Images in Clinical Medicine

Kim Eagle, M.D., Editor

Primary Biliary Cirrhosis

Marshall M. Kaplan, M.D.

N Engl J Med 1993; 328:1236April 29, 1993

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Article

Figure 1 Primary Biliary Cirrhosis.

Stage I lesions in primary biliary cirrhosis are seen in these slides, with typical destruction of small bile ducts by lymphocytes. In Panel A and Panel B, a small bile duct is surrounded and infiltrated by lymphocytes. In Panel C and Panel D, there is eccentric destruction of bile-duct cells. As the disease progresses, more bile ducts are destroyed, and in the late stages of the disease there is a characteristic paucity of bile ducts.

Kim Eagle, M.D.

Marshall M. Kaplan, M.D.
New England Medical Center, Boston, MA 02111