Original Article
Perioperative Total Parenteral Nutrition in Surgical Patients
N Engl J Med 1991; 325:525-532August 22, 1991
- Abstract
- Abstract
Background.
We undertook this study to test the hypothesis that perioperative total parenteral nutrition (TPN) decreases the incidence of serious complications after major abdominal or thoracic surgical procedures in malnourished patients.
Methods.
We studied 395 malnourished patients (99 percent of them male) who required laparotomy or noncardiac thoracotomy. They were randomly assigned to receive either TPN for 7 to 15 days before surgery and 3 days afterward (the TPN group) or no perioperative TPN (the control group). The patients were monitored for complications for 90 days after surgery.
Results.
The rates of major complications during the first 30 days after surgery in the two groups were similar (TPN group, 25.5 percent; control group, 24.6 percent), as were the overall 90-day mortality rates (13.4 percent and 10.5 percent, respectively). There were more infectious complications in the TPN group than in the controls (14.1 vs. 6.4 percent; P = 0.01; relative risk, 2.20; 95 percent confidence interval, 1.19 to 4.05), but slightly more noninfectious complications in the control group (16.7 vs. 22.2 percent; P = 0.20; relative risk, 0.75; 95 percent confidence interval, 0.50 to 1.13). The increased rate of infections was confined to patients categorized as either borderline or mildly malnourished, according to Subjective Global Assessment or an objective nutritional assessment, and these patients had no demonstrable benefit from TPN. In contrast, severely malnourished patients who received TPN had fewer noninfectious complications than controls (5 vs. 43 percent; P = 0.03; relative risk, 0.12; 95 percent confidence interval, 0.02 to 0.91), with no concomitant increase in infectious complications.
Conclusions.
The use of preoperative TPN should be limited to patients who are severely malnourished unless there are other specific indications. (N Engl J Med 1991; 325:525–32.)
Media in This Article
Table 1
Reasons for the Exclusion of Patients from the Study.Table 2
Base-Line Characteristics and Outcomes 30 Days after Surgery in the Study Group and the Nonrandomized Groups.*Article Activity
- Article
Malnourished surgical patients are at greater risk for postoperative morbidity and mortality than well-nourished patients undergoing similar operations for similar indications.1 Studies attempting to define the effect of preoperative nutritional support, usually total parenteral nutrition (TPN), on the incidence of postoperative complications have been inconclusive,2 , 3 making it uncertain whether the benefits of preoperative TPN are sufficient to justify its use in malnourished surgical patients who are otherwise candidates for elective surgery. We describe the results of a cooperative multi-institutional clinical trial conducted by the Department of Veterans Affairs (VA) and designed to assess the efficacy of perioperative TPN in malnourished patients undergoing major intrathoracic or intraperitoneal operations. Our primary study objective was to determine whether perioperative TPN reduces major operative complications, mortality, or both in such patients.
Methods
The complete protocol of the clinical trial has been published elsewhere3 , 4 but is summarized here. The study was approved by the VA Cooperative Studies Human Rights Committee and local institutional review boards at the participating centers. Informed consent was obtained from the study subjects before their entry into the study.
Selection of Patients
All patients at least 21 years old who were admitted to a participating VA Medical Center before nonemergency laparotomy or thoracotomy were potentially eligible for the study. Laparotomy was defined as any nonvascular intraperitoneal operation, excluding inguinal or ventral herniorrhaphy, and thoracotomy as any non-cardiac intrathoracic operation, excluding mediastinoscopy or mediastinotomy. Patients were excluded from the study if they were expected to die of their primary disease within 90 days, had received TPN in the preceding 15 days, or had undergone an operation in the preceding 30 days. The remaining patients were considered potentially eligible for the study and were screened for any condition or conditions that would make participation impossible or potentially dangerous or that could have a substantial effect on the operative outcome that was independent of nutritional status. These reasons for exclusion are listed in Table 1Table 1
Reasons for the Exclusion of Patients from the Study.; the criteria for their diagnosis have been described elsewhere.4 The patients not excluded for these reasons then underwent nutritional screening. They were considered malnourished if they met either or both of two criteria: (1) a score of 100 or less on the Nutrition Risk Index, calculated according to the following formula: 1.519 × the serum albumin level (in grams per liter) + 0.417 × (current weight/usual weight) × 100 or (2) any two of the following: a current weight that was 95 percent of the ideal weight or less; a serum albumin level of 39.2 g per liter or less; or a serum prealbumin level of 186 mg per liter or less.
The methods used to develop these criteria have been described elsewhere.3 Patients who were too well nourished to meet either criterion were not offered study participation but were assigned to the well-nourished nonrandomized group and followed to monitor postoperative complications. The malnourished patients were informed about the study according to the VA guidelines and asked to participate. Those who declined to do so were assigned to the malnourished nonrandomized group and followed to monitor postoperative complications.
Randomized Groups and Monitoring of Complications
The patients who entered the study were randomly assigned by computer-generated random numbers to the TPN group or the control group. Patients with cancer and those without it were randomized separately to ensure an equal distribution between groups. Patients who initially consented to participate in the study but later withdrew underwent no further protocol-driven nutritional interventions or testing but were followed to monitor postoperative complications; these patients were included in the final analyses.
The patients in the TPN group received perioperative TPN through a central venous catheter in doses increasing for 72 hours to a daily caloric goal of 1000 kcal above the resting metabolic expenditure, as defined elsewhere.4 Five hundred fifty kilocalories were provided as lipid (Intralipid, KabiVitrum Laboratories, Alameda, Calif.), and the remainder as dextrose. Crystalline amino acids (Freamine III, Kendall McGaw Laboratories, Irvine, Calif.) were provided at a calorie:nitrogen ratio of 150 kcal:1 g of nitrogen. Vitamins (MVI–12 [10 ml], Armour Pharmaceutical, West Chester, Pa.) and trace elements (trace-element mix [1.0 ml], Armour) were provided daily, and electrolytes were provided as clinically indicated.
The daily TPN intake was considered adequate if the intake of macronutrients was ≥85 percent of the calculated goal. Optimal TPN was defined as 7 to 15 days of preoperative treatment at adequate levels. Patients who did not receive optimal TPN were included in the final analyses but were identified as suboptimally treated. The patients receiving TPN were permitted to eat as clinically indicated; their oral intake was recorded but not included in the determination of the adequacy of the daily intake of macronutrients. Postoperatively, TPN was continued for 72 hours; thereafter it could be continued or terminated as clinically indicated.
The control patients received no TPN (or forced enteral feedings) before surgery or for the first 72 hours after surgery. Thereafter, TPN or tube feedings could be instituted if clinically indicated. The control patients were given an oral diet as clinically indicated. Their food intake was monitored by the study dietitian, but the calorie counts were not charted except at the request of the patient's physician.
The patients receiving TPN underwent surgery after receiving adequate TPN for at least seven days. The control patients underwent surgery after at least three days of base-line observation. Surgery was permitted earlier in either group if clinically indicated.
The patients were monitored for complications related to either the operation or TPN therapy from the day of randomization until death or postoperative day 90. Complications were classified as major or minor and also as infectious or noninfectious. Monitoring included direct observation of the patient and chart review daily, continuing after discharge with biweekly clinic visits, telephone interviews, or both. The monitoring methods, objective criteria used to diagnose complications, and protocols for the evaluation of fever and suspected bacteremia have been described elsewhere.4
Statistical Approach
The primary end point for comparison was the incidence of major operative complications. On the basis of previous studies,3 we anticipated a 20 percent rate of major complications after 30 days in the control group. A reduction of this rate by half (to 10 percent) in the TPN group would be considered clinically important. Detecting a difference of this magnitude or greater at a level of statistical significance of 0.05 and a power of 0.90, with a one-tailed test of proportions, would require that there be 255 patients in each group. Thus, the goal for the accrual of patients was 510 patients for the final outcome analysis.
