Images in Clinical Medicine

Kim Eagle, M.D., Editor

Primary Syphilis

Tai-Yuen Wong, M.D., and Martin C. Mihm, Jr., M.D.

N Engl J Med 1994; 331:1492December 1, 1994

• Slide

Article

Figure 1 Primary Syphilis.

Panel A shows a primary chancre of syphilis, which began as a papule, eroded and developed into a painless ulcer (arrows) with raised, firm, indurated borders and a clean smooth base. Histologically, it is characterized by superficial ulceration, plasma-cell infiltrates, endarteritis, and endothelial proliferation (Panel B, arrows). In Panel C silver staining reveals a spirochete 6 to 15 micrometers in length with regularly spaced spiral coils (arrow).

Kim Eagle, M.D.

Tai-Yuen Wong, M.D.
Martin C. Mihm, Jr., M.D.
Massachusetts General Hospital, Boston, MA 02114

Citing Articles (1)

Citing Articles

1. 1

   (1995) Syphilis and Coincidence. New England Journal of Medicine 332:17, 1175-1176
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