3, 175-184
    CrossRef

  152. 152

    Himanshu P. Upadhyaya. (2006) DO PATIENTS WITH ADHD HAVE A HARDER TIME QUITTING CIGARETTES?. Journal of the American Academy of Child & Adolescent Psychiatry 45:8, 891
    CrossRef

  153. 153

    Marc E Mooney, Mehmet Sofuoglu. (2006) Bupropion for the treatment of nicotine withdrawal and craving. Expert Review of Neurotherapeutics 6:7, 965-981
    CrossRef

  154. 154

    Fábio M. Haggsträm, José M. Chatkin, Eliana Sussenbach-Vaz, Débora H. Cesari, Claudia F. Fam, Carlos C. Fritscher. (2006) A controlled trial of nortriptyline, sustained-release bupropion and placebo for smoking cessation: preliminary results. Pulmonary Pharmacology & Therapeutics 19:3, 205-209
    CrossRef

  155. 155

    Fang Zheng, Ersin Bayram, Sangeetha P. Sumithran, Joshua T. Ayers, Chang-Guo Zhan, Jeffrey D. Schmitt, Linda P. Dwoskin, Peter A. Crooks. (2006) QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release. Bioorganic & Medicinal Chemistry 14:9, 3017-3037
    CrossRef

  156. 156

    Oscar G Bukstein. (2006) Therapeutic challenges of attention-deficit hyperactivity disorder with substance use disorders. Expert Review of Neurotherapeutics 6:4, 541-549
    CrossRef

  157. 157

    Jacques Cornuz. (2006) Treating tobacco use and dependence in clinical practice. Expert Opinion on Pharmacotherapy 7:6, 783-792
    CrossRef

  158. 158

    Michael Kotlyar, Lisa H. Brauer, Mustafa al'Absi, David E. Adson, William Robiner, Paul Thuras, Jennifer Harris, Mary E. Finocchi, Carrie A. Bronars, Suzanne Candell, Dorothy K. Hatsukami. (2006) Effect of bupropion on physiological measures of stress in smokers during nicotine withdrawal. Pharmacology Biochemistry and Behavior 83:3, 370-379
    CrossRef

  159. 159

    Thomas M. Piasecki. (2006) Relapse to smoking. Clinical Psychology Review 26:2, 196-215
    CrossRef

  160. 160

    William H. Frishman, Walter Mitta, Adam Kupersmith, Tom Ky. (2006) Nicotine and Non-nicotine Smoking Cessation Pharmacotherapies. Cardiology in Review 14:2, 57-73
    CrossRef

  161. 161

    Mark G. LeSage, Daniel E. Keyler, Paul R. Pentel. (2006) Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies. The AAPS Journal 8:1, E65-E75
    CrossRef

  162. 162

    S. Cavuto, F. Bravi, M.C. Grassi, G. Apolone. (2006) Propensity score for the analysis of observational data: an introduction and an illustrative example. Drug Development Research 67:3, 208-216
    CrossRef

  163. 163

    Maria Caterina Grassi, Domenico Enea, Rosanna Marchetti, Alessio Maria Caricati, Paolo Nencini. (2006) Combined counseling and bupropion therapy for smoking cessation: identification of outcome predictors. Drug Development Research 67:3, 271-279
    CrossRef

  164. 164

    Eli V Gelfand, Christopher P Cannon. (2006) Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors. Expert Opinion on Investigational Drugs 15:3, 307-315
    CrossRef

  165. 165

    Rohit Arora, James R. Sowers, Elijah Saunders, Jeffrey Probstfield, Harold L. Lazar. (2006) Cardioprotective Strategies to Improve Long-Term Outcomes Following Coronary Artery Bypass Surgery. Journal of Cardiac Surgery 21:2, 198-204
    CrossRef

  166. 166

    Steven P. Marso, William R. Hiatt. (2006) Peripheral Arterial Disease in Patients With Diabetes. Journal of the American College of Cardiology 47:5, 921-929
    CrossRef

  167. 167

    Bernard Foll, Steven R. Goldberg. (2006) Nicotine as a typical drug of abuse in experimental animals and humans. Psychopharmacology 184:3-4, 367-381
    CrossRef

  168. 168

    David H. Malin, J. Ronald Lake, Tanya D. Smith, Habil N. Khambati, Rhonda L. Meyers-Paal, Ana L. Montellano, Ryan E. Jennings, Daniel S. Erwin, Stacey E. Presley, Barbara A. Perales. (2006) Bupropion attenuates nicotine abstinence syndrome in the rat. Psychopharmacology 184:3-4, 494-503
    CrossRef

  169. 169

    Kenneth A. Perkins, Maxine Stitzer, Caryn Lerman. (2006) Medication screening for smoking cessation: a proposal for new methodologies. Psychopharmacology 184:3-4, 628-636
    CrossRef

  170. 170

    Joel D. Killen, Stephen P. Fortmann, Greer M. Murphy, Chris Hayward, Christina Arredondo, DeAnn Cromp, Maria Celio, Laurie Abe, Yun Wang, Alan F. Schatzberg. (2006) Extended treatment with bupropion SR for cigarette smoking cessation.. Journal of Consulting and Clinical Psychology 74:2, 286-294
    CrossRef

  171. 171

    Jaimee L. Heffner, Suzan Winders-Barrett, Robert M. Anthenelli. 2006. Obesity and Smoking. , 123-144.
    CrossRef

  172. 172

    Wilbert S Aronow. (2006) Drug Treatment of Peripheral Arterial Disease in the Elderly. Drugs & Aging 23:1, 1-12
    CrossRef

  173. 173

    David A. Tate. 2006. Abuso de sustancias y corazón. , 573-577.
    CrossRef

  174. 174

    Anthony Rauhut, Linda Dwoskin, Michael Bardo. (2005) Tolerance does not develop to the decrease in nicotine self‐administration produced by repeated bupropion administration. Nicotine & Tobacco Research 7:6, 901-907
    CrossRef

  175. 175

    Delwyn Catley, Kari Jo Harris, Kolawole Okuyemi, Matthew Mayo, Evan Pankey, Jasjit Ahluwalia. (2005) The influence of depressive symptoms on smoking cessation among African Americans in a randomized trial of bupropion. Nicotine & Tobacco Research 7:6, 859-870
    CrossRef

  176. 176

    D OSLIN. (2005) Evidence-Based Treatment of Geriatric Substance Abuse. Psychiatric Clinics of North America 28:4, 897-911
    CrossRef

  177. 177

    Vincenzo Teneggi, Stephen T. Tiffany, Lisa Squassante, Stefano Milleri, Luigi Ziviani, Alan Bye. (2005) Effect of sustained-release (SR) bupropion on craving and withdrawal in smokers deprived of cigarettes for 72 h. Psychopharmacology 183:1, 1-12
    CrossRef

  178. 178

    Ramon Solhkhah, Timothy E. Wilens, Jeanine Daly, Jefferson B. Prince, Stephanie L. Van Patten, Joseph Biederman. (2005) Bupropion SR for the Treatment of Substance- Abusing Outpatient Adolescents with Attention- Deficit/Hyperactivity Disorder and Mood Disorders. Journal of Child and Adolescent Psychopharmacology 15:5, 777-786
    CrossRef

  179. 179

    Sarah Ross, David Williams. (2005) Bupropion: risks and benefits. Expert Opinion on Drug Safety 4:6, 995-1003
    CrossRef

  180. 180

    James W. Jefferson, James F. Pradko, Keith T. Muir. (2005) Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations. Clinical Therapeutics 27:11, 1685-1695
    CrossRef

  181. 181

    Lois E. Krahn, Andrea DiMartini. (2005) Psychiatric and psychosocial aspects of liver transplantation. Liver Transplantation 11:10, 1157-1168
    CrossRef

