Original Article
Increase in Circulating Products of Lipid Peroxidation (F2-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage
N Engl J Med 1995; 332:1198-1203May 4, 1995
- Abstract
Background
It has been hypothesized that the pathogenesis of diseases induced by cigarette smoking involves oxidative damage by free radicals. However, definitive evidence that smoking causes the oxidative modification of target molecules in vivo is lacking. We conducted a study to determine whether the production of F2-isoprostanes, which are novel products of lipid peroxidation, is enhanced in persons who smoke.
Methods
We measured the levels of free F2-isoprostanes in plasma, the levels of F2-isoprostanes esterified to plasma lipids, and the urinary excretion of metabolites of F2-isoprostanes in 10 smokers and 10 nonsmokers matched for age and sex. The short-term effects of smoking (three cigarettes smoked over 30 minutes) and the effects of two weeks of abstinence from smoking on levels of F2-isoprostanes in the circulation were also determined in the smokers.
Results
Plasma levels of free and esterified F2-isoprostanes were significantly higher in the smokers (mean ±SD, 242±147 and 574±217 pmol per liter, respectively) than in the nonsmokers (103±19 and 345±65 pmol per liter; P = 0.02 for free F2-isoprostanes and P = 0.03 for esterified F2-isoprostanes). Smoking had no short-term effects on the circulating levels of F2-isoprostanes. However, the levels of free and esterified F2-isoprostanes fell significantly after two weeks of abstinence from smoking (250±156 and 624±214 pmol per liter, respectively, before the cessation of smoking, as compared with 156±67 and 469±108 pmol per liter after two weeks' cessation; P = 0.03 for free F2-isoprostanes and P = 0.02 for esterified F2-isoprostanes).
Conclusions
The increased levels of F2-isoprostanes in the circulation of persons who smoke support the hypothesis that smoking can cause the oxidative modification of important biologic molecules in vivo.
Media in This Article
Figure 2
Levels of Free and Esterified F2-Isoprostanes in Plasma from Smokers and Nonsmokers.Figure 3
Levels of Free Circulating F2-Isoprostanes and the Urinary Excretion of an F2-Isoprostane Metabolite in Smokers (○) and Nonsmokers (●).Article Activity
- Article
Cigarette smoking is a serious health problem worldwide. Smoking has been strongly implicated as a risk factor for chronic obstructive pulmonary disease, cancer, and atherosclerosis.1-3 Because cigarette smoke is known to contain a large number of oxidants,4 it has been hypothesized that many of the adverse effects of smoking may result from oxidative damage to critical biologic substances. Such damage could result both from oxidants present in cigarette smoke and from the activation of phagocytic cells that generate reactive oxygen species.4,5
Oxidative inactivation of antiproteases may be involved in the development of chronic obstructive pulmonary disease, and oxidative modification of DNA can lead to the development of cancer.4,6,7 It has been shown that oxidatively modified low-density lipoprotein (LDL), but not native LDL, is recognized by scavenger receptors and taken up by macrophages, a process considered pivotal in the development of foam cells in atherosclerotic lesions.8 Thus, oxidation of LDL by cigarette smoke may contribute to the causative link between cigarette smoking and atherogenesis. Although previously there was controversy about whether direct exposure of LDL to cigarette smoke in vitro results in oxidative modification,9,10 we recently demonstrated the formation of lipid hydroperoxides after the exposure of plasma to the gas phase of cigarette smoke.11 Other evidence suggesting that smokers are subjected to oxidative stress includes the findings that they have lower levels of the antioxidant ascorbic acid (vitamin C) than nonsmokers and that smokers' risk of coronary artery disease correlates inversely with their intake of the antioxidants vitamin E and beta carotene.12-15
In spite of the circumstantial data from in vitro studies and measurements of antioxidant levels in smokers suggesting that cigarette smoke may cause oxidative injury, whether this process occurs in vivo has been controversial.10,16-18 The conflicting evidence can largely be attributed to the fact that most methods previously available to assess oxidative stress in humans have been inaccurate and unreliable.19
Recently, we discovered a series of bioactive prostaglandin F2–like compounds (termed F2-isoprostanes) that are produced independently of the cyclooxygenase enzyme in humans by the peroxidation of arachidonic acid, catalyzed by free radicals (Figure 1Figure 1
Mechanism of Formation and Structures of the F2-Isoprostanes.).20 F2-isoprostanes are initially formed in situ on phospholipids and are subsequently released preformed.21 Levels of F2-isoprostanes in normal human biologic fluids exceed those of cyclooxygenase-derived prostanoids by approximately one to two orders of magnitude. In addition, levels of F2-isoprostanes — both free in the circulation and esterified to tissue phospholipids — increase dramatically in animal models of oxidant injury.21,22 The most widely used test of lipid peroxidation is the measurement of malondialdehyde with the thiobarbituric acid–reacting substances assay.19 We recently demonstrated that the F2-isoprostane level is far superior to measurements of thiobarbituric acid–reacting substances as an index of lipid peroxidation in vivo.23 Thus, the discovery of F2-isoprostanes is considered an important advance in our ability to detect oxidant injury.We undertook this study to assess the hypothesis that cigarette smoking can cause oxidative modification of important biologic molecules in humans by determining whether the production of F2-isoprostanes is increased in persons who smoke.
Methods
Measurements of F2-Isoprostanes
Blood was drawn into Vacutainer tubes containing EDTA and immediately centrifuged to separate the plasma. An aliquot of plasma was then removed and stored at -70°C for measurement of lipid-soluble antioxidants. For ascorbic acid and uric acid measurements, the plasma was extracted with metaphosphoric acid before storage at -70°C. The remainder of the plasma was immediately processed for the measurement of F2-isoprostanes. Levels of free F2-isoprostanes in plasma and of F2-isoprostanes esterified to plasma lipids were measured by stable-isotope-dilution mass-spectrometric assay.24 The precision of the assay for free F2-isoprostanes is ±6 percent, and the accuracy is 96 percent. The precision of the assay for esterified F2-isoprostanes in plasma is ±8 percent. Data are expressed in picomoles per liter. We recently identified tetranor dicarboxylic acid urinary metabolites of F2-isoprostanes that contain one keto group and one double bond with a molecular weight of 328.25 These metabolites were measured by a mass-spectrometric method, previously described,25 that has a precision of ±12 percent. Data are expressed in picomoles per millimole of creatinine.
Measurements of Antioxidants in Plasma
Plasma concentrations of ascorbic acid (vitamin C), uric acid, alpha- and gamma-tocopherol (vitamin E), alpha and beta carotene, cryptoxanthin, lycopene, lutein and zeaxanthin, and retinol were measured by high-performance liquid chromatography.26,27 Data are expressed in micromoles per liter for water-soluble antioxidants and retinol and in micromoles per millimole of total lipids (the sum of cholesterol and triglycerides) for lipid-soluble compounds.
Measurements of Urinary Nicotine and Cotinine
Concentrations of nicotine and its metabolite, cotinine, in urine were quantified by high-performance liquid chromatography; the results are expressed in micromoles per liter.28
Clinical Protocols
Two separate clinical studies were performed. Both were approved by the human studies committees of the medical centers involved, and informed consent was obtained from all subjects. Initially, we carried out a pilot study in which we recruited 24 subjects (16 who smoked one to two packs of cigarettes per day and 8 nonsmokers). Twelve of the subjects were apparently healthy; six of the smokers had angiographically or clinically documented coronary artery disease; and six subjects (two nonsmokers and four smokers) had hypertension. Patients with these conditions were receiving medical therapy. No subjects took vitamin supplements. Blood was collected on a single occasion after an overnight fast for measurement of F2-isoprostanes.
After the completion of the pilot study, we carried out a second, more detailed, validation study for which we recruited 10 smokers (who smoked more than 1.5 packs of cigarettes per day) and 10 nonsmokers matched with the smokers for age and sex. The nonsmokers were not exposed to passive smoke at work or at home. Five men and five women made up each of the study groups. All the subjects included in the study had a normal physical examination, electrocardiogram, and blood-chemistry tests (complete blood count and the 18 tests of the Sequential Multiple Analyzer 18 system) and had no apparent underlying disease. None were taking medications or vitamin supplements.
The study protocol was as follows. On day 1, the smokers were studied at 8 a.m. and were not allowed to smoke or eat before the first blood sample was obtained. After blood was obtained for measurements of F2-isoprostanes and circulating antioxidants, the subjects smoked three cigarettes during a 30-minute period, after which blood was again obtained for analysis of F2-isoprostanes. The same procedure was repeated on day 3 of the study. The average of the two measurements of F2-isoprostanes in blood obtained on days 1 and 3 is reported here. The median variance in the levels of F2-isoprostanes measured on separate days did not exceed 12 percent. A 24-hour urine specimen was collected on day 1 for measurement of F2-isoprostane metabolites; urine was also collected on day 1 for measurement of nicotine and cotinine. For nonsmokers, blood was obtained for measurement of F2-isoprostanes on days 1 and 3 of the study and for measurement of antioxidants on day 1. Urine was collected on day 1 for measurement of F2-isoprostane metabolites.
The subjects who smoked were then instructed to cease smoking for a period of two weeks. No nicotine-replacement therapy (such as nicotine patches) was used. Two of the 10 smokers were unable to quit smoking. After the cessation of smoking, blood was again obtained on two separate days for the measurement of F2-isoprostanes. Urine samples were collected at the end of the two-week period of abstinence from smoking for measurement of nicotine and cotinine to monitor compliance.
Statistical Analysis
In the pilot study, data were analyzed with the Wilcoxon rank-sum test. In the second study, smokers and nonsmokers were matched in terms of age and sex. Data were therefore analyzed using the Wilcoxon signed-rank test. Tests of the Spearman (nonparametric) correlation were used to assess the association of F2-isoprostane levels with other measurements. All data are expressed as means ±SD. Differences were considered statistically significant if the P value was 0.05 or lower.
Results
Pilot Study
Initially, we compared levels of F2-isoprostanes in 16 smokers and 8 age-matched nonsmokers. All but one of the subjects were male. The smokers ranged in age from 43 to 72 years (mean, 55.2±8.3). The nonsmokers ranged in age from 47 to 71 years (mean, 54.4±8.7). The smokers smoked an average of 1.4±0.5 packs of cigarettes per day (28±10 cigarettes). The cumulative total of cigarettes smoked ranged from 20 to 100 pack-years. As shown in Table 1Table 1
Clinical and Laboratory Data on Subjects in the Pilot Study., levels of free F2-isoprostanes in the circulation and F2-isoprostanes esterified to plasma lipids were significantly higher in the smokers than in the nonsmokers (P = 0.02 and P = 0.05, respectively).Validation Study
The finding that levels of F2-isoprostanes in the circulation were significantly higher among the smokers in the pilot study provided the impetus to conduct a more extensive, well-controlled study, not only to confirm the results of the pilot study but also to determine the short-term effects of smoking and the effects of abstinence from smoking on the production of F2-isoprostanes. Unlike the pilot study, the validation study enrolled only young persons who had no apparent underlying disease and were taking no medications. In addition, equal numbers of male and female subjects were studied. The smokers in this study all smoked more than 1.5 packs of cigarettes per day (mean, 1.85±0.25 packs per day [37±5 cigarettes]). The smokers had from 4 to 50 pack-years of smoking (mean, 22±11). A variety of brands of cigarettes were used, but the mean tar content was 10.8±3.4 mg per cigarette and the mean nicotine content was 0.8±0.2 mg per cigarette. Additional characteristics of the subjects are summarized in Table 2Table 2
Clinical and Laboratory Data on Subjects in the Validation Study..Measurements of F2-Isoprostanes
The levels of free F2-isoprostanes in plasma from smokers (242±147 pmol per liter) were significantly higher than those measured in age- and sex-matched nonsmokers (103±19 pmol per liter, P = 0.02) (Figure 2Figure 2
Levels of Free and Esterified F2-Isoprostanes in Plasma from Smokers and Nonsmokers.). The levels of F2-isoprostanes esterified to lipids in plasma from smokers (574±217 pmol per liter) were also significantly higher than those measured in nonsmokers (345±65 pmol per liter, P = 0.03) (Figure 2). No association was found between levels of F2-isoprostanes in smokers and sex, age, weight, height, serum cholesterol or triglyceride levels, history of smoking in pack-years, number of cigarettes smoked per day, or the tar and nicotine content of the cigarettes smoked.Measurement of the urinary excretion of prostanoid metabolites has proved to be an extremely reliable method of assessing the endogenous production of prostanoids.29 Therefore, we sought further confirmation of the overproduction of F2-isoprostanes in smokers by quantifying the urinary excretion of F2-isoprostane metabolites.25 The urinary excretion of the metabolites in smokers (870±509 pmol per millimole of creatinine) was significantly higher than that in nonsmokers (415±155 pmol per millimole of creatinine, P = 0.05). In addition, we found a significant correlation (r = 0.97, P<0.001) between the urinary excretion of F2-isoprostane metabolites and circulating concentrations of free F2-isoprostanes in smokers and nonsmokers (Figure 3Figure 3
Levels of Free Circulating F2-Isoprostanes and the Urinary Excretion of an F2-Isoprostane Metabolite in Smokers (○) and Nonsmokers (●).).We next determined the short-term effect of smoking on circulating levels of F2-isoprostanes in the 10 smokers. We found no significant differences in the levels measured in blood obtained in the morning before smoking and the levels measured immediately after the subjects smoked three cigarettes during a 30-minute period. The mean plasma level of free F2-isoprostanes was 242±147 pmol per liter before smoking and 237±117 pmol per liter after smoking (P = 0.43). The mean level of F2-isoprostanes esterified to plasma lipids was 574±217 pmol per liter before smoking and 624±214 pmol per liter after smoking (P = 0.20).
Effect of Abstinence from Smoking on F2-Isoprostane Levels
Eight of the 10 smokers who entered this study were able to stop smoking for two weeks. Levels of both free and esterified F2-isoprostanes in the plasma of these eight subjects after two weeks of abstinence from smoking were significantly lower than the levels measured during smoking (Figure 4Figure 4
Percent Change in the Levels of Free and Esterified F2-isoprostanes in Plasma from Smokers after Two Weeks of Abstinence from Smoking.). The mean free F2-isoprostane level during smoking was 250±156 pmol per liter; after two weeks of abstinence it had fallen to 156±67 pmol per liter (P = 0.03). The mean level of F2-isoprostanes esterified to plasma lipids during smoking was 624±214 pmol per liter, and after two weeks of abstinence it had fallen to 469±108 pmol per liter (P = 0.02). Cessation of smoking was confirmed by the finding that levels of urinary nicotine and cotinine measured during the smoking period (1.17±0.87 μmol per liter and 1.05±0.65 μmol per liter, respectively) fell to undetectable levels (<0.03 μmol per liter for each compound) in each subject after two weeks of abstinence from smoking.Levels of Circulating Antioxidants
Plasma levels of uric acid, alpha-tocopherol, gamma-tocopherol, alpha carotene, beta carotene, lycopene, lutein and zeaxanthin, cryptoxanthin, total carotenoids, and retinol did not differ significantly between smokers and nonsmokers in the validation study (P>0.05). In accordance with the results of previous studies,12-14 plasma ascorbate levels were significantly lower in the smokers (25.8±18.4 μmol per liter) than in the nonsmokers (54.3±19.1 μmol per liter, P = 0.002); in this study we did not control for vitamin C intake.
Discussion
Our finding that the production of F2-isoprostanes is higher in smokers than in nonsmokers provides compelling evidence that smoking causes oxidative modification of biologic components in humans. This conclusion is greatly strengthened by the finding that levels of F2-isoprostanes in the smokers fell significantly after two weeks of abstinence from smoking. These results provide a basis for hypotheses that link oxidative damage of critical target biomolecules to the pathogenesis of diseases caused by smoking.
The results of previous studies of smoking and oxidative injury in humans have been conflicting and difficult to interpret. The most widely used test for oxidative stress is the measurement of malondialdehyde, a product of lipid peroxidation, by the thiobarbituric acid–reacting substances assay.19 Harats and colleagues found no significant differences between smokers and nonsmokers in the levels of thiobarbituric acid–reacting substances in freshly prepared plasma or LDL.10 However, other groups have reported that the levels of thiobarbituric acid–reacting substances are significantly higher in plasma from smokers than in plasma from nonsmokers.16,30 The reason for these discrepancies may be that the measurement of thiobarbituric acid–reacting substances is not an accurate indicator of lipid peroxidation in biologic samples.19 Another method of assessing lipid peroxidation in vivo is the measurement of exhaled alkanes, such as ethane and pentane; pentane exhalation has been reported to be higher in smokers.31 However, the accuracy of exhaled pentane as a marker of endogenous lipid peroxidation has been questioned.32
On the other hand, we have shown previously that circulating levels of F2-isoprostanes appear to provide an accurate measure of lipid peroxidation in vivo.20,22,23 In the current study, we found higher levels of both free F2-isoprostanes in the circulation and F2-isoprostanes esterified to plasma lipids in smokers than in nonsmokers. The finding that levels of esterified F2-isoprostanes were higher in smokers extends our previous findings from in vitro studies that F2-isoprostanes are formed in plasma and LDL exposed to oxidative stress.33 As previously discussed, oxidative modification of LDL is thought to be a key process in the development of atherosclerosis. Thus, the finding that plasma lipids from smokers have been modified by oxidation may provide a mechanistic link between cigarette smoking and atherogenesis. However, we did not show in this study that LDL itself was oxidatively modified. Although the vast majority of circulating lipids are associated with lipoproteins,34 further studies will be required to determine to what extent LDL and other lipoproteins are oxidatively modified by cigarette smoking.
