Testosterone treatment for elderly men made the news again recently,when the Institute of Medicine Committee on Assessing the Needfor Clinical Trials of Testosterone Replacement Therapy issuedits long-awaited report,1 which concluded that there is insufficientevidence that testosterone treatment benefits elderly men. Whatis the background behind this report, and what are its implications?
Many studies document that serum testosterone concentrationsin men decrease as they age. In contrast to the precipitousand profound decrease in estradiol concentrations that occurwhen women enter menopause, the decrease in testosterone inmen occurs moderately and gradually over a period of . . . [Full Text of this Article]
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From the Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia.
Related Letters:
Risks of Testosterone Replacement
Shames D. A., Schaeffer E. M., Walsh P. C., Redmond G., Harris R. M., Morgentaler A., Rhoden E. L.
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N Engl J Med 2004;
350:2004-2006, May 6, 2004.
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