  182. 182

    T. Heitzer, T. Meinertz. (2005) Rauchen und koronare Herzkrankheit. Zeitschrift für Kardiologie 94:S3, iii30-iii42
    CrossRef

  183. 183

    H. McRobbie, M. Lee, Z. Juniper. (2005) Non-nicotine pharmacotherapies for smoking cessation. Respiratory Medicine 99:10, 1203-1212
    CrossRef

  184. 184

    Jon E. Grant, Marc N. Potenza. (2005) Tobacco Use and Pathological Gambling. Annals of Clinical Psychiatry 17:4, 237-241
    CrossRef

  185. 185

    William White, David Crockford, Scott Patten, Nady el‐Guebaly. (2005) A randomized, open‐label pilot comparison of gabapentin and bupropion SR for smoking cessation. Nicotine & Tobacco Research 7:5, 809-813
    CrossRef

  186. 186

    Charlotte Warner, Mohammed Shoaib. (2005) How does bupropion work as a smoking cessation aid?. Addiction Biology 10:3, 219-231
    CrossRef

  187. 187

    Margaret Haney. (2005) The marijuana withdrawal syndrome: Diagnosis and treatment. Current Psychiatry Reports 7:5, 360-366
    CrossRef

  188. 188

    T. R. Frieden, D. E. Blakeman. (2005) The Dirty Dozen: 12 Myths That Undermine Tobacco Control. American Journal of Public Health 95:9, 1500-1505
    CrossRef

  189. 189

    Caryn Lerman, Christopher Jepson, E Paul Wileyto, Leonard H Epstein, Margaret Rukstalis, Freda Patterson, Vyga Kaufmann, Stephanie Restine, Larry Hawk, Ray Niaura, Wade Berrettini. (2005) Role of Functional Genetic Variation in the Dopamine D2 Receptor (DRD2) in Response to Bupropion and Nicotine Replacement Therapy for Tobacco Dependence: Results of Two Randomized Clinical Trials. Neuropsychopharmacology
    CrossRef

  190. 190

    B. L. W. BENDERMACHER, E. M. WILLIGENDAEL, J. A. W. TEIJINK, M. H. PRINS. (2005) Medical management of peripheral arterial disease. Journal of Thrombosis and Haemostasis 3:8, 1628-1637
    CrossRef

  191. 191

    Marc Mooney, David Babb, Joni Jensen, Dorothy Hatsukami. (2005) Interventions to increase use of nicotine gum: A randomized, controlled, single‐blind trial. Nicotine & Tobacco Research 7:4, 565-579
    CrossRef

  192. 192

    Joseph Biederman, Stephen V Faraone. (2005) Attention-deficit hyperactivity disorder. The Lancet 366:9481, 237-248
    CrossRef

  193. 193

    Jotham W. Coe, Michael G. Vetelino, Crystal G. Bashore, Michael C. Wirtz, Paige R. Brooks, Eric P. Arnold, Lorraine A. Lebel, Carol B. Fox, Steven B. Sands, Thomas I. Davis, David W. Schulz, Hans Rollema, F. David Tingley, Brian T. O’Neill. (2005) In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine. Bioorganic & Medicinal Chemistry Letters 15:12, 2974-2979
    CrossRef

  194. 194

    Joanne K. Singleton, Rona F. Levin, Harriet R. Feldman, Marie Truglio-Londrigan. (2005) Evidence for Smoking Cessation: Implications for Gender-Specific Strategies. Worldviews on Evidence-Based Nursing 2:2, 63-74
    CrossRef

  195. 195

    Margaret Rukstalis, Christopher Jepson, Andrew Strasser, Kevin G. Lynch, Kenneth Perkins, Freda Patterson, Caryn Lerman. (2005) Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigm. Psychopharmacology 180:1, 41-48
    CrossRef

  196. 196

    Marta Torrens, Francina Fonseca, Gerard Mateu, Magí Farré. (2005) Efficacy of antidepressants in substance use disorders with and without comorbid depression. Drug and Alcohol Dependence 78:1, 1-22
    CrossRef

  197. 197

    Joy M. Schmitz, Shelly L. Sayre, Angela L. Stotts, Jennifer Rothfleisch, Marc E. Mooney. (2005) Medication Compliance During a Smoking Cessation Clinical Trial: A Brief Intervention Using MEMS Feedback. Journal of Behavioral Medicine 28:2, 139-147
    CrossRef

  198. 198

    F. Lebargy, L.-A. Becquart, B. Picavet. (2005) Épidémiologie du tabagisme. Aide à l’arrêt du tabac. EMC - Médecine 2:2, 171-190
    CrossRef

  199. 199

    Timothy E. Wilens, Barbara R. Haight, Joseph P. Horrigan, James J. Hudziak, Norman E. Rosenthal, Daniel F. Connor, Kenneth D. Hampton, Nathalie E. Richard, Jack G. Modell. (2005) Bupropion XL in adults with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled study. Biological Psychiatry 57:7, 793-801
    CrossRef

  200. 200

    P. M. J. Puska, M. Barrueco, C. Roussos, A. Hider, S. Hogue. (2005) The participation of health professionals in a smoking-cessation programme positively influences the smoking cessation advice given to patients. International Journal of Clinical Practice 59:4, 447-452
    CrossRef

  201. 201

    Olga D. Taraschenko, Vishal Panchal, Isabelle M. Maisonneuve, Stanley D. Glick. (2005) Is antagonism of α3β4 nicotinic receptors a strategy to reduce morphine dependence?. European Journal of Pharmacology 513:3, 207-218
    CrossRef

  202. 202

    G. J. Johnson, J. Cosnes, J. C. Mansfield. (2005) Review article: smoking cessation as primary therapy to modify the course of Crohn's disease. Alimentary Pharmacology and Therapeutics 21:8, 921-931
    CrossRef

  203. 203

    E. J. Wagena, P. Knipschild, M. P. A. Zeegers. (2005) Should nortriptyline be used as a first-line aid to help smokers quit? Results from a systematic review and meta-analysis. Addiction 100:3, 317-326
    CrossRef

  204. 204

    Saman Warnakulasuriya, Gay Sutherland, Crispian Scully. (2005) Tobacco, oral cancer, and treatment of dependence. Oral Oncology 41:3, 244-260
    CrossRef

  205. 205

    Robert West, Peter Hajek, Lindsay Stead, John Stapleton. (2005) Outcome criteria in smoking cessation trials: proposal for a common standard. Addiction 100:3, 299-303
    CrossRef

  206. 206

    Mary T. Roth, Miranda R. Andrus, Eric C. Westman. (2005) Outcomes from an Outpatient Smoking-Cessation Clinic. Pharmacotherapy 25:2, 279-288
    CrossRef

  207. 207

    Dipesh Joshi, Pattipati S. Naidu, Amanpreet Singh, Shrinivas K. Kulkarni. (2005) Reversal of Triazolam Tolerance and Withdrawal-Induced Hyperlocomotor Activity and Anxiety by Bupropion in Mice. Pharmacology 75:2, 93-97
    CrossRef

  208. 208

    Paul M. Cinciripini, Janice Y. Tsoh, David W. Wetter, Cho Lam, Carl de Moor, Lynn Cinciripini, Walter Baile, Cheryl Anderson, John D. Minna. (2005) Combined effects of venlafaxine, nicotine replacement, and brief counseling on smoking cessation.. Experimental and Clinical Psychopharmacology 13:4, 282-292
    CrossRef

  209. 209

    Theodore V. Cooper, Robert C. Klesges, Margaret W. DeBon, Susan M. Zbikowski, Karen C. Johnson, Linda H. Clemens. (2005) A placebo controlled randomized trial of the effects of phenylpropanolamine and nicotine gum on cessation rates and postcessation weight gain in women. Addictive Behaviors 30:1, 61-75
    CrossRef

