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Previous Volume 359:656-657 August 7, 2008 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Ceulen et al. (April 3 issue)¹ found intracardiac gas emboli in all patients treated with polidocanol foam (air-to-liquid ratio, 4:1), noting the potential for microembolism. We corroborate this observation in a series of 45 patients treated with proprietary very-low-nitrogen (<0.8%) polidocanol microfoam (Varisolve) generated through a sterile canister system controlling bubble size. In our unpublished series, intracardiac gas emboli were detected in all patients.

An ongoing, multicenter investigational-new-drug (IND) trial involving patients with great-saphenous-vein incompetence and right-to-left cardiac shunts is investigating the clinical significance of gas emboli with the proprietary very-low-nitrogen microfoam. On pretreatment screening, the prevalence . . . [Full Text of this Article]

Related Letters:

Microembolism during Foam Sclerotherapy of Varicose Veins
Ceulen R. P.M., Sommer A., Vernooy K.
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N Engl J Med 2008; 358:1525-1526, Apr 3, 2008. Correspondence

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