Original Article
Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death
N Engl J Med 1994; 330:1639-1644June 9, 1994
- Abstract
Background
Information on life expectancy and risk factors for early death among patients with sickle cell disease (sickle cell anemia, sickle cell-hemoglobin C disease, and the sickle cell-β-thalassemias) is needed to counsel patients, target therapy, and design clinical trials.
Methods
We followed 3764 patients who ranged from birth to 66 years of age at enrollment to determine the life expectancy and calculate the median age at death. In addition, we investigated the circumstances of death for all 209 adult patients who died during the study, and used proportional-hazards regression analysis to identify risk factors for early death among 964 adults with sickle cell anemia who were followed for at least two years.
Results
Among children and adults with sickle cell anemia (homozygous for sickle hemoglobin), the median age at death was 42 years for males and 48 years for females. Among those with sickle cell-hemoglobin C disease, the median age at death was 60 years for males and 68 years for females. Among adults with sickle cell disease, 18 percent of the deaths occurred in patients with overt organ failure, predominantly renal. Thirty-three percent were clinically free of organ failure but died during an acute sickle crisis (78 percent had pain, the chest syndrome, or both; 22 percent had stroke). Modeling revealed that in patients with sickle cell anemia, the acute chest syndrome, renal failure, seizures, a base-line white-cell count above 15,000 cells per cubic millimeter, and a low level of fetal hemoglobin were associated with an increased risk of early death.
Conclusions
Fifty percent of patients with sickle cell anemia survived beyond the fifth decade. A large proportion of those who died had no overt chronic organ failure but died during an acute episode of pain, chest syndrome, or stroke. Early mortality was highest among patients whose disease was symptomatic. A high level of fetal hemoglobin predicted improved survival and is probably a reliable childhood forecaster of adult life expectancy.
Media in This Article
Figure 1
Survival of Patients in the Cooperative Study of Sickle Cell Disease.Figure 2
Probability of Surviving for the Next 10 Years, According to Age, among Males and Females with Sickle Cell Anemia (SS), as Compared with Black Males and Females in the General Population.Article Activity
- Article
The life expectancy of patients with sickle cell disease has improved considerably since 1960, when Sir John Dacie described sickle cell disease as “essentially a disease of childhood.” “Indeed,” he wrote, “the mortality is high and relatively few patients reach adult life, even when the standard of medical care is high”1. In his 1973 review based on autopsies, Diggs estimated a median survival of 14.3 years, with 20 percent of the deaths occurring in the first 2 years of life, one third occurring before the fifth year of life, half between 5 and 30 years of age, and one sixth after the age of 302. In contrast, in the recent Cooperative Study of Sickle Cell Disease (CSSCD), approximately 85 percent of children and adolescents with sickle cell anemia (homozygous for sickle hemoglobin) and 95 percent of patients with sickle cell-hemoglobin C disease (heterozygous for hemoglobin S and C) survived to 20 years of age3. Among the patients less than 20 years of age in that series, mortality peaked between 1 and 3 years of age; the primary cause of death was infection -- predominantly Streptococcus pneumoniae sepsis. A low level of fetal hemoglobin, a low level of total hemoglobin, and an elevated base-line white-cell count were associated with an increased risk of death.
In most studies of mortality among adult patients, the age at death has been determined either from autopsy data or from clinical records. The clinical events leading to death have been recorded only sporadically. In the Jamaican studies by Thomas et al., the acute chest syndrome was the principal cause of death after 10 years of age,4 with chronic organ damage such as renal or cardiac failure, cerebrovascular accident, and complications of pregnancy noted as concomitant causes of death. Powars and colleagues5 described similar findings in a cohort of patients followed in Los Angeles for 25 years, noting that survival estimates based on this group may have been influenced by changes in clinical practice over time. For example, they suggest that the high mortality they observed among women with sickle cell anemia reflected the high mortality among pregnant women before 1975. Accurate knowledge is needed about the contemporary mortality rate, the events that occur shortly before death, and the clinical conditions that are associated with an increased risk of death. Such information is of great importance in counseling patients, in anticipating dangerous clinical situations, and in designing targeted therapy and clinical trials. We undertook a prospective analysis of deaths among patients in the CSSCD, with emphasis on the risk factors for death in patients over 20 years of age.
Methods
The design of the CSSCD is described elsewhere6. The CSSCD is a prospective study of the clinical course of sickle cell disease in which more than 3764 patients were enrolled from birth to 66 years of age, at 23 clinical centers throughout the continental United States (Table 1Table 1
Characteristics of Patients in the Cooperative Study of Sickle Cell Disease.). Patients were enrolled at these centers between September 1978 and 1988 and were seen at regular intervals for laboratory evaluation and physical examination. At enrollment, the genotype was confirmed by review of the hematologic data and by quantitative hemoglobin electrophoresis performed at the Centers for Disease Control and Prevention7. Starting late in 1984, α-globin gene mapping was performed in patients with sickle cell anemia by Dr. Stephen H. Embury at the University of California, San Francisco8,9. Consent was obtained from all patients, their parents, or their legal guardians.The laboratory results analyzed in this report were obtained at routine visits, not during acute illness. All acute and chronic complications were documented at the centers. Deaths were reported on a form that was completed by the center investigator, regardless of whether deaths occurred at the study center or elsewhere; this form included narrative information about the relevant clinical findings and laboratory data, as well as the death certificate. When available, autopsy reports were also provided.
For all patients with sickle cell anemia or sickle cell-hemoglobin C disease we used proportional-hazards regression and the 2L program of BMDP to model age at death rather than the length of time from enrollment to death10,11. The Cnaan and Ryan approach10 is appropriate for analyses of data in studies, like this one, in which patients enter and leave the study cohort and observation begins after the onset of the disease. According to this method, a particular patient contributes to the population at risk for a given death only if that patient is enrolled in the study at the age at which that death occurred.
The probability of survival 10 years after enrollment was estimated as P2/P1, with P1 denoting the proportion of the study population alive at the beginning of the decade and P2 the proportion alive at the end. The proportions were estimated from Kaplan-Meier plots (discussed below).
Because the causes of and risk factors for early death in the children and adolescents in this study had already been reported,3 we concentrated on the risk factors for early death among the patients over 20 years of age. We investigated the circumstances of death in the 209 patients with sickle cell disease (all genotypes) who were 20 years of age or older when they died. For each patient, we reviewed the complete roster of forms recording acute and chronic complications and scheduled visits to the medical center, the death form, and when available, the final hospital discharge summary and autopsy report. On the basis of this review, patients were classified as either having or not having clinically diagnosed chronic organ failure before they died. This classification was based on either the CSSCD working definition of renal failure (a 20 percent increase in the base-line creatinine concentration and a creatinine clearance rate below 100 ml per minute) or the clinical diagnosis of chronic congestive heart failure or chronic debilitating stroke by the local investigator. The CSSCD did not have a specific working definition of chronic pulmonary failure. Acute terminal organ failure and evidence at autopsy of organ damage that was not recognized during life were not criteria for chronic organ failure. Patients without chronic organ failure were classified according to their terminal event. Commonly, a death form describing other acute events (e.g., an episode of pain or the acute chest syndrome) was the only event form submitted, particularly for patients who died outside the center hospital where they were enrolled.
We examined the steady-state laboratory values (the average of yearly routine measurements) and clinical events. Data collected during the last year of life or follow-up were excluded so as to avoid biasing the results with changes related to the ultimate cause of death. We excluded patients without at least one year of observation before the excluded (premortem) year (70 patients) and those for whom data were incomplete (94 patients). The models are based on the data on 964 patients with sickle cell anemia, 85 of whom died. Each potential risk factor was examined in a separate regression analysis. Each statistically significant laboratory variable was then categorized in a variety of ways (e.g., by quartiles or quintiles) to identify the values that contributed to the significant effect.
Likelihood ratios were used for all statistical tests. All the P values presented are two-tailed.
Results
Survival
Kaplan-Meier survival curves for children and adults with sickle cell anemia (1313 females and 1229 males) or sickle cell-hemoglobin C disease (427 females and 417 males) are shown in Figure 1Figure 1
Survival of Patients in the Cooperative Study of Sickle Cell Disease.. Among patients with each phenotype, females survived longer than males (P = 0.004 by Cox regression), and patients with sickle cell-hemoglobin C disease survived longer than those with sickle cell anemia (P<0.001 by Cox regression). The median age at death among patients with sickle cell anemia was 42 years for males and 48 years for females. Among patients with sickle cell-hemoglobin C disease, the corresponding ages were 60 and 68 years; the data on age at death among patients with sickle cell-hemoglobin C disease should be interpreted with some caution, however, since the number of deaths was relatively low in this group. The corresponding survival curves for blacks in the general population12 are included for comparison and show that life expectancy among patients with sickle cell anemia was decreased by 25 to 30 years. The improved survival of patients with sickle cell anemia who had fetal hemoglobin levels above the 75th percentile (>8.6 percent) is illustrated in Figure 1C.To investigate the relation between age and the risk of death in sickle cell disease, we analyzed the data according to decade of age and calculated the probability of surviving each decade (Figure 2Figure 2
Probability of Surviving for the Next 10 Years, According to Age, among Males and Females with Sickle Cell Anemia (SS), as Compared with Black Males and Females in the General Population.). The probability of surviving for 10 years dropped dramatically with age, particularly after the age of 20 years, when compared with similar data for blacks in the general population.Circumstances of Death
Because of the difficulty of ascertaining the exact cause of death in most cases, we focused on the general clinical status of the patients and the circumstances in which they died. The result of the classification is shown in Table 2Table 2
Circumstances of Death in 209 Patients with Sickle Cell Disease Who Were 20 Years of Age or Older at the Time of Death.. Thirty-seven percent of the patients underwent autopsies, and approximately 60 percent died outside the study center. For 38 of the patients who died without clinical evidence of chronic organ failure, there was insufficient information to classify their immediate circumstances of death. A small proportion of patients died of causes not related to sickle cell disease, including trauma and cancer. In these cases it was impossible to determine the extent to which the underlying hemoglobinopathy contributed to the death.Relatively few patients died with clinical evidence of chronic organ failure (renal failure, congestive heart failure, or chronic debilitating cerebrovascular accident). In some instances, the organ failure was attributable to causes other than sickle cell disease, but undoubtedly complicated by it. Because arterial-blood gas measurements and pulmonary-function studies were not required for all patients, there was no working definition of chronic pulmonary failure in this study.
A large number of patients had no overt chronic organ-system failure and died relatively suddenly and unexpectedly, presumably as a complication of a sickle cell crisis. Death occurred in the course of a painful episode in 45 patients, 20 of whom had simultaneous acute chest syndrome. Nine patients had acute chest syndrome alone. Acute stroke occurred before death in 15 patients, with documented hemorrhage in 11. Although 13 of the patients without chronic organ failure died of infection, the infections were varied (Escherichia coli, Staphylococcus aureus, human immunodeficiency virus, tuberculosis, malaria, pneumococcus, and hepatitis), in contrast to the almost universal occurrence of pneumococcal sepsis in children under five years of age who died of infections.
Risk Factors for Early Death
Although males were at greater risk for early death than females, when sex was factored into the analysis of each of the other risk factors, no significant interaction was found (data not shown). Thus, there was no evidence that the risk factors for early death differed according to sex.
The patients with more symptomatic disease were at higher risk of early death. Mortality varied with the following acute and chronic conditions: renal insufficiency, acute painful episodes, acute anemic episodes, seizures, and the acute chest syndrome (Table 3Table 3
Acute and Chronic Conditions as Risk Factors for Early Death in Patients with Sickle Cell Anemia Who Were 20 Years of Age or Older.).The risk of early death was inversely associated with level of fetal hemoglobin (Table 4Table 4
Laboratory Values as Risk Factors for Early Death in Patients with Sickle Cell Anemia Who Were 20 Years of Age or Older.). This association was dramatically illustrated by the enhanced survival of patients with sickle cell anemia who had fetal hemoglobin levels above the 75th percentile (Figure 1). Differences within the group with values above the 75th percentile could not be determined because of the small number of deaths.Two other laboratory values were found to be associated with mortality (Table 4). In each case, the increase in mortality was associated only with values at the end of the distribution; there was no smooth trend of mortality increasing with the laboratory value. Patients with sickle cell anemia who had hemoglobin values below the 10th percentile ( ≤ 7.1 g per deciliter) had a slightly higher risk of death than all other patients (2.8 vs. 1.1 deaths per 100 person-years). Similarly, patients with sickle cell anemia who had an elevated white-cell count (15,100 per cubic millimeter) had a slightly higher risk of death (2.2 vs. 1.2 per 100 person-years). In each case, if the 10 percent of patients in each of these groups was excluded from analysis, no significant associations were found between mortality and the hemoglobin level or the white-cell count.
There was no demonstrable relation between mortality and the presence or absence of α-thalassemia. A binary indicator for α-thalassemia did not make a statistically significant contribution to the proportional-hazards model. The delay in collecting data on α-thalassemia interfered with our ability to perform a more rigorous analysis of this variable.
Multiple Regression Analysis
Since the incidence of clinical conditions may vary with laboratory profile, and since two or more conditions can occur in the same patient, there may be redundancy in the results of the risk-factor modeling by single regression analysis. Therefore, the laboratory values and clinical events associated with significant variation in the risk of death were combined in a multivariate model, and backward elimination was used to reduce the model to the subset of factors that made statistically significant contributions to the variation in mortality (Table 5Table 5
Risk Factors for Early Death in Patients with Sickle Cell Anemia Who Were 20 Years of Age or Older.). This model showed that the fetal hemoglobin level, renal insufficiency, acute chest syndrome, seizures, and white-cell count were significant risk factors.Discussion
This report presents a snapshot of the life expectancy of patients with sickle cell disease in the United States during the 1980s. In contrast to the widely held assumption that patients with sickle cell anemia rarely survive to adulthood, the median age at death among such patients was 42 years for males and 48 years for females. This represents a decrease of roughly 25 to 30 years in life expectancy, as compared with that of the black American population in general. Among patients with sickle cell-hemoglobin C disease, the median age at death was 60 years for males and 68 years for females. The longer survival of females with both types of hemoglobinopathy is typical of the findings in black American and other normal populations.
The pattern of mortality varies with age. We have already reported that the peak incidence of death among children with sickle cell anemia occurred between 1 and 3 years of age and that deaths among patients less than 20 years of age were predominantly caused by pneumococcal sepsis3. We anticipate that the recent acceptance of universal screening of newborns and the early administration of prophylactic penicillin to infants with sickle cell anemia will mean that more than 85 percent of such children will survive to 20 years of age and that overall survival will be even greater than we report here. Unfortunately, the risk of death among those over 20 years of age is not easily assigned to a single preventable cause.
In this study, adults with sickle cell anemia had a high mortality rate, with few surviving into their 60s. The circumstances of their deaths were quite varied. Eighteen percent of the deaths occurred in chronically ill patients with clinically obvious organ-system failure (renal failure, congestive heart failure, or chronic debilitating cerebrovascular accident). Although a minority of these patients had other specific factors that contributed to organ failure (such as systemic lupus erythematosus, renal tuberculosis, and congenital valvular heart disease), sickling was undoubtedly an important accelerator of organ destruction. Thirty-three percent of deaths occurred in relatively healthy patients who did not have overt chronic organ failure but died during a classic sickle crisis. Seventy-eight percent of these patients died during an acute painful episode or an episode of acute chest syndrome. These patients had surely experienced and survived such episodes when they were younger, but they were not able to tolerate them in later years.
The precise causes of death under these circumstances remain elusive, probably involving bone marrow and fat embolization,13-16 excessive narcotization,17 the pain event itself,18 or a combination of these factors. Adults, even those who appear relatively fit, are susceptible to cardiovascular collapse and acute multiorgan-system failure and may die suddenly during episodes of acute pain, the chest syndrome, or both. This finding illustrates the need for more thorough study of acutely ill patients; perhaps some such unexpected deaths can be prevented. The other 22 percent of these “healthy” patients with sickle cell anemia died of acute stroke; all the strokes for which a type was specified were acute hemorrhages.
The clinically well patients were not all as well as they seemed. As Powars and colleagues have described, vascular damage caused by sickling insidiously accumulates in varying degrees5. Our ability to prevent early deaths hinges on the ability to identify patients at high risk so they can be treated before fatal, often silent, vascular lesions develop. We examined clinical and laboratory data to determine whether we could identify adults at high risk for early death. We studied steady-state laboratory values using only those obtained at the time of routine visits rather than during acute illness. We studied steady-state clinical status by excluding events that occurred during the last year of life; we hoped thus to avoid biasing the results with changes associated directly with the cause of death. Our previous reports on this population described a wide range of degrees of clinical severity19. In this analysis, we found that the adult patients who had more symptoms of the disease were at increased risk of early death.
The important laboratory risk factors were a high white-cell count and a low fetal hemoglobin level. Patients with a white-cell count over 15,000 per cubic millimeter were at increased risk. This interesting finding is also well documented in the normal population and is independent of factors, such as smoking, that are known to raise the base-line white-cell count20. In this study we may simply have “rediscovered” this normal enigmatic observation, or may have identified a feature peculiar to sickle cell anemia, such as the relation between inflammatory cytokines and the endothelium, adhesive interactions between white cells and endothelium, or even interactions between white cells and sickle red cells. It is tempting to speculate that lowering very high white-cell counts may be therapeutic in sickle cell disease and that the beneficial effects of hydroxyurea and other cytotoxic chemotherapeutic agents that raise the fetal hemoglobin level may relate to their tendency to lower the white-cell count.
The most straightforward laboratory risk factor was the fetal hemoglobin level. Patients with high levels had an improved life expectancy. Although this result is no surprise, its documentation is of utmost importance. Of all the risk factors we identified in this study, the fetal hemoglobin level is the one known to be relatively stable throughout life21. Adults who had low levels of fetal hemoglobin as children are likely to die earlier than those who had high levels. The fetal hemoglobin level should be considered an important factor in selecting children for high-risk interventions such as bone marrow transplantation and long-term treatment with agents that stimulate the production of fetal hemoglobin.
Supported by the Cooperative Study of Sickle Cell Disease, a program of the Sickle Cell Disease Branch of the National Heart, Lung, and Blood Institute.
Source Information
From the Department of Medicine, Children's Hospital, the Dana-Farber Cancer Institute, and Harvard Medical School -- all in Boston (O.S.P.); New England Research Institute, Watertown, Mass. (D.J.B.); the Department of Medicine, Duke University School of Medicine, Durham, N.C. (W.F.R.); the Department of Medicine, Medical College of Georgia, Augusta (P.F.M.); the Department of Medicine, Center for Sickle Cell Disease, Howard University, Washington, D.C. (O.C.); the Hematology-Oncology Section, Jackson Veterans Affairs Medical Center, and the Department of Medicine, University of Mississippi School of Medicine -- both in Jackson (M.H.S.); and the Hematology Division, Texas Tech University Health Science Center, Amarillo (P.P.K.).
Address reprint requests to Dr. Platt at the Department of Laboratory Medicine, Children's Hospital, 300 Longwood Ave., Boston, MA 02115.
The investigators who participated in this study are listed in the Appendix.
Appendix
The following investigators participated in the Cooperative Study of Sickle Cell Disease: R. Johnson, Alta Bates Hospital, Oakland, Calif.; L. McMahon, Boston City Hospital, Boston; O. Platt, Children's Hospital, Boston; F. Gill and K. Ohene Frempong, Children's Hospital, Philadelphia; G. Bray, J.F. Kelleher, and S. Leikin, Children's Hospital National Medical Center, Washington, D.C.; E. Vichinsky and B. Lubin, Children's Hospital, Oakland, Calif.; A. Bank and S. Piomelli, Columbia Presbyterian Hospital, New York; W. Rosse, J. Falletta, and T.R. Kinney, Duke University, Durham, N.C.; L. Lessin, George Washington University, Washington, D.C.; J. Smith and Y. Khakoo, Harlem Hospital, New York; R.B. Scott, O. Castro, and C. Reindorf, Howard University, Washington, D.C.; H. Dosik, S. Diamond, and R. Bellevue, Interfaith Medical Center, Brooklyn, N.Y.; W. Wang and J. Wilimas, LeBonheur Children's Hospital, Memphis, Tenn.; P. Milner, Medical College of Georgia, Augusta; A. Brown, S. Miller, R. Rieder, and P. Gillette, State University of New York Downstate Medical Center, Brooklyn; W. Lande, S. Embury, and W. Mentzer, San Francisco General Hospital, San Francisco; D. Wethers and R. Grover, St. Luke's-Roosevelt Medical Center, New York; M. Koshy and N. Talishy, University of Illinois, Chicago; C. Pegelow and P. Klug, University of Miami, Miami; M. Steinberg, University of Mississippi, Jackson; A. Kraus, University of Tennessee, Memphis; H. Zarkowsky, Washington University, St. Louis; C. Dampier, Wyler Children's Hospital, Chicago; H. Pearson and A.K. Ritchey, Yale University, New Haven, Conn.; S. McKinlay, D. Gallagher, and D. Brambilla, New England Research Institute, Watertown, Mass.; and M. Gaston and C. Reid, National Heart, Lung, and Blood Institute, Bethesda, Md.
- References
References
1
Dacie JV. The haemolytic anaemias: congenital and acquired. Part I -- the congenital anaemias. 2nd ed. New York: Grune & Stratton, 1960.
2
Diggs LM. Anatomic lesions in sickle cell disease. In: Abramson H, Bertles JF, Wethers DL, eds. Sickle cell disease: diagnosis, management, education, and research. St. Louis: C.V. Mosby, 1973:189-229.