Interestingly, only slightly increased levels of F2-isoprostanes, or none, were found in some of the smokers studied. This finding is of interest in view of the fact that some people appear more resistant than others to the toxic effects of smoking. The reason for this apparent heterogeneity in susceptibility to the oxidative effects of smoking is unclear. However, the ability to identify smokers who have only slightly increased levels of F2-isoprostanes and those with more marked overproduction of F2-isoprostanes may make it possible to explore the reasons for these differences. We did not find any relation between F2-isoprostane production and age, sex, number of pack-years of smoking, or number of cigarettes smoked per day. It is possible that differences in antioxidant defense capacity affect susceptibility to the oxidant effects of cigarette smoke. In this regard, we did find, as have others, that smokers had substantially lower plasma concentrations of ascorbate than nonsmokers. Because we did not control for vitamin C intake, however, it remains to be determined whether this relation reflects increased utilization of ascorbate by smokers or decreased intake.
Supported by grants (GM-42056, GM-15431, HL-49954, ES-00267, and RR-00095) from the National Institutes of Health. Dr. Morrow is a Howard Hughes Medical Institute Physician Research Fellow and the recipient of a Research Foundation Award from the International Life Sciences Institute. Dr. Frei is the recipient of a Future Leader Award from the International Life Sciences Institute–Nutrition Foundation.
We are indebted to William Zackert, Aiping Wu, Gary Cunningham, Elizabeth Shipp, Gwenn Sobo, Vincent Daniel, Timi Mannion, and Jim Anderson for expert technical assistance; to Kathy Cunningham for assistance in the preparation of the manuscript; and to Dr. Robert Parker for advice on the statistical analysis of data.
Source Information
From the Departments of Medicine and Pharmacology (J.D.M., A.W.L., J.A.O., L.J.R.) and the Division of Biostatistics, Department of Preventive Medicine (Y.S.), Vanderbilt University, Nashville; the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (B.F., S.M.L.); the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (J.M.G.); and the Section of Cardiology, Brockton–West Roxbury Veterans Affairs Medical Center and Harvard Medical School, Boston (W.E.S.).
Address reprint requests to Dr. Morrow at the Departments of Pharmacology and Medicine, 506 MRB, Vanderbilt University, Nashville, TN 37232-6602.
- References
References
1
Doll R ,Peto R . Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health 1978;32:303-313
CrossRef | Web of Science | Medline2
Hoidal JR ,Niewoehner DE . Pathogenesis of emphysema. Chest 1983;83:679-685
CrossRef | Web of Science | Medline3
Kannel WB . Update on the role of cigarette smoking in coronary artery disease. Am Heart J 1981;101:319-328
CrossRef | Web of Science | Medline4
Church DF ,Pryor WA . Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985;64:111-126
CrossRef | Web of Science | Medline5
Lehr HA ,Kress E ,Menger MD , et al. Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: inhibition by CuZn-SOD. Free Radic Biol Med 1993;14:573-581
CrossRef | Web of Science | Medline6
Cantin A ,Crystal RG . Oxidants, antioxidants and the pathogenesis of emphysema. Eur J Respir Dis 1985;139:Suppl:7-177
O'Brien PJ . Radical formation during the peroxidase catalyzed metabolism of carcinogens and xenobiotics: the reactivity of these radicals with GSH, DNA, and unsaturated lipid. Free Radic Biol Med 1988;4:169-183
CrossRef | Web of Science | Medline8
Steinberg D ,Parthasarathy S ,Carew TE ,Khoo JC ,Witztum JL . Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-924
Full Text | Web of Science | Medline9
Yokode M ,Kita T ,Arai H ,Kawai C ,Narumiya S ,Fujiwara M . Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract. Proc Natl Acad Sci U S A 1988;85:2344-2348
CrossRef | Web of Science | Medline10
Harats D ,Ben-Naim M ,Dabach Y ,Hollander G ,Stein O ,Stein Y . Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages. Atherosclerosis 1989;79:245-252
CrossRef | Web of Science | Medline11
Frei B ,Forte TM ,Ames BN ,Cross CE . Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma: protective effects of ascorbic acid. Biochem J 1991;277:133-138
Web of Science | Medline12
Pelletier O . Vitamin C status of cigarette smokers and nonsmokers. Am J Clin Nutr 1970;23:520-524
Web of Science | Medline13
Chow CK ,Thacker RR ,Changchit C , et al. Lower levels of vitamin C and carotenes in plasma of cigarette smokers. J Am Coll Nutr 1986;5:305-312
Web of Science | Medline14
Schectman G ,Byrd JC ,Gruchow HW . The influence of smoking on vitamin C status in adults. Am J Public Health 1989;79:158-162
CrossRef | Web of Science | Medline15
Rimm EB ,Stampfer MJ ,Ascherio A ,Giovannucci E ,Colditz GA ,Willett WC . Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-1456
Full Text | Web of Science | Medline16
Kalra J ,Chaudhary AK ,Prasad K . Increased production of oxygen free radicals in cigarette smokers. Int J Exp Pathol 1991;72:1-7
Web of Science | Medline17
Duthie GG ,Arthur JR ,James WPT . Effects of smoking and vitamin E on blood antioxidant status. Am J Clin Nutr 1991;53:Suppl:1061S-1063S
Web of Science | Medline18
Chow CK . Cigarette smoking and oxidative damage in the lung. Ann N Y Acad Sci 1993;686:289-298
CrossRef | Web of Science | Medline19
Gutteridge JMC ,Halliwell B . The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 1990;15:129-135
CrossRef | Web of Science | Medline20
Morrow JD ,Hill KE ,Burk RF ,Nammour TM ,Badr KF ,Roberts LJ . A series of prostaglandin F2-like compounds are produced in vivo in humans by a noncyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A 1990;87:9383-9387
CrossRef | Web of Science | Medline21
Morrow JD ,Awad JA ,Boss HJ ,Blair IA ,Roberts LJ . Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci U S A 1992;89:10721-10725
CrossRef | Web of Science | Medline22
Morrow JD ,Awad JA ,Kato T , et al. Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity: an animal model of lipid peroxidation. J Clin Invest 1992;90:2502-2507
CrossRef | Web of Science | Medline23
Longmire AW ,Swift LL ,Roberts LJ II ,Awad JA ,Burk RF ,Morrow JD . Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol 1994;47:1173-1177
CrossRef | Web of Science | Medline24
Morrow JD ,Roberts LJ II . Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism. Methods Enzymol 1994;233:163-174
CrossRef | Web of Science | Medline25
Awad JA ,Morrow JD ,Takahashi K ,Roberts LJ . Identification of noncyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma. J Biol Chem 1993;268:4161-4169
Web of Science | Medline26
Frei B ,England L ,Ames BN . Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 1989;86:6377-6381
CrossRef | Web of Science | Medline27
Hess D ,Keller HE ,Oberlin B ,Bonfanti R ,Schuep W . Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase. Int J Vitam Nutr Res 1991;61:232-238
Web of Science | Medline28
Kyerematen GA ,Damiano MD ,Dvorchik BH ,Vesell ES . Smoking-induced changes in nicotine disposition: application of a new HPLC assay for nicotine and its metabolites. Clin Pharmacol Ther 1982;32:769-780
CrossRef | Web of Science | Medline29
Roberts LJ. Comparative metabolism and fate of the eicosanoids. In: Willis AL, ed. CRC handbook of eicosanoids: prostaglandins and related lipids. Vol. 1. Part A. Boca Raton, Fla.: CRC Press, 1987:233-44.
30
Bridges AB ,Scott NA ,Parry GJ ,Belch JJF . Age, sex, cigarette smoking and indices of free radical activity in healthy humans. Eur J Med 1993;2:205-208
Medline31
Mohler ER ,Fineberg NS ,Hathaway DR . Breath pentane, a byproduct of lipid peroxidation, is elevated and antioxidant vitamins decreased in smokers. Circulation 1992;86:Suppl I:I-86532
Cailleux A ,Allain P . Is pentane a normal constituent of human breath? Free Radic Res 1993;18:323-327
CrossRef | Web of Science33
Lynch SM ,Morrow JD ,Roberts LJ ,Frei B . Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Invest 1994;93:998-1004
CrossRef | Web of Science | Medline34
Schonfeld G. Disorders of lipoprotein transport. In: DeGroot LJ, ed. Endocrinology. 2nd ed. Vol. 3. Philadelphia: W.B. Saunders, 1989:2424-53.
- Citing Articles (404)
Citing Articles
1
Agnieszka Szlagatys-Sidorkiewicz, Maciej Zagierski, Grażyna Łuczak, Katarzyna Macur, Tomasz Bączek, Barbara Kamińska. (2012) Maternal Smoking Does Not Influence Vitamin A and E Concentrations in Mature Breastmilk. Breastfeeding Medicine120207064218001
CrossRef2
A. Z. Pollack, E. F. Schisterman, L. R. Goldman, S. L. Mumford, N. J. Perkins, M. S. Bloom, C. B. Rudra, R. W. Browne, J. Wactawski-Wende. (2012) Relation of Blood Cadmium, Lead, and Mercury Levels to Biomarkers of Lipid Peroxidation in Premenopausal Women. American Journal of Epidemiology
CrossRef3
Ramin Miri, Hamideh Saadati, Pegah Ardi, Omidreza Firuzi. (2011) Alterations in oxidative stress biomarkers associated with mild hyperlipidemia and smoking. Food and Chemical Toxicology
CrossRef4
S. Taito, K. Sekikawa, S. Domen, K. Konishi, T. Kimura, M. Takahashi, T. Inamizu, H. Hamada. (2011) Pulmonary Oxidative Stress Is Induced by Maximal Exercise in Young Cigarette Smokers. Nicotine & Tobacco Research
CrossRef5
Judith A. Voynow, Apparao Kummarapurugu. (2011) Isoprostanes and asthma. Biochimica et Biophysica Acta (BBA) - General Subjects 1810:11, 1091-1095
CrossRef6
Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, Marina Zaromitidou, Aleksis Verveniotis, Aris Plastiras, Stamatios Kioufis, Konstantinos Maniatis, Antigoni Miliou, Zoi Siasou, Christodoulos Stefanadis, Athanasios G. Papavassiliou. (2011) Effects of omega-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: A cross over study. International Journal of Cardiology
CrossRef7
Michael A. Rosenbaum, Keiko Miyazaki, Linda M. Graham. (2011) Hypercholesterolemia and oxidative stress inhibit endothelial cell healing after arterial injury. Journal of Vascular Surgery
CrossRef8
Ginger L. Milne, Huiyong Yin, Klarissa D. Hardy, Sean S. Davies, L. Jackson Roberts. (2011) Isoprostane Generation and Function. Chemical Reviews 111:10, 5973-5996
CrossRef9
Milam A. Brantley, Melissa P. Osborn, Barton J. Sanders, Kasra A. Rezaei, Pengcheng Lu, Chun LI, Ginger L. Milne, Jiyang Cai, Paul Sternberg. (2011) Plasma Biomarkers of Oxidative Stress and Genetic Variants in Age-Related Macular Degeneration. American Journal of Ophthalmology
CrossRef10
Sibel Doruk, Huseyin Ozyurt, Handan Inonu, Unal Erkorkmaz, Oguzhan Saylan, Zehra Seyfikli. (2011) Oxidative status in the lungs associated with tobacco smoke exposure. Clinical Chemistry and Laboratory Medicine---
CrossRef11
Michael Goodman, Roberd M. Bostick, Omer Kucuk, Dean P. Jones. (2011) Clinical trials of antioxidants as cancer prevention agents: Past, present, and future. Free Radical Biology and Medicine 51:5, 1068-1084
CrossRef12
James E. Klaunig, Zemin Wang, Xinzhu Pu, Shaoyu Zhou. (2011) Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicology and Applied Pharmacology 254:2, 86-99
CrossRef13
Tsogzolmaa Dorjgochoo, Yu-Tang Gao, Wong-Ho Chow, Xiao-ou Shu, Gong Yang, Quiyin Cai, Nathaniel Rothman, Hui Cai, Honglan Li, Xinqing Deng, Martha J. Shrubsole, Harvey Murff, Ginger Milne, Wei Zheng, Qi Dai. (2011) Obesity, Age, and Oxidative Stress in Middle-Aged and Older Women. Antioxidants & Redox Signaling 14:12, 2453-2460
CrossRef14
Kasper Broedbaek, Rasmus Ribel-Madsen, Trine Henriksen, Allan Weimann, Morten Petersen, Jon T. Andersen, Shoaib Afzal, Brian Hjelvang, L. Jackson Roberts, Allan Vaag, Pernille Poulsen, Henrik E. Poulsen. (2011) Genetic and environmental influences on oxidative damage assessed in elderly Danish twins. Free Radical Biology and Medicine 50:11, 1488-1491
CrossRef15
Virginia A. Pujol Lereis, Sebastian Ameriso, Guillermo P. Povedano, Sebastián F. Ameriso. (2011) Ischemic Stroke in Patients Receiving Aspirin. Journal of Stroke and Cerebrovascular Diseases
CrossRef16
Raymond C.S. Seet, Chung-Yung J. Lee, Wai Mun Loke, Shan Hong Huang, Huiwen Huang, Woan Foon Looi, Eng Soh Chew, Amy M.L. Quek, Erle C.H. Lim, Barry Halliwell. (2011) Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress?. Free Radical Biology and Medicine 50:12, 1787-1793
CrossRef17
Frederic T. Billings, Stephen K. Ball, L. Jackson Roberts, Mias Pretorius. (2011) Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Free Radical Biology and Medicine 50:11, 1480-1487
CrossRef18
S. S. Barbieri, E. Zacchi, P. Amadio, S. Gianellini, L. Mussoni, B. B. Weksler, E. Tremoli. (2011) Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction. Cardiovascular Research 90:3, 475-483
CrossRef19
Sang Don Lee, Gawon Ju, Ji-Ae Choi, Jeong-Whun Kim, In-Young Yoon. (2011) The association of oxidative stress with central obesity in obstructive sleep apnea. Sleep and Breathing
CrossRef20
Arun K. Tewari, Alexandra Popova-Butler, Mohamed A. El-Mahdy, Jay L. Zweier. (2011) Identification of differentially expressed proteins in blood plasma of control and cigarette smoke-exposed mice by 2-D DIGE/MS. PROTEOMICS 11:10, 2051-2062
CrossRef21
Katie Grimshaw, Julie Sahler, Sherry L. Spinelli, Richard P. Phipps, Neil Blumberg. (2011) New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells. Transfusion 51:4, 874-880
CrossRef22
Maarten G. J. Snoeijs, Annemarie van Bijnen, Els Swennen, Guido R. M. M. Haenen, L. Jackson Roberts, Maarten H. L. Christiaans, Arnoud G. Peppelenbosch, Wim A. Buurman, L. W. Ernest van Heurn. (2011) Tubular Epithelial Injury and Inflammation After Ischemia and Reperfusion in Human Kidney Transplantation. Annals of Surgery 253:3, 598-604
CrossRef23
Sean S. Davies, L. Jackson Roberts. (2011) F2-isoprostanes as an indicator and risk factor for coronary heart disease. Free Radical Biology and Medicine 50:5, 559-566
CrossRef24
Tae-Gyu Nam. (2011) Lipid Peroxidation and Its Toxicological Implications. Toxicological Research 27:1, 1-6
CrossRef25
Mohammad Ramezani, Fatemeh Nazemian, Jamal Shamsara, Reza Koohrokhi, Amir Hooshang Mohammadpour. (2011) Effect of Omega-3 Fatty Acids on Plasma Level of 8-Isoprostane in Kidney Transplant Patients. Journal of Renal Nutrition 21:2, 196-199
CrossRef26
Carlos Campos, Rodrigo Guzmán, Encarnación López-Fernández, Ángela Casado. (2011) Urinary biomarkers of oxidative/nitrosative stress in healthy smokers. Inhalation Toxicology 23:3, 148-156
CrossRef27
Ayhan A. Zia, Babatunde O. Komolafe, Marriyam Moten, Robert A. Ahokas, Jesse E. McGee, E. William Rosenberg, Syamal K. Bhattacharya, Karl T. Weber. (2011) Supplemental Vitamin D and Calcium in the Management of African Americans With Heart Failure Having Hypovitaminosis D. The American Journal of the Medical Sciences 341:2, 113-118
CrossRef28
Paolo Usai, Ivan Ibba, Mariantonia Lai, Maria Francesca Boi, Maria Flavia Savarese, Rosario Cuomo, Giuseppe D’Alia, Sergio Gemini, Giacomo Diaz, Paolo Contu. (2011) Cigarette smoking and appendectomy: Effect on clinical course of diverticulosis. Digestive and Liver Disease 43:2, 98-101
CrossRef29
Harold C Box, Richard J O'Connor, Helen B Patrzyc, Herbert Iijima, Jean B Dawidzik, Harold G Freund, Edwin E Budzinski, K Michael Cummings, Martin C Mahoney. (2011) Reduction in oxidatively generated DNA damage following smoking cessation. Tobacco Induced Diseases 9:1, 5
CrossRef30
David Katoshevski, Michal Ruzal-Mendelevich, Itamar Hite, Eran Sher. (2011) Environmental and Health Risk Associated with Air pollution Emitted by Public Transportation, and a New Methodology for Reducing the Risk. Procedia - Social and Behavioral Sciences 20, 687-692
CrossRef31
Michalis G. Nikolaidis, Antonios Kyparos, Ioannis S. Vrabas. (2011) F2-isoprostane formation, measurement and interpretation: The role of exercise. Progress in Lipid Research 50:1, 89-103
CrossRef32
Kyong Park, Eric Rimm, David Siscovick, Donna Spiegelman, J. Steven Morris, Dariush Mozaffarian. (2011) Demographic and lifestyle factors and selenium levels in men and women in the U.S.. Nutrition Research and Practice 5:4, 357
CrossRef33
Ingrid Avalos, C. Michael Stein. 2011. Atherosclerosis and Tissue Injury in Systemic Lupus Erythematosus. , 513-522.
