Progressive Multifocal Leukoencephalopathy

Peter J. Weiss, M.D., and J. Kevin DeMarco, M.D.

N Engl J Med 1994; 330:1197April 28, 1994

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Figure 1 Progressive Multifocal Leukoencephalopathy.

Magnetic resonance images of the brain were obtained in a 40-year-old man with the acquired immunodeficiency syndrome who had a six-week history of decreased memory and visual impairment. The changes associated with progressive multifocal leukoencephalopathy are best seen on the T₂-weighted image (Panel A) as high-intensity abnormalities isolated in the white matter (arrows). A large, bilateral parieto-occipital lesion crosses the splenium of the corpus callosum (open arrows); a smaller frontal-lobe lesion is also present (solid arrow). On the T₁-weighted image (Panel B), the lesions appear as low-intensity abnormalities that are not enhanced with gadolinium, which helps differentiate progressive multifocal leukoencephalopathy from primary lymphoma of the central nervous system. Progressive neurologic deterioration occurred, and the patient died 14 weeks after the onset of symptoms.

Kim Eagle, M.D.

Peter J. Weiss, M.D.
J. Kevin DeMarco, M.D.
Naval Medical Center, San Diego, CA 92134

Citing Articles (1)

Citing Articles

1
N. J. Dalsgaard Hansen, C. Madsen, E. Stenager. (1996) Progressive multifocal leucoencephalopathy. The Italian Journal of Neurological Sciences 17:6, 393-399
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