Five additional subanalyses to be tested by two-tailed tests were defined a priori as secondary end points. These were the comparisons of the TPN and control groups with respect to mortality, all complications (major or minor), infectious complications, noninfectious complications, and major complications after stratification according to the severity of the patient's underlying malnutrition. nutritional status was stratified according to the Nutrition Risk Index and the Subjective Global Assessment, as described by Baker et al.5 When the Nutrition Risk Index score was used, the patients were categorized as borderline malnourished (Nutrition Risk Index score, >97.5), mildly malnourished (83.5 to 97.5), or severely malnourished (<83.5). Various combinations of weight loss and hypoalbuminemia result in Nutrition Risk Index values below 83.5. In the absence of weight loss (when the patient's current weight divided by the usual weight equaled 1.0), serum albumin levels below 27.8 g per liter were required for a patient to be considered severely malnourished. With marked weight loss (e.g., current weight/usual weight = 0.8), only mild hypoalbuminemia (<33.1 g per liter) is required for the Nutrition Risk Index values to fall below 83.5. Stratification with the Subjective Global Assessment was performed on the basis of clinical information obtained from a thorough history and physical examination without knowledge of specific laboratory or anthropometric measures. The examiner came to a global assessment of the patient's nutritional status on the basis of the presence or absence of historical features or physical stigmata associated with malnutrition, without reference to a rigid scoring system based on specific criteria. At the time of the screening to determine eligibility for the study, each patient was assigned a Subjective Global Assessment rating of borderline malnourished (no stigmata of malnutrition despite having satisfied study entry criteria; corresponds to "well-nourished" rating by Baker et al.5), mildly malnourished (few or mild stigmata), or severely malnourished (multiple or severe stigmata or both).
Data were submitted to the Perry Point VA Cooperative Studies Program (CSP) Coordinating Center within 30 days, and interim analyses of outcome measures were performed every 9 months. The interim results were not revealed to the participating investigators but were reviewed by the CSP Human Rights Committee and the Study Operations Committee to ensure the safety of patients and to determine whether the study should be terminated prematurely.
Continuous variables were compared by analysis of variance, and categorical variables by either the chi-square test or Fisher's exact test. Analyses of categorical covariates were performed by the MantelHaenszel technique. All statistical analyses were two-tailed and were based on the intention-to-treat concept.
Results
Randomized Groups and Comparisons at Base Line
During the 26 months of patient accrual, 3259 patients were identified as potentially eligible for the study. Of these, 811 patients (25 percent) were excluded for one or more of the reasons shown in Table 1. Two hundred fifty-three patients were excluded because a delay in surgery of 7 to 10 days was contraindicated, 23 because TPN could not be administered or was potentially dangerous, 488 because concurrent illnesses or a psychiatric disorder precluded informed consent, and 97 (3 percent) because TPN was considered essential. Most of these 97 patients required preoperative TPN to permit bowel rest or decompression for at least three to five days before laparotomy.
Of the remaining 2448 patients who underwent nutritional screening, 1497 (61 percent) did not meet either of the nutritional criteria and were assigned to the well-nourished nonrandomized group. Of these patients, 1220 underwent surgery, and follow-up data were available for 1218. Nine hundred fifty-one patients met one or both nutritional criteria, but additional clinical evaluation before randomization showed that surgery was not indicated in 169, and they were discharged. The remaining 782 patients were eligible for randomization and were asked to participate in the study. Of these patients, 323 (41 percent) were not randomized because of refusal by the patient's physician (56 patients) or the patient (233) or for unstated reasons (34). These 323 patients were assigned to the malnourished nonrandomized group; 305 of them underwent surgery, and follow-up data were available for all 305.
During the 26-month period initially allocated to and funded for the accrual of patients, 459 patients (455 men and 4 women) consented to participate in the study and were randomly assigned to the TPN group (231) or the control group (228). Of these, 395 (86 percent) underwent surgery. Although the size of this sample fell short of the original projections, the interim analysis indicated that extending the recruitment period would be unlikely to alter the results of the study, and therefore the enrollment of patients was terminated. The sample accrued (395 patients) was not sufficient to test the original one-tailed hypothesis (that the 30-day rate of major complications would be reduced from 20 percent to 10 percent with TPN) with a power of 0.90, but it did provide a power of 0.80. Since the actual rate of major complications in the control group was approximately 25 percent, the 395 patients studied did provide a power of 0.89 for testing a revised hypothesis involving a 25 percent rate of major complications in the control group as compared with 12.5 percent in the TPN group.
The characteristics of the study patients relative to those of the patients in the two nonrandomized groups are shown in Table 2Table 2
Base-Line Characteristics and Outcomes 30 Days after Surgery in the Study Group and the Nonrandomized Groups.*. The study group was older and more malnourished and included more patients with gastrointestinal cancer than the well-nourished nonrandomized group. In most respects, the study group was similar to the malnourished nonrandomized group, although the study group was slightly more malnourished according to some criteria and included more patients with gastrointestinal cancer. The postoperative rates of morbidity and mortality were higher after 30 days in the study group than in the well-nourished nonrandomized group but were similar to those in the malnourished nonrandomized group.The TPN group and the control group were similar (P>0.15) with respect to age, sex, race, diagnosis, and most measures of nutritional status (serum prealbumin level, weight, percentage of ideal weight, triceps skin-fold thickness, arm-muscle circumference, and grip strength). Table 3Table 3
Base-Line Characteristics of the Randomized Patients.* shows the diagnoses and nutritional measures in which the two study groups had differences approaching or reaching statistical significance. When such differences occurred, the base-line nutritional depletion was uniformly more severe in the TPN group. However, a MantelHaenszel categorical covariate analysis of outcome measures, with control for the presence or absence of cancer, Subjective Global Assessment classification, and Nutrition Risk Index, did not alter the relative risks reported here (Table 4Table 4
Complications Observed within 30 Days of Surgery.*) — indicating that these imbalances did not alter the substantial findings of the study.Four patients died before surgery (2 in each group), and 60 patients (37 in the TPN group and 23 in the control group) were discharged without an operation when additional studies revealed surgery to be inappropriate or when the patient refused the operation. Table 5Table 5
Operative Procedures Performed in the Randomized Patients. shows the operative procedures undergone by the remaining 192 patients receiving TPN and 203 control patients.Nutrient Intake and Treatment-Related Complications
Of the 192 patients receiving TPN who underwent surgery, 130 completed an optimal course of TPN, 49 received suboptimal TPN, and 13 received no TPN after an initial attempt to place a central line failed and the patient refused further attempts. The mean duration of preoperative TPN at adequate levels was 7.9 days (range, 0 to 16). The intravenous, oral, and total mean preoperative daily caloric intakes for patients receiving TPN were 2109 kcal (range, 331 to 2883), 834 kcal (range, 0 to 2110), and 2944 kcal (range, 420 to 4543), respectively. Of the 203 control patients who underwent surgery, 3 who could not eat were given preoperative TPN when clinical conditions required that surgery be delayed by five or more days. The remaining control patients received no preoperative TPN or forced enterai feedings. The mean preoperative daily intake of calories by mouth in this group was 1280 kcal (range, 0 to 3342). Postoperatively, 111 patients in the TPN group received TPN for more than the three days required by the protocol, and TPN was instituted after postoperative day 3 in 24 control patients.
