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Volume 359:1426-1427 October 2, 2008 Number 14
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The Statins in Preventive Cardiology
Daniel Steinberg, M.D., Ph.D.

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The discovery of the statins by Akira Endo and colleagues in 1976 opened the door to a new era in preventive cardiology.1 The importance of this discovery was recently underscored by Endo's receipt of the 2008 Albert Lasker Clinical Medical Research Award. By inhibiting the biosynthesis of endogenous cholesterol, the statin drugs lower elevated blood cholesterol levels much more effectively than any of the dietary or drug regimens that were available before Endo's discovery. Moreover, they have proved to be remarkably free of serious side effects.

The hypothesis that elevated blood cholesterol levels represent an important cause of atherosclerosis and . . . [Full Text of this Article]


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Dr. Steinberg is a professor emeritus, Division of Endocrinology and Metabolism, University of California, San Diego, School of Medicine, La Jolla.



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