CrossRef34
Mohammad Nasir Uddin, Enoch E. Agunanne, Darijana Horvat, Jules B. Puschett. (2010) Resibufogenin Administration Prevents Oxidative Stress in a Rat Model of Human Preeclampsia. Hypertension in Pregnancy1-9
CrossRef35
M. Charakida, S. Masi, T. F. Luscher, J. J. P. Kastelein, J. E. Deanfield. (2010) Assessment of atherosclerosis: the role of flow-mediated dilatation. European Heart Journal 31:23, 2854-2861
CrossRef36
E. SCHWEDHELM, A. BIEREND, R. MAAS, R. TRINKS, G. D. KOM, D. TSIKAS, R. H. BÖGER. (2010) Redox-generated isoprostanes are associated with residual platelet activity in aspirin-treated patients with stable coronary heart disease. Journal of Thrombosis and Haemostasis 8:12, 2662-2670
CrossRef37
Rani Sauriasari, Noriko Sakano, Da-Hong Wang, Jiro Takaki, Kei Takemoto, BingLing Wang, Hitoshi Sugiyama, Yoshie Sato, Tomoko Takigawa, Noriko Takahashi, Sakiko Kanbara, Yoshiaki Hitomi, Hiroyuki Nakamura, Keiki Ogino. (2010) C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population. Hypertension Research 33:11, 1129-1136
CrossRef38
Samar Basu. (2010) Bioactive eicosanoids: Role of prostaglandin F2α and F2-isoprostanes in inflammation and oxidative stress related pathology. Molecules and Cells 30:5, 383-391
CrossRef39
Fangwen Rao, Kuixing Zhang, Srikrishna Khandrika, Manjula Mahata, Maple M. Fung, Michael G. Ziegler, Brinda K. Rana, Daniel T. O'Connor. (2010) Isoprostane, an “Intermediate Phenotype” for Oxidative Stress. Journal of the American College of Cardiology 56:16, 1338-1350
CrossRef40
Young Hee Rho, Cecilia P. Chung, Annette Oeser, Joseph F. Solus, Tebeb Gebretsadik, Ayumi Shintani, Paolo Raggi, Ginger L. Milne, C. Michael Stein. (2010) Interaction between oxidative stress and high-density lipoprotein cholesterol is associated with severity of coronary artery calcification in rheumatoid arthritis. Arthritis Care & Research 62:10, 1473-1480
CrossRef41
Joshua D. Brooks, Brian E. Cox, Klarissa D. Hardy, Stephanie C. Sanchez, Sonia Tourino, Tyler H. Koestner, Jocelyn R. Hyman-Howard, Ginger L. Milne. 2010. The Isoprostanes: Accurate Markers and Potent Mediators of Oxidant Injury in Vivo. , 65-84.
CrossRef42
M. S. Hershfield, L. J. Roberts, N. J. Ganson, S. J. Kelly, I. Santisteban, E. Scarlett, D. Jaggers, J. S. Sundy. (2010) Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. Proceedings of the National Academy of Sciences 107:32, 14351-14356
CrossRef43
Barry Halliwell, Chung Yung J. Lee. (2010) Using Isoprostanes as Biomarkers of Oxidative Stress: Some Rarely Considered Issues. Antioxidants & Redox Signaling 13:2, 145-156
CrossRef44
A. M. El-Tawil. (2010) Smoking and inflammatory bowel diseases: what in smoking alters the course?. International Journal of Colorectal Disease 25:6, 671-680
CrossRef45
H. D. Hosgood, C. S. Liu, N. Rothman, S. J. Weinstein, M. R. Bonner, M. Shen, U. Lim, J. Virtamo, W. l. Cheng, D. Albanes, Q. Lan. (2010) Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis 31:5, 847-849
CrossRef46
J. Ju, S. C. Picinich, Z. Yang, Y. Zhao, N. Suh, A. N. Kong, C. S. Yang. (2010) Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis 31:4, 533-542
CrossRef47
Samar Basu. (2010) Fatty acid oxidation and isoprostanes: Oxidative strain and oxidative stress. Prostaglandins, Leukotrienes and Essential Fatty Acids 82:4-6, 219-225
CrossRef48
Baher Fahmy, Liren Ding, Dahui You, Slawo Lomnicki, Barry Dellinger, Stephania A. Cormier. (2010) In vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles. Environmental Toxicology and Pharmacology 29:2, 173-182
CrossRef49
Pei-Ling Yen, Bing-Huei Chen, Feili Lo Yang, Yi-Fa Lu. (2010) Effects of deep-frying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats. Nutrition 26:3, 331-336
CrossRef50
A. I. Papaioannou, A. Koutsokera, K. Tanou, T. S. Kiropoulos, I. Tsilioni, S. Oikonomidi, K. Liadaki, S. Pournaras, K. I. Gourgoulianis, K. Kostikas. (2010) The acute effect of smoking in healthy and asthmatic smokers. European Journal of Clinical Investigation 40:2, 103-109
CrossRef51
Jun-ichi Oyama, Toyoki Maeda, Makoto Sasaki, Kazuya Kozuma, Ryuji Ochiai, Ichiro Tokimitsu, Sachiyo Taguchi, Yoshihiro Higuchi, Naoki Makino. (2010) Green Tea Catechins Improve Human Forearm Vascular Function and Have Potent Anti-Inflammatory and Anti-Apoptotic Effects in Smokers. Internal Medicine 49:23, 2553-2559
CrossRef52
Alan W. Taylor, Maret G. Traber. (2010) Quantitation of plasma total 15-series F2-isoprostanes by sequential solid phase and liquid–liquid extraction. Analytical Biochemistry 396:2, 319-321
CrossRef53
S. Ehrlenbach, P. Willeit, S. Kiechl, J. Willeit, M. Reindl, K. Schanda, F. Kronenberg, A. Brandstatter. (2009) Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. International Journal of Epidemiology 38:6, 1725-1734
CrossRef54
Jane A. Leopold, Joseph Loscalzo. (2009) Oxidative risk for atherothrombotic cardiovascular disease. Free Radical Biology and Medicine 47:12, 1673-1706
CrossRef55
XiangYu Tang, XiangDong Yang, YaFei Peng, JunHua Lin. (2009) Protective Effects of Lycopene against H2O2-Induced Oxidative Injury and Apoptosis in Human Endothelial Cells. Cardiovascular Drugs and Therapy 23:6, 439-448
CrossRef56
R.E. Singer, K. Moss, J.D. Beck, S. Offenbacher. (2009) Association of Systemic Oxidative Stress with Suppressed Serum IgG to Commensal Oral Biofilm and Modulation by Periodontal Infection. Antioxidants & Redox Signaling 11:12, 2973-2983
CrossRef57
Ka H. Chan, Siu P. Ho, Sze C. Yeung, Wallace H.L. So, C.H. Cho, Marcel W.L. Koo, Wah K. Lam, Mary S.M. Ip, Ricky Y.K. Man, Judith C.W. Mak. (2009) Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats. Respiratory Medicine 103:11, 1746-1754
CrossRef58
Francesca Mangialasche, M. Cristina Polidori, Roberto Monastero, Sara Ercolani, Cecilia Camarda, Roberta Cecchetti, Patrizia Mecocci. (2009) Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment. Ageing Research Reviews 8:4, 285-305
CrossRef59
Baher Fahmy, Stephania A. Cormier. (2009) Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicology in Vitro 23:7, 1365-1371
CrossRef60
Martin Unverdorben, Klaus von Holt, Bernhard R Winkelmann. (2009) Smoking and atherosclerotic cardiovascular disease: Part II: Role of cigarette smoking in cardiovascular disease development. Biomarkers in Medicine 3:5, 617-653
CrossRef61
Rebecca M. LeLeiko, Christopher S. Vaccari, Srikanth Sola, Nadya Merchant, Sameer H. Nagamia, Martin Thoenes, Bobby V. Khan. (2009) Usefulness of Elevations in Serum Choline and Free F2-Isoprostane to Predict 30-Day Cardiovascular Outcomes in Patients With Acute Coronary Syndrome. The American Journal of Cardiology 104:5, 638-643
CrossRef62
Serena Tonstad. (2009) Cigarette smoking, smoking cessation, and diabetes. Diabetes Research and Clinical Practice 85:1, 4-13
CrossRef63
I. Tong Mak, Joanna J. Chmielinska, Jay H. Kramer, William B. Weglicki. (2009) AZT-Induced Oxidative Cardiovascular Toxicity: Attenuation by Mg-Supplementation. Cardiovascular Toxicology 9:2, 78-85
CrossRef64
Christian K. Roberts, Kunal K. Sindhu. (2009) Oxidative stress and metabolic syndrome. Life Sciences 84:21-22, 705-712
CrossRef65
Cristina Vassalle, Silvia Maffei, Rudina Ndreu, Antonella Mercuri. (2009) Age-related oxidative stress modulation by smoking habit and obesity. Clinical Biochemistry 42:7-8, 739-741
CrossRef66
Maria Teresa Guagnano, Patrizia Ferroni, Francesca Santilli, Vincenzo Paoletti, Maria Rosaria Manigrasso, Lea Pescara, Chiara Cuccurullo, Giovanni Ciabattoni, Giovanni Davì. (2009) Determinants of platelet activation in hypertensives with microalbuminuria. Free Radical Biology and Medicine 46:7, 922-927
CrossRef67
S. Honarbakhsh, M. Schachter. (2009) Vitamins and cardiovascular disease. British Journal of Nutrition 101:08, 1113
CrossRef68
Subhasis Das, N. Gautam, Sankar Kumar Dey, Tarasankar Maiti, Somenath Roy. (2009) Oxidative stress in the brain of nicotine-induced toxicity: protective role of Andrographis paniculata Nees and vitamin E. Applied Physiology, Nutrition, and Metabolism 34:2, 124-135
CrossRef69
M. Fan, O.T. Raitakari, M. Kähönen, M. Juonala, N. Hutri-Kähönen, I. Pörsti, J. Viikari, T. Lehtimäki. (2009) The Association Between Cigarette Smoking and Carotid Intima–Media Thickness Is Influenced by the −930A/G CYBA Gene Polymorphism: The Cardiovascular Risk in Young Finns Study. American Journal of Hypertension 22:3, 281-287
CrossRef70
Chung-Yung J. Lee, Raymond C.S. Seet, Shan Hong Huang, Lee Hua Long, Barry Halliwell. (2009) Different Patterns of Oxidized Lipid Products in Plasma and Urine of Dengue Fever, Stroke, and Parkinson's Disease Patients: Cautions in the Use of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling 11:3, 407-420
CrossRef71
Ramkumar Menon, Stephen J. Fortunato. (2009) Distinct pathophysiologic pathways induced by in vitro infection and cigarette smoke in normal human fetal membranes. American Journal of Obstetrics and Gynecology 200:3, 334.e1-334.e8
CrossRef72
Joshua A. Sonnen, Eric B. Larson, Shelly L. Gray, Angela Wilson, Steven G. Kohama, Paul K. Crane, John C. S. Breitner, Thomas J. Montine. (2009) Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Annals of Neurology 65:2, 226-229
CrossRef73
Deepak K. Bhalla, Fusao Hirata, Arun K. Rishi, C. Gary Gairola. (2009) Cigarette Smoke, Inflammation, and Lung Injury: A Mechanistic Perspective. Journal of Toxicology and Environmental Health, Part B 12:1, 45-64
CrossRef74
Alessandra Binazzi, Stefano Belli, Raffaella Uccelli, Maria Teresa Desiato, Irene Figà Talamanca, Giovanni Antonini, Fabio M. Corsi, Ciriaco Scoppetta, Maurizio Inghilleri, Francesco E. Pontieri, Nicola Vanacore, ALS Rome Group. (2009) An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome. Amyotrophic Lateral Sclerosis 10:5-6, 361-369
CrossRef75
R. J. Bloomer, K. Fisher-Wellman. (2009) The role of exercise in minimizing postprandial oxidative stress in cigarette smokers. Nicotine & Tobacco Research
CrossRef76
Hapidin Hermizi, Othman Faizah, Soelaiman Ima-Nirwana, Shuid Ahmad Nazrun, Mohamed Norazlina. (2009) Beneficial Effects of Tocotrienol and Tocopherol on Bone Histomorphometric Parameters in Sprague–Dawley Male Rats After Nicotine Cessation. Calcified Tissue International 84:1, 65-74
CrossRef77
Hee Sun PARK, So Ri KIM, Yong Chul LEE. (2009) Impact of oxidative stress on lung diseases. Respirology 14:1, 27-38
CrossRef78
Irfan Rahman. 2009. Reactive Oxygen Species and Antioxidant Therapeutic Approaches. , 293-312.
