Images in Clinical Medicine

Kim Eagle, M.D., Editor

Zidovudine Myopathy

Patrick Chariot, M.D.

N Engl J Med 1993; 328:1675June 10, 1993

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Article

Figure 1 Zidovudine Myopathy.

A muscle-biopsy specimen from a 33-year-old man who had been treated with zidovudine for 24 months shows an accumulation of fine reddish granules in the sarcoplasm, corresponding to mitochondria in atrophic fibers (trichrome, x600). In addition to mitochondrial accumulation, the fibers show marked myofilamentous abnormalities that include myofibrillar loss and cytoplasmic-body formation (arrows).

Kim Eagle, M.D.

Patrick Chariot, M.D.
Hopital Henri-Mondor, 94000 Creteil, France

Citing Articles (3)

Citing Articles

1. 1

   Peter Greaves. 2012. Musculoskeletal System. , 157-206.
   CrossRef

2. 2

   NEIL J. NUSBAUM, PHILLIP E. JOSEPH. (1996) AZT Incorporation into Mitochondria: Study in a Human Myeloid Cell Line. DNA and Cell Biology 15:5, 363-366
   CrossRef

3. 3

   P. Chariot, F. Le Mague, F. J. Authier, D. Labes, F. Poron, R. Gherardi. (1995) Cytochrome c oxidase deficiency in zidovudine myopathy affects perifascicular muscle fibres and arterial smooth muscle cells. Neuropathology and Applied Neurobiology 21:6, 540-547
   CrossRef