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Images in Clinical Medicine

Malaria and Sickle Cell Disease

Fouad N. Boctor, M.D., Ph.D., and Joan Uehlinger, M.D.

N Engl J Med 2002; 347:e1July 4, 2002

Article

Figure 1 A 23-year-old man with sickle cell disease was admitted after reporting fever and chills. He had emigrated from West Africa three months earlier. His temperature was 38.2°C, and his other vital signs were normal. His spleen was not palpable. The hemoglobin level was 8.7 g per deciliter. Electrophoresis showed a single band of hemoglobin S consistent with the presence of hemoglobin SS sickle cell disease. Examination of a blood smear revealed a few sickle cells (arrowhead) and rare red cells with Plasmodium falciparum (arrow); the patient had had no history of malaria. Although hemoglobin S is considered to be protective against P. falciparum, this is not always the case.

Fouad N. Boctor, M.D., Ph.D.
Joan Uehlinger, M.D.
Albert Einstein College of Medicine, Bronx, NY 10461-2373

Citing Articles (1)

Citing Articles

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    Zakari Y. Aliyu. (2003) Immigration and a sneak resurgence of tuberculosis:Déjà vu. Wiener Klinische Wochenschrift 115:17-18, 611-614
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