Original Article
Psychological Stress and Susceptibility to the Common Cold
N Engl J Med 1991; 325:606-612August 29, 1991
- Abstract
- Abstract
Background.
It is not known whether psychological stress suppresses host resistance to infection. To investigate this issue, we prospectively studied the relation between psychological stress and the frequency of documented clinical colds among subjects intentionally exposed to respiratory viruses.
Methods.
After completing questionnaires assessing degrees of psychological stress, 394 healthy subjects were given nasal drops containing one of five respiratory viruses (rhinovirus type 2, 9, or 14, respiratory syncytial virus, or coronavirus type 229E), and an additional 26 were given saline nasal drops. The subjects were then quarantined and monitored for the development of evidence of infection and symptoms. Clinical colds were defined as clinical symptoms in the presence of an infection verified by the isolation of virus or by an increase in the virus-specific antibody titer.
Results.
The rates of both respiratory infection (P<0.005) and clinical colds (P<0.02) increased in a dose-response manner with increases in the degree of psychological stress. Infection rates ranged from approximately 74 percent to approximately 90 percent, according to levels of psychological stress, and the incidence of clinical colds ranged from approximately 27 percent to 47 percent. These effects were not altered when we controlled for age, sex, education, allergic status, weight, the season, the number of subjects housed together, the infectious status of subjects sharing the same housing, and virus-specific antibody status at base line (before challenge). Moreover, the associations observed were similar for all five challenge viruses. Several potential stress—illness mediators, including smoking, alcohol consumption, exercise, diet, quality of sleep, white-cell counts, and total immunoglobulin levels, did not explain the association between stress and illness. Similarly, controls for personality variables (self-esteem, personal control, and introversion—extraversion) failed to alter our findings.
Conclusions.
Psychological stress was associated in a dose-response manner with an increased risk of acute infectious respiratory illness, and this risk was attributable to increased rates of infection rather than to an increased frequency of symptoms after infection. (N Engl J Med 1991; 325:606–12.)
Media in This Article
Figure 1
Observed Association between the Psychological-Stress Index and the Rate of Clinical Colds and the Association Adjusted fot Standard Contrai Variables.Figure 2
Observed Association between the Psychological-Stress Index and the Rate of Infection and the Association Adjusted for Standard Control Variables.Article Activity
- Article
STRESSFUL life events are commonly believed to suppress host resistance to infection. When demands imposed by events exceed a person's ability to cope, a psychological stress response composed of negative cognitive and emotional states is elicited.1 Psychological stress, in turn, is thought to influence immune function through autonomic nerves innervating lymphoid tissue2 , 3 or hormone-mediated alteration of immune cells.4 , 5 Stress may also alter immune responses through the adoption of coping behaviors such as increased smoking and alcohol consumption.6
There is substantial evidence that stressful life events and perceived stress are associated with changes in immune function.7 8 9 Although psychological stress is often described as suppressing immune response, the implications of stress-induced immune changes for susceptibility to disease have not been elucidated.10 , 11
There is some direct evidence from previous studies that psychological stress increases the risk of verified acute infectious respiratory illness.12 13 14 These studies, however, did not control for the possible effects of stressful events on exposure to infectious agents (as opposed to their effects on resistance) or provide evidence about other behavioral and biologic mechanisms through which stress might influence a person's susceptibility to infection. Moreover, the literature on this topic is not entirely consistent; several studies have failed to find a relation between stress and respiratory disease.15 , 16
We present data from a prospective study of the association between psychological stress and susceptibility to the common cold. Healthy persons were assessed for degree of stress and then experimentally exposed to one of five cold viruses (394 subjects) or placebo (26 subjects). The association between stress and the development of biologically verified clinical disease was examined with use of control for base-line (prechallenge) serologic status, the identity of the challenge virus, allergic status, weight, the season, the number of subjects housed together, the infectious status of any subjects sharing housing, and various demographic factors. In further analyses we tested the possibility that a relation between stress and susceptibility to illness could be attributed to differences in health practices or differences in base-line white-cell counts or total antibody levels. A final analysis investigated the possibility that differences in personality rather than environmental factors causing stress might account for the association between stress and clinical colds.
Methods
The subjects were 154 men and 266 women who were residents of Britain and who volunteered to participate in trials at the Medical Research Council's Common Cold Unit (CCU) in Salisbury. All reported on their applications that they had no chronic or acute illness and were taking no regular medication; all were judged to be in good health after clinical and laboratory examination on their arrival at the unit. Pregnant women were excluded. The subjects' ages ranged from 18 to 54 years (mean [±SD], 33.6±10.6). Sixty-three percent of the subjects were women. Twenty-two percent had not completed their secondary education, 51 percent had completed secondary school but did not attend a university, and 27 percent had spent at least one year at a university. The subjects were reimbursed for their travel expenses and received free meals and accommodations during the study. The trial was approved by the Harrow District Ethical Committee, and informed consent was obtained from each subject after the nature and possible consequences of the study were fully explained.
Procedures
During their first two days at the CCU, the subjects underwent a thorough medical examination, completed a series of questionnaires related to behavior, psychological stress, personality, and health practices and had blood drawn for immune assessments and measurement of cotinine (a biochemical indicator of smoking) in serum. Subsequently, the subjects were given nasal drops containing a low infectious dose of one of five respiratory viruses — rhinovirus type 2 (n = 86), type 9 (n = 122), or type 14 (n = 92), respiratory syncytial virus (n = 40), or coronavirus type 229E (n = 54) — or saline drops (n = 26). The viral doses were intended to resemble those common in person-to-person transmission and to result in illness rates between 20 and 60 percent. For two days before and seven days after the viral challenge, the subjects were quarantined in large apartments (alone or with one or two others). Starting two days before the viral challenge and continuing through six days after the challenge, each subject was examined daily by a clinician who used a standard checklist of respiratory signs and symptoms.17 Examples of items on the checklist are sneezing, watering of the eyes, nasal stuffiness, nasal obstruction, postnasal discharge, sinus pain, sore throat, hoarseness, cough, and sputum. The number of facial tissues used daily by each subject was also counted. Approximately 28 days after the challenge, a second serum sample was collected by the subjects' own physicians and shipped to the CCU for serologic testing. All the investigators were blinded to the subjects' psychological status and to whether they had received virus or saline drops.
Psychological-Stress Index
Three measures of psychological stress were used: the number of major stressful life events judged by the subject as having had a negative impact on his or her psychological state in the past year, the degree to which the subject perceived that current demands exceeded his or her ability to cope, and an index of current negative affect. The list of major stressful life events contained events that might have occurred in the life of the subject (41 items) or those of others close to the subject (26 items). The events were taken from the List of Recent Experiences compiled by Henderson et al.18 and were chosen because of their potential negative impact and their relatively high frequency in population studies. The score on this life-events scale was the number of events during the previous 12 months that the subject reported as having had a negative impact on his or her life. The 10-item Perceived Stress Scale19 was used to assess the degree to which situations in life were perceived as stressful (reliability, α = 0.85).20 Items on the Perceived Stress Scale were designed to measure the degree to which the subjects felt their lives were unpredictable, uncontrollable, and overwhelming. Finally, the negative-affect scale included 15 items from Zevon and Tellegen's list of negative emotions21: "distressed," "nervous," "sad," "angry," "dissatisfied with self," "calm" (scored negatively), "guilty," "scared," "angry at yourself," "upset," "irritated," "depressed," "hostile," "shaky," and "content" (scored negatively). Each subject was asked to indicate the intensity of each feeling during the past week on a five-point scale ranging from 0 to 4 (reliability, α = 0.84).
All three stress scales formed a single principal component with loadings of 0.66, 0.86, and 0.86, providing evidence that the scales measured a common underlying concept.22 An index combining the three measures was therefore used as an indicator of the degree of psychological stress experienced by the subjects (stress index). Because life events were not distributed normally, an index based on normalized scores was not appropriate. Instead, the index was created by calculating the quartiles for each scale and summing the quartile ranks for each subject (assigning a value of 1 for the lowest quartile and 4 for the highest); the resulting stress index ranged from 3 to 12. The quartiles divided the subjects into groups with the values 0, 1 through 2, 3 through 4, and 5 through 14 for the life-events scale; 0 through 10, 11 through 14, 15 through 18, and 19 through 33 for the Perceived Stress Scale; and 0 through 7, 8 through 13, 14 through 20, and 21 through 49 for the negative-affect scale. The index scores were approximately normally distributed. In all cases, a higher score indicated a greater degree of stress.
Viral Isolates and Virus–Specific Antibody Levels
Nasal-wash samples were collected for viral isolation before inoculation and on days 2 through 6 after inoculation. They were mixed with broth and stored in aliquots at -70°C. Rhinoviruses were detected in O-HeLa cells, respiratory syncytial virus in HEp-2 cells, and coronavirus in the C-16 strain of continuous human fibroblast cells. When a characteristic cytopathic effect was observed in the tissue culture, fluids were transferred to further cultures and tests were performed to identify the virus. The identity of rhinoviruses and coronaviruses was confirmed by neutralization tests with specific rabbit immune serum, and that of respiratory syncytial virus by immunofluorescent staining of culture cells.
Levels of neutralizing antibodies and of specific antiviral IgA and IgG were determined before and 28 days after the challenge. Neutralizing antibodies (for rhinoviruses only) were determined by neutralizing tests with homologous virus.23 The results were recorded as the highest dilution showing neutralization, and a fourfold increase was regarded as significant. Suitable neutralizing tests were not available for respiratory syncytial virus and coronavirus.
Specific IgA and IgG levels for rhinoviruses,24 coronavirus,25 and respiratory syncytial virus25 were determined by enzyme-linked immunosorbent assay. This test detects antibody that correlates with neutralization titers, is associated with resistance to infection, and increases in response to infection.23
Infections and Clinical Colds
A subject was deemed infected if virus was isolated after the challenge or if there was a significant increase over base-line levels in the virus–specific serum antibody titer (i.e., a fourfold increase in neutralizing antibody [rhinoviruses]) or an increase in the IgG or IgA level of more than 2 SD above the mean for the unchallenged subjects (all viruses). Eighty-two percent of the subjects who received virus (325 subjects) were infected. Five subjects who received saline (19 percent) were also infected. We attributed infections in the saline (placebo) group to transmission of virus from infected subjects to others housed in the same apartments. Control for person-to-person transmission was included in the data analysis.
At the end of the trial, a physician judged the severity of each subject's cold on a scale ranging from none (0) to severe (4). Ratings of mild cold (2) or more were considered positive clinical diagnoses. The subjects also rated the severity of their colds on the same scale. The clinical diagnosis was in agreement with the subject's rating in 94 percent of the cases. The subjects were classified as having clinical colds if they both had evidence of infection and were given the diagnosis of a clinical cold. Of the 394 subjects who received virus, 38 percent (148) had clinical colds. None of the 26 subjects who received saline had a cold.
Seven subjects with positive clinical diagnoses but no indication of infection were excluded from the sample because we assumed the illness was caused by exposure to another virus before the trial. Analyses including these seven subjects resulted in conclusions identical to those reported here.
Standard Control Variables
We used a series of control variables that might provide alternative explanations for the relation between stress and illness. These include serologic status for the experimental virus before the challenge, age, sex, education, allergic status, weight, the season, the number of subjects housed together, whether a subject housed in the same apartment was infected, and the identity of the challenge virus.
Serologic status was defined as positive when a subject had a base-line neutralizing antibody titer above 2 for rhinoviruses and a base-line antibody level greater than the sample median for coronavirus or respiratory syncytial virus. Forty-three percent of the subjects were seropositive before the challenge: 55 percent for rhinovirus type 2, 48 percent for rhinovirus type 9, 20 percent for rhinovirus type 14, 50 percent for respiratory syncytial virus, and 50 percent for coronavirus.
Because age was not normally distributed, it was scored categorically as above or below the median: 18 through 33 years or 34 through 54 years. Education levels were classified on an 8-point scale ranging from no schooling (0) to a doctoral degree (8), as reported by the subjects. Allergic status was determined on the basis of the subjects' answers to questions about allergies to food, drugs, or other allergens. Subjects who reported any allergy were defined as allergic. A ponderal index (the weight divided by the cube of the height) was used to control for subjects' weight. We used the number of hours of daylight on the first day of the trial as a continuous measure of the season. The number of daylight hours is correlated (r = 0.80, P<0.001) with the average temperature on the same day. Control for the possibility that person-to-person transmission rather than viral challenge might be responsible for infections or clinical colds was also included. Because person-to-person transmission would have been possible only if a subject sharing the same housing had been infected by the viral challenge, a control variable indicated whether or not any subject sharing the same housing was infected. Finally, the challenge virus was a categorical variable indicating the experimental virus to which a subject was exposed.
Measures of Health Practice
Health practices — including smoking, alcohol consumption, exercise, quality of sleep, and dietary practices — were assessed as possible factors linking stress and susceptibility. Cotinine measured in serum by gas chromatography was used as a biochemical indicator of the smoking level because it provided an objective measure of nicotine intake that was not subject to reporting bias.26 , 27 We used the base-10 logarithm of the average of the two cotinine measures (before and 28 days after challenge) as an indicator of the level of smoking. (The correlation between the two measures was 0.95 [P<0.001, n = 348].) The correlation between log10 average cotinine level and the log10 number of cigarettes reported as smoked per day was 0.96 (P<0.001, n = 372).
