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Volume 323:1-6 July 5, 1990 Number 1 Next

	Full Text PDF Editorial by Vance, M. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Vance, M. L. PubMed Citation

Editor's Note, posted February 26, 2003: This article has been cited in potentially misleading e-mail advertisements. To give readers more complete information, the full text of the article, its accompanying editorial, and more recent articles about advertising dietary supplements and the question of growth hormone's role in the aging process have been made available online at no charge. The articles being made available are listed below: Effects of Human Growth Hormone in Men over 60 Years Old Growth Hormone for the Elderly? Inappropriate Advertising of Dietary Supplements Can Growth Hormone Prevent Aging?

ABSTRACT

Background The declining activity of the growth hormone–insulin-like growth factor I (IGF-I) axis with advancing age may contribute to the decrease in lean body mass and the increase in mass of adipose tissue that occur with aging.

Methods To test this hypothesis, we studied 21 healthy men from 61 to 81 years old who had plasma IGF-I concentrations of less than 350 U per liter during a six-month base-line period and a six-month treatment period that followed. During the treatment period, 12 men (group 1) received approximately 0.03 mg of biosynthetic human growth hormone per kilogram of body weight subcutaneously three times a week, and 9 men (group 2) received no treatment. Plasma IGF-I levels were measured monthly. At the end of each period we measured lean body mass, the mass of adipose tissue, skin thickness (epidermis plus dermis), and bone density at nine skeletal sites.

Results In group 1, the mean plasma IGF-I level rose into the youthful range of 500 to 1500 U per liter during treatment, whereas in group 2 it remained below 350 U per liter. The administration of human growth hormone for six months in group 1 was accompanied by an 8.8 percent increase in lean body mass, a 14.4 percent decrease in adipose-tissue mass, and a 1.6 percent increase in average lumbar vertebral bone density (P<0.05 in each instance). Skin thickness increased 7.1 percent (P=0.07). There was no significant change in the bone density of the radius or proximal femur. In group 2 there was no significant change in lean body mass, the mass of adipose tissue, skin thickness, or bone density during treatment.

Conclusions Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age. (N Engl J Med 1990; 323:1-6.)

Source Information

From the Department of Medicine, Medical College of Wisconsin, Milwaukee (D.R., I.W.R.); the Medical Service, Veterans Affairs Medical Center, Milwaukee (D.R.); the Department of Medicine, Chicago Medical School, North Chicago (A.G.F., H.S.N., G.A.G., P.Y.L., L.C.); the Medicine (A.G.F., H.S.N., P.Y.L.), Nuclear Medicine (G.A.G.), and Dental (A.F.G.) Services, Veterans Affairs Medical Center, North Chicago; the Argonne National Laboratory, Argonne, Ill. (R.A.S.); and the Epidemiology–Biometry Program, University of Illinois School of Public Health, Chicago (D.E.M.).

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