3
Leikin SL ,Gallagher D ,Kinney TR ,Sloane D ,Klug P ,Rida W . Mortality in children and adolescents with sickle cell disease. Pediatrics 1989;84:500-508
Web of Science | Medline4
Thomas AN ,Pattison C ,Serjeant GR . Causes of death in sickle-cell disease in Jamaica. BMJ 1982;285:633-635
CrossRef | Web of Science | Medline5
Powars D ,Chan LS ,Schroeder WA . The variable expression of sickle cell disease is genetically determined. Semin Hematol 1990;27:360-376
Web of Science | Medline6
Gaston M ,Rosse WF . The cooperative study of sickle cell disease: review of study design and objectives. Am J Pediatr Hematol Oncol 1982;4:197-201
Medline7
Steinberg MH ,Rosenstock W ,Coleman MB , et al. Effects of thalassemia and microcytosis on the hematologic and vasoocclusive severity of sickle cell anemia. Blood 1984;63:1353-1360
Web of Science | Medline8
Dozy AM ,Kan YW ,Embury SH , et al. α-Globin gene organisation in blacks precludes the severe form of α-thalassaemia. Nature 1979;280:605-607
CrossRef | Web of Science | Medline9
Embury SH ,Miller JA ,Dozy AM ,Kan YW ,Chan V ,Todd D . Two different molecular organizations account for the single α-globin gene in the α-thalassemia-2 genotype. J Clin Invest 1980;66:1319-1325
CrossRef | Web of Science | Medline10
Cnaan A ,Ryan L . Survival analysis in natural history studies of disease. Stat Med 1989;8:1255-1268
CrossRef | Web of Science | Medline11
Dixon WJ, ed. BMDP statistical software manual. Vol. 2. Berkeley: University of California, 1992.
12
National Center for Health Statistics. Vital statistics of the United States, 1985. Vol. II. Mortality. Part A. Section 6, Life tables. Washington, D.C.: Government Printing Office, 1988. (DHHS publication no. (PHS) 88-1101).
13
Haupt HM ,Moore GW ,Bauer TW ,Hutchins GM . The lung in sickle cell disease. Chest 1982;81:332-337
CrossRef | Web of Science | Medline14
Charache S ,Page DL . Infarction of bone marrow in the sickle cell disorders. Ann Intern Med 1967;67:1195-1200
Web of Science | Medline15
Shapiro MP ,Hayes JA . Fat embolism in sickle cell disease: report of a case with brief review of the literature. Arch Intern Med 1984;144:181-182
CrossRef | Web of Science | Medline16
Hutchinson RM ,Merrick MV ,White JM . Fat embolism in sickle cell disease. J Clin Pathol 1973;26:620-622
CrossRef | Web of Science | Medline17
Cole TB ,Sprinkle RH ,Smith SJ ,Buchanan GR . Intravenous narcotic therapy for children with severe sickle cell pain crisis. Am J Dis Child 1986;140:1255-1259
Web of Science | Medline18
Parfrey NA ,Moore W ,Hutchins GM . Is pain crisis a cause of death in sickle cell disease? Am J Clin Pathol 1985;84:209-212
Web of Science | Medline19
Platt OS ,Thorington BD ,Brambilla DJ , et al. Pain in sickle cell disease: rates and risk factors. N Engl J Med 1991;325:11-16
Full Text | Web of Science | Medline20
de Labry LO ,Campion EW ,Glynn RJ ,Vokonas PS . White blood cell count as a predictor of mortality: results over 18 years from the Normative Aging Study. J Clin Epidemiol 1990;43:153-157
CrossRef | Web of Science | Medline21
Odenheimer DJ ,Whitten CF ,Rucknagel DA ,Sarnaik SA ,Sing CF . Stability over time of hematological variables in 197 children with sickle cell anemia. Am J Med Genet 1984;18:461-470
CrossRef | Web of Science | Medline
- Citing Articles (584)
Citing Articles
1
Thomas B. Bartnikas, Clarissa C. Parker, Riyan Cheng, Dean R. Campagna, Jackie E. Lim, Abraham A. Palmer, Mark D. Fleming. (2012) QTLs for murine red blood cell parameters in LG/J and SM/J F2 and advanced intercross lines. Mammalian Genome
CrossRef2
Ceri Hirst, Lorna Williamson, Ceri Hirst. 2012. Preoperative blood transfusions for sickle cell disease. .
CrossRef3
Serena Dovey, Lakshmanan Krishnamurti, Joseph Sanfilippo, Sriya Gunawardena, Patricia Mclendon, Mary Campbell, Sandra Alway, Brenda Efymow, Clarisa Gracia. (2012) Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report. Journal of Assisted Reproduction and Genetics
CrossRef4
Julie A. Wolfson, Sheree M. Schrager, Rachna Khanna, Thomas D. Coates, Michele D. Kipke. (2012) Sickle cell disease in California: Sociodemographic predictors of emergency department utilization. Pediatric Blood & Cancer 58:1, 66-73
CrossRef5
Jean L. Raphael, Brigitta U. Mueller, Marc A. Kowalkowski, Suzette O. Oyeku. (2012) Shorter hospitalization trends among children with sickle cell disease. Pediatric Blood & Cancern/a-n/a
CrossRef6
Esther P. Verduin, Anneke Brand, Henk Schonewille. (2012) Is Female Sex a Risk Factor for Red Blood Cell Alloimmunization After Transfusion? A Systematic Review. Transfusion Medicine Reviews
CrossRef7
Hong Zhao, Eric S. G. Shaqfeh, Vivek Narsimhan. (2012) Shear-induced particle migration and margination in a cellular suspension. Physics of Fluids 24:1, 011902
CrossRef8
J Freed, J Talano, T Small, A Ricci, M S Cairo. (2011) Allogeneic cellular and autologous stem cell therapy for sickle cell disease: ‘whom, when and how’. Bone Marrow Transplantation
CrossRef9
Adetoro A Adegoke, Eugene J Kongnyuy, Adetoro A Adegoke. 2011. Iron supplementation for sickle cell disease during pregnancy. .
CrossRef10
Esra Guzeldemir, Hilal Uslu Toygar, Can Boga, Ulkem Cilasun. (2011) Dental and periodontal health status of subjects with sickle cell disease. Journal of Dental Sciences 6:4, 227-234
CrossRef11
Mark E. Swanson, Scott D. Grosse, Roshni Kulkarni. (2011) Disability Among Individuals with Sickle Cell Disease. American Journal of Preventive Medicine 41:6, S390-S397
CrossRef12
Lou Ella V. Taylor, Nancy A. Stotts, Janice Humphreys, Marsha J. Treadwell, Christine Miaskowski. (2011) A Biopsychosocial-Spiritual Model of Chronic Pain in Adults with Sickle Cell Disease. Pain Management Nursing
CrossRef13
S. Shenoy. (2011) Hematopoietic Stem Cell Transplantation for Sickle Cell Disease: Current Practice and Emerging Trends. Hematology 2011:1, 273-279
CrossRef14
V. G. Sankaran. (2011) Targeted Therapeutic Strategies for Fetal Hemoglobin Induction. Hematology 2011:1, 459-465
CrossRef15
Nicolas Prost, Pablo Bartolucci, Filippo Boroli, Julien Moroch, Frédéric Galactéros, Christian Brun-Buisson, Arnaud W. Thille. (2011) Extreme acute anemia in an adult sickle cell disease patient: look at the spleen. Intensive Care Medicine
CrossRef16
J. Xu, C. Peng, V. G. Sankaran, Z. Shao, E. B. Esrick, B. G. Chong, G. C. Ippolito, Y. Fujiwara, B. L. Ebert, P. W. Tucker, S. H. Orkin. (2011) Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing. Science 334:6058, 993-996
CrossRef17
K. M. Musallam, V. G. Sankaran, M. D. Cappellini, L. Duca, D. G. Nathan, A. T. Taher. (2011) Fetal hemoglobin levels and morbidity in untransfused patients with -thalassemia intermedia. Blood
CrossRef18
A. D. Campbell, S. Cui, L. Shi, R. Urbonya, A. Mathias, K. Bradley, K. O. Bonsu, R. R. Douglas, B. Halford, L. Schmidt, D. Harro, D. Giacherio, K. Tanimoto, O. Tanabe, J. D. Engel. (2011) Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proceedings of the National Academy of Sciences 108:46, 18808-18813
CrossRef19
Allison E. Ashley-Koch, Emmanuel C. Okocha, Melanie E. Garrett, Karen Soldano, Laura M. De Castro, Jude C. Jonassaint, Eugene P. Orringer, James R. Eckman, Marilyn J. Telen. (2011) MYH9 and APOL1 are both associated with sickle cell disease nephropathy. British Journal of Haematology 155:3, 386-394
CrossRef20
C. Cajado, B.A.V. Cerqueira, F.D. Couto, J.P. Moura-Neto, W. Vilas-Boas, M.J. Dorea, I.M. Lyra, C.G. Barbosa, M.G. Reis, M.S. Goncalves. (2011) TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 56:2, 312-317
CrossRef21
Jason J. Sico, John Concato, Carolyn K. Wells, Albert C. Lo, Steven E. Nadeau, Linda S. Williams, Aldo J. Peixoto, Mark Gorman, John L. Boice, Dawn M. Bravata. (2011) Anemia Is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases
CrossRef22
Claire C. Sharpe, Swee L. Thein. (2011) Sickle cell nephropathy - a practical approach. British Journal of Haematology 155:3, 287-297
CrossRef23
David C. Rees, John S. Gibson. (2011) Biomarkers in sickle cell disease. British Journal of Haematologyno-no
CrossRef24
F. Angoulvant, S. Redant, L. Holvoet, B. Millet, A. Ferster, J. Andreu-Gallien. (2011) Prise en charge de la douleur des enfants drépanocytaires aux urgences: recommandations et état des lieux dans le Réseau Mère-Enfant de la francophonie. Réanimation
CrossRef25
Ambroise Wonkam, Alfred K. Njamnshi, Dora Mbanya, Jeanne Ngogang, Caryl Zameyo, Fru F. Angwafo. (2011) Acceptability of Prenatal Diagnosis by a Sample of Parents of Sickle Cell Anemia Patients in Cameroon (Sub-Saharan Africa). Journal of Genetic Counseling 20:5, 476-485
CrossRef26
Masanori Hayashi, Agustin Calatroni, Brittany Herzberg, Allison K. Ross, Henry E. Rice, Courtney Thornburg. (2011) Impact of Hydroxyurea on Perioperative Management and Outcomes in Children With Sickle Cell Anemia. Journal of Pediatric Hematology/Oncology 33:7, 487-490
CrossRef27
Susanna Bortolusso Ali, Michelle MooSang, Lesley King, Jennifer Knight-Madden, Marvin Reid. (2011) Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke. American Journal of Hematology 86:10, 846-850
CrossRef28
Swee Lay Thein. (2011) Genetic Modifiers of Sickle Cell Disease. Hemoglobin 35:5-6, 589-606
CrossRef29
Stephen P. Morgan. (2011) Can new optical techniques for in vivo imaging and flow cytometry of the microcirculation benefit sickle cell disease research?. Cytometry Part A 79A:10, 766-774
CrossRef30
Samuel O Anim, Robert C Strunk, Michael R DeBaun. (2011) Asthma morbidity and treatment in children with sickle cell disease. Expert Review of Respiratory Medicine 5:5, 635-645
CrossRef31
Thomas G. Day, Swee Lay Thein, Emma Drasar, Moira C. Dick, Susan E. Height, Sandra OʼDriscoll, David C. Rees. (2011) Changing Pattern of Hospital Admissions of Children With Sickle Cell Disease Over the Last 50 Years. Journal of Pediatric Hematology/Oncology 33:7, 491-495
CrossRef32
P W Hedrick. (2011) Population genetics of malaria resistance in humans. Heredity 107:4, 283-304
CrossRef33
Jerônimo Gonçalves Araújo, Carlos André Araújo-Melo, Osvaldo Alves de Menezes-Neto, Diego Fernandes Chagas da Silveira, Jailson Barros Correia, Rosana Cipolotti. (2011) Risk Factors for Acute Chest Syndrome in Patients From Low Socioeconomic Background. Journal of Pediatric Hematology/Oncology 33:7, 484-486
CrossRef34
G. Quéré, A. Tempescul, F. Couturaud, N. Paleiron, C. Leroyer, L. De Saint-Martin. (2011) Le syndrome thoracique aigu de l’adulte drépanocytaire. Revue de Pneumologie Clinique
CrossRef35
Bruce Ovbiagele, Robert J. Adams. (2011) Trends in comorbid sickle cell disease among stroke patients. Journal of the Neurological Sciences
CrossRef36
Kamal-Eldin Ahmed Abou-Elhamd. (2011) Otorhinolaryngological manifestations of sickle cell disease. International Journal of Pediatric Otorhinolaryngology
CrossRef37
Panagiotis Korovessis, Thomas Repantis. (2011) Massive septic pelvic osteolysis following revision total hip arthroplasty in a patient with sickle cell anemia: clinical presentation and review of the literature. European Journal of Orthopaedic Surgery & Traumatology
CrossRef38
S. Pandey, H. R. Pandey, R. M. Mishra, Sw. Pandey, R. Saxena. (2011) Increased Homocysteine Level in Indian Sickle Cell Anemia Patients. Indian Journal of Clinical Biochemistry
CrossRef39
Gavin Cho, Ian R Hambleton, Gavin Cho. 2011. Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease. .
CrossRef40
Helen Caird, Paul M. Camic, Veronica Thomas. (2011) The lives of adults over 30 living with sickle cell disorder. British Journal of Health Psychology 16:3, 542-558
CrossRef41
David J. Weatherall. (2011) The challenge of haemoglobinopathies in resource-poor countries. British Journal of Haematology 154:6, 736-744
CrossRef42
Rabindra N. Paul, Oswaldo L. Castro, Anita Aggarwal, Patricia A. Oneal. (2011) Acute chest syndrome: sickle cell disease. European Journal of Haematology 87:3, 191-207
CrossRef43
Jorge Mansilla-Soto, Isabelle Rivière, Michel Sadelain. (2011) Genetic strategies for the treatment of sickle cell anaemia. British Journal of Haematology 154:6, 715-727
CrossRef44
Robyn T. Cohen, Anusha Madadi, Morey A. Blinder, Michael R. DeBaun, Robert C. Strunk, Joshua J. Field. (2011) Recurrent, severe wheezing is associated with morbidity and mortality in adults with sickle cell disease. American Journal of Hematology 86:9, 756-761
CrossRef45
Carlo Brugnara, Lucia De Franceschi. 2011. Transfusion Therapy in β Thalassemia and Sickle Cell Disease. , 179-191.
CrossRef46
Banu Aygun, Nicole A. Mortier, Matthew P. Smeltzer, Jane S. Hankins, Russell E. Ware. (2011) Glomerular hyperfiltration and albuminuria in children with sickle cell anemia. Pediatric Nephrology 26:8, 1285-1290
CrossRef47
Elana Y. Poulter, Piotr Truszkowski, Alexis A. Thompson, Robert I. Liem. (2011) Acute chest syndrome is associated with history of asthma in hemoglobin SC disease. Pediatric Blood & Cancer 57:2, 289-293
CrossRef48
Gina A. Jae, Adam K. Lewkowitz, Joanna C. Yang, Liang Shen, Amal Rahman, Gustavo Del Toro. (2011) Barriers to conceiving sibling donors for sickle cell disease: perspectives from patients and parents. Ethnicity & Health 16:4-5, 431-445
CrossRef49
Roberto F. Machado, Mariana Hildesheim, Laurel Mendelsohn, Alan T. Remaley, Gregory J. Kato, Mark T. Gladwin. (2011) NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease. British Journal of Haematology 154:4, 512-520
CrossRef50
Gary R. Maslow, Abigail Haydon, Annie-Laurie McRee, Carol A. Ford, Carolyn T. Halpern. (2011) Growing Up With a Chronic Illness: Social Success, Educational/Vocational Distress. Journal of Adolescent Health 49:2, 206-212
CrossRef51
Clare Wykes, David C Rees. (2011) The safety and efficacy of hydroxycarbamide in infants with sickle cell anemia. Expert Review of Hematology 4:4, 407-409
CrossRef52
S. P. Perrine. (2011) Switching globin, raising red cells. Blood 118:4, 834-836
CrossRef53
I. Akinsheye, A. Alsultan, N. Solovieff, D. Ngo, C. T. Baldwin, P. Sebastiani, D. H. K. Chui, M. H. Steinberg. (2011) Fetal hemoglobin in sickle cell anemia. Blood 118:1, 19-27
CrossRef54
Teguh H Sasongko, Srikanth Nagalla, Samir K Ballas, Teguh H Sasongko. 2011. Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. .
CrossRef55
CDR Christopher Reddin, Elizabeth Cerrentano, Paula Tanabe. (2011) Sickle Cell Disease Management in the Emergency Department: What Every Emergency Nurse Should Know. Journal of Emergency Nursing 37:4, 341-345
CrossRef56
Ward Hagar, Claudia R. Morris. 2011. Adults with Sickle-Cell Disease: Implications of Increasing Longevity. , 115-140.
CrossRef57
Julie A. Panepinto, Sylvia Torres, James W. Varni. (2011) Development of the PedsQL™ sickle cell disease module items: qualitative methods. Quality of Life Research
CrossRef58
E. R. Macari, C. H. Lowrey. (2011) Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood 117:22, 5987-5997
CrossRef59
Ping An, Emily A. Barron-Casella, Robert C. Strunk, Robert G. Hamilton, James F. Casella, Michael R. DeBaun. (2011) Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. Journal of Allergy and Clinical Immunology 127:6, 1440-1446
CrossRef60
Valya Ramakrishnan, Betty S. Pace. (2011) Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway. Blood Cells, Molecules, and Diseases 47:1, 12-22
CrossRef61
Mary W. Byrne, Elana Evan, Lorie S. Goshin, Matthew D. Erlich, Jackie H.J. Kim, John M. Saroyan, Lonnie K. Zeltzer. (2011) Parent self-efficacy for managing pain in seriously ill children and adolescents nearing end of life. Palliative and Supportive Care 9:02, 137-147
CrossRef62
Wally R Smith. (2011) Pain in sickle cell disease: the future of acute treatment. Expert Review of Hematology 4:3, 237-239
CrossRef63
Amy Sobota, Ellis J. Neufeld, Philippa Sprinz, Matthew M. Heeney. (2011) Transition from pediatric to adult care for sickle cell disease: Results of a survey of pediatric providers. American Journal of Hematology 86:6, 512-515
CrossRef64
Wally R. Smith, Samir K. Ballas, William F. McCarthy, Robert L. Bauserman, Paul S. Swerdlow, Martin H. Steinberg, Myron A. Waclawiw, . (2011) The Association Between Hydroxyurea Treatment and Pain Intensity, Analgesic Use, and Utilization in Ambulatory Sickle Cell Anemia Patients. Pain Medicine 12:5, 697-705
CrossRef65
Patrick T McGann, Russell E Ware. (2011) Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain?. Current Opinion in Hematology 18:3, 158-165
CrossRef66
Clément Tassel, Cécile Arnaud, Marc Kulpa, Emmanuelle Fleurence, Annie Kandem, Fouad Madhi, Françoise Bernaudin, Christophe Delacourt. (2011) Leukocytosis is a risk factor for lung function deterioration in children with sickle cell disease. Respiratory Medicine 105:5, 788-795
CrossRef67
Santosh Saraf, Mohammed Farooqui, Giovanni Infusino, Bharvi Oza, Seema Sidhwani, Michel Gowhari, Stephen Vara, Weihua Gao, Lani Krauz, Donald Lavelle, Joseph DeSimone, Robert Molokie, Yogen Saunthararajah. (2011) Standard clinical practice underestimates the role and significance of erythropoietin deficiency in sickle cell disease. British Journal of Haematology 153:3, 386-392
CrossRef68
Paula Tanabe, Adeboye Ogunseitan. (2011) Understanding and meeting the hospitalist's challenge: Caring for adults with sickle cell disease. Journal of Hospital Medicine 6:5, 245-247
CrossRef69
G Schaefer, Bruce Buehler. 2011. Life Care Planning for Children with Genetic Disorders. , 679-696.
