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Perspective
Assessing Competency for Concealed-Weapons Permits — The Physician's Role
Shortly after the shootings in Newtown, Connecticut, two of us received letters from our county sheriff in North Carolina asking whether one of our patients had medical or physical conditions that would preclude issuance of a permit to carry a concealed weapon. Uncomfortable with our limited…
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Perspective

Guantanamo Bay: A Medical Ethics–free Zone?
American physicians have not widely criticized medical policies at the Guantanamo Bay detainment camp that violate medical ethics. We believe they should. Actions violating medical ethics, taken on behalf of the government, devalue medical ethics for all physicians. The ongoing hunger strike at…
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Perspective

Force-Feeding, Autonomy, and the Public Interest
Hunger striking is a nonviolent act of political protest. It is not the expression of a wish to die, nor is it akin to the decision of a terminally ill patient to discontinue food and fluid intake. Rather, it is brinkmanship. Faced with hunger-striking detainees, prison authorities have three…
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Perspective

In Support of SUPPORT — A View from the NIH
Each year in the United States, nearly 500,000 infants — 1 in every 8 — are born prematurely, before 37 weeks of gestation. Despite substantial advances in their care, premature infants face a daunting array of challenges; they are at high risk for death in infancy and face severe and lifelong…
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Correspondence

The OHRP and SUPPORT
To the Editor: We are a group of scholars and leaders in bioethics and pediatrics with extensive experience in ethical and regulatory issues in pediatrics and human subjects research. We urge the Office for Human Research Protections (OHRP) to withdraw its notification to the institutions involved…
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Editorial
Informed Consent and SUPPORT
In the summer of 1963, the nation watched in sadness as Patrick Bouvier Kennedy, the youngest child of President John F. Kennedy and First Lady Jacqueline Bouvier Kennedy, was born prematurely and then died of lung disease 2 days later at Children's Hospital in Boston. Even now, it is common…
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Correspondence
Oxygen-Saturation Targets in Extremely Preterm Infants
To the Editor: Questions have been raised about the consent process for the Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT). The SUPPORT study was designed, in part, to test the hypothesis that a lower target range of oxygen saturation (85 to 89%), as compared with a…
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Perspective
Risk, Consent, and SUPPORT
Comparative effectiveness research has the potential to dramatically improve patient care while reducing costs. In the absence of good evidence about which treatment is best for particular patients, decision making too often hinges on exogenous factors such as advertising and detailing by…
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Perspective
Discrimination at the Doctor's Office
Doctors dedicate themselves to helping others. But how selective can they be in deciding whom to help? Recent years have seen some highly publicized examples of doctors who reject patients not because of time constraints or limited expertise but on far more questionable grounds, including the…
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Perspective
From Illness as Culture to Caregiving as Moral Experience
In the early 2000s, my wife developed early-onset Alzheimer's disease, and I got taken up in the everyday reality of being her primary caregiver. The experience was transformative on a professional as well as a personal level: although it validated my decades-long insistence on the primacy of…
Perspective
The Ethics of Not Hiring Smokers
Finding employment is becoming increasingly difficult for smokers. Twenty-nine U.S. states have passed legislation prohibiting employers from refusing to hire job candidates because they smoke, but 21 states have no such restrictions. Many health care organizations, such as the Cleveland Clinic and…
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Perspective
Conflicts and Compromises in Not Hiring Smokers
Tobacco use is responsible for approximately 440,000 deaths in the United States each year — about one death out of every five. This number is more than the annual number of deaths caused by HIV infection, illegal drug use, alcohol use, motor vehicle injuries, suicides, and murders combined and…
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Sounding Board

Made-to-Order Embryos for Sale — A Brave New World?
Embryo donation (also known as embryo adoption) is the compassionate gifting of residual cryopreserved embryos by consenting parents to infertile recipients. At present, only a limited number of such transactions occur. In 2010, the last year for which U.S. data were available, fewer than 1000…
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Perspective
Safeguarding Children — Pediatric Research on Medical Countermeasures
In 2011, a bioterrorism-preparedness exercise conducted by the U.S. government examined the likely result of a large-scale release of weaponized anthrax spores in a city such as San Francisco. Code-named Dark Zephyr, the simulation was sobering: nearly 8 million people would be affected, nearly a…
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The Presidential Commission for the Study of Bioethical Issues has concluded that before pediatric trials of anthrax vaccine can be considered in the absence of an outbreak or attack, further steps must be taken, including additional research in adults, to reduce risks to participating children.
Perspective
Ethical Physician Incentives — From Carrots and Sticks to Shared Purpose
As health care reform's focus turns to change in U.S. health care delivery, concerns about the use of incentives for physicians are intensifying. One fear is that incentives will undermine physicians' professional ethos, leading them astray from the primacy of their duty to patients. Another fear…
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Clinical Decisions
Medicinal Use of Marijuana
Case Vignette. Marilyn is a 68-year-old woman with breast cancer metastatic to the lungs and the thoracic and lumbar spine. She is currently undergoing chemotherapy with doxorubicin. She reports having very low energy, minimal appetite, and substantial pain in her thoracic and lumbar spine. For…
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Perspective
Speaking Up — When Doctors Navigate Medical Hierarchy
He's the first patient of the day: admitted overnight, he's scheduled for surgery this morning. "Do you want to catch him before or after?" the resident asks. "Is there anything we need to do for him right away?" I say. When she says that the night resident mentioned some pain issues, I decide to…
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Medicine and Society
How Much Would You Give to Save a Dying Bird? Patient Advocacy and Biomedical Research
In 1994, Frank McCormack, a pulmonologist interested in innate immunity, arrived at his new job at the University of Cincinnati to find a letter on his desk. It was from Sue Byrnes, a music teacher whose 22-year-old daughter Andrea had been diagnosed with lymphangioleiomyomatosis (LAM), a slowly…
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Perspective
Recognizing Conscience in Abortion Provision
The exercise of conscience in health care is generally considered synonymous with refusal to participate in contested medical services, especially abortion. This depiction neglects the fact that the provision of abortion care is also conscience-based. The persistent failure to recognize abortion…
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Health Law, Ethics, and Human Rights
Ethical Considerations in Studying Drug Safety — The Institute of Medicine Report
The tumult arising from revelations of serious safety risks associated with widely prescribed drugs, including rosiglitazone (Avandia, GlaxoSmithKline), rofecoxib (Vioxx, Merck), and celecoxib (Celebrex, Pfizer), has led to widespread recognition that improvement is needed in our national system of…
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