One hundred seventy-nine patients in the TPN group underwent a total of 310 insertions or changes of a central venous catheter, whereas 84 control patients underwent a total of 93 catheter insertions or changes for indications other than TPN. Catheterrelated complications were uncommon (Table 4), as were major metabolic disturbances, with only hyperglycemia (serum glucose level, > 16.7 mmol per liter [300 mg per deciliter]) occurring in significantly more patients receiving TPN (38, as compared with 3 control patients). Bacteremia or fungemia occurred in seven patients receiving TPN and five control patients, with one episode attributable to a TPN catheter and the remainder to other causes.
Mortality and Complications
Thirty-one of the 231 patients initially assigned to the TPN group (13.4 percent) and 24 of the 228 patients assigned to the control group (10.5 percent) died during either the preoperative period or the 90-day postoperative period. As noted above, two patients in each group died before surgery, with one death in the TPN group possibly attributable to catheter sepsis. The 30-day postoperative mortality rates were 7.3 percent (14 of 192) and 4.9 percent (10 of 203) in the TPN and control groups, respectively. During the next 60 days, seven patients in the TPN group and nine in the control group died from complications of surgery. Thus, the 90-day rates of mortality related to complications were 10.9 percent and 9.4 percent in the TPN and control groups, respectively. An additional 11 patients (8 in the TPN group and 3 in the control group) died of disease progression or an unrelated process between postoperative days 30 and 90. None of these differences in mortality were statistically significant.
The rates of major complications during the first 30 postoperative days were similar in the two groups. Forty-nine of the 192 patients receiving TPN (25.5 percent) and 50 of the 203 control patients (24.6 percent) had such complications. The overall rates of complications (major or minor) after 30 days were 37.0 percent and 36.5 percent in the TPN and control groups, respectively. The rates of complications remained similar at 90 days, with major complications occurring in 28 percent of both groups. The patients in the TPN group who completed an optimal course of TPN had fewer major complications after 30 days than the patients with a suboptimal course (19.2 vs. 38.7 percent; P<0.05), but the rate in the patients completing an optimal course was not significantly lower than that in the control patients.
Although the overall rates of complications were similar, the types of complications in the two groups were different. The rates of individual complications and the relative risks and confidence intervals for the major categories of complications are shown in Table 4. One or more major infectious complications occurred in more patients receiving TPN than control patients during the first 30 postoperative days (14.1 vs. 6.4 percent; P = 0.01). One or more major noninfectious complications occurred slightly (but not significantly) more often in the control group than in the TPN group (22.2 vs. 16.7 percent; P = 0.20). These differences are not explained by differences in base-line nutritional status, as indicated by the similar relative-risk ratios with and without covariate analysis adjusting for base-line Subjective Global Assessment. Similarly, an analysis of rates of major complications according to medical center revealed no significant differences. This pattern persisted after 90 days, with more infectious complications in the patients receiving TPN (16.7, as compared with 9.4 percent for the controls; P = 0.04) and slightly more noninfectious complications in the controls (25.1, as compared with 19.3 percent for the patients receiving TPN; P = 0.18).
Complication rates after stratification according to base-line nutritional status are shown in Table 6Table 6
Cumulative Incidence of Complications 30 Days after nutritional Stratification.. Among the control patients, the incidence of complications generally increased with increasing severity of malnutrition. This relation was not present in the patients receiving TPN, in whom the incidence of complications was similar in the various nutritional strata. The marked increase in infectious complications in the TPN group as a whole was confined to the patients identified as borderline malnourished (124 patients) or mildly malnourished (218 patients) by the Subjective Global Assessment or by a score ≥83.5 on the Nutrition Risk Index (362 patients). This difference reached statistical significance for the patients considered to be mildly malnourished on the basis of the Nutrition Risk Index (3.7 percent in the control group vs. 13.6 percent in the TPN group; P = 0.004) (Table 6). There were fewer noninfectious complications in the borderline malnourished and the mildly malnourished patients treated with TPN. Although these differences were not significant, they largely negated the increased incidence of infections, so that the overall rate of major complications (infectious plus noninfectious) was only minimally higher for the borderline malnourished patients who received TPN than for controls (24.5 vs. 18.7 percent, P = 0.53), and it was nearly identical for the mildly malnourished patients in both groups (TPN, 25.9 percent; control, 24.5 percent).Among the severely malnourished patients (a group numbering 50 on the basis of the Subjective Global Assessment and 33 on the basis of the Nutrition Risk Index), the frequency of infectious complications was similar in both the randomized groups. Noninfectious complications were less common in the severely malnourished patients receiving TPN, and this difference achieved statistical significance for patients with Nutrition Risk Index scores below 83.5 (42.9 vs. 5.3 percent for controls; P = 0.03) (Table 6). The overall rates of major complications were lower in the patients receiving TPN who were considered severely malnourished on the basis of the Subjective Global Assessment (25.8 vs. 47.4 percent; P = 0.12) or the Nutrition Risk Index score (21.1 vs. 46.7 percent; P = 0.11). These differences are numerically large but of marginal statistical significance, presumably because of the small size of the subgroups.
Discussion
We found no significant reduction in morbidity or mortality when TPN was provided to a heterogeneous group of surgical patients. The patients had no specific indications for preoperative TPN other than malnutrition, were candidates for either prompt or delayed surgery, were not preterminal, had not undergone surgery recently, and had no concurrent diseases causing major organ dysfunction. This is not to suggest that perioperative TPN would be inappropriate in patients with these characteristics, but we believed that the exclusion of such patients would reduce the confounding factors that might obscure any beneficial effect of TPN. The results of this trial will be most applicable to patients similar to those in the two randomized groups.
We also report outcome results for two nonrandomized populations. Although not directly relevant to the central findings, these results may be useful in assessing the validity of the results and their applicability to clinical settings outside the VA system. In any clinical trial, the results may be influenced if the patients who refuse to be studied differ in their characteristics from those who consent. This did not appear to be a major concern in this study, given the similarity of the base-line characteristics and the outcomes in the malnourished nonrandomized group and the study group. The low rate of complications in the well-nourished nonrandomized group as compared with the study group indicates that the nutritional criteria for eligibility effectively identified a high-risk population and that operative results that compare favorably with national norms can be achieved in the VA system in patients without extraordinary risk factors. The lack of such documentation in previous studies in high-risk populations of veterans has led to skepticism about the extrapolation of the results to non-VA populations.
The study group in this trial was determined to be malnourished on the basis of an objective nutritional assessment. From a nutritional perspective, these patients represented the worst 39 percent of the surgical candidates, identified after the exclusion of patients with major concurrent illnesses and a small group with clear-cut indications for preoperative TPN (3 percent of the patients in this study). The degree of malnutrition ranged from borderline to severe, with some patients appearing well nourished on the basis of the Subjective Global Assessment despite biochemical and anthropometric evidence of malnutrition. The effect of TPN on the operative outcome depended on each patient's base-line nutritional status. The therapeutic effects were divergent in the patients at the extremes of the spectrum of malnutrition represented by the study population.
