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Previous Volume 358:2287-2289 May 22, 2008 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although in the absence of treatment, the acquired immunodeficiency syndrome (AIDS) generally develops 8 to 10 years after infection with human immunodeficiency virus (HIV) type 1 (HIV-1), the onslaught on the immune system by HIV-1 begins with the rapid depletion of memory CD4+ T cells, the majority of which reside in the gut. A recent report by Arthos et al.¹ suggests that HIV-1 is able to mediate depletion of gut CD4+ T cells in part by co-opting the molecule that helps direct T cells to the gut: the integrin ₄β₇.

Although depletion of CD4+ T cells is ultimately reflected . . . [Full Text of this Article]

Source Information

From the New England Primate Research Center, Harvard Medical School, Southborough, MA; and the Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Boston.

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