CrossRef70
Pallav Bhatnagar, Shirley Purvis, Emily Barron-Casella, Michael R DeBaun, James F Casella, Dan E Arking, Jeffrey R Keefer. (2011) Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients. Journal of Human Genetics 56:4, 316-323
CrossRef71
Monika Hurtova, Dora Bachir, Ketty Lee, Julien Calderaro, Thomas Decaens, Michael D. Kluger, Elie Serge Zafrani, Daniel Cherqui, Ariane Mallat, Frédéric Galactéros, Christophe Duvoux. (2011) Transplantation for liver failure in patients with sickle cell disease: Challenging but feasible. Liver Transplantation 17:4, 381-392
CrossRef72
J. Zhu, K. Chin, W. Aerbajinai, C. Trainor, P. Gao, G. P. Rodgers. (2011) Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cells. Blood 117:11, 3045-3052
CrossRef73
Julie A. Wolfson, Sheree M. Schrager, Thomas D. Coates, Michele D. Kipke. (2011) Sickle-cell disease in California: A population-based description of emergency department utilization. Pediatric Blood & Cancer 56:3, 413-419
CrossRef74
Sheethal D. Reddy, Christopher L. Edwards, Mary Wood, Keisha O’Garo, Kai Morgan, LeKisha Edwards, Chanté Wellington, Camela S. McDougald, Miriam Feliu, Janice McNeil, Keith E. Whitfield. (2011) Body Image in a Sample of Adult African American Males and Females with Sickle Cell Disease (SCD). Journal of African American Studies 15:1, 115-119
CrossRef75
Mary M. Reagan, Michael R. DeBaun, Melissa J. Frei-Jones. (2011) Multi-modal intervention for the inpatient management of sickle cell pain significantly decreases the rate of acute chest syndrome. Pediatric Blood & Cancer 56:2, 262-266
CrossRef76
Davoud Mohtat, Rosemary Thomas, Zangfang Du, Yaa Boakye, Thomas Moulton, Catherine Driscoll, Robert Woroniecki. (2011) Urinary transforming growth factor beta-1 as a marker of renal dysfunction in sickle cell disease. Pediatric Nephrology 26:2, 275-280
CrossRef77
Robert P. Hebbel. (2011) Reconstructing sickle cell disease: A data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine. American Journal of Hematology 86:2, 123-154
CrossRef78
J. Makani, S. Menzel, S. Nkya, S. E. Cox, E. Drasar, D. Soka, A. N. Komba, J. Mgaya, H. Rooks, N. Vasavda, G. Fegan, C. R. Newton, M. Farrall, S. Lay Thein. (2011) Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia. Blood 117:4, 1390-1392
CrossRef79
Ersi Voskaridou, Eleni Plata, Marousa Douskou, Anastasia Sioni, Efrosini Mpoutou, Dimitrios Christoulas, Maria Dimopoulou, Evangelos Terpos. (2011) Deferasirox effectively decreases iron burden in patients with double heterozygous HbS/β-thalassemia. Annals of Hematology 90:1, 11-15
CrossRef80
R. K. Ohls. (2011) Core Concepts: The Biology of Hemoglobin. NeoReviews 12:1, e29-e38
CrossRef81
Emily Riehm Meier, Colleen Byrnes, Maxine Weissman, Pierre Noel, Naomi L.C. Luban, Jeffery L. Miller. (2011) Expression patterns of fetal hemoglobin in sickle cell erythrocytes are both patient- and treatment-specific during childhood. Pediatric Blood & Cancer 56:1, 103-109
CrossRef82
Coretta M. Jenerette, Cheryl Brewer, Ashley N. Leak. (2011) Self-Care Recommendations of Middle-Aged and Older Adults with Sickle Cell Disease. Nursing Research and Practice 2011, 1-5
CrossRef83
Suzanne Forrest, Ashley Kim, Judith Carbonella, Farzana Pashankar. (2011) Proteinuria is associated with elevated tricuspid regurgitant jet velocity in children with sickle cell disease. Pediatric Blood & Cancern/a-n/a
CrossRef84
Ahmed H. Al-Salem. (2011) Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy. ISRN Hematology 2011, 1-7
CrossRef85
Amanda K. Dickerson, Jennifer Klima, Melissa M. Rhodes, Sarah H. O'Brien. (2011) Young adults with SCD in US children's hospitals: Are they different from adolescents?. Pediatric Blood & Cancern/a-n/a
CrossRef86
Laura J. Norton, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley. (2011) Cellular Reprogramming toward the Erythroid Lineage. International Journal of Cell Biology 2011, 1-6
CrossRef87
Abolfazl Najaf-Zadeh, Francis Leclerc. (2011) Noninvasive positive pressure ventilation for acute respiratory failure in children: a concise review. Annals of Intensive Care 1:1, 15
CrossRef88
Paul G. Firth, Kristen N. McMillan, Charles M. Haberkern, Myron Yaster, Michael A. Bender, Salvatore R. Goodwin. (2011) A survey of perioperative management of sickle cell disease in North America. Pediatric Anesthesia 21:1, 43-49
CrossRef89
Marsha Treadwell, Joseph Telfair, Robert W. Gibson, Shirley Johnson, Ifeyinwa Osunkwo. (2011) Transition from pediatric to adult care in sickle cell disease: Establishing evidence-based practice and directions for research. American Journal of Hematology 86:1, 116-120
CrossRef90
Daniel Lorch, Daniel Spevack, Jane Little. (2011) An Elevated Estimated Pulmonary Arterial Systolic Pressure, Whenever Measured, Is Associated with Excess Mortality in Adults with Sickle Cell Disease. Acta Haematologica 125:4, 225-229
CrossRef91
Constance L. Monitto, Sabine Kost-Byerly, Myron Yaster. 2011. Pain Management. , 418-451.
CrossRef92
Alden Chesney, David Good, Marciano Reis. 2011. Clinical Utility of Flow Cytometry in the Study of Erythropoiesis and Nonclonal Red Cell Disorders. , 311-332.
CrossRef93
Nada Basit, Harry Wechsler. (2011) Prediction of Enzyme Mutant Activity Using Computational Mutagenesis and Incremental Transduction. Advances in Bioinformatics 2011, 1-9
CrossRef94
Finn Hawkins, Noelle Ebel, George P. Sorescu, Lillian McMahon, Philippa Sprinz, Elizabeth S. Klings. (2011) Keeping it in the family: Three relatives with HbSC disease and simultaneous acute pulmonary emboli. American Journal of Hematologyn/a-n/a
CrossRef95
Michael J. Kelly, Brian W. Pennarola, Angie Mae Rodday, Susan K. Parsons, . (2011) Health-related quality of life (HRQL) in children with sickle cell disease and thalassemia following hematopoietic stem cell transplant (HSCT). Pediatric Blood & Cancern/a-n/a
CrossRef96
Jeffrey D. Lebensburger, Scott T. Miller, Thomas H. Howard, James F. Casella, R. Clark Brown, Ming Lu, Rathi V. Iyer, Sharada Sarnaik, Zora R. Rogers, Winfred C. Wang, . (2011) Influence of severity of anemia on clinical findings in infants with sickle cell anemia: Analyses from the BABY HUG study. Pediatric Blood & Cancern/a-n/a
CrossRef97
J. Bradley Ball, Samina Y. Khan, Nathan J.D. McLaughlin, Marguerite R. Kelher, Rachelle Nuss, Laura Cole, Xiayuan Liang, Christopher C. Silliman. (2011) A two-event in vitro model of acute chest syndrome: The role of secretory phospholipase A2 and neutrophils. Pediatric Blood & Cancern/a-n/a
CrossRef98
M.A. Bender, Katie R. Nielsen. 2011. Hemoglobinopathies. , 1191-1206.
CrossRef99
Carlos Gomez. 2010. Children, Maldynic Pain, and the Creation of Suffering. .
CrossRef100
K. L. Wallace, J. Linden. (2010) Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease. Blood 116:23, 5010-5020
CrossRef101
Vijay G. Sankaran, Guillaume Lettre, Stuart H. Orkin, Joel N. Hirschhorn. (2010) Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Annals of the New York Academy of Sciences 1214:1, 47-56
CrossRef102
David C Rees, Thomas N Williams, Mark T Gladwin. (2010) Sickle-cell disease. The Lancet 376:9757, 2018-2031
CrossRef103
Javid Gaziev, Guido Lucarelli. (2010) Allogeneic Cellular Gene Therapy for Hemoglobinopathies. Hematology/Oncology Clinics of North America 24:6, 1145-1163
CrossRef104
K. NSIAH, V. P. DZOGBEFIA, D. ANSONG, H. BOATENG, D. OCLOO, E. OSEI-FREMPONG, N. KENA FREMPONG, A. OSEI AKOTO. (2010) The incidence of malaria and the comparison of hematological and biochemical indices of Plasmodium falciparum-parasitemic and aparasitemic sickle cell disease (SCD) patients. International Journal of Laboratory Hematology 32:6p1, e197-e207
CrossRef105
George Atweh, Hassana Fathallah. (2010) Pharmacologic Induction of Fetal Hemoglobin Production. Hematology/Oncology Clinics of North America 24:6, 1131-1144
CrossRef106
C. Sangokoya, M. J. Telen, J.-T. Chi. (2010) microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood 116:20, 4338-4348
CrossRef107
Vlad Calin Radulescu, Jeffrey A. Moscow. (2010) Adult patients with childhood anemias. International Journal on Disability and Human Development 9:2-3, 217-223
CrossRef108
Oluseyi Oniyangi, Damian H Cohall, Oluseyi Oniyangi. 2010. Phytomedicines (medicines derived from plants) for sickle cell disease. .
CrossRef109
Xandra W. van den Tweel, Johanna H. van der Lee, Harriët Heijboer, Marjolein Peters, Karin Fijnvandraat. (2010) Development and validation of a pediatric severity index for sickle cell patients. American Journal of Hematology 85:10, 746-751
CrossRef110
Kevin Joseph Sullivan, Niranjan Kissoon, Eric Sandler, Cynthia Gauger, Melanie Froyen, Laurie Duckworth, Martha Brown, Suzanne Murphy. (2010) Effect of Oral Arginine Supplementation on Exhaled Nitric Oxide Concentration in Sickle Cell Anemia and Acute Chest Syndrome. Journal of Pediatric Hematology/Oncology 32:7, e249-e258
CrossRef111
Lamia P. Barakat, Lisa A. Schwartz, Katherine S. Salamon, Jerilynn Radcliffe. (2010) A Family-based Randomized Controlled Trial of Pain Intervention for Adolescents With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 32:7, 540-547
CrossRef112
Ruth Hüttenhain, Sonja Hess. (2010) A combined top-down and bottom-up MS approach for the characterization of hemoglobin variants in Rhesus monkeys. PROTEOMICS 10:20, 3657-3668
CrossRef113
J. Chen, K. R. Peterson, C. Iancu-Rubin, J. J. Bieker. (2010) Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo. Proceedings of the National Academy of Sciences 107:39, 16846-16851
CrossRef114
J. Chang, J. T. Patton, A. Sarkar, B. Ernst, J. L. Magnani, P. S. Frenette. (2010) GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood 116:10, 1779-1786
CrossRef115
Jack L. Bartram, Swee L. Thein, Kate Gardner, Yaya Egberongbe, Pam D’Silva, Susan E. Height, Moira C. Dick, Sandra O’Driscoll, David C. Rees. (2010) Outcome of children with sickle cell disease admitted to intensive care - a single institution experience. British Journal of Haematology 150:5, 614-617
CrossRef116
Kate Gardner, Cathy Bell, Jack L. Bartram, Marlene Allman, Moji Awogbade, David C. Rees, Max Ervine, Swee L. Thein. (2010) Outcome of adults with sickle cell disease admitted to critical care - experience of a single institution in the UK. British Journal of Haematology 150:5, 610-613
CrossRef117
Kenneth I. Ataga, Julia E. Brittain, Dominic Moore, Susan K. Jones, Ben Hulkower, Dell Strayhorn, Soheir Adam, Rupa Redding-Lallinger, Patrick Nachman, Eugene P. Orringer. (2010) Urinary albumin excretion is associated with pulmonary hypertension in sickle cell disease: potential role of soluble fms-like tyrosine kinase-1. European Journal of Haematology 85:3, 257-263
CrossRef118
Anna J. Battersby, Huxley H.M. Knox-Macaulay, Enitan D. Carrol. (2010) Susceptibility to invasive bacterial infections in children with sickle cell disease. Pediatric Blood & Cancer 55:3, 401-406
CrossRef119
Abiola Olowoyeye, Charles I Okwundu, Abiola Olowoyeye. 2010. Gene therapy for sickle cell disease. .
CrossRef120
Kiran Jawaid, Karin Wahlberg, Swee Lay Thein, Steve Best. (2010) Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus. Blood Cells, Molecules, and Diseases 45:2, 140-146
CrossRef121
V. Audard, S. Homs, A. Habibi, F. Galacteros, P. Bartolucci, B. Godeau, B. Renaud, Y. Levy, P. Grimbert, P. Lang, C. Brun-Buisson, L. Brochard, F. Schortgen, B. Maitre, A. Mekontso Dessap. (2010) Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertension. Nephrology Dialysis Transplantation 25:8, 2524-2529
CrossRef122
Danitza Nebor, Cédric Broquere, Karine Brudey, Danielle Mougenel, Vanessa Tarer, Philippe Connes, Jacques Elion, Marc Romana. (2010) Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients. Blood Cells, Molecules, and Diseases 45:2, 154-158
CrossRef123
Vijay G. Sankaran, Jian Xu, Stuart H. Orkin. (2010) Transcriptional silencing of fetal hemoglobin by BCL11A. Annals of the New York Academy of Sciences 1202:1, 64-68
CrossRef124
Muriel Fartoukh, Yannick Lefort, Anoosha Habibi, Dora Bachir, Frédéric Galacteros, Bertrand Godeau, Bernard Maitre, Laurent Brochard. (2010) Early intermittent noninvasive ventilation for acute chest syndrome in adults with sickle cell disease: a pilot study. Intensive Care Medicine 36:8, 1355-1362
CrossRef125
Paula Tanabe, Christopher Reddin, Victoria L. Thornton, Knox H. Todd, Ted Wun, John S. Lyons. (2010) Emergency Department Sickle Cell Assessment of Needs and Strengths (ED-SCANS), a Focus Group and Decision Support Tool Development Project. Academic Emergency Medicine 17:8, 848-858
CrossRef126
Maria Marsella, Alessia Pepe, Caterina Borgna-Pignatti. (2010) Better survival and less cardiac morbidity in female patients with thalassemia major: a review of the literature. Annals of the New York Academy of Sciences 1202:1, 129-133
CrossRef127
S. H. Orkin, D. R. Higgs. (2010) Sickle Cell Disease at 100 Years. Science 329:5989, 291-292
CrossRef128
M. C. Johnson, F. J. Kirkham, S. Redline, C. L. Rosen, Y. Yan, I. Roberts, J. Gruenwald, J. Marek, M. R. DeBaun. (2010) Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation. Blood 116:1, 16-21
CrossRef129
Soheir S. Adam, Marilyn J. Telen, Charles R. Jonassaint, Laura M. De Castro, Jude C. Jonassaint. (2010) The Relationship of Opioid Analgesia to Quality of Life in an Adult Sickle Cell Population. Health Outcomes Research in Medicine 1:1, e29-e37
CrossRef130
R. E. Ware. (2010) How I use hydroxyurea to treat young patients with sickle cell anemia. Blood 115:26, 5300-5311
CrossRef131
Danitza Nebor, Marie Claude Durpes, Danielle Mougenel, Martin Mukisi-Mukaza, Jacques Elion, Marie-Dominique Hardy-Dessources, Marc Romana. (2010) Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients. Clinical Immunology 136:1, 116-122
CrossRef132
Dennie T. Rogers, Robert Molokie. (2010) Sickle Cell Disease in Pregnancy. Obstetrics and Gynecology Clinics of North America 37:2, 223-237
CrossRef133
Amanda M Brandow, Julie A Panepinto. (2010) Hydroxyurea use in sickle cell disease: the battle with low prescription rates, poor patient compliance and fears of toxicities. Expert Review of Hematology 3:3, 255-260
CrossRef134
Ellen C. Ebert, Michael Nagar, Klaus D. Hagspiel. (2010) Gastrointestinal and Hepatic Complications of Sickle Cell Disease. Clinical Gastroenterology and Hepatology 8:6, 483-489
CrossRef135
R. T. Cohen, M. R. DeBaun, M. A. Blinder, R. C. Strunk, J. J. Field. (2010) Smoking is associated with an increased risk of acute chest syndrome and pain among adults with sickle cell disease. Blood 115:18, 3852-3854
CrossRef136
Meenakshi Ramakrishnan, Jennifer C Moïsi, Keith P Klugman, Jesus M Feris Iglesias, Lindsay R Grant, Mireille Mpoudi-Etame, Orin S Levine. (2010) Increased risk of invasive bacterial infections in African people with sickle-cell disease: a systematic review and meta-analysis. The Lancet Infectious Diseases 10:5, 329-337
CrossRef137
ARUNA JHA, MARIE L. SUAREZ, CAROL E. FERRANS, ROBERT MOLOKIE, YOUNG OK KIM, DIANA J. WILKIE. (2010) Cognitive Testing of PAINReportIt in Adult African Americans With Sickle Cell Disease. CIN: Computers, Informatics, Nursing 28:3, 141-150
CrossRef138
S Majumdar, Z Robertson, A Robinson, S Starnes, R Iyer, G Megason. (2010) Outcome of hematopoietic cell transplantation in children with sickle cell disease, a single center's experience. Bone Marrow Transplantation 45:5, 895-900
CrossRef139
Vijay G. Sankaran, Jian Xu, Stuart H. Orkin. (2010) Advances in the understanding of haemoglobin switching. British Journal of Haematology 149:2, 181-194
CrossRef140
Glenda M. Ninkovich, Sally K. Miller, Patricia T. Alpert. (2010) Sickle-cell anemia and pulmonary hypertension. Journal of the American Academy of Nurse Practitioners 22:4, 198-204
CrossRef141
Paula Tanabe, Nicole Artz, D. Mark Courtney, Zoran Martinovich, Kevin B. Weiss, Elena Zvirbulis, John W. Hafner. (2010) Adult Emergency Department Patients with Sickle Cell Pain Crisis: A Learning Collaborative Model to Improve Analgesic Management. Academic Emergency Medicine 17:4, 399-407
CrossRef142
Charlotte F. J. van Tuijn, Erfan Nur, Eduard J. van Beers, Hans L. Zaaijer, Bart J. Biemond. (2010) Acute chest syndrome in sickle cell disease due to the new influenza A (H1N1) virus infection. American Journal of Hematology 85:4, 303-304
CrossRef143
Hussain R. Yusuf, Hani K. Atrash, Scott D. Grosse, Christopher S. Parker, Althea M. Grant. (2010) Emergency Department Visits Made by Patients with Sickle Cell Disease. American Journal of Preventive Medicine 38:4, S536-S541
CrossRef144
Violanda Grigorescu, Mary J. Kleyn, Steven J. Korzeniewski, William I. Young, Wanda Whitten-Shurney. (2010) Newborn Screening Follow-Up Within the Lifespan Context. American Journal of Preventive Medicine 38:4, S522-S527
CrossRef145
Kathryn L. Hassell. (2010) Population Estimates of Sickle Cell Disease in the U.S.. American Journal of Preventive Medicine 38:4, S512-S521
CrossRef146
E. Voskaridou, D. Christoulas, A. Bilalis, E. Plata, K. Varvagiannis, G. Stamatopoulos, K. Sinopoulou, A. Balassopoulou, D. Loukopoulos, E. Terpos. (2010) The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). Blood 115:12, 2354-2363
CrossRef147
J. E. Brittain, B. Hulkower, S. K. Jones, D. Strayhorn, L. De Castro, M. J. Telen, E. P. Orringer, A. Hinderliter, K. I. Ataga. (2010) Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood 115:10, 2014-2020
CrossRef148
Mauro Nervi. (2010) Mechanisms, malfunctions and explanation in medicine. Biology & Philosophy 25:2, 215-228
CrossRef149
Matthew P. Lazio, Heather H. Costello, D. Mark Courtney, Zoran Martinovich, Randall Myers, Amy Zosel, Paula Tanabe. (2010) A Comparison of Analgesic Management for Emergency Department Patients With Sickle Cell Disease and Renal Colic. The Clinical Journal of Pain 26:3, 199-205
CrossRef150
Suba Krishnan, Yamaja Setty, Suhita G. Betal, Vaidyula Vijender, Koneti Rao, Carlton Dampier, Marie Stuart. (2010) Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises. British Journal of Haematology 148:5, 797-804
CrossRef151
Gavin Cho, Ian R Hambleton, Gavin Cho. 2010. Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease. .
CrossRef152
M. Wilson, P. Forsyth, J. Whiteside. (2010) Haemoglobinopathy and sickle cell disease. Continuing Education in Anaesthesia, Critical Care & Pain 10:1, 24-28
CrossRef153
Matthew M. Heeney, Russell E. Ware. (2010) Hydroxyurea for Children with Sickle Cell Disease. Hematology/Oncology Clinics of North America 24:1, 199-214
CrossRef154
Gwenola Maigne, Sophie Ferlicot, Frederic Galacteros, Xavier Belenfant, Tim Ulinski, Patrick Niaudet, Pierre Ronco, Bertrand Godeau, Antoine Durrbach, Sabrinel Sahali, Philippe Lang, Olivier Lambotte, Vincent Audard. (2010) Glomerular Lesions in Patients With Sickle Cell Disease. Medicine 89:1, 18-27
CrossRef155
Russell E. Ware, Renee C. Rees, Sharada A. Sarnaik, Rathi V. Iyer, Ofelia A. Alvarez, James F. Casella, Barry L. Shulkin, Eglal Shalaby-Rana, C. Frederic Strife, John H. Miller, Peter A. Lane, Winfred C. Wang, Scott T. Miller. (2010) Renal Function in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial. The Journal of Pediatrics 156:1, 66-70.e1
CrossRef156
Catherine Booth, Baba Inusa, Stephen K. Obaro. (2010) Infection in sickle cell disease: A review. International Journal of Infectious Diseases 14:1, e2-e12
CrossRef157
Amanda M. Brandow, David C. Brousseau, Nicholas M. Pajewski, Julie A. Panepinto. (2010) Vaso-occlusive painful events in sickle cell disease: Impact on child well-being. Pediatric Blood & Cancer 54:1, 92-97
CrossRef158
Martin H. Steinberg, Willian F. McCarthy, Oswaldo Castro, Samir K. Ballas, F. Danny Armstrong, Wally Smith, Kenneth Ataga, Paul Swerdlow, Abdullah Kutlar, Laura DeCastro, Myron A. Waclawiw, . (2010) The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. American Journal of HematologyNA-NA
CrossRef159
Hari Prabhakar, Carlton Haywood, Robert Molokie. (2010) Sickle cell disease in the United States: Looking back and forward at 100 years of progress in management and survival. American Journal of HematologyNA-NA
CrossRef160
Christoph Scheiermann, Yuya Kunisaki, Jung-Eun Jang, Paul S Frenette. (2010) Neutrophil microdomains: linking heterocellular interactions with vascular injury. Current Opinion in Hematology 17:1, 25-30
CrossRef161
James H. Garvin Jr. 2010. Gender-Specific Aspects of Pediatric Hematology and Oncology. , 51-61.
