Neuroblastoma -- Linking a Common Allele to a Rare Disease

doi:10.1056/NEJMe0802701

Volume 358:2635-2637		June 12, 2008		Number 24

Neuroblastoma — Linking a Common Allele to a Rare Disease

Brian H. Kushner, M.D., and Nai-Kong V. Cheung, M.D., Ph.D.

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PubMed Citation

Neuroblastoma has a notorious reputation among solid tumorsof childhood because of its frequently massive and widespreadtumor burden. Yet stage for stage, this embryonal neoplasm ofthe sympathetic nervous system has become the most curable ofthe common pediatric solid tumors.¹ More than 90% of patientswith localized neuroblastomas, including those with spread tothe regional lymph nodes, will survive, often with little orno cytotoxic therapy. Rates of cure of metastatic neuroblastomaexceed 90% among infants (who are usually treated with low-dosechemotherapy) and are approximately 25% among toddlers; in contrast,osteomedullary metastases associated with other pediatric solid. . . [Full Text of this Article]

Source Information

From the Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York.

This article (10.1056/NEJMe0802701) was published at www.nejm.org on May 7, 2008.

This article has been cited by other articles:

(2008). The Genetics of Neuroblastoma. JWatch Neurology 2008: 2-2 [Full Text]

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