Images in Clinical Medicine
Kim Eagle, M.D., Editor
Castleman's Disease
N Engl J Med 1995; 333:776September 21, 1995
- Article
Figure 1 A 31-year-old woman who had had painless, right-sided cervical adenopathy for three months was given antibiotics, but the adenopathy persisted. She had no systemic symptoms and no other palpable lymph nodes, and the remainder of her physical examination was unremarkable. The results of all laboratory studies were normal. At surgery the node was 3 cm in diameter, tannish yellow, and rubbery. Histologic examination revealed numerous germinal centers pierced by capillaries emanating from a hypervascular pericortex and cuffed by small lymphocytes arranged in a concentric onionskin pattern (hematoxylin and eosin, ×925). These morphologic features are characteristic of Castleman's disease.
Because of the benign nature of the condition, the patient received no further therapy. Ten years after the node appeared, the patient is well and has had no recurrence of lymphadenopathy.
Kim Eagle, M.D.
Joshua Z. Sickel, M.D.
University of Rochester Medical Center, Rochester, NY 14642