  210. 210

    Kathleen T. Brady, Marcia L. Verduin. (2005) Pharmacotherapy of Comorbid Mood, Anxiety, and Substance Use Disorders. Substance Use & Misuse 40:13-14, 2021-2041
    CrossRef

  211. 211

    Keigo Takagi, Nobuhide Kato, Syuichi Sasamoto, Yoshinobu Hata. (2005) Nicotine Replacement Therapy for Smoking Cessation. Nihon Kikan Shokudoka Gakkai Kaiho 56:5, 424-430
    CrossRef

  212. 212

    M SOFUOGLU, T KOSTEN. (2004) Pharmacologic management of relapse prevention in addictive disorders. Psychiatric Clinics of North America 27:4, 627-648
    CrossRef

  213. 213

    Helmut Niederhofer, Markus Huber. (2004) Bupropion May Support Psychosocial Treatment of Nicotine-Dependent Adolescents: Preliminary Results. Pharmacotherapy 24:11, 1524-1528
    CrossRef

  214. 214

    Aung Htoo, Arunabh Talwar, Steven H. Feinsilver, Harly Greenberg. (2004) Smoking and sleep disorders. Medical Clinics of North America 88:6, 1575-1591
    CrossRef

  215. 215

    Thomas R. Kosten, Therese A. Kosten. (2004) New medication strategies for comorbid substance use and bipolar affective disorders. Biological Psychiatry 56:10, 771-777
    CrossRef

  216. 216

    Deborah Scharf, Saul Shiffman. (2004) Are there gender differences in smoking cessation, with and without bupropion? Pooled- and meta-analyses of clinical trials of Bupropion SR. Addiction 99:11, 1462-1469
    CrossRef

  217. 217

    Andy McEwen, Robert West, Lesley Owen. (2004) GP prescribing of nicotine replacement and bupropion to aid smoking cessation in England and Wales. Addiction 99:11, 1470-1474
    CrossRef

  218. 218

    Arunabh Talwar, Mukesh Jain, V.K. Vijayan. (2004) Pharmacotherapy of tobacco dependence. Medical Clinics of North America 88:6, 1517-1534
    CrossRef

  219. 219

    JR Hughes, LF Stead, T Lancaster, John Hughes. 2004. Antidepressants for smoking cessation. .
    CrossRef

  220. 220

    Harold S. Javitz, Gary E. Swan, Susan M. Zbikowski, Susan J. Curry, Timothy A. McAfee, Donna Decker, Richard Patterson, Lisa M. Jack. (2004) Return on Investment of Different Combinations of Bupropion SR Dose and Behavioral Treatment for Smoking Cessation in a Health Care Setting: An Employer's Perspective. Value in Health 7:5, 535-543
    CrossRef

  221. 221

    H. J. Aubin, F. Lebargy, I. Berlin, C. Bidaut-Mazel, J. Chemali-Hudry, G. Lagrue. (2004) Efficacy of bupropion and predictors of successful outcome in a sample of French smokers: a randomized placebo-controlled trial. Addiction 99:9, 1206-1218
    CrossRef

  222. 222

    Katherine A DeLaune, Joy M Schmitz. (2004) Treatment of Nicotine Addiction. Addictive Disorders & Their Treatment 3:3, 97-109
    CrossRef

  223. 223

    Renato P Munhoz. (2004) Serotonin Syndrome Induced by a Combination of Bupropion and SSRIs. Clinical Neuropharmacology 27:5, 219-222
    CrossRef

  224. 224

    Jos?? Mart??nez-Raga, Ana Sabater, Gaspar Cervera. (2004) Anorgasmia in a Patient Treated With Bupropion SR for Smoking Cessation. Journal of Clinical Psychopharmacology 24:4, 460-461
    CrossRef

  225. 225

    Stephen I Rennard. (2004) Treatment of stable chronic obstructive pulmonary disease. The Lancet 364:9436, 791-802
    CrossRef

  226. 226

    J Lee Westmaas, Thomas H Brandon. (2004) Reducing risk in smokers. Current Opinion in Pulmonary Medicine 10:4, 284-288
    CrossRef

  227. 227

    José Miguel Chatkin, Carolina Mariante de Abreu, Fábio Maraschin Haggsträm, Mário Bernardes Wagner, Carlos Cezar Fritscher. (2004) Abstinence rates and predictors of outcome for smoking cessation: do Brazilian smokers need special strategies?. Addiction 99:6, 778-784
    CrossRef

  228. 228

    C. Filozof, M. C. Fernandez Pinilla, A. Fernandez-Cruz. (2004) Smoking cessation and weight gain. Obesity Reviews 5:2, 95-103
    CrossRef

  229. 229

    R. A. Schnoll, P. F. Engstrom. (2004) Tobacco Control in the Physician's Office: A Matter of Adequate Training and Resources. JNCI Journal of the National Cancer Institute 96:8, 573-575
    CrossRef

  230. 230

    Arthur L. Brody, Mark A. Mandelkern, Grace Lee, Erlyn Smith, Mary Sadeghi, Sanjaya Saxena, Murray E. Jarvik, Edythe D. London. (2004) Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Research: Neuroimaging 130:3, 269-281
    CrossRef

  231. 231

    Bo S. Wong, John Fraser. (2004) The use of Bupropion for Smoking Cessation in Rural New South Wales. Australian Journal of Rural Health 12:2, 38-39
    CrossRef

  232. 232

    Linda P Dwoskin, Sangeetha P Sumithran, Jun Zhu, A.Gabriela Deaciuc, Joshua T Ayers, Peter A Crooks. (2004) Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents. Bioorganic & Medicinal Chemistry Letters 14:8, 1863-1867
    CrossRef

  233. 233

    Wallace B Pickworth, Eun M Lee, Mary E Abreu, Annie Umbricht, Kenzie L Preston. (2004) A laboratory study of hydromorphone and cyclazocine on smoking behavior in residential polydrug users. Pharmacology Biochemistry and Behavior 77:4, 711-715
    CrossRef

  234. 234

    Kari Jo Harris, Kolawole S Okuyemi, Delwyn Catley, Matthew S Mayo, Bin Ge, Jasjit S Ahluwalia. (2004) Predictors of smoking cessation among African-Americans enrolled in a randomized controlled trial of bupropion. Preventive Medicine 38:4, 498-502
    CrossRef

  235. 235

    Serena Tonstad, J Andrew Johnston. (2004) Does bupropion have advantages over other medical therapies in the cessation of smoking?. Expert Opinion on Pharmacotherapy 5:4, 727-734
    CrossRef

  236. 236

    Debra J. Romberger, Kathleen Grant. (2004) Alcohol consumption and smoking status: the role of smoking cessation. Biomedicine & Pharmacotherapy 58:2, 77-83
    CrossRef

  237. 237

    S. Holmes, N. Zwar, C.A. Jiménez-Ruiz, P.J. Ryan, D. Browning, L. Bergmann, J.A. Johnston. (2004) Bupropion as an aid to smoking cessation: a review of real-life effectiveness. International Journal of Clinical Practice 58:3, 285-291
    CrossRef

  238. 238

    Belinda Borrelli, George Papandonatos, Bonnie Spring, Brian Hitsman, Raymond Niaura. (2004) Experimenter-defined quit dates for smoking cessation: adherence improves outcomes for women but not for men. Addiction 99:3, 378-385
    CrossRef

  239. 239

    HIMANSHU P. UPADHYAYA, KATHLEEN T. BRADY, WEI WANG. (2004) Bupropion SR in Adolescents With Comorbid ADHD and Nicotine Dependence: A Pilot Study. Journal of the American Academy of Child & Adolescent Psychiatry 43:2, 199-205
    CrossRef

