On February 25, 2009, we published an article and an accompanying editorial on a randomized trial comparing the effects of reduced-calorie diets with various compositions of fat, carbohydrates, and protein on weight loss over a two-year period. Although compliance with the diets was not high, no difference in weight loss was observed among the various diets. Reduced-calorie diets appear to have similar effects on weight loss regardless of their particular compositions. In this Clinical Directions feature, we invite you to respond to questions raised by the results of the trial, to contribute your own thoughts, and to read the comments of others.

Comments from readers were accepted through March 11, 2009.