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Showing 1 to 20 of 92 NEJM Weekly CME Exams, Past 6 Months

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  • Review Article

    Iron-overload disorders are typically insidious, causing progressive and sometimes irreversible end-organ injury before clinical symptoms develop. With a high index of suspicion, however, the consequences of iron toxicity can be attenuated or prevented. Some iron-overload disorders are quite common…

    • January 26, 2012
    • Fleming, Robert E., Ponka, Prem,
    • N Engl J Med 2012; 366:348 - 359
  • Clinical Therapeutics

    Foreword. This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are…

    • January 26, 2012
    • Pelletier, Daniel, Hafler, David A.,
    • N Engl J Med 2012; 366:339 - 347
  • Original Article

    The efficacy of neoadjuvant chemotherapy, as measured by the rate of pathological complete response (the absence of invasive and intraductal disease in the breast and the axillary lymph nodes), varies according to breast-cancer subtype. When anthracyclines, taxanes, and agents directed against…

    • January 26, 2012
    • von Minckwitz, Gunter, Eidtmann, Holger, Rezai, Mahdi, Fasching, Peter A., Tesch, Hans, Eggemann, Holm, Schrader, Iris, Kittel, Kornelia, Hanusch, Claus, Kreienberg, Rolf, Solbach, Christine, Gerber, Bernd, Jackisch, Christian, Kunz, Georg, Blohmer, Jens-Uwe, Huober, Jens, Hauschild, Maik, Fehm, Tanja, Müller, Berit Maria, Denkert, Carsten, Loibl, Sibylle, Nekljudova, Valentina, Untch, Michael,
    • N Engl J Med 2012; 366:299 - 309
  • Original Article

    Approximately 180 million people worldwide are infected with hepatitis C virus (HCV), including 4.1 million in the United States. HCV infection is the most common cause of chronic liver disease in the United States and a leading cause of cirrhosis and hepatocellular carcinoma globally. HCV is…

    • January 19, 2012
    • Lok, Anna S., Gardiner, David F., Lawitz, Eric, Martorell, Claudia, Everson, Gregory T., Ghalib, Reem, Reindollar, Robert, Rustgi, Vinod, McPhee, Fiona, Wind-Rotolo, Megan, Persson, Anna, Zhu, Kurt, Dimitrova, Dessislava I., Eley, Timothy, Guo, Tong, Grasela, Dennis M., Pasquinelli, Claudio,
    • N Engl J Med 2012; 366:216 - 224
  • Original Article

    Current osteoporosis management guidelines– recommend routine bone mineral density (BMD) screening with the use of dual-energy x-ray absorptiometry (DXA) scans for women 65 years of age or older, but no guidelines specify an osteoporosis screening interval that is based on data from longitudinal…

    • January 19, 2012
    • Gourlay, Margaret L., Fine, Jason P., Preisser, John S., May, Ryan C., Li, Chenxi, Lui, Li-Yung, Ransohoff, David F., Cauley, Jane A., Ensrud, Kristine E.,
    • N Engl J Med 2012; 366:225 - 233
  • Review Article

    Patients referred for coronary revascularization procedures are older and are likely to have more extensive extracardiac vascular disease than those referred for such procedures in the past. Despite these trends, mortality rates for coronary-artery bypass grafting (CABG), without concurrent…

    • January 19, 2012
    • Selnes, Ola A., Gottesman, Rebecca F., Grega, Maura A., Baumgartner, William A., Zeger, Scott L., McKhann, Guy M.,
    • N Engl J Med 2012; 366:250 - 257
  • Original Article

    Atrial fibrillation may be asymptomatic and consequently subclinical. Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation. About 15% of strokes are attributable to documented atrial…

    • January 12, 2012
    • Healey, Jeff S., Connolly, Stuart J., Gold, Michael R., Israel, Carsten W., Van Gelder, Isabelle C., Capucci, Alessandro, Lau, C.P., Fain, Eric, Yang, Sean, Bailleul, Christophe, Morillo, Carlos A., Carlson, Mark, Themeles, Ellison, Kaufman, Elizabeth S., Hohnloser, Stefan H.,
    • N Engl J Med 2012; 366:120 - 129
  • Clinical Practice

    Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations. Stage. A 36-year-old…

    • January 12, 2012
    • Jemec, Gregor B.E.,
    • N Engl J Med 2012; 366:158 - 164
  • Original Article

    Participation in long-distance running races has increased annually in the United States. In 2010, there were approximately 2 million participants in marathon and half-marathon races, as compared with fewer than 1 million participants in 2000. This increase has been driven in part by heightened…

    • January 12, 2012
    • Kim, Jonathan H., Malhotra, Rajeev, Chiampas, George, d'Hemecourt, Pierre, Troyanos, Chris, Cianca, John, Smith, Rex N., Wang, Thomas J., Roberts, William O., Thompson, Paul D., Baggish, Aaron L.,
    • N Engl J Med 2012; 366:130 - 140
  • Clinical Problem-Solving

    Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 50-year-old woman was admitted…

    • January 5, 2012
    • Gavin, Michael C., Morse, Danielle, Partridge, Ann H., Levy, Bruce D., Loscalzo, Joseph,
    • N Engl J Med 2012; 366:75 - 81
  • Original Article

    After an acute coronary syndrome, patients remain at risk for recurrent cardiovascular events despite standard medical therapy, including long-term antiplatelet therapy with aspirin and an adenosine diphosphate–receptor inhibitor. This risk may be related in part to excess thrombin generation…