  240. 240

    Gary E. Swan, Harold S. Javitz, Lisa M. Jack, Susan J. Curry, Tim McAfee. (2004) Heterogeneity in 12-month outcome among female and male smokers. Addiction 99:2, 237-250
    CrossRef

  241. 241

    Georgia K. Johnson, Margaret Hill. (2004) Cigarette Smoking and the Periodontal Patient. Journal of Periodontology 75:2, 196-209
    CrossRef

  242. 242

    Kay Wilhelm, Kay Wilhelm, Karen Arnold, Heather Niven, Robyn Richmond. (2004) Grey lungs and blue moods: smoking cessation in the context of lifetime depression history. Australian and New Zealand Journal of Psychiatry 38:11-12, 896-905
    CrossRef

  243. 243

    Caryn Lerman, Ray Niaura, Bradley N. Collins, Paul Wileyto, Janet Audrain-McGovern, Angela Pinto, Larry Hawk, Leonard H. Epstein. (2004) Effect of Bupropion on Depression Symptoms in a Smoking Cessation Clinical Trial.. Psychology of Addictive Behaviors 18:4, 362-366
    CrossRef

  244. 244

    Bonnie Spring, Neal Doran, Sherry Pagoto, Kristin Schneider, Regina Pingitore, Don Hedeker. (2004) Randomized Controlled Trial for Behavioral Smoking and Weight Control Treatment: Effect of Concurrent Versus Sequential Intervention.. Journal of Consulting and Clinical Psychology 72:5, 785-796
    CrossRef

  245. 245

    Marie France Lan Cheong Wah, Lan Sem Hing Lan Cheong Wah. (2004) Generalized Seizure in a Mauritian Woman Taking Bupropion. PLoS Medicine 1:1, e15
    CrossRef

  246. 246

    Judith J. Prochaska, Kevin Delucchi, Sharon M. Hall. (2004) A Meta-Analysis of Smoking Cessation Interventions With Individuals in Substance Abuse Treatment or Recovery.. Journal of Consulting and Clinical Psychology 72:6, 1144-1156
    CrossRef

  247. 247

    Joel D. Killen, Thomas N. Robinson, Seth Ammerman, Chris Hayward, Jayna Rogers, Christi Stone, Deanne Samuels, Sara K. Levin, Sarah Green, Alan F. Schatzberg. (2004) Randomized Clinical Trial of the Efficacy of Bupropion Combined With Nicotine Patch in the Treatment of Adolescent Smokers.. Journal of Consulting and Clinical Psychology 72:4, 729-735
    CrossRef

  248. 248

    Tony P George, Stephanie S O'Malley. (2004) Current pharmacological treatments for nicotine dependence. Trends in Pharmacological Sciences 25:1, 42-48
    CrossRef

  249. 249

    Stephan Muehlig, Eva Hoch, Michael Hoefler, David Pittrow, Hans-Ulrich Wittchen. (2003) Aims, design and methods of the Smoking and Nicotine Dependence Awareness and Screening (SNICAS) study. International Journal of Methods in Psychiatric Research 12:4, 208-228
    CrossRef

  250. 250

    Peter Hajek, Fiona Gillison, Hayden McRobbie. (2003) Stopping smoking can cause constipation. Addiction 98:11, 1563-1567
    CrossRef

  251. 251

    Elbert D. Glover, Penny N. Glover, Thomas J. Payne. (2003) Treating Nicotine Dependence. The American Journal of the Medical Sciences 326:4, 183-186
    CrossRef

  252. 252

    L. Susan Buttross, Joseph W. Kastner. (2003) A Brief Review of Adolescents and Tobacco: What We Know and Don???t Know. The American Journal of the Medical Sciences 326:4, 235-237
    CrossRef

  253. 253

    Susan M Learned-Coughlin, Mats Bergström, Irina Savitcheva, John Ascher, Virginia D Schmith, Bengt Långstrom. (2003) In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography. Biological Psychiatry 54:8, 800-805
    CrossRef

  254. 254

    Adrie W. Bruijnzeel, Athina Markou. (2003) Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats. Synapse 50:1, 20-28
    CrossRef

  255. 255

    Ashwin A. Patkar, Michael J. Vergare, Vikas Batra, Steven P. Weinstein, Frank T. Leone. (2003) Tobacco Smoking: Current Concepts in Etiology and Treatment. Psychiatry: Interpersonal and Biological Processes 66:3, 183-199
    CrossRef

  256. 256

    P. Tonnesen, S. Tonstad, A. Hjalmarson, F. Lebargy, P. I. van Spiegel, A. Hider, R. Sweet, J. Townsend. (2003) A multicentre, randomized, double-blind, placebo-controlled, 1-year study of bupropion SR for smoking cessation. Journal of Internal Medicine 254:2, 184-192
    CrossRef

  257. 257

    Lisa Sanderson Cox, Nicole L. Africano, Kenneth P. Tercyak, Kathryn L. Taylor. (2003) Nicotine dependence treatment for patients with cancer. Cancer 98:3, 632-644
    CrossRef

  258. 258

    J. Taylor Hays, Jon O. Ebbert. (2003) Bupropion Sustained Release for Treatment of Tobacco Dependence. Mayo Clinic Proceedings 78:8, 1020-1024
    CrossRef

  259. 259

    J. T. Hays, J. O. Ebbert. (2003) Bupropion Sustained Release for Treatment of Tobacco Dependence. Mayo Clinic Proceedings 78:8, 1020-1024
    CrossRef

  260. 260

    Margaret Miller, Lisa Wood. (2003) Effectiveness of smoking cessation interventions: review of evidence and implications for best practice in Australian health care settings. Australian and New Zealand Journal of Public Health 27:3, 300-309
    CrossRef

  261. 261

    Edward M. Sellers, Rachel F. Tyndale, Leona C. Fernandes. (2003) Decreasing smoking behaviour and risk through CYP2A6 inhibition. Drug Discovery Today 8:11, 487-493
    CrossRef

  262. 262

    Lisa M Jack, Gary E Swan, Ella Thompson, Susan J Curry, Timothy McAfee, Sara Dacey, Katherine Bergman. (2003) Bupropion SR and smoking cessation in actual practice: methods for recruitment, screening, and exclusion for a field trial in a managed-care settingResearch supported by Grant CA71358 from the National Cancer Institute to SRI International. Bupropion SR provided by Group Health Cooperative Pharmacy.. Preventive Medicine 36:5, 585-593
    CrossRef

  263. 263

    Sean M. Bagshaw, Bruce Cload, Janet Gilmour, Stephen T. Leung, Thomas J. Bowen. (2003) Drug-induced rash with eosinophilia and systemic symptoms syndrome with bupropion administration. Annals of Allergy, Asthma & Immunology 90:5, 572-575
    CrossRef

  264. 264

    Gary E. Swan, Karen S. Hudmon, Taline V. Khroyan. 2003. Tobacco Dependence. .
    CrossRef

  265. 265

    Robert West. (2003) Bupropion SR for smoking cessation. Expert Opinion on Pharmacotherapy 4:4, 533-540
    CrossRef

  266. 266

    Bodo Cremers, Kathrin I. Schmidt, Christoph Maack, Hans-Joachim Schäfers, Michael Böhm. (2003) Catecholamine release in human heart by bupropion. European Journal of Pharmacology 467:1-3, 169-171
    CrossRef

  267. 267

    Himanshu P. Upadhyaya, Kathleen T. Brady, Mollie Wharton, Jason Liao. (2003) Psychiatric Disorders and Cigarette Smoking Among Child and Adolescent Psychiatry Inpatients. The American Journal on Addictions 12:2, 144-152
    CrossRef

  268. 268

    JOSÉ MARTÍNEZ-RAGA, FRANCIS KEANEY, GAY SUTHERLAND, BARTOLOME PEREZ-GALVEZ, JOHN STRANG. (2003) Treatment of nicotine dependence with bupropion SR: review of its efficacy, safety and pharmacological profile. Addiction Biology 8:1, 13-21
    CrossRef

