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Correspondence
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Volume 359:1731-1732 October 16, 2008 Number 16
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Desensitization during Renal Transplantation

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by Vo, A. A.
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To the Editor: In their article on desensitization during renal transplantation (July 17 issue), Vo et al.1 report very encouraging results of desensitization with a rather simple and short protocol that combines two doses of intravenous immune globulin and rituximab in highly sensitized renal-transplant candidates. Although the administration of high-dose rituximab seems to have played a major role in the favorable outcomes, the type of immune globulin used in this protocol, not described in detail, should not be discounted. The efficacy of different intravenous immune globulin preparations may vary substantially in vitro2 and probably in vivo. This might be why . . . [Full Text of this Article]



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