Images in Clinical Medicine
Kim Eagle, M.D., Editor
Tamoxifen-Induced Endometrial Polyp
N Engl J Med 1996; 335:1650November 28, 1996
- Article
Figure 1 A 76-year-old woman with breast cancer who had been receiving adjuvant therapy with tamoxifen (20 mg per day) for 30 months presented with minimal vaginal bleeding. Color Doppler imaging revealed multiple arterial vessels with a very low resistance to flow (pulsatility index, 0.50; resistance index, 0.37) within the endometrium. The presence of a large endometrial polyp was demonstrated by the intrauterine instillation of sterile saline under ultrasonographic control (Panel A). Except for the large floating polyp (P), the endometrium (arrows) was thin and regular. M denotes the surrounding myometrium. The hysteroscopic view of the polyp, which measured 5.5 by 4.0 by 3.8 cm before its removal with a resectoscope, is shown in Panel B. Pathological examination disclosed a benign endometrial glandulocystic polyp without atypical cells. There were multiple small cysts lined with a single layer of epithelium. Tamoxifen was discontinued three weeks postoperatively. The patient stopped bleeding after the polyp was removed, and five months postoperatively, the endometrium had a normal appearance on ultrasonography.
Kim Eagle, M.D.
Dirk Timmerman, M.D.
Ignace Vergote, M.D., Ph.D.
University Hospitals Leuven, B-3000 Leuven, Belgium- Citing Articles (1)
Citing Articles
1
Patrick Neven, Ignace Vergote. (1998) Controversies regarding tamoxifen and uterine carcinoma. Current Opinion in Obstetrics and Gynaecology 10:1, 9-14
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