  269. 269

    Rohit Ahuja, Sandra B. Weibel, Frank T. Leone. (2003) Lung cancer: The oncologist's role in smoking cessation. Seminars in Oncology 30:1, 94-103
    CrossRef

  270. 270

    Leslie Iversen, Richard A. Glennon. 2003. Antidepressants. .
    CrossRef

  271. 271

    Tony P George, Jennifer C Vessicchio, Angelo Termine, Peter I Jatlow, Thomas R Kosten, Stephanie S O’Malley. (2003) A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation. Biological Psychiatry 53:2, 136-143
    CrossRef

  272. 272

    Thomas M. Piasecki, Douglas E. Jorenby, Stevens S. Smith, Michael C. Fiore, Timothy B. Baker. (2003) Smoking Withdrawal Dynamics: III. Correlates of Withdrawal Heterogeneity.. Experimental and Clinical Psychopharmacology 11:4, 276-285
    CrossRef

  273. 273

    PATTI URSO. (2003) Match the best smoking cessation intervention to your patient. Clinical Nurse Specialist12-16,18-19,21
    CrossRef

  274. 274

    J. Taylor Hays, Jon O. Ebbert. (2003) Bupropion for the Treatment of Tobacco Dependence. CNS Drugs 17:2, 71-83
    CrossRef

  275. 275

    W Burleson Daviss, Raymond J Pan, James M Perel. (2003) Bupropion for attentiondeficit hyperactivity and comorbid disorders. Expert Review of Neurotherapeutics 3:1, 9-18
    CrossRef

  276. 276

    Anne M Joseph, Steven S Fu. (2003) Smoking Cessation for Patients with Cardiovascular Disease. American Journal of Cardiovascular Drugs 3:5, 339-349
    CrossRef

  277. 277

    Chin K Kim, Carsten M Schmalfuss, Richard S Schofield, David S Sheps. (2003) Pharmacological Treatment of Patients with Peripheral Arterial Disease. Drugs 63:7, 637-647
    CrossRef

  278. 278

    Caryn Lerman, Peter G. Shields, E. Paul Wileyto, Janet Audrain, Larry H., Jr. Hawk, Angela Pinto, Susan Kucharski, Shiva Krishnan, Ray Niaura, Leonard H. Epstein. (2003) Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial.. Health Psychology 22:5, 541-548
    CrossRef

  279. 279

    S. Fays, P. Trechot, J.L. Schmutz, J.F. Cuny, F. Truchetet, A. Barbaud. (2003) Bupropion and generalized acute urticaria: eight cases. British Journal of Dermatology 148:1, 177-178
    CrossRef

  280. 280

    Edwin J Wagena, Maurice P A Zeegers, Constant P van Schayck, Emiel F M Wouters. (2003) Benefits and Risks of Pharmacological Smoking Cessation Therapies in Chronic Obstructive Pulmonary Disease. Drug Safety 26:6, 381-403
    CrossRef

  281. 281

    PATTI URSO. (2003) Match the best smoking cessation intervention to your patient. The Nurse Practitioner 28:Supp: 2003, 12-16,18-19,21
    CrossRef

  282. 282

    Richard D. Hurt. (2002) Pharmacotherapy for Alcoholic Smokers. Alcoholism: Clinical and Experimental Research 26:12, 1939-1941
    CrossRef

  283. 283

    Joseph A Tracey. (2002) Zyban ® – is there a cause for concern?. Expert Opinion on Drug Safety 1:4, 303-305
    CrossRef

  284. 284

    Caryn Lerman, Peter G Shields, E Paul Wileyto, Janet Audrain, Angela Pinto, Larry Hawk, Shiva Krishnan, Ray Niaura, Leonard Epstein. (2002) Pharmacogenetic investigation of smoking cessation treatment. Pharmacogenetics 12:8, 627-634
    CrossRef

  285. 285

    R. S. Kahn, L. Certain, R. C. Whitaker. (2002) A Reexamination of Smoking Before, During, and After Pregnancy. American Journal of Public Health 92:11, 1801-1808
    CrossRef

  286. 286

    Ivan Berlin, Henri-Jean Aubin, Anne-Marie Pedarriosse, Alexis Rames, , Sylvie Lancrenon, Gilbert Lagrue. (2002) Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation. Addiction 97:10, 1347-1354
    CrossRef

  287. 287

    Tony P George, Jennifer C Vessicchio, Angelo Termine, Thomas A Bregartner, Alan Feingold, Bruce J Rounsaville, Thomas R Kosten. (2002) A placebo controlled trial of bupropion for smoking cessation in schizophrenia. Biological Psychiatry 52:1, 53-61
    CrossRef

  288. 288

    Caryn Lerman, David Roth, Vyga Kaufmann, Janet Audrain, Larry Hawk, Aiyi Liu, Ray Niaura, Leonard Epstein. (2002) Mediating mechanisms for the impact of bupropion in smoking cessation treatment. Drug and Alcohol Dependence 67:2, 219-223
    CrossRef

  289. 289

    Richard D. Hurt, Troy D. Wolter, Nancy Rigotti, J.Taylor Hays, Raymond Niaura, Michael J. Durcan, David Gonzales, David P.L. Sachs, J.Andrew Johnston, Kenneth P. Offord. (2002) Bupropion for pharmacologic relapse prevention to smoking. Addictive Behaviors 27:4, 493-507
    CrossRef

  290. 290

    N.H. Cox, P.M. Gordon, H. Dodd. (2002) Generalized pustular and erythrodermic psoriasis associated with bupropion treatment. British Journal of Dermatology 146:6, 1061-1063
    CrossRef

  291. 291

    Richard Young, Richard A. Glennon. (2002) Nicotine and bupropion share a similar discriminative stimulus effect. European Journal of Pharmacology 443:1-3, 113-118
    CrossRef

  292. 292

    Alan Cheng, Joel B. Braunstein, Cheryl Dennison, Caitlin Nass, Roger S. Blumenthal. (2002) Reducing global risk for cardiovascular disease: Using lifestyle changes and pharmacotherapy. Clinical Cardiology 25:5, 205-212
    CrossRef

  293. 293

    Michael J. Durcan, Greg Deener, Jonathan White, J.Andrew Johnston, David Gonzales, Raymond Niaura, Nancy Rigotti, David P.L. Sachs. (2002) The effect of bupropion sustained-release on cigarette craving after smoking cessation. Clinical Therapeutics 24:4, 540-551
    CrossRef

  294. 294

    Pallab Seth, Survjit Cheeta, Sonia Tucci, Sandra E. File. (2002) Nicotinic–serotonergic interactions in brain and behaviour. Pharmacology Biochemistry and Behavior 71:4, 795-805
    CrossRef

  295. 295

    Sharon L. Collins. (2002) Current strategies for cessation of smoking for head and neck cancer patients. Current Opinion in Otolaryngology & Head and Neck Surgery 10:2, 69-79
    CrossRef

  296. 296

    Richard D Hurt, Jon O Ebbert. (2002) Preventing lung cancer by stopping smoking. Clinics in Chest Medicine 23:1, 27-36
    CrossRef

  297. 297

    Rigotti, Nancy A., . (2002) Treatment of Tobacco Use and Dependence. New England Journal of Medicine 346:7, 506-512
    Full Text

  298. 298

    R. Donnelly, J.M.C. Yeung. (2002) Management of Intermittent Claudication: the Importance of Secondary Prevention. European Journal of Vascular and Endovascular Surgery 23:2, 100-107
    CrossRef