CrossRef79
Minoru Sugiura, Mieko Nakamura, Kazunori Ogawa, Yoshinori Ikoma, Hikaru Matsumoto, Fujiko Ando, Hiroshi Shimokata, Masamichi Yano. (2008) Associations of serum carotenoid concentrations with the metabolic syndrome: interaction with smoking. British Journal of Nutrition 100:06, 1297
CrossRef80
Ines Unterwurzacher, Therese Koal, Guenther K. Bonn, Klaus M. Weinberger, Steven L. Ramsay. (2008) Rapid sample preparation and simultaneous quantitation of prostaglandins and lipoxygenase derived fatty acid metabolites by liquid chromatography-mass spectrometry from small sample volumes. Clinical Chemistry and Laboratory Medicine 46:11, 1589-1597
CrossRef81
P.-Y. LIU, C.-C. LIN, W.-C. TSAI, Y.-H. LI, L.-J. LIN, G.-Y. SHI, J.-S. HONG, J.-H. CHEN, H.-L. WU. (2008) Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers. Journal of Thrombosis and Haemostasis 6:10, 1685-1692
CrossRef82
Alan W. Taylor, Richard S. Bruno, Maret G. Traber. (2008) Women and Smokers Have Elevated Urinary F2-Isoprostane Metabolites: A Novel Extraction and LC–MS Methodology. Lipids 43:10, 925-936
CrossRef83
Na-Ping Tang, Lian-Sheng Wang, Li Yang, Hai-Juan Gu, Qing-Min Sun, Ri-Hong Cong, Bo Zhou, Huai-Jun Zhu, Bin Wang. (2008) Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population. Clinica Chimica Acta 395:1-2, 89-93
CrossRef84
M. Cesari, M. Pahor. (2008) Target population for clinical trials on sarcopenia. The Journal of Nutrition Health and Aging 12:7, 470-478
CrossRef85
Samar Basu. (2008) F 2 -Isoprostanes in Human Health and Diseases: From Molecular Mechanisms to Clinical Implications. Antioxidants & Redox Signaling 10:8, 1405-1434
CrossRef86
Shinobu Hosokawa, Yoshikazu Hiasa, Shinichiro Miyazaki, Riyo Ogura, Hitoshi Miyajima, Yoshikazu Ohara, Kenichiro Yuba, Naoki Suzuki, Takefumi Takahashi, Koichi Kishi, Ryuji Ohtani. (2008) Effects of smoking cessation on coronary endothelial function in patients with recent myocardial infarction. International Journal of Cardiology 128:1, 48-52
CrossRef87
Ullrich Jahn, Jean-Marie Galano, Thierry Durand. (2008) Jenseits von Prostaglandinen - Chemie und Biologie radikalisch gebildeter cyclischer oxygenierter Metabolite von mehrfach ungesättigten Fettsäuren. Angewandte Chemie 120:32, 5978-6041
CrossRef88
Ullrich Jahn, Jean-Marie Galano, Thierry Durand. (2008) Beyond Prostaglandins-Chemistry and Biology of Cyclic Oxygenated Metabolites Formed by Free-Radical Pathways from Polyunsaturated Fatty Acids. Angewandte Chemie International Edition 47:32, 5894-5955
CrossRef89
Hari K. Dandapantula, J. Richard Spears, Laxmana Chandu, Hima Katkuri, Luis Afonso. (2008) Cigarette smoking and myocardial infarction in young men and women — “Let us not forget coronary vasospasm”. International Journal of Cardiology 127:3, 402
CrossRef90
Gerasimos Siasos, Dimitris Tousoulis, Charalambos Vlachopoulos, Charalambos Antoniades, Elli Stefanadi, Nikos Ioakeimidis, Ioannis Andreou, Kostas Zisimos, Athanasios G Papavassiliou, Christodoulos Stefanadis. (2008) Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. International Journal of Cardiology 126:3, 394-399
CrossRef91
Hayden McRobbie, Simon Thornley. (2008) La importancia de tratar la dependencia tabáquica. Revista Española de Cardiología 61:6, 620-628
CrossRef92
Richard J. Bloomer, Adrienne D. Solis, Kelsey H. Fisher-Wellman, Webb A. Smith. (2008) Postprandial oxidative stress is exacerbated in cigarette smokers. British Journal of Nutrition 99:05,
CrossRef93
MaryFran Sowers, Daniel McConnell, Mary L. Jannausch, John F. Randolph, Robert Brook, Ellen B. Gold, Sybil Crawford, Bill Lasley. (2008) Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress. Clinical Endocrinology 68:5, 806-813
CrossRef94
P. Faure, C. Polge, D. Monneret, A. Favier, S. Halimi. (2008) Plasma 15-F2t isoprostane concentrations are increased during acute fructose loading in type 2 diabetes. Diabetes & Metabolism 34:2, 148-154
CrossRef95
Chung-Yung J. Lee, Shan Hong Huang, Andrew M. Jenner, Barry Halliwell. (2008) Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. Free Radical Biology and Medicine 44:7, 1314-1322
CrossRef96
Bonnie Ky, Anne Burke, Sotirios Tsimikas, Megan L. Wolfe, Mahlet G. Tadesse, Philippe O. Szapary, Joseph L. Witztum, Garret A. FitzGerald, Daniel J. Rader. (2008) The Influence of Pravastatin and Atorvastatin on Markers of Oxidative Stress in Hypercholesterolemic Humans. Journal of the American College of Cardiology 51:17, 1653-1662
CrossRef97
Sachchida Nand Pandey, Gourdas Choudhuri, Balraj Mittal. (2008) Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. European Journal of Cancer Prevention 17:2, 77-81
CrossRef98
H.-C. Wu, Q. Wang, H.-I Yang, H. Ahsan, W.-Y. Tsai, L.-Y. Wang, S.-Y. Chen, C.-J. Chen, R. M. Santella. (2008) Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan. Carcinogenesis 29:5, 971-976
CrossRef99
Lena Lavie, Peretz Lavie. (2008) Smoking interacts with sleep apnea to increase cardiovascular risk. Sleep Medicine 9:3, 247-253
CrossRef100
Pierre Astorg, Aline Couthouis, Sandrine Bertrais, Nathalie Arnault, Pierre Meneton, Philippe Guesnet, Jean-Marc Alessandri, Pilar Galan, Serge Hercberg. (2008) Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women. Prostaglandins, Leukotrienes and Essential Fatty Acids 78:3, 171-182
CrossRef101
Chih-Ching Yeh, R. Graham Barr, Charles A. Powell, Sonia Mesia-Vela, Yuanjia Wang, Nada K. Hamade, John H.M. Austin, Regina M. Santella. (2008) No effect of cigarette smoking dose on oxidized plasma proteins. Environmental Research 106:2, 219-225
CrossRef102
Mario Comporti, Cinzia Signorini, Beatrice Arezzini, Daniela Vecchio, Barbara Monaco, Concetta Gardi. (2008) F2-isoprostanes are not just markers of oxidative stress. Free Radical Biology and Medicine 44:3, 247-256
CrossRef103
Jeffrey W. Stephens, Sukhbir S. Dhamrait, Ali R. Mani, Jayshree Acharya, Kevin Moore, Steven J. Hurel, Steve E. Humphries. (2008) Interaction between the uncoupling protein 2 −866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes. Nutrition, Metabolism and Cardiovascular Diseases 18:1, 7-14
CrossRef104
Huiyong Yin. (2008) New techniques to detect oxidative stress markers: Mass spectrometry-based methods to detect isoprostanes as the gold standard for oxidative stress in vivo. BioFactors 34:2, 109-124
CrossRef105
Sonia Mesia-Vela, Chih-Ching Yeh, John H.M. Austin, Matthew Dounel, Charles A. Powell, Anthony Reeves, Regina M. Santella, Lori Stevenson, David Yankelevitz, R. Graham Barr. (2008) Plasma carbonyls do not correlate with lung function or computed tomography measures of lung density in older smokers. Biomarkers 13:4, 422-434
CrossRef106
Sevim Sureyya Cerci, Onder Ozturk, Recep Sutcu, Feride Meltem Ozbek, Cetin Lutfi Baydar, Mustafa Yildiz, Ahmet Akkaya, Namk Delibas. (2008) Evaluation of the effects of toluene inhalation on alveolar epithelial permeability by 99mTc-DTPA inhalation scintigraphy in automobile painters. Nuclear Medicine Communications 29:1, 45-52
CrossRef107
Larry C. Lands. (2007) Nutrition in pediatric lung disease. Paediatric Respiratory Reviews 8:4, 305-312
CrossRef108
I. M. E. Wentholt, W. Kulik, R. P. J. Michels, J. B. L Hoekstra, J. H. DeVries. (2007) Glucose fluctuations and activation of oxidative stress in patients with type 1 diabetes. Diabetologia 51:1, 183-190
CrossRef109
James C. Oates, Libby W. Farrelly, Ann F. Hofbauer, Wei Wang, Gary S. Gilkeson. (2007) Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients. Arthritis & Rheumatism 56:11, 3738-3747
CrossRef110
V. Medina-Hernández, J. Ramos-Loyo, S. Luquin, L.F. Cerdán Sánchez, J. García-Estrada, A. Navarro-Ruiz. (2007) Increased lipid peroxidation and neuron specific enolase in treatment refractory schizophrenics. Journal of Psychiatric Research 41:8, 652-658
CrossRef111
Connie Chen, Mehrdad Arjomandi, John Balmes, Ira Tager, Nina Holland. (2007) Effects of Chronic and Acute Ozone Exposure on Lipid Peroxidation and Antioxidant Capacity in Healthy Young Adults. Environmental Health Perspectives 115:12, 1732-1737
CrossRef112
William MacNee. (2007) Pathogenesis of Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 28:3, 479-513
CrossRef113
Ginger Milne, Ling Gao, Joshua Brooks, Jason Morrow. 2007. The Role of Oxidative Stress in Diseases Associated with Overweight and Obesity. , 33-46.
CrossRef114
Einat Gochman, Abraham Z. Reznick, Ophir Avizohar, Ami Ben-amotz, Yishai Levy. (2007) Exhaustive Exercise Modifies Oxidative Stress in Smoking Subjects. The American Journal of the Medical Sciences 333:6, 346-353
CrossRef115
Kyung-Jin Yeum, Norman I. Krinsky. 2007. Antioxidative Effects of Carotenoids. , 271-290.
CrossRef116
Hiroyuki Kobori, Akemi Katsurada, Yuri Ozawa, Ryousuke Satou, Kayoko Miyata, Naoki Hase, Yuki Suzaki, Tatsuya Shoji. (2007) Enhanced intrarenal oxidative stress and angiotensinogen in IgA nephropathy patients. Biochemical and Biophysical Research Communications 358:1, 156-163
CrossRef117
David O. Warner. (2007) Tobacco control for anesthesiologists. Journal of Anesthesia 21:2, 200-211
CrossRef118
Lena LAVIE, Alona VISHNEVSKY, Peretz LAVIE. (2007) Oxidative stress and systemic inflammation in patients with sleep apnea: Role of obesity. Sleep and Biological Rhythms 5:2, 100-110
CrossRef119
Carlos Mercado, Edgar A. Jaimes. (2007) Cigarette smoking as a risk factor for atherosclerosis and renal disease: Novel pathogenic insights. Current Hypertension Reports 9:1, 66-72
CrossRef120
Elisa Cebral, Alicia Faletti, Alicia Jawerbaum, Dante Paz. (2007) Periconceptional alcohol consumption-induced changes in embryonic prostaglandin E levels in mouse organogenesis: Modulation by nitric oxide. Prostaglandins, Leukotrienes and Essential Fatty Acids 76:3, 141-151
CrossRef121
Andrew E. Ajani, Bryan P. Yan. (2007) The Mystery of Coronary Artery Spasm. Heart, Lung and Circulation 16:1, 10-15
CrossRef122
Yasuaki Dohi, Hiroyuki Takase, Koichi Sato, Ryuzo Ueda. (2007) Association among C-reactive protein, oxidative stress, and traditional risk factors in healthy Japanese subjects. International Journal of Cardiology 115:1, 63-66
CrossRef123
Laura Núñez-Naveira, Carmen Montero-Martínez, David Ramos-Barbón. (2007) Oxidación, inflamación y modificaciones estructurales. Archivos de Bronconeumología 43, 18-29
CrossRef124
Cevat Kirma, Mustafa Akcakoyun, Ali Metin Esen, Irfan Barutcu, Osman Karakaya, Mustafa Saglam, Ramazan Kargin, Muhsin Turkmen, Bilal Boztosun, Akin Izgi, Kenan Sonmez. (2007) Relationship Between Endothelial Function and Coronary Risk Factors in Patients With Stable Coronary Artery Disease. Circulation Journal 71:5, 698-702
CrossRef125
Yoshiaki Takeshita, Yoshio Katsuki, Yousuke Katsuda, Hisashi Kai, Yutaka Saito, Ken Arima, Ken-ichiro Sasaki, Tsutomu Imaizumi. (2007) Vitamin C Reversed Malfunction of Peripheral Blood-Derived Mononuclear Cells in Smokers Through Antioxidant Properties. Circulation Journal 72:4, 654-659
CrossRef126
Mehdi H. Shishehbor, Renliang Zhang, Hector Medina, Marie-Luise Brennan, Danielle M. Brennan, Stephen G. Ellis, Eric J. Topol, Stanley L. Hazen. (2006) Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease. Free Radical Biology and Medicine 41:11, 1678-1683
CrossRef127
Masayoshi Konishi, Motoh Iwasa, Jun Araki, Yoshinao Kobayashi, Akira Katsuki, Yasuhiro Sumida, Naoki Nakagawa, Yuji Kojima, Shozo Watanabe, Yukihiko Adachi, Masahiko Kaito. (2006) Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane. Journal of Gastroenterology and Hepatology 21:12, 1821-1825
CrossRef128
Alessandro Assisi, Rita Banzi, Carmela Buonocore, Filippo Capasso, Valeria Di Muzio, Francesca Michelacci, Danila Renzo, Giovanni Tafuri, Francesco Trotta, Maria Vitocolonna, Silvio Garattini. (2006) Fish oil and mental health: the role of n-3 long-chain polyunsaturated fatty acids in cognitive development and neurological disorders. International Clinical Psychopharmacology 21:6, 319-336
CrossRef129
Masahiko Kaito, Motoh Iwasa, Yoshinao Kobayashi, Naoki Fujita, Hideaki Tanaka, Esteban C. Gabazza, Yukihiko Adachi, Yuji Kojima, Naoki Nakagawa, Shozo Watanabe. (2006) Iron reduction therapy by phlebotomy reduces lipid peroxidation and oxidative stress in patients with chronic hepatitis C. Journal of Gastroenterology 41:9, 921-922
CrossRef130
Parri Wentzel, Ulf Rydberg, Ulf J. Eriksson. (2006) Antioxidative Treatment Diminishes Ethanol-Induced Congenital Malformations in the Rat. Alcoholism: Clinical and Experimental Research 30:10, 1752-1760
CrossRef131
Jean-Luc Cracowski, Thierry Durand. (2006) Cardiovascular pharmacology and physiology of the isoprostanes. Fundamental and Clinical Pharmacology 20:5, 417-427
CrossRef132
Lisa G Wood, Peter G Gibson, Manohar L Garg. (2006) A review of the methodology for assessingin vivo antioxidant capacity. Journal of the Science of Food and Agriculture 86:13, 2057-2066
CrossRef133
Todd Hulgan, Michael Hughes, Xin Sun, Laura M. Smeaton, Erin Terry, Gregory K. Robbins, Robert W. Shafer, David B. Clifford, Grace A. McComsey, Jeffery A. Canter, Jason D. Morrow, David W. Haas. (2006) Oxidant Stress and Peripheral Neuropathy During Antiretroviral Therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes 42:4, 450-454
CrossRef134
Paul Kirkham, Irfan Rahman. (2006) Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy. Pharmacology & Therapeutics 111:2, 476-494
CrossRef135
Esther Ardite, Víctor I. Peinado, Roberto A. Rabinovich, José C. Fernández-Checa, Josep Roca, Joan A. Barberà. (2006) Systemic effects of cigarette smoke exposure in the guinea pig. Respiratory Medicine 100:7, 1186-1194
CrossRef136
Rodica Pop-Busui, Anders Sima, Martin Stevens. (2006) Diabetic neuropathy and oxidative stress. Diabetes/Metabolism Research and Reviews 22:4, 257-273
CrossRef137
Anna R. Proteggente, Cristina Rota, John Majewicz, Gerald Rimbach, Anne Marie Minihane, Klaus Kraemer, John K. Lodge. (2006) Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) α-tocopherol: A biokinetic study in apoE4 male subjects. Free Radical Biology and Medicine 40:12, 2080-2091
CrossRef138
Khaled AL-Menabbawy ., Mona Sallam ., Safaa Taha ., Hesham Mottawie ., Atef Ibrahiem .. (2006) Obesity, Sedentary Lifestyle and Oxidative Stress among Young Adolescent. Journal of Medical Sciences(Faisalabad) 6:6, 956-961
CrossRef139
Annida Balakrishnan ., Venugopal P. Menon .. (2006) Role of Hesperidin on Nictotine Toxicity. International Journal of Pharmacology 2:6, 664-669
CrossRef140
Chung-Yung J. Lee, Helen B. Isaac, Huansong Wang, Shan Hong Huang, Lee-Hua Long, Andrew M. Jenner, Ronan P. Kelly, Barry Halliwell. (2006) Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humans. Biochemical and Biophysical Research Communications 344:3, 906-911
CrossRef141
G.D. Kom, E. Schwedhelm, P. Nielsen, R.H. Böger. (2006) Increased urinary excretion of 8-iso-prostaglandin F2α in patients with HFE-related hemochromatosis: A case-control study. Free Radical Biology and Medicine 40:7, 1194-1200
CrossRef142
Christopher S. Stevenson, Lauren Gerard Koch, Steven L. Britton. (2006) Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease—A new take on an old hypothesis. Pharmacology & Therapeutics 110:1, 71-82
CrossRef143
Matteo Cesari, Stephen B. Kritchevsky, Christiaan Leeuwenburgh, Marco Pahor. (2006) Oxidative Damage and Platelet Activation as New Predictors of Mobility Disability and Mortality in Elders. Antioxidants & Redox Signaling 8:3-4, 609-619
CrossRef144
Huiyong Yin ., Erik S. Musiek ., Jason D. Morrow .. (2006) Quantification of Isoprostanes as an Index of Oxidative Stress: A Update. Journal of Biological Sciences 6:3, 469-479
CrossRef145
Lene Frost Andersen, David R Jacobs, Myron D. Gross, Pamela J. Schreiner, O. Dale Williams, Duk-Hee Lee. (2006) Longitudinal associations between body mass index and serum carotenoids: the CARDIA study. British Journal of Nutrition 95:02, 358
CrossRef146
Graeme J Hankey, John W Eikelboom. (2006) Aspirin resistance. The Lancet 367:9510, 606-617
CrossRef147
Marietta Charakida, John E. Deanfield, Julian P. J. Halcox. (2006) The role of nitric oxide in early atherosclerosis. European Journal of Clinical Pharmacology 62:S1, 69-78
CrossRef148
Richard S. Bruno, Scott W. Leonard, Jeffery Atkinson, Thomas J. Montine, Rajasekhar Ramakrishnan, Tammy M. Bray, Maret G. Traber. (2006) Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radical Biology and Medicine 40:4, 689-697
CrossRef149
David O. Warner. (2006) Perioperative Abstinence from Cigarettes. Anesthesiology 104:2, 356-367
CrossRef150
Ahmad A. Elesber, Ahmad A. Elesber, Patricia J. Best, Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Verghese Mathew, Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Verghese Mathew, Charanjit S. Rihal, Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Verghese Mathew, Charanjit S. Rihal, Lilach O. Lerman, Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Verghese Mathew, Charanjit S. Rihal, Lilach O. Lerman, Amir Lerman, Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Verghese Mathew, Charanjit S. Rihal, Lilach O. Lerman, Amir Lerman. (2006) Plasma 8-iso-prostaglandin F 2α , a marker of oxidative stress, is increased in patients with acute myocardial infarction. Free Radical Research 40:4, 385-391