Stratification according to nutritional status identified the patients with the most potential for harm and the most potential for benefit from TPN. Patients with mild malnutrition did not benefit from TPN but had more infectious complications. This finding was not explained by the presence of a catheter (that is, as a result of catheter sepsis or bacteremia), but instead it reflected a higher frequency of common postoperative infections (especially pneumonia and wound infections). Nor do differences in the types of operations performed explain this observation, since procedures associated with an increased risk of infection (such as open-colon procedures) were performed more often in the control patients. It is unclear whether the use of TPN was causally related to the increased rate of infection. The TPN-treated patients were hospitalized longer (mean, five days) before surgery than the control patients, perhaps permitting colonization by resistant pathogens. Alternatively, a possible role for lipid in this process is suggested by the results of a trial by Muller et al.6 in which the mortality of patients receiving preoperative lipid-based TPN was higher than that of patients receiving lipid-free TPN.
In contrast, there was no increase in the frequency of infections in the severely malnourished TPN-treated patients, but the frequency of noninfectious complications was significantly lower. These complications were primarily those indicative of the ability to heal wounds (anastomotic leaks or bronchopleural fistulae) and maintain normal organ function. This finding is consistent with the results of another study by Muller et al.,7 which demonstrated reduced morbidity and mortality when TPN was provided before gastrointestinal surgery for cancer. The patients in that study were not selected on the basis of objective evidence of malnutrition, but they were nevertheless quite malnourished (mean serum albumin level, 35 g per liter), probably because of their underlying disease (64 percent had upper gastrointestinal cancer). Thus, they may approximate the severely malnourished group in this study.
The divergence in the findings of this trial depending on the patients' base-line nutritional status is also consistent with the results of a recent meta-analysis in which 18 studies of perioperative TPN were reviewed and the results of 11 studies that met adequate design criteria were pooled.2 This analysis suggested a possible small benefit of TPN, but the 95 percent confidence intervals for the complication rates were wide. The authors concluded that any possible benefit of preoperative TPN in well-nourished patients was small and not clinically important, whereas efficacy in mildly or severely malnourished patients might be greater but would require further confirmation.
This study confirms the lack of benefit of TPN in borderline malnourished patients, provides strong evidence against clinically important efficacy in mildly or moderately malnourished patients, and suggests but does not confirm efficacy in severely malnourished patients. The severely malnourished population was small, representing less than 5 percent of the surgical candidates. These patients may be identified with a similar degree of confidence by careful Subjective Global Assessment or reliance on objective criteria. In the absence of severe malnutrition or other specific indications for preoperative TPN, most patients are probably best served by prompt surgery.
Supported by the Department of Veterans Affairs Cooperative Studies Program, with product support from Armour Pharmaceutical, West Chester, Pa.; KabiVitrum Laboratories, Alameda, Calif.; and Kendall McGaw Laboratories, Irvine, Calif.
Source Information
* Group members and their affiliations are listed in the Appendix.
From the Department of Veterans Affairs Medical Research Service, Cooperative Studies Program Coordinating Center, DVA Medical Center, Perry Point, MD 21902, where reprint requests should be addressed to William O. Williford, Ph.D.
Appendix
The following persons participated in the VA Total Parenteral Nutrition Cooperative Study Group: Gordon P. Buzby, M.D. (study chairman), University of Pennsylvania School of Medicine; Gayle Blouin, M.D., University of South Carolina School of Medicine; Cindy L. Colling, R.Ph., M.S., VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, N.M.; Lon O. Crosby, Ph.D., Numedloc, Inc., Bryn Mawr, Pa.; Jeffrey E. Doty, M.D., Good Samaritan Hospital, Los Angeles; John M. Eisenberg, M.D., M.B.A., University of Pennsylvania School of Medicine; Gary F. Fitzpatrick, M.D., Boston University School of Medicine and Boston Veterans Affairs Medical Center (VAMC); John P. Grant, M.D., Duke University Medical Center; Linda S. Knox, R.N., M.S.N., University of Pennsylvania School of Nursing; James L. Mullen, M.D., University of Pennsylvania School of Medicine; Carey P. Page, M.D., Texas Health Science Center and Audie L. Murphy Memorial Veterans Hospital; Henry A. Pitt, M.D., Johns Hopkins Medical Institutions; Thomas Pollack, M.D. (deceased); John R. Potts, III, M.D., University of Texas Health Science Center at Houston; George F. Reinhardt, M.D., Department of Veterans Affairs (DVA) Hospital (Hines, Ill.), and Loyola University, Stritch School of Medicine; Thomas O. Rumley, M.D., University of Maryland and Johns Hopkins University; Hueldine Webb, M.D., Downstate Medical Center and Brooklyn VAMC; and William O. Williford, Ph.D., Cooperative Studies Program Coordinating Center, Perry Point, Md.
The following centers and persons participated in this study: Chairman's Office, Department of Veterans Affairs Medical Center (DVAMC), Philadelphia — study chairman, Gordon P. Buzby, M.D.; study coordinator, Linda Knox, R.N., B.S.N.; secretary, Teri Beveridge; Audie L. Murphy Memorial Veterans Hospital, San Antonio, Tex. — participating investigator, Carey Page, M.D.; research nurse, Denise Ann Nicewonger, R.N.; research dietitians, Maria Margarita Rodriquez, R.D., and Audrey Anderson, R.D.; research pharmacist, Donna Kyle, R.Ph.; DVAMC, Boston — participating investigator, Garry Fitzpatrick, M.D.; research nurse, Marsha Fellows, R.N.; research dietitian, Kathy Hennessey, R.D.; research pharmacist, Emilio Conte, R.Ph.; DVAMC, Brooklyn, N.Y. — participating investigators, Thomas Pollock, M.D., and Hueldine Webb, M.D.; research nurse, Mary Doherty, R.N.; research dietitians, Julie Bukar, R.D., and Gloria Ferri, R.D.; research pharmacist, Allen Blatt, R.Ph.; DVAMC, Durham, N.C. — participating investigator, John Grant, M.D.; research nurses, Susan Curtas, R.N., M.S.N., and Ginny Anderson Williams, R.N.; research dietitian, Lisa J. Cohen, R.D.; research pharmacist, Mike Martz, R.Ph.; DVAMC, Gainesville, Fla. — participating investigator, Thomas O. Rumley, M.D.; research nurse, Ann Andel, R.N.; research dietitians, Susan Zoll, R.D., and John Davis, R.D.; research pharmacist, Thomas Munyer, R.Ph.; DVA, Edward Hines, Jr., Hospital, Chicago —participating investigator, George Reinhardt, M.D.; research nurses, Becky Zelmer, R.N., M.S.N., and Sharon Ballweber, R.N.; research dietitians, Laurel LeBeck, R.D., M.S., and Ruth Mitrenga, R.D.; research pharmacist, Raymond Byrne, R.Ph.; DVAMC, Miami — participating investigator, Arvey Rogers, M.D.; research nurse, Jim Spall, R.N.; research dietitian, Anne Orvieto, R.D.; research pharmacist, Catherine Nunez, R.Ph.; DVAMC, Nashville —participating investigators, Gayle Blouin, M.D., and John R. Potts, III, M.D.; research nurse, Gail Mayo, R.N.; research dietitians, Martha Phillips, R.D., Tish Freeman, R.D., and Rachael Stolzenburg, R.D.; research pharmacist, Kendal Melton, D.Ph.; DVAMC, Philadelphia — participating investigator, James L. Mullen, M.D.; research nurse, June L. Oberlander, R.N.; research dietitians, Barbara Visocan-Klein, R.D., M.S., and Marijo Kitko, R.D.; research pharmacist, John Callahan, R.Ph.; economic analysis, Henry A. Glick, M.S.; DVAMC, Sepulveda, Calif. — participating investigators, Henry Pitt, M.D., and Jeffrey E. Doty, M.D.; research nurses, Linda Mann, R.N., and Wendy Davidson, R.N.; research dietitian, Johanna Omark, R.D.; research pharmacist, Jeffrey Sayers, Pharm.D.; Central Laboratory, DVAMC, Philadelphia — director, Lon O. Crosby, Ph.D.; research technicians, Rick Spencer and Beth Leonberg, R.D.
Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, DVAMC, Albuquerque, N.M. — chief, Mike R. Sather, R.Ph., M.S.; study pharmacists, Clair M. Haakenson, R.Ph., M.S., Nancy A. Morgan, R.Ph., and Cindy L. Colling, R.Ph., M.S.
Cooperative Studies Program Coordinating Center, DVAMC, Perry Point, Md. — chief, Joseph Collins, D.Sc.; study biostatistician, William O. Williford, Ph.D.; systems analyst, Roderic D. Gillis; statistical programmers, Keith Rains, M.S., and William F. Krol, Ph.D.; computer programmer, Diana Preston; statistical assistants, Christine Scheffler, Mary E. Reeves, and Matoka A. Weitzel; administrative officer, Barbara A. McMullen.
Executive Committee — Gordon P. Buzby, M.D. (chairman); Carey P. Page, M.D.; George Reinhardt, M.D.; Lon O. Crosby, Ph.D.; Nancy A. Morgan, R.Ph.; Cindy L. Colling, R.Ph., M.S.; William O. Williford, Ph.D.; John Eisenberg, M.D., M.B.A., all of the University of Pennsylvania School of Medicine, Philadelphia; and George McNeal, M.D., DVAMC, Philadelphia.
Operations Committee — George L. Blackburn, M.D., Ph.D., (chairman), New England Deaconess Hospital, Boston; Michael Caldwell, M.D., Ph.D., Rhode Island Hospital, Providence, R.I.; Kursheed Jeejeebhoy, M.B., B.S., Ph.D., University of Toronto, Toronto, Ont.; Michael H. Kutner, Ph.D., Emory University, Atlanta; Albert G. Mulley, Jr., M.D., Massachusetts General Hospital, Boston.
Human Rights Committee — Jean Burchard, R.N. (chairperson), DVAMC, Perry Point, Md.; Nancy Shuger, Baltimore; Rev. Robert Grumbine, Baltimore; Herbert Hoover, Perry Point, Md.; David Celentano, Sc.D., Baltimore; Daniel Safer, M.D., Baltimore; Edgard Perez, Silver Spring, Md.; Jerome Levine, M.D., Rockville, Md.
Department of Veterans Affairs Central Office — Daniel Deykin, M.D., chief; Janet Gold, administrative officer; Ping C. Huang, Ph.D., staff assistant.
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- Citing Articles (331)
Citing Articles
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Daniel L. Chan, Lisa M. Freeman. 2012. Parenteral Nutrition. , 605-622.
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Patricia H. Worthington, Karen A. Gilbert. (2012) Parenteral Nutrition. Journal of Infusion Nursing 35:1, 52-64
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Jeffrey I. Mechanick, Mette M. Berger. (2012) Convergent Evidence and Opinion on Intensive Metabolic Support. Current Opinion in Clinical Nutrition and Metabolic Care1
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Jan Wernerman. (2012) Combined enteral and parenteral nutrition. Current Opinion in Clinical Nutrition and Metabolic Care1
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Robert Cohendy, Philippe Cuvillon, Jacques Ripart. (2011) Comment dépister et prendre en charge la dénutrition en périopératoire ?. Le Praticien en Anesthésie Réanimation
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Rachael Barlow, Patricia Price, Thomas D. Reid, Sarah Hunt, Geoffrey W.B. Clark, Timothy J. Havard, Malcolm C.A. Puntis, Wyn G. Lewis. (2011) Prospective multicentre randomised controlled trial of early enteral nutrition for patients undergoing major upper gastrointestinal surgical resection. Clinical Nutrition 30:5, 560-566
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Mandy Corrigan, Bijo John, Ezra Steiger. 2011. Parenteral Nutrition. , 343-358.
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Jill Schuman, Kishore Iyer. 2011. Perioperative Nutrition Support. , 423-436.
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Barbara S. van der Meij, Erik C. J. Phernambucq, Geert M. Fieten, Egbert F. Smit, Marinus A. Paul, Paul A. M. van Leeuwen, J. Wolter A. Oosterhuis. (2011) Nutrition During Trimodality Treatment in Stage III Non-small Cell Lung Cancer. Journal of Thoracic Oncology 6:9, 1563-1568
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Ulf O. Gustafsson, Olle Ljungqvist. (2011) Perioperative nutritional management in digestive tract surgery. Current Opinion in Clinical Nutrition and Metabolic Care 14:5, 504-509
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Stéphane M. Schneider. (2011) Nutrition préopératoire en chirurgie digestive réglée. Nutrition Clinique et Métabolisme 25:3, 177-182
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Federico Bozzetti. (2011) Peri-operative nutritional management. Proceedings of the Nutrition Society 70:03, 305-310
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James R. Fenton, Edward J. Bergeron, Michael Coello, Robert J. Welsh, Gary W. Chmielewski. (2011) Feeding Jejunostomy Tubes Placed During Esophagectomy: Are They Necessary?. The Annals of Thoracic Surgery 92:2, 504-512
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Edward M. Copeland, Jose Mario Pimiento, Stanley J. Dudrick. (2011) Total Parenteral Nutrition and Cancer: From the Beginning. Surgical Clinics of North America 91:4, 727-736
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Stanislaw Klek, Marek Sierzega, Piotr Szybinski, Kinga Szczepanek, Lucyna Scislo, Elzbieta Walewska, Jan Kulig. (2011) Perioperative nutrition in malnourished surgical cancer patients – A prospective, randomized, controlled clinical trial. Clinical Nutrition
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Imran K Bhatti, Farhan Rashid, Oliver Peacock, Mubashir Mulla, Richard Hall, Mike Larvin, Imran K Bhatti. 2011. Perioperative nutrition in patients undergoing resection for pancreatic malignancy. .
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Harriet O. Smith, Lejla Delic. 2011. Postoperative Surveillance and Perioperative Prophylaxis. , 161-234.
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Stanislaw Klek, Marek Sierzega, Piotr Szybinski, Kinga Szczepanek, Lucyna Scislo, Elzbieta Walewska, Jan Kulig. (2011) The immunomodulating enteral nutrition in malnourished surgical patients – A prospective, randomized, double-blind clinical trial. Clinical Nutrition 30:3, 282-288
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Todd M. Morgan, Dominic Tang, Kelly L. Stratton, Daniel A. Barocas, Christopher B. Anderson, Justin R. Gregg, Sam S. Chang, Michael S. Cookson, S. Duke Herrell, Joseph A. Smith, Peter E. Clark. (2011) Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma. European Urology 59:6, 923-928
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Hua Jiang, Ming-Wei Sun, Brook Hefright, Wei Chen, Charles Damien Lu, Jun Zeng. (2011) Efficacy of hypocaloric parenteral nutrition for surgical patients: A systematic review and meta-analysis. Clinical Nutrition
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Junsheng Li, Zhenling Ji, Congwei Yuan, Yanan Zhang, Weidong Chen, Xingtang Ju, Wenhao Tang. (2011) Limited Efficacy of Early Enteral Nutrition in Patients after Total Gastrectomy. Journal of Investigative Surgery 24:3, 103-108
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Kalpana Muthusamy, John M. Miles. 2011. Hyperglycemia should be Avoided in Critical Illness and the Postoperative Period. , 134-144.