The remaining health practices were assessed by questionnaire before the viral challenge. The average number of alcoholic drinks per day was calculated on the basis of separate estimates of weekday and weekend drinking. A half-pint, bottle, or can of beer, a glass of wine, and a shot of whiskey contain approximately equal amounts of alcohol, and each was treated as a single drink. The exercise index included items on the frequency of walking, running, jogging, swimming, aerobic exercise, and work around the house. The quality-of-sleep index included items on feeling rested, difficulty falling asleep, and awakening early; and the dietary-habit index was made up of items designed to assess concern with a healthful diet and included the frequency of eating breakfast, fruits, and vegetables.
White-Cell Counts and Total Immunoglobulin Levels
White-cell counts and total immunoglobulin levels were assessed as possible factors linking psychological stress and susceptibility to illness. Assays were performed in blood samples collected before the viral challenge. White cells were counted with an automatic cell counter, and differential counts (lymphocytes, monocytes, and neutrophils) were calculated from 200 cells in a stained film. Total serum and nasal-wash IgA and IgE levels and total nasal-wash protein levels were assessed by enzyme-linked immunosorbent assay.25 We used the base-10 logarithm of each differential count and immunoglobulin measurement.
Measures of Personality
Because the degree of psychological stress might reflect stable personality styles rather than responses to environmental factors causing stress, two personality characteristics closely associated with stress — self-esteem and personal control (the expectation that one can control events) — were assessed before the viral challenge. Self-esteem was measured with the self-regard and social-confidence subscales of the Feelings of Inadequacy Scale28 (reliability, α = 0.89) and personal control with the personal-efficacy and interpersonal-control subscales of the Spheres of Control Scale29 (reliability, α = 0.76). A third personality characteristic, the degree of relative introversion or extraversion, was also assessed because some evidence had suggested that introverts were at higher risk for infection.30 , 31 This characteristic was assessed with the Eysenck Personality Inventory32 (reliability, α = 0.80).
Statistical Analysis
The primary analysis tested whether psychological stress was associated with a higher incidence of clinical colds. Secondary analyses assessed the importance of the two components of the definition of a clinical cold, documented infection and symptoms, in accounting for the association between stress and clinical colds. Specifically, we determined whether the relation between stress and colds was attributable to an increase in infection or to an increase in diagnosed colds among infected persons. The subjects who received saline were not included in these analyses.
Logistic regression was used to predict categorical outcomes.33 We conducted a series of analyses. In the first stage, only the psychological-stress index was entered as a predictor. In the second, we entered the standard control variables in the initial step of the regression analysis and then tested whether there was a significant change in the log likelihood of a clinical cold when the stress index was added to the equation. Education, weight, the season, and the number of subjects sharing an apartment were entered as continuous variables, and the remainder of the standard controls as dummy (categorical) variables.33 Because the predictor (the stress-index score) was a continuous variable, we have reported raw regression coefficients (b) and their standard errors.33 To estimate the sizes of effects, we have also reported odds ratios and their 95 percent confidence intervals, derived from modified regression models in which the continuous stress-index score was replaced with a contrast between the subjects in the bottom and the top quartiles of the stress index. The odds ratio approximates how much more likely it was that the outcome (infection or clinical cold) would be present among those with the highest stress-index scores (top quartile group) than among those with the lowest scores (bottom quartile group).33
Additional analyses tested possible roles for immunity, health practices, and personality variables in mediating the relation between stress and clinical colds. In the first analysis, the possibility that white-cell counts, total antibody levels, or five different health practices operated as pathways through which psychological stress influenced the risk of having a clinical cold was assessed by entering these variables along with the standard control variables in the first step of the regression equation and then testing whether adding stress to the equation accounted for a significant change in the log likelihood of illness. In the second analysis, the possibility that the effects of stress might reflect differences in personality rather than reactions to environmental stress factors was assessed by adding first two personality variables associated with stress (self-esteem and personal control) and then another previously associated with susceptibility to infection (introversion—extraversion) to the set of control variables and testing for any additional contribution of stress. All the immune measures, health practices, and personality variables were entered as continuous variables.
Results
Preliminary analysis indicated that there were no statistically reliable interactions between the standard control variables and the stress index in predicting clinical colds (highest t = 1.62, P = 0.11).33 The relations we report between the stress index and colds were thus similar for the five viruses and for groups defined by serologic status, age, sex, allergic status, education, weight, the number of subjects sharing an apartment, whether another subject in the same housing was infected, and the season.
There were, however, main effects of three standard control variables — serologic status (P<0.001), the virus (P<0.001), and whether another subject in the same apartment was infected (P<0.02). The P value for the remaining variables was >0.20. Subjects who were seronegative at base line had more colds (49.3 percent) than those who were seropositive (22.2 percent). The incidence of colds was 61.1 percent for coronavirus, 42.4 percent for rhinovirus type 14, 37.5 percent for respiratory syncytial virus, 33.6 percent for rhinovirus type 9, and 23.3 percent for rhinovirus type 2. Finally, subjects sharing an apartment with an infected subject had more colds (40.9 percent) than those without an infected apartment mate (26.4 percent). Although they were associated with the development of clinical colds, none of these three variables was reliably associated with the stress index (highest F = 1.44, P<0.22).
As is apparent in Figure 1Figure 1
Observed Association between the Psychological-Stress Index and the Rate of Clinical Colds and the Association Adjusted fot Standard Contrai Variables., the rate of clinical colds increased in a dose–response manner with increases in the stress-index score (b [±SE] = 0.10±0.04, P<0.02, n = 394; odds ratio for the comparison of the highest and lowest quartile groups = 1.98 [95 percent confidence interval, 1.10 to 3.56]). Moreover, entering the standard control variables into the equation before the stress index (adjusted rates are shown in Fig. 1) did not alter this association (b = 0.10±0.05, P<0.04, n = 394; odds ratio = 2.16 [95 percent confidence interval, 1.11 to 4.23]).As is apparent in Figures 2Figure 2
Observed Association between the Psychological-Stress Index and the Rate of Infection and the Association Adjusted for Standard Control Variables., the rates of infection also increased with increases in the stress index (b = 0.15±0.05, P<0.005, n = 394; odds ratio for the comparison of the highest and lowest quartile groups = 3.45 [95 percent confidence interval, 1.51 to 7.87]). This relation was similarly unaltered by the inclusion of standard control variables in the equation (b = 0.17±0.06, P<0.004; odds ratio = 5.81 [95 percent confidence interval, 2.12 to 15.91]). The level of stress was not, however, reliably associated with the rate of clinical colds among infected persons (b = 0.07±0.04, P = 0.13; including the control variables: b = 0.06±0.05, P = 0.24, n = 325). Hence, the relation between stress and colds was primarily attributable to an increased rate of infections among subjects with higher stress-index scores, rather than to an increase in clinical colds among infected persons with higher stress scores.The similar effect of stress at the various levels of each standard control variable (i.e., the lack of interaction between stress and each control variable) has already been mentioned. Of special importance in interpreting this study is the fact that stress had the same effects in all the challenge-virus groups regardless of the infectious status of apartment mates or prechallenge serologic status. The consistent effect of stress among the five viruses is illustrated in Figures 3Figure 3
Subjects with Low Degrees of Psychological Stress (Index Values below the Median) and High Degrees of Stress (Values above the Median) Who Had Colds, According to Challenge-Virus Group. and 4Figure 4
Subjects with Low Degrees of Psychological Stress (Index Values below the Median) and High Degrees of Stress (Values above the Median) Who Were Infected, According to Challenge-Virus Group., which present the rates of colds and infection (adjusted for standard control variables) according to challenge virus for subjects below the median value of the stress index (low stress) and above the median (high stress). That the effects of stress were similar for all viruses suggests the biologic generality of the effect. Table 1Table 1
Rates of Infection and Colds among Subjects with High and Low Stress-Index Scores, According to Prechallenge Serologic Status and the Infectious Status of Apartment Mates.* presents similar data for base-line serologic status and the infectious status of subjects sharing the same apartment. The data on subjects housed together indicate that greater person-to-person transmission among subjects with higher stress-index scores cannot explain the association between stress and colds (such transmission was possible only if the subject had an infected apartment mate). Finally, consistency among groups defined by prechallenge serologic status suggests that if an immune mechanism is the mediator of the relation between stress and colds, it is a primary and not a secondary (immune-memory) mechanism.Additional analyses tested the possible roles of immunity, health practices, and personality variables in the relation between stress and clinical colds. In the first analysis, we assessed the possibility that measures of white-cell populations (differentials), total immunoglobulin levels, or health practices operate as pathways through which psychological stress is related to clinical illness. These variables were entered together, along with the standard controls, in the first step of a regression equation, with the stress index entered in the second step. The stress index continued to add to the predictive power of the equation even after the additional controls were entered (b = 0.14±0.05, P<0.01). Hence, none of these variables were responsible for the association between stress and illness in this study.
In the second analysis, we assessed the possibility that effects of stress might actually reflect differences in personality rather than reactions to environmental Stressors. Two personality variables associated with stress (self-esteem, r = -0.52, P<0.001; and sense of personal control, r = -0.25, P<0.001) and another previously associated with susceptibility to infection (introversion—extraversion, r with stress = -0.04, P = 0.46) were added to the first step of the regression (with standard controls, health practices, and immune controls), and the stress index was entered in the second step. The stress index continued to produce a unique contribution to the explanation of colds (b = 0.13±0.06, P<0.04). Thus, none of the personality characteristics we studied could account for the relation between stress and illness.
Discussion
Psychological stress was associated with an increased risk of acute infectious respiratory illness in a dose–response manner; this risk was attributable to increased rates of infection. Although there was some person-to-person transmission of virus in this study, the effect of stress on colds was independent of whether such transmission was possible (i.e., whether a subject shared housing with another infected subject). Moreover, the relation between stress and colds was similar for those with and without infected apartment mates. In short, the stress index was associated with host resistance and not with differential exposure to virus.
The relation between stress and colds also proved to be independent of a variety of health practices. If the increased risk of illness for subjects with higher stress-index scores was not due to associations between stress and exposure to virus or between stress and health practices, what accounts for this relation? Evidence from both human and animal studies indicates that stress modulates immunity.7 8 9 Although the immune measures assessed in this study (prechallenge white-cell counts and antibody levels) did not explain the relation between stress and colds, these are quantitative measures; qualitative (functional) measures of immunity were not assessed. Because the effects of stress were the same for both subjects who were seropositive at base line and those who were seronegative, an explanation of the association between stress and illness would need to focus on primary rather than secondary immune responses. Some examples of primary immune functions that could have a role in this association are endothelial or lymphocyte production of interferon, mucus production, and natural-killer-cell activity.34
The association between stress and clinical illness was limited (adjusted odds ratio = 2.16), and the detection of the effect required a large sample. The relation between stress and infection, however, is stronger (adjusted odds ratio = 5.81). Moreover, the consistency of the stress-illness relation among three very different viruses — rhinovirus, coronavirus, and respiratory syncytial virus (as well as among rhinovirus types) — was impressive. This observation suggests that stress is associated with the suppression of a general resistance process in the host, leaving persons susceptible to multiple infectious agents, or that stress is associated with the suppression of many different immune processes, with similar results.
Although psychological stress is conceptualized here as a response to environmental events, our measures may also reflect personality characteristics that are independent of environmental factors. However, self-esteem and personal control, two personality characteristics strongly associated with stress, did not account for the effect of stress in this study. Another personality characteristic previously found to predict susceptibility to infection, introversion—extraversion, similarly did not account for the effect of stress. Because the psychological stress index assesses negative cognitive and emotional states rather than environmental stress factors, however, it is possible that it reflects other, individual traits not controlled for in the current study.
The results of research on stress as a risk factor in verified infectious disease have been inconsistent.10 This inconsistency may be due to insensitive techniques for detecting a relatively small effect on clinical illness. Our data suggest that a relation between stress and susceptibility to illness may be best detected in studies that incorporate control for important demographic and biologic characteristics, reliable and broadly defined indexes of stress, controlled exposure to the infectious agent, and relatively large samples.
Supported by grants from the National Institute of Allergy and Infectious Diseases (AI23072) and the Office of Naval Research (N00014–88–K0063), by a Research Scientist Development Award to Dr. Cohen from the National Institute of Mental Health (MH00721), and by the Medical Research Council's Common Cold Unit, Salisbury, United Kingdom.
We are indebted to S. Bull, J. Greenhouse, M. Jarvis, H. Parry, M. Russell, M. Sargent, J. Schiarb, S. Trickett, the medical, nursing, and technical staff of the Common Cold Unit, and the volunteers for their contributions to the research; and to J. Cunnick, R. Dawes, D. Klahr, K. Kotovsky, K. Matthews, B. Rabin, and M. Scheier for comments on an earlier draft of the manuscript.
Source Information
From the Department of Psychology, Carnegie Mellon University, Pittsburgh (S.C.); the Medical Research Council Common Cold Unit, Salisbury, United Kingdom (D.A.J.T.); and the Health Psychology Research Unit, University of Wales College of Cardiff, Cardiff, United Kingdom (A.P.S.). Address reprint requests to Dr. Cohen at the Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213.
- References
References
1
Lazarus RS, Folkman S. Stress appraisal, and coping. New York: Springer, 1984.