CrossRef162
Abboud, Miguel R., . (2009) Hematopoietic Stem-Cell Transplantation for Adults with Sickle Cell Disease. New England Journal of Medicine 361:24, 2380-2381
Full Text163
G. R. SERJEANT, B. E. SERJEANT, K. P. MASON, I. R. HAMBLETON, C. FISHER, D. R. HIGGS. (2009) The changing face of homozygous sickle cell disease: 102 patients over 60 years. International Journal of Laboratory Hematology 31:6, 585-596
CrossRef164
V. R. Gordeuk, A. Campbell, S. Rana, M. Nouraie, X. Niu, C. P. Minniti, C. Sable, D. Darbari, N. Dham, O. Onyekwere, T. Ammosova, S. Nekhai, G. J. Kato, M. T. Gladwin, O. L. Castro. (2009) Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood 114:21, 4639-4644
CrossRef165
P. Bartolucci, T. El Murr, F. Roudot-Thoraval, A. Habibi, A. Santin, B. Renaud, V. Noel, M. Michel, D. Bachir, F. Galacteros, B. Godeau. (2009) A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults. Blood 114:18, 3742-3747
CrossRef166
Janet Chin, Mahipal Singh, Virryan Banzon, Kestis Vaitkus, Vinzon Ibanez, Tatiana Kouznetsova, Nadim Mahmud, Joseph DeSimone, Donald Lavelle. (2009) Transcriptional activation of the γ-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms. Experimental Hematology 37:10, 1131-1142
CrossRef167
Vittorio Fineschi, Emanuela Turillazzi. 2009. Natural Causes of Sudden Death: Noncardiac. .
CrossRef168
Robert F Wynn, Jaap Jan Boelens. (2009) Bone-marrow transplantation in non-malignant disease. The Lancet 374:9693, 856-858
CrossRef169
John J. Strouse, Lori C. Jordan, Sophie Lanzkron, James F. Casella. (2009) The excess burden of stroke in hospitalized adults with sickle cell disease. American Journal of Hematology 84:9, 548-552
CrossRef170
A. Perumbeti, T. Higashimoto, F. Urbinati, R. Franco, H. J. Meiselman, D. Witte, P. Malik. (2009) A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction. Blood 114:6, 1174-1185
CrossRef171
K. Wahlberg, J. Jiang, H. Rooks, K. Jawaid, F. Matsuda, M. Yamaguchi, M. Lathrop, S. L. Thein, S. Best. (2009) The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells. Blood 114:6, 1254-1262
CrossRef172
Jo Howard, Veronica J Thomas, Heather M Rawle. (2009) Pain management and quality of life in sickle cell disease. Expert Review of Pharmacoeconomics & Outcomes Research 9:4, 347-352
CrossRef173
Mariane de Montalembert. (2009) Current strategies for the management of children with sickle cell disease. Expert Review of Hematology 2:4, 455-463
CrossRef174
K. L. Wallace, M. A. Marshall, S. I. Ramos, J. A. Lannigan, J. J. Field, R. M. Strieter, J. Linden. (2009) NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN- and CXCR3 chemokines. Blood 114:3, 667-676
CrossRef175
D. B. Bailey, F. D. Armstrong, A. R. Kemper, D. Skinner, S. F. Warren. (2009) Supporting Family Adaptation to Presymptomatic and "Untreatable" Conditions in an Era of Expanded Newborn Screening. Journal of Pediatric Psychology 34:6, 648-661
CrossRef176
G. R. Kirk, M. R. Haynes, S. Palasis, C. Brown, T. G. Burns, M. McCormick, R. A. Jones. (2009) Regionally Specific Cortical Thinning in Children with Sickle Cell Disease. Cerebral Cortex 19:7, 1549-1556
CrossRef177
Samir K. Ballas. (2009) The cost of health care for patients with sickle cell disease. American Journal of Hematology 84:6, 320-322
CrossRef178
Valerie Mann-Jiles, Diana Lynn Morris. (2009) Quality of life of adult patients with sickle cell disease. Journal of the American Academy of Nurse Practitioners 21:6, 340-349
CrossRef179
Teresa L. Kauf, Thomas D. Coates, Liu Huazhi, Nikita Mody-Patel, Abraham G. Hartzema. (2009) The cost of health care for children and adults with sickle cell disease. American Journal of Hematology 84:6, 323-327
CrossRef180
Omer Placide Dossou-Yovo, Isabelle Zaccaria, Malika Benkerrou, Michelle Hauchecorne, Corinne Alberti, Mohamed Chérif Rahimy, Jacques Elion, Claudine Lapoumeroulie. (2009) Effects of RANTES and MBL2 gene polymorphisms in sickle cell disease clinical outcomes: Association of the g.In1.1T>C RANTES variant with protection against infections. American Journal of Hematology 84:6, 378-380
CrossRef181
Paul G. Firth. (2009) Anesthesia and Hemoglobinopathies. Anesthesiology Clinics 27:2, 321-336
CrossRef182
Parameswaran Anoop, David H. Bevan, Suparno Chakrabarti. (2009) Usefulness and limitations of Bayesian network model as a mortality risk assessment tool in sickle cell anemia. American Journal of Hematology 84:5, 312-313
CrossRef183
Imoigele P. Aisiku, Wally R. Smith, Donna K. McClish, James L. Levenson, Lynne T. Penberthy, Susan D. Roseff, Viktor E. Bovbjerg, John D. Roberts. (2009) Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease. Annals of Emergency Medicine 53:5, 587-593
CrossRef184
Richard Payne. (2009) Sickle Cell Anemia and Pain: Will Data Prevail Over Beliefs?. Annals of Emergency Medicine 53:5, 596-597
CrossRef185
Jane Hankins, Banu Aygun. (2009) Pharmacotherapy in sickle cell disease - state of the art and future prospects. British Journal of Haematology 145:3, 296-308
CrossRef186
Swee Lay Thein, Stephan Menzel. (2009) Discovering the genetics underlying foetal haemoglobin production in adults. British Journal of Haematology 145:4, 455-467
CrossRef187
Michael B. Stone. (2009) Acute chest syndrome diagnosed by lung sonography. The American Journal of Emergency Medicine 27:4, 516.e5-516.e6
CrossRef188
Ardie Pack-Mabien, Johnson Haynes. (2009) A primary care provider’s guide to preventive and acute care management of adults and children with sickle cell disease. Journal of the American Academy of Nurse Practitioners 21:5, 250-257
CrossRef189
Araba Afenyi-Annan, Allison Ashley-Koch, Marilyn J. Telen. (2009) Duffy (Fy), DARC , and neutropenia among women from the United States, Europe and the Caribbean. British Journal of Haematology 145:2, 266-267
CrossRef190
Pasquale Niscola, Francesco Sorrentino, Laura Scaramucci, Paolo de Fabritiis, Paolo Cianciulli. (2009) Pain Syndromes in Sickle Cell Disease: An Update. Pain Medicine 10:3, 470-480
CrossRef191
N. Mahdi, A. M. Al-Subaie, K. Al-Ola, A. Q. Al-Irhayim, M. E. Ali, Z. Al-Irhayim, W. Y. Almawi. (2009) HLA DRB1*130101-DQB1*060101 haplotype is associated with acute chest syndrome in sickle cell anemia patients. Tissue Antigens 73:3, 245-249
CrossRef192
Jessica H. Boyd, Michael R. DeBaun, Wayne J. Morgan, Jingnan Mao, Robert C. Strunk. (2009) Lower airway obstruction is associated with increased morbidity in children with sickle cell disease. Pediatric Pulmonology 44:3, 290-296
CrossRef193
Camela S. McDougald, Christopher L. Edwards, Mary Wood, Chante Wellington, Miriam Feliu, Keisha O’Garo, Lekisha Edwards, Elwood Robinson, Keith E. Whitfield, Sherry Eaton, Kai Morgan, Goldie Byrd, John J. Sollers, Monique Cola, Cara F. O’Connell. (2009) Coping as Predictor of Psychiatric Functioning and Pain in Patients with Sickle Cell Disease (SCD). Journal of African American Studies 13:1, 47-62
CrossRef194
Jessica Knight-Perry, Michael R DeBaun, Robert C Strunk, Joshua J Field. (2009) Leukotriene pathway in sickle cell disease: a potential target for directed therapy. Expert Review of Hematology 2:1, 57-68
CrossRef195
Sara Trompeter, Irene Roberts. (2009) Haemoglobin F modulation in childhood sickle cell disease. British Journal of Haematology 144:3, 308-316
CrossRef196
Tamara I Pestina, Phillip W Hargrove, Dennis Jay, John T Gray, Kelli M Boyd, Derek A Persons. (2009) Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin. Molecular Therapy 17:2, 245-252
CrossRef197
Volker Schettler, Eberhard Wieland. (2009) A Case Report of Darbepoetin Treatment in a Patient With Sickle Cell Disease and Chronic Renal Failure Undergoing Regular Hemodialysis Procedures That Induce a Dose-Dependent Extension of Blood Transfusion Intervals. Therapeutic Apheresis and Dialysis 13:1, 80-82
CrossRef198
Abiola Olowoyeye, Charles I Okwundu, Abiola Olowoyeye. 2009. Gene therapy for sickle cell disease. .
CrossRef199
Chioma Oringanje, Eneida Nemecek, Oluseyi Oniyangi, Chioma Oringanje. 2009. Hematopoietic stem cell transplantation for children with sickle cell disease. .
CrossRef200
Amy Sobota, Dionne A. Graham, Matthew M. Heeney, Ellis J. Neufeld. (2009) Corticosteroids for acute chest syndrome in children with sickle cell disease: Variation in use and association with length of stay and readmission. American Journal of HematologyNA-NA
CrossRef201
K. I. Ataga. (2009) Novel therapies in sickle cell disease. Hematology 2009:1, 54-61
CrossRef202
Bruce W. Thompson, Scott T. Miller, Zora R. Rogers, Renee C. Rees, Russell E. Ware, Myron A. Waclawiw, Rathi V. Iyer, James F. Casella, Lori Luchtman-Jones, Sohail Rana, Courtney D. Thornburg, Ram V. Kalpatthi, Julio C. Barredo, R. Clark Brown, Sharada Sarnaik, Thomas H. Howard, Lori Luck, Winfred C. Wang. (2009) The pediatric hydroxyurea phase III clinical trial (BABY HUG): Challenges of study design. Pediatric Blood & Cancern/a-n/a
CrossRef203
R. E. Ware, B. Aygun. (2009) Advances in the use of hydroxyurea. Hematology 2009:1, 62-69
CrossRef204
M. Michel, A. Habibi, B. Godeau, D. Bachir, A. Lahary, F. Galacteros, A. Fifi-Mah, S. Arfi. (2008) Characteristics and Outcome of Connective Tissue Diseases in Patients with Sickle-Cell Disease: Report of 30 Cases. Seminars in Arthritis and Rheumatism 38:3, 228-240
CrossRef205
Gladwin, Mark T., Vichinsky, Elliott, . (2008) Pulmonary Complications of Sickle Cell Disease. New England Journal of Medicine 359:21, 2254-2265
Full Text206
Lakshmanan Krishnamurti, Sandhya Kharbanda, Melinda A. Biernacki, Wandi Zhang, K. Scott Baker, John E. Wagner, Catherine J. Wu. (2008) Stable Long-Term Donor Engraftment following Reduced-Intensity Hematopoietic Cell Transplantation for Sickle Cell Disease. Biology of Blood and Marrow Transplantation 14:11, 1270-1278
CrossRef207
R. Zennadi, A. Chien, K. Xu, M. Batchvarova, M. J. Telen. (2008) Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium. Blood 112:8, 3474-3483
CrossRef208
Megumi J. Okumura, Michele Heisler, Matthew M. Davis, Michael D. Cabana, Sonya Demonner, Eve A. Kerr. (2008) Comfort of General Internists and General Pediatricians in Providing Care for Young Adults with Chronic Illnesses of Childhood. Journal of General Internal Medicine 23:10, 1621-1627
CrossRef209
N. Patel, C. S. Gonsalves, M. Yang, P. Malik, V. K. Kalra. (2008) Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood 113:5, 1129-1138
CrossRef210
S. D. Nandedkar, T. R. Feroah, W. Hutchins, D. Weihrauch, K. S. Konduri, J. Wang, R. C. Strunk, M. R. DeBaun, C. A. Hillery, K. A. Pritchard. (2008) Histopathology of experimentally induced asthma in a murine model of sickle cell disease. Blood 112:6, 2529-2538
CrossRef211
Paul M. Armistead, Mehrdad Mohseni, Roslyn Gerwin, Emily C. Walsh, Masoud Iravani, Bahram Chahardouli, Shahrbano Rostami, Wandi Zhang, Donna Neuberg, John Rioux, Ardeshir Ghavamzadeh, Jerome Ritz, Joseph H. Antin, Catherine J. Wu. (2008) Erythroid-lineage–specific engraftment in patients with severe hemoglobinopathy following allogeneic hematopoietic stem cell transplantation. Experimental Hematology 36:9, 1205-1215
CrossRef212
Jean L. Raphael, Aditi Kamdar, Tao Wang, Hao Liu, Donald H. Mahoney, Brigitta U. Mueller. (2008) Day hospital versus inpatient management of uncomplicated vaso‐occlusive crises in children with sickle cell disease. Pediatric Blood & Cancer 51:3, 398-401
CrossRef213
Robert C. Strunk, Michael Scott Brown, Jessica H. Boyd, Pamela Bates, Joshua J. Field, Michael R. DeBaun. (2008) Methacholine challenge in children with sickle cell disease: A case series. Pediatric Pulmonology 43:9, 924-929
CrossRef214
Rodwell Mabaera, Rachel J. West, Sarah J. Conine, Elizabeth R. Macari, Chelsea D. Boyd, Cocav A. Engman, Christopher H. Lowrey. (2008) A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger. Experimental Hematology 36:9, 1057-1072
CrossRef215
Christopher A. Tormey, Edward L. Snyder, Dennis L. Cooper. (2008) Mobilization, collection, and transplantation of peripheral blood hematopoietic progenitor cells in a patient with multiple myeloma and hemoglobin SC disease. Transfusion 48:9, 1930-1933
CrossRef216
G. Lettre, V. G. Sankaran, M. A. C. Bezerra, A. S. Araujo, M. Uda, S. Sanna, A. Cao, D. Schlessinger, F. F. Costa, J. N. Hirschhorn, S. H. Orkin. (2008) From the Cover: DNA polymorphisms at the BCL11A, HBS1L-MYB, and -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proceedings of the National Academy of Sciences 105:33, 11869-11874
CrossRef217
Jamesetta A. Newland. (2008) Factors Influencing Independence in Adolescents With Sickle Cell Disease. Journal of Child and Adolescent Psychiatric Nursing 21:3, 177-185
CrossRef218
Coretta M. Jenerette, Carolyn Murdaugh. (2008) Testing the theory of self‐care management for sickle cell disease. Research in Nursing & Health 31:4, 355-369
CrossRef219
Raymond L. Benza. (2008) Pulmonary Hypertension Associated with Sickle Cell Disease: Pathophysiology and Rationale for Treatment. Lung 186:4, 247-254
CrossRef220
Ana G. Almeida, Francisco Arajo, Fernanda Rego, Cludio David, Mrio G. Lopes, J. Ducla-Soares. (2008) Abnormal Myocardial Flow Reserve in Sickle Cell Disease: A Myocardial Contrast Echocardiography Study. Echocardiography 25:6, 591-599
CrossRef221
Arun S. Shet, Thomas J. Hoffmann, Marketa Jirouskova, Christin A. Janczak, Jacqueline R.M. Stevens, Adewole Adamson, Narla Mohandas, Elizabeth A. Manci, Therese Cynober, Barry S. Coller. (2008) Morphological and functional platelet abnormalities in Berkeley sickle cell mice. Blood Cells, Molecules, and Diseases 41:1, 109-118
CrossRef222
Joshua J. Field, Jeffrey Glassberg, Annette Gilmore, Joanna Howard, Sameer Patankar, Yan Yan, Sally C. Davies, Michael R. DeBaun, Robert C. Strunk. (2008) Longitudinal analysis of pulmonary function in adults with sickle cell disease. American Journal of Hematology 83:7, 574-576
CrossRef223
Jean L. Raphael, Aditi Kamdar, M. Brooke Beavers, Donald H. Mahoney, Brigitta U. Mueller. (2008) Treatment of uncomplicated vaso-occlusive crises in children with sickle cell disease in a day hospital. Pediatric Blood & Cancer 51:1, 82-85
CrossRef224
Elizabeth S. Klings, Demedrick Anton Bland, Dara Rosenman, Stephanie Princeton, Adam Odhiambo, Guihua Li, Sheilah A. Bernard, Martin H. Steinberg, Harrison W. Farber. (2008) Pulmonary arterial hypertension and left‐sided heart disease in sickle cell disease: Clinical characteristics and association with soluble adhesion molecule expression. American Journal of Hematology 83:7, 547-553
CrossRef225
A. E. Ashley-Koch, L. Elliott, M. E. Kail, L. M. De Castro, J. Jonassaint, T. L. Jackson, J. Price, K. I. Ataga, M. C. Levesque, J. B. Weinberg, E. P. Orringer, A. Collins, J. M. Vance, M. J. Telen. (2008) Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood 111:12, 5721-5726
CrossRef226
F. M. J. Harban, P. Connor, R. Crook, R. Bingham. (2008) Cardiopulmonary bypass for surgical correction of congenital heart disease in children with sickle cell disease: a case series. Anaesthesia 63:6, 648-651
CrossRef227
Zakari Y. Aliyu, Victor Gordeuk, Vandana Sachdev, Aliyu Babadoko, Aisha I. Mamman, Peter Akpanpe, Ester Attah, Yusuf Suleiman, Nurudeen Aliyu, Jamilu Yusuf, Laurel Mendelsohn, Gregory J. Kato, Mark T. Gladwin. (2008) Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria. American Journal of Hematology 83:6, 485-490
CrossRef228
A.E. Fawibe. (2008) Managing acute chest syndrome of sickle cell disease in an African setting. Transactions of the Royal Society of Tropical Medicine and Hygiene 102:6, 526-531
CrossRef229
Justin Hering, Stefano Schena, Barney Dillard, James Doherty, Don Fishman, Steven Salzman. (2008) Acute chest syndrome following blunt liver laceration. Injury Extra 39:6, 216-218
CrossRef230
J Howard, V J Thomas, H Rawle, R Cartwright, N Westerdale. (2008) Quality of life and pain management in sickle-cell disease. Pediatric Health 2:3, 377-391
CrossRef231
Jason B Caboot, Julian L Allen. (2008) Pulmonary complications of sickle cell disease in children. Current Opinion in Pediatrics 20:3, 279-287
CrossRef232
Andrea Biondani, Franco Turrini, Franco Carta, Alessandro Matté, Alida Filippini, Angela Siciliano, Yves Beuzard, Lucia De Franceschi. (2008) Heat-shock protein-27, -70 and peroxiredoxin–II show molecular chaperone function in sickle red cells: Evidence from transgenic sickle cell mouse model. PROTEOMICS – CLINICAL APPLICATIONS 2:5, 706-719
CrossRef233
S Sangkatumvong, T D Coates, M C K Khoo. (2008) Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia. Physiological Measurement 29:5, 655-668
CrossRef234
John J. Strouse, Clifford M. Takemoto, Jeffrey R. Keefer, Gregory J. Kato, James F. Casella. (2008) Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. Pediatric Blood & Cancer 50:5, 1006-1012
CrossRef235
Nathalie Sabaa, Lucia de Franceschi, Philippe Bonnin, Yves Castier, Giorgio Malpeli, Haythem Debbabi, Ariane Galaup, Micheline Maier-Redelsperger, Sophie Vandermeersch, Aldo Scarpa, Anne Janin, Bernard Levy, Robert Girot, Yves Beuzard, Christophe Leboeuf, Annie Henri, Stéphane Germain, Jean-Claude Dussaule, Pierre-Louis Tharaux. (2008) Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease. Journal of Clinical Investigation 118:5, 1924-1933
CrossRef236
Swee Lay Thein. (2008) Genetic modifiers of the β-haemoglobinopathies. British Journal of Haematology 141:3, 357-366
CrossRef237
Julien Camous, Aya N’da, Maryse Etienne-Julan, François Stéphan. (2008) Anesthetic management of pregnant women with sickle cell disease — effect on postnatal sickling complications. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 55:5, 276-283
CrossRef238
Araba Afenyi-Annan, Melanie Kail, Martha R. Combs, Eugene P. Orringer, Allison Ashley-Koch, Marilyn J. Telen. (2008) Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. Transfusion 48:5, 917-924
CrossRef239
Kam Ki Tang, Jackie T.C. Chin, D.S. Prasada Rao. (2008) Avoidable mortality risks and measurement of wellbeing and inequality. Journal of Health Economics 27:3, 624-641
CrossRef240
Katherine C. Wood, Lewis L. Hsu, Mark T. Gladwin. (2008) Sickle cell disease vasculopathy: A state of nitric oxide resistance. Free Radical Biology and Medicine 44:8, 1506-1528
CrossRef241
Eliza F. Chakravarty, Dinesh Khanna, Lorinda Chung. (2008) Pregnancy Outcomes in Systemic Sclerosis, Primary Pulmonary Hypertension, and Sickle Cell Disease. Obstetrics & Gynecology 111:4, 927-934
CrossRef242
Matthew M. Heeney, Russell E. Ware. (2008) Hydroxyurea for Children with Sickle Cell Disease. Pediatric Clinics of North America 55:2, 483-501
CrossRef243
Platt, Orah S., . (2008) Hydroxyurea for the Treatment of Sickle Cell Anemia. New England Journal of Medicine 358:13, 1362-1369
Full Text244
Ward Hagar, Elliott Vichinsky. (2008) Advances in clinical research in sickle cell disease. British Journal of Haematology 0:0, 080313115903451-???