    • January 5, 2012
    • Mega, Jessica L., Braunwald, Eugene, Wiviott, Stephen D., Bassand, Jean-Pierre, Bhatt, Deepak L., Bode, Christoph, Burton, Paul, Cohen, Marc, Cook-Bruns, Nancy, Fox, Keith A.A., Goto, Shinya, Murphy, Sabina A., Plotnikov, Alexei N., Schneider, David, Sun, Xiang, Verheugt, Freek W.A., Gibson, C. Michael,
    • N Engl J Med 2012; 366:9 - 19
  • Original Article

    Both herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can cause primary infection of the genital tract, and HSV-1 infection has become an increasingly frequent cause of genital disease. The majority of HSV infections are asymptomatic, and only 10 to 25% of persons with HSV-2 antibodies have…

    • January 5, 2012
    • Belshe, Robert B., Leone, Peter A., Bernstein, David I., Wald, Anna, Levin, Myron J., Stapleton, Jack T., Gorfinkel, Iris, Morrow, Rhoda L. Ashley, Ewell, Marian G., Stokes-Riner, Abbie, Dubin, Gary, Heineman, Thomas C., Schulte, Joann M., Deal, Carolyn D.,
    • N Engl J Med 2012; 366:34 - 43
  • Original Article

    Venous thromboembolism is an important complication in hospitalized patients.– It is estimated that if thromboprophylaxis is not administered, objectively diagnosed deep-vein thrombosis — with the potential for fatal pulmonary embolism — will develop in 10 to 20% of medical patients and in 40…

    • December 29, 2011
    • Kakkar, Ajay K., Cimminiello, Claudio, Goldhaber, Samuel Z., Parakh, Rajiv, Wang, Chen, Bergmann, Jean-François,
    • N Engl J Med 2011; 365:2463 - 2472
  • Case Records of the Massachusetts General Hospital

    Presentation of Case. Dr. Liana K. Billings (Medicine): A 52-year-old man was admitted to this hospital because of weakness and swelling in his legs. The patient had been in his usual health until 9 months earlier, when leg edema and weakness developed, associated with weight gain. His physician…

    • December 29, 2011
    • Cabot, Richard C.Harris, Nancy Lee, Shepard, Jo-Anne O., Rosenberg, Eric S., Cort, Alice M., Ebeling, Sally H.Peters, Christine C., Tritos, Nicholas A., Schaefer, Pamela W., Stein, Thor D.,
    • N Engl J Med 2011; 365:2520 - 2530
  • Original Article

    In the United States, more than 17 million red-cell units are collected annually, and 15 million units are transfused. Blood transfusions are frequently given to surgical patients and to the elderly. Yet, the indications for postoperative transfusion have not been adequately evaluated and remain…

    • December 29, 2011
    • Carson, Jeffrey L., Terrin, Michael L., Noveck, Helaine, Sanders, David W., Chaitman, Bernard R., Rhoads, George G., Nemo, George, Dragert, Karen, Beaupre, Lauren, Hildebrand, Kevin, Macaulay, William, Lewis, Courtland, Cook, Donald Richard, Dobbin, Gwendolyn, Zakriya, Khwaja J., Apple, Fred S., Horney, Rebecca A., Magaziner, Jay,
    • N Engl J Med 2011; 365:2453 - 2462
  • Interactive Medical Case

    A 50-year-old woman presented with fatigue and shortness of breath. One week before presentation, she experienced the gradual onset of dyspnea after moderate exertion, profound malaise, and a non-productive cough. In the 48 hours before admission, her shortness of breath worsened, such that she was…

    • December 22, 2011
    • McMahon, Graham T., Katz, Joel T., Levy, Bruce D., Loscalzo, Joseph, , Ross, John J., Vaidya, Anand, Gavin, Michael C., Morse, Danielle, Partridge, Ann H.,
    • N Engl J Med 2011; 365:e47
  • Clinical Practice

    Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations. Stage. A 62-year-old…

    • December 22, 2011
    • Marcocci, Claudio, Cetani, Filomena,
    • N Engl J Med 2011; 365:2389 - 2397
  • Original Article

    An impaired glomerular filtration rate (GFR) is the final common pathway of diabetic kidney disease. Once the GFR is impaired, cardiovascular disease events and progression to end-stage renal disease occur at unacceptably high rates, even with proven medical management.– This underscores the need…

    • December 22, 2011
    • The DCCT/EDIC Research Group
    • N Engl J Med 2011; 365:2366 - 2376
  • Review Article

    Focal segmental glomerulosclerosis accounts for approximately 20% of cases of the nephrotic syndrome in children and 40% of such cases in adults, with an estimated incidence of 7 per 1 million. It is the most common primary glomerular disorder causing end-stage renal disease in the United States,…

    • December 22, 2011
    • D'Agati, Vivette D., Kaskel, Frederick J., Falk, Ronald J.,
    • N Engl J Med 2011; 365:2398 - 2411
  • Original Article

    More than 18 million North Americans have coronary heart disease, and despite profound advances in both pharmacologic and interventional management, both morbidity and mortality remain appreciable. Elevated low-density lipoprotein (LDL) cholesterol levels are an established predictor of the risk of…

    • December 15, 2011
    • The AIM-HIGH Investigators
    • N Engl J Med 2011; 365:2255 - 2267

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NEJM Review CME Program

The NEJM Review CME Program is a comprehensive home study program based on the most clinically relevant New England Journal of Medicine articles.

These 50-credit exams consist of board-style questions written to emphasize key issues from the most recent six-month volume of NEJM issues. The exams are offered in March and September. Learn more about the NEJM Review CME Program.

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