2
Feiten
Web of Science | Medline3
Feiten
CrossRef | Web of Science | Medline4
Shavit
CrossRef | Web of Science | Medline5
Rabin
Web of Science | Medline6
Kiecolt-Glaser
CrossRef | Medline7
Ader R, ed. Psychoneuroimmunology. New York: Academic Press, 1981.
8
Caiabrese 9
Kiecolt-Glaser JK, Glaser R. Psychosocial factors, stress, disease, and immunity. In: Ader R, Feiten DL, Cohen N, eds. Psychoneuroimmunology. New York: Academic Press, 1991:849–67.
10
Cohen
CrossRef | Web of Science | Medline11
Laudenslager ML. Psychosocial stress and susceptibility to infectious disease. In: Kurstak E, Lipowski AJ, Morozov PV, eds. Viruses, immunity, and mental disorders. New York: Plenum Medical Books, 1987:391–402.
12
Graham
Web of Science | Medline13
Boyce
Web of Science | Medline14
Meyer
Web of Science | Medline15
Alexander
Medline16
Cluff
CrossRef | Web of Science | Medline17
Beare AS, Reed SE. The study of antiviral compounds in volunteers. In: Oxford JS, ed. Chemoprophyiaxis and virus infections. Vol. 2. Cleveland: CRC Press, 1977:27–55.
18
Henderson S, Byrne DG, Duncan-Jones P. Neurosis and the social environment. Sydney, Australia: Academic Press, 1981.
19
Cohen S, Williamson G. Perceived stress in a probability sample of the United States. In: Spacapan S, Oskamp S, eds. The social psychology of health. Newbury Park, Calif.: Sage, 1988:31–67.
20
Cronbach
CrossRef21
Zevon
CrossRef | Web of Science22
Afifi AA, Clark V. Computer-aided multivariate analysis. Belmont, Calif.: Lifetime Learning Publications, 1984.
23
Al Nakib W, Tyrrell DAJ. Picornviridae: rhinoviruses — common cold viruses. In: Lennette EM, Halonen P, Murphy FA, eds. Laboratory diagnosis of infectious diseases: principles and practice. Vol. 2. New York: Springer-Verlag, 1988:723–42.
24
Barclay
CrossRef | Web of Science | Medline25
Callow
CrossRef | Web of Science | Medline26
Feyerabend
CrossRef | Web of Science | Medline27
Jarvis
CrossRef | Web of Science | Medline28
Fleming
CrossRef | Web of Science29
Paulhus
CrossRef | Web of Science30
Totman
CrossRef | Web of Science | Medline31
Broadbent
CrossRef | Web of Science | Medline32
Eysenck HJ, Eysenck SBG. Manual of the Eysenck Personality Inventory. London: University of London Press, 1964.
33
Hosmer DW Jr, Lemeshow S. Applied logistic regression. New York: John Wiley, 1989.
34
Morahan PS, Murasko DM. Viral infections. In: Nelson DS, ed. Natural immunity in disease processes. New York: Academic Press. 1989:557–86.
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Jacqueline M. Bliley, Sarah K. Woodley. (2011) The effects of repeated handling and corticosterone treatment on behavior in an amphibian (Ocoee salamander: Desmognathus ocoee). Physiology & Behavior
CrossRef6
Catherine J. Albright, David J. Hall. (2011) An exercise in molecular epidemiology: Human rhinovirus prevalence and genetics. Biochemistry and Molecular Biology Education 39:6, 426-431
CrossRef7
Mary T. Caserta, Peter A. Wyman, Hongyue Wang, Jan Moynihan, Thomas G. O'Connor. (2011) Associations among depression, perceived self-efficacy, and immune function and health in preadolescent children. Development and Psychopathology 23:04, 1139-1147
CrossRef8
Kumi Saito-Nakaya, Pernille E. Bidstrup, Naoki Nakaya, Kirsten Frederiksen, Susanne O. Dalton, Yosuke Uchitomi, Pia Verkasalo, Markku Koskenvuo, Eero Pukkala, Jaakko Kaprio, Christoffer Johansen. (2011) Stress and survival after cancer: A prospective study of a Finnish population-based cohort. Cancer Epidemiology
CrossRef9
Anna C. Phillips. (2011) Psychosocial Influences on Vaccine Responses. Social and Personality Psychology Compass 5:9, 621-633
CrossRef10
Hwan-Cheol Kim, Shin-Goo Park, Jong-Han Leem, Dal-Young Jung, Sang-Hee Hwang. (2011) Depressive symptoms as a risk factor for the common cold among employees: A 4-month follow-up study. Journal of Psychosomatic Research 71:3, 194-196
CrossRef11
Naoki Kondo, Yuki Suda, Atsuhito Nakao, Kyoko Oh-Oka, Kohta Suzuki, Kayoko Ishimaru, Miri Sato, Taichiro Tanaka, Akiko Nagai, Zentaro Yamagata. (2011) Maternal psychosocial factors determining the concentrations of transforming growth factor-beta in breast milk. Pediatric Allergy and Immunologyno-no
CrossRef12
Rena L. Repetti, Theodore F. Robles, Bridget Reynolds. (2011) Allostatic processes in the family. Development and Psychopathology 23:03, 921-938
CrossRef13
Byung-Jin Kim, Kay Kayembe, Jerry W. Simecka, Mark Pulse, Harlan P. Jones. (2011) Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection. Journal of Neuroimmunology 237:1-2, 57-65
CrossRef14
Adam D. Harper Smith, Sarah L. Coakley, Mark D. Ward, Andrew W. Macfarlane, Peter S. Friedmann, Neil P. Walsh. (2011) Exercise-induced stress inhibits both the induction and elicitation phases of in vivo T-cell-mediated immune responses in humans. Brain, Behavior, and Immunity 25:6, 1136-1142
CrossRef15
Andrea Danese, Bruce S. McEwen. (2011) Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior
CrossRef16
Hiren Pokharna, Anne Y. Chen. 2011. The Hospital and Ambulatory Care Environment. , 1-21.
CrossRef17
S.O. Reber. (2011) Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis. Psychoneuroendocrinology
CrossRef18
Nete Munk Nielsen, Anne Vinkel Hansen, Jacob Simonsen, Anders Hviid. (2011) Stressful life events in childhood and risk of infectious disease hospitalization. European Journal of Pediatrics
CrossRef19
Meenu Singh, Rashmi Ranjan Das. (2011) Clinical potential of zinc in prophylaxis of the common cold. Expert Review of Respiratory Medicine 5:3, 301-303
CrossRef20
Luke W. Hyde, Adam Gorka, Stephen B. Manuck, Ahmad R. Hariri. (2011) Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety. Neuropsychologia 49:4, 651-656
CrossRef21
Rigoberto Oros-Pantoja, Adriana Jarillo-Luna, Víctor Rivera-Aguilar, Luvia Enid Sánchez-Torres, Marycarmen Godinez-Victoria, Rafael Campos-Rodríguez. (2011) Effects of restraint stress on NALT structure and nasal IgA levels. Immunology Letters 135:1-2, 78-87
CrossRef22
Sine Skovbjerg, Alice Rasmussen, Robert Zachariae, Lone Schmidt, Rikke Lund, Jesper Elberling. (2011) The association between idiopathic environmental intolerance and psychological distress, and the influence of social support and recent major life events. Environmental Health and Preventive Medicine
CrossRef23
Felicia A. Rabito, John Carlson, Elizabeth W. Holt, Shahed Iqbal, Mark A. James. (2011) Cockroach exposure independent of sensitization status and association with hospitalizations for asthma in inner-city children. Annals of Allergy, Asthma & Immunology 106:2, 103-109
CrossRef24
Ebenezer Satyaraj. (2011) Emerging Paradigms in Immunonutrition. Topics in Companion Animal Medicine 26:1, 25-32
CrossRef25
S.- G. Park, H.- C. Kim, J.- Y. Min, S. H. Hwang, Y.- S. Park, K.- B. Min. (2011) A prospective study of work stressors and the common cold. Occupational Medicine 61:1, 53-56
CrossRef26
Marilee Coriell, Nancy E. Adler. 2011. Social Ordering and Health. .
CrossRef27
Felix K. Gmünder, Augusto Cogoli. 2011. Effect of Spaceflight on Lymphocyte Function and Immunity. .
CrossRef28
Andrew H. Miller, Bradley D. Pearce, Melanie C. Ruzek, Christine A. Biron. 2011. Interactions Between the Hypothalamic-Pituitary-Adrenal Axis and Immune System During Viral Infection: Pathways for Environmental Effects on Disease Expression. .
CrossRef29
Eduardo A. Undurraga, Colleen Nyberg, Dan T. A. Eisenberg, Oyunbileg Magvanjav, Victoria Reyes-García, Tomás Huanca, William R. Leonard, Thomas W. McDade, Susan Tanner, Vincent Vadez, , Ricardo Godoy. (2010) Individual Wealth Rank, Community Wealth Inequality, and Self-Reported Adult Poor Health: A Test of Hypotheses with Panel Data (2002-2006) from Native Amazonians, Bolivia. Medical Anthropology Quarterly 24:4, 522-548
CrossRef30
M. P. Buman, E. B. Hekler, W. L. Haskell, L. Pruitt, T. L. Conway, K. L. Cain, J. F. Sallis, B. E. Saelens, L. D. Frank, A. C. King. (2010) Objective Light-Intensity Physical Activity Associations With Rated Health in Older Adults. American Journal of Epidemiology 172:10, 1155-1165
CrossRef31
Tanja Adam, Imke Schamarek, Elizabeth A. Springer, Peter J. Havel, Elissa E. Epel. (2010) Adiponectin and negative mood in healthy premenopausal and postmenopausal women. Hormones and Behavior 58:5, 699-704
CrossRef32
Dominic Schmidt, Stefan O. Reber, Catherine Botteron, Thomas Barth, Daniel Peterlik, Nicole Uschold, Daniela N. Männel, Anja Lechner. (2010) Chronic psychosocial stress promotes systemic immune activation and the development of inflammatory Th cell responses. Brain, Behavior, and Immunity 24:7, 1097-1104
CrossRef33
Yori Gidron, Peter Hall, Keith A. Wesnes, Romola S. Bucks. (2010) Does a neuropsychological index of hemispheric lateralization predict onset of upper respiratory tract infectious symptoms?. British Journal of Health Psychology 15:3, 469-477
CrossRef34
G. M. Slavich, B. M. Way, N. I. Eisenberger, S. E. Taylor. (2010) Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proceedings of the National Academy of Sciences 107:33, 14817-14822
CrossRef35
Grant Benham. (2010) Sleep: an important factor in stress-health models. Stress and Health 26:3, 204-214
CrossRef36
Molly J. Dickens, David J. Delehanty, L. Michael Romero. (2010) Stress: An inevitable component of animal translocation. Biological Conservation 143:6, 1329-1341
CrossRef37
Margaret Kelaher, Deborah J. Warr, Peter Feldman, Theonie Tacticos. (2010) Living in ‘Birdsville’: Exploring the impact of neighbourhood stigma on health. Health & Place 16:2, 381-388
CrossRef38
Juan P. Wisnivesky, Jessica Lorenzo, Jonathan M. Feldman, Howard Leventhal, Ethan A. Halm. (2010) The Relationship between Perceived Stress and Morbidity among Adult Inner-City Asthmatics. Journal of Asthma 47:1, 100-104
CrossRef39
Firdaus S. Dhabhar, Alison N. Saul, Christine Daugherty, Tyson H. Holmes, Donna M. Bouley, Tatiana M. Oberyszyn. (2010) Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma. Brain, Behavior, and Immunity 24:1, 127-137
CrossRef40
G. HALL, L. McDONALD, S. E. MAJOWICZ, E. SCALLAN, M. KIRK, P. SOCKETT, F. J. ANGULO. (2010) Respiratory symptoms and the case definition of gastroenteritis: an international analysis of the potential impact on burden estimates. Epidemiology and Infection 138:01, 117
CrossRef41
Robert W. Luebke, Celine A. Beamer, Christal Bowman, Jamie DeWitt, Kymberly Gowdy, Victor J. Johnson, David M. Shepherd, Dori M. Germolec. 2009. Immunotoxicology. .
CrossRef42
Andrew Paul Smith. (2009) Chewing gum, stress and health. Stress and Health 25:5, 445-451
CrossRef43
Renée-Louise Franche, Colette N. Severin, Hyunmi Lee, Sheilah Hogg-Johnson, C. Gail Hepburn, Marjan Vidmar, Ellen MacEachen. (2009) Perceived Justice of Compensation Process for Return-to-Work: Development and Validation of a Scale. Psychological Injury and Law 2:3-4, 225-237
CrossRef44
Takiko Sagara, Yoshiaki Hitomi, Yasuhiro Kambayashi, Yuri Hibino, Ichiyo Matsuzaki, Shinichiro Sasahara, Keiki Ogino, Kotaro Hatta, Hiroyuki Nakamura. (2009) Common risk factors for changes in body weight and psychological well-being in Japanese male middle-aged workers. Environmental Health and Preventive Medicine 14:6, 319-327
CrossRef45
Brian Cunniffe, Hywel Griffiths, Wayne Proctor, Ken P Jones, Julien S Baker, Bruce Davies. (2009) Illness Monitoring in Team Sports Using a Web-Based Training Diary. Clinical Journal of Sport Medicine 19:6, 476-481
CrossRef46
c. tana, y. umesaki, a. imaoka, t. handa, m. kanazawa, s. fukudo. (2009) Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterology & Motility
CrossRef47
Lisa M. Christian, Nathan T. Deichert, Jean-Philippe Gouin, Jennifer E. Graham, Janice K. Kiecolt-Glaser. 2009. Psychological Influences on Neuroendocrine and Immune Outcomes. .
