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Volume 359:1629-1631 October 9, 2008 Number 15
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Case 19-2008: Merkel-Cell Carcinoma

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by Busse, P. M.
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To the Editor: In the Case Record, Busse et al. (June 19 issue)1 discuss a case of Merkel-cell carcinoma in a patient with human immunodeficiency virus (HIV) infection. We disagree with the discussants about similarities between Merkel-cell carcinoma and small-cell lung cancer, particularly with respect to recommendations for adjuvant chemotherapy. Busse et al. note, "Current guidelines published by the National Comprehensive Cancer Network [NCCN] state that Merkel-cell carcinomas, regardless of stage, should be treated according to paradigms established for small-cell lung cancer." In fact, adjuvant chemotherapy is not recommended by the NCCN for Merkel-cell carcinoma, since "available retrospective studies do . . . [Full Text of this Article]



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