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Catriona Goodlad, Edwina A. Brown. (2011) Encapsulating Peritoneal Sclerosis: What Have We Learned?. Seminars in Nephrology 31:2, 183-198
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B. Joseph, N. Kulvatunyou, A. Tang, T. O'Keeffe, J. L. Wynne, R. S. Friese, P. Rhee, R. Latifi. (2011) Total parenteral nutrition in critically ill and injured patients. European Surgery 43:1, 19-23
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Pei-Ra Ling, Charlotte Andersson, Robert Strijbosch, Sang Lee, Anthony Silvestri, Kathleen M. Gura, Mark Puder, Bruce R. Bistrian. (2011) Effects of glucose or fat calories in total parenteral nutrition on fat metabolism and systemic inflammation in rats. Metabolism 60:2, 195-205
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Stanislaw Klek. (2011) Immunonutrition in cancer patients. Nutrition 27:2, 144-145
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Sandra L. Kavalukas, Adrian Barbul. (2011) Nutrition and Wound Healing: An Update. Plastic and Reconstructive Surgery 127, 38S-43S
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Mary Theresa Lau. (2011) Parenteral Nutrition in the Malnourished. Journal of Infusion Nursing 34:5, 315-318
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Maximilien Barret, David Malka, Thomas Aparicio, Cécile Dalban, Christophe Locher, Jean-Marc Sabate, Samy Louafi, Touraj Mansourbakht, Franck Bonnetain, Alain Attar, Julien Taieb. (2011) Nutritional Status Affects Treatment Tolerability and Survival in Metastatic Colorectal Cancer Patients: Results of an AGEO Prospective Multicenter Study. Oncology 81:5-6, 395-402
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Brian Burnette, Aminah Jatoi. (2010) Parenteral nutrition in patients with cancer: recent guidelines and a need for further study. Current Opinion in Supportive and Palliative Care 4:4, 272-275
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Andrea Kopp Lugli, Thomas Schricker, Linda Wykes, Ralph Lattermann, Franco Carli. (2010) Glucose and protein kinetics in patients undergoing colorectal surgery: perioperative amino acid versus hypocaloric dextrose infusion. Metabolism 59:11, 1649-1655
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Bin Jie, Zhu-Ming Jiang, Marie T. Nolan, David T. Efron, Shai-Nan Zhu, Kang Yu, Jens Kondrup. (2010) Impact of nutritional support on clinical outcome in patients at nutritional risk: A multicenter, prospective cohort study in Baltimore and Beijing teaching hospitals. Nutrition 26:11-12, 1088-1093
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Jean-Louis Vincent, Mervyn Singer. (2010) Critical care: advances and future perspectives. The Lancet 376:9749, 1354-1361
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Jeffrey I. Mechanick, Corey Scurlock. (2010) Glycemic Control and Nutritional Strategies in the Cardiothoracic Surgical Intensive Care Unit—2010: State of the Art. Seminars in Thoracic and Cardiovascular Surgery 22:3, 230-235
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Laura Matarese. 2010. Assessment of Nutritional Status. , 17-36.
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Michelle Duggan, Brian P. Kavanagh. (2010) Perioperative modifications of respiratory function. Best Practice & Research Clinical Anaesthesiology 24:2, 145-155
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Zachariah Thomas, Farooq Bandali, Karen McCowen, Atul Malhotra. (2010) Drug-induced endocrine disorders in the intensive care unit. Critical Care Medicine 38, S219-S230
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Dominic Reeds. (2010) Near-normal glycemia for critically ill patients receiving nutrition support: fact or folly. Current Opinion in Gastroenterology 26:2, 152-155
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A. K. Annamalai, S. Mankia, N. Kandasamy, S. Donald, A. I. Adler. (2010) Continuous subcutaneous insulin usage in a patient with no gut. Diabetic Medicine 27:3, 364-366
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Mark J. Russo, Kimberly N. Hong, Ryan R. Davies, Jonathan M. Chen, Donna M. Mancini, Mehmet C. Oz, Eric A. Rose, Annetine Gelijns, Yoshifumi Naka. (2010) The Effect of Body Mass Index on Survival Following Heart Transplantation. Annals of Surgery 251:1, 144-152
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Cassius Iyad Ochoa Chaar, Tamara N. Fitzgerald, Michael Dewan, Matthew Huddle, Felix J. Schlosser, Melissa Perkal, Bart E. Muhs, Alan Dardik. (2009) Endovascular aneurysm repair is associated with less malnutrition than open abdominal aortic aneurysm repair. The American Journal of Surgery 198:5, 623-627
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Matthew Bower, Whitney Jones, Ben Vessels, Charles Scoggins, Robert Martin. (2009) Nutritional Support with Endoluminal Stenting During Neoadjuvant Therapy for Esophageal Malignancy. Annals of Surgical Oncology 16:11, 3161-3168
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Cathy Alberda, Leah Gramlich, Naomi Jones, Khursheed Jeejeebhoy, Andrew G. Day, Rupinder Dhaliwal, Daren K. Heyland. (2009) The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Medicine 35:10, 1728-1737
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M. Braga, O. Ljungqvist, P. Soeters, K. Fearon, A. Weimann, F. Bozzetti. (2009) ESPEN Guidelines on Parenteral Nutrition: Surgery. Clinical Nutrition 28:4, 378-386
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Federico Bozzetti, Alastair Forbes. (2009) The ESPEN clinical practice guidelines on Parenteral Nutrition: Present status and perspectives for future research. Clinical Nutrition 28:4, 359-364
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Sami Antoun, Annie Rey, Jacqueline Béal, Fabienne Montange, Martine Pressoir, Marie-Paule Vasson, Denis Dupoiron, Anne Gourdiat-Borye, Alain Guillaume, Brigitte Maget, Gérard Nitenberg, Bruno Raynard, Patrick Bachmann. (2009) Nutritional Risk Factors in Planned Oncologic Surgery: What Clinical and Biological Parameters Should Be Routinely Used?. World Journal of Surgery 33:8, 1633-1640
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Imran K Bhatti, Farhan Rashid, Oliver Peacock, Mubashir Mulla, Richard Hall, Mike Larvin, Imran K Bhatti. 2009. Perioperative nutrition in patients undergoing resection for pancreatic malignancy. .
