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Images in Clinical Medicine

Kim Eagle, M.D., Editor

Cytomegalovirus Retinitis in AIDS

Jan E.E. Keunen, M.D., Ph.D., and Aniki Rothova, M.D., Ph.D.

N Engl J Med 1995; 333:637September 7, 1995

Article

Figure 1 A 35-year-old man with the acquired immunodeficiency syndrome presented with floaters and blurred vision in both eyes. In the left eye (Panel A), the white wedge-shaped areas with accompanying hemorrhage along the inferior vascular arcade (arrows) represent necrosis of the retina. The arrowhead points to the optic disk. In the right eye (Panel B), the peripheral retina shows white sheathing along the blood vessels, so-called frosted-branch sheathing (arrows), a finding characteristic of vasculitis but not pathognomonic for cytomegalovirus retinitis.

The patient was treated with intravenous ganciclovir. The retinal lesions regressed, and vision improved. Six months later, the patient died of multiple opportunistic infections.

Kim Eagle, M.D.

Jan E.E. Keunen, M.D., Ph.D.
Aniki Rothova, M.D., Ph.D.
Academisch Ziekenhuis Utrecht, 3584 CX Utrecht, the Netherlands