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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.
A 3-year-old boy with a recent history of hives and wheezing after eating chocolate mousse is evaluated. At 18 months of age, contact urticaria developed after he put his hand into a cake mix containing egg. He also has a history of chronic rhinitis, nocturnal cough, severe eczema, and a previous hospitalization for recurrent wheezing. How should this child be evaluated and
The Clinical Problem
Clinical Presentation
Coexisting Conditions
Strategies and Evidence
Management
Short-Term Management
Long-Term Management
Immunization
Areas of Uncertainty
Prevention of Food Allergies
New Treatments for Food Allergies
Guidelines from Professional Societies
Conclusions and Recommendations
Source Information
From the Department of Paediatric Allergy, King's College London, and the Children's Allergy Service, Guy's and St. Thomas' National Health Service Foundation Trust — both in London.
An audio version of this article is available at www.nejm.org.
Address reprint requests to Dr. Lack at the Children's Allergy Service, 2nd Fl., South Wing, St. Thomas' Hospital, Westminster Bridge Rd., London SE1 7EH, United Kingdom, or at gideon.lack@kcl.ac.uk.
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