Patients treated with an induction regimen of melphalan, prednisone, and lenalidomide followed by lenalidomide maintenance therapy had longer progression-free survival than those who did not receive maintenance therapy.

A 43-year-old woman with a history of atopic dermatitis was admitted to the hospital because of fever and a generalized painful, pruritic rash involving the entire body. Examination revealed vesicles, pustules, and erosions with scalloped borders. A diagnostic test result was received.

PCIs for acute coronary disease are increasingly being performed at centers without on-site surgical backup. This review summarizes the safety and the efficacy of this practice, along with the policy implications, including those for patients undergoing elective procedures.

This trial compared two thyrotropin-stimulation methods and two 131I doses for postoperative ablation in patients with low-risk thyroid cancer. Rates of ablation were similar in all treatment groups. Doses lower than those currently recommended may be adequate for this condition.

This study provides 2-year data from the PARTNER trial, in which patients with aortic stenosis received transcatheter aortic-valve replacement (TAVR) or surgical replacement. Overall mortality was similar, but paravalvular leak increased mortality in the TAVR group.

Shortness of breath, fever, and cough productive of yellow sputum developed in a 38-year-old woman soon after the birth of her third child. Although her symptoms initially resolved with antibiotics, an intermittent nonproductive cough, wheezing, and shortness of breath soon followed.

In this randomized trial involving young adults with suspected appendicitis, low-dose abdominal computed tomography (CT) was noninferior to standard-dose abdominal CT, with similar rates of negative appendectomy and appendiceal perforation in the two study groups.

In this randomized, controlled study of obese patients with type 2 diabetes, those who received medical therapy plus bariatric surgery had significantly better glycemic control at 12 months than did those who received medical therapy alone.

A 62-year-old man was admitted to this hospital because of paresthesias, weight loss, jaundice, and anemia. Diagnostic test results were received.

This review article synthesizes relevant information about hair-follicle biology and pathobiology and summarizes the clinical presentation and management of this common condition.

A 10-month-old girl was seen in the emergency department because of vomiting and episodes of unresponsiveness, which had begun suddenly 7 hours earlier. She gradually became somnolent. Vital signs, a physical examination, and brain imaging were normal.

A large PCI registry and a large CABG registry were linked to claims records, with data adjusted for propensity score, to compare clinical outcomes. Patients selected for CABG had a long-term survival advantage over those selected for PCI.

There are an estimated 50 million infections per year with the dengue virus, which is transmitted primarily by urban-adapted Aedes aegypti mosquitoes. This review summarizes pathophysiology and treatment as well as prospects for a vaccine and for vector-control approaches.

Patients with chest pain have a high hospital admission rate, but often no cardiac cause is found. In this trial, coronary CT angiography accurately identified patients who were free from coronary disease and could be safely discharged from the emergency department.

A 60-year-old man from coastal New England was admitted to this hospital because of fever, weakness, rash, and renal failure. An initial measurement of creatine kinase was 20,437 U per liter. A diagnostic test was performed.

This article provides a framework for establishing glycemic targets for patients with type 2 diabetes, taking into account both psychosocial and clinical factors, and discusses strategies to achieve the targets. First-line treatments and additional therapies are discussed.

New therapies to treat malaria are needed. In this report, in which the authors studied 1271 patients from Asia and Africa, pyronaridine–artesunate was found to be noninferior to mefloquine plus artesunate in the treatment of uncomplicated Plasmodium falciparum malaria.

A 56-year-old woman with symptoms of carpal tunnel syndrome for 6 months presented to a referral clinic with nodular lesions on her right forearm and hand and an increase in numbness and tingling in her right hand.

A 7-year-old girl with persistent, moderately severe vesicoureteral reflux has recurrent urinary tract infections while receiving prophylactic antibiotic therapy. Endoscopic correction of vesicoureteral reflux is recommended. The technique is described.

The incidence of diabetes is increasing, but that of diabetic retinopathy is falling, probably owing to better management of glucose levels, lipid abnormalities, and hypertension. Clinical trials of VEGF and PPAR-α inhibitors are improving vision and providing insights into pathogenesis.