CrossRef245
Trudie Goers, Julie Panepinto, Michael DeBaun, Morey Blinder, Robert Foglia, Keith T. Oldham, Joshua J. Field. (2008) Laparoscopic versus open abdominal surgery in children with sickle cell disease is associated with a shorter hospital stay. Pediatric Blood & Cancer 50:3, 603-606
CrossRef246
Keydra L. Phillips, Ping An, Jessica H. Boyd, Robert C. Strunk, James F. Casella, Bruce A. Barton, Michael R. Debaun. (2008) Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma. American Journal of Human Biology 20:2, 149-153
CrossRef247
Paola Sebastiani, Ling Wang, Vikki G. Nolan, Efthymia Melista, Qianli Ma, Clinton T. Baldwin, Martin H. Steinberg. (2008) Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. American Journal of Hematology 83:3, 189-195
CrossRef248
Deepika S. Darbari, Caterina P. Minniti, Sohail Rana, John van den Anker. (2008) Pharmacogenetics of morphine: Potential implications in sickle cell disease. American Journal of Hematology 83:3, 233-236
CrossRef249
O. C. Onyekwere, A. Campbell, M. Teshome, S. Onyeagoro, C. Sylvan, A. Akintilo, S. Hutchinson, G. Ensing, P. Gaskin, G. Kato, S. Rana, J. Kwagyan, V. Gordeuk, J. Williams, O. Castro. (2008) Pulmonary Hypertension in Children and Adolescents with Sickle Cell Disease. Pediatric Cardiology 29:2, 309-312
CrossRef250
Fernando O. Pinto, Irene Roberts. (2008) Cord blood stem cell transplantation for haemoglobinopathies. British Journal of Haematology 0:0, 080226145103436-???
CrossRef251
M. Uda, R. Galanello, S. Sanna, G. Lettre, V. G. Sankaran, W. Chen, G. Usala, F. Busonero, A. Maschio, G. Albai, M. G. Piras, N. Sestu, S. Lai, M. Dei, A. Mulas, L. Crisponi, S. Naitza, I. Asunis, M. Deiana, R. Nagaraja, L. Perseu, S. Satta, M. D. Cipollina, C. Sollaino, P. Moi, J. N. Hirschhorn, S. H. Orkin, G. R. Abecasis, D. Schlessinger, A. Cao. (2008) Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of -thalassemia. Proceedings of the National Academy of Sciences 105:5, 1620-1625
CrossRef252
C. B. McClellan, J. Schatz, C. Sanchez, C. W. Roberts. (2008) Validity of the Pediatric Quality of Life Inventory for Youth with Sickle Cell Disease. Journal of Pediatric Psychology 33:10, 1153-1162
CrossRef253
Dawn Smiley, Samuel Dagogo-Jack, Guillermo Umpierrez. (2008) Therapy Insight: metabolic and endocrine disorders in sickle cell disease. Nature Clinical Practice Endocrinology & Metabolism 4:2, 102-109
CrossRef254
Anastassios C. Koumbourlis, Donna J. Lee, Ada Lee. (2008) Lung function and somatic growth in patients with hemoglobin SC sickle cell disease. Pediatric Pulmonology 43:2, 175-178
CrossRef255
Patrick Hines, George J. Dover, Linda M.S. Resar. (2008) Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia. Pediatric Blood & Cancer 50:2, 357-359
CrossRef256
Melissa J. Frei-Jones, Amy L. Baxter, Zora R. Rogers, George R. Buchanan. (2008) Vaso-Occlusive Episodes in Older Children with Sickle Cell Disease: Emergency Department Management and Pain Assessment. The Journal of Pediatrics 152:2, 281-285
CrossRef257
C Oringanje, E Nemecek, O Oniyangi, Chioma Oringanje. 2008. Hematopoietic stem cell transplantation for children with sickle cell disease. .
CrossRef258
B. N. Y. Setty, S. G. Betal. (2008) Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes. Blood 111:2, 905-914
CrossRef259
C. T. Quinn, N. J. Lee, E. P. Shull, N. Ahmad, Z. R. Rogers, G. R. Buchanan. (2008) Prediction of adverse outcomes in children with sickle cell anemia: a study of the Dallas Newborn Cohort. Blood 111:2, 544-548
CrossRef260
Laure A. Moutouh-de Parseval, Dominique Verhelle, Emilia Glezer, Kristen Jensen-Pergakes, Gregory D. Ferguson, Laura G. Corral, Christopher L. Morris, George Muller, Helen Brady, Kyle Chan. (2008) Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells. Journal of Clinical Investigation 118:1, 248-258
CrossRef261
Laura M. De Castro, Jude C. Jonassaint, Felicia L. Graham, Allison Ashley-Koch, Marilyn J. Telen. (2008) Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes. American Journal of Hematology 83:1, 19-25
CrossRef262
Eufemia Jacob, Brigitta U. Mueller. (2008) Pain Experience of Children with Sickle Cell Disease Who Had Prolonged Hospitalizations for Acute Painful Episodes. Pain Medicine 9:1, 13-21
CrossRef263
Sadhna M. Shankar, Patrick G. Arbogast, Ed Mitchel, Hua Ding, Winfred C. Wang, Marie R. Griffin. (2008) Impact of proximity to comprehensive sickle cell center on utilization of healthcare services among children with sickle cell disease. Pediatric Blood & Cancer 50:1, 66-71
CrossRef264
James G. Taylor, Diana Ackah, Crystal Cobb, Nick Orr, Melanie J. Percy, Vandana Sachdev, Roberto Machado, Oswaldo Castro, Gregory J. Kato, Stephen J. Chanock, Mark T. Gladwin. (2008) Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease. American Journal of Hematology 83:1, 6-14
CrossRef265
Lakshmanan Krishnamurti, H. Franklin Bunn, Andrea M. Williams, Jakub Tolar. (2008) Hematopoietic Cell Transplantation for Hemoglobinopathies. Current Problems in Pediatric and Adolescent Health Care 38:1, 6-18
CrossRef266
L. Benjamin. (2008) Pain Management in Sickle Cell Disease: Palliative Care Begins at Birth?. Hematology 2008:1, 466-474
CrossRef267
Zakari Y. Aliyu, Gregory J. Kato, James Taylor, Aliyu Babadoko, Aisha I. Mamman, Victor R. Gordeuk, Mark T. Gladwin. (2008) Sickle cell disease and pulmonary hypertension in Africa: A global perspective and review of epidemiology, pathophysiology, and management. American Journal of Hematology 83:1, 63-70
CrossRef268
Miguel R. Abboud, Ellen C. Taylor, David Habib, Terrie Dantzler-Johnson, Sherron M. Jackson, Fushen Xu, Joseph Laver, Samir K. Ballas. (2008) Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. British Journal of Haematology 111:2, 482
CrossRef269
Mutay Aslan, Bruce A. Freeman. (2007) Redox-dependent impairment of vascular function in sickle cell disease. Free Radical Biology and Medicine 43:11, 1469-1483
CrossRef270
Philip A. Berry, Timothy J.S. Cross, Swee Lay Thein, Bernard C. Portmann, Julia A. Wendon, John B. Karani, Michael A. Heneghan, Adrian Bomford. (2007) Hepatic Dysfunction in Sickle Cell Disease: A New System of Classification Based on Global Assessment. Clinical Gastroenterology and Hepatology 5:12, 1469-1476
CrossRef271
Mitchell E. Horwitz, Ivan Spasojevic, Ashley Morris, Marilyn Telen, James Essell, Cristina Gasparetto, Keith Sullivan, Gwynn Long, John Chute, Nelson Chao, David Rizzieri. (2007) Fludarabine-Based Nonmyeloablative Stem Cell Transplantation for Sickle Cell Disease with and without Renal Failure: Clinical Outcome and Pharmacokinetics. Biology of Blood and Marrow Transplantation 13:12, 1422-1426
CrossRef272
A. INATI, O. JRADI, H. TARABAY, H. MOALLEM, Y. RACHKIDI, R. EL ACCAOUI, H. ISMA’EEL, R. WEHBE, B. G. MFARREJ, I. DABBOUS, A. TAHER. (2007) Sickle cell disease: the Lebanese experience. International Journal of Laboratory Hematology 29:6, 399-408
CrossRef273
Q Ma, D F Wyszynski, J J Farrell, A Kutlar, L A Farrer, C T Baldwin, M H Steinberg. (2007) Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea. The Pharmacogenomics Journal 7:6, 386-394
CrossRef274
Jean L. Raphael, Krystal Harvey, Kent Stobart. (2007) The Cochrane Library and sickle cell disease: an overview of reviews. Evidence-Based Child Health: A Cochrane Review Journal 2:4, 1094-1101
CrossRef275
Madeleine Becker, David J. Axelrod, Olu Oyesanmi, Dimitri D. Markov, Elisabeth J. Shakin Kunkel. (2007) Hematologic Problems in Psychosomatic Medicine. Psychiatric Clinics of North America 30:4, 739-759
CrossRef276
S Shenoy. (2007) Has stem cell transplantation come of age in the treatment of sickle cell disease?. Bone Marrow Transplantation 40:9, 813-821
CrossRef277
Araba Afenyi-Annan, Monte S. Willis, Thomas R. Konrad, Richard Lottenberg. (2007) Blood bank management of sickle cell patients at comprehensive sickle cell centers. Transfusion 47:11, 2089-2097
CrossRef278
Eduard J. van Beers, Charlotte F.J. van Tuijn, Pythia T. Nieuwkerk, Philip W. Friederich, Jan H. Vranken, Bart J. Biemond. (2007) Patient-controlled analgesia versus continuous infusion of morphine during vaso-occlusive crisis in sickle cell disease, a randomized controlled trial. American Journal of Hematology 82:11, 955-960
CrossRef279
Andreia A. Canalli, Carla F. Franco-Penteado, Fabiola Traina, Sara T.O. Saad, Fernando F. Costa, Nicola Conran. (2007) Role for cAMP-protein kinase A signalling in augmented neutrophil adhesion and chemotaxis in sickle cell disease. European Journal of Haematology 79:4, 330-337
CrossRef280
Peter G. Vekilov. (2007) Sickle-cell haemoglobin polymerization: is it the primary pathogenic event of sickle-cell anaemia?. British Journal of Haematology 139:2, 173-184
CrossRef281
Tom V. Adamkiewicz, Paul Szabolcs, Ann Haight, K. Scott Baker, Susan Staba, Amos Kedar, K. Y. Chiang, Lakshmanan Krishnamurti, Michael W. Boyer, Joan Kurtzberg, John E. Wagner, John R. Wingard, Andrew M. Yeager. (2007) Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience. Pediatric Transplantation 11:6, 641-644
CrossRef282
C Hirst, S Owusu-Ofori. (2007) Cochrane review: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. Evidence-Based Child Health: A Cochrane Review Journal 2:3, 993-1009
CrossRef283
Jean L. Raphael, Brigitta U. Mueller. (2007) Commentary on ‘Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease’. Evidence-Based Child Health: A Cochrane Review Journal 2:3, 1012-1013
CrossRef284
D. R. Leff, T. Kaura, T. Agarwal, S. C. Davies, J. Howard, A. C. Chang. (2007) A nontransfusional perioperative management regimen for patients with sickle cell disease undergoing laparoscopic cholecystectomy. Surgical Endoscopy 21:7, 1117-1121
CrossRef285
S. L. Thein, S. Menzel, X. Peng, S. Best, J. Jiang, J. Close, N. Silver, A. Gerovasilli, C. Ping, M. Yamaguchi, K. Wahlberg, P. Ulug, T. D. Spector, C. Garner, F. Matsuda, M. Farrall, M. Lathrop. (2007) Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proceedings of the National Academy of Sciences 104:27, 11346-11351
CrossRef286
Jason K. Graham, Marina Mosunjac, Randy L. Hanzlick, Mario Mosunjac. (2007) Sickle Cell Lung Disease and Sudden Death. The American Journal of Forensic Medicine and Pathology 28:2, 168-172
CrossRef287
David C. Brousseau, D. Gail McCarver, Amy L. Drendel, Karthika Divakaran, Julie A. Panepinto. (2007) The Effect of CYP2D6 Polymorphisms on the Response to Pain Treatment for Pediatric Sickle Cell Pain Crisis. The Journal of Pediatrics 150:6, 623-626
CrossRef288
Julie A. Panepinto, Mark C. Walters, Jeanette Carreras, Judith Marsh, Christopher N. Bredeson, Robert Peter Gale, Gregory A. Hale, John Horan, Jill M. Hows, John P. Klein, Ricardo Pasquini, Irene Roberts, Keith Sullivan, Mary Eapen, Alina Ferster, . (2007) Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. British Journal of Haematology 137:5, 479-485
CrossRef289
Osamu Tanabe, David McPhee, Shoko Kobayashi, Yannan Shen, William Brandt, Xia Jiang, Andrew D Campbell, Yei-Tsung Chen, Chawn shang Chang, Masayuki Yamamoto, Keiji Tanimoto, James Douglas Engel. (2007) Embryonic and fetal β-globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal 26:9, 2295-2306
CrossRef290
Sunday T. C. Ilechukwu. (2007) Ogbanje / abiku and cultural conceptualizations of psychopathology in Nigeria. Mental Health, Religion & Culture 10:3, 239-255
CrossRef291
Paula Tanabe, Randall Myers, Amy Zosel, Jane Brice, Altaf H. Ansari, Julia Evans, Zoran Martinovich, Knox H. Todd, Judith A. Paice. (2007) Emergency Department Management of Acute Pain Episodes in Sickle Cell Disease. Academic Emergency Medicine 14:5, 419-425
CrossRef292
Stephen C. Nelson, Beverly B. Adade, Elizabeth A. McDonough, Kristin L. Moquist, Jane M. Hennessy. (2007) High Prevalence of Pulmonary Hypertension in Children With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 29:5, 334-337
CrossRef293
Arturo J Martí-Carvajal, Lucieni O Conterno, Jennifer M Knight-Madden, Arturo J Martí-Carvajal. 2007. Antibiotics for treating acute chest syndrome in people with sickle cell disease. .
CrossRef294
Anu Manchikanti Gomez, David A Grimes, Laureen M Lopez, Kenneth F Schulz, Anu Manchikanti Gomez. 2007. Steroid hormones for contraception in women with sickle cell disease. .
CrossRef295
Paul S. Frenette, George F. Atweh. (2007) Sickle cell disease: old discoveries, new concepts, and future promise. Journal of Clinical Investigation 117:4, 850-858
CrossRef296
Eileen M. Finnegan, Aslihan Turhan, David E. Golan, Gilda A. Barabino. (2007) Adherent leukocytes capture sickle erythrocytes in an in vitro flow model of vaso-occlusion. American Journal of Hematology 82:4, 266-275
CrossRef297
Tami D. Benton, Judith A. Ifeagwu, Kim Smith-Whitley. (2007) Anxiety and depression in children and adolescents with sickle cell disease. Current Psychiatry Reports 9:2, 114-121
CrossRef298
S Chakrabarti, D Bareford. (2007) A survey on patient perception of reduced-intensity transplantation in adults with sickle cell disease. Bone Marrow Transplantation 39:8, 447-451
CrossRef299
Laurie Duckworth, Lewis Hsu, Hua Feng, Jianwei Wang, James E. Sylvester, Niranjan Kissoon, Eric Sandler, John J. Lima. (2007) Physician-diagnosed asthma and acute chest syndrome: Associations with NOS Polymorphisms. Pediatric Pulmonology 42:4, 332-338
CrossRef300
Cassandra D. Josephson, Leon L. Su, Krista L. Hillyer, Christopher D. Hillyer. (2007) Transfusion in the Patient With Sickle Cell Disease: A Critical Review of the Literature and Transfusion Guidelines. Transfusion Medicine Reviews 21:2, 118-133
CrossRef301
Vikki G. Nolan, Qianli Ma, Herbert T. Cohen, Adeboye Adewoye, Anne C. Rybicki, Clinton Baldwin, Rhea N. Mahabir, Erica P. Homan, Diego F. Wyszynski, Mary E. Fabry, Ronald L. Nagel, Lindsay A. Farrer, Martin H. Steinberg. (2007) Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. American Journal of Hematology 82:3, 179-184
CrossRef302
Karl P. Sylvester, Richard A. Patey, Gerrard F. Rafferty, David Rees, Swee Lay Thein, Anne Greenough. (2007) Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. Pediatric Pulmonology 42:3, 272-276
CrossRef303
Nicola Conran, Sara T. O. Saad, Fernando F. Costa, Tohru Ikuta. (2007) Leukocyte numbers correlate with plasma levels of granulocyte–macrophage colony-stimulating factor in sickle cell disease. Annals of Hematology 86:4, 255-261
CrossRef304
Jean M. Tchuenche. (2007) Theoretical Population Dynamics Model of a Genetically Transmitted Disease: Sickle-Cell Anaemia. Bulletin of Mathematical Biology 69:2, 699-730
CrossRef305
Serjeant, Graham R., , Higgs, Douglas R., , Hambleton, Ian R., . (2007) Elderly Survivors with Homozygous Sickle Cell Disease. New England Journal of Medicine 356:6, 642-643
Full Text306
Lakshmanan Krishnamurti. (2007) Hematopoietic cell transplantation for sickle cell disease: state of the art. Expert Opinion on Biological Therapy 7:2, 161-172
CrossRef307
Arturo J Martí-Carvajal, Ivan Solà, Arturo J Martí-Carvajal. 2007. Treatment for anemia in people with AIDS. .
CrossRef308
M. R. DeBaun, J. J. Field. (2007) Limitations of Clinical Trials in Sickle Cell Disease: A Case Study of the Multi-center Study of Hydroxyurea (MSH) Trial and the Stroke Prevention (STOP) Trial. Hematology 2007:1, 482-488
CrossRef309
J. Makani, T. N. Williams, K. Marsh. (2007) Sickle cell disease in Africa: burden and research priorities. Annals of Tropical Medicine and Parasitology 101:1, 3-14
CrossRef310
Judith Tedlie Moskowitz, Ellen Butensky, Paul Harmatz, Elliott Vichinsky, Melvin B. Heyman, Michael Acree, Judith Wrubel, Leslie Wilson, Susan Folkman. (2007) Caregiving time in sickle cell disease: Psychological effects in maternal caregivers. Pediatric Blood & Cancer 48:1, 64-71
CrossRef311
Luanne L. Peters, Raymond F. Robledo, Carol J. Bult, Gary A. Churchill, Beverly J. Paigen, Karen L. Svenson. (2007) The mouse as a model for human biology: a resource guide for complex trait analysis. Nature Reviews Genetics 8:1, 58-69
CrossRef312
Dany Elsayegh, Janet M. Shapiro. (2007) Sickle Cell Vasoocclusive Crisis and Acute Chest Syndrome at Term Pregnancy. Southern Medical Journal 100:1, 77-79
CrossRef313
Roberto F. Machado, A. Kyle Mack, Sabrina Martyr, Christopher Barnett, Peter MacArthur, Vandana Sachdev, Inez Ernst, Lori A. Hunter, Wynona A. Coles, James P. Nichols, Gregory J. Kato, Mark T. Gladwin. (2007) Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease. British Journal of Haematology 136:2, 319-325
CrossRef314
Vandana Sachdev, Roberto F. Machado, Yukitaka Shizukuda, Yesoda N. Rao, Stanislav Sidenko, Inez Ernst, Marilyn St. Peter, Wynona A. Coles, Douglas R. Rosing, William C. Blackwelder, Oswaldo Castro, Gregory J. Kato, Mark T. Gladwin. (2007) Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients With Sickle Cell Disease. Journal of the American College of Cardiology 49:4, 472-479
CrossRef315
Kenneth Ataga, Richard Lottenberg. 2007. Hemostatic Aspects of Sickle Cell Disease. , 723-735.