CrossRef48
David Michelson. (2009) Depression: Body and Brain. Biological Psychiatry 66:5, 405-406
CrossRef49
Lori M. Ventura. (2009) Psychoneuroimmunology: application to ocular diseases. Journal of Ocular Biology, Diseases, and Informatics 2:3, 109-118
CrossRef50
S.M.S. Ebbesen, R. Zachariae, M.Y. Mehlsen, D. Thomsen, A. Hojgaard, L. Ottosen, T. Petersen, H.J. Ingerslev. (2009) Stressful life events are associated with a poor in-vitro fertilization (IVF) outcome: a prospective study. Human Reproduction 24:9, 2173-2182
CrossRef51
Charles R. Powell, Karl J. Kreder. (2009) Effects of stress on male voiding function. Current Bladder Dysfunction Reports 4:3, 171-175
CrossRef52
María León-Sanromà, Enric Aragonés Benaiges, Daniel Eichelbaum Sánchez, Pablo Pascual Pascual. (2009) Medicina de familia y salud mental. Atención Primaria 41:8, 427-428
CrossRef53
Andrew J. Steelman, Dana D. Dean, Colin R. Young, Roger Smith, Thomas W. Prentice, Mary W. Meagher, C. Jane R. Welsh. (2009) Restraint stress modulates virus specific adaptive immunity during acute Theiler’s virus infection. Brain, Behavior, and Immunity 23:6, 830-843
CrossRef54
Lori M. Ventura. (2009) Psychoneuroimmunology: application to ocular diseases. Journal of Ocular Biology, Diseases, and Informatics 2:2, 84-93
CrossRef55
Susan Faulkner, Andrew Smith. (2009) A prospective diary study of the role of psychological stress and negative mood in the recurrence of herpes simplex virus (HSV1). Stress and Health 25:2, 179-187
CrossRef56
Oleg Eremin, Mary B. Walker, Edna Simpson, Steven D. Heys, Antoine K. Ah-See, Andrew W. Hutcheon, Keith N. Ogston, Tarun K. Sarkar, Ashok Segar, Leslie G. Walker. (2009) Immuno-modulatory effects of relaxation training and guided imagery in women with locally advanced breast cancer undergoing multimodality therapy: A randomised controlled trial. The Breast 18:1, 17-25
CrossRef57
Nancy Sohler, Erica Lubetkin, Joel Levy, Christine Soghomonian, Arie Rimmerman. (2009) Factors Associated with Obesity and Coronary Heart Disease in People with Intellectual Disabilities. Social Work in Health Care 48:1, 76-89
CrossRef58
Gregory Miller, Edith Chen, Steve W. Cole. (2009) Health Psychology: Developing Biologically Plausible Models Linking the Social World and Physical Health. Annual Review of Psychology 60:1, 501-524
CrossRef59
2008. References. , 253-296.
CrossRef60
Gregory E. Miller, Edith Chen, Jasmen Sze, Teresa Marin, Jesusa M.G. Arevalo, Richard Doll, Roy Ma, Steve W. Cole. (2008) A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling. Biological Psychiatry 64:4, 266-272
CrossRef61
Tracey J. Woodruff, Lauren Zeise, Daniel A. Axelrad, Kathryn Z. Guyton, Sarah Janssen, Mark Miller, Gregory G. Miller, Jackie M. Schwartz, George Alexeeff, Henry Anderson, Linda Birnbaum, Frederic Bois, Vincent James Cogliano, Kevin Crofton, Susan Y. Euling, Paul M.D. Foster, Dori R. Germolec, Earl Gray, Dale B. Hattis, Amy D. Kyle, Robert W. Luebke, Michael I. Luster, Chris Portier, Deborah C. Rice, Gina Solomon, John Vandenberg, R. Thomas Zoeller. (2008) Meeting Report: Moving Upstream—Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making. Environmental Health Perspectives 116:11, 1568-1575
CrossRef62
Maria Dietrich, Katherine Verdolini Abbott, Jackie Gartner-Schmidt, Clark A. Rosen. (2008) The Frequency of Perceived Stress, Anxiety, and Depression in Patients with Common Pathologies Affecting Voice. Journal of Voice 22:4, 472-488
CrossRef63
Robert F. Anda, David W. Brown, Shanta R. Dube, J. Douglas Bremner, Vincent J. Felitti, Wayne H. Giles. (2008) Adverse Childhood Experiences and Chronic Obstructive Pulmonary Disease in Adults. American Journal of Preventive Medicine 34:5, 396-403
CrossRef64
Lisa Katzer, Alison J. Bradshaw, Caroline C. Horwath, Andrew R. Gray, Sue O'Brien, Janine Joyce. (2008) Evaluation of a “Nondieting” Stress Reduction Program for Overweight Women: A Randomized Trial. American Journal of Health Promotion 22:4, 264-274
CrossRef65
Jill Littrell. (2008) The Mind-Body Connection. Social Work in Health Care 46:4, 17-37
CrossRef66
Carolyn Y. Fang, Suzanne M. Miller, Dana H. Bovbjerg, Cynthia Bergman, Mitchell I. Edelson, Norman G. Rosenblum, Betsy A. Bove, Andrew K. Godwin, Donald E. Campbell, Steven D. Douglas. (2008) Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia. Annals of Behavioral Medicine
CrossRef67
Paula K. Lorgelly, Joanne Lindley. (2008) What is the relationship between income inequality and health? Evidence from the BHPS. Health Economics 17:2, 249-265
CrossRef68
Thierry Janssen. (2008) Counselling of the Prostate Cancer Patient as a Whole Person. European Urology Supplements 7:1, 29-34
CrossRef69
Susan Faulkner, Andrew Smith. (2008) A longitudinal study of the relationship between psychological distress and recurrence of upper respiratory tract infections in chronic fatigue syndrome. British Journal of Health Psychology 13:1, 177-186
CrossRef70
M. Innes Asher, Cameron C. Grant. 2008. Infections of the Upper Respiratory Tract. , 453-480.
CrossRef71
Ilia J. Elenkov. (2008) Neurohormonal-cytokine interactions: Implications for inflammation, common human diseases and well-being. Neurochemistry International 52:1-2, 40-51
CrossRef72
Francisco Tausk, Ilia Elenkov, Jan Moynihan. (2008) Psychoneuroimmunology. Dermatologic Therapy 21:1, 22-31
CrossRef73
Lindsay St. Claire, Alex Clift, Laura Dumbelton. (2008) How do i know what i feel? Evidence for the role of self-categorisation in symptom perceptions. European Journal of Social Psychology 38:1, 173-186
CrossRef74
Kyla A. Leon, Amanda D. Hyre, Danielle Ompad, Karen B. DeSalvo, Paul Muntner. (2007) Perceived stress among a workforce 6 months following hurricane Katrina. Social Psychiatry and Psychiatric Epidemiology 42:12, 1005-1011
CrossRef75
Palok Aich, Shakiba Jalal, Carly Czuba, Gabrielle Schatte, Katie Herzog, Douglas J.H. Olson, Andrew R.S. Ross, Andy A. Potter, Lorne A. Babiuk, Philip Griebel. (2007) Comparative Approaches to the Investigation of Responses to Stress and Viral Infection in Cattle. OMICS: A Journal of Integrative Biology 11:4, 413-434
CrossRef76
Margaret E. Kemeny, Manfred Schedlowski. (2007) Understanding the interaction between psychosocial stress and immune-related diseases: A stepwise progression. Brain, Behavior, and Immunity 21:8, 1009-1018
CrossRef77
Edith Chen, Gregory E. Miller. (2007) Stress and inflammation in exacerbations of asthma. Brain, Behavior, and Immunity 21:8, 993-999
CrossRef78
Norma C. Ware. 2007. Society, Mind and Body in Chronic Fatigue Syndrome: An Anthropological View. , 62-83.
CrossRef79
Simon Wessely. 2007. The Neuropsychiatry of Chronic Fatigue Syndrome. , 212-237.
CrossRef80
Jill E. MacLaren, Zeev N. Kain. (2007) Perioperative biopsychosocial research: the future is here. Journal of Clinical Anesthesia 19:6, 410-412
CrossRef81
E. Kosor Krnic, A. Gagro, D. Kozaric-Kovacic, M. Vilibic, M. Grubisic-Ilic, V. Folnegovic-Smalc, V. Drazenovic, E. Cecuk-Jelicic, I. Gjenero-Margan, I. Kuzman, T. Jeren, A. Sabioncello, V. Kerhin-Brkljacic, B. Kaic, A. Markotic, K. Gotovac, S. Rabatic, G. Mlinaric-Galinovic, D. Dekaris. (2007) Outcome of influenza vaccination in combat-related post-traumatic stress disorder (PTSD) patients. Clinical & Experimental Immunology 149:2, 303-310
CrossRef82
Christopher F. Sharpley, David R. H. Christie. (2007) ‘How I was then and how I am now’: current and retrospective self-reports of anxiety and depression in Australian women with breast cancer. Psycho-Oncology 16:8, 752-762
CrossRef83
Peter C. Winwood, Arnold B. Bakker, Anthony H. Winefield. (2007) An Investigation of the Role of Non???Work-Time Behavior in Buffering the Effects of Work Strain. Journal of Occupational and Environmental Medicine 49:8, 862-871
CrossRef84
Christopher F. Sharpley, David R. H. Christie. (2007) An analysis of the psychometric profile and frequency of anxiety and depression in Australian men with prostate cancer. Psycho-Oncology 16:7, 660-667
CrossRef85
Gilbert C. Gee, Michael S. Spencer, Juan Chen, David Takeuchi. (2007) A Nationwide Study of Discrimination and Chronic Health Conditions Among Asian Americans. American Journal of Public Health 97:7, 1275-1282
CrossRef86
K Jeon, C.-I. Kang, C.-H. Yoon, D.-J. Lee, C.-H. Kim, Y.-S. Chung, C. Kang, C.-M. Choi. (2007) High isolation rate of adenovirus serotype 7 from South Korean military recruits with mild acute respiratory disease. European Journal of Clinical Microbiology & Infectious Diseases 26:7, 481-483
CrossRef87
Bum-Soo Hahn, Ik-Soo Jeon, Young-Jae Jung, Jong-Bum Kim, Jong-Suk Park, Sun-Hwa Ha, Kyung-Hwan Kim, Hyeong-Mi Kim, Joo-Sung Yang, Yong-Hwan Kim. (2007) Expression of hemagglutinin-neuraminidase protein of Newcastle disease virus in transgenic tobacco. Plant Biotechnology Reports 1:2, 85-92
CrossRef88
G. C. Gee, J. Delva, D. T. Takeuchi. (2007) Relationships Between Self-Reported Unfair Treatment and Prescription Medication Use, Illicit Drug Use, and Alcohol Dependence Among Filipino Americans. American Journal of Public Health 97:5, 933-940
CrossRef89
Hans Gustav Thyregod, Michael C. Rowbotham, Michelle Peters, Jessica Possehn, Marlene Berro, Karin Lottrup Petersen. (2007) Natural history of pain following herpes zoster. Pain 128:1-2, 148-156
CrossRef90
Jennifer S. Lerner, Ronald E. Dahl, Ahmad R. Hariri, Shelley E. Taylor. (2007) Facial Expressions of Emotion Reveal Neuroendocrine and Cardiovascular Stress Responses. Biological Psychiatry 61:2, 253-260
CrossRef91
Loretta Vileikyte. (2007) Stress and wound healing. Clinics in Dermatology 25:1, 49-55
CrossRef92
Jonathan P. Godbout, Ronald Glaser. (2006) Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer. Journal of Neuroimmune Pharmacology 1:4, 421-427
CrossRef93
Jennifer F. Culhane, Virginia A. Rauh, Robert L. Goldenberg. (2006) Stress, bacterial vaginosis, and the role of immune processes. Current Infectious Disease Reports 8:6, 459-464
CrossRef94
Alicia Collado-Hidalgo, Caroline Sung, Steve Cole. (2006) Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication. Brain, Behavior, and Immunity 20:6, 552-563
CrossRef95
L.D. Devanur, J.R. Kerr. (2006) Chronic fatigue syndrome. Journal of Clinical Virology 37:3, 139-150
CrossRef96
Beenish Khan, Sheikh Fayaz Ahmad, Sarang Bani, Anpurna Kaul, K.A. Suri, N.K. Satti, M. Athar, G.N. Qazi. (2006) Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed mice. International Immunopharmacology 6:9, 1394-1403
CrossRef97
Douglas L. Miller, Christina Paxson. (2006) Relative income, race, and mortality. Journal of Health Economics 25:5, 979-1003
CrossRef98
K.-H. Schulz, S. Gold. (2006) Psychische Belastung, Immunfunktionen und Krankheitsentwicklungen Die psychoneuroimmunologische Perspektive. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 49:8, 759-772
CrossRef99
G. Dobos, N. Altner, S. Lange, F. Musial, J. Langhorst, A. Michalsen, A. Paul. (2006) Mind-Body Medicine als Bestandteil der Integrativen Medizin. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 49:8, 723-728
CrossRef100
Michael D. Robinson, Benjamin M. Wilkowski. (2006) Loving, Hating, Vacillating: Agreeableness, Implicit Self-Esteem, and Neurotic Conflict. Journal of Personality 74:4, 935-978
CrossRef101
P. Muennig, E. Lubetkin, H. Jia, P. Franks. (2006) Gender and the Burden of Disease Attributable to Obesity. American Journal of Public Health 96:9, 1662-1668
CrossRef102
Rijk O.B. Gans. (2006) The Metabolic Syndrome, Depression, and Cardiovascular Disease: Interrelated Conditions that Share Pathophysiologic Mechanisms. Medical Clinics of North America 90:4, 573-591
CrossRef103
Tara McKee Cousineau, Jonathan Shedler. (2006) Predicting Physical Health. The Journal of Nervous and Mental Disease 194:6, 427-432