CrossRef151
Leszek Tylicki, Heidemarie Puttinger, Przemyslaw Rutkowski, Boleslaw Rutkowski, Walter H. Hörl. (2006) Smoking as a Risk Factor for Renal Injury in Essential Hypertension. Nephron Clinical Practice 103:4, c121-c128
CrossRef152
Koichi Fujita, Hitoshi Nishizawa, Tohru Funahashi, Iichiro Shimomura, Michio Shimabukuro. (2006) Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome. Circulation Journal 70:11, 1437-1442
CrossRef153
Samar Basu. (2006) F 2 -isoprostane induced prostaglandin formation in the rabbit. Free Radical Research 40:3, 273-277
CrossRef154
Joanna M. Young, Brett I. Shand, Patrice M. McGregor, Russell S. Scott, Christopher M. Frampton. (2006) Comparative effects of enzogenol ® and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Free Radical Research 40:1, 85-94
CrossRef155
Ryuichi Kawamoto, Hitomi Tomita, Yuichiro Oka, Nobuyuki Ohtsuka. (2006) Relationship between Serum Uric Acid Concentration, Metabolic Syndrome and Carotid Atherosclerosis. Internal Medicine 45:9, 605-614
CrossRef156
Halil Tanriverdi, Harun Evrengul, Omur Kuru, Seyhan Tanriverdi, Deniz Seleci, Yasar Enli, H Asuman Kaftan, Mustafa Kilic. (2006) Cigarette Smoking Induced Oxidative Stress may Impair Endothelial Function and Coronary Blood Flow in Angiographically Normal Coronary Arteries. Circulation Journal 70:5, 593-599
CrossRef157
Okezie I. Aruoma, Buxiang Sun, Hajime Fujii, Vidushi S. Neergheen, Theeshan Bahorun, Kyung-Sun Kang, Mi-Kyung Sung. (2006) Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials. BioFactors 27:1-4, 245-265
CrossRef158
Fumihide OGAWA, Shinichi SATO. (2006) Roles of oxidative stress in photoaging and the pathogenesis of systemic sclerosis. Japanese Journal of Clinical Immunology 29:6, 349-358
CrossRef159
Roswitha M. Wolfram, Alexandra C. Budinsky, Andreas Eder, Christiane Presenhuber, Andrea Nell, Wolfgang Sperr, Helmut Sinzinger. (2006) Salivary isoprostanes indicate increased oxidation injury in periodontitis with additional tobacco abuse. BioFactors 28:1, 21-31
CrossRef160
Hossein Ahmadzadehfar, Anthony Oguogho, Yannis Efthimiou, Harald Kritz, Helmut Sinzinger. (2006) Passive cigarette smoking increases isoprostane formation. Life Sciences 78:8, 894-897
CrossRef161
H.A.C. van Helvoort, Y.F. Heijdra, P.N.R. Dekhuijzen. (2006) Systemic Immunological Response to Exercise in Patients with Chronic Obstructive Pulmonary Disease: What Does It Mean?. Respiration
CrossRef162
Masao Sato, Kenichi Shibata, Run Nomura, Daisuke Kawamoto, Rika Nagamine, Katsumi Imaizumi. (2005) Linoleic acid-rich fats reduce atherosclerosis development beyond its oxidative and inflammatory stress-increasing effect in apolipoprotein E-deficient mice in comparison with saturated fatty acid-rich fats. British Journal of Nutrition 94:06, 896
CrossRef163
Jonathan Majewicz, Gerald Rimbach, Anna R. Proteggente, John K. Lodge, Klaus Kraemer, Anne M. Minihane. (2005) Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers. Biochemical and Biophysical Research Communications 338:2, 951-955
CrossRef164
Juan Carlos Yugar-Toledo, Sílvia Elaine Ferreira-Melo, Maricene Sabha, Eduardo Arantes Nogueira, Otávio Rizzi Coelho, Fernanda Marciano Consolin, Maria Claudia Irigoyen, Heitor Moreno. (2005) Blood Pressure Circadian Rhythm and Endothelial Function in Heavy Smokers: Acute Effects of Transdermal Nicotine. The Journal of Clinical Hypertension 7:12, 721-728
CrossRef165
Nalan Çiçek Özdöl, Aşkın Ateş, Olcay Tiryaki Aydıntuğ, Mehmet Melli. (2005) Urinary 8-isoprostaglandin F2α level in Behçet's disease. Prostaglandins & Other Lipid Mediators 78:1-4, 96-106
CrossRef166
Jennifer L. Donovan, Lindsay Vane, Kenneth D. Chavin, Ryan N. Fiorini, James C. Oates, Chinedu Njoku, Kennerly S. Patrick, John S. Markowitz. (2005) Oral administration of a decaffeinated green tea (Camellia sinensis ) extract did not alter urinary 8-epi-prostaglandin F 2α , a biomarker for in-vivo lipid peroxidation. Journal of Pharmacy and Pharmacology 57:10, 1365-1369
CrossRef167
Erik S. Musiek, Huiyong Yin, Ginger L. Milne, Jason D. Morrow. (2005) Recent advances in the biochemistry and clinical relevance of the isoprostane pathway. Lipids 40:10, 987-994
CrossRef168
T. Heitzer, T. Meinertz. (2005) Rauchen und koronare Herzkrankheit. Zeitschrift für Kardiologie 94:S3, iii30-iii42
CrossRef169
D. Chan. (2005) Effect of ascorbic acid supplementation on plasma isoprostanes in haemodialysis patients. Nephrology Dialysis Transplantation 21:1, 234-235
CrossRef170
Yongde Zhang, Evi Pertens, Luke J. Janssen. (2005) 8-isoprostaglandin E2 activates Ca2+-dependent K+ current via cyclic AMP signaling pathway in murine renal artery. European Journal of Pharmacology 520:1-3, 22-28
CrossRef171
Ahamed H. Idris, L Jackson Roberts, Lawrence Caruso, Mary Showstark, A Joseph Layon, Lance B. Becker, Terry Vanden Hoek, Andrea Gabrielli. (2005) Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusion*. Critical Care Medicine 33:9, 2043-2048
CrossRef172
R. STOCKER, J. F. KEANEY. (2005) New insights on oxidative stress in the artery wall. Journal of Thrombosis and Haemostasis 3:8, 1825-1834
CrossRef173
A. Barceló, F. Barbé. (2005) Estrés oxidativo y síndrome de apneas-hipopneas del sueño. Archivos de Bronconeumología 41:7, 393-399
CrossRef174
B. Vaona, A.M. Stanzial, G. Talamini, P. Bovo, R. Corrocher, G. Cavallini. (2005) Serum selenium concentrations in chronic pancreatitis and controls. Digestive and Liver Disease 37:7, 522-525
CrossRef175
J. Helmersson, A. Larsson, B. Vessby, S. Basu. (2005) Active smoking and a history of smoking are associated with enhanced prostaglandin F2α, interleukin-6 and F2-isoprostane formation in elderly men. Atherosclerosis 181:1, 201-207
CrossRef176
John K Lodge. (2005) Vitamin E bioavailability in humans. Journal of Plant Physiology 162:7, 790-796
CrossRef177
Erik S. Musiek, Jason D. Morrow. 2005. F 2 -Isoprostanes as Markers of Oxidant Stress: An Overview. .
CrossRef178
Richard W. James, Barbara Kalix, Silvana Bioletto, Marie-Claude Brulhart-Meynet. (2005) Paraoxonase-1 promoter polymorphism C???107T and serum apolipoprotein AI interact to modulate serum paraoxonase-1 status. Pharmacogenetics and Genomics 15:6, 441-446
CrossRef179
Atsuhiro Ichihara, Matsuhiko Hayashi, Yuki Kaneshiro, Tomoko Takemitsu, Koichiro Homma, Yoshihiko Kanno, Mamoru Yoshizawa, Tomohiro Furukawa, Tsuneo Takenaka, Takao Saruta. (2005) Low Doses of Losartan and Trandolapril Improve Arterial Stiffness in Hemodialysis Patients. American Journal of Kidney Diseases 45:5, 866-874
CrossRef180
J. Nourooz-Zadeh, M.B. Cooper, D. Ziegler, D.J. Betteridge. (2005) Urinary 8-epi-PGF2α and its endogenous β-oxidation products (2,3-dinor and 2,3-dinor-5,6-dihydro) as biomarkers of total body oxidative stress. Biochemical and Biophysical Research Communications 330:3, 731-736
CrossRef181
Marcio Goncalves de SOUSA, Juan Carlos YUGAR-TOLEDO, Marcelo RUBIRA, Silvia Elaine FERREIRA-MELO, Rodrigo PLENTZ, Deise BARBIERI, Fernanda CONSOLIM-COLOMBO, Maria Claudia IRIGOYEN, Heitor MORENO. (2005) Ascorbic acid improves impaired venous and arterial endothelium-dependent dilation in smokers1. Acta Pharmacologica Sinica 26:4, 447-452
CrossRef182
Marion Dietrich, Youqing Hu, Gladys Block, Estibaliz Olano, Lester Packer, Jason D. Morrow, Mark Hudes, Gulbahar Abdukeyum, Gerald Rimbach, Anne M. Minihane. (2005) Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans. Lipids 40:4, 329-334
CrossRef183
J. Helmersson, B. Vessby, A. Larsson, S. Basu. (2005) Cyclooxygenase-mediated prostaglandin F2α is decreased in an elderly population treated with low-dose aspirin. Prostaglandins, Leukotrienes and Essential Fatty Acids 72:4, 227-233
CrossRef184
Jeffrey A. Canter, Alex Eshaghian, Joshua Fessel, Marshall L. Summar, Jackson L. Roberts, Jason D. Morrow, James E. Sligh, Jonathan L. Haines. (2005) Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation. Free Radical Biology and Medicine 38:5, 678-683
CrossRef185
Hirohiko Morita, Hisao Ikeda, Nobuya Haramaki, Hiroyuki Eguchi, Tsutomu Imaizumi. (2005) Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers. Journal of the American College of Cardiology 45:4, 589-594
CrossRef186
Jaakko Mursu, Sari Voutilainen, Tarja Nurmi, Georg Alfthan, Jyrki K. Virtanen, Tiina H. Rissanen, Pertti Happonen, Kristiina Nyyssönen, Jari Kaikkonen, Riitta Salonen, Jukka T. Salonen. (2005) The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial. Free Radical Biology and Medicine 38:4, 527-534
CrossRef187
Ahmed Nadeem, Hanumanthrao Guru Raj, Sunil Kumar Chhabra. (2005) Increased Oxidative Stress and Altered Levels of Antioxidants in Chronic Obstructive Pulmonary Disease. Inflammation 29:1, 23-32
CrossRef188
Junko Mashiba, George Koike, Hitoshi Kamiunten, Manami Ikeda, Kenji Sunagawa. (2005) Vasospastic Angina and Microvascular Angina are Differentially Influenced by PON1 A632G Polymorphism in the Japanese. Circulation Journal 69:12, 1466-1471
CrossRef189
Peter J. O'Brien, Arno G. Siraki, Nandita Shangari. (2005) Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health. Critical Reviews in Toxicology 35:7, 609-662
CrossRef190
Kunihisa Miwa, Chiharu Kishimoto, Hajime Nakamura, Toshinori Makita, Katsuhisa Ishii, Nobuaki Okuda, Junji Yodoi, Shigetake Sasayama. (2005) Serum Thioredoxin and α-Tocopherol Concentrations in Patients With Major Risk Factors. Circulation Journal 69:3, 291-294
CrossRef191
Irfan Rahman. (2005) The Role of Oxidative Stress in the Pathogenesis??of COPD. Treatments in Respiratory Medicine 4:3, 175-200
CrossRef192
Samar Basu, Johanna Helmersson. (2005) Factors Regulating Isoprostane Formation In Vivo. Antioxidants & Redox Signaling 7:1-2, 221-235
CrossRef193
Markus B??chir, Frank Enseleit, R??my Chenevard, J??rg Muntwyler, Thomas F. L??scher, Georg Noll. (2005) Folic Acid Improves Baroreceptor Sensitivity in Hypertension. Journal of Cardiovascular Pharmacology 45:1, 44-48
CrossRef194
Kaori Ohmori, Satoru Ebihara, Shinichi Kuriyama, Takashi Ugajin, Mikiko Ogata, Atsushi Hozawa, Toshifumi Matsui, Yoshitaka Tsubono, Hiroyuki Arai, Hidetada Sasaki, Ichiro Tsuji. (2005) The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community. Annals of Epidemiology 15:1, 80-84
CrossRef195
Ginger L. Milne, Erik S. Musiek, Jason D. Morrow. (2005) F 2 -Isoprostanes as markers of oxidative stress in vivo : An overview. Biomarkers 10:s1, 10-23
CrossRef196
Stojan Jovelic, Zoran Hajdukovic, Aleksandra Jovelic, Slavica Radjen. (2005) Cigarette smoking in military pilots and intima-media thickness of the carotid arteries. Vojnosanitetski pregled 62:5, 365-370
CrossRef197
J. Sowell, B. Frei, J. F. Stevens. (2004) Vitamin C conjugates of genotoxic lipid peroxidation products: Structural characterization and detection in human plasma. Proceedings of the National Academy of Sciences 101:52, 17964-17969
CrossRef198
V. Menon, M. Ram, J. Dorn, D. Armstrong, P. Muti, J. L. Freudenheim, R. Browne, H. Schunemann, M. Trevisan. (2004) Oxidative stress and glucose levels in a population-based sample. Diabetic Medicine 21:12, 1346-1352
CrossRef199
A.G. Rumley. (2004) Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease. QJM 97:12, 809-816
CrossRef200
Gang Chen, Lance K. Heilbrun, Raghu Venkatramanamoorthy, Vera Maranci, Jennifer N. Redd, David M. Klurfeld, Zora Djuric. (2004) Effects of Low-Fat and/or High Fruit-and-Vegetable Diets on Plasma Levels of 8-Isoprostane-F 2α in the Nutrition and Breast Health Study. Nutrition and Cancer 50:2, 155-160
CrossRef201
Takuro Koga, Paul Kwan, Ligia Zubik, Clement Ameho, Donald Smith, Mohsen Meydani. (2004) Vitamin E supplementation suppresses macrophage accumulation and endothelial cell expression of adhesion molecules in the aorta of hypercholesterolemic rabbits. Atherosclerosis 176:2, 265-272
CrossRef202
T. Mueller, B. Dieplinger, A. Gegenhuber, D. Haidinger, N. Schmid, N. Roth, F. Ebner, M. Landl, W. Poelz, M. Haltmayer. (2004) Serum total 8-iso-prostaglandin F2α: A new and independent predictor of peripheral arterial disease. Journal of Vascular Surgery 40:4, 768-773
CrossRef203
Alessia Pepe, Massimo Lombardi, Imola Takacs, Vincenzo Positano, Gaetano Panzarella, Eugenio Picano. (2004) Nitrate-induced coronary vasodilation by stress-magnetic resonance imaging: A novel noninvasive test of coronary vasomotion. Journal of Magnetic Resonance Imaging 20:3, 390-394
CrossRef204
Kyung Mee Kim, Ki-Jung Paeng, Jong Ryeal Hahm, Deok Ryong Kim, Bong Chul Chung. (2004) Elevated urinary 8-isoprostaglandin F2α in females with Graves’ hyperthyroidism. Prostaglandins, Leukotrienes and Essential Fatty Acids 71:3, 143-147
CrossRef205
I Karamouzis, K Christoulas, D Grekas, Kl Giannoulis, E Vamvakoudis, K Mandroukas. (2004) The response of muscle interstitial F2-isoprostane (8-ISO-PGF2α) during dynamic muscle contractions in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids 71:2, 87-90
CrossRef206
Philip W. Pemberton, Ali Aboutwerat, Alexander Smith, Peter C. Burrows, Raymond F.T. McMahon, Thomas W. Warnes. (2004) Oxidant stress in type I autoimmune hepatitis: the link between necroinflammation and fibrogenesis?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1689:3, 182-189
CrossRef207
Cengiz Akarsu, Bulent Yazici, Pelin Taner, Ahmet Ergin. (2004) Effects of moderate smoking on the central visual field. Acta Ophthalmologica Scandinavica 82:4, 432-435
CrossRef208
Chung-Yung J Lee, Andrew.M Jenner, Barry Halliwell. (2004) Rapid preparation of human urine and plasma samples for analysis of F2-isoprostanes by gas chromatography-mass spectrometry. Biochemical and Biophysical Research Communications 320:3, 696-702
CrossRef209
M. Paola Pellegrini, David E. Newby, Neil R. Johnston, Simon Maxwell, David J. Webb. (2004) Vitamin C Has No Effect on Endothelium-Dependent Vasomotion and Acute Endogenous Fibrinolysis in Healthy Smokers. Journal of Cardiovascular Pharmacology 44:1, 117-124
CrossRef210
TERHI AHOLA, VINETA FELLMAN, INGEMAR KJELLMER, KARI O. RAIVIO, RISTO LAPATTO. (2004) Plasma 8-Isoprostane Is Increased in Preterm Infants Who Develop Bronchopulmonary Dysplasia or Periventricular Leukomalacia. Pediatric Research 56:1, 88-93
CrossRef211
J.-L Cracowski. (2004) Les isoprostanes : un rôle physiopathologique potentiel en pathologie vasculaire. La Revue de Médecine Interne 25:6, 459-463
CrossRef212
Siobhan Mulrennan, Caroline Wright, Rachel Thompson, Peter Goustas, Alyn Morice. (2004) Effect of salbutamol on smoking related cough. Pulmonary Pharmacology & Therapeutics 17:3, 127-131
CrossRef213
Mehdi H. Shishehbor, Stanley L. Hazen. (2004) Inflammatory and oxidative markers in atherosclerosis: Relationship to outcome. Current Atherosclerosis Reports 6:3, 243-250
CrossRef214
L. Flores, M. Vidal, J. Abian, A. Cases, J. Ma. Campistol, J. Clària, S. Lario, E. Esmatjes. (2004) The effects of smoking and its cessation on 8-epi-PGF2α and transforming growth factor-beta 1 in Type 1 diabetes mellitus. Diabetic Medicine 21:3, 285-289
CrossRef215
Jean-Luc Cracowski. (2004) Isoprostanes: an emerging role in vascular physiology and disease?. Chemistry and Physics of Lipids 128:1-2, 75-83
CrossRef216
Kathleen S Montine, Joseph F Quinn, Jing Zhang, Joshua P Fessel, L.Jackson Roberts, Jason D Morrow, Thomas J Montine. (2004) Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chemistry and Physics of Lipids 128:1-2, 117-124
CrossRef217
Domenico Praticò, Joshua Rokach, John Lawson, Garret A. FitzGerald. (2004) F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases. Chemistry and Physics of Lipids 128:1-2, 165-171
CrossRef218
Aı̈da Habib, Kamal F Badr. (2004) Molecular pharmacology of isoprostanes in vascular smooth muscle. Chemistry and Physics of Lipids 128:1-2, 69-73
CrossRef219
Kevin Moore. (2004) Isoprostanes and the liver. Chemistry and Physics of Lipids 128:1-2, 125-133
CrossRef220
WEI-YI ONG, BARRY HALLIWELL. (2004) Iron, Atherosclerosis, and Neurodegeneration: A Key Role for Cholesterol in Promoting Iron-Dependent Oxidative Damage?. Annals of the New York Academy of Sciences 1012:1, 51-64
CrossRef221
Haim Tapiero. (2004) Influence of alcohol consumption and smoking habits on human health. Biomedicine & Pharmacotherapy 58:2, 75-76
CrossRef222
Giovanni Davı̀, Angela Falco, Carlo Patrono. (2004) Determinants of F2-isoprostane biosynthesis and inhibition in man. Chemistry and Physics of Lipids 128:1-2, 149-163
CrossRef223
John W Eikelboom, Graeme J Hankey. (2004) Failure of Aspirin to Prevent Atherothrombosis. American Journal of Cardiovascular Drugs 4:1, 57-67
CrossRef224
Kunihisa Miwa, Satoshi Okinaga, Masatoshi Fujita. (2004) Low Serum α-Tocopherol Concentrations in Subjects With Various Coronary Risk Factors. Circulation Journal 68:6, 542-546
CrossRef225
F. Violi, R. Cangemi, L. Lofredo. 2004. Vitamin E and other antioxidants in the prevention of cardiovascular disease. , 77-98.