CrossRef316
Steven J. Ambrusko, Sriya Gunawardena, Allison Sakara, Beth Windsor, Lizabeth Lanford, Peter Michelson, Lakshmanan Krishnamurti. (2006) Elevation of tricuspid regurgitant jet velocity, a marker for pulmonary hypertension in children with sickle cell disease. Pediatric Blood & Cancer 47:7, 907-913
CrossRef317
Fabiana B. Barros, Carmen S.P. Lima, Allan O. Santos, Mariana F.C. Mazo-Ruiz, Mariana C.L. Lima, Elba C.S.C. Etchebehere, Fernando F. Costa, Sara T.O. Saad, Edwaldo E. Camargo, Celso D. Ramos. (2006) 51Cr-EDTA measurements of the glomerular filtration rate in patients with sickle cell anaemia and minor renal damage. Nuclear Medicine Communications 27:12, 959-962
CrossRef318
A.K. Njamnshi, E.N. Mbong, A. Wonkam, P. Ongolo-Zogo, V.-de-P. Djientcheu, F.L. Sunjoh, C.S. Wiysonge, R. Sztajzel, D. Mbanya, K. Ngu Blackett, L. Dongmo, W.F.T. Muna. (2006) The epidemiology of stroke in sickle cell patients in Yaounde, Cameroon. Journal of the Neurological Sciences 250:1-2, 79-84
CrossRef319
Jean M. Tchuenche ., Wuraola A. Shokunbi .. (2006) Survival Probability of Sickle Cell Patients with Respect to HbF Levels. Journal of Applied Sciences 6:13, 2804-2808
CrossRef320
Melissa Mazur, Joanne Kurtzberg, Edward Halperin, Gilbert Ciocci, Paul Szabolcs. (2006) Transplantation of a Child With Sickle Cell Anemia With an Unrelated Cord Blood Unit After Reduced Intensity Conditioning. Journal of Pediatric Hematology/Oncology 28:12, 840-844
CrossRef321
N Qureshi, B Lubin, M C Walters. (2006) The prevention and management of stroke in sickle cell anaemia. Expert Opinion on Biological Therapy 6:11, 1087-1098
CrossRef322
R. Dickerhoff. (2006) Sichelzellkrankheit in Deutschland. Monatsschrift Kinderheilkunde 154:11, 1081-1089
CrossRef323
Deepika S. Darbari, Paul Kple-Faget, John Kwagyan, Sohail Rana, Victor R. Gordeuk, Oswaldo Castro. (2006) Circumstances of death in adult sickle cell disease patients. American Journal of Hematology 81:11, 858-863
CrossRef324
Oluseyi Oniyangi, Aika AA Omari, Oluseyi Oniyangi. 2006. Malaria chemoprophylaxis in sickle cell disease. .
CrossRef325
A Manchikanti, DA Grimes, LM Lopez, KF Schulz, Anu Manchikanti. 2006. Steroid hormones for contraception in women with sickle cell disease. .
CrossRef326
Lalita Chulamokha, Stephen J. Scholand, Jeff M. Riggio, Samir K. Ballas, David Horn, Joseph A. DeSimone. (2006) Bloodstream infections in hospitalized adults with sickle cell disease: A retrospective analysis. American Journal of Hematology 81:10, 723-728
CrossRef327
K. S. CHARLES, K. OSAGIE, R. K. BATTINI. (2006) Hospital admissions for acute painful crisis in Trinidad and Tobago. Are the British Committee for Standards in Haematology (BCSH) guidelines applicable?. Clinical and Laboratory Haematology 28:5, 299-302
CrossRef328
Pornpatr Ausavarungnirun, Hernan Sabio, Jongyeol Kim, Charles H. Tegeler. (2006) Dynamic Vascular Analysis Shows a Hyperemic Flow Pattern in Sickle Cell Disease. Journal of Neuroimaging 16:4, 311-317
CrossRef329
Casey W. Melton, Johnson Haynes. (2006) Sickle Acute Lung Injury: Role of Prevention and Early Aggressive Intervention Strategies on Outcome. Clinics in Chest Medicine 27:3, 487-502
CrossRef330
Vincent Audard, Philippe Grimbert, Matthias Kirsch, M. Anoosha Habibi, Philippe Lang, Philippe Remy, Claude Abbou, Daniel Loisance, Nicole Benaiem, Dora Bachir, Emmanuelle Vermes. (2006) Successful Combined Heart and Kidney Transplantation in a Patient With Sickle-cell Anemia. The Journal of Heart and Lung Transplantation 25:8, 993-996
CrossRef331
Jeffrey Glassberg, John F. Spivey, Robert Strunk, Sara Boslaugh, Michael R. DeBaun. (2006) Painful Episodes in Children With Sickle Cell Disease and Asthma are Temporally Associated With Respiratory Symptoms. Journal of Pediatric Hematology/Oncology 28:8, 481-485
CrossRef332
AJ Martí-Carvajal, LO Conterno, JM Knight-Madden, Arturo Martí-Carvajal. 2006. Antibiotics for treating acute chest syndrome in people with sickle cell disease. .
CrossRef333
Arturo J Martí-Carvajal, Lucieni O Conterno, Arturo J Martí-Carvajal. 2006. Antibiotics for treating community acquired pneumonia in people with sickle cell disease. .
CrossRef334
Eva Svarch, Sergio Machín, Rosa María Nieves, Ana Gladys Mancia de Reyes, Marta Navarrete, Hilze Rodríguez. (2006) Hydroxyurea treatment in children with sickle cell anemia in Central America and the Caribbean countries. Pediatric Blood & Cancer 47:1, 111-112
CrossRef335
Hassana Fathallah, George F. Atweh. (2006) DNA hypomethylation therapy for hemoglobin disorders: Molecular mechanisms and clinical applications. Blood Reviews 20:4, 227-234
CrossRef336
Kenneth I. Ataga, Charity G. Moore, Susan Jones, Oludamilola Olajide, Dell Strayhorn, Alan Hinderliter, Eugene P. Orringer. (2006) Pulmonary hypertension in patients with sickle cell disease: a longitudinal study. British Journal of Haematology 134:1, 109-115
CrossRef337
E Voskaridou, E Terpos, S Michail, E Hantzi, A Anagnostopoulos, A Margeli, D Simirloglou, D Loukopoulos, I Papassotiriou. (2006) Early markers of renal dysfunction in patients with sickle cell/β-thalassemia. Kidney International 69:11, 2037-2042
CrossRef338
R T Kamble, C K Tin-U, G Carrum. (2006) Successful mobilization and transplantation of filgrastim mobilized hematopoietic stem cells in sickle cell-hemoglobin C disease. Bone Marrow Transplantation 37:11, 1065-1066
CrossRef339
Brian Laurence, David George, Dexter Woods, Adeyemisi Shosanya, Ralph V. Katz, Sophie Lanzkron, Marie Diener-West, Neil Powe. (2006) The association between sickle cell disease and dental caries in African Americans. Special Care in Dentistry 26:3, 95-100
CrossRef340
Nathalie Dauphin-McKenzie, Jerry M. Gilles, Elvire Jacques, Thomas Harrington. (2006) Sickle Cell Anemia in the Female Patient. Obstetrical & Gynecological Survey 61:5, 343-352
CrossRef341
Alexis A. Thompson. (2006) Advances in the management of sickle cell disease. Pediatric Blood & Cancer 46:5, 533-539
CrossRef342
Ofelia Alvarez, Gaston Zilleruelo, Dale Wright, Brenda Montane, Gabriela Lopez-Mitnik. (2006) Serum cystatin C levels in children with sickle cell disease. Pediatric Nephrology 21:4, 533-537
CrossRef343
Carmen S. P. Lima, Eduardo M. Rocha, Nadia M. Silva, Maria F. Sonatti, Fernando F. Costa, Sara T. O. Saad. (2006) Risk factors for conjunctival and retinal vessel alterations in sickle cell disease. Acta Ophthalmologica Scandinavica 84:2, 234-241
CrossRef344
Luanne L. Peters, Amy J. Lambert, Weidong Zhang, Gary A. Churchill, Carlo Brugnara, Orah S. Platt. (2006) Quantitative trait loci for baseline erythroid traits. Mammalian Genome 17:4, 298-309
CrossRef345
Torsten Baldeweg, Alexandra M. Hogan, Dawn E. Saunders, Paul Telfer, David G. Gadian, Faraneh Vargha-Khadem, Fenella J. Kirkham. (2006) Detecting white matter injury in sickle cell disease using voxel-based morphometry. Annals of Neurology 59:4, 662-672
CrossRef346
Donna K. McClish, James L. Levenson, Lynne T. Penberthy, Susan D. Roseff, Viktor E. Bovbjerg, John D. Roberts, Imoigele P. Aisiku, Wally R. Smith. (2006) Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project. Journal of Women's Health 15:2, 146-154
CrossRef347
Donald Lavelle, Kestis Vaitkus, Maria Hankewych, Mahipal Singh, Joseph DeSimone. (2006) Effect of 5-aza-2′-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the ɛ-, γ-, and β-globin promoters in Papio anubis. Experimental Hematology 34:3, 339-347
CrossRef348
Vanessa Tarer, Maryse Etienne-Julan, Jean-Pierre Diara, Marie Sylvaine Belloy, Martin Mukizi-Mukaza, Jacques Elion, Marc Romana. (2006) Sickle cell anemia in Guadeloupean children: pattern and prevalence of acute clinical events. European Journal of Haematology 76:3, 193-199
CrossRef349
Babatunde O. Onadeko, Rajaa Marouf, Abdelmoneim M. Omar, Zeinat Hijazi, Mousa Khadadah, Mohammed Qurtom, Bert D. Collier, Abdelhamid H. Elgazzar, Adekunle D. Adekile. (2006) Technetium 99m-diethylene triamine penta-acetic acid aerosol clearance in the evaluation of pulmonary involvement in sickle cell disease. European Journal of Haematology 76:2, 147-152
CrossRef350
Martin H Steinberg. 2006. Sickle Cell Disease as a Multifactorial Condition. .
CrossRef351
Lynne Maxwell, Salvatore R. Goodwin, Thomas J. Mancuso, Victor C. Baum, Aaron L. Zuckerberg, Philip G. Morgan, Etsuro K. Motoyama, Peter J. Davis. 2006. Systemic Disorders in Infants and Children. , 1032-1109.
CrossRef352
Lydia Foucan, Didier Ekouevi, Maryse Etienne-Julan, L Rachid Salmi, Jean-Pierre Diara. (2006) Early onset dactylitis associated with the occurrence of severe events in children with sickle cell anaemia. The Paediatric Cohort of Guadeloupe (1984-99). Paediatric and Perinatal Epidemiology 20:1, 59-66
CrossRef353
Hongmei Ren, Kebreab Ghebremeskel, Iheanyi Okpala, Cynthia C. Ugochukwu, Michael Crawford, Obike Ibegbulam. (2006) Abnormality of erythrocyte membrane n-3 long chain polyunsaturated fatty acids in sickle cell haemoglobin C (HbSC) disease is not as remarkable as in sickle cell anaemia (HbSS). Prostaglandins, Leukotrienes and Essential Fatty Acids 74:1, 1-6
CrossRef354
Vahid Afshar-Kharghan, Perumal Thiagarajan. (2006) Leukocyte adhesion and thrombosis. Current Opinion in Hematology 13:1, 34-39
CrossRef355
Lakshmanan Krishnamurti. (2006) Commentary on ???Identification of Unrelated Cord Blood Units for Hematopoietic Stem Cell Transplantation in Children With Sickle Cell Disease???. Journal of Pediatric Hematology/Oncology 28:1, 1-3
CrossRef356
Virginie Zarrouk, Anoosha Habibi, Jean-Ralph Zahar, Fran??oise Roudot-Thoraval, Dora Bachir, Christian Brun-Buisson, Patrick Legrand, Bertrand Godeau, Fr??d??ric Galacteros, Philippe Lesprit. (2006) Bloodstream Infection in Adults With Sickle Cell Disease. Medicine 85:1, 43-48
CrossRef357
Mark W. Crawford, Seth Galton, Mohamed Abdelhaleem. (2005) Preoperative screening for sickle cell disease in children: clinical implications. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 52:10, 1058-1063
CrossRef358
Sadhna M. Shankar, Patrick G. Arbogast, Ed Mitchel, William O. Cooper, Winfred C. Wang, Marie R. Griffin. (2005) Medical care utilization and mortality in sickle cell disease: A population-based study. American Journal of Hematology 80:4, 262-270
CrossRef359
Courtney D. Fitzhugh, Delbert R. Wigfall, Russell E. Ware. (2005) Enalapril and hydroxyurea therapy for children with sickle nephropathy. Pediatric Blood & Cancer 45:7, 982-985
CrossRef360
Osheiza Abdulmalik, Daniel Obeng, Toshio Asakura. (2005) Sickle cell disease: current therapeutic approaches. Expert Opinion on Therapeutic Patents 15:11, 1497-1506
CrossRef361
Darleen R. Powars, Linda S. Chan, Alan Hiti, Emily Ramicone, Cage Johnson. (2005) Outcome of Sickle Cell Anemia. Medicine 84:6, 363-376
CrossRef362
Iris D. Buchanan, Maribel Woodward, George W. Reed. (2005) Opioid selection during sickle cell pain crisis and its impact on the development of acute chest syndrome. Pediatric Blood & Cancer 45:5, 716-724
CrossRef363
Jackie Buck, Sally C. Davies. (2005) Surgery in Sickle Cell Disease. Hematology/Oncology Clinics of North America 19:5, 897-902
CrossRef364
Iheanyi E. Okpala. (2005) New Therapies for Sickle Cell Disease. Hematology/Oncology Clinics of North America 19:5, 975-987
CrossRef365
Elaine Y. Chiang, Paul S. Frenette. (2005) Sickle Cell Vaso-Occlusion. Hematology/Oncology Clinics of North America 19:5, 771-784
CrossRef366
Sam O. Wanko, Marilyn J. Telen. (2005) Transfusion Management in Sickle Cell Disease. Hematology/Oncology Clinics of North America 19:5, 803-826
CrossRef367
Cage S. Johnson. (2005) The Acute Chest Syndrome. Hematology/Oncology Clinics of North America 19:5, 857-879
CrossRef368
Andreia Averci Canalli, Fernando Ferreira Costa, Sara T. O. Saad, Nicola Conran. (2005) Granulocytic adhesive interactions and their role in sickle cell vaso-occlusion. Hematology 10:5, 419-425
CrossRef369
Hongmei Ren, Iheanyi Okpala, Kebreab Ghebremeskel, Cynthia C. Ugochukwu, Obike Ibegbulam, Michael Crawford. (2005) Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease. Annals of Hematology 84:9, 578-583
CrossRef370
Christopher L. Edwards, Mischca T. Scales, Charles Loughlin, Gary G. Bennett, Shani Harris-Peterson, Laura M. De Castro, Elaine Whitworth, Mary Abrams, Miriam Feliu, Stephanie Johnson, Mary Wood, Ojinga Harrison, Alvin Killough. (2005) A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease. International Journal of Behavioral Medicine 12:3, 171-179
CrossRef371
Julie A. Panepinto, Kerry M. O'Mahar, Michael R. DeBaun, Fausto R. Loberiza, J. P. Scott. (2005) Health-related quality of life in children with sickle cell disease: child and parent perception. British Journal of Haematology 130:3, 437-444
CrossRef372
Ersi Voskaridou, Maroussa Douskou, Evangelos Terpos, Alexandra Stamoulakatou, John Meletis, Akis Ourailidis, Ioannis Papassotiriou, Dimitris Loukopoulos. (2005) Deferiprone as an oral iron chelator in sickle cell disease. Annals of Hematology 84:7, 434-440
CrossRef373
J. B. Schnog, T. Teerlink, F. P. L. Dijs, A. J. Duits, F. A. J. Muskiet, . (2005) Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease. Annals of Hematology 84:5, 282-286
CrossRef374
Fernando Ataulfo González, Cristina Blázquez, Paloma Ropero, Olga Briceño, Concha Alaez, Marta Polo, Celina Benavente, Marta Mateo, Ascensión Peña, Ana Villegas, Grupo de Eritropatología. (2005) Asociación de hemoglobinopatía S y alfatalasemia. Análisis de 45 casos. Medicina Clínica 124:19, 726-729
CrossRef375
M. H. Steinberg. (2005) Predicting clinical severity in sickle cell anaemia. British Journal of Haematology 129:4, 465-481
CrossRef376
Roberto F. Machado, Mark T. Gladwin. (2005) Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension. British Journal of Haematology 129:4, 449-464
CrossRef377
Nader A. Khalidi, Harpinder Ajmani, John Varga. (2005) Coexisting Systemic Lupus Erythematosus and Sickle Cell Disease. JCR: Journal of Clinical Rheumatology 11:2, 86-92
CrossRef378
Paola Sebastiani, Marco F Ramoni, Vikki Nolan, Clinton T Baldwin, Martin H Steinberg. (2005) Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nature Genetics 37:4, 435-440
CrossRef379
Eufemia Jacob, Judith E. Beyer, Christine Miaskowski, Marilyn Savedra, Marsha Treadwell, Lori Styles. (2005) Are There Phases to the Vaso-Occlusive Painful Episode in Sickle Cell Disease?. Journal of Pain and Symptom Management 29:4, 392-400
CrossRef380
Duane Robina Bonds. (2005) Three decades of innovation in the management of sickle cell disease: the road to understanding the sickle cell disease clinical phenotype. Blood Reviews 19:2, 99-110
CrossRef381
Osheiza Abdulmalik, Martin K. Safo, Qiukan Chen, Jisheng Yang, Carlo Brugnara, Kwaku Ohene-Frempong, Donald J. Abraham, Toshio Asakura. (2005) 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. British Journal of Haematology 128:4, 552-561
CrossRef382
Coretta Jenerette, Marjorie Funk, Carolyn Murdaugh. (2005) SICKLE CELL DISEASE: A STIGMATIZING CONDITION THAT MAY LEAD TO DEPRESSION. Issues in Mental Health Nursing 26:10, 1081-1101
CrossRef383
Angêla Assis, Nicola Conran, Andreia A. Canalli, Irene Lorand-Metze, Sara T.O. Saad, Fernando F. Costa. (2005) Effect of Cytokines and Chemokines on Sickle Neutrophil Adhesion to Fibronectin. Acta Haematologica 113:2, 130-136
CrossRef384
R.C. Alvim, M.B. Viana, M.A.S. Pires, H.M.O.H. Franklin, M.J. Paula, A.C. Brito, T.F. Oliveira, P.V. Rezende. (2005) Inefficacy of Piracetam in the Prevention of Painful Crises in Children and Adolescents with Sickle Cell Disease. Acta Haematologica 113:4, 228-233
CrossRef385
Charles T. Quinn, Scott T. Miller. (2004) Risk factors and prediction of outcomes in children and adolescents who have sickle cell anemia. Hematology/Oncology Clinics of North America 18:6, 1339-1354
CrossRef386
Navleen Kaur, Bharat Motwani, Devaki Sivasubramaniam, Lori Feldman, Sandra Allen, Richard Ferguson, Gail Shiomoto, David Ansell, Maxwell Westerman, Lawrence Feldman. (2004) Potential role of the ventilation and perfusion (V/Q) lung scan in the diagnosis of acute chest syndrome in adults with sickle cell disease. American Journal of Hematology 77:4, 407-409
CrossRef387
Connie S Birkenmeier, Jane E Barker. (2004) Hereditary haemolytic anaemias: unexpected sequelae of mutations in the genes for erythroid membrane skeletal proteins. The Journal of Pathology 204:4, 450-459
CrossRef388
LeRoy M. Graham. (2004) The Effect of Sickle Cell Disease on the Lung. Clinical Pulmonary Medicine 11:6, 369-378
CrossRef389
Farber, Harrison W., Loscalzo, Joseph, . (2004) Pulmonary Arterial Hypertension. New England Journal of Medicine 351:16, 1655-1665
Full Text390
Yogen Saunthararajah, Joseph DeSimone. (2004) Clinical studies with fetal hemoglobin—enhancing agents in sickle cell disease. Seminars in Hematology 41, 11-16
CrossRef391
Marie J Stuart, Ronald L Nagel. (2004) Sickle-cell disease. The Lancet 364:9442, 1343-1360
CrossRef392
Donald E. Lavelle. (2004) The molecular mechanism of fetal hemoglobin reactivation. Seminars in Hematology 41, 3-10
CrossRef393
Jessica H. Boyd, Asif Moinuddin, Robert C. Strunk, Michael R. DeBaun. (2004) Asthma and acute chest in sickle-cell disease. Pediatric Pulmonology 38:3, 229-232
CrossRef394
Paul G. Firth, C Alvin Head. (2004) Sickle Cell Disease and Anesthesia. Anesthesiology 101:3, 766-785
CrossRef395
Julie A Panepinto, Kerry M O???Mahar, Michael R DeBaun, Kimberly M Rennie, J Paul Scott. (2004) Validity of the Child Health Questionnaire for Use In Children With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 26:9, 574-578
CrossRef396
Yogen Saunthararajah, Donald Lavelle, Joseph DeSimone. (2004) DNA hypo-methylating agents and sickle cell disease. British Journal of Haematology 126:5, 629-636
CrossRef397
Andreia Averci Canalli, Nicola Conran, André Fattori, Sara T.O. Saad, Fernando Ferreira Costa. (2004) Increased adhesive properties of eosinophils in sickle cell disease. Experimental Hematology 32:8, 728-734
CrossRef398
Mark W. Crawford, Melanie Speakman, Edmund D. Carver, Peter C. W. Kim. (2004) Acute chest syndrome shows a predilection for basal lung regions on the side of upper abdominal surgery. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 51:7, 707-711
CrossRef399
Nuno Jorge Velloza Cordeiro, Oluseyi Oniyangi, Nuno Jorge Velloza Cordeiro. 2004. Phytomedicines (medicines derived from plants) for sickle cell disease. .