CrossRef104
2006. References. , 419-486.
CrossRef105
L. Hadany, T. Beker, I. Eshel, M. W Feldman. (2006) Why is stress so deadly? An evolutionary perspective. Proceedings of the Royal Society B: Biological Sciences 273:1588, 881-885
CrossRef106
Charles N. Bernstein, John R. Walker, Lesley A. Graff. (2006) On Studying the Connection Between Stress and IBD. The American Journal of Gastroenterology 101:4, 782-785
CrossRef107
Melissa A. Bray, Thomas J. Kehle, Heather L. Peck, Suzanne G. Margiano, Robin Dobson, Kate Peczynski, Kate Gardner, Lea A. Theodore, Jolie M. Alric. (2006) Written Emotional Expression as an Intervention for Asthma. Journal of Applied School Psychology 22:1, 141-165
CrossRef108
Anna C. Phillips, Douglas Carroll, Phil Evans, Jos A. Bosch, Angela Clow, Frank Hucklebridge, Geoff Der. (2006) Stressful life events are associated with low secretion rates of immunoglobulin A in saliva in the middle aged and elderly. Brain, Behavior, and Immunity 20:2, 191-197
CrossRef109
William J. Doyle, Deborah A. Gentile, Sheldon Cohen. (2006) Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure. Brain, Behavior, and Immunity 20:2, 175-181
CrossRef110
Tonja R. Nansel, Margaret A. Riggs, Kai-Fun Yu, William W. Andrews, Jane R. Schwebke, Mark A. Klebanoff. (2006) The association of psychosocial stress and bacterial vaginosis in a longitudinal cohort. American Journal of Obstetrics and Gynecology 194:2, 381-386
CrossRef111
Elizabeth R. Volkmann, Nicole Y. Weekes. (2006) Basal SIgA and cortisol levels predict stress-related health outcomes. Stress and Health 22:1, 11-23
CrossRef112
Christine Reynaert, Yves Libert, Denis Jacques, Nicolas Zdanowicz. (2006) Autour du corps souffrant : relation médecin-patient-entourage, trio infernal ou constructif ?. Cahiers critiques de thérapie familiale et de pratiques de réseaux 36:1, 103
CrossRef113
Paul Hewlett, Andrew Smith. (2006) Correlates of daily caffeine consumption. Appetite 46:1, 97-99
CrossRef114
Samuel Melamed, Arie Shirom, Sharon Toker, Shlomo Berliner, Itzhak Shapira. (2006) Burnout and Risk of Cardiovascular Disease: Evidence, Possible Causal Paths, and Promising Research Directions.. Psychological Bulletin 132:3, 327-353
CrossRef115
Olli-Pekka Alho. (2005) Viral infections and susceptibility to recurrent sinusitis. Current Allergy and Asthma Reports 5:6, 477-481
CrossRef116
Thomas W. McDade. (2005) THE ECOLOGIES OF HUMAN IMMUNE FUNCTION. Annual Review of Anthropology 34:1, 495-521
CrossRef117
Becca R. Levy, Lindsey M. Myers. (2005) Relationship between respiratory mortality and self-perceptions of aging. Psychology & Health 20:5, 553-564
CrossRef118
Andrew J. Shepherd, James E. G. Downing, Jaleel A. Miyan. (2005) Without nerves, immunology remains incomplete -in vivo veritas. Immunology 116:2, 145-163
CrossRef119
D.R. Ellard, J.H. Barlow, R. Mian. (2005) Perceived stress, health status, and the activity of neutrophils in undergraduates over one academic year. Stress and Health 21:4, 245-253
CrossRef120
Ruud Albers, Jean-Michel Antoine, Raphaëlle Bourdet-Sicard, Philip C. Calder, Michael Gleeson, Bruno Lesourd, Sonia Samartín, Ian R. Sanderson, Jan Van Loo, F. Willem Vas Dias, Bernhard Watzl. (2005) Markers to measure immunomodulation in human nutrition intervention studies. British Journal of Nutrition 94:03, 452
CrossRef121
Yori. Gidron, Avishag. Hassid, Hemda. Yisrael, Aya. Biderman. (2005) Do psychological factors predict occurrence of influenza-like symptoms in vaccinated elderly residents of a sheltered home?. British Journal of Health Psychology 10:3, 411-420
CrossRef122
Gunnar Aronsson, Klas Gustafsson. (2005) Sickness Presenteeism: Prevalence, Attendance-Pressure Factors, and an Outline of a Model for Research. Journal of Occupational and Environmental Medicine 47:9, 958-966
CrossRef123
Sheldon Cohen. (2005) Keynote presentation at the eight international congress of behavioral medicine Mainz, Germany August 25–28, 2004. International Journal of Behavioral Medicine 12:3, 123-131
CrossRef124
Phillip J. Brantley, Gareth R. Dutton, Karen B. Grothe, Jamie S. Bodenlos, John Howe, Glenn N. Jones. (2005) Minor Life Events as Predictors of Medical Utilization in Low Income African American Family Practice Patients. Journal of Behavioral Medicine 28:4, 395-401
CrossRef125
Nicole Y. Weekes, Jane MacLean, Dale E. Berger. (2005) Sex, stress, and health: Does stress predict health symptoms differently for the two sexes?. Stress and Health 21:3, 147-156
CrossRef126
Eve W. Johnson, Thomas K. Hughes, Eric M. Smith. (2005) ACTH Enhancement of T-Lymphocyte Cytotoxic Responses. Cellular and Molecular Neurobiology 25:3-4, 743-757
CrossRef127
Stephanie Ann Farquhar, Edith A. Parker, Amy J. Schulz, Barbara A. Israel. (2005) In their words: How Detroit residents perceive the effects of their physical environment. Local Environment 10:3, 259-274
CrossRef128
Timothy T. Houle, Thomas A. Remble, Thomas A. Houle. (2005) The Examination of Headache Activity Using Time-Series Research Designs. Headache: The Journal of Head and Face Pain 45:5, 438-444
CrossRef129
Neil Schneiderman, Gail Ironson, Scott D. Siegel. (2005) Stress and Health: Psychological, Behavioral, and Biological Determinants. Annual Review of Clinical Psychology 1:1, 607-628
CrossRef130
Ronald Glaser, Janice K. Kiecolt-Glaser. (2005) Science and society: Stress-induced immune dysfunction: implications for health. Nature Reviews Immunology 5:3, 243-251
CrossRef131
Gordon R. Bloomberg, Edith Chen. (2005) The relationship of psychologic stress with childhood asthma. Immunology and Allergy Clinics of North America 25:1, 83-105
CrossRef132
L. Passantino, L. Amati, A. Cianciotta, G. Passantino, A. Perillo, M. R. Ribaud, P. Venezia, E. Jirillo. (2005) Modifications of Serum and Cellular Parameters in Trotters After a Race. Macrophage Migration Inhibitory Activity Reduction and Serum β-Glucan Elevation. Immunopharmacology and Immunotoxicology 27:2, 299-314
CrossRef133
Cheryl L. Giscombé, Marci Lobel. (2005) Explaining Disproportionately High Rates of Adverse Birth Outcomes Among African Americans: The Impact of Stress, Racism, and Related Factors in Pregnancy.. Psychological Bulletin 131:5, 662-683
CrossRef134
Ilia J. Elenkov, Domenic G. Iezzoni, Adrian Daly, Alan G. Harris, George P. Chrousos. (2005) Cytokine Dysregulation, Inflammation and Well-Being. Neuroimmunomodulation 12:5, 255-269
CrossRef135
OAKLEY RAY. (2004) The Revolutionary Health Science of Psychoendoneuroimmunology: A New Paradigm for Understanding Health and Treating Illness. Annals of the New York Academy of Sciences 1032:1, 35-51
CrossRef136
Ling Cao, Amy Martin, Noelle Polakos, Jan A. Moynihan. (2004) Stress causes a further decrease in immunity to herpes simplex virus-1 in immunocompromised hosts. Journal of Neuroimmunology 156:1-2, 21-30
CrossRef137
Martin H. Goldrosen, Stephen E. Straus. (2004) Science and society: Complementary and alternative medicine: assessing the evidence for immunological benefits. Nature Reviews Immunology 4:11, 912-921
CrossRef138
Robert M. Sapolsky. (2004) SOCIAL STATUS AND HEALTH IN HUMANS AND OTHER ANIMALS. Annual Review of Anthropology 33:1, 393-418
CrossRef139
Gilbert C. Gee, Devon C. Payne-Sturges. (2004) Environmental Health Disparities: A Framework Integrating Psychosocial and Environmental Concepts. Environmental Health Perspectives 112:17, 1645-1653
CrossRef140
Gailen D. Marshall. (2004) Neuroendocrine mechanisms of immune dysregulation: applications to allergy and asthma. Annals of Allergy, Asthma & Immunology 93:2, S11-S17
CrossRef141
Timothy J. Loving, Kathi L. Heffner, Janice K. Kiecolt-Glaser, Ronald Glaser, William B. Malarkey. (2004) Stress Hormone Changes and Marital Conflict: Spouses' Relative Power Makes a Difference. Journal of Marriage and Family 66:3, 595-612
CrossRef142
Stephen K. Butcher, Janet M. Lord. (2004) Stress responses and innate immunity: aging as a contributory factor. Aging Cell 3:4, 151-160
CrossRef143
Michael I. Luster, Dori R. Germolec, Christine G. Parks, Laura Blaciforti, Michael Kashon, Robert Luebke. 2004. Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment. .
CrossRef144
MARTIN MLYNARIK, BARBRO B. JOHANSSON, DANIELA JEZOVA. (2004) Enriched Environment Influences Adrenocortical Response to Immune Challenge and Glutamate Receptor Gene Expression in Rat Hippocampus. Annals of the New York Academy of Sciences 1018:1, 273-280
CrossRef145
Susan M. Tarlo, Gary M. Liss, Justina M. Greene, Jim Purdham, Lisa McCaskell, Howard Kipen, Mickey Kerr. (2004) Work-attributed symptom clusters (darkroom disease) among radiographers versus physiotherapists: Associations between self-reported exposures and psychosocial stressors. American Journal of Industrial Medicine 45:6, 513-521
CrossRef146
CARL J. CHARNETSKI, FRANCIS X. BRENNAN. (2004) SEXUAL FREQUENCY AND SALIVARY IMMUNOGLOBULIN A (I
g A) 1. Psychological Reports 94:3, 839-844
CrossRef147
Elja Arjas, Jan Parner. (2004) Causal Reasoning from Longitudinal Data*. Scandinavian Journal of Statistics 31:2, 171-187
CrossRef148
ILIA J. ELENKOV. (2004) Glucocorticoids and the Th1/Th2 Balance. Annals of the New York Academy of Sciences 1024:1, 138-146
CrossRef149
Kathy L Kopnisky, David M Stoff, Dianne M Rausch. (2004) Workshop report: the effects of psychological variables on the progression of HIV-1 disease. Brain, Behavior, and Immunity 18:3, 246-261
CrossRef150
Colin J. MacKay *, Rosanna Cousins, Peter J. Kelly, Steve Lee, Ron H. McCaig. (2004) ‘Management Standards’ and work-related stress in the UK: policy background and science. Work & Stress 18:2, 91-112
CrossRef151
R. J. Wright, H. Mitchell, C. M. Visness, S. Cohen, J. Stout, R. Evans, D. R. Gold. (2004) Community Violence and Asthma Morbidity: The Inner-City Asthma Study. American Journal of Public Health 94:4, 625-632
CrossRef152
Robert Haimovici, Sean Koh, David R Gagnon, Todd Lehrfeld, Sarah Wellik. (2004) Risk factors for central serous chorioretinopathy. Ophthalmology 111:2, 244-249
CrossRef153
Robert W. Luebke, Christine Parks, Michael I. Luster. (2004) Suppression of Immune Function and Susceptibility to Infections in Humans: Association of Immune Function with Clinical Disease. Journal of Immunotoxicology 1:1, 15-24
CrossRef154
Duck-Hee Kang. (2003) Psychoneuroimmunology in nursing research: A biobehavioral model. Research in Nursing & Health 26:6, 421-423
CrossRef155
Staci D Bilbo, Randy J Nelson. (2003) Sex differences in photoperiodic and stress-induced enhancement of immune function in Siberian hamsters. Brain, Behavior, and Immunity 17:6, 462-472
CrossRef156
F. Patrick Robinson, Herbert L. Mathews, Linda Witek-Janusek. (2003) Psycho-Endocrine-Immune Response to Mindfulness-Based Stress Reduction in Individuals Infected with the Human Immunodeficiency Virus: A Quasiexperimental Study. The Journal of Alternative and Complementary Medicine 9:5, 683-694
CrossRef157
F SIROIS, M MELIAGORDON, T PYCHYL. (2003) “I'll look after my health, later”: an investigation of procrastination and health. Personality and Individual Differences 35:5, 1167-1184
CrossRef158
Ann L Coker, Ken W Watkins, Paige H Smith, Heather M Brandt. (2003) Social support reduces the impact of partner violence on health: application of structural equation models. Preventive Medicine 37:3, 259-267
CrossRef159
A. Schattner. (2003) The emotional dimension and the biological paradigm of illness: time for a change. QJM 96:9, 617-621
CrossRef160
Mark D. Gilbert. (2003) Weaving Medicine Back Together: Mind–Body Medicine in the Twenty-First Century. The Journal of Alternative and Complementary Medicine 9:4, 563-570
CrossRef161
David A. Padgett, Ronald Glaser. (2003) How stress influences the immune response. Trends in Immunology 24:8, 444-448
CrossRef162
Staci D Bilbo, Andrew K Hotchkiss, Silvana Chiavegatto, Randy J Nelson. (2003) Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. Journal of Neuroimmunology 140:1-2, 41-48
CrossRef163
Victoria E Burns, Douglas Carroll, Christopher Ring, Mark Drayson. (2003) Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms. Vaccine 21:19-20, 2523-2534
CrossRef164
Yoshihito YAMADA, Koichiro TATSUMI, Tetsuo YAMAGUCHI, Nobuhiro TANABE, Yuichi TAKIGUCHI, Takayuki KURIYAMA, Riichiro MIKAMI. (2003) Influence of stressful life events on the onset of sarcoidosis. Respirology 8:2, 186-191
CrossRef165
Ralf Schwarzer, Ute Schulz. 2003. Stressful Life Events. .
