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Marik PE
Aspiration is defined as the inhalation of oropharyngeal or gastric contents into the larynx and lower respiratory tract. 1 2 Several pulmonary syndromes may occur after aspiration, depending on the amount and nature of the aspirated material, the frequency of aspiration, and the host's response to ...
N Engl J Med 344:665, March 1, 2001 Review Article
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Adrogue HJ, Madias NE
... systolic blood pressure by an average of 2.0 mm Hg and diastolic blood pressure by an average of 1.0 mm Hg in normotensive subjects. 14 Potassium Content of Sodium-Rich Diets As compared with diets based on natural foods, diets based on processed foods are high in sodium and low in potassium. 3 10 For ...
N Engl J Med 356:1966, May 10, 2007 Review Article
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Delves PJ, Roitt IM
... bacteriophages, each bearing a different antibody of a single specificity on its surface and containing the genes for that antibody. 115 When the contents of this library are poured onto antigen-coated plastic dishes, phages bearing the relevant antibody will bind to the antigen, and those that do not ...
N Engl J Med 343:108, July 13, 2000 Review Article
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Curfman GD, Morrissey S, Drazen JM
In the issue of April 26, 2001, we published a study by Jon Sudbø et al. 1 Figures 3B and 3C of that article, which purport to represent two different patients and stages of oral epithelial dysplasia, are in fact different magnifications of the same photomicrograph. Because the results of another ...
N Engl J Med 354:638, February 9, 2006 Editorial
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Meyer TW, Hostetter TH
... renal disease undergo hemodialysis three times per week. The dialysis prescription is adjusted to remove about two thirds of the total-body urea content during each treatment ( Figure 1). This standard was adopted after clinical trials showed that to a point, patient outcomes improve with increasing ...
N Engl J Med 357:1316, September 27, 2007 Review Article
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Camilleri M
... proximal stomach serves as the reservoir of food, and the distal stomach as the grinder. 11 The physical nature, particle size, and fat and caloric content of food determine its emptying rate ( Figure 1). Non-nutrient liquids empty rapidly; the rate is fastest when there is a large volume. If there are ...
N Engl J Med 356:820, February 22, 2007 Clinical Practice
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Mangione-Smith R, DeCristofaro AH, Setodji CM, Keesey J, Klein DJ, Adams JL, Schuster MA, McGlynn EA
... validity score of 7 or higher were included in the study. Previous work has shown this method of selecting indicators to be reliable and to have content, construct, and predictive validity in other applications. 15 16 17 The criteria for selecting the clinical areas, literature reviews, procedures followed ...
N Engl J Med 357:1515, October 11, 2007 Special Article
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Papadakis MA, Teherani A, Banach MA, Knettler TR, Rattner SL, Stern DT, Veloski JJ, Hodgson CS
... designated boxes on rating forms and narrative comments), deans' letters of recommendation to residency programs, and any documents in the students' files dated before graduation. The course-evaluation forms contained items intended to capture the entirety of professional behavior. Overall Unprofessional Rating ...
N Engl J Med 353:2673, December 22, 2005 Special Article
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Spodick DH
... The primary abnormality is rapid or slow compression of all cardiac chambers as a result of increasing intrapericardial pressure. The pericardial contents first reach the limit of the pericardial reserve volume 6 — the volume that would just distend the pericardium — and the rate of expansion then ...
N Engl J Med 349:684, August 14, 2003 Review Article
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Leonard MB, Feldman HI, Shults J, Zemel BS, Foster BJ, Stallings VA
... effects of glucocorticoids on the growing skeleton. We determined the effects of long-term therapy with high-dose glucocorticoids on the bone mineral content of the lumbar spine and whole body relative to bone size and body size in children and adolescents. Methods Study Subjects The study subjects were ...
N Engl J Med 351:868, August 26, 2004 Original Article
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Sudbo J, Kildal W, Risberg B, Koppang HS, Danielsen HE, Reith A
... aberration of DNA content (ploidy) in carcinogenesis. 25 Three previous studies of the prognostic value of DNA quantitation in premalignant oral lesions included fewer than 25 patients with at least five years of follow-up. 26 27 28 In this report we describe the prognostic value of the DNA content in dysplastic ...
