Images in Clinical Medicine

Kim Eagle, M.D., Editor

Mycosis Fungoides

Tai-Yuen Wong, M.D., and Martin C. Mihm, Jr., M.D.

N Engl J Med 1993; 329:2001December 30, 1993

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Article

Figure 1 Mycosis Fungoides.

Mycosis fungoides is an epidermotropic variant of cutaneous T-cell lymphoma. The most notable histologic features in the plaque stage include a broad, band-like, cellular lymphoid infiltrate involving the densely fibrotic superficial dermis (arrows, Panel A). The lymphoid cells are small to medium in size and contain hyperconvoluted nuclei. The epidermis is involved when atypical lymphocytes form multiple nonspongiotic aggregates of Pautrier's microabscesses (arrows, Panel B). (Hematoxylin and eosin; Panel A, x60; Panel B, x240.).

Kim Eagle, M.D.

Tai-Yuen Wong, M.D.
Martin C. Mihm, Jr., M.D.
Massachusetts General Hospital, Boston, MA 02114

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