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John T. Mullen, Donald W. Moorman, Daniel L. Davenport. (2009) The Obesity Paradox. Annals of Surgery 250:1, 166-172
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Matthew R. Bower, Robert C.G. Martin. (2009) Nutritional management during neoadjuvant therapy for esophageal cancer. Journal of Surgical Oncology 100:1, 82-87
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Bert Govig, Russell de Souza, Emily B. Levitan, David Crookston, Yan Kestens, Carlos O. Mendivil, Murray A. Mittleman. (2009) The Eating Assessment Table—An Evidence-Based Nutrition Tool for Clinicians. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine 8:2, 55-62
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Lauren K. Schwartz, Gilbert Cusson, Carol Semrad. (2009) Parenteral nutrition 101: a user's guide. Gastrointestinal Endoscopy 69:7, 1351-1353
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Marc Schiesser, Philipp Kirchhoff, Markus K. Müller, Markus Schäfer, Pierre-Alain Clavien. (2009) The correlation of nutrition risk index, nutrition risk score, and bioimpedance analysis with postoperative complications in patients undergoing gastrointestinal surgery. Surgery 145:5, 519-526
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Lenny M.W. van Venrooij, Paul A.M. van Leeuwen, Rien de Vos, Mieke M.M.J. Borgmeijer-Hoelen, Bas A.J.M. de Mol. (2009) Preoperative protein and energy intake and postoperative complications in well-nourished, non-hospitalized elderly cardiac surgery patients. Clinical Nutrition 28:2, 117-121
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S. Antoun, V. E. Baracos. (2009) Comment dépister la dénutrition au cours du cancer?. Oncologie 11:4, 211-217
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Ross C. Smith, James P. Ledgard, Gordon Doig, Douglas Chesher, Sarah F. Smith. (2009) An effective automated nutrition screen for hospitalized patients. Nutrition 25:3, 309-315
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Aoife M. Ryan, John V. Reynolds, Laura Healy, Miriam Byrne, Jennifer Moore, Niamh Brannelly, Aisling McHugh, Deirdre McCormack, Philomena Flood. (2009) Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) Preserves Lean Body Mass Following Esophageal Cancer Surgery: Results of a Double-Blinded Randomized Controlled Trial. Annals of Surgery 249:3, 355-363
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Katsuyoshi Kato, Shin-ichi Sugiura, Kohji Yano, Toshio Fukuoka, Akio Itoh, Masato Nagino, Toshitaka Nabeshima, Kiyofumi Yamada. (2009) The Latent Risk of Acidosis in Commercially Available Total Parenteral Nutrition (TPN) Products: a Randomized Clinical Trial in Postoperative Patients. Journal of Clinical Biochemistry and Nutrition 45:1, 68-73
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K. Lakshman. (2008) Nutritional support in gastrointestinal surgery: an overview. Indian Journal of Surgery 70:6, 265-269
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Alexander Stojadinovic, Jay W. Carlson, Gregory S. Schultz, Thomas A. Davis, Eric A. Elster. (2008) Topical advances in wound care. Gynecologic Oncology 111:2, S70-S80
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Roland N. Dickerson. (2008) Nutrition Support Pharmacist - Supporting Literature for an Evidence-Based Metabolic Support Practice. Hospital Pharmacy 43:11, 928-936
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Xiaokun Liang, Zhu-Ming Jiang, Marie T. Nolan, David T. Efron, Jens Kondrup. (2008) Comparative survey on nutritional risk and nutritional support between Beijing and Baltimore teaching hospitals. Nutrition 24:10, 969-976
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Pierre Senesse, Eric Assenat, Stéphane Schneider, Cyrus Chargari, Nicolas Magné, David Azria, Xavier Hébuterne. (2008) Nutritional support during oncologic treatment of patients with gastrointestinal cancer: Who could benefit?. Cancer Treatment Reviews 34:6, 568-575
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Matthew J. Sena, Garth H. Utter, Joseph Cuschieri, Ronald V. Maier, Ronald G. Tompkins, Brian G. Harbrecht, Ernest E. Moore, Grant E. O'Keefe. (2008) Early Supplemental Parenteral Nutrition Is Associated with Increased Infectious Complications in Critically Ill Trauma Patients. Journal of the American College of Surgeons 207:4, 459-467
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William G. Henderson, Philip W. Lavori, Peter Peduzzi, Joseph F. Collins, Mike R. Sather, John R. Feussner. 2008. Cooperative Studies Program, US Department of Veterans Affairs. .
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Marc Schiesser, Sven Müller, Philipp Kirchhoff, Stefan Breitenstein, Markus Schäfer, Pierre-Alain Clavien. (2008) Assessment of a novel screening score for nutritional risk in predicting complications in gastro-intestinal surgery. Clinical Nutrition 27:4, 565-570
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G. Y. Gandhi, M. H. Murad, D. N. Flynn, P. J. Erwin, A. B. Cavalcante, H. B. Nielsen, S. E. Capes, K. Thorlund, V. M. Montori, P. J. Devereaux. (2008) Effect of Perioperative Insulin Infusion on Surgical Morbidity and Mortality: Systematic Review and Meta-analysis of Randomized Trials. Mayo Clinic Proceedings 83:4, 418-430
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Ronald L Koretz. (2008) Parenteral nutrition and urban legends. Current Opinion in Gastroenterology 24:2, 210-214
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Ronald L. Koretz. (2008) Author’s Response. Journal of the American Dietetic Association 108:2, 223-225
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Charles W. Van Way, David A. August. (2008) Defining the Scientific Basis for Nutritional Support. Journal of the American Dietetic Association 108:2, 219-220
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Kamran Zargar-Shoshtari, Andrew G. Hill. (2008) OPTIMIZATION OF PERIOPERATIVE CARE FOR COLONIC SURGERY: A REVIEW OF THE EVIDENCE. ANZ Journal of Surgery 78:1-2, 13-23
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J.-P. Viale, S. Duperret, P. Branche, M.-O. Robert, M. Gazon. (2008) Complicanze respiratorie postoperatorie. EMC - Anestesia-Rianimazione 13:4, 1-18
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P. Senet. (2008) Fisiolog??a de la cicatrizaci??n cut??nea. EMC - Dermatolog??a 42:1, 1-10
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Aoife M. Ryan, Laura A. Healy, Derek G. Power, Suzanne P. Rowley, John V. Reynolds. (2007) Short-term nutritional implications of total gastrectomy for malignancy, and the impact of parenteral nutritional support. Clinical Nutrition 26:6, 718-727
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M. Planas, A. Peñalva, R. Burgos, C. Puiggròs, C. Pérez-Portabella, E. Espín, M. Armengol, J. Rosselló. (2007) Guidelines for colorectal cancer: Effects on nutritional intervention. Clinical Nutrition 26:6, 691-697
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Larry H. Bernstein. (2007) The systemic inflammatory response syndrome C-reactive protein and transthyretin conundrum. Clinical Chemistry and Laboratory Medicine 45:11, 1566-1567
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Kenneth A. Kudsk. (2007) Beneficial Effect of Enteral Feeding. Gastrointestinal Endoscopy Clinics of North America 17:4, 647-662
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Deverick J. Anderson, Keith S. Kaye. (2007) Skin and Soft Tissue Infections in Older Adults. Clinics in Geriatric Medicine 23:3, 595-613
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Patricia M. Sheean, Carol A. Braunschweig. (2007) Exploring the Clinical Characteristics of Parenteral Nutrition Recipients Admitted for Initial Hematopoietic Stem Cell Transplantation. Journal of the American Dietetic Association 107:8, 1398-1403
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C KUBRAK, L JENSEN. (2007) Malnutrition in acute care patients: A narrative review
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Marek Sierzega, Bogdan Niekowal, Jan Kulig, Tadeusz Popiela. (2007) Nutritional Status Affects the Rate of Pancreatic Fistula after Distal Pancreatectomy: A Multivariate Analysis of 132 Patients. Journal of the American College of Surgeons 205:1, 52-59
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Ronald L. Koretz. (2007) Do Data Support Nutrition Support? Part I: Intravenous Nutrition. Journal of the American Dietetic Association 107:6, 988-996
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Paul F. White, Henrik Kehlet, Joseph M. Neal, Thomas Schricker, Daniel B. Carr, Franco Carli. (2007) The Role of the Anesthesiologist in Fast-Track Surgery: From Multimodal Analgesia to Perioperative Medical Care. Anesthesia & Analgesia 104:6, 1380-1396
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I. A. Scott, R. S. Lodge, D. M. Russell. (2007) Evidence-based guide to perioperative medicine. Internal Medicine Journal 37:6, 389-401
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Stephen A. McClave. (2007) Nutritional Assessment in Inflammatory Bowel Disease: Application of Nutrition Strategies to the Management of the Difficult Crohn's Patient. The American Journal of Gastroenterology 102:s1, S88-S93
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Aminah Jatoi, Heidi McKean. 2007. Nutrition and Cancer. , 421-432.