N Engl J Med 344:1270, April 26, 2001 Original Article
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Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI
... risk. In this regard, studies measuring triglyceride content of muscle-biopsy specimens 6 or intramyocellular lipid content by means of proton ( 1H) magnetic resonance spectroscopy 7 8 9 indicate a strong relation between intramuscular lipid content and insulin resistance in skeletal muscle. Studies have ...
N Engl J Med 350:664, February 12, 2004 Original Article
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Kulkarni N, Pierse N, Rushton L, Grigg J
... occupational settings. 7 In this study, we sought to determine the association between the carbon content of airway macrophages and lung function in a group of healthy children and the association between carbon content and variables that may affect individual exposure — such as exercise, 8 body-mass index ...
N Engl J Med 355:21, July 6, 2006 Original Article
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Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K
... subjects were interviewed by the research dietitian at the Frederic C. Bartter General Clinical Research Center and instructed not to change the calorie content of their diet or their level of physical activity. The subjects were given placebo pills, and compliance was assessed by means of a pill count on follow ...
N Engl J Med 355:2297, November 30, 2006 Original Article
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Buffon A, Biasucci LM, Liuzzo G, D'Onofrio G, Crea F, Maseri A
... patients with unstable angina, but not in those with stable angina or in controls. Activation was detected by measuring the neutrophil myeloperoxidase content, which is an index of more advanced inflammatory activation than that identified by measuring CD11b and CD18 expression. 17 18 We ascertained whether ...
N Engl J Med 347:5, July 4, 2002 Original Article
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Gulati S, Gulati K, Sugiyama T, Tanaka H, Taguchi T, Cooper MS, Stewart PM, Leonard MB, Zemel BS, Stallings VA
... glucocorticoids does not appear to be associated with deficits in bone mineral content in children with the nephrotic syndrome — results that differ from ours. 2 An important observation was a lower bone mineral content at the spine after correction for the body-mass index. The earliest changes of ...
N Engl J Med 351:2655, December 16, 2004 Correspondence
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Gilchrest BA, Eller MS, Geller AC, Yaar M
... undergoing apoptosis, can be identified easily, 62 whereas apoptotic loss of melanocytes has never been reported. One possible explanation is the high content of antiapoptotic proteins such as Bcl-2 in melanocytes. 63 64 65 Basal keratinocytes also have relatively high levels of Bcl-2 and related proteins ...
N Engl J Med 340:1341, April 29, 1999 Review Article
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Kornfeld H, Mark EJ
... A contrast-enhanced CT scan ( Figure 2) shows a smooth, sharply demarcated, round mass in the right lower lobe with peripheral enhancement. The contents of the mass are of low attenuation, which is characteristic of fluid. The mass abuts the chest wall without invading it. A smaller, irregular mass ...
N Engl J Med 341:974, September 23, 1999 Case Records of the Massachusetts General Hospital
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Hinson JT, Fantin VR, Schonberger J, Breivik N, Siem G, McDonough B, Sharma P, Keogh I, Godinho R, Santos F, Esparza A, Nicolau Y, Selvaag E, Cohen BH, Hoppel CL, Tranebjaerg L, Eavey RD, Seidman JG, Seidman CE
... transfected with wild-type yeast Bcs1, wild-type human BCS1L, empty vector (pMGL3), or human mutant BCS1L. Mitochondrial Extraction, Analysis, and Content Actively growing transformed lymphocytes were washed, and a crude mitochondrial fraction was extracted as previously described. 17 Mitochondrial preparations ...
N Engl J Med 356:809, February 22, 2007 Original Article
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Ahlborg HG, Johnell O, Turner CH, Rannevik G, Karlsson MK
Bone strength depends on material properties, such as tissue mineral content. Certain structural characteristics of the skeleton — for example, size, shape, and the three-dimensional architecture — also affect bone strength. The observed increase in the fragility of bone with age is regarded as predominantly ...
N Engl J Med 349:327, July 24, 2003 Original Article
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