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Volume 358:2537-2539 June 12, 2008 Number 24
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Redefining Quality — Implications of Recent Clinical Trials
Harlan M. Krumholz, M.D., and Thomas H. Lee, M.D.

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Simple approaches to patient care are better — except when they are not. Recent clinical studies are leading to a reexamination of the paradigm whereby efforts to prevent vascular disease focus on the achievement of particular levels of risk factors such as low-density lipoprotein (LDL) cholesterol, systolic blood pressure, and glycated hemoglobin. Although these factors and their levels are important determinants of the development and progression of vascular disease, it is increasingly apparent that the specific strategies used to modify them make a critical difference in patient outcomes. This insight has implications for clinical practice, performance measurement, and regulatory requirements.

. . . [Full Text of this Article]


Source Information

Dr. Krumholz is a professor of medicine at Yale University School of Medicine and director of the Center for Outcomes Research and Evaluation at Yale–New Haven Hospital — both in New Haven, CT. Dr. Lee is network president of Partners HealthCare System in Boston and an associate editor of the Journal.

This article (10.1056/NEJMp0803740) was published at www.nejm.org on June 6, 2008.



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