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Previous Volume 359:938-949 August 28, 2008 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hemostasis is the process that maintains the integrity of a closed, high-pressure circulatory system after vascular damage. Vessel-wall injury and the extravasation of blood from the circulation rapidly initiate events in the vessel wall and in blood that seal the breach. Circulating platelets are recruited to the site of injury, where they become a major component of the developing thrombus; blood coagulation, initiated by tissue factor, culminates in the generation of thrombin and fibrin. These events occur concomitantly (Figure 1A; also see Video, available with the full text of this article at www.nejm.org), and under normal conditions, . . . [Full Text of this Article]

Formation of a Platelet Thrombus

Two Independent Pathways to Platelet Activation

Propagation of the Platelet Thrombus

Blood Coagulation

Tissue Factor

Thrombin and Fibrin

Tissue Factor and Microparticles in Thrombotic Disorders

Hemostatic Microparticles versus Pathologic Microparticles

Cancer-Associated Thrombosis

Paroxysmal Nocturnal Hemoglobinuria

Atherothrombosis

New Strategies for Antithrombotic Agents

Source Information

From the Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, and Harvard Medical School — both in Boston.

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