Images in Clinical Medicine

Kim Eagle, M.D., Editor

Toxic Epidermal Necrolysis

Ira A. Pion, M.D., and William Slue

N Engl J Med 1995; 333:1609December 14, 1995

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Article

Figure 1 A 40-year-old man was hospitalized after the development of toxic epidermal necrolysis on his chest (Panel A). The condition developed three weeks after the initiation of treatment with phenytoin and progressed caudally during a period of three days, involving 50 percent of the skin surfaces, as well as his fingernails (Panel B). The eruption stopped progressing within 48 hours after the phenytoin had been withdrawn. The erythema gradually abated, the erosions healed, and the patient was discharged two weeks later.

Kim Eagle, M.D.

Ira A. Pion, M.D.
William Slue
New York University Medical Center, New York, NY 10016