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Volume 359:1523-1524 October 2, 2008 Number 14
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In Utero and Early-Life Conditions and Adult Health and Disease

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by Gluckman, P. D.
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To the Editor: In their article on the developmental origin of disease, Gluckman et al. (July 3 issue)1 state that "an altered long-term risk of disease is initially induced through adaptive responses that the fetus or infant makes to cues from the mother about her health or physical state." This rather narrow definition and the overall focus of the review leave out adverse responses due to maternal exposures to environmental chemicals, occupational hazards, drugs, tobacco smoking, or infection. These factors are likely to make a very large contribution to adult diseases of developmental origin, and they have the advantage of . . . [Full Text of this Article]



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