CrossRef166
Jeffrey R. Stowell, Lynanne McGuire, Ted Robles, Ronald Glaser, Janice K. Kiecolt-Glaser. 2003. Psychoneuroimmunology. .
CrossRef167
Karen B. Schmaling, Paul M. Lehrer, Jonathan M. Feldman, Nicholas D. Giardino. 2003. Asthma. .
CrossRef168
D POLTAVSKI, F RFERRARO. (2003) Stress and illness in American and Russian college students. Personality and Individual Differences 34:6, 971-982
CrossRef169
S. Chaushu, E. Yefe Nof, A. Becker, J. Shapira, G. Chaushu. (2003) Parotid salivary immunoglobulins, recurrent respiratory tract infections and gingival health in institutionalized and non-institutionalized subjects with Down's syndrome. Journal of Intellectual Disability Research 47:2, 101-107
CrossRef170
Margaret E. Kemeny. (2003) An interdisciplinary research model to investigate psychosocial cofactors in disease: Application to HIV-1 pathogenesis. Brain, Behavior, and Immunity 17:1, 62-72
CrossRef171
Jan A. Moynihan. (2003) Mechanisms of stress-induced modulation of immunity. Brain, Behavior, and Immunity 17:1, 11-16
CrossRef172
Michael H. Antoni. (2003) Psychoneuroendocrinology and psychoneuroimmunology of cancer: Plausible mechanisms worth pursuing?. Brain, Behavior, and Immunity 17:1, 84-91
CrossRef173
Hiroyuki Nakamura, Ichiyo Matsuzaki, Shinichiro Sasahara, Kotaro Hatta, Hirofumi Nagase, Yoshiko Oshita, Yukie Ogawa, Yoshitaka Nobukuni, Yasuhiro Kambayashi, Keiki Ogino. (2003) Enhancement of a Sense of Coherence and Natural Killer Cell Activity which Occurred in Subjects who Improved their Exercise Habits through Health Education in the Workplace. Journal of Occupational Health 45:5, 278-285
CrossRef174
A.C. Brown, C.I. Waslien. 2003. STRESS AND NUTRITION. , 5628-5636.
CrossRef175
Gunnar Aronsson, Lennart Svensson, Klas Gustafsson. (2003) Unwinding, Recuperation, and Health Among Compulsory School and High School Teachers in Sweden.. International Journal of Stress Management 10:3, 217-234
CrossRef176
Frank M. Perna, Michael H. Antoni, Andrew Baum, Paul Gordon, Neil Schneiderman. (2003) Cognitive behavioral stress management effects on injury and illness among competitive athletes: A Randomized Clinical trial. Annals of Behavioral Medicine 25:1, 66-73
CrossRef177
Henning Bay Nielsen. (2003) Lymphocyte Responses to Maximal Exercise. Sports Medicine 33:11, 853-867
CrossRef178
Terho Heikkinen, Asko Järvinen. (2003) The common cold. The Lancet 361:9351, 51-59
CrossRef179
A. Hart, M. A. Kamm. (2002) Mechanisms of initiation and perpetuation of gut inflammation by stress. Alimentary Pharmacology and Therapeutics 16:12, 2017-2028
CrossRef180
Ling Cao, David A Lawrence. (2002) Suppression of host resistance to Listeria monocytogenes by acute cold/restraint stress: lack of direct IL-6 involvement. Journal of Neuroimmunology 133:1-2, 132-143
CrossRef181
Firdaus S. Dhabhar. (2002) Stress-induced augmentation of immune function—The role of stress hormones, leukocyte trafficking, and cytokines. Brain, Behavior, and Immunity 16:6, 785-798
CrossRef182
Craig J. Wilson, Caleb E. Finch, Harvey J. Cohen. (2002) Cytokines and Cognition-The Case for A Head-to-Toe Inflammatory Paradigm. Journal of the American Geriatrics Society 50:12, 2041-2056
CrossRef183
Alexander W. Kusnecov, Alba Rossi-George. (2002) Stressor-induced modulation of immune function: a review of acute, chronic effects in animals. Acta Neuropsychiatrica 14:6, 279-291
CrossRef184
Laura Cousino Klein, Elizabeth J. Corwin. (2002) Seeing the unexpected: How sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders. Current Psychiatry Reports 4:6, 441-448
CrossRef185
Elizabeth Sibolboro Mezzacappa, William Guethlein, Edward S. Katkin. (2002) Breast-feeding and maternal health in online mothers. Annals of Behavioral Medicine 24:4, 299-309
CrossRef186
Errol Hamarat, Dennis Thompson, Don Steele, Ken Matheny, Carol Simons. (2002) Age Differences in Coping Resources and Satisfaction With Life Among Middle-Aged, Young-Old, and Oldest-Old Adults. The Journal of Genetic Psychology 163:3, 360-367
CrossRef187
Daniel König, Hinnak Northoff, Aloys Berg. (2002) Factors triggering upper airway infections in athletes. European Journal of Sport Science 2:4, 1-11
CrossRef188
Ann L. Coker, Paige H. Smith, Martie P. Thompson, Robert E. McKeown, Lesa Bethea, Keith E. Davis. (2002) Social Support Protects against the Negative Effects of Partner Violence on Mental Health. Journal of Women's Health & Gender-Based Medicine 11:5, 465-476
CrossRef189
Keith M Wonnacott, Robert H Bonneau. (2002) The Effects of Stress on Memory Cytotoxic T Lymphocyte-Mediated Protection against Herpes Simplex Virus Infection at Mucosal Sites. Brain, Behavior, and Immunity 16:2, 104-117
CrossRef190
Christopher F. Sharpley. (2002) Heart Rate Reactivity and Variability as Psychophysiological Links Between Stress, Anxiety, Depression, and Cardiovascular Disease: Implications for Health Psychology Interventions. Australian Psychologist 37:1, 56-62
CrossRef191
Eric V Yang, Ronald Glaser. (2002) Stress-induced immunomodulation and the implications for health. International Immunopharmacology 2:2-3, 315-324
CrossRef192
Michael Irwin. (2002) Psychoneuroimmunology of Depression: Clinical Implications. Brain, Behavior, and Immunity 16:1, 1-16
CrossRef193
M. Kilpelainen, M. Koskenvuo, H. Helenius, E. O. Terho. (2002) Stressful life events promote the manifestation of asthma and atopic diseases. Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy 32:2, 256-263
CrossRef194
R PICARD, J KLEIN. (2002) Computers that recognise and respond to user emotion: theoretical and practical implications. Interacting with Computers 14:2, 141-169
CrossRef195
Natalie Hamrick, Sheldon Cohen, Mario S. Rodriguez. (2002) Being popular can be healthy or unhealthy: Stress, social network diversity, and incidence of upper respiratory infection.. Health Psychology 21:3, 294-298
CrossRef196
Paul Lehrer, Jonathan Feldman, Nicholas Giardino, Hye-Sue Song, Karen Schmaling. (2002) Psychological aspects of asthma.. Journal of Consulting and Clinical Psychology 70:3, 691-711
CrossRef197
Susan Levenstein. (2002) Psychosocial factors in peptic ulcer and inflammatory bowel disease.. Journal of Consulting and Clinical Psychology 70:3, 739-750
CrossRef198
Kimberley M. Zittel, Shawn Lawrence, John S. Wodarski. (2002) Biopsychosocial Model of Health and Healing. Journal of Human Behavior in the Social Environment 5:1, 19-33
CrossRef199
Edith Chen, Karen A. Matthews, W. Thomas Boyce. (2002) Socioeconomic differences in children's health: How and why do these relationships change with age?. Psychological Bulletin 128:2, 295-329
CrossRef200
Gregory E. Miller, Sheldon Cohen, A. Kim Ritchey. (2002) Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model.. Health Psychology 21:6, 531-541
CrossRef201
Gregg D. Jacobs. (2001) The Physiology of Mind–Body Interactions: The Stress Response and the Relaxation Response. The Journal of Alternative and Complementary Medicine 7:supplement 1, 83-92
CrossRef202
Rosalind J. Wright, Suzanne F. Steinbach. (2001) Violence: An Unrecognized Environmental Exposure that May Contribute to Greater Asthma Morbidity in High Risk Inner-City Populations. Environmental Health Perspectives 109:10, 1085-1089
CrossRef203
Peter N. Uchakin, Brian Tobin, Michael Cubbage, Gailen Marshall, Clarence Sams. (2001) Immune Responsiveness Following Academic Stress in First-Year Medical Students. Journal of Interferon & Cytokine Research 21:9, 687-694
CrossRef204
Eric P. Zorrilla, Lester Luborsky, James R. McKay, Robert Rosenthal, Arlene Houldin, Anne Tax, Ruth McCorkle, David A. Seligman, Kelly Schmidt. (2001) The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review. Brain, Behavior, and Immunity 15:3, 199-226
CrossRef205
Susan K. Lutgendorf, Toni Tripp Reimer, Janet Schlechte, Linda M. Rubenstein. (2001) Illness episodes and cortisol in healthy older adults during a life transition. Annals of Behavioral Medicine 23:3, 166-176
CrossRef206
C Reynaert, Y Libert, P Janne. (2001) « Psychogenèse » du cancer : vers une piste psycho-neuro-endocrino-immunologique ?. Annales Médico-psychologiques, revue psychiatrique 159:4, 273-284
CrossRef207
Bahi Takkouche, Carlos Regueira, Juan Jesús Gestal-Otero. (2001) A Cohort Study of Stress and the Common Cold. Epidemiology 12:3, 345-349
CrossRef208
Shauna L. Shapiro, Ana Maria Lopez, Gary E. Schwartz, Richard Bootzin, Aurelio J. Figueredo, Carrie Jo Braden, Sarah F. Kurker. (2001) Quality of life and breast cancer: Relationship to psychosocial variables. Journal of Clinical Psychology 57:4, 501-519
CrossRef209
W. Caumo, A. P. Schmidt, C. N. Schneider, J. Bergmann, C. W. Iwamoto, D. Bandeira, M. B. C. Ferreira. (2001) Risk factors for preoperative anxiety in adults. Acta Anaesthesiologica Scandinavica 45:3, 298-307
CrossRef210
Nan E Rothrock, Susan K Lutgendorf, Karl J Kreder, Timothy Ratliff, Bridget Zimmerman. (2001) Stress and symptoms in patients with interstitial cystitis: a life stress model. Urology 57:3, 422-427
CrossRef211
Neil Schneiderman, Michael H. Antoni, Patrice G. Saab, Gail Ironson. (2001) H
EALTH PSYCHOLOGY : Psychosocial and Biobehavioral Aspects of Chronic Disease Management. Annual Review of Psychology 52:1, 555-580
CrossRef212
B.N. Henderson, A. Baum. 2001. Behavioral Medicine. , 1111-1118.
CrossRef213
B.M. Kudielka, C. Kirschbaum. 2001. Stress and Health Research. , 15170-15175.
CrossRef214
A. Steptoe. 2001. Infectious Diseases: Psychosocial Aspects. , 7422-7427.
CrossRef215
S.K. Agarwal, G.D. Marshall. (2001) Stress effects on immunity and its application to clinical immunology. Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy 31:1, 25-31
CrossRef216
Anna L. Marsland, Sheldon Cohen, Bruce S. Rabin, Stephen B. Manuck. (2001) Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults.. Health Psychology 20:1, 4-11
CrossRef217
ROY J SHEPHARD. (2000) Overview of the epidemiology of exercise immunology. Immunology and Cell Biology 78:5, 485-495
CrossRef218
Robert Grant. 2000. Stress Inventories Used in Clinical and Non-Clinical Settings. .