CrossRef226
Atsushi HOZAWA, Satoru EBIHARA, Kaori OHMORI, Shinichi KURIYAMA, Takashi UGAJIN, Yayoi KOIZUMI, Yoshinori SUZUKI, Toshifumi MATSUI, Hiroyuki ARAI, Yoshitaka TSUBONO, Hidetada SASAKI, Ichiro TSUJI. (2004) Increased Plasma 8-Isoprostane Levels in Hypertensive Subjects: the Tsurugaya Project. Hypertension Research 27:8, 557-561
CrossRef227
Ali Metin Esen, Irfan Barutcu, Murat Acar, Bumin Degirmenci, Dayimi Kaya, Muhsin Turkmen, Mehmet Melek, Ersel Onrat, Ozlem Batukan Esen, Cevat Kirma. (2004) Effect of Smoking on Endothelial Function and Wall Thickness of Brachial Artery. Circulation Journal 68:12, 1123-1126
CrossRef228
Malcolm Peet, Sandeep Shah, Karupiah Selvam, C N Ramchand. (2004) Polyunsaturated fatty acid levels in red cell membranes of unmedicated schizophrenic patients. World Journal of Biological Psychiatry 5:2, 92-99
CrossRef229
Joseph Quinn, Jeffrey Kaye, Thomas Montine, Robert Stackman. (2004) Phytochemicals in Alzheimer Disease: The Development of Clinical Trials. Pharmaceutical Biology 42:s1, 64-73
CrossRef230
N. Martinelli, D. Girelli, O. Olivieri, C. Stranieri, E. Trabetti, F. Pizzolo, S. Friso, I. Tenuti, S. Cheng, M. A. Grow, P. F. Pignatti, R. Corrocher. (2004) Interaction between smoking and PON2 Ser311Cys polymorphism as a determinant of the risk of myocardial infarction. European Journal of Clinical Investigation 34:1, 14-20
CrossRef231
Akinori Masuda, Masaaki Miyata, Takashi Kihara, Shinichi Minagoe, Chuwa Tei. (2004) Repeated Sauna Therapy Reduces Urinary 8-Epi-Prostaglandin F 2α. Japanese Heart Journal 45:2, 297-303
CrossRef232
T. Hulgan, J. Morrow, R. T. D'Aquila, S. Raffanti, M. Morgan, P. Rebeiro, D. W. Haas. (2003) Oxidant Stress Is Increased during Treatment of Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 37:12, 1711-1717
CrossRef233
Edzard Schwedhelm, Rainer H. Böger. (2003) Application of Gas Chromatography-Mass Spectrometry for Analysis of Isoprostanes: Their Role in Cardiovascular Disease. Clinical Chemistry and Laboratory Medicine 41:12, 1552-1561
CrossRef234
Ravinder D Reddy, Jeffrey K Yao. (2003) Environmental factors and membrane polyunsaturated fatty acids in schizophrenia. Prostaglandins, Leukotrienes and Essential Fatty Acids 69:6, 385-391
CrossRef235
Roswitha M Wolfram, Fahdi Chehne, Anthony Oguogho, Helmut Sinzinger. (2003) Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids. Life Sciences 74:1, 47-53
CrossRef236
Laine J Murphey, Jason D Morrow, Pairunyar Sawathiparnich, Gordon H Williams, Douglas E Vaughan, Nancy J Brown. (2003) Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives. Free Radical Biology and Medicine 35:7, 711-718
CrossRef237
Indra Neil Guha, Kevin Moore. (2003) F2-isoprostanes and the liver. Prostaglandins & Other Lipid Mediators 72:1-2, 73-84
CrossRef238
Kinga A. Powers, Andras Kapus, Rachel G. Khadaroo, Ruijuan He, John C. Marshall, Thomas F. Lindsay, Ori D. Rotstein. (2003) Twenty-five percent albumin prevents lung injury following shock/resuscitation. Critical Care Medicine 31:9, 2355-2363
CrossRef239
Laura D Kauffman, Ronald J Sokol, Richard H Jones, Joseph A Awad, Marian J Rewers, Jill M Norris. (2003) Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus. Free Radical Biology and Medicine 35:6, 551-557
CrossRef240
Grace A. McComsey, Jason D. Morrow. (2003) Lipid Oxidative Markers Are Significantly Increased in Lipoatrophy But Not in Sustained Asymptomatic Hyperlactatemia. JAIDS Journal of Acquired Immune Deficiency Syndromes 34:1, 45-49
CrossRef241
Mark Toraason, Mary Ann Butler, Avima Ruder, Christy Forrester, Lauralynn Taylor, David L Ashley, Patty Mathias, Kate L Marlow, Kenneth L Cheever, Edward Krieg, Howard Wey. (2003) Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 539:1-2, 9-18
CrossRef242
Tiiu Kullisaar, Epp Songisepp, Marika Mikelsaar, Kersti Zilmer, Tiiu Vihalemm, Mihkel Zilmer. (2003) Antioxidative probiotic fermented goats' milk decreases oxidative stress-mediated atherogenicity in human subjects. British Journal of Nutrition 90:02, 449
CrossRef243
Veronique Witko-Sarsat, Valerie Gausson, Anh-Thu Nguyen, Malik Touam, Tilman Drueke, Francesco Santangelo, Beatrice Descamps-Latscha. (2003) AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: A potential target for N-acetylcysteine treatment in dialysis patients. Kidney International 64:1, 82-91
CrossRef244
Vincent Tong, Thomas K.H. Chang, Jie Chen, Frank S. Abbott. (2003) The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats. Free Radical Biology and Medicine 34:11, 1435-1446
CrossRef245
Cristina Vassalle, Nicoletta Botto, Maria Andreassi, Sergio Berti, Andrea Biagini. (2003) Coronary Artery Disease 14:3, 213-218
CrossRef246
Toshiaki Ishizuka, Takemi Matsui, Akira Kurita. (2003) Ramatroban, a TP receptor antagonist, improves vascular responses to acetylcholine in hypercholesterolemic rabbits in vivo. European Journal of Pharmacology 468:1, 27-35
CrossRef247
Cristina Vassalle, Nicoletta Botto, Maria Grazia Andreassi, Sergio Berti, Andrea Biagini. (2003) Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease. Coronary Artery Disease 14:3, 213-218
CrossRef248
Joakim Huber, Valery N. Bochkov, Bernd R. Binder, Norbert Leitinger. (2003) The Isoprostane 8-iso-PGE 2 Stimulates Endothelial Cells to Bind Monocytes via Cyclic AMP- and p38 MAP Kinase-Dependent Signaling Pathways. Antioxidants & Redox Signaling 5:2, 163-169
CrossRef249
A.T Ulus, A Aksoyek, M Ozkan, S.F Katircioglu, S Basu. (2003) Cardiopulmonary bypass as a cause of free radical-induced oxidative stress and enhanced blood-borne isoprostanes in humans. Free Radical Biology and Medicine 34:7, 911-917
CrossRef250
Kunihisa Miwa, Chiharu Kishimoto, Hajime Nakamura, Toshinori Makita, Katsuhisa Ishii, Nobuaki Okuda, Ataru Taniguchi, Keisuke Shioji, Junji Yodoi, Shigetake Sasayama. (2003) Increased oxidative stress with elevated serum thioredoxin level in patients with coronary spastic angina. Clinical Cardiology 26:4, 177-181
CrossRef251
Katsuyuki Ando, Toshiro Fujita. (2003) Lessons from the adrenomedullin knockout mouse. Regulatory Peptides 112:1-3, 185-188
CrossRef252
Joseph R Hibbeln, Kevin K Makino, Catherine E Martin, Faith Dickerson, John Boronow, Wayne S Fenton. (2003) Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. Biological Psychiatry 53:5, 431-441
CrossRef253
Emma I Waddington, Kevin D Croft, Kishore Sienuarine, Bruce Latham, Ian B Puddey. (2003) Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. Atherosclerosis 167:1, 111-120
CrossRef254
Yuanling Liang, Ping Wei, Russell W Duke, Peter D Reaven, S.Mitchell Harman, Richard G Cutler, Christopher B Heward. (2003) Quantification of 8-iso-prostaglandin-F2α and 2,3-dinor-8-iso-prostaglandin-F2α in human urine using liquid chromatography-tandem mass spectrometry. Free Radical Biology and Medicine 34:4, 409-418
CrossRef255
Joanne Terentis a, Roland "Stocker a,b", Leonard "Kritharides b,c", Andrew Upston a. 2003. Is There a Role for Vitamin E in the Prevention of Atherosclerosis?. .
CrossRef256
Gen Yoshino, Tsutomu Hirano, Tsutomu Kazumi, Masayo Takemoto, Noriko Ohashi. (2003) Fluvastatin Increases LDL Particle Size and Reduces Oxidative Stress in Patients with Hyperlipidemia. Journal of Atherosclerosis and Thrombosis 10:6, 343-347
CrossRef257
Teruo Inoue, Masatoshi Hayashi, Kan Takayanagi, Shigenori Morooka. (2003) Oxidative DNA Damage is Induced by Chronic Cigarette Smoking, but Repaired by Abstention. JOURNAL OF HEALTH SCIENCE 49:3, 217-220
CrossRef258
Tsung-Ming Lee, Tsai-Fwu Chou, Chang-Her Tsai. (2002) Association of Pravastatin and Left Ventricular Mass in Hypercholesterolemic Patients: Role of 8-Iso-Prostaglandin F2α Formation. Journal of Cardiovascular Pharmacology 40:6, 868-874
CrossRef259
F. Chehne, A. Oguogho, G. Lupattelli, B. Palumbo, H. Sinzinger. (2002) Effect of giving up cigarette smoking and restarting in patients with clinically manifested atherosclerosis. Prostaglandins, Leukotrienes and Essential Fatty Acids 67:5, 333-339
CrossRef260
T.P Stein. (2002) Space flight and oxidative stress. Nutrition 18:10, 867-871
CrossRef261
Leonard Kritharides, Roland Stocker. (2002) The use of antioxidant supplements in coronary heart disease. Atherosclerosis 164:2, 211-219
CrossRef262
N. KIRSCHVINK, N. SMITH, L. FIÉVEZ, V. BOUGNET, T. ART, G. DEGAND, D. MARLIN, C. ROBERTS, B. GÉNICOT, P. LINDSEY, P. LEKEUX. (2002) Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses. Equine Veterinary Journal 34:6, 563-571
CrossRef263
Marta Kankofer. (2002) 8-iso-prostaglandin F2α as a marker of tissue oxidative damage in bovine retained placenta. Prostaglandins & Other Lipid Mediators 70:1-2, 51-59
CrossRef264
Thomas J Montine, M.Diana Neely, Joseph F Quinn, M.Flint Beal, William R Markesbery, L.Jackson Roberts, Jason D Morrow. (2002) Lipid peroxidation in aging brain and Alzheimer’s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.. Free Radical Biology and Medicine 33:5, 620-626
CrossRef265
A. D. Blann, C. N. McCollum, G. Y. H. Lip. (2002) Relationship between plasma markers of endothelial cell integrity and the Framingham cardiovascular disease risk-factor scores in apparently healthy individuals. Blood Coagulation & Fibrinolysis 13:6, 513-518
CrossRef266
Helmut Schröder, Jaume Marrugat, Roberto Elosua, Maribel I. Covas. (2002) Tobacco and alcohol consumption: impact on other cardiovascular and cancer risk factors in a southern European Mediterranean population. British Journal of Nutrition 88:03, 273
CrossRef267
Nicoletta Botto, Serena Masetti, Lucia Petrozzi, Cristina Vassalle, Samantha Manfredi, Andrea Biagini, Maria Grazia Andreassi. (2002) Elevated levels of oxidative DNA damage in patients with coronary artery disease. Coronary Artery Disease 13:5, 269-274
CrossRef268
Umberto Campia, Wassim K Choucair, Melissa B Bryant, Myron A Waclawiw, Carmine Cardillo, Julio A Panza. (2002) Reduced endothelium-dependent and -independent dilation of conductance arteries in African Americans. Journal of the American College of Cardiology 40:4, 754-760
CrossRef269
Thomas J. Montine, Joseph F. Quinn, Dejan Milatovic, Lisa C. Silbert, Theresa Dang, Stephanie Sanchez, Erin Terry, L. Jackson Roberts, Jeffrey A. Kaye, Jason D. Morrow. (2002) Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Annals of Neurology 52:2, 175-179
CrossRef270
Helmut Sinzinger, Roswitha Wolfram, Bernhard A. Peskar. (2002) Muscular Side Effects of Statins. Journal of Cardiovascular Pharmacology 40:2, 163-171
CrossRef271
Jean-Luc Cracowski, Thierry Durand, Germain Bessard. (2002) Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications. Trends in Pharmacological Sciences 23:8, 360-366
CrossRef272
Cristina Vassalle, Valter Lubrano, Antonio L'Abbate, Aldo Clerico. (2002) Determination of Nitrite Plus Nitrate and Malondialdehyde in Human Plasma: Analytical Performance and the Effect of Smoking and Exercise. Clinical Chemistry and Laboratory Medicine 40:8, 802-809
CrossRef273
E. Esmatjes, F. De Alvaro. (2002) Incidence of diabetic nephropathy in Type 1 diabetic patients in Spain: ‘Estudio Diamante’. Diabetes Research and Clinical Practice 57:1, 35-43
CrossRef274
Toru Suzuki, Hiroaki Kohno, Akira Hasegawa, Shunichi Toshima, Toshihiro Amaki, Masahiko Kurabayashi, Ryozo Nagai. (2002) Diagnostic implications of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary artery disease. Clinical Biochemistry 35:5, 347-353
CrossRef275
Eileen M. Bulger, Iris Garcia, Ronald V. Maier. (2002) Intracellular Antioxidant Activity is Necessary to Modulate the Macrophage Response to Endotoxin. Shock 18:1, 58-63
CrossRef276
Jean-Luc Cracowski, Patrick H. Carpentier, Bernard Imbert, Sandrine Cachot, Fran
oise Stanke-Labesque, Janine Bessard, Germain Bessard. (2002) Increased urinary F2-isoprostanes in systemic sclerosis, but not in primary Raynaud's phenomenon: Effect of cold exposure. Arthritis & Rheumatism 46:5, 1319-1323
CrossRef277
Peter Steer, Jonas Millgård, Dennis M. Sarabi, Samar Basu, Bengt Vessby, Thomas Kahan, Magnus Edner, Lars Lind. (2002) Cardiac and vascular structure and function are related to lipid peroxidation and metabolism. Lipids 37:3, 231-236
CrossRef278
E. J. Duell. (2002) A Population-Based, Case-Control Study of Polymorphisms in Carcinogen-Metabolizing Genes, Smoking, and Pancreatic Adenocarcinoma Risk. CancerSpectrum Knowledge Environment 94:4, 297-306
CrossRef279
Francesco Violi, Luigi Iuliano, Garret A FitzGerald. (2002) Reply. Journal of the American College of Cardiology 39:3, 554-555
CrossRef280
Jean-Luc Cracowski, Stephanie Marliere, Germain Bessard. (2002) Vasomotor effects and pathophysiologic relevance of F2-isoprostane formation in vascular diseases. Journal of the American College of Cardiology 39:3, 554
CrossRef281
Kaori SHINOMIYA, Megumu FUKUNAGA, Hideyasu KIYOMOTO, Katsufumi MIZUSHIGE, Teppei TSUJI, Takahisa NOMA, Koji OHMORI, Masakazu KOHNO, Shoichi SENDA. (2002) A Role of Oxidative Stress-Generated Eicosanoid in the Progression of Arteriosclerosis in Type 2 Diabetes Mellitus Model Rats. Hypertension Research 25:1, 91-98
CrossRef282
Samantha Manfredi, Serena Masetti, Nicoletta Botto, Maria Giovanna Colombo, Marco Terrazzi, Cristina Vassalle, Andrea Biagini, Maria Grazia Andreassi. (2002) p53 codon 72 polymorphism in coronary artery disease: No evidence for association with increased risk or micronucleus frequency. Environmental and Molecular Mutagenesis 40:2, 110-115
CrossRef283
Yoshinori Takajo, Hisao Ikeda, Nobuya Haramaki, Toyoaki Murohara, Tsutomu Imaizumi. (2001) Augmented oxidative stress of platelets in chronic smokers. Journal of the American College of Cardiology 38:5, 1320-1327
CrossRef284
Balz Frei, Anitra Carr. 2001. Vitamin C and Cardiovascular Diseases. .