CrossRef400
Shahid Ahmed, Anita K. Siddiqui, Adnan Sadiq, Rabia K. Shahid, Dilip V Patel, Linda A. Russo. (2004) Echocardiographic abnormalities in sickle cell disease. American Journal of Hematology 76:3, 195-198
CrossRef401
Thomas D.H. McKerrell, Hillel W. Cohen, Henny H. Billett. (2004) The older sickle cell patient. American Journal of Hematology 76:2, 101-106
CrossRef402
Dimitrios I. Zafeiriou, Mara Prengler, Nikos Gombakis, Konsantinos Kouskouras, Marina Economou, Achileas Kardoulas, Chaido Tsantali, Athanasios Dimitriadis, Miranta Athanasiou, Fenella J. Kirkham. (2004) Central nervous system abnormalities in asymptomatic young patients with S?-thalassemia. Annals of Neurology 55:6, 835-839
CrossRef403
Aaron F.H. Lum, Ted Wun, Donald Staunton, Scott I. Simon. (2004) Inflammatory potential of neutrophils detected in sickle cell disease. American Journal of Hematology 76:2, 126-133
CrossRef404
Mir A. Alikhan, Gary Carter, Paulette Mehta. (2004) Topical GM-CSF hastens healing of leg ulcers in sickle cell disease. American Journal of Hematology 76:2, 192-192
CrossRef405
Chaojie Zhang, Xiang Li, Lurong Lian, Qiukan Chen, Osheiza Abdulmalik, Vasco Vassilev, Ching-San Lai, Toshio Asakura. (2004) Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents. British Journal of Haematology 125:6, 788-795
CrossRef406
Vishwas S. Sakhalkar, Sreedhar P. Rao, Jeremy Weedon, Scott T. Miller. (2004) Elevated plasma sVCAM-1 levels in children with sickle cell disease: Impact of chronic transfusion therapy. American Journal of Hematology 76:1, 57-60
CrossRef407
J.B. Schnog, M.R. Mac Gillavry, A.P. van Zanten, J.C.M. Meijers, R.A. Rojer, A.J. Duits, H. ten Cate, D.P.M. Brandjes. (2004) Protein C and S and inflammation in sickle cell disease. American Journal of Hematology 76:1, 26-32
CrossRef408
Franco Locatelli, Piero De Stefano. (2004) New insights into haematopoietic stem cell transplantation for patients with haemoglobinopathies. British Journal of Haematology 125:1, 3-11
CrossRef409
Iheanyi Okpala. (2004) The intriguing contribution of white blood cells to sickle cell disease – a red cell disorder. Blood Reviews 18:1, 65-73
CrossRef410
Anil K. Saxena, B. R. Panhotra, Ali M. Al-Arabi Al-Ghamdi. (2004) Should early renal transplantation be deemed necessary among patients with end-stage sickle cell nephropathy who are receiving hemodialytic therapy?. Transplantation 77:6, 955
CrossRef411
Gladwin, Mark T., Sachdev, Vandana, Jison, Maria L., Shizukuda, Yukitaka, Plehn, Jonathan F., Minter, Karin, Brown, Bernice, Coles, Wynona A., Nichols, James S., Ernst, Inez, Hunter, Lori A., Blackwelder, William C., Schechter, Alan N., Rodgers, Griffin P., Castro, Oswaldo, Ognibene, Frederick P., . (2004) Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease. New England Journal of Medicine 350:9, 886-895
Full Text412
LeRoy M. Graham. (2004) Sickle cell disease: Pulmonary management options. Pediatric Pulmonology 37:S26, 191-193
CrossRef413
K. Sharan, S. Surrey, S. Ballas, M. Borowski, M. Devoto, K.-F. Wang, E. Sandler, M. Keller. (2004) Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease. British Journal of Haematology 124:2, 240-243
CrossRef414
Suparno Chakrabarti, David Bareford. (2004) Will developments in allogeneic transplantation influence treatment of adult patients with sickle cell disease?. Biology of Blood and Marrow Transplantation 10:1, 23-31
CrossRef415
William H. Schultz, Russell E. Ware. (2003) Malignancy in patients with sickle cell disease. American Journal of Hematology 74:4, 249-253
CrossRef416
Robert C Atkins, Mark C Walters. (2003) Haematopoietic cell transplantation in the treatment of sickle cell disease. Expert Opinion on Biological Therapy 3:8, 1215-1224
CrossRef417
S Diop, S.O Mokono, M Ndiaye, A.O Touré Fall, D Thiam, L Diakhaté. (2003) La drépanocytose homozygote après l’âge de 20 ans : suivi d’une cohorte de 108 patients au CHU de Dakar. La Revue de Médecine Interne 24:11, 711-715
CrossRef418
NJV Cordeiro, O Oniyangi. 2003. Phytomedicines (medicines derived from plants) for sickle cell disease. .
CrossRef419
Elizabeth A. Manci, Donald E. Culberson, Yih-Ming Yang, Todd M. Gardner, Randall Powell, Johnson Haynes, Arvind K. Shah, Vipul N. Mankad, . (2003) Causes of death in sickle cell disease: an autopsy study. British Journal of Haematology 123:2, 359-365
CrossRef420
Christiane Vermylen. (2003) Hematopoietic stem cell transplantation in sickle cell disease. Blood Reviews 17:3, 163-166
CrossRef421
Ronald L. Nagel, Mary E. Fabry, Martin H. Steinberg. (2003) The paradox of hemoglobin SC disease. Blood Reviews 17:3, 167-178
CrossRef422
Jennifer M Knight-Madden, Ian R Hambleton, Jennifer M Knight-Madden. 2003. Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. .
CrossRef423
O Oniyangi, AAA Omari, Oluseyi Oniyangi. 2003. Malaria chemoprophylaxis in sickle cell disease. .
CrossRef424
Janie A. Ho, Chrisley V. Pickens, Michael P. Gamscik, O.Michael Colvin, Russell E. Ware. (2003) In vitro induction of fetal hemoglobin in human erythroid progenitor cells. Experimental Hematology 31:7, 586-591
CrossRef425
Warwick A. Marchant, Isabeau Walker. (2003) Anaesthetic management of the child with sickle cell disease. Pediatric Anesthesia 13:6, 473-489
CrossRef426
Robert L. Casey, Ronald T. Brown. (2003) Psychological aspects of hematologic diseases. Child and Adolescent Psychiatric Clinics of North America 12:3, 567-584
CrossRef427
Merry Jennifer Markham, Richard Lottenberg, Marc Zumberg. (2003) Role of phlebotomy in the management of hemoglobin SC disease: Case report and review of the literature. American Journal of Hematology 73:2, 121-125
CrossRef428
Sally C Davies, Annette Gilmore. (2003) The role of hydroxyurea in the management of sickle cell disease. Blood Reviews 17:2, 99-109
CrossRef429
Christopher E.D. Lamming, Lance Augustin, Mark Blackstad, Troy C. Lund, Robert P. Hebbel, Catherine M. Verfaillie. (2003) Spontaneous circulation of myeloid-lymphoid–initiating cells and SCID-repopulating cells in sickle cell crisis. Journal of Clinical Investigation 111:6, 811-819
CrossRef430
Allan M. Judd, Katrina B. Best, Kathrine Christensen, George M. Rodgers, John D. Bell. (2003) Alterations in sensitivity to calcium and enzymatic hydrolysis of membranes from sickle cell disease and trait erythrocytes. American Journal of Hematology 72:3, 162-169
CrossRef431
Rajinder Prasad, Syed Hasan, Oswaldo Castro, Elliott Perlin, Kyungsook Kim. (2003) Long-Term Outcomes in Patients with Sickle Cell Disease and Frequent Vaso-Occlusive Crises. The American Journal of the Medical Sciences 325:3, 107-109
CrossRef432
David C Rees, Ade D. Olujohungbe, Norman E. Parker, Adrian D. Stephens, Paul Telfer, Josh Wright. (2003) Guidelines for the management of the acute painful crisis in sickle cell disease. British Journal of Haematology 120:5, 744-752
CrossRef433
Persis J. Amrolia, Antonio Almeida, Sally C. Davies, Irene A. G. Roberts. (2003) Therapeutic challenges in childhood sickle cell disease Part 2: a problem-orientated approach. British Journal of Haematology 120:5, 737-743
CrossRef434
Reda E. Girgis, Mohammed A. Qureshi, Judith Abrams, Paul Swerdlow. (2003) Decreased exhaled nitric oxide in sickle cell disease: Relationship with chronic lung involvement. American Journal of Hematology 72:3, 177-184
CrossRef435
Christopher D. Reiter, Mark T. Gladwin. (2003) An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy. Current Opinion in Hematology 10:2, 99-107
CrossRef436
Martin H. Steinberg, Carlo Brugnara. (2003) Pathophysiological-Based Approaches to Treatment of Sickle Cell Disease. Annual Review of Medicine 54:1, 89-112
CrossRef437
Javid Gaziev, Guido Lucarelli. (2003) Stem cell transplantation for hemoglobinopathies. Current Opinion in Pediatrics 15:1, 24-31
CrossRef438
Martin H. Steinberg, Ersi Voskaridou, Abdullah Kutlar, Dimitris Loukopoulos, Mabel Koshy, Samir K. Ballas, Oswaldo Castro, Franca Barton. (2003) Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease. American Journal of Hematology 72:2, 121-126
CrossRef439
Christina Halsey, Irene A. G. Roberts. (2003) The role of hydroxyurea in sickle cell disease. British Journal of Haematology 120:2, 177-186
CrossRef440
R.H. Glew, J. Casados, Y.-S. Huang, L.-T. Chuang, D.J. VanderJagt. (2003) Correlation of the fatty acid composition and fluid property of the cholesteryl esters in the serum of Nigerian children with sickle cell disease and healthy controls. Prostaglandins, Leukotrienes and Essential Fatty Acids 68:1, 61-68
CrossRef441
Linda M.S. Resar, Jodi B. Segal, Lorna K. Fitzpatric, Alison Friedmann, Saul W. Brusilow, George J. Dover. (2002) Induction of Fetal Hemoglobin Synthesis in Children With Sickle Cell Anemia on Low-Dose Oral Sodium Phenylbutyrate Therapy. Journal of Pediatric Hematology/Oncology 24:9, 737-741
CrossRef442
Alexandra Dorn-Beineke, Thomas Frietsch. (2002) Sickle Cell Disease – Pathophysiology, Clinical and Diagnostic Implications. Clinical Chemistry and Laboratory Medicine 40:11, 1075-1084
CrossRef443
Abraham Sumoza, Renate de Bisotti, David Sumoza, Virgil Fairbanks. (2002) Hydroxyurea (HU) for prevention of recurrent stroke in sickle cell anemia (SCA). American Journal of Hematology 71:3, 161-165
CrossRef444
Thomas P. Nifong, Ronald E. Domen. (2002) Oxygen Saturation and Hemoglobin A Content in Patients with Sickle Cell Disease Undergoing Erythrocytapheresis. Therapeutic Apheresis and Dialysis 6:5, 390-393
CrossRef445
R.H. Glew, J.K. Casados, Y.-S. Huang, L.-T. Chuang, D.J. VanderJagt. (2002) The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. Prostaglandins, Leukotrienes and Essential Fatty Acids 67:4, 217-222
CrossRef446
Robert Iannone, Allen R. Chen, James F. Casella. (2002) Commentary on “Summary of Symposium: The Future of Stem Cell Transplantation for Sickle Cell Disease”. Journal of Pediatric Hematology/Oncology 24:7, 515-517
CrossRef447
C.T Escoffery, S.E Shirley. (2002) Causes of sudden natural death in Jamaica: a medicolegal (coroner’s) autopsy study from the University Hospital of the West Indies. Forensic Science International 129:2, 116-121
CrossRef448
Ceri Hirst, Shirley Owusu-Ofori, Ceri Hirst. 2002. Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. .
CrossRef449
Darleen R. Powars, Alan Hiti, Emily Ramicone, Cage Johnson, Linda Chan. (2002) Outcome in hemoglobin SC disease: A four-decade observational study of clinical, hematologic, and genetic factors. American Journal of Hematology 70:3, 206-215
CrossRef450
Donald E. Wesson. (2002) The initiation and progression of sickle cell nephropathy. Kidney International 61:6, 2277-2286
CrossRef451
Carlo Brugnara, Martin H Steinberg. (2002) Developing treatment for sickle cell disease. Expert Opinion on Investigational Drugs 11:5, 645-659
CrossRef452
Hilary A Blacklock. (2002) Iron therapy and haemoglobinopathies in end-stage renal failure. Nephrology 7, S48-S49
CrossRef453
TED WUN, MIGUEL CORDOBA, ARUN RANGASWAMI, ANTHONY W. CHEUNG, TERESA PAGLIERONI. (2002) Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease*. Clinical and Laboratory Haematology 24:2, 81-88
CrossRef454
Hilary A BLACKLOCK. (2002) Iron therapy and haemoglobinopathies in end-stage renal failure. Nephrology 7:s1, S48-S49
CrossRef455
Nabil Saba, Thomas Flaig. (2002) Bone Marrow Transplantation for Nonmalignant Diseases. Journal of Hematotherapy <html_ent glyph="@amp;" ascii="&"/> Stem Cell Research 11:2, 377-387
CrossRef456
Paul S. Frenette. (2002) Sickle cell vaso-occlusion: multistep and multicellular paradigm. Current Opinion in Hematology 9:2, 101-106
CrossRef457
Ryad Tamouza, Maria-Grazia Neonato, Marc Busson, François Marzais, Robert Girot, Dominique Labie, Jacques Elion, Dominique Charron. (2002) Infectious complications in sickle cell disease are influenced by HLA class II alleles. Human Immunology 63:3, 194-199
CrossRef458
Constance F.M. Danielson. (2002) The Role of Red Blood Cell Exchange Transfusion in the Treatment and Prevention of Complications of Sickle Cell Disease. Therapeutic Apheresis and Dialysis 6:1, 24-31
CrossRef459
Ana Lúcia Teixeira, Marcos Borato Viana, Mariza Leitão Valadares Roquete, Nivaldo Hartung Toppa. (2002) Sickle Cell Disease: A Clinical and Histopathologic Study of the Liver in Living Children. Journal of Pediatric Hematology/Oncology 24:2, 125-129
CrossRef460
James G. Taylor VI, Delia Tang, Charles B. Foster, Graham R. Serjeant, Griffin P. Rodgers, Stephen J. Chanock. (2002) Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease. American Journal of Hematology 69:2, 109-114
CrossRef461
Samir K. Ballas. (2002) Sickle Cell Anaemia. Drugs 62:8, 1143-1172
CrossRef462
Paul J. Nietert, Marc D. Silverstein, Miguel R. Abboud. (2002) Sickle Cell Anaemia. PharmacoEconomics 20:6, 357-366
CrossRef463
Michael Schleuning, Oliver Stoetzer, Christine Waterhouse, Markus Schlemmer, Georg Ledderose, Hans-Jochem Kolb. (2002) Hematopoietic stem cell transplantation after reduced-intensity conditioning as treatment of sickle cell disease. Experimental Hematology 30:1, 7-10
CrossRef464
G Vassiliou, P Amrolia, I.A.G Roberts. (2001) Allogeneic transplantation for haemoglobinopathies. Best Practice & Research Clinical Haematology 14:4, 807-822
CrossRef465
George F Atweh, Dimitris Loukopoulos. (2001) Pharmacological induction of fetal hemoglobin in sickle cell disease and β-thalassemia. Seminars in Hematology 38:4, 367-373
CrossRef466
Martin H Steinberg, Griffin P Rodgers. (2001) Pathophysiology of sickle cell disease: Role of cellular and genetic modifiers. Seminars in Hematology 38:4, 299-306
CrossRef467
MARTIN H. STEINBERG, GRIFFIN P. RODGERS. (2001) Pharmacologic Modulation of Fetal Hemoglobin. Medicine 80:5, 328-344
CrossRef468
DIETER BRUNO, DELBERT R. WIGFALL, SHERRI A. ZIMMERMAN, PHILIP M. ROSOFF, JOHN S. WIENER. (2001) GENITOURINARY COMPLICATIONS OF SICKLE CELL DISEASE. The Journal of Urology803-811
CrossRef469
DIETER BRUNO, DELBERT R. WIGFALL, SHERRI A. ZIMMERMAN, PHILIP M. ROSOFF, JOHN S. WIENER. (2001) GENITOURINARY COMPLICATIONS OF SICKLE CELL DISEASE. The Journal of Urology 166:3, 803-811
CrossRef470
Ceri Hirst, Lorna Williamson, Ceri Hirst. 2001. Preoperative blood transfusions for sickle cell disease. .
CrossRef471
W. A. Marchant, S. Wright, J. B. Porter. (2001) Coronary artery bypass graft surgery in a patient with haemoglobin SC disease. Anaesthesia 56:7, 667-669
CrossRef472
CAROLYN E. IEVERS-LANDIS, RONALD T. BROWN, DENNIS DROTAR, VICKI BUNKE, RICHARD G. LAMBERT, A. ADRIENNE WALKER. (2001) Situational Analysis of Parenting Problems for Caregivers of Children with Sickle Cell Syndromes. Journal of Developmental & Behavioral Pediatrics 22:3, 169-178
CrossRef473
M DUGDALE. (2001) ANEMIA. Obstetrics and Gynecology Clinics of North America 28:2, 363-382
CrossRef474
William Reed, Elliott P. Vichinsky. (2001) Transfusion Therapy: A Coming-of-Age Treatment for Patients With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 23:4, 197-202
CrossRef475
B Godeau, V Noël, A Habibi, A Schaeffer, D Bachir, F Galactéros. (2001) La drépanocytose chez lˈadulte : quelles urgences pour l’interniste ?. La Revue de Médecine Interne 22:5, 440-451
CrossRef476
Ashley P Jones, Sally C Davies, Adebayo Olujohungbe, Ashley P Jones. 2001. Hydroxyurea for sickle cell disease. .