  299. 299

    Andrew J. Johnston, John Ascher, Robert Leadbetter, Virginia D. Schmith, Dipak K. Patel, Michael Durcan, Beth Bentley. (2002) Pharmacokinetic Optimisation of Sustained-Release Bupropion for Smoking Cessation. Drugs 62:Supplement 2, 11-24
    CrossRef

  300. 300

    Rod J. Rohrich, Dana M. Coberly, Jeffery K. Krueger, and Spencer A. Brown. (2002) Planning Elective Operations on Patients Who Smoke: Survey of North American Plastic Surgeons. Plastic and Reconstructive Surgery 109:1, 350-355
    CrossRef

  301. 301

    Douglas Jorenby. (2002) Clinical Efficacy of Bupropion in the Management of Smoking Cessation. Drugs 62:Supplement 2, 25-35
    CrossRef

  302. 302

    Raymond Niaura, David B. Abrams. (2002) Smoking cessation: Progress, priorities, and prospectus.. Journal of Consulting and Clinical Psychology 70:3, 494-509
    CrossRef

  303. 303

    Henri-Jean Aubin. (2002) Tolerability and Safety of Sustained-Release Bupropion in the Management of Smoking Cessation. Drugs 62:Supplement 2, 45-52
    CrossRef

  304. 304

    Gay Sutherland. (2002) Current Approaches to the Management of Smoking Cessation. Drugs 62:Supplement 2, 53-61
    CrossRef

  305. 305

    David C. Henderson. (2002) Atypical Antipsychotic???Induced Diabetes Mellitus. CNS Drugs 16:2, 77-89
    CrossRef

  306. 306

    Serena Tonstad. (2002) Use of Sustained-Release Bupropion in Specific Patient Populations for Smoking Cessation. Drugs 62:Supplement 2, 37-43
    CrossRef

  307. 307

    Raymond Niaura, Bonnie Spring, Belinda Borrelli, Donald Hedeker, Michael G. Goldstein, Nancy Keuthen, Judy DePue, Jean Kristeller, Judy Ockene, Allan Prochazka, John A. Chiles, David B. Abrams. (2002) Multicenter trial of fluoxetine as an adjunct to behavioral smoking cessation treatment.. Journal of Consulting and Clinical Psychology 70:4, 887-896
    CrossRef

  308. 308

    Elaine C Johnstone, Emma E York, Robert T Walton. (2002) Genetic testing: the future of smoking cessation therapy?. Expert Review of Molecular Diagnostics 2:1, 60-68
    CrossRef

  309. 309

    Richard D. Hurt. (2002) Pharmacotherapy for Alcoholic Smokers. Alcoholism: Clinical and Experimental Research 26:12, 1939
    CrossRef

  310. 310

    James H. Stein, Magda Bushara, Khalaf Bushara, Patrick E. McBride, Douglas E. Jorenby, Michael C. Fiore. (2002) Smoking cessation, but not smoking reduction, reduces plasma homocysteine levels. Clinical Cardiology 25:1, 23-26
    CrossRef

  311. 311

    Tomas Palomo, Trevor Archer, Richard J. Beninger, Richard M. Kostrzewa. (2002) Neurodevelopmental liabilities of substance abuse. Neurotoxicity Research 4:4, 267-279
    CrossRef

  312. 312

    Athina Markou, Paul J. Kenny. (2002) Neuroadaptations to chronic exposure to drugs of abuse: Relevance to depressive symptomatology seen across psychiatric diagnostic categories. Neurotoxicity Research 4:4, 297-313
    CrossRef

  313. 313

    Michael Kotlyar, Michael Golding, Dorothy K. Hatsukami, Brenda D. Jamerson. (2001) Effect of Nonnicotine Pharmacotherapy on Smoking Behavior. Pharmacotherapy 21:12, 1530-1548
    CrossRef

  314. 314

    Jennifer O'Loughlin, Héla Makni, Michèle Tremblay, Chantal Lacroix, André Gervais, Véronique Déry, Garbis Meshefedjian, Gilles Paradis. (2001) Smoking Cessation Counseling Practices of General Practitioners in Montreal. Preventive Medicine 33:6, 627-638
    CrossRef

  315. 315

    Jamie S. Ostroff, Natasha Buckshee, Carol A. Mancuso, David F. Yankelevitz, Claudia I. Henschke. (2001) Smoking Cessation Following CT Screening for Early Detection of Lung Cancer. Preventive Medicine 33:6, 613-621
    CrossRef

  316. 316

    Catherine A. Fleming, Henri U. Balaguera, Donald E. Craven. (2001) RISK FACTORS FOR NOSOCOMIAL PNEUMONIA. Medical Clinics of North America 85:6, 1545-1563
    CrossRef

  317. 317

    William H. Frishman, Tom Ky, Anjum Ismail. (2001) Tobacco Smoking, Nicotine, and Nicotine and Non-Nicotine Replacement Therapies. Heart Disease365-377
    CrossRef

  318. 318

    IA Campbell. (2001) Safety profile of bupropion for chronic obstructive pulmonary disease. The Lancet 358:9286, 1010
    CrossRef

  319. 319

    Jeffery K. Krueger, Rodney J. Rohrich. (2001) Clearing the Smoke: The Scientific Rationale for Tobacco Abstention with Plastic Surgery. Plastic and Reconstructive Surgery 108:4, 1063-1073
    CrossRef

  320. 320

    Harri Vainio, Elisabete Weiderpass, Paul Kleihues. (2001) Smoking cessation in cancer prevention. Toxicology 166:1-2, 47-52
    CrossRef

  321. 321

    T. Lancaster, L. Stead, S. Shepperd. (2001) Helping parents to stop smoking: which interventions are effective?. Paediatric Respiratory Reviews 2:3, 222-226
    CrossRef

  322. 322

    Francisco García-Río, Soledad Serrano, Olga Mediano, Alberto Alonso, Jose Villamor. (2001) Safety profile of bupropion for chronic obstructive pulmonary disease. The Lancet 358:9286, 1009
    CrossRef

  323. 323

    Anne M. Joseph, Lawrence C. An. (2001) Tobacco smoking in patients with cardiovascular disease. Current Treatment Options in Cardiovascular Medicine 3:4, 313-322
    CrossRef

  324. 324

    Inder Mainie, Colm McGurk, Gavin McClintock, J Robinson. (2001) Seizures after buproprion overdose. The Lancet 357:9268, 1624
    CrossRef

  325. 325

    Aimee L. McRae, Kathleen T. Brady, Susan C. Sonne. (2001) ALCOHOL AND SUBSTANCE ABUSE. Medical Clinics of North America 85:3, 779-801
    CrossRef

  326. 326

    Mary T. Roth, Eric C. Westman. (2001) Use of Bupropion SR in a Pharmacist-Managed Outpatient Smoking-Cessation Program. Pharmacotherapy 21:5, 636-641
    CrossRef

  327. 327

    DP Tashkin, R Kanner, W Bailey, S Buist, P Anderson, MA Nides, D Gonzales, G Dozier, MK Patel, BD Jamerson. (2001) Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial. The Lancet 357:9268, 1571-1575
    CrossRef

  328. 328

    B Jamerson. (2001) Late-term smoking cessation despite initial failure: an evaluation of bupropion sustained release, nicotine patch, combination therapy, and placebo. Clinical Therapeutics 23:5, 744-752
    CrossRef

  329. 329

    I. Hindmarch. (2001) Expanding the horizons of depression: beyond the monoamine hypothesis. Human Psychopharmacology: Clinical and Experimental 16:3, 203-218
    CrossRef

  330. 330

    &NA;. (2001) Non-nicotine pharmacotherapy may prove useful in smoking cessation. Drugs & Therapy Perspectives 17:5, 9-12
    CrossRef

