Correspondence
Familial Occurrence of Neurocardiogenic Syncope
N Engl J Med 1994; 331:1529December 1, 1994
- Article
To the Editor:
Cooper et al. (July 21 issue)1 described neurocardiogenic syncope in a mother and daughter. The authors stated that they were “not aware of a familial clustering of this disorder.” In fact, there have been several previous reports suggesting a genetic predisposition to neurocardiogenic syncope. A case-control study by Camfield and Camfield2 showed that among children with vasovagal (neurocardiogenic) syncope, a significant proportion had a parent or sibling with syncope, an association not seen in control subjects. In a study by Kleinknecht et al.3 of college students with vasovagal syncope, a significant familial association was seen. Talwar et al.4 described a mother and daughter with recurrent syncope associated with documented vagally mediated atrioventricular block.
4 ReferencesSteven L. Lewis, M.D.
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612Michael O'Toole, M.D.
Midwest Heart Research Foundation, Lombard, IL 601481
Cooper CJ ,Ridker P ,Shea J ,Creager MA . Familial occurrence of neurocardiogenic syncope. N Engl J Med 1994;331:205-205
Full Text | Web of Science | Medline2
Camfield PR ,Camfield CS . Syncope in childhood: a case control clinical study of the familial tendency to faint. Can J Neurol Sci 1990;17:306-308
Web of Science | Medline3
Kleinknecht RA ,Lenz J ,Ford G ,DeBerard S . Types and correlates of blood/injury-related vasovagal syncope. Behav Res Ther 1990;28:289-295
CrossRef | Web of Science | Medline4
Talwar KK ,Edvardsson N ,Varnauskas E . Paroxysmal vagally mediated AV block with recurrent syncope. Clin Cardiol 1985;8:337-340
CrossRef | Web of Science | Medline
- Citing Articles (1)
Citing Articles
1
Burcu Topcu, Figen Akalın. (2010) The autonomic nervous system dysregulation in response to orthostatic stress in children with neurocardiogenic syncope. Cardiology in the Young 20:02, 165
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