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Published at www.nejm.org January 20, 2008 (10.1056/NEJMe0800096)

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Systemic lupus erythematosus (SLE), a disease that preferentially targets women during the reproductive years, is considered by many clinicians and investigators to be the prototypic autoimmune disease. Among clinicians, this status is based on the characteristic involvement of multiple organ systems — most notably, skin, kidneys, joints, central nervous system, and cardiovascular system — with the deposition of immune complexes and complement, inflammation, and vascular damage noted by pathologists. From the perspective of the immunologist, SLE is a model disease that has provided important insights into immune-system function. As is characteristic of most complex diseases, genetic and environmental factors determine . . . [Full Text of this Article]

Source Information

From the Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York.

This article (10.1056/NEJMe0800096) was published at www.nejm.org on January 20, 2008. It will appear in the February 28 issue of the Journal.

This article has been cited by other articles:

• (2008). Unraveling the Genetic Predisposition to Systemic Lupus Erythematosus. Journal Watch Dermatology 2008: 1-1 [Full Text]