  331. 331

    Michael A. Hertzberg, Scott D. Moore, Michelle E. Feldman, Jean C. Beckham. (2001) A Preliminary Study of Bupropion Sustained-Release for Smoking Cessation in Patients With Chronic Posttraumatic Stress Disorder. Journal of Clinical Psychopharmacology 21:1, 94-98
    CrossRef

  332. 332

    Brian Hitsman, Bonnie Spring, Belinda Borrelli, Raymond Niaura, George D. Papandonatos. (2001) Influence of antidepressant pharmacotherapy on behavioral treatment adherence and smoking cessation outcome in a combined treatment involving fluoxetine.. Experimental and Clinical Psychopharmacology 9:4, 355-362
    CrossRef

  333. 333

    CHRISTOPHER J. WELSH, JOSEPH LIBERTO. (2001) The Use of Medication for Relapse Prevention in Substance Dependence Disorders. Journal of Psychiatric Practice 7:1, 15-31
    CrossRef

  334. 334

    H. de Vries. 2001. Smoking Prevention and Smoking Cessation. , 14201-14205.
    CrossRef

  335. 335

    Steven S. Smith, Douglas E. Jorenby, Michael C. Fiore, Jane E. Anderson, Michelle M. Mielke, Kirstin E. Beach, Thomas M. Piasecki, Timothy B. Baker. (2001) Strike while the iron is hot: Can stepped-care treatments resurrect relapsing smokers?. Journal of Consulting and Clinical Psychology 69:3, 429-439
    CrossRef

  336. 336

    Kenneth A. Perkins. (2001) Smoking Cessation in Women. CNS Drugs 15:5, 391-411
    CrossRef

  337. 337

    Kenneth A. Perkins, Marsha D. Marcus, Michele D. Levine, Delia D'Amico, Amy Miller, Michelle Broge, Jacquelyn Ashcom, Saul Shiffman. (2001) Cognitive-behavioral therapy to reduce weight concerns improves smoking cessation outcome in weight-concerned women.. Journal of Consulting and Clinical Psychology 69:4, 604-613
    CrossRef

  338. 338

    Whooley, Mary A., Simon, Gregory E., . (2000) Managing Depression in Medical Outpatients. New England Journal of Medicine 343:26, 1942-1950
    Full Text

  339. 339

    Gary T. Ferguson. (2000) Update on Pharmacologic Therapy for Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 21:4, 723-738
    CrossRef

  340. 340

    M N Pemberton, G J Atherton, M H Thornhill. (2000) Personal view: Violence and aggression at work. British Dental Journal 189:8, 409-410
    CrossRef

  341. 341

    R S Levine. (2000) Smoking cessation: Briefing paper – Zyban. British Dental Journal 189:8, 412-412
    CrossRef

  342. 342

    Karen Ahijevych, Ruth Yerardl, Nancy Nedilsky. (2000) Descriptive outcomes of the american lung association of ohio hypnotherapy smoking cessation program. International Journal of Clinical and Experimental Hypnosis 48:4, 374-387
    CrossRef

  343. 343

    James C. McElnay, Terry A. Maguire, Ashlinn Drummond, Carmel M. Hughes. (2000) Smoking Cessation. Disease Management and Health Outcomes 8:3, 147-158
    CrossRef

  344. 344

    P. Tønnesen. (2000) Treatment of nicotine dependency with bupropion. European Neuropsychopharmacology 10, 120-121
    CrossRef

  345. 345

    Eoin McKinney, Robert Walton, Patricia Yudkin, Alice Fuller, Neil Haldar, David Mant, Mike Murphy, Ken Welsh, Sara Marshall. (2000) Pharmacogenetics 10:6, 483-491
    CrossRef

  346. 346

    Nancy A. Rigotti, Julia H. Arnsten, Kathleen M. McKool, Kristen M. Wood-Reid, Richard C. Pasternak, Daniel E. Singer. (2000) Smoking by Patients in a Smoke-Free Hospital: Prevalence, Predictors, and Implications. Preventive Medicine 31:2, 159-166
    CrossRef

  347. 347

    F López-Jiménez. (2000) Update in Internal Medicine. Archives of Medical Research 31:4, 329-352
    CrossRef

  348. 348

    J. Taylor Hays. (2000) Tobacco Dependence Treatment in Patients With Heart and Lung Disease: Implications for Intervention and Review of Pharmacological Therapy. Journal of Cardiopulmonary Rehabilitation 20:4, 215-223
    CrossRef

  349. 349

    Peter G. Shields. (2000) Epidemiology of tobacco carcinogenesis. Current Oncology Reports 2:3, 257-262
    CrossRef

  350. 350

    ERIC T. MOOLCHAN, MONIQUE ERNST, JACK E. HENNINGFIELD. (2000) A Review of Tobacco Smoking in Adolescents: Treatment Implications. Journal of the American Academy of Child & Adolescent Psychiatry 39:6, 682-693
    CrossRef

  351. 351

    Cynthia S Pomerleau, Ovide F Pomerleau, Rebecca J Namenek, Ann M Mehringer. (2000) Short-term weight gain in abstaining women smokers. Journal of Substance Abuse Treatment 18:4, 339-342
    CrossRef

  352. 352

    Neal L. Benowitz, Margaret Wilson Peng. (2000) Non-Nicotine Pharmacotherapy for Smoking Cessation. CNS Drugs 13:4, 265-285
    CrossRef

  353. 353

    Kristin J. Holm, Caroline M. Spencer. (2000) Bupropion. Drugs 59:4, 1007-1024
    CrossRef

  354. 354

    Glen A. Lillington, Colm T. Leonard, David P.L. Sachs. (2000) SMOKING CESSATION. Clinics in Chest Medicine 21:1, 199-208
    CrossRef

  355. 355

    Robert J. Hilsden, David C. Hodgins, Antje Timmer, Lloyd R. Sutherland. (2000) Clinical Reviews. Helping patients with Crohn's disease quit smoking. The American Journal of Gastroenterology 95:2, 352-358
    CrossRef

  356. 356

    Rajendra H. Mehta, Eduardo Bossone, Kim A. Eagle. (2000) Current concepts in secondary prevention after acute myocardial infarction. Herz 25:1, 47-60
    CrossRef

  357. 357

    Lirio S. Covey, Maria A. Sullivan, J. Andrew Johnston, Alexander H. Glassman, Mark D. Robinson, David P. Adams. (2000) Advances in Non-Nicotine Pharmacotherapy for Smoking Cessation. Drugs 59:1, 17-31
    CrossRef

  358. 358

    Hazel M. Gilbert, David M. Warburton. (2000) Craving: A Problematic Concept in Smoking Research. Addiction Research & Theory 8:4, 381-397
    CrossRef

  359. 359

    Joel D. Killen, Stephen P. Fortmann, Alan F. Schatzberg, Chris Hayward, Lisa Sussman, Micol Rothman, Laura Strausberg, Ann Varady. (2000) Nicotine patch and paroxetine for smoking cessation.. Journal of Consulting and Clinical Psychology 68:5, 883-889
    CrossRef

  360. 360

    Trevor T Hansel, Maggie J Leckie, Shannon A Bryan, Peter J Barnes. (2000) Novel therapy for COPD. Expert Opinion on Investigational Drugs 9:1, 3-23
    CrossRef

  361. 361

    Richard E. Wilcox, Carlton K. Erickson. (2000) Neurobiological Aspects of Addictions. Journal of Addictions Nursing 12:3-4, 117-132
    CrossRef

  362. 362

    Michael G. Goldstein, Raymond Niaura. (2000) METHODS TO ENHANCE SMOKING CESSATION AFTER MYOCARDIAL INFARCTION. Medical Clinics of North America 84:1, 63-80
    CrossRef

  363. 363

    Veljko J Djurić, Edward Dunn, David H Overstreet, Alina Dragomir, Meir Steiner. (1999) Antidepressant Effect of Ingested Nicotine in Female Rats of Flinders Resistant and Sensitive Lines. Physiology & Behavior 67:4, 533-537
    CrossRef

