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Clinical Implications of Basic Research
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Volume 358:1860-1861 April 24, 2008 Number 17
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Mast Cells and Pancreatic Cancer
Theoharis C. Theoharides, Ph.D., M.D.

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Pancreatic ductal adenocarcinoma is probably the most lethal cancer, with a median survival of less than 6 months and a 5-year survival rate of less than 5%. The cause of pancreatic ductal adenocarcinoma is unknown, and this type of cancer resists all currently available treatments. Increasing evidence indicates that inflammation around tumors, including infiltration by mast cells, facilitates cancer growth, especially that of pancreatic ductal adenocarcinoma.1

Mast cells are derived from a unique bone marrow precursor, and they mature in the tissues. They are commonly known for their role in allergic and anaphylactic reactions, during which they secrete numerous vasoactive, . . . [Full Text of this Article]


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From the Tufts University School of Medicine and Tufts Medical Center — both in Boston.



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