FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 358:2704-2715 June 19, 2008 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text PowerPoint Slide Set Purchase this article Perspective by Weiner, L. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Major conceptual and technical advances in immunology over the past 25 years have led to a new understanding of cellular and molecular interplays between the immune system and a tumor. This review deals with important new concepts in antitumor immunity and their application to immunotherapy.

Tumor Antigens

Identification

The immune system can respond to cancer cells in two ways: by reacting against tumor-specific antigens (molecules that are unique to cancer cells) or against tumor-associated antigens (molecules that are expressed differently by cancer cells and normal cells).¹ Immunity to carcinogen-induced tumors in mice is directed against the products of unique mutations of normal cellular . . . [Full Text of this Article]

Immunogenicity

Immunosurveillance of Cancer

Immunosuppression and Tumor Progression

Immunotherapy of Cancer

Immunotherapy with Antibodies and T Cells

Therapeutic Cancer Vaccines

Therapeutic Vaccines Combined with Chemotherapy

Immunoprevention of Cancer

Summary

Source Information

From the University of Pittsburgh School of Medicine, Pittsburgh.

Address reprint requests to Dr. Finn at the Department of Immunology, University of Pittsburgh School of Medicine, E1044, Biomedical Science Tower, Pittsburgh, PA 15261, or at ojfinn@pitt.edu.

Related Letters:

Cancer Immunotherapy
Rosenberg S. A., Dudley M. E., Restifo N. P., Prestwich R., Vile R., Melcher A., Weiner L. M.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:1072-1073, Sep 4, 2008. Correspondence

This article has been cited by other articles:

• Rosenberg, S. A., Dudley, M. E., Restifo, N. P., Prestwich, R., Vile, R., Melcher, A., Weiner, L. M. (2008). Cancer immunotherapy.. NEJM 359: 1072-1072 [Full Text]