  364. 364

    Kim A. Eagle, Robert A. Guyton, Ravin Davidoff, Gordon A. Ewy, James Fonger, Timothy J. Gardner, John Parker Gott, Howard C. Herrmann, Robert A. Marlow, William C. Nugent, Gerald T. O’Connor, Thomas A. Orszulak, Richard E. Rieselbach, William L. Winters, Salim Yusuf, Raymond J. Gibbons, Joseph S. Alpert, Kim A. Eagle, Timothy J. Gardner, Arthur Garson, Gabriel Gregoratos, Richard O. Russell, Sidney C. Smith. (1999) ACC/AHA guidelines for coronary artery bypass graft surgery. Journal of the American College of Cardiology 34:4, 1262-1347
    CrossRef

  365. 365

    Thomas J Ryan, Elliott M Antman, Neil H Brooks, Robert M Califf, L.David Hillis, Loren F Hiratzka, Elliot Rapaport, Barbara Riegel, Richard O Russell, Earl E Smith, W.Douglas Weaver, Raymond J Gibbons, Joseph S Alpert, Kim A Eagle, Timothy J Gardner, Arthur Garson, Gabriel Gregoratos, Richard O Russell, Thomas J Ryan, Sidney C Smith. (1999) 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction. Journal of the American College of Cardiology 34:3, 890-911
    CrossRef

  366. 366

    Paul L. Ogburn, Richard D. Hurt, Ivana T. Croghan, Darrell R. Schroeder, Kirk D. Ramin, Kenneth P. Offord, Thomas P. Moyer. (1999) Nicotine patch use in pregnant smokers: Nicotine and cotinine levels and fetal effects. American Journal of Obstetrics and Gynecology 181:3, 736-743
    CrossRef

  367. 367

    Beth Nordstrom, Taru Kinnunen, Christopher Utman, Arthur Garvey. (1999) Long-term effects of nicotine gum on weight gain after smoking cessation. Nicotine & Tobacco Research 1:3, 259-268
    CrossRef

  368. 368

    Mike Franklin, Jingduan Chi, Cameron McGavin, Rena Hockney, Alison Reed, Gillian Campling, Richard W.R Whale, Phillip J Cowen. (1999) Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. Biological Psychiatry 46:4, 581-584
    CrossRef

  369. 369

    MICHAEL W. OWENS, BOAZ A. MARKEWITZ, D. KEITH PAYNE. (1999) Outpatient Management of Chronic Obstructive Pulmonary Disease. The American Journal of the Medical Sciences 318:2, 79
    CrossRef

  370. 370

    Ellen R. Gritz, Chris Schacherer, Laura Koehly, Ingrid R. Nielsen, Elliot Abemayor. (1999) Smoking withdrawal and relapse in head and neck cancer patients. Head & Neck 21:5, 420-427
    CrossRef

  371. 371

    H KRANZLER, H AMIN, V MODESTOLOWE, C ONCKEN. (1999) PHARMACOLOGIC TREATMENTS FOR DRUG AND ALCOHOL DEPENDENCE. Psychiatric Clinics of North America 22:2, 401-423
    CrossRef

  372. 372

    Jonathan Foulds. (1999) The relationship between tobacco use and mental disorders. Current Opinion in Psychiatry 12:3, 303-306
    CrossRef

  373. 373

    Lauri A. Laitinen, Kaj Koskela. (1999) Chronic bronchitis and chronic obstructive pulmonary disease: Finnish National Guidelines for Prevention and Treatment 1998–2007. Respiratory Medicine 93:5, 297-332
    CrossRef

  374. 374

    Paula D Riggs, Susan K Mikulich, Elizabeth A Whitmore, Thomas J Crowley. (1999) Relationship of ADHD, depression, and non-tobacco substance use disorders to nicotine dependence in substance-dependent delinquents1Portions of this paper were presented at the annual meeting of the College of Problems on Drug Dependence (Nashville, TN, 1997).1. Drug and Alcohol Dependence 54:3, 195-205
    CrossRef

  375. 375

    Anna M. Pou, Carl H. Snyderman. (1999) Strategies for curing tobacco addiction. Current Opinion in Otolaryngology & Head and Neck Surgery 7:2, 79
    CrossRef

  376. 376

    Lirio S. Covey, Alexander H. Glassman, Fay Stetner. (1999) Naltrexone Effects on Short-Term and Long-Term Smoking Cessation. Journal of Addictive Diseases 18:1, 31-40
    CrossRef

  377. 377

    Jorenby, Douglas E., Leischow, Scott J., Nides, Mitchell A., Rennard, Stephen I., Johnston, J. Andrew, Hughes, Arlene R., Smith, Stevens S., Muramoto, Myra L., Daughton, David M., Doan, Kimberli, Fiore, Michael C., Baker, Timothy B., . (1999) A Controlled Trial of Sustained-Release Bupropion, a Nicotine Patch, or Both for Smoking Cessation. New England Journal of Medicine 340:9, 685-691
    Full Text

  378. 378

    Meldon Kahan. (1999) TREATMENT. Evidence-based Cardiovascular Medicine 3:1, 15-16
    CrossRef

  379. 379

    Dorothy Hatsukami, Herbert Severson. (1999) Oral spit tobacco: addiction, prevention and treatment. Nicotine & Tobacco Research 1:1, 21-44
    CrossRef

  380. 380

    Thomas E. Kottke. (1999) Practical steps to smoking cessation. Evidence-based Cardiovascular Medicine 3:1, 4-5
    CrossRef

  381. 381

    Linda Sarna. (1999) Prevention: Tobacco control and cancer nursing. Cancer Nursing 22:1, 21-28
    CrossRef

  382. 382

    Stephen L. Dewey, Jonathan D. Brodie, Madina Gerasimov, Bryan Horan, Eliot L. Gardner, Charles R. Ashby. (1999) A pharmacologic strategy for the treatment of nicotine addiction. Synapse 31:1, 76-86
    CrossRef

  383. 383

    Anthony A. Floreani, Stephen I. Rennard. (1999) The role of cigarette smoke in the pathogenesis of asthma and as a trigger for acute symptoms. Current Opinion in Pulmonary Medicine 5:1, 38
    CrossRef

  384. 384

    THOMAS R. KOSTEN, ATHINA MARKOU, GEORGE F. KOOB. (1998) Depression and Stimulant Dependence. The Journal of Nervous & Mental Disease 186:12, 737-745
    CrossRef

  385. 385

    D. K. Taylor, K. R. Barber, B. A. McIntosh, M. Khan. (1998) The impact of post acute myocardial infarction (AMI) depression on patient compliance and risk factor modification. Psychology, Health & Medicine 3:4, 439-442
    CrossRef

  386. 386

    Maria L. Terry, Henry D. Berkowitz, Morris D. Kerstein, FACS. (1998) TOBACCO. Surgical Clinics of North America 78:3, 409-429
    CrossRef

  387. 387

    Jack E. Henningfield, Lakshmi Gopalan, Saul Shiffman. (1998) Tobacco dependence. Current Opinion in Psychiatry 11:3, 259-263
    CrossRef

  388. 388

    (1998) Sustained-Release Bupropion for Smoking Cessation. New England Journal of Medicine 338:9, 619-620
    Full Text

  389. 389

    (1998) The Evolving Pharmacotherapy of Smoking Cessation. Journal of General Internal Medicine 13:1, 55-57
    CrossRef

  390. 390

    Benowitz, Neal L., . (1997) Treating Tobacco Addiction — Nicotine or No Nicotine?. New England Journal of Medicine 337:17, 1230-1231
    Full Text

  391. 391

    John Britton, Alan Knox. (1997) No cures but some advances. The Lancet 350, SIII24
    CrossRef

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