Images in Clinical Medicine

Kim Eagle, M.D., Editor

Membranous Glomerulonephritis

Edmund J. Lewis, M.D., and Melvin M. Schwartz, M.D.

N Engl J Med 1993; 328:481February 18, 1993

• Slide

Article

Figure 1 Membranous Glomerulonephritis.

A transmission electron micrograph (Panel A) shows a cross section of a glomerular capillary loop with the typical changes of membranous glomerulonephritis (x5300). Large, electron-dense deposits are visible on the outer aspect of the glomerular basement membrane, with interposition of basement-membrane material that forms “spikes.” A fluorescence photomicrograph (Panel B) reveals the IgG composition of these immune deposits within the glomerular capillary wall (x72).

Kim Eagle, M.D.

Edmund J. Lewis, M.D.
Melvin M. Schwartz, M.D.
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612