CrossRef285
Thomas Montine, Erin Reich, Stephanie Sanchez, William Zackert, L Jackson Roberts, Jason Morrow, Brian Cox, Daniel Van der Ende, Erin Terry. 2001. Quantification of Isoprostanes as Indicators of Oxidant Stress in Vivo. .
CrossRef286
Angela Mastaloudis, Scott W Leonard, Maret G Traber. (2001) Oxidative stress in athletes during extreme endurance exercise. Free Radical Biology and Medicine 31:7, 911-922
CrossRef287
Samar Basu, Karl Michaëlsson, Helena Olofsson, Sara Johansson, Håkan Melhus. (2001) Association between Oxidative Stress and Bone Mineral Density. Biochemical and Biophysical Research Communications 288:1, 275-279
CrossRef288
Ursula Jurt, Tommaso Gori, Amir Ravandi, Saeid Babaei, Peter Zeman, John D. Parker. (2001) Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study. Journal of the American College of Cardiology 38:3, 854-859
CrossRef289
J. Helmersson, S. Basu. (2001) F2-isoprostane and prostaglandin F2αmetabolite excretion rate and day to day variation in healthy humans. Prostaglandins, Leukotrienes and Essential Fatty Acids 65:2, 99-102
CrossRef290
A. Budinsky, R. Wolfram, A. Oguogho, Y. Efthimiou, Y. Stamatopoulos, H. Sinzinger. (2001) Regular ingestion of opuntia robusta lowers oxidation injury. Prostaglandins, Leukotrienes and Essential Fatty Acids 65:1, 45-50
CrossRef291
F. Chehne, A. Oguogho, G. Lupattelli, A.C. Budinsky, B. Palumbo, H. Sinzinger. (2001) Increase of isoprostane 8-epi-PGF2 αafter restarting smoking. Prostaglandins, Leukotrienes and Essential Fatty Acids 64:6, 307-310
CrossRef292
Yu Yamaguchi, Sachiko Matsuno, Satomi Kagota, Jun Haginaka, Masaru Kunitomo. (2001) Oxidants in cigarette smoke extract modify low-density lipoprotein in the plasma and facilitate atherogenesis in the aorta of Watanabe heritable hyperlipidemic rabbits. Atherosclerosis 156:1, 109-117
CrossRef293
P. R
CrossRef294
Lambertus J.H van Tits, Frouwkje de Waart, Heidi L.M Hak-Lemmers, Pieternel van Heijst, Jacqueline de Graaf, Pierre N.M Demacker, Anton F.H Stalenhoef. (2001) Effects of α-tocopherol on superoxide production and plasma intercellular adhesion molecule-1 and antibodies to oxidized LDL in chronic smokers. Free Radical Biology and Medicine 30:10, 1122-1129
CrossRef295
Garry J. Handelman, Mary F. Walter, Rohini Adhikarla, Jonathan Gross, Gerard E. Dallal, Nathan W. Levin, Jeffrey B. Blumberg. (2001) Elevated plasma F2-isoprostanes in patients on long-term hemodialysis. Kidney International 59:5, 1960-1966
CrossRef296
Leopoldo Raij, Eugene G. DeMaster, Edgar A. Jaimes. (2001) Cigarette smoke-induced endothelium dysfunction: role of superoxide anion. Journal of Hypertension 19:5, 891-897
CrossRef297
Sahebarao P. Mahadik, Denise Evans, Harbns Lal. (2001) Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 25:3, 463-493
CrossRef298
Julius H Cranshaw, Timothy W Evans, Jane A Mitchell. (2001) Characterization of the effects of isoprostanes on platelet aggregation in human whole blood. British Journal of Pharmacology 132:8, 1699-1706
CrossRef299
Rima Abu-Amsha Caccetta, Valerie Burke, Trevor A Mori, Lawrence J Beilin, Ian B Puddey, Kevin D Croft. (2001) Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects. Free Radical Biology and Medicine 30:6, 636-642
CrossRef300
A. Oguogho, H. Kritz, O. Wagner, H. Sinzinger. (2001) 6-oxo-PGF1 αand 8-epi-PGF2 αin the arterial wall layers of various species: a comparison between intact and atherosclerotic areas. Prostaglandins, Leukotrienes and Essential Fatty Acids 64:3, 167-171
CrossRef301
R van den Berg. (2001) Nuclear factor-κB activation is higher in peripheral blood mononuclear cells of male smokers. Environmental Toxicology and Pharmacology 9:4, 147-151
CrossRef302
Christian Stier, Horst Schweer, Jürgen Jelinek, Bernhard Watzer, Hannsjörg W. Seyberth, Andreas Leonhardt. (2001) Effect of Preterm Formula With and Without Long-Chain Polyunsaturated Fatty Acids on the Urinary Excretion of F2-Isoprostanes and 8-Epi-Prostaglandin F2α. Journal of Pediatric Gastroenterology and Nutrition 32:2, 137-141
CrossRef303
William MacNee, Irfan Rahman. (2001) Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?. Trends in Molecular Medicine 7:2, 55-62
CrossRef304
Yutaka Wako, Michiko Satoh, Kenichi Suzuki. (2001) 8-Hydroxydeoxyguanosine Levels in White Blood Cell DNA and ex vivo Oxidation Resistance of Plasma in Smokers.. The Tohoku Journal of Experimental Medicine 194:2, 99-106
CrossRef305
Stephan R. Orth, Christiane Viedt, Eberhard Ritz. (2001) Adverse Effects of Smoking in the Renal Patient.. The Tohoku Journal of Experimental Medicine 194:1, 1-15
CrossRef306
L J Janssen, M Premji, S Netherton, J Coruzzi, H Lu-Chao, P G Cox. (2001) Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. British Journal of Pharmacology 132:1, 127-134
CrossRef307
Neil P Andrews, Abhiram Prasad, Arshed A Quyyumi. (2001) N-acetylcysteine improves coronary and peripheral vascular function. Journal of the American College of Cardiology 37:1, 117-123
CrossRef308
T. J. Montine, L. Shinobu, K. S. Montine, L. J. Roberts, N. W. Kowall, M. F. Beal, J. D. Morrow. (2000) No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls. Annals of Neurology 48:6, 950-950
CrossRef309
F. W. P. J. van den Berkmortel, P. N. M. Demacker, H. Wollersheim, T. Thien, A. F. H. Stalenhoef. (2000) Smoking or its cessation does not alter the susceptibility to in vitro LDL oxidation. European Journal of Clinical Investigation 30:11, 972-979
CrossRef310
Jean-Michel Halimi, Albert Mimran. (2000) Systemic and renal effect of nicotine in non-smokers. Journal of Hypertension 18:11, 1665-1669
CrossRef311
Angel Montero, Karen A. Munger, Rizwan Z. Khan, Jose M. Valdivielso, Jason D. Morrow, Antonio Guasch, Fuad N. Ziyadeh, Kamal F. Badr. (2000) F2-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes. Kidney International 58:5, 1963-1972
CrossRef312
E. Södergren, B. Vessby, S. Basu. (2000) Radioimmunological measurement of F2-isoprostanes after hydrolysis of lipids in tissues. Prostaglandins, Leukotrienes and Essential Fatty Acids 63:3, 149-152
CrossRef313
Lisa G. Wood, Dominic A. Fitzgerald, Peter C. Gibson, David M. Cooper, Manohar L. Garg. (2000) Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma. Lipids 35:9, 967-974
CrossRef314
Robert T. Eberhardt, Marc A. Forgione, Andre Cap, Jane A. Leopold, M. Audrey Rudd, Maria Trolliet, Stanley Heydrick, Rachel Stark, Elizabeth S. Klings, Nicanor I. Moldovan, Mohammed Yaghoubi, Pascal J. Goldschmidt-Clermont, Harrison W. Farber, Richard Cohen, Joseph Loscalzo. (2000) Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. Journal of Clinical Investigation 106:4, 483-491
CrossRef315
LJ Janssen. (2000) Isoprostanes: Generation, Pharmacology, and Roles in Free-radical-mediated Effects in the Lung. Pulmonary Pharmacology & Therapeutics 13:4, 149-155
CrossRef316
Yun Qin, Chi Chiu Wang, Hartmut Kuhn, Jorg Rathmann, Chi Pui Pang, Michael Scott Rogers. (2000) Determinants of umbilical cord arterial 8-iso-prostaglandin F2alpha concentrations. BJOG: An International Journal of Obstetrics and Gynaecology 107:8, 973-981
CrossRef317
F.G. de Waart, T.J. Smilde, H. Wollersheim, A.F.H. Stalenhoef, F.J. Kok. (2000) Smoking characteristics, antioxidant vitamins, and carotid artery wall thickness among life-long smokers. Journal of Clinical Epidemiology 53:7, 707-714
CrossRef318
Yuriko Murai, Takanori Hishinuma, Naoto Suzuki, Jo Satoh, Takayoshi Toyota, Michinao Mizugaki. (2000) Determination of urinary 8-epi-prostaglandin F2α using liquid chromatography-tandem mass spectrometry: increased excretion in diabetics. Prostaglandins & Other Lipid Mediators 62:2, 173-181
CrossRef319
Richard C O'Brien, Ming Luo, Nicholas Balazs, Joanne Mercuri. (2000) In vitro and in vivo antioxidant properties of gliclazide. Journal of Diabetes and its Complications 14:4, 201-206
CrossRef320
Heidemarie Pilz, Anthony Oguogho, Fahdi Chehne, Graziana Lupattelli, Barbara Palumbo, Helmut Sinzinger. (2000) Quitting Cigarette Smoking Results in a Fast Improvement of in vivo Oxidation Injury (Determined via Plasma, Serum and Urinary Isoprostane). Thrombosis Research 99:3, 209-221
CrossRef321
Stephen M. Prescott, Guy A. Zimmerman, Diana M. Stafforini, Thomas M. McIntyre. (2000) P
LATELET -ACTIVATING FACTOR AND RELATED LIPID MEDIATORS . Annual Review of Biochemistry 69:1, 419-445
CrossRef322
Bénédicte Gardan, Jean-Luc Cracowski, Carmine Sessa, Mark Hunt, Françoise Stanke-Labesque, Philippe Devillier, Germain Bessard. (2000) Vasoconstrictor Effects of Iso-Prostaglandin F2α Type-III (8-Iso-Prostaglandin F2α) on Human Saphenous Veins. Journal of Cardiovascular Pharmacology 35:5, 729-734
CrossRef323
Jean-Luc Cracowski, Françoise Stanke-Labesque, Philippe Devillier, Olivier Chavanon, Mark Hunt, Claude Souvignet, Germain Bessard. (2000) Human internal mammary artery contraction by isoprostaglandin F2α type-III (8-iso-prostaglandin F2α). European Journal of Pharmacology 397:1, 161-168
CrossRef324
Olli T Raitakari, Mark R Adams, Robyn J McCredie, Kaye A Griffiths, Roland Stocker, David S Celermajer. (2000) Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect. Journal of the American College of Cardiology 35:6, 1616-1621
CrossRef325
A. Oguogho, A. Ferlitsch, H. Sinzinger. (2000) LDL-apheresis decreases plasma levels and urinary excretion of 8-epi-PGF2α. Prostaglandins, Leukotrienes and Essential Fatty Acids 62:4, 209-216
CrossRef326
Jigme M. Sethi, Carolyn L. Rochester. (2000) SMOKING AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Clinics in Chest Medicine 21:1, 67-86
CrossRef327
Maret G. Traber, Albert van der Vliet, Abraham Z. Reznick, Carroll E. Cross. (2000) TOBACCO-RELATED DISEASES. Clinics in Chest Medicine 21:1, 173-187
CrossRef328
Mahziar Sarabi, Lars Lind. (2000) Short-Term Effects of Smoking and Nicotine Chewing Gum on Endothelium-Dependent Vasodilation in Young Healthy Habitual Smokers. Journal of Cardiovascular Pharmacology 35:3, 451-456
CrossRef329
S Basu. (2000) Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Letters 468:1, 33-36
CrossRef330
Thomas Neunteufl, Ute Priglinger, Sandra Heher, Manfred Zehetgruber, Gabor Söregi, Stephan Lehr, Kurt Huber, Gerald Maurer, Franz Weidinger, Karam Kostner. (2000) Effects of vitamin E on chronic and acute endothelial dysfunction in smokers. Journal of the American College of Cardiology 35:2, 277-283
CrossRef331
L Oliveira, N A Stallwood, D J Crankshaw. (2000) Effects of some isoprostanes on the human umbilical artery in vitro. British Journal of Pharmacology 129:3, 509-514
CrossRef332
Miia M Valkonen, Timo Kuusi. (2000) Vitamin C prevents the acute atherogenic effects of passive smoking. Free Radical Biology and Medicine 28:3, 428-436
CrossRef333
L.Jackson Roberts, Jason D Morrow. (2000) Measurement of F2-isoprostanes as an index of oxidative stress in vivo. Free Radical Biology and Medicine 28:4, 505-513
CrossRef334
Elizabeth J. Johnson. (2000) The Role of Lycopene in Health and Disease. Nutrition in Clinical Care 3:1, 35-43
CrossRef335
Makoto Ayaori, Tetsuya Hisada, Michio Suzukawa, Hiroshi Yoshida, Masato Nishiwaki, Toshimitsu Ito, Kei Nakajima, Kenji Higashi, Atsushi Yonemura, Toshitsugu Ishikawa, Fumitaka Ohsuzu, Haruo Nakamura. (2000) Plasma Levels and Redox Status of Ascorbic Acid and Levels of Lipid Peroxidation Products in Active and Passive Smokers. Environmental Health Perspectives 108:2, 105-108
CrossRef336
Claude Souvignet, Jean-Luc Cracowski, Françoise Stanke-Labesque, Germain Bessard. (2000) Are isoprostanes a clinical marker for antioxidant drug investigation?. Fundamental & Clinical Pharmacology 14:1, 1-10
CrossRef337
A. Oguogho, J. Kaliman, H. Sinzinger. (2000) Eicosanoid generation and responsiveness of human lymphatics in hyperlipoproteinemia. Prostaglandins, Leukotrienes and Essential Fatty Acids 62:1, 47-52
CrossRef338
Trevor T Hansel, Maggie J Leckie, Shannon A Bryan, Peter J Barnes. (2000) Novel therapy for COPD. Expert Opinion on Investigational Drugs 9:1, 3-23
CrossRef339
Michael G. Goldstein, Raymond Niaura. (2000) METHODS TO ENHANCE SMOKING CESSATION AFTER MYOCARDIAL INFARCTION. Medical Clinics of North America 84:1, 63-80
CrossRef340
Òscar Miró, Josep Ramon Alonso, Jordi Casademont, Diana Jarreta, Álvaro Urbano-Márquez, Francesc Cardellach. (1999) Oxidative damage on lymphocyte membranes is increased in patients suffering from acute carbon monoxide poisoning. Toxicology Letters 110:3, 219-223
CrossRef341
Domenico Praticò. (1999) F2-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo. Atherosclerosis 147:1, 1-10
CrossRef342
Garry G. Duthie. (1999) Determination of activity of antioxidants in human subjects. Proceedings of the Nutrition Society 58:04, 1015-1024