CrossRef477
Carolyn C. Hoppe, Mark C. Walters. (2001) Bone marrow transplantation in sickle cell anemia. Current Opinion in Oncology 13:2, 85-90
CrossRef478
W. A. Marchant, S. Wright. (2001) Aortic cross-clamping in sickle cell disease. Anaesthesia 56:3, 286-287
CrossRef479
Karl A. Nath, Joseph P. Grande, Jill J. Haggard, Anthony J. Croatt, Zvonimir S. Katusic, Anna Solovey, Robert P. Hebbel. (2001) Oxidative Stress and Induction of Heme Oxygenase-1 in the Kidney in Sickle Cell Disease. The American Journal of Pathology 158:3, 893-903
CrossRef480
T. Frietsch, I. Ewen, K. F. Waschke. (2001) Anaesthetic care for sickle cell disease. European Journal of Anaesthesiology 18:3, 137-150
CrossRef481
Marie J. Stuart, B.N. Yamaja Setty. (2001) Acute chest syndrome of sickle cell disease: new light on an old problem. Current Opinion in Hematology 8:2, 111-122
CrossRef482
Klaas JJ Wierenga, Ian R Hambleton, Norma A Lewis, Sickle Cell Unit. (2001) Survival estimates for patients with homozygous sickle-cell disease in Jamaica: a clinic-based population study. The Lancet 357:9257, 680-683
CrossRef483
George F. Atweh, Alan N. Schechter. (2001) Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease. Current Opinion in Hematology 8:2, 123-130
CrossRef484
David H. K. Chui, George J. Dover. (2001) Sickle cell disease: no longer a single gene disorder. Current Opinion in Pediatrics 13:1, 22-27
CrossRef485
Donald Lavelle, Robert Molokie, Janice Ducksworth, Joseph DeSimone. (2001) Effects of hydroxurea, stem cell factor, and erythropoietin in combination on fetal hemoglobin in the baboon. Experimental Hematology 29:2, 156-162
CrossRef486
Graham R. Serjeant. (2001) The emerging understanding of sickle cell disease. British Journal of Haematology 112:1, 3-18
CrossRef487
LAURA STOBER LARSEN, SUSAN G. NEVERETT, RICHARD F. LARSEN. (2001) Clinical Nurse Specialist as Facilitator of Interdisciplinary Collaborative Program for Adult Sickle Cell Population. Clinical Nurse Specialist 15:1, 15-22
CrossRef488
B. Godeau. (2000) La drépanocytose chez l'adulte : quelles urgences pour l'interniste ?. La Revue de Médecine Interne 21, 436-438
CrossRef489
Sara W. Day, Lynn Witte Wynn. (2000) Sickle Cell Pain & Hydroxyurea. American Journal of Nursing 100:11, 34-39
CrossRef490
Miguel R. Abboud, Ellen C. Taylor, David Habib, Terrie Dantzler-Johnson, Sherron M. Jackson, Fushen Xu, Joseph Laver, Samir K. Ballas. (2000) Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. British Journal of Haematology 111:2, 482-490
CrossRef491
Paul G. Firth, Robert A. Peterfreund. (2000) Management of Multiple Intracranial Aneurysms: Neuroanesthetic Considerations of Sickle Cell Disease. Journal of Neurosurgical Anesthesiology 12:4, 366-371
CrossRef492
Dimitris Loukopoulos, Ersi Voskaridou, Vassiliki Kalotychou, Maria Schina, Aphrodite Loutradi, Ilias Theodoropoulos. (2000) Reduction of the Clinical Severity of Sickle Cell/β-Thalassemia with Hydroxyurea: The Experience of a Single Center in Greece. Blood Cells, Molecules, and Diseases 26:5, 453-466
CrossRef493
Robert Edwards, Joseph Telfair, Heather Cecil, Jennifer Lenoci. (2000) Reliability and validity of a self-efficacy instrument specific to sickle cell disease. Behaviour Research and Therapy 38:9, 951-963
CrossRef494
Colin G Steward. (2000) Stem cell transplantation for non-malignant disorders. Best Practice & Research Clinical Haematology 13:3, 343-363
CrossRef495
Orah S. Platt. (2000) Sickle cell anemia as an inflammatory disease. Journal of Clinical Investigation 106:3, 337-338
CrossRef496
Carolyn Hoppe, Elliott Vichinsky, Keith Quirolo, Jane Van Warmerdam, Katie Allen, Lori Styles. (2000) Use of Hydroxyurea in Children Ages 2 to 5 Years With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 22:4, 330-334
CrossRef497
Platt, Orah S., . (2000) The Acute Chest Syndrome of Sickle Cell Disease. New England Journal of Medicine 342:25, 1904-1907
Full Text498
Vichinsky, Elliott P., Neumayr, Lynne D., Earles, Ann N., Williams, Roger, Lennette, Evelyne T., Dean, Deborah, Nickerson, Bruce, Orringer, Eugene, McKie, Virgil, Bellevue, Rita, Daeschner, Charles, Abboud, Miguel, Moncino, Mark, Ballas, Samir, Ware, Russell, Manci, Elizabeth A., . (2000) Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease. New England Journal of Medicine 342:25, 1855-1865
Full Text499
Susan Claster, Elliott Vichinsky. (2000) Acute Chest Syndrome in Sickle Cell Disease: Pathophysiology and Management. Journal of Intensive Care Medicine 15:3, 159-166
CrossRef500
Samir K Ballas. (2000) Acute Chest Syndrome in Sickle Cell Anemia. Journal of Intensive Care Medicine 15:3, 123-125
CrossRef501
(2000) Prediction of Adverse Outcomes in Children with Sickle Cell Disease. New England Journal of Medicine 342:21, 1612-1613
Full Text502
Rathi Iyer, Radhakrishna Baliga, Ronald L. Nagel, Carlo Brugnara, Kent Kirchner, Shirley Hogan, Martin H. Steinberg. (2000) Maximum urine concentrating ability in children with Hb SC disease: Effects of hydroxyurea. American Journal of Hematology 64:1, 47-52
CrossRef503
Mark T Gladwin, Griffin P Rodgers. (2000) Pathogenesis and treatment of acute chest syndrome of sickle-cell anaemia. The Lancet 355:9214, 1476-1478
CrossRef504
Eugenia K. Cronin, Charles Normand, Joan S. Henthorn, Vesna Graham, Sally C. Davies. (2000) Organisation and cost-effectiveness of antenatal haemoglobinopathy screening and follow up in a community-based programme. BJOG: An International Journal of Obstetrics and Gynaecology 107:4, 486-491
CrossRef505
W. Reed, P. Walker, T. Haddix, H.A. Perkins. (2000) Acute anemic events in sickle cell disease. Transfusion 40:3, 267-273
CrossRef506
Darleen R. Powars. (2000) Management Of Cerebral Vasculopathy In Children With Sickle Cell Anaemia. British Journal of Haematology 108:4, 666-678
CrossRef507
Petra Ladwig, Henry Murray. (2000) Sickle cell disease in pregnancy. The Australian and New Zealand Journal of Obstetrics and Gynaecology 40:1, 97-100
CrossRef508
De Franceschi, Bachir, Galacteros, Tchernia, Cynober, Neuberg, Beuzard, Brugnara. (2000) Oral magnesium pidolate: effects of long-term administration in patients with sickle cell disease. British Journal of Haematology 108:2, 284-289
CrossRef509
Miller, Scott T., Sleeper, Lynn A., Pegelow, Charles H., Enos, Laura E., Wang, Winfred C., Weiner, Steven J., Wethers, Doris L., Smith, Jeanne, Kinney, Thomas R., . (2000) Prediction of Adverse Outcomes in Children with Sickle Cell Disease. New England Journal of Medicine 342:2, 83-89
Full Text510
C. Le Turdu-Chicot, L. Foucan, M. Étienne-Julan, Y. Leborgne-Samuel, R. Fanhan, C. Berchel. (2000) Analyse des hospitalisations chez les patients drépanocytaires adultes en Guadeloupe. La Revue de Médecine Interne 21:1, 24-29
CrossRef511
Timothy E Mitchell, Martin H Steinberg. (1999) Novel approaches to treatment of sickle cell anaemia. Expert Opinion on Investigational Drugs 8:11, 1823-1836
CrossRef512
Oswaldo Castro. (1999) MANAGEMENT OF SICKLE CELL DISEASE: RECENT ADVANCES AND CONTROVERSIES. British Journal of Haematology 107:1, 2-11
CrossRef513
Prasad Rao Koduri, Monica Leon, George R. Honig, Shi-Jiang Lu. (1999) A 78-year-old man with sickle-cell anemia. American Journal of Hematology 62:1, 62-62
CrossRef514
Jennifer Knight, Thomas M. Murphy, Iley Browning. (1999) The lung in sickle cell disease. Pediatric Pulmonology 28:3, 205-216
CrossRef515
Paul J. Nietert, Miguel R. Abboud, James S. Zoller, Marc D. Silverstein. (1999) Costs, Charges, and Reimbursements for Persons With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 21:5, 389-396
CrossRef516
Stacy J. Marcus, Russell E. Ware. (1999) Physiologic Decline in Fetal Hemoglobin Parameters in Infants With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 21:5, 407-411
CrossRef517
R.Grant Steen, James W. Langston, Robert J. Ogg, Xioping Xiong, Zhengzheng Ye, Winfred C. Wang. (1999) Diffuse T1 reduction in gray matter of sickle cell disease patients: evidence of selective vulnerability to damage?. Magnetic Resonance Imaging 17:4, 503-515
CrossRef518
David W. Emery, Fionnuala Morrish, Qiliang Li, George Stamatoyannopoulos. (1999) Analysis of gamma-Globin Expression Cassettes in Retrovirus Vectors. Human Gene Therapy 10:6, 877-888
CrossRef519
Wood, Alastair J.J., , Steinberg, Martin H., . (1999) Management of Sickle Cell Disease. New England Journal of Medicine 340:13, 1021-1030
Full Text520
S. E. Lawson, S. Oakley, N. A. Smith, D. Bareford. (1999) Red cell exchange in sickle cell disease. Clinical & Laboratory Haematology 21:2, 99-102
CrossRef521
C. C. Anyaegbu, I. E. Okpala, A. Y. Aken'Ova, L. S. Salimonu. (1999) Complement haemolytic activity, circulating immune complexes and the morbidity of sickle cell anaemia. APMIS 107:7-12, 699-702
CrossRef522
Kathleen Gorman. (1999) Sickle Cell Disease. American Journal of Nursing 99:3, 38-43
CrossRef523
R. Grant Steen, Xioping Xiong, Raymond K. Mulhern, James W. Langston, Winfred C. Wang. (1999) Subtle brain abnormalities in children with sickle cell disease: Relationship to blood hematocrit. Annals of Neurology 45:3, 279-286
CrossRef524
J.G. Wright, I.R. Hambleton, P.W. Thomas, N.D. Duncan, S. Venugopal, G.R. Serjeant. (1999) Postsplenectomy course in homozygous sickle cell disease. The Journal of Pediatrics 134:3, 304-309
CrossRef525
Elpis Mantadakis, Zora R. Rogers, Angela K. Smith, Raymond Quigley, Arleen F. Ratliff, Barton A. Kamen. (1999) Delayed Methotrexate Clearance in a Patient With Sickle Cell Anemia and Osteosarcoma. Journal of Pediatric Hematology/Oncology 21:2, 165-169
CrossRef526
M. Hickman, B. Modell, P. Greengross, C. Chapman, M. Layton, S. Falconer, S. C. Davies. (1999) Mapping the prevalence of sickle cell and beta thalassaemia in England: estimating and validating ethnic-specific rates. British Journal of Haematology 104:4, 860-867
CrossRef527
M. A. Ware, I. Hambleton, I. Ochaya, G. R. Serjeant. (1999) Day-care management of sickle cell painful crisis in Jamaica: a model applicable elsewhere?. British Journal of Haematology 104:1, 93-96
CrossRef528
Solomon F. Ofori-Acquah, Michel R.A. Lalloz, D.Mark Layton. (1999) Localisation ofcisRegulatory Elements at the β-Globin Locus: Analysis of Hybrid Haplotype Chromosomes. Biochemical and Biophysical Research Communications 254:1, 181-187
CrossRef529
Sherri A. Zimmerman, Russell E. Ware. (1998) Inherited DNA mutations contributing to thrombotic complications in patients with Sickle cell disease. American Journal of Hematology 59:4, 267-272
CrossRef530
Liesner, Mackie, Cookson, McDonald, Chitolie, Donohoe, Evans, Hann, Machin. (1998) Prothrombotic changes in children with sickle cell disease: relationships to cerebrovascular disease and transfusion. British Journal of Haematology 103:4, 1037-1044
CrossRef531
A. J. Vipond, L. D. Caldicott. (1998) Major vascular surgery in a patient with sickle cell disease. Anaesthesia 53:12, 1204-1206
CrossRef532
A. J. Duits, J. B. Schnog, L. R. Lard, A.W. Saleh, R. A. Rojer. (1998) Elevated IL-8 levels during sickle cell crisis. European Journal of Haematology 61:5, 302-305
CrossRef533
Joshua H. Bilenker, Wendy E. Weller, Thomas J. Shaffer, George J. Dover, Gerard F. Anderson. (1998) The Costs of Children With Sickle Cell Anemia. Journal of Pediatric Hematology/Oncology 20:6, 528-533
CrossRef534
Thomas Muehlberger, Lesley Wong, Rick Redett, John A. Girotto, Andrew M. Munster. (1998) A Temporal Correlation of Pain and Endotoxin Levels in Sickle Cell Disease. The Journal of Trauma: Injury, Infection, and Critical Care 45:4, 814-815
CrossRef535
Fernanda L. Andrade, Joyce M. Annichino-Bizzacchi, Sara T. O. Saad, Fernando F. Costa, Valder R. Arruda. (1998) Prothrombin mutant, factor V Leiden, and thermolabile variant of methylenetetrahidrofolate reductase among patients with sickle cell disease in Brazil. American Journal of Hematology 59:1, 46-50
CrossRef536
DM Layton, GJ Mufti. (1998) Opiates for sickle-cell crisis?. The Lancet 351:9120, 1964-1965
CrossRef537
John-John B. Schnog, Leroy R. Lard, Robert A. Rojer, Fey P. L. Van der Dijs, Frits A. J. Muskiet, Ashley J. Duits. (1998) New concepts in assessing sickle cell disease severity. American Journal of Hematology 58:1, 61-66
CrossRef538
R. Grant Steen, Wilburn E. Reddick, Raymond K. Mulhern, James W. Langston, Robert J. Ogg, Andrea A. Bieberich, Peter B. Kingsley, Winfred C. Wang. (1998) Quantitative MRI of the brain in children with sickle cell disease reveals abnormalities unseen by conventional MRI. Journal of Magnetic Resonance Imaging 8:3, 535-543
CrossRef539
Veronica Nicky Thomas, Jenifer Wilson-Barnett, Frances Goodhart. (1998) The role of cognitive-behavioural therapy in the management of pain in patients with sickle cell disease. Journal of Advanced Nursing 27:5, 1002-1009
CrossRef540
C.C. Anyaegbu, I.E. Okpala, Y.A. Aken'Ova, L.S. Salimonu. (1998) Peripheral blood neutrophil count and candidacidal activity correlate with the clinical severity of sickle cell anaemia (SCA). European Journal of Haematology 60:4, 267-268
CrossRef541
Martin H. Steinberg. (1998) 6 Pathophysiology of sickle cell disease. Baillière's Clinical Haematology 11:1, 163-184
CrossRef542
C. Anthony Blau. (1998) 10 Current status of stem cell therapy and prospects for gene therapy for the disorders of globin synthesis. Baillière's Clinical Haematology 11:1, 257-275
CrossRef543
Ted Wun, Teresa Paglieroni, Arun Rangaswami, Patricia Hill Franklin, Jeanna Welborn, Anthony Cheung, Fern Tablin. (1998) Platelet activation in patients with sickle cell disease. British Journal of Haematology 100:4, 741-749
CrossRef544
Griffin P. Rodgers. (1998) 9 Pharmacological therapy. Baillière's Clinical Haematology 11:1, 239-255
CrossRef545
Miguel Abboud, Joseph Laver, C Anthony Blau. (1998) Granulocytosis causing sickle-cell crisis. The Lancet 351:9107, 959
CrossRef546
Lynne Neumayr, Mabel Koshy, Charles Haberkern, Ann Noonan Earles, Rita Bellevue, Kathryn Hassell, Scott Miller, Dennis Black, Elliott Vichinsky, . (1998) Surgery in patients with hemoglobin SC disease. American Journal of Hematology 57:2, 101-108
CrossRef547
W. Reed, MD, E. P. Vichinsky, MD. (1998) NEW CONSIDERATIONS IN THE TREATMENT OF SICKLE CELL DISEASE. Annual Review of Medicine 49:1, 461-474
CrossRef548
Iheanyi Okpala. (1998) The management of crisis in sickle cell disease. European Journal of Haematology 60:1, 1-6
CrossRef549
Nancy F. Olivieri, Elliott P. Vichinsky. (1998) Hydroxyurea in Children with Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 20:1, 26-31
CrossRef550
Phuong-Thu Pham, Susie Quong Lew, James E. Balow. (1997) Sickle cell nephropathy during the postpartum period in a patient with SLE. American Journal of Kidney Diseases 30:6, 879-883
CrossRef551
Andrew M. Atz, David L. Wessel. (1997) Inhaled Nitric Oxide in Sickle Cell Disease with Acute Chest Syndrome. Anesthesiology 87:4, 988-990
CrossRef552
Anastassios C. Koumbourlis, Anne Hurlet-Jensen, Michael R. Bye. (1997) Lung function in infants with sickle cell disease. Pediatric Pulmonology 24:4, 277-281
CrossRef553
Graham R Serjeant. (1997) Sickle-cell disease. The Lancet 350:9079, 725-730
CrossRef554
Maria A. Pelidis, Gregory J. Kato, Linda M. S. Resar, George J. Dover, David G. Nichols, Linda K. Walker, James F. Casella. (1997) Successful Treatment of Life-Threatening Acute Chest Syndrome of Sickle Cell Disease with Venovenous Extracorporeal Membrane Oxygenation. Journal of Pediatric Hematology/Oncology 19:5, 459-461
CrossRef555
J. C. Romero Mestre, A. Hernández, O. Agramonte, P. Hernández. (1997) Cardiovascular autonomic dysfunction in sickle cell anemia: A possible risk factor for sudden death?. Clinical Autonomic Research 7:3, 121-125
CrossRef556
Francis J. Keefe, Marlene Jacobs, Lynn Underwood-Gordon. (1997) Biobehavioral Pain Research: A Multi-Institute Assessment of Cross-Cutting Issues and Research Needs. The Clinical Journal of Pain 13:2, 91-103
CrossRef557
Finetta L. Reese, Wally R. Smith. (1997) Psychosocial determinants of health care utilization in sickle cell disease patients. Annals of Behavioral Medicine 19:2, 171-178
CrossRef558
J HICKMAN, P LACHIEWICZ. (1997) Results and complications of total hip arthroplasties in patients with sickle-cell hemoglobinopathies Role of cementless components. The Journal of Arthroplasty 12:4, 420-425
CrossRef559
Maxwell P. Westerman, Keeya Bailey, Sally Freels, Robert Schlegel, Patrick Williamson. (1997) Assessment of painful episode frequency in sickle-cell disease. American Journal of Hematology 54:3, 183-188
CrossRef560
T.R. Jones. (1997) Quantitative aspects of the relationship between the sickle-cell gene and malaria. Parasitology Today 13:3, 107-111
CrossRef561
Nancy F. Olivieri. (1997) Fetal erythropoiesis and the diagnosis and treatment of hemoglobin disorders in the fetus and child. Seminars in Perinatology 21:1, 63-69
CrossRef562
P.W. Thomas, D.R. Higgs, G.R. Serjeant. (1997) Benign clinical course in homozygous sickle cell disease: A search for predictors. Journal of Clinical Epidemiology 50:2, 121-126
CrossRef563
Samir K. Ballas, Narla Mohandas. (1996) PATHOPHYSIOLOGY OF VASO-OCCLUSION. Hematology/Oncology Clinics of North America 10:6, 1221-1239
CrossRef564
SAMUEL CHARACHE, CAGE S. JOHNSON. (1996) PREFACE. Hematology/Oncology Clinics of North America 10:6, xi-xii
CrossRef565
Thomas R. Kinney, Russell E. Ware. (1996) THE ADOLESCENT WITH SICKLE CELL ANEMIA. Hematology/Oncology Clinics of North America 10:6, 1255-1264
CrossRef566
Oswaldo Castro. (1996) SYSTEMIC FAT EMBOLISM AND PULMONARY HYPERTENSION IN SICKLE CELL DISEASE. Hematology/Oncology Clinics of North America 10:6, 1289-1303
CrossRef567
Samuel Charache, Franca B. Barton, Richard D. Moore, Michael L. Terrin, Martin H. Steinberg, George J. Dover, Samir K. Ballas, Robert P. McMahon, Oswaldo Castro, Eugene P. Orringer. (1996) Hydroxyurea and Sickle Cell Anemia. Medicine 75:6, 300-326
CrossRef568
Martin H. Steinberg. (1996) Sickle Cell Disease: Present and Future Treatment. The American Journal of the Medical Sciences 312:4, 166-174
CrossRef569
Bradford D. Gessner, Steven M. Teutsch, Phaedra A. Shaffer. (1996) A cost-effectiveness evaluation of newborn hemoglobinopathy screening from the perspective of state health care systems. Early Human Development 45:3, 257-275
CrossRef570
Elizabeth N Anionwu. (1996) SICKLE CELL AND THALASSAEMIA: SOME PRIORITIES FOR NURSING RESEARCH. Journal of Advanced Nursing 23:5, 853-856
CrossRef571
Elizabeth A. Lowenthal, Alan Wells, Peter D. Emanuel, Rick Player, Josef T. Prchal. (1996) Sickle cell acute chest syndrome associated with parvovirus B19 infection: Case series and review. American Journal of Hematology 51:3, 207-213
CrossRef572
(1996) Incentive Spirometry in Sickle Cell Crisis. New England Journal of Medicine 334:2, 124-125
Full Text573
R. Grant Steen, James W. Langston, Wilburn E. Reddick, Robert Ogg, Gang Chen, Winfred C. Wang. (1996) Quantitative MR imaging of children with sickle cell disease: Striking T1 elevation in the thalamus. Journal of Magnetic Resonance Imaging 6:1, 226-234
CrossRef574
H.S. Juneja, E. Shulman, K. Reed, L.V. Mclntire, M. Natarajan. (1995) Pathophysiology and management of sickle cell pain crisis. The Lancet 346:8987, 1408-1411
CrossRef575
Griffin P. Rodgers, Eliezer A. Rachmilewitz. (1995) NOVEL TREATMENT OPTIONS IN THE SEVERE β-GLOBIN DISORDERS. British Journal of Haematology 91:2, 263-268
CrossRef576
Bellet, Paul S., Kalinyak, Karen A., Shukla, Rakesh, Gelfand, Michael J., Rucknagel, Donald L., . (1995) Incentive Spirometry to Prevent Acute Pulmonary Complications in Sickle Cell Diseases. New England Journal of Medicine 333:11, 699-703
Full Text577
A. FERSTER, F. CORAZZA, F. VERTONGEN, W. BUJAN, C. DEVALCK, P. FONDU, P. COCHAUX, M. LAMBERMONT, Z. KHALADJI, E. SARIBAN. (1995) Transplanted sickle-cell disease patients with autologous bone marrow recovery after graft failure develop increased levels of fetal haemoglobin which corrects disease severity. British Journal of Haematology 90:4, 804-808
CrossRef578
Vichinsky, Elliot P., Haberkern, Charles M., Neumayr, Lynne, Earles, Ann Noonan, Black, Dennis, Koshy, Mabel, Pegelow, Charles, Abboud, Miguel, Ohene-Frempong, Kwaku, Iyer, Rathi V., the Preoperative Transfusion in Sickle Cell Disease Study Group. (1995) A Comparison of Conservative and Aggressive Transfusion Regimens in the Perioperative Management of Sickle Cell Disease. New England Journal of Medicine 333:4, 206-214
Full Text579
HUGO J. WOLTERS, HUGO TEN CATE, LAMBERTUS L. M. THOMAS, DESIDERIUS P. M. BRANDIES, ABRAHAM ENDE, YVONNE HEIDEN, LODEWIJK W. STATIUS VAN EPS. (1995) Low-intensity oral anticoagulation in sickle-cell disease reverses the prethrombotic state: promises for treatment?. British Journal of Haematology 90:3, 715-717
CrossRef580
Sally C. Davies, P.O. Olatunji. (1995) Blood Transfusion in Sickle Cell Disease. Vox Sanguinis 68:3, 145-151
CrossRef581
Orah S. Platt. (1995) Sickle cell paths converge on hydroxyurea. Nature Medicine 1:4, 307-308
CrossRef582
M. H. Steinberg, H. Hsu, R. L. Nagel, P. F. Milner, J. G. Adams, L. Benjamin, S. Fryd, P. Gillette, J. Gilman, O. Josifovska, S. Hellman-Erlingsson, S. Safaya, L. Huey, R. F. Rieder. (1995) Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia. American Journal of Hematology 48:3, 175-181
CrossRef583
Susan P. Perrine, George H. Dover, Pratibha Daftari, Carol T. Walsh, YuXin Jin, Abbie Mays, Douglas V. Faller. (1994) Isobutyramide, an orally bioavailable butyrate analogue, stimulates fetal globin gene expression in vitro and in vivo. British Journal of Haematology 88:3, 555-561
CrossRef584
(1994) Mortality in Sickle Cell Disease. New England Journal of Medicine 331:15, 1022-1023
Full Text
- Letters