CrossRef219
Seija Sandberg, James Y Paton, Sara Ahola, Donna C McCann, David McGuinness, Clive R Hillary, Hannu Oja. (2000) The role of acute and chronic stress in asthma attacks in children. The Lancet 356:9234, 982-987
CrossRef220
Marie Thomas, Helen Whitney. (2000) After-effects of the common cold on mood and performance. Ergonomics 43:9, 1342-1349
CrossRef221
Renate Deinzer, Christian Kleineidam, Renate Stiller-Winkler, Helga Idel, Doris Bachg. (2000) Prolonged reduction of salivary immunoglobulin A (sIgA) after a major academic exam. International Journal of Psychophysiology 37:3, 219-232
CrossRef222
G. C. Gray, P. R. Goswami, M. D. Malasig, A. W. Hawksworth, D. H. Trump, M. A. Ryan, D. P. Schnurr. (2000) Adult Adenovirus Infections: Loss of Orphaned Vaccines Precipitates Military Respiratory Disease Epidemics. Clinical Infectious Diseases 31:3, 663-670
CrossRef223
John Paley. (2000) Asthma and dualism. Journal of Advanced Nursing 31:6, 1293-1299
CrossRef224
E.V. Yang, R. Glaser. (2000) Stress-induced immunomodulation: impact on immune defenses against infectious disease. Biomedicine & Pharmacotherapy 54:5, 245-250
CrossRef225
Susan Levenstein, Cosimo Prantera, Vilma Varvo, Maria Lia Scribano, Arnaldo Andreoli, Carlo Luzi, Massimo Arca, Eva Berto, Giustina Milite, Adriana Marcheggiano. (2000) Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. The American Journal of Gastroenterology 95:5, 1213-1220
CrossRef226
Gary G. Berntson, John T. Cacioppo. (2000) Psychobiology and Social Psychology: Past, Present, and Future. Personality and Social Psychology Review 4:1, 3-15
CrossRef227
John T. Cacioppo, Gary G. Berntson, John F. Sheridan, Martha K. McClintock. (2000) Multilevel integrative analyses of human behavior: Social neuroscience and the complementing nature of social and biological approaches.. Psychological Bulletin 126:6, 829-843
CrossRef228
Melvyn R. Werbach. (2000) Chronic Fatigue Syndrome: How Far Have We Come?. Journal of Nutritional and Environmental Medicine 10:3, 181-188
CrossRef229
Arthur A. Stone, Joshua M. Smyth, Alan Kaell, Adam Hurewitz. (2000) Structured writing about stressful events: Exploring potential psychological mediators of positive health effects.. Health Psychology 19:6, 619-624
CrossRef230
Michael H. Antoni, Dean G. Cruess, Stacy Cruess, Susan Lutgendorf, Mahendra Kumar, Gail Ironson, Nancy Klimas, Mary Ann Fletcher, Neil Schneiderman. (2000) Cognitive-behavioral stress management intervention effects on anxiety, 24-hr urinary norepinephrine output, and T-cytotoxic/suppressor cells over time among symptomatic HIV-infected gay men.. Journal of Consulting and Clinical Psychology 68:1, 31-45
CrossRef231
Ilia J Elenkov, George P Chrousos. (1999) Stress, cytokine patterns and susceptibility to disease. Best Practice & Research Clinical Endocrinology & Metabolism 13:4, 583-595
CrossRef232
N.A. Endicott. (1999) Role of brain organization in the pathogenesis of physical disease. Medical Hypotheses 53:6, 516-523
CrossRef233
SHELDON COHEN. (1999) Social Status and Susceptibility to Respiratory Infections. Annals of the New York Academy of Sciences 896:1 SOCIOECONOMIC, 246-253
CrossRef234
BRUCE S. McEWEN, TERESA SEEMAN. (1999) Protective and Damaging Effects of Mediators of Stress: Elaborating and Testing the Concepts of Allostasis and Allostatic Load. Annals of the New York Academy of Sciences 896:1 SOCIOECONOMIC, 30-47
CrossRef235
ANDREW BAUM, J. P. GAROFALO, ANN MARIE YALI. (1999) Socioeconomic Status and Chronic Stress: Does Stress Account for SES Effects on Health?. Annals of the New York Academy of Sciences 896:1 SOCIOECONOMIC, 131-144
CrossRef236
B. Evengard, R. S. Schacterle, A. L. Komaroff. (1999) Chronic fatigue syndrome: new insights and old ignorance. Journal of Internal Medicine 246:5, 455-469
CrossRef237
Ilia J Elenkov, George P Chrousos. (1999) Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to Disease. Trends in Endocrinology & Metabolism 10:9, 359-368
CrossRef238
Andrew Smith, Rachel Clark, David Nutt, Jürg Haller, Sheila Hayward, Kate Perry. (1999) Anti-oxidant vitamins and mental performance of the elderly. Human Psychopharmacology: Clinical and Experimental 14:7, 459-471
CrossRef239
Shoji Nagata, Masahiro Irie, Norio Mishima. (1999) Stress and asthma. Allergology International 48:4, 231-238
CrossRef240
D.A. Vuitton, B. de Wazières, J.L. Dupond. (1999) Psycho-immunologie: un modèle en question. La Revue de Médecine Interne 20:10, 934-946
CrossRef241
Holly G. Prigerson, Paul K. Maciejewski, Robert A. Rosenheck. (1999) The Effects of Marital Dissolution and Marital Quality on Health and Health Service Use Among Women. Medical Care 37:9, 858-873
CrossRef242
Michal Morag, Abraham Morag, Abraham Reichenberg, Bernard Lerer, Raz Yirmiya. (1999) Psychological variables as predictors of rubella antibody titers and fatigue—a prospective, double blind study. Journal of Psychiatric Research 33:5, 389-395
CrossRef243
Edward P. Sarafino, Maureen Ewing. (1999) The Hassles Assessment Scale for Students in College: Measuring the Frequency and Unpleasantness of and Dwelling on Stressful Events. Journal of American College Health 48:2, 75-83
CrossRef244
Leigh A. Rozlog, Janice K. Kiecolt-Glaser, Phillip T. Marucha, John F. Sheridan, Ronald Glaser. (1999) Stress and Immunity: Implications for Viral Disease and Wound Healing. Journal of Periodontology 70:7, 786-792
CrossRef245
K Vedhara, J.D Fox, E.C.Y Wang. (1999) The measurement of stress-related immune dysfunction in psychoneuroimmunology. Neuroscience & Biobehavioral Reviews 23:5, 699-715
CrossRef246
G. Lauc, J. Peter-Katalinic, S. Dabelic, M. Flögel. (1999) Purification and MALDI-MS Characterization of Stressin, a Stress-Associated Glycoprotein. Biological Chemistry 380:4, 443-450
CrossRef247
Robert B. Cialdini. (1999) Of tricks and tumors: Some little-recognized costs of dishonest use of effective social influence. Psychology and Marketing 16:2, 91-98
CrossRef248
Brooks B. Gump, Karen A. Matthews. (1999) Do Background Stressors Influence Reactivity to and Recovery From Acute Stressors?1. Journal of Applied Social Psychology 29:3, 469-494
CrossRef249
Janice K. Kiecolt-Glaser. (1999) Stress, Personal Relationships, and Immune Function: Health Implications. Brain, Behavior, and Immunity 13:1, 61-72
CrossRef250
Andrew Baum, Donna M. Posluszny. (1999) HEALTH PSYCHOLOGY: Mapping Biobehavioral Contributions to Health and Illness. Annual Review of Psychology 50:1, 137-163
CrossRef251
Martin Shain. (1999) The role of the workplace in the production and containment of health costs: the case of stress-related disorders. Leadership in Health Services 12:2, 1-7
CrossRef252
Carol W. Hatler. (1998) Using guided imagery in the emergency department. Journal of Emergency Nursing 24:6, 518-522
CrossRef253
SANDEEP K. AGARWAL, GAILEN D. MARSHALL. (1998) Glucocorticoid-Induced Type 1/Type 2 Cytokine Alterations in Humans: A Model for Stress-Related Immune Dysfunction. Journal of Interferon & Cytokine Research 18:12, 1059-1068
CrossRef254
P Levine. (1998) Chronic fatigue syndrome comes of age. The American Journal of Medicine 105:1, 2S-6S
CrossRef255
ANDREW STEPTOE. (1998) Coping, Control, and Health Riska. Annals of the New York Academy of Sciences 851:1 STRESS OF LIF, 470-476
CrossRef256
GORDAN LAUC, SANJA DABELIC, JERKA DUMIC, MIRNA FLOGEL. (1998) Stressin and Natural Killer Cell Activity in Professional Soldiersa. Annals of the New York Academy of Sciences 851:1 STRESS OF LIF, 526-530
CrossRef257
GORDAN LAUC, SANJA DABELIC, SANDRA SUPRAHA, MIRNA FLOGEL. (1998) Glycobiology of Stressa. Annals of the New York Academy of Sciences 851:1 STRESS OF LIF, 397-403
CrossRef258
JOHN F. SHERIDAN, CATHLEEN DOBBS, JAEHO JUNG, XIAOHONG CHU, ALEXANDRIA KONSTANTINOS, DAVID PADGETT, RONALD GLASER. (1998) Stress-Induced Neuroendocrine Modulation of Viral Pathogenesis and Immunitya. Annals of the New York Academy of Sciences 840:1 NEUROIMMUNOMO, 803-808
CrossRef259
PETER A. ANTON, FERGUS SHANAHAN. (1998) Neuroimmunomodulation in Inflammatory Bowel Disease: How Far from "Bench" to "Bedside"?a. Annals of the New York Academy of Sciences 840:1 NEUROIMMUNOMO, 723-734
CrossRef260
RONALD GLASER, JANICE K. KIECOLT-GLASER, WILLIAM B. MALARKEY, JOHN F. SHERIDAN. (1998) The Influence of Psychological Stress on the Immune Response to Vaccinesa. Annals of the New York Academy of Sciences 840:1 NEUROIMMUNOMO, 649-655
CrossRef261
FIRDAUS S. DHABHAR. (1998) Stress-Induced Enhancement of Cell-Mediated Immunitya. Annals of the New York Academy of Sciences 840:1 NEUROIMMUNOMO, 359-372
CrossRef262
ESTHER M. STERNBERG. (1998) Introduction: Overview of the Conference and the Field. Annals of the New York Academy of Sciences 840:1 NEUROIMMUNOMO, 1-8
CrossRef263
JOHN T. CACIOPPO, GARY G. BERNTSON, WILLIAM B. MALARKEY, JANICE K. KIECOLT-GLASER, JOHN F. SHERIDAN, KIRSTEN M. POEHLMANN, MARY H. BURLESON, JOHN M. ERNST, LOUISE C. HAWKLEY, RONALD GLASER. (1998) Autonomic, Neuroendocrine, and Immune Responses to Psychological Stress: The Reactivity Hypothesisa. Annals of the New York Academy of Sciences 840:1 NEUROIMMUNOMO, 664-673
CrossRef264
Kenji Iwakabe, Masako Shimada, Akio Ohta, Takashi Yahata, Yasushi Ohmi, Sonoko Habu, Takashi Nishimura. (1998) The restraint stress drives a shift in Th1/Th2 balance toward Th2-dominant immunity in mice. Immunology Letters 62:1, 39-43
CrossRef265
CHARLES L. SHERIDAN, MOIRA MULHERN, DAWN MARTIN. (1998) VALIDATION OF A SELF-REPORT MEASURE OF SOMATIC HEALTH. Psychological Reports 82:2, 679-687
CrossRef266
G GALLILI. (1998) Newcastle disease vaccines. Biotechnology Advances 16:2, 343-366
CrossRef267
Flier, Jeffrey S., Underhill, Lisa H., McEwen, Bruce S., . (1998) Protective and Damaging Effects of Stress Mediators. New England Journal of Medicine 338:3, 171-179
Full Text268
Andrew Steptoe. 1998. Psychophysiological Bases of Disease. , 39-78.
CrossRef269
Michael H. Antoni, Neil Schneiderman. 1998. HIV and AIDS. , 237-275.