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David Thomas. 2007. Nutritional Assessment in Older Persons. , 197-216.
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Liang-Yu Lin, Han-Chieh Lin, Pui-Ching Lee, Wen-Ya Ma, Hong-Da Lin. (2007) Hyperglycemia Correlates with Outcomes in Patients Receiving Total Parenteral Nutrition. The American Journal of the Medical Sciences 333:5, 261-265
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Jordan M. Winter, John L. Cameron, Charles J. Yeo, Babatunde Alao, Keith D. Lillemoe, Kurtis A. Campbell, Richard D. Schulick. (2007) Biochemical Markers Predict Morbidity and Mortality after Pancreaticoduodenectomy. Journal of the American College of Surgeons 204:5, 1029-1036
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Rebecca J. Stratton, Marinos Elia. (2007) Who benefits from nutritional support: what is the evidence?. European Journal of Gastroenterology & Hepatology 19:5, 353-358
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Khursheed N Jeejeebhoy. (2007) Enteral nutrition versus parenteral nutrition—the risks and benefits. Nature Clinical Practice Gastroenterology & Hepatology 4:5, 260-265
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Eduardo E. Montalvo-Jave, José L. Zarraga, Michael G. Sarr. (2007) Specific topics and complications of parenteral nutrition. Langenbeck's Archives of Surgery 392:2, 119-126
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Juan B. Ochoa, David Caba. (2006) Advances in Surgical Nutrition. Surgical Clinics of North America 86:6, 1483-1493
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April Clugston, Hugh M. Paterson, Kerry Yuill, O. James Garden, Rowan W. Parks. (2006) Nutritional risk index predicts a high-risk population in patients with obstructive jaundice. Clinical Nutrition 25:6, 949-954
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Tormod S. Westvik, Lauren K. Krause, Sanjeev Pradhan, Hilde H. Westvik, Stephen P. Maloney, Reuben Rutland, Fabio A. Kudo, Akihito Muto, Jose O.M. Leite, Charles Cha, Richard J. Gusberg, Alan Dardik. (2006) Malnutrition after vascular surgery: are patients with chronic renal failure at increased risk?. The American Journal of Surgery 192:5, e22-e27
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Stephen A. McClave. (2006) Critical Care Nutrition: Getting Involved as a Gastrointestinal Endoscopist. Journal of Clinical Gastroenterology 40:10, 870-890
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Hannah Piper, Tom Jaksic, Patrick Javid. 2006. Nutrition and Wound Healing at the Age Extremes. , 301-326.
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Shayn Martin, Perry Shen. 2006. Nutrition and Wound Healing in Cancer. , 261-300.
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Henning Keinke Andersen, Stephen J Lewis, Steve Thomas, Henning Keinke Andersen. 2006. Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications. .
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Kenneth A. Kudsk. (2006) Immunonutrition in Surgery and Critical Care. Annual Review of Nutrition 26:1, 463-479
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Yves Debaveye, Greet Van den Berghe. (2006) Risks and Benefits of Nutritional Support During Critical Illness. Annual Review of Nutrition 26:1, 513-538
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Fredric M. Pieracci, Philip S. Barie, Alfons Pomp. (2006) Critical care of the bariatric patient. Critical Care Medicine 34:6, 1796-1804
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Patricia M. Sheean, Sally A. Freels, W. Scott Helton, Carol A. Braunschweig. (2006) Adverse Clinical Consequences of Hyperglycemia from Total Parenteral Nutrition Exposure during Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 12:6, 656-664
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J. M. Miles. (2006) Energy Expenditure in Hospitalized Patients: Implications for Nutritional Support. Mayo Clinic Proceedings 81:6, 809-816
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Bruce R. Bistrian, Karen C. McCowen. (2006) Nutritional and metabolic support in the adult intensive care unit: Key controversies. Critical Care Medicine 34:5, 1525-1531
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John C. Hall. (2006) Nutritional Assessment of Surgery Patients. Journal of the American College of Surgeons 202:5, 837-843
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Gary P Zaloga. (2006) Parenteral nutrition in adult inpatients with functioning gastrointestinal tracts: assessment of outcomes. The Lancet 367:9516, 1101-1111
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A. Weimann, M. Braga, L. Harsanyi, A. Laviano, O. Ljungqvist, P. Soeters, K.W. Jauch, M. Kemen, J.M. Hiesmayr, T. Horbach, E.R. Kuse, K.H. Vestweber. (2006) ESPEN Guidelines on Enteral Nutrition: Surgery including Organ Transplantation. Clinical Nutrition 25:2, 224-244
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Harminder Singh, Kym Watt, Rebecca Veitch, Michael Cantor, Donald R. Duerksen. (2006) Malnutrition is prevalent in hospitalized medical patients: Are housestaff identifying the malnourished patient?. Nutrition 22:4, 350-354
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Mehmet A. Kuzu, Helin Terzioğlu, Volkan Genç, A. Bülent Erkek, Murat Özban, Pınar Sonyürek, Atilla H. Elhan, Nusret Torun. (2006) Preoperative Nutritional Risk Assessment in Predicting Postoperative Outcome in Patients Undergoing Major Surgery. World Journal of Surgery 30:3, 378-390
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Ronenn Roubenoff. 2006. Foundations of Nutritional Medicine. , 1-14.
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B.J.R. Barrass, R. Thurairaja, J.W. Collins, D. Gillatt, R.A. Persad. (2006) Optimal Nutrition Should Improve the Outcome and Costs of Radical Cystectomy. Urologia Internationalis 77:2, 139-142
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Rémy F. Meier, Christoph Beglinger. (2006) Nutrition in pancreatic diseases. Best Practice & Research Clinical Gastroenterology 20:3, 507-529
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Lisa M. Freeman, Daniel L. Chan. 2006. Total Parenteral Nutrition. , 584-601.
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E. Tsahalina, K. Razvi, M. Alkatib, C. Shaw, L. Y. Chun, D. P.J. Barton. (2006) Early enteral feeding following major abdominal surgery for recurrent gynaecological cancer. Journal of Obstetrics & Gynaecology 26:5, 457-461
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Christoph Ebener. 2006. Infusionstherapie und Ernährung. , 83-96.
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Rebecca J. Stratton, Trevor R. Smith. (2006) Role of enteral and parenteral nutrition in the patient with gastrointestinal and liver disease. Best Practice & Research Clinical Gastroenterology 20:3, 441-466
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Chikara Ueno, Kazuhiko Fukatsu, Woodae Kang, Yoshinori Maeshima, Tomoyuki Moriya, Etsuko Hara, Hidetoshi Nagayoshi, Jiro Omata, Hideaki Saito, Hoshio Hiraide, Hidetaka Mochizuki. (2005) ROUTE AND TYPE OF NUTRITION INFLUENCE NUCLEAR FACTOR ??B ACTIVATION IN PERITONEAL RESIDENT CELLS. Shock 24:4, 382-387
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Michelle Versleijen, Hennie Roelofs, Frank Preijers, Dirk Roos, Geert Wanten. (2005) Parenteral lipids modulate leukocyte phenotypes in whole blood, depending on their fatty acid composition. Clinical Nutrition 24:5, 822-829
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S. P. Allison. (2005) Integrated nutrition. Proceedings of the Nutrition Society 64:03, 319-323
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William G. Henderson, Philip W. Lavori, Peter Peduzzi, Joseph F. Collins, Mike R. Sather, John R. Feussner. 2005. Cooperative Studies Program, US Department of Veterans Affairs. .
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