CrossRef343
PATRICIA EVANS, BARRY HALLIWELL. (1999) Free Radicals and Hearing: Cause, Consequence, and Criteria. Annals of the New York Academy of Sciences 884:1 OTOTOXICITY, 19-40
CrossRef344
Joseph P. Frolkis. (1999) SCREENING FOR CARDIOVASCULAR DISEASE. Medical Clinics of North America 83:6, 1339-1373
CrossRef345
Daniel Hwang, Prithiva Chanmugam, Mary Boudreau, Kyung H Sohn, Koni Stone, William A Pryor. (1999) Activation and inactivation of cyclo-oxygenase in rat alveolar macrophages by aqueous cigarette tar extracts. Free Radical Biology and Medicine 27:5-6, 673-682
CrossRef346
H. Helmersson, S. Basu. (1999) F2-Isoprostane excretion rate and diurnal variation in human urine. Prostaglandins, Leukotrienes and Essential Fatty Acids 61:3, 203-205
CrossRef347
Christopher J Fowler, Elsa Sjöberg, Gunnar Tiger. (1999) Serotonin stimulation of calcium mobilisation in human platelets: choice of units of measurement, effects of age and tobacco use, and correlation with serotonin2A receptor density. Clinica Chimica Acta 287:1-2, 1-18
CrossRef348
Takafumi Yura, Megumu Fukunaga, Rizwan Khan, George N. Nassar, Kamal F. Badr, Angel Montero. (1999) Free-radical-generated F2-isoprostane stimulates cell proliferation and endothelin-1 expression on endothelial cells. Kidney International 56:2, 471-478
CrossRef349
Abhiram Prasad, Neil P Andrews, Feroz A Padder, Mohsin Husain, Arshed A Quyyumi. (1999) Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability. Journal of the American College of Cardiology 34:2, 507-514
CrossRef350
S. S. Hecht. (1999) Tobacco Smoke Carcinogens and Lung Cancer. JNCI Journal of the National Cancer Institute 91:14, 1194-1210
CrossRef351
Tsan Liu, Arnold Stern, L. Jackson Roberts, Jason D. Morrow. (1999) The isoprostanes: Novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid. Journal of Biomedical Science 6:4, 226-235
CrossRef352
S Zahler, B.F Becker. (1999) Indirect enhancement of neutrophil activity and adhesion to cultured human umbilical vein endothelial cells by isoprostanes (iPF2α-III and iPE2-III). Prostaglandins & Other Lipid Mediators 57:5-6, 319-331
CrossRef353
Reinhard Obwegeser, Anthony Oguogho, Martin Ulm, Peter Berghammer, Helmut Sinzinger. (1999) Maternal cigarette smoking increases F2-isoprostanes and reduces prostacyclin and nitric oxide in umbilical vessels. Prostaglandins & Other Lipid Mediators 57:4, 269-279
CrossRef354
Jayne V Woodside, Ian S Young, John W.G Yarnell, Heather E Roxborough, Dorothy McMaster, Evelyn E McCrum, K.Fred Gey, Alun Evans. (1999) Antioxidants, but not B-group vitamins increase the resistance of low-density lipoprotein to oxidation: a randomized, factorial design, placebo-controlled trial. Atherosclerosis 144:2, 419-427
CrossRef355
Paul M. Walker, Alexander D. Romaschin, Scott Davis, John Piovesan. (1999) Lower Limb Ischemia: Phase 1 Results of Salvage Perfusion. Journal of Surgical Research 84:2, 193-198
CrossRef356
J Kuyvenhoven. (1999) Oxidative stress and diabetes mellitus Pathogenesis of long-term complications. European Journal of Internal Medicine 10:1, 9-19
CrossRef357
Stephen D. Milone, Cecil R. Pace-Asciak, Denis Reynaud, Eduardo R. Azevedo, Gary E. Newton, John D. Parker. (1999) Biochemical, Hemodynamic, and Vascular Evidence Concerning the Free Radical Hypothesis of Nitrate Tolerance. Journal of Cardiovascular Pharmacology 33:5, 685-690
CrossRef358
Barry Halliwell. (1999) Establishing the Significance and Optimal Intake of Dietary Antioxidants: The Biomarker Concept. Nutrition Reviews 57:4, 104-113
CrossRef359
Kimberly S. Fuson, Robert J. Mark, Jill A. Panetta, Patrick C. May. (1999) Characterization of LY231617 Protection Against Hydrogen Peroxide Toxicity. Journal of Neurochemistry 72:3, 1154-1160
CrossRef360
Daniell B Hill, Joseph A Awad. (1999) Increased urinary F2-isoprostane excretion in alcoholic liver disease. Free Radical Biology and Medicine 26:5-6, 656-660
CrossRef361
Rob J. van Klaveren, Benoit Nemery. (1999) Role of reactive oxygen species in occupational and environmental obstructive pulmonary diseases. Current Opinion in Pulmonary Medicine 5:2, 118
CrossRef362
Robert J. Mark, Kimberly S. Fuson, Patrick C. May. (1999) Characterization of 8-Epiprostaglandin F2α as aMarker of Amyloid β-Peptide-Induced Oxidative Damage. Journal of Neurochemistry 72:3, 1146-1153
CrossRef363
Thomas Heitzer, Seppo Ylä Herttuala, Elke Wild, Jukka Luoma, Helmut Drexler. (1999) Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both. Journal of the American College of Cardiology 33:2, 499-505
CrossRef364
Stephen D Milone, Gary E Newton, John D Parker. (1999) Hemodynamic and biochemical effects of 100% oxygen breathing in humans. Canadian Journal of Physiology and Pharmacology 77:2, 124-130
CrossRef365
S. Basu. 1999. Radioimmunoassays of Isoprostanes and Prostaglandins as Biomarkers of Oxidative Stress and Inflammation. , 260-267.
CrossRef366
Loeckie L de Zwart, John H.N Meerman, Jan N.M Commandeur, Nico P.E Vermeulen. (1999) Biomarkers of free radical damage. Free Radical Biology and Medicine 26:1-2, 202-226
CrossRef367
Martin J. Mueller. (1998) Radically novel prostaglandins in animals and plants: the isoprostanes. Chemistry & Biology 5:12, R323-R333
CrossRef368
Tsan-Zon Liu, Arnold Stern, Jason D. Morrow. (1998) The isoprostanes: Unique bioactive products of lipid peroxidation. Journal of Biomedical Science 5:6, 415-420
CrossRef369
Victor L. Schuster. (1998) MOLECULAR MECHANISMS OF PROSTAGLANDIN TRANSPORT. Annual Review of Physiology 60:1, 221-242
CrossRef370
Patrice M Becker, Scherer P Sanders, Patricia Price, Brian W Christman. (1998) F2-isoprostane generation in isolated ferret lungs after oxidant injury or ventilated ischemia. Free Radical Biology and Medicine 25:6, 703-711
CrossRef371
Rainer H. Böger, Stefanie M. Bode-Böger, Laddaval Phivthong-ngam, Ralf P. Brandes, Edzard Schwedhelm, Andreas Mügge, Michael Böhme, Dimitrios Tsikas, Jürgen C. Frölich. (1998) Dietary l-arginine and α-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms. Atherosclerosis 141:1, 31-43
CrossRef372
A.M. Turpeinen, S. Basu, M. Mutanen. (1998) A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids 59:3, 229-233
CrossRef373
B. M. Kromer, J. R. Tippins. (1998) Actions of 8-Epi Prostaglandin F2α on Isolated Rat Aorta. Journal of Cardiovascular Pharmacology 32:3, 471-478
CrossRef374
A. T. Diplock, J.-L. Charuleux, G. Crozier-Willi, F. J. Kok, C. Rice-Evans, M. Roberfroid, W. Stahl, J. Viña-Ribes. (1998) Functional food science and defence against reactive oxidative species. British Journal of Nutrition 80:S1, S77
CrossRef375
Mark R Adams, Jacqui Robinson, Robyn McCredie, J.Paul Seale, Keld E Sorensen, John E Deanfield, David S Celermajer. (1998) Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. Journal of the American College of Cardiology 32:1, 123-127
CrossRef376
Yoram Solberg, Mordechai Rosner, Michael Belkin. (1998) The Association Between Cigarette Smoking and Ocular Diseases. Survey of Ophthalmology 42:6, 535-547
CrossRef377
Sahebarao P Mahadik, Sukdeb Mukherjee, Russell Scheffer, Elizabeth E Correnti, Jayasri S Mahadik. (1998) Elevated Plasma Lipid Peroxides at the Onset of Nonaffective Psychosis. Biological Psychiatry 43:9, 674-679
CrossRef378
Gilbert S. Omenn. (1998) CHEMOPREVENTION OF LUNG CANCER: The Rise and Demise of Beta-Carotene. Annual Review of Public Health 19:1, 73-99
CrossRef379
S. Basu. (1998) Radioimmunosassay of 8-iso-prostaglandin F2α: an index for oxidative injury via free radical catalysed lipid peroxidation. Prostaglandins, Leukotrienes and Essential Fatty Acids 58:4, 319-325
CrossRef380
Martina Britten, Volker Schächinger. (1998) Bedeutung der Endothelfunktion für ischämische Manifestationen der koronaren Atherosklerose. Herz 23:2, 97-105
CrossRef381
Malcolm Peet, Brendan Murphy, Janet Shay, David Horrobin. (1998) Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients. Biological Psychiatry 43:5, 315-319
CrossRef382
Semyon I. Aleynik, Maria Anna Leo, Maria K. Aleynik, Charles S. Lieber. (1998) Increased Circulating Products of Lipid Peroxidation in Patients with Alcoholic Liver Disease. Alcoholism: Clinical and Experimental Research 22:1, 192-196
CrossRef383
Steven K. Clinton. (1998) Lycopene: Chemistry, Biology, and Implications for Human Health and Disease. Nutrition Reviews 56:2, 35-51
CrossRef384
Li Ma, Jimmy Y. C. Chow, Chi H. Cho. (1998) Effects of Cigarette Smoking on Gastric Ulcer Formation and Healing: Possible Mechanisms of Action. Journal of Clinical Gastroenterology 27, S80-S86
CrossRef385
K. Fred Gey. (1998) Vitamins E plus C and interacting conutrients required for optimal health. BioFactors 7:1-2, 113-174
CrossRef386
C.M. Hart, R.J. Karman, T.L. Blackburn, M.P. Gupta, J.G.N. Garcia, E.R. Mohler. (1998) Role of 8-epi PGF2α, 8-isoprostane, in H2O2-induced derangements of pulmonary artery endothelial cell barrier function. Prostaglandins, Leukotrienes and Essential Fatty Acids 58:1, 9-16
CrossRef387
(1997) Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty. New England Journal of Medicine 337:26, 1918-1919
Full Text388
STEPHEN S. HECHT. (1997) Tobacco and Cancer: Approaches Using Carcinogen Biomarkers and Chemoprevention. Annals of the New York Academy of Sciences 833:1 Cancer, 91-111
CrossRef389
Claudio Galli, Franca Marangoni. (1997) Recent advances in the biology of n-6 fatty acids. Nutrition 13:11-12, 978-985
CrossRef390
L.P.L. van de Vijver, A.F.M. Kardinaal, D.E. Grobbee, H.M.G. Princen, G. van Poppel. (1997) Lipoprotein oxidation, antioxidants and cardiovascular risk: epidemiologic evidence. Prostaglandins, Leukotrienes and Essential Fatty Acids 57:4-5, 479-487
CrossRef391
Nalini Santanam, Robert Sanchez, Sheldon Hendler, Sampath Parthasarathy. (1997) Aqueous extracts of cigarette smoke promote the oxidation of low density lipoprotein by peroxidases. FEBS Letters 414:3, 549-551
CrossRef392
Angela Bachi, Raffaella Brambilla, Roberto Fanelli, Roberto Bianchi, Ettore Zuccato, Chiara Chiabrando. (1997) Reduction of urinary 8-epi-prostaglandin F 2 α during cyclo-oxygenase inhibition in rats but not in man. British Journal of Pharmacology 121:8, 1770-1774
CrossRef393
Neal L Benowitz, Steven G Gourlay. (1997) Cardiovascular Toxicity of Nicotine: Implications for Nicotine Replacement Therapy. Journal of the American College of Cardiology 29:7, 1422-1431
CrossRef394
Karen B. Jourdan, Jane A. Mitchell, Timothy W. Evans. (1997) Release of Isoprostanes by Human Pulmonary Artery in Organ Culture: A Cyclo-oxygenase and Nitric Oxide Dependent Pathway. Biochemical and Biophysical Research Communications 233:3, 668-672
CrossRef395
Jason D. Morrow, L.Jackson Roberts. (1997) The isoprostanes: Unique bioactive products of lipid peroxidation. Progress in Lipid Research 36:1, 1-21
CrossRef396
Karen B. Jourdan, Timothy W. Evans, Nicholas P. Curzen, Jane A. Mitchell. (1997) Evidence for a dilator function of 8-iso prostaglandin F 2α in rat pulmonary artery. British Journal of Pharmacology 120:7, 1280-1285
CrossRef397
Inger Thune, Eiliv Lund. (1997) The influence of physical activity on lung-cancer risk: A prospective study of 81,516 men and women. International Journal of Cancer 70:1, 57-62
CrossRef398
Barry Halliwell. (1997) Antioxidants and Human Disease: A General Introduction. Nutrition Reviews 55:1, S44-S49
CrossRef399
Joseph, Anne M., Norman, Suzanne M., Ferry, Linda H., Prochazka, Allan V., Westman, Eric C., Steele, Bonnie G., Sherman, Scott E., Cleveland, Minot, Antonuccio, David O., Hartman, Neil, McGovern, Paul G., . (1996) The Safety of Transdermal Nicotine as an Aid to Smoking Cessation in Patients with Cardiac Disease. New England Journal of Medicine 335:24, 1792-1798
Full Text400
M. Peet, J.D.E. Laugharne, J. Mellor, C.N. Ramchand. (1996) Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. Prostaglandins, Leukotrienes and Essential Fatty Acids 55:1-2, 71-75
CrossRef401
C. Michael Stein, S. Bobo Tanner, Joseph A. Awad, L. Jackson Roberts, Jason D. Morrow. (1996) Evidence of free radical–mediated injury (isoprostane overproduction) in scleroderma. Arthritis & Rheumatism 39:7, 1146-1150
CrossRef402
Joseph A. Awad, L.J. Roberts, Raymond F. Burk, Jason D. Morrow. (1996) ISOPROSTANES—RROSTAGLANDIN-LIKE COMPOUNDS FORMED IN VIVO INDEPENDENTLY OF CYCLOOXYGENASE. Gastroenterology Clinics of North America 25:2, 409-427
CrossRef403
J Morrow. (1996) The isoprostanes Current knowledge and directions for future research. Biochemical Pharmacology 51:1, 1-9
CrossRef404
Irfan Rahman, William MacNee. (1996) Role of oxidants/antioxidants in smoking-induced lung diseases. Free Radical Biology and Medicine 21:5, 669-681
CrossRef
- Letters