CrossRef270
Andrew P. Smith. (1998) Breakfast and mental health. International Journal of Food Sciences and Nutrition 49:5, 397-402
CrossRef271
R. J. Benschop, L. Jabaaij, F. G. Oostveen, A. J. J. M. Vingerhoets, R. E. Ballieux. (1998) The influence of psychological stress on immunoregulation of latent Epstein-Barr virus. Stress Medicine 14:1, 21-29
CrossRef272
M.L Kohut, J.M Davis, D.A Jackson, L.H Colbert, A Strasner, D.A Essig, R.R Pate, A Ghaffar, E.P Mayer. (1998) The role of stress hormones in exercise-induced suppression of alveolar macrophage antiviral function. Journal of Neuroimmunology 81:1-2, 193-200
CrossRef273
Llia J. Elenkov, Jeaan Hoffman, Ronald L. Wilder. (1997) Does differential neuroendocrine control of cytokine production govern the expression of autoimmune diseases in pregnancy and the postpartum period?. Molecular Medicine Today 3:9, 379-383
CrossRef274
V CABALLO, E CARDENA. (1997) Sex differences in the perception of stressful life events in a Spanish sample: Some implications for the Axis IV of the DSM-IV. Personality and Individual Differences 23:2, 353-359
CrossRef275
Carolyn M. Mazure, Donald M. Quinlan, Malcolm B. Bowers. (1997) Recent life stressors and biological markers in newly admitted psychotic patients. Biological Psychiatry 41:8, 865-870
CrossRef276
Bruce S McEwen, Christine A Biron, Kenneth W Brunson, Karen Bulloch, William H Chambers, Firdaus S Dhabhar, Ronald H Goldfarb, Richard P Kitson, Andrew H Miller, Robert L Spencer, Jay M Weiss. (1997) The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Research Reviews 23:1-2, 79-133
CrossRef277
Mark V. Flinn, Barry G. England. (1997) Social economics of childhood glucocorticoid stress response and health. American Journal of Physical Anthropology 102:1, 33-53
CrossRef278
Elliot M. Friedman, Michael R. Irwin. (1997) Modulation of immune cell function by the autonomic nervous system. Pharmacology & Therapeutics 74:1, 27-38
CrossRef279
Susan Levenstein. (1996) Editorial: Is There Health In Wellness?. Journal of Clinical Gastroenterology 23:2, 94-96
CrossRef280
Martin Shain. (1996) Employee Assistance and Organizational Change. Employee Assistance Quarterly 12:1, 1-13
CrossRef281
D. Ben-Nathan, S. Lustig, D. Kobiler. (1996) Cold stress-induced neuroinvasiveness of attenuated arboviruses is not solely mediated by corticosterone. Archives of Virology 141:7, 1221-1229
CrossRef282
Peter Salmon, Maria Woloshynowych, Roland Valor. (1996) The measurement of beliefs about physical symptoms in English general practice patients. Social Science & Medicine 42:11, 1561-1567
CrossRef283
Sheldon Cohen. (1996) Psychological Stress, Immunity, and Upper Respiratory Infections.. Current Directions in Psychological Science 5:3, 86-90
CrossRef284
Mark V. Flinn, Robert J. Quinlan, Seamus A. Decker, Mark T. Turner, Barry G. England. (1996) Male-female differences in effects of parental absence on glucocorticoid stress response. Human Nature 7:2, 125-162
CrossRef285
Manfred Schedlowski, Reinhold E. Schmidt. (1996) Stre
und Immunsystem. Naturwissenschaften 83:5, 214-220
CrossRef286
Janice M Zeller, Nancy L McCain, Barbara Swanson. (1996) Psychoneuroimmunology: an emerging framework for nursing research. Journal of Advanced Nursing 23:4, 657-664
CrossRef287
Bennett Lorber. (1996) The common cold. Journal of General Internal Medicine 11:4, 229-236
CrossRef288
Felicia D. Roberts, Polly A. Newcomb, Amy Trentham-Dietz, Barry E. Storer. (1996) Self-reported stress and risk of breast cancer. Cancer 77:6, 1089-1093
CrossRef289
A. Craig, K. Hancock, M. Craig. (1996) The lifestyle appraisal questionnaire: A comprehensive assessment of health and stress. Psychology & Health 11:3, 331-343
CrossRef290
M VANECK. (1996) Individual differences in cortisol responses to a laboratory speech task and their relationship to responses to stressful daily events. Biological Psychology 43:1, 69-84
CrossRef291
Rick Csiernik. (1996) Wellness, Work and Employee Assistance Programming. Employee Assistance Quarterly 11:2, 1-13
CrossRef292
Sheldon Cohen, Tracy B. Herbert. (1996) HEALTH PSYCHOLOGY: Psychological Factors and Physical Disease from the Perspective of Human Psychoneuroimmunology. Annual Review of Psychology 47:1, 113-142
CrossRef293
P.K. Coyle. (1996) The neuroimmunology of multiple sclerosis. Advances in Neuroimmunology 6:2, 143-154
CrossRef294
D. A. Gust, T. P. Gordon, M. E. Wilson, A. R. Brodie, A. Ahmed-Ansari, H. M. McClure. (1996) Group formation of female pigtail macaques (Macaca nemestrina). American Journal of Primatology 39:4, 263-273
CrossRef295
Lauren B. Krupp, Dean Pollina. (1996) Neuroimmune and neuropsychiatric aspects of chronic fatigue syndrome. Advances in Neuroimmunology 6:2, 155-167
CrossRef296
Karl Goodkin, Jack E. Burkhalter, Nancy T. Blaney, Barbara Leeds, Raymond S. Tuttle, Daniel J. Feaster. (1996) A Research Derived Bereavement Support Group Technique for the HIV-1 Infected. OMEGA--Journal of Death and Dying 34:4, 279-300
CrossRef297
M. Elena Garralda. (1996) Somatisation in Children. Journal of Child Psychology and Psychiatry 37:1, 13-33
CrossRef298
George Erich Brogmus. (1996) The rise and fall ? Of mental stress claims in the USA. Work & Stress 10:1, 24-35
CrossRef299
Andrew Baum, Holly Herberman, Lorenzo Cohen. (1995) Managing stress and managing illness: Survival and quality of life in chronic disease. Journal of Clinical Psychology in Medical Settings 2:4, 309-333
CrossRef300
Karen Orts, John F. Sheridan, Susan Robinson-Whelen, Ronald Glaser, William B. Malarkey, Janice K. Kiecolt-Glaser. (1995) The reliability and validity of a structured interview for the assessment of infectious illness symptoms. Journal of Behavioral Medicine 18:6, 517-529
CrossRef301
David Mechanic. (1995) Sociological dimensions of illness behavior. Social Science & Medicine 41:9, 1207-1216
CrossRef302
Lawrence A. Labbate, Maurizio Fava, Marvin Oleshansky, Jerrel Zoltec, Andrew Litfman, Paul Harig. (1995) Physical Fitness and Perceived Stress. Psychosomatics 36:6, 555-560
CrossRef303
Spotswood L. Spruance, Thomas G. Evans, Mark B. McKeough, Louise Thai, Barbara A. Araneo, Raymond A. Daynes, Eric M. Mishkin, Aaron S. Abramovitz. (1995) Th1Th2-like immunity and resistance to herpes simplex labialis. Antiviral Research 28:1, 39-55
CrossRef304
A.M. Monteiro Silva, H.N. Newman, D.A. Oakley. (1995) Psychosocial factors in inflammatory periodontal diseases. A review. Journal of Clinical Periodontology 22:7, 516-526
CrossRef305
Frank M. Perna, Sharon L. McDowell. (1995) Role of psychological stress in cortisol recovery from exhaustive exercise among elite athletes. International Journal of Behavioral Medicine 2:1, 13-26
CrossRef306
Andrew Fullwood, M.D, Douglas A. Drossman, M.D. (1995) THE RELATIONSHIP OF PSYCHIATRIC ILLNESS WITH GASTROINTESTINAL DISEASE. Annual Review of Medicine 46:1, 483-496
CrossRef307
David Schlager, Jack Froom, Arnold Jaffe. (1995) Winter depression and functional impairment among ambulatory primary care patients. Comprehensive Psychiatry 36:1, 18-24
CrossRef308
THOMAS R. HALES, STEVEN L. SAUTER, MARTIN R. PETERSON, LAWRENCE J. FINE, VERN PUTZ-ANDERSON, LARRY R. SCHLEIFER, TROY T. OCHS, BRUCE P. BERNARD. (1994) Musculoskeletal disorders among visual display terminal users in a telecommunications company. Ergonomics 37:10, 1603-1621
CrossRef309
Harve E. Rawson, Kimberly Bloomer, Amanda Kendall. (1994) Stress, Anxiety, Depression, and Physical Illness in College Students. The Journal of Genetic Psychology 155:3, 321-330
CrossRef310
John C. Ruckdeschel, Christina G. Blanchard, Terrance Albrecht. (1994) Psychosocial oncology research. Where we have been, where we are going, and why we will not get there. Cancer 74:S4, 1458-1463
CrossRef311
W. D. A. Bruce-Jones, P. D. White, J. M. Thomas, A. W. Clare. (1994) The effect of social adversity on the fatigue syndrome, psychiatric disorders and physical recovery, following glandular fever. Psychological Medicine 24:03, 651
CrossRef312
Lennart Hammarstrom, Ann Gardulf, Viera Hammarstrom, Anna Janson, Karin Lindberg, C. I. Edvard Smith. (1994) Systemic and Topical Immunoglobulin Treatment in Immunocompromised Patients. Immunological Reviews 139:1, 43-70
CrossRef313
BORIS BIRMAHER, BRUCE S. RABIN, MANUEL R. GARCIA, UMESH JAIN, THERESA L. WHITESIDE, DOUGLAS E. WILLIAMSON, MAYADAH AL-SHABBOUT, BEVERLY C. NELSON, RONALD E. DAHL, NEAL D. RYAN. (1994) Cellular Immunity in Depressed, Conduct Disorder, and Normal Adolescents: Role of Adverse Life Events. Journal of the American Academy of Child & Adolescent Psychiatry 33:5, 671-678
CrossRef314
P. G. BARDIN, D. J. FRAENKEL, G. SANDERSON, M. DORWARD, L. C. K. LAU, S. L. JOHNSTON, S. T. HOLGATE. (1994) Amplified rhinovirus colds in atopic subjects. Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy 24:5, 457-464
CrossRef315
R. E. Stanwell, J. M. Stuart, A. O. Hughes, P. Robinson, M. B. Griffin, K. Cartwright. (1994) Smoking, the environment and meningococcal disease: a case control study. Epidemiology and Infection 112:02, 315
CrossRef316
Deborah A Gust, Thomas P Gordon, Anne R Brodie, Harold M McClure. (1994) Effect of a preferred companion in modulating stress in adult female rhesus monkeys. Physiology & Behavior 55:4, 681-684
CrossRef317
Gail Ironson, Andrea Friedman, Nancy Klimas, Michael Antoni, Mary Ann Fletcher, Arthur LaPerriere, John Simoneau, Neil Schneiderman. (1994) Distress, denial, and low adherence to behavioral interventions predict faster disease progression in gay men infected with human immunodeficiency virus. International Journal of Behavioral Medicine 1:1, 90-105
CrossRef318
David B. Pyne. (1994) Exercise, training, and the immune system. Sports Medicine, Training and Rehabilitation 5:1, 47-64
CrossRef319
Leena Hilakivi-Clarke, Julia Rowland, Robert Clarke, Marc E. Lippman. (1994) Psychosocial factors in the development and progression of breast cancer. Breast Cancer Research and Treatment 29:2, 141-160
CrossRef320
Cathleen M. Dobbs, Marco Vasquez, Ronald Glaser, John F. Sheridan. (1993) Mechanisms of stress-induced modulation of viral pathogenesis and immunity. Journal of Neuroimmunology 48:2, 151-160
CrossRef321
MICHAEL IRWIN. (1993) Stress-Induced Immune Suppression Role of the Autonomic Nervous System. Annals of the New York Academy of Sciences 697:1 Corticotropin, 203-218
CrossRef322
S Cohen, D A Tyrrell, M A Russell, M J Jarvis, A P Smith. (1993) Smoking, alcohol consumption, and susceptibility to the common cold.. American Journal of Public Health 83:9, 1277-1283
CrossRef323
D. A. J. Tyrrell, S. Cohen, J. E. Schilarb. (1993) Signs and symptoms in common colds. Epidemiology and Infection 111:01, 143
CrossRef324
David C. Nieman. (1993) Exercise and upper respiratory tract infection. Sports Medicine, Training and Rehabilitation 4:1, 1-14
CrossRef325
Mark H. Whitnall. (1993) Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Progress in Neurobiology 40:5, 573-629
CrossRef326
Barbara L. Andersen. (1993) Predicting sexual and psychologic morbidity and improving the quality of life for women with gynecologic cancer. Cancer 71:S4, 1678-1690
CrossRef327
Peter Hemmingsson, Lennart Hammarström. (1993) Nasal Administration of Immunoglobulin as Effective Prophylaxis against Infections in Elite Cross-country Skiers. Scandinavian Journal of Infectious Diseases 25:6, 783-785
CrossRef328
MARY P. KOSS. (1993) The Impact of Crime Victimization on Women's Medical Use. Journal of Women's Health 2:1, 67-72
CrossRef329
L.L. Williams, J.K. Kiecolt-Glaser, L.A. Horrocks, J.T. Hillhouse, R. Glaser. (1992) Quantitative association between altered plasma esterified omega-6 fatty acid proportions and psychological stress. Prostaglandins, Leukotrienes and Essential Fatty Acids 47:2, 165-170
CrossRef330
Arthur A. Stone, Dana H. Bovbjerg, John M. Neale, Anthony Napoli, Heiddis Valdimarsdottir, Donald Cox, Frederick G. Hayden, Jack M. Gwaltney. (1992) Development of Common Cold Symptoms Following Experimental Rhinovirus Infection is Related to Prior Stressful Life Events. Behavioral Medicine 18:3, 115-120
CrossRef331
A. P. Smith, D. A. J. Tyrrell, G. I. Barrow, P. G. Higginsaf, J. S. Willman, S. Bull, K. B. Coyle, S. Trickett. (1992) Mood and experimentally-induced respiratory virus infections and illnesses. Psychology & Health 6:3, 205-212
CrossRef332
D.A.J. Tyrrell. (1992) A view from the common cold unit. Antiviral Research 18:2, 105-125
CrossRef333
(1992) Psychological Stress and the Common Cold. New England Journal of Medicine 326:9, 644-646
Full Text334
Swartz, Motton N., . (1991) Stress and the Common Cold. New England Journal